Longevity, Senescence, Autophagy, mTOR Inhibition + More w/ Jeff Grimm 55,640 views Mar 25, 2020

BIOLOUNGE Longevity, Senescence, Autophagy, mTOR Inhibition + More w/ Jeff Grimm 55,640 viewsMar 25, 2020 High Intensity Health 543K subscribers Jeff discusses science-based ways to get rid of these senescent (old) cells—which may help both longevity and immunity. ➢ This episode is sponsored by Redmond Real Salt! Salt hand-harvested and microplastic free. Get the best salt in the world: https://bit.ly/real-salt ➢Connect with Jeff: https://bioloungepdx.com ➢Episode Show Notes & Research: https://bit.ly/senolytic-therapies-1 ➢Related Episode about Telomeres w/ Jeff: https://youtu.be/L3irS84U8rs --------------Sleep & Camera Tools You NEED!----------------------- Best Sleep Mask: http://bit.ly/2AIVbDV Blue Blocking Glasses: http://bit.ly/blueblox Gravity Blanket (use code HIH10 to save): http://bit.ly/cooling-gravity-blanket A Metabolism Book Should Have:https://amzn.to/2jUiAh5 Best Mouth Tape (Nexcare): https://amzn.to/31qJayh Red Headlamp (wear this at night around your house): https://amzn.to/2YzMGtw Breath Right Strips: https://amzn.to/31t5VSl Best iPhone Stabilizer: https://amzn.to/2IuCFFw Sony Vlog Cam: https://amzn.to/2DhRV4j My Interview Camera C100 ii: https://amzn.to/2EC5NE8 Vlog lens: Canon EF-S 17-55mm f/2.8 IS: https://amzn.to/2IGlfSo Good Audio: Rode VMPRPLUS Videomic Pro: https://amzn.to/2v9W9cm -----------------------------------------Show Notes-------------------------------------- 05:07 Sauna research indicates that when your heartrate is about 140, you are in the right temperature for cardiovascular benefit and releasing heat shock proteins. 08:19 With age comes senescent cell accumulation; cells that do not perform their essential functions, do not self-destruct and effect surrounding cells. 09:06 If you can get rid of senescent cells in your body, you get a 10 or 20% life extension. 10:50 A senescent cell intervention study caused most senescent cells to go away. 15:30 Autophagy has a senolytic effect. 16:32 If there is low autophagy activation in the body, lifespan is shorter. 19:10 DNA expresses itself differently when autophagy is upregulated. 20:30 Stem cell activation increases in the refeeding stage after a fasted state. 22:15 In mice, it takes at least a 2-day water fast to induce autophagy. 26:30 If there are a lot of nutrients in the environment, cells grow and procreate. In cancer, this is not a good thing. 27:10 If there are no nutrients in the environment, cells get good at recycling/scavenging and hunkers down to protect its DNA so it cannot break. 28:44 The antioxidant theory of ageing has been debunked. 30:33 A constant feeding state stimulates cancer growth through upregulation of growth hormone IGF1 and insulin. 33:36 Testing can show where patients are on the longevity path. 36:24 Overconsuming protein by over 20 to 30% in your diet, you get increased IGF-1. 37:39 A good IGF-1 level, based on Blue Zone cultures, is around 150 for mid-life. 42:14 If you restrict methionine in mice, they live longer. 46:05 AMPK can be activated through Metformin, berberine or the Chinese herb jiaogulan. 48:02 Rapamycin works well to suppress TOR in animal models. 51:22 NAD is the rocket fuel needed for sirtuins to do their job to protect DNA. Fasting increases NAD. 56:17 We don’t know if taking NAD increases lifespan or if it lowers cardio-metabolic risk. 01:00:35 Your DNA gets methylated as you age. When DNA is methylated, certain sections of DNA code are turned off and your cell does not do what it is supposed to do. 01:02:50 CPG sections of DNA are highly correlated with the ageing process, if they are methylated. It is a better marker for ageing than telomeres. 01:03:59 When your DNA at the CPG sites is methylated, it is irrevocable. 01:04:40 Ageing tests, from Elysium and myDNAge examine CPG sites. 01:08:35 The DNA clock was reversed by 2 ½ years. 01:13:07 Paradoxically, studies show that increases in growth hormone leads to longevity benefits, yet high growth hormone is disaster from a longevity standpoint. 01:17:40 DHEA for men is probably safe with a recommended dosage of 25 to 50 ml. DHEA has a positive effect upon the immune system and helps with certain markers of cardiovascular function in men. 01:21:37 Low levels of DHEA increase your risk of all cause mortality. 01:23:12 Fasting mimicking, to a higher extent than fasting, increases mucosal stem cell activity. 