The Role of Mitochondria

The Role of Mitochondria in Aging and Disease - David Sinclair 221,983 viewsMar 6, 2014 Serious Science 88.3K subscribers Source - http://serious-science.org/videos/738 Harvard Prof. David Sinclair on alphaproteobacteria, reactive oxygen species, and why the nucleus and the mitochondrial genomes are like a married couple 458 Comments rongmaw lin Add a comment... hamed shahbazi hamed shahbazi 6 years ago Amazing work Dr. Sinclair! So impressed with not only your work but your ability to explain it!! 19 Carroll Hoagland Carroll Hoagland 5 years ago (edited) Thanks Dr. Sinclair .. a fan ... will be watching the outcome of your research ... since I am specializing in mitochondrial dysfunction pertaining to aging from a dietary approach, since as you know we have longevity mechanisms that repair all damage ... we just have to get out of there way and support our own metabolic processes as these bodily mechanisms are far more powerful than any supplement you can take ..., 70 Going On 100 … the Centenarian Diet … maybe 70 Going On 128 … the Hayflick Limit, or if a fan of Ray Kurzweil … then this is all a Moot Point. 17 Biophilia Biophilia 10 months ago (edited) Sir I have read Your book "Lifespan" on the same topic of aging - It was too informative ..I am Your big fan 😇..Loads of love from India. 6 ido shapira ido shapira 3 years ago Great lecture, sounds like the progression of insulin resistance. Thank you 7 Benjamin Hardisty Benjamin Hardisty 7 years ago I'm actually an aging researcher myself. Trust me, the Sinclair lab is top notch. SENS is funding great work, but they're not bringing anything to market in the next 10-20 years is my guess. I don't even think the NAD treatments or protein chaperone treatments Sinclair's lab is studying will get anywhere for years either. Consider that mTOR suppressors can both raise and lower lifespan and we don't fully understand why and we've been using them for decades to get an idea of the technical challenges. My mTOR model is a 26 ODE system. My lab mates said, "Oh that's why no one's made a good mTOR dynamics model." 21 William Tomkiel William Tomkiel 2 years ago so glad I found this . . Been on NAD, 100 mg. /day for almost 2 1/2 years along with Co-Q10, Carnitine and Creatine as also being mitochondrial supporters and at 72 function and perform as a man many years younger but it's also about sleep , stress, recovery protocols for the gym work-outs and so forth. 7 Ben Nguyen Ben Nguyen 3 years ago (edited) What determines the actual number of mitochondria per cell? Is it tissue dependent or based dynamically on energy needs? Bruce Hay on the HumanOS podcast, mentions with respect to mitochondrial genomes, you have hundreds to thousands of them: "In every cell we have hundreds to thousands of these organelles floating in the cytoplasm. They’re always being generated, and they have their own genomes. It’s not just one genome for all mitochondria, but thousands." Does he mean that each mitochondria only has a portion of the mtDna? Isn't the mtdna so small (37 genes) that it barely codes for proteins anyways (13)? He goes on to say, that the "nuclear DNA is well positioned for repair, because we have two copies of all of our chromosomes. What that means is, that if the copy you inherited from your father is damaged in some way, the copy you have from your mother can actually act as a template for repair. In that way, through homology based repair, you can oftentimes reconstruct the information that was lost in the damaged strand." There was a good 'Ask Me Anything - with Spencer Wells and Razib Khan', but didn't cover basic questions like this. 2 Halima Zamouche Halima Zamouche 2 years ago All your work is amazing! Wish you all the best! You only need to get this you can live healthier and maximise your body's performances but you will certainly die! Thats sad but it's a fact that we can't deny! Everybody dies and it's for a reson if people that lived before us didn't die we would be looking for another planet to live in! Even cells in our bodies die when other new ones appear! God bless you! 1 Winston Chang Winston Chang 2 years ago Very insightful, Doctor Sinclair. I can clearly see the worth of you living a longer life because you are an important part of human society with your intelligence and knowledge. You are our mitochondria. But , what do I do with a longer life or that of billions of people. ? .....?....Like , I do not want mice to live longer lives..... 6 Glenn Decker Glenn Decker 6 years ago Great ideas, but more basic science questions should be asked at the level of cell biology and ultrastructure. 4 Raven’s Lair Raven’s Lair 3 years ago Excellent. A very well spoken Professor. I have so many questions! Would taking NADH assist in this regeneration?? 