203 Comments rongmaw lin Add a comment... Luann Rouff Luann Rouff 2 years ago If a drug is strong enough to help you, it's strong enough to hurt you. I just want to be healthy now. For me that means no sugar, no alcohol, no dairy, no wheat, plus intermittent fasting. Also, eat with pleasure and a grateful heart. Spend time in nature. Hope 2020 is a year of "good vision" for the planet and all its inhabitants after recent events. 99 Roustabout4fun Roustabout4fun 2 years ago (edited) This is going to be good! Complicated but his articulation for us is a gift ..... Wonderful channel that gives us the gift of motivation to clean up our maintenance. Nice ! 41 Elizabeth Booth Elizabeth Booth 2 years ago Jeff, many of us are so thankful for Mike. Most doctors treat chronic fatigue, etc as non diseases. One becomes exhausted asking for help. Best regards, Elizabeth 7 Davina Davina 2 years ago This channel is pure gold! Thank you for sharing this very interesting discussion. 8 Mindhive Mindhive 2 years ago Does anyone else feel this primal surge of energy and intuition when they go on a long fast? For me it's always felt like I'm reconnecting with my ancestral roots. 4 Bernadette Becher Bernadette Becher 2 years ago Such a great conversation and so much information here. Thank you for passing on this knowledge in the podcast. 3 V4D2 V4D2 2 years ago the last video you did with Jeff is actually one of my favorites of yours, so i had high expectations for this one. i’m glad to say that it didn’t disappoint ;) . So kudos to you both. Many thanks! i’m currently 115lbs (177cm tall) and i want to return to my previous 150..160lbs. It is pretty hard to gain muscle mass doing intermittent fasting, in deed, so i am considering going from 3 meals, to 4 . that would mean i would have to forgo the 12hour no-food window.. Judging from what you guys talked about, scientific data/confirmation on the benefits of that 12hour window are still pretty scarce.. I didn’t know that. i thought it had been scientifically shown that it really has benefits. A 2 to 3 days fasting once a month might be a good idea, then, i feel. Still..i’m currently 4.5% fat..so fasting is very tasking on my muscle tissues.. what do you reckon ? thanks again Mike, cheers from Portugal 10 High Intensity Health Gonzalo Corts Gonzalo Corts 2 years ago You always have such interesting interviews Mike!!! Thanks for putting out these videos!!!!! 🙏🏽 3 party38 party38 2 years ago Thank you for another great informative episode! Recently watched Dr. Mercola where he said that we should be cautious with fasting due to toxins that are being released from fat storage where they accumulate into blood stream. What are your thoughts on this? Thank you 4 gatobava gatobava 2 years ago Wow! Great talk and great guest. Covered a lot of topics and explained well for the lay person. 8 High Intensity Health Lili Robin Lili Robin 2 years ago (edited) I learn so much from your channel. You are the best at the interviews!!!! You are so smart but let the others talk. Just excellent! 2 Pepper Pepper 2 years ago Awesome show! Notes taken throughout. Thank you for the knowledge! Bill kimura Bill kimura 6 months ago Great interview Mike. Keep doing what you do. 👍 OliverMarcellBjerregaard OliverMarcellBjerregaard 2 years ago Awesome info as always! And Mike, my man, looks like you've been putting on some solid muscle mass! marygraceful marygraceful 2 years ago These guys are brilliant wow. Thank you for sharing such rich knowledge 2 FEVERED DREAMS FEVERED DREAMS 2 years ago Such a revelation, thank you so much for your dedication! uelude uelude 2 years ago (edited) Amazing video, Jeff is a wonderful and intelligent guy. I'd really like to see Ted Naiman's response to Jeff regarding protein, would love to see that chat. Also importantly I'm very curious to know how Jeff, as a thinner guy, approaches the subject of gaining muscle or simply working out, or perhaps he prefers not to thereby having a younger body and mind for longer? It's really ultra key for keto dieters who are losing muscle mass. There are many recommendations of 2g of protein per kg per day.. but how to fit that in a 4 hour feeding window? The body would have trouble processing 150g+ of protein so muscle gain is extremely difficult. And using a long window we hear time and again over-stimulates mTOR Do you know of anyone willing to put forward a strategy to balance Protein, mTOR, and muscle growth (or at least prevent muscle wasting) while not overstimulating mTOR / IGF1 which we hear all the time is the big bad move in the longevity game. For example: Goals-wise I'm keto for inflammation reduction (it works) and fast for autophagy and I feel great afterwards which leads me to conclude it's also anti-inflammatory. But I've lost my 10kg of fat and I'm losing