4 Hobby Farmer Hobby Farmer 3 months ago Dr. Sinclair looks younger now (2022) than he did in 2014. That means his approach worked, i.e. diet, intermittent fasting, supplements, etc. 2 ZeraYaqob ZeraYaqob 2 years ago The human microbiome directs the communication between the cells and mitochondria as well as between other cells. One example is the role of menaquinone or vitamin K2, synthesized from vitamin K1 or phytonadione by certain bacteria in our gut, as a participant of the oxidative phosphorylation or electron transport chain (where 94% of cellular energy is produced) through its ability to accept and transfer electrons. 16 saxmanchiro saxmanchiro 7 years ago It's a hypothesis, not a theory, yet. This reminds me of Dr. Dean Ornish's idea, back in the mid 80s, of reversing heart disease with diet only, quickly. Many in the medical field scoffed at him and chastised him for his foolishness. Now we know the truth. He was right. Sometimes, a crazy idea in science gets ridiculed until the irrefutable evidence comes in. Could be a game changer for sure. 53 Alex Alex 2 years ago (edited) Wouldn't it be possible to look at the mitochondrial bacteria types which are living outside of human bodies, where they are less protected, to find some gens which could be used to make our Mitochondria more resilient to damage and mutations? 4 Tomas Hull Tomas Hull 1 year ago Aging can't be stopped... Everybody dies... Some signs of aging could be slowed down and reversed... temporarily... The cell division processes breaks down eventually... the telomeres get shorter each time it happens... mutation load in increases with age... It's all driven by quantum mechanics... 3 Vicente Sanchez Vicente Sanchez 2 years ago Excellent lesson and info. Thx 1 Serious Science Baljit Singh Baljit Singh 10 months ago Very informative information 👍🙏 2 Neville J Neville J 3 years ago I am nearly 65 and have found that taking a small amount of D-Ribose and some Creatine daily has given me a massive amount of energy and strength so much so that two or three days a week, I will run a 5K followed by an hour in the gym doing a heavy workout and then do about 3/4 hour of swimming and still feel like I could do more. I suspect am as fit as I was in my twenties. 14 Pritam Borah Pritam Borah 7 years ago your analogy of the broken marriage of genomes was the best part.... 62 Nick Foxer Nick Foxer 2 years ago (edited) Great video, but he failed to mention the most important molecule responsible for mitochondrial function. OXYGEN..... Two words: Ozone Therapy. Learn as much as you can about it. In my opinion it's the single greatest practice we have for restoring health. I actually think the "secret molecule" that he's hinting at toward the end of the video (10:40) is Ozone. 4 Chris McAulay Chris McAulay 7 years ago Incredible - now I just need to find a reason to live - lol 252 thexeesus thexeesus 2 years ago Hm, his current 2019 theory describes aging in terms of epigenetic decline which seems quite different compared to mitochondria-nucleus interaction. Although in both cases decline in NAD plays role. Just questioning how reliable is all these. 4 EK Lim EK Lim 3 years ago (edited) "Dear GP, how to make my heart age slower?" GP: "you should ask a cardiologist" "Dear cardiologist, how to make my intestine age slower?" Cardiologist: "you should ask a gastrologist" "Dear gastrologist, how to make my whole body age slower?" Gastrologist: "you should ask a GP" 16 IW Nunn IW Nunn 2 years ago I don't want to live forever. I just want to be healthy and live an optimum life while I'm in this body. 61 Kevin Fairweather Kevin Fairweather 3 years ago Very succinct explanation ! 1 Command Results Command Results 7 years ago Great talk theorizing the future of mitochondrial development as related to aging and longevity, 2 Mark Sze Chai Chan Mark Sze Chai Chan 6 years ago Thanks it is fascinating! 7 Srtj.Av. Srtj.Av. 2 months ago I love when he smiles as is a good thing happening! 😊 pikiwiki pikiwiki 2 years ago I understood everything! 5 Graeme Gladman Graeme Gladman 1 month ago You need to research vit K2 or and L - Citruline for its anti aging effects. It has wiped my wrinkles and made me years younger. I don't know which one is responsible or it could be a combination of the both. spruceguitar spruceguitar 1 year ago "I do not want to live forever in the memory of the people. I want to live forever in my apartment." Woody Allan 7 GrooveDoctor77 GrooveDoctor77 7 years ago I have tried Niagen about a week ago , Im still sceptical but, I have(had ) 3 loose teeth , but just yesterday I noticed 2 of those teeth have tightened by a large degree , the 3rd tooth is still loose but even that tooth has tightened ..so after week I have hopes that this product is working,(re edit (3/2015) after 2 months of Niagen...I am completely amazed at how well this works, I could list 7 or 8 improvements all over my body ...the most recent amazing thing is..I have been diagnosed diabetic for 5 years, I still eat the same ,.. but I have had to reduce my med intake (I probably will quit Glyburide soon) because my glucose levels were dropping to normal by themselves , I lost 8 lbs of fluid retention after the 2nd week... I am 165 lbs from 173, never realized the bloating in my face & body until I looked at a video from Nov 2014 & compared it to a video I made a couple of weeks ago..1 thing I can say...thanks Dr, Sinclair 12 Blue Jay Blue Jay 2 years ago (edited) what's calcitrol? i saw it in the the Closed Captioning. Mitochondrial Autophagy is caused by Parkin-pink1. Parkin-Pink1 attaches to a receptor on the outter mitochondria membrane. there's 2 types of autophagy. Selective Autophagy from pomegranate's elligic acid and a specific probiotic trigger selective autophagy and universal autophagy from Intermintent fasting. Autophagy is when a damaged mitochondria gets enveloped by a membrane with a libosome. And breaks the mitochondrion into amino acids. to be recycled back into the cell. selective autophagy is the type triggered by high ROS from damaged mitochondria.universal autphagy just autphagies them all, except the Mitochondria. beacause the mutant mitochondria don't.produce ATP. So no ROS by product. to help facilitate the bond of Parkin-Pink1 to the autophagy receptor on the outter membrane. i know South Korea has developed a healthy mitochondria injection method. and England has their mitochondrial donor program for three parent babies. Is there a connection between mitochondrial fuction and telomere? i wonder. 1 C B C B 2 months ago Where did alpha proteobacteria (precursor to mitochondria) come from, and how did they become part of us? How did humans create energy before this happened? Hainet Korea Corporation Hainet Korea Corporation 1 year ago Marine algae.Green seaweed(Chlorophyta) Ulva prolifera is a species of seaweed in the family Ulvaceae that can be found worldwide. Ulva lactuca(linza, pertusa, rigida) etc The pigment comparison of photosynthetic plants and green seaweed. The nine pigments based on chlorophyll in green seaweed are the same as plants. What is the structural color of green seaweed ? It is the color that appeared in the natural physiological and ecological environment when photosynthesis in the earth's environment. Nine Colors:Green,Yellow,White,Pink,Red,red-Purple,(reddish Brown-Brown),Blue,Black. The changes in the color of green seaweed are intended to communication with each other due to environmental conditions.(transformation of chromaticity and breeding of offspring) Who are the ancestor of life on earth ? Genetic and evolution of Earth life.(Eukaryotes: Mitochondria) Mitochondria are Alive:Dried, Bleached, Melted, Rotted(Black) mt DNA: Genetically, it has pigments information and Produces photosynthetic pigments. mt DNA: Nine genetic pigments(Rainbow colors and white, black) Nine melanin pigments(Skin, Eyes, Hair):Human, Marine and Land animals joe schmo joe schmo 5 years ago The body likes to have a 700:1 ratio of NAD to NADH according to a video by Shallenberger. That shows how important NAD is. 2 Kay Halsey Kay Halsey 3 years ago Thank you for the information. 2 Sun Sun 3 years ago sleep, nutrition, movement, absence of stress, good emotions +++ 39 Secret Soul Secret Soul 1 year ago (edited) We dont need to live forever, if we do, we are having lot of problems in coming. Plus we are not dying just bcoz of aging... Pandemic, accidents n killed... We not study aging to live forever Prof, but why aging science is important, its because aging related to many diseases. With our modern unhealthy living styles, we only look for remedies of the damages we have done. Study ageing is my favorite stuff but to live forever... Thats on diff page😂 Nick Foxer Nick Foxer 2 years ago (edited) Great video, but he failed to mention the most important molecule responsible for mitochondrial function. OXYGEN..... Two words: Ozone Therapy. Learn as much as you can about it. In my opinion it's the single greatest practice we have for restoring health. I actually think the "secret molecule" that he's hinting at toward the end of the video (10:40) is Ozone. 4 Chris McAulay Chris McAulay 7 years ago Incredible - now I just need to find a reason to live - lol 252 thexeesus thexeesus 2 years ago Hm, his current 2019 theory describes aging in terms of epigenetic decline which seems quite different compared to mitochondria-nucleus interaction. Although in both cases decline in NAD plays role. Just questioning how reliable is all these. 