muscle.. following Naiman's philosophy I should just eat tons of protein.. which is exactly what I had planned until this vid which yet again drove home hard the IGF1 message extremely eloquently. If feeding window (or the 20 hour fast out of it) is the solution then is there a way to consume 150g in 4 hours without the body just saying "too much protein to process properly let's convert some into glucose and dump a load". I was thinking 3 day fast (starting keto adapted it's quite intense) at the end of each month to help cleanse the mTOR mess from too much protein during the month. Maybe a 2 day fast mid month also. Possibly choose a 'big work out' day once a week where I forgo the feed window rule. Seems quite a 'pulsatile' compromise.. although the 150g a day in a small feed window is the biggest question.. is this wise? Logistically seems possible but idk how the body would process it (apparently body can process 60g after workout.. maybe start: Take 30g protein with keto lunch, then 2h30 later 15g EAA then work out and 60g whey isolate immediately after, then 45g (eg: 150g meat) in a meal after an hour, close window. ) Is this wise or am I messing with IGF-1 and mTOR too much? Trouble is in a nutshell: I'm 37 and getting old.. keto is perfect to reduce inflammation but I'm losing muscle mass, a solution is high protein a la Naiman but INF-1 and mTOR are so important especially hearing Jeff reiterate and further embue some very wise mTOR lore. Final idea for discussion: Feed window on alternate days (eg: 4hr window except 3 training days a week where there is 8hr window where you could have 150g protein starting 30g in the morning workout after 2 hrs then 60g, then 2 hrs 30g 2hrs 30g.. Then next day, the alternate, back to 4 hr window with lower protein (BUT HOW MUCH can you take on a rest day in 4 hours on keto?) We don't hear so much about a 2 day oscillation detailed in interviews, occasionally though. This stuff is not for bodybuilding per se, it's so fasters and keto community can stay healthy and avoid muscle loss.. it happens! Any thoughts? Or links greatly appreciated. :) 4 Brynn Major Brynn Major 2 years ago Wow thank you for this!! Also, the detail in the description box🙌🏽 9 High Intensity Health Sarah Sandoval Sarah Sandoval 2 years ago SO GOOD- gonna watch it a third time- lots of great info to absorb! 👍🔥👍 omnipenguinify omnipenguinify 2 years ago (edited) Could you talk about criticisms of the blue zone study? The main one being that it cherry picks these zones. There are other long lived populations that don't eat 10% protein. Hong Kong being an example here. And the other criticism was that some of the zones weren't really plant-based. Okinawa being the most egregious example. Another thing, Americans don't eat 30% protein. We eat 10-16% protein. 6 Ricardo Wilkins Ricardo Wilkins 2 years ago One of the most effective ways to restore or eliminate senescent cells is by replenishing our bodies with stabilized ROS/RNS. They have several roles in the body, one being cellular messengers and our bodies built-in method to detect repair or replace damaged cells. Um Nachtet Um Nachtet 2 years ago The longevity vs performance discussion is essential Jay Gonzalez Jay Gonzalez 2 years ago Luv the intro man. I appreciate your work. Thank you for your time. 🙂 8 High Intensity Health Aiyang Tao Aiyang Tao 2 years ago Great talk ,thanks . Could you please discuss C 60? It seems better than Vitamin C. Emery Cole Emery Cole 6 months ago Kirkland has some good insight concerning sentient cell recycling. I’m ketogenic & mostly Carnivor, OMD, 48h/wk Fast & KAATSU-BFR newbie. Great health results but way to many “IF’s” about pills-supplements etc. I take NAC, D3 a few times a wk but feel best just by eating lots of Real Salt! N=1 keep searching. Glen Meyer Glen Meyer 2 years ago One of the best videos you have released...! 35 High Intensity Health Azaliia Persits Azaliia Persits 2 years ago I loved it so much! Thank you ! 1 Sid Michael Sid Michael 1 year ago (edited) Life changing lessons right here. Raw Bacon Raw Bacon 2 years ago Hour and a Half, looks like I got something to keep me company while I do a little woodworking today. 3 Eviya Eviya 2 years ago I dont need a cake. This video is the 5-Michelin-star treat! 12 Boon Doggle Boon Doggle 2 years ago When they say that a certain percentage of your diet should be made up of protein, are they presuming that you’re eating three meals a day in a standard eating pattern? What if you only eat one meal that day? Is it really a matter of the percentage or the amount, and if it’s the amount, what amount would they say is ideal? 