4 EK Lim EK Lim 3 years ago (edited) "Dear GP, how to make my heart age slower?" GP: "you should ask a cardiologist" "Dear cardiologist, how to make my intestine age slower?" Cardiologist: "you should ask a gastrologist" "Dear gastrologist, how to make my whole body age slower?" Gastrologist: "you should ask a GP" 16 IW Nunn IW Nunn 2 years ago I don't want to live forever. I just want to be healthy and live an optimum life while I'm in this body. 61 Kevin Fairweather Kevin Fairweather 3 years ago Very succinct explanation ! 1 Command Results Command Results 7 years ago Great talk theorizing the future of mitochondrial development as related to aging and longevity, 2 Mark Sze Chai Chan Mark Sze Chai Chan 6 years ago Thanks it is fascinating! 7 Srtj.Av. Srtj.Av. 2 months ago I love when he smiles as is a good thing happening! 😊 pikiwiki pikiwiki 2 years ago I understood everything! 5 Graeme Gladman Graeme Gladman 1 month ago You need to research vit K2 or and L - Citruline for its anti aging effects. It has wiped my wrinkles and made me years younger. I don't know which one is responsible or it could be a combination of the both. spruceguitar spruceguitar 1 year ago "I do not want to live forever in the memory of the people. I want to live forever in my apartment." Woody Allan 7 GrooveDoctor77 GrooveDoctor77 7 years ago I have tried Niagen about a week ago , Im still sceptical but, I have(had ) 3 loose teeth , but just yesterday I noticed 2 of those teeth have tightened by a large degree , the 3rd tooth is still loose but even that tooth has tightened ..so after week I have hopes that this product is working,(re edit (3/2015) after 2 months of Niagen...I am completely amazed at how well this works, I could list 7 or 8 improvements all over my body ...the most recent amazing thing is..I have been diagnosed diabetic for 5 years, I still eat the same ,.. but I have had to reduce my med intake (I probably will quit Glyburide soon) because my glucose levels were dropping to normal by themselves , I lost 8 lbs of fluid retention after the 2nd week... I am 165 lbs from 173, never realized the bloating in my face & body until I looked at a video from Nov 2014 & compared it to a video I made a couple of weeks ago..1 thing I can say...thanks Dr, Sinclair 12 Blue Jay Blue Jay 2 years ago (edited) what's calcitrol? i saw it in the the Closed Captioning. Mitochondrial Autophagy is caused by Parkin-pink1. Parkin-Pink1 attaches to a receptor on the outter mitochondria membrane. there's 2 types of autophagy. Selective Autophagy from pomegranate's elligic acid and a specific probiotic trigger selective autophagy and universal autophagy from Intermintent fasting. Autophagy is when a damaged mitochondria gets enveloped by a membrane with a libosome. And breaks the mitochondrion into amino acids. to be recycled back into the cell. selective autophagy is the type triggered by high ROS from damaged mitochondria.universal autphagy just autphagies them all, except the Mitochondria. beacause the mutant mitochondria don't.produce ATP. So no ROS by product. to help facilitate the bond of Parkin-Pink1 to the autophagy receptor on the outter membrane. i know South Korea has developed a healthy mitochondria injection method. and England has their mitochondrial donor program for three parent babies. Is there a connection between mitochondrial fuction and telomere? i wonder. 1 C B C B 2 months ago Where did alpha proteobacteria (precursor to mitochondria) come from, and how did they become part of us? How did humans create energy before this happened? Hainet Korea Corporation Hainet Korea Corporation 1 year ago Marine algae.Green seaweed(Chlorophyta) Ulva prolifera is a species of seaweed in the family Ulvaceae that can be found worldwide. Ulva lactuca(linza, pertusa, rigida) etc The pigment comparison of photosynthetic plants and green seaweed. The nine pigments based on chlorophyll in green seaweed are the same as plants. What is the structural color of green seaweed ? It is the color that appeared in the natural physiological and ecological environment when photosynthesis in the earth's environment. Nine Colors:Green,Yellow,White,Pink,Red,red-Purple,(reddish Brown-Brown),Blue,Black. The changes in the color of green seaweed are intended to communication with each other due to environmental conditions.(transformation of chromaticity and breeding of offspring) Who are the ancestor of life on earth ? Genetic and evolution of Earth life.(Eukaryotes: Mitochondria) Mitochondria are Alive:Dried, Bleached, Melted, Rotted(Black) mt DNA: Genetically, it has pigments information and Produces photosynthetic pigments. mt DNA: Nine genetic pigments(Rainbow colors and white, black) Nine melanin pigments(Skin, Eyes, Hair):Human, Marine and Land animals joe schmo joe schmo 5 years ago The body likes to have a 700:1 ratio of NAD to NADH according to a video by Shallenberger. That shows how important NAD is. 2 Kay Halsey Kay Halsey 3 years ago Thank you for the information. 