4 Angela A Stanton PhD Angela A Stanton PhD 2 years ago Awesome! truly enjoyed this chat. 1 El Jake El Jake 3 months ago I think the focus on mtor and igf-1 is from a place of not looking at the body as a system. I enjoyed this guy’s perspective and I appreciate that he stressed that they are still important. Valter Longo annoys me greatly. Fasting is obviously superior to fmd and he focusing on processes that are simply not being utilized by the body correctly. You shouldn’t want to down regulate mtor or reduce igf-1, the goal should be to direct it to metabolically active tissue! Get in a lift in the am or anytime before breaking a fast and you will do just that! Same with metformin, it’s just doing exactly what your body does after exercise. To me it’s simple, lift before eating and walk after. Personally the lifting part is easy, the walking I neglect, but I think the lifting is more important in the context of growth factor sequestration. Enjoyed the discussion as always! Thank you, Mike! 1 Steven Noren Steven Noren 2 years ago A place I want to go at 63 years old trying to reverse age and improve health I've managed to reverse quite a bit but a lifetime commitment is what it takes. 4 Jean Carlo Him Jean Carlo Him 2 years ago How can you measure the levels of disfunctional cells? TALENA AN TALENA AN 2 years ago I haven't seen you do any talks on Ozone. Ozone has helped me so much! I have tried every "healthy" thing from A-Z and nothing has helped me more than ozone. I would love for you to do an interview or talk about it. 1 Ida Ida 2 years ago Jeff says the word fruit and Mike has to say fish. Mike, what’s wrong with your brain? Fruit is good. Sandro Itsme Sandro Itsme 2 years ago Regarding vitamin C, it looks like you guys are ignoring the fact that a primate the size of a human would make 10 grams of vitamin C and we make none. I'm 71 and haven't had a cold or the flu for over 40 years. All that time I've taken at least 6 grams daily, but often much more. Also, no one ever guesses me to be over 50, so I'm not about to shun C! 20 Chad Aitken Chad Aitken 2 years ago Good stuff Jeff, thx Mike. Renewed interest with DNa and DHEA. Jeff made it sound like DNa methylation is permanent? Is it like breaking a segment of an erector set? How does smoking do that? We can’t repair it? Thx. Purple Gh0st Purple Gh0st 2 years ago Mike, What are the benefits of taking metformin if you are not prescribed it by a medical doctor? 2 Final Start Fitness Final Start Fitness 2 years ago (edited) I remember the Telemere talk.. that one was so good!! 2 Robert Flury Robert Flury 10 months ago I couldn't quite make out the two drugs they use in the anti senescence trials he mentioned around 10:50 . One was an anti chemo drug and the other sounded like a supplement. Josh K Josh K 6 months ago This one didn't get enough views. Great interview Jody Jackson Jody Jackson 2 years ago So. NIce to see two people sitting together closer than 6 feet apart talking 🤗 4 Keith Haken Keith Haken 6 months ago Very good material. Except for that billion year old single cell (apparently with its own brain) floating in the ocean and evolving into people. 🤣 John Hughes John Hughes 2 years ago This is fantastic. How can you test your DHEA? Truly Truly 2 years ago What does this mean for Carnivore Eaters? I've always been fascinated and perplexed about the implications of Carnivore Eating as it relates to Longevity and mTOR activation. 4 john bassett john bassett 2 years ago Why is it always about taking a supplement unless you have decreased availability through poor absorption as you age? 1 Green Deane Green Deane 2 years ago If avoiding cold baths means I will die young then I will die young. I loathe being cold. Conversely I love long, hot saunas. 5 Thomas Jepsen Thomas Jepsen 2 years ago Amazing video! 1 Stephen Hazel Stephen Hazel 2 years ago ok Mike - are YOU gonna try that? 3 days of 1000mg Quercetin + 100mg Dasatinib? If that kills off a lotta lame cells, that sounds pretty cool! I guess I'd need a prescription for Dasatinib. I watched this a 2nd time. startin 50mg DHEA each morning with my bp med cuz i'm 54 and it can only help i think. ordered myDNAge :) Did my longest fast about a month ago - 3.5 days. Gonna try it quarterly with that FMD stuff. Stephen Hazel Stephen Hazel 2 years ago thankk you! best video everrr. I learned a lot. will watch a second time tomorrow. Sid Michael Sid Michael 1 year ago Can fasting kill senescence cells? 1 A.D. ROSS A.D. ROSS 2 years ago I LOVE REAL Salt! I get their Seasoned Salt also. The Only Jamie Bourgeois The Only Jamie Bourgeois 2 years ago Watching this while on the third day of a water fast. 3 Jay Leon Jay Leon 2 years ago Does d ribose boost nad naturally? Any studies on specifically? I've searched online but thus far I haven't found one. Actual Nad seems to be very expensive. Brian Richard Brian Richard 10 months ago I intend to live forever. So far so good. - Steven Wright 2 Marcus Glading Marcus Glading 2 years ago mike are you worried about taking dhea and the link to bad outcomes for steroid use with covid patients william zebrowski william zebrowski 2 years ago with regard to animal protein, IGF-1 and people in hong kong eat a pound and a half of meat a day , i think Dr Saladino would disagree with you strongly with all due respect , interesting info anyway 1 Madina Vadache Madina Vadache 2 years ago (edited) We just scratching the surface of untagging science.its the next level when you are general health is good👍🏻👍🏻 7 High Intensity Health gaurd3 gaurd3 2 years ago (edited) I paused Tiger King for this. There is so much foolishness you can watch before it rubs off. lol Great talk Diana Valdez Diana Valdez 2 years ago Love this 👍👍👍 John Osborne John Osborne 2 years ago Got super nerdy!!!! LOVE IT!!!!!!!! guitargeeknwa guitargeeknwa 1 year ago He mentions blue zones consuming only 10% protein, but these 'blue zones' have been debunked, not only by researchers but by people who live or have lived in these areas. How long do you think you are gonna live, anyway? If you only eat 10% of calories as protein, you're likely gonna be weak in old age. I don't think 10% protein facilitates 'strongevity'. Otherwise, a wonderful interview and discussion. Naima B Naima B 2 years ago Quercetin is zinc ionophore, which help immune system what do you think about these 2 combinations? 1 GMW GMW 1 year ago I was in Portland 12 years ago. Liked it a lot. Too bad it's been all downhill since this interview was done. Downtown Portland is a no go zone now isn't it? Hank Nelson Hank Nelson 2 years ago Maybe Autophagy is not a sprint, but a marathon. Slowdown and go faster. Rebounding From Narcissistic Abuse Rebounding From Narcissistic Abuse 2 years ago Only watched 1 min and I am hooked 2 Kid Vinie Kid Vinie 2 years ago He is one interesting guy! Rambling Rose Rambling Rose 2 years ago (edited) Great interviewer! Fascinating Guest! Wonderful topic! Stop Eating, People! It's that simple!!!! 2 Teresa Moews Teresa Moews 2 years ago I'm looking for anti cancer in all this longevity data. I'm a two time cancer patient in remission and want to stay there. I eat mostly whole foods and plant based. I just learned about NAD+ and how it grows cancer... Can you give me some direction? Sophal27 Sophal27 2 years ago (edited) NAD, GH, DHEA, testosterone, metformine, why suplements when you can have similar or even better results just by eating well, intermittent fasting and weight lifting, and for much cheaper. 5 Pink Supremacy Pink Supremacy 2 years ago I had super low levels of DHEA and I recognize all of the symptoms of no energy etc. But I cant get a hold of it in fucking socialist Sweden. Do you know where I can get it??? I'm 32 btw. Naima B Naima B 2 years ago Hi Mike Love your channel Suer Erin is zinc ionophore is 1 g per d sufficient Alex Berukoff Alex Berukoff 1 year ago (edited) AWESOME VIDEO,, HAVE YOU ANY THOUGHTS ON FISETIN 1 Sid Michael Sid Michael 1 year ago What is DHEA for? Indigo Love Indigo Love 2 years ago Thanks so much. Great information, but he spoke way too fast. Blessings 1 SuperResistant SuperResistant 2 years ago Excellent Para Bellum Para Bellum 2 years ago When you want to wear a blazer but they turned up the heat ;) 5 Van Lee Van Lee 2 years ago Does any one have a link for the topical rapamycin? Susan Beever Susan Beever 5 months ago No mention of oxytocin and stopping senescence. Marky Mark Marky Mark 2 years ago 4 to 5 days for autophagy 👀👀 yikes, please make him stop. . . Lol. . . I'm running with the idea that as I am physically active allows me to activate it much quicker 1 Gold Hunter Gold Hunter 11 months ago Let's see...............with carbon 60, AKG, rapamycin, eeg and spirmidine then maybe I can still have my chocolate milkshakes. emmas816 emmas816 2 years ago 1:35 -Redmon Real Salt contains crashed glass, every bite of food salted with this salt makes this horrible sound on my teeth like I am eating sand. Not going buy it ever again. 2 tbmcnation tbmcnation 9 months ago salt consumption shortens telomeres M M 7 months ago You guys are "Truth Seekers." Sid Michael Sid Michael 1 year ago 51:10 is the final answer. Teb Tengri Teb Tengri 2 years ago So what was the chemotherapy drug he hinted at around