2 Sun Sun 3 years ago sleep, nutrition, movement, absence of stress, good emotions +++ 39 Secret Soul Secret Soul 1 year ago (edited) We dont need to live forever, if we do, we are having lot of problems in coming. Plus we are not dying just bcoz of aging... Pandemic, accidents n killed... We not study aging to live forever Prof, but why aging science is important, its because aging related to many diseases. With our modern unhealthy living styles, we only look for remedies of the damages we have done. Study ageing is my favorite stuff but to live forever... Thats on diff page😂 bcbr bcbr 5 years ago But why do the nuclear and mitochondrial genomes stop communicating in the first place? What causes the nucleus to think that it isn't receiving enough energy? 7 JAMES B. JAMES B. 8 years ago The first NAD+ supplement was just introduced by the same company that developed both the first high potency Resveratrol and Pterostilbene supplements, Biotivia LLC. It is by no means cheap but if it were it would probably not be genuine. The name of the supplement, which is extremely limited at this point in time, is Mitotrans. 2 kittyhooch1 kittyhooch1 2 years ago After this watch a recent video of him. Six years later he is visibly younger. 17 PROCESSOR302 PROCESSOR302 7 years ago You still have to stop cells going into senescence after repeated cellular replication. One way of doing this is to maintain telomere length. 21 Term limits Com Term limits Com 1 year ago (edited) Notice his eyes.... no jaundice like 75% of other people. Also look at his knuckles no edema no tremors and no mandibular deformation from poor dental health..... I trust him. Did you know he wrote a book on this in 2019? 1 Watta Watta 7 months ago some free radicals are good for the body thats probably why u dont wanna remove all of them, but if they do damage dna then maybe thats something to look into tigerkills tigerkills 2 years ago Every medical professionals should learn this. Gerald's Videos Gerald's Videos 2 years ago Thanks for this. Reduce inflammation! 2 Tenerezza jie Tenerezza jie 5 years ago (edited) I have a question.... If communication is so important, why didn't the communication evolve to become more "direct" physically instead of relying on shuttling proteins? Sarge Sarge 2 years ago Isn't there a basic fallacy at work here... if we just learn enough about the tiny details of human health eventually some magic pill or molecule will emerge to fix everything? 3 Hank Nelson Hank Nelson 2 years ago Something much, much bigger is needed, to absolutely be born again. This is a concept that goes beyond the real date of the pyramids. A perfect human is what may very well be locked away in our genes. But first we need to believe that he is there. you r enough 💜 you r enough 💜 3 months ago Intermittent fasting can and will repair your midocondria and clean keto 🥰 Shapan L Shapan L 2 years ago Interesting topic Doctor but it's very theoretical and still no technique or medicine or diet strictly to improve mitochondria function is available. One thing which I never understood about is free radical? According to biochemistry free radical is the driving force to all the enzymes in body to hasten the function so as to remove the free radical itself so in this process the function of the enzymes is constantly active not in silent mode so what if there were no free radical at all in carbohydrate or protein or fat metabolism ,won't the enzymes go in silent mode and since no activity would lead to death. Our body needs stress to stimulate and relaxation to calm down so that's why sympathetic n parasympathetic are created .... So please do make me understand about free radicals Doctor Thankyou 2 Abraham Robles Abraham Robles 2 years ago The mitochondria is the powerhouse of the cell :) 16 فدان فكرت احمد فدان فكرت احمد 5 years ago Thanks it is fascinating 2 Benjamin Hardisty Benjamin Hardisty 7 years ago I do think, however, that there is way too much salesmanship in the aging field in general! That def. perturbs me. 10 Manuel Ojeda Manuel Ojeda 2 weeks ago I just turned 70 and I feel great. Splassshhh1234 Splassshhh1234 1 year ago I like the joy he has 2 Splassshhh1234 Splassshhh1234 1 year ago INCREDIBLE 1 Robert Robert 1 year ago Nice analogy, the mitochondria are all maternal. Perhaps they can be put in an hibernation state.. For space travel! bcbr bcbr 5 years ago But why do the nuclear and mitochondrial genomes stop communicating in the first place? What causes the nucleus to think that it isn't receiving enough energy? 7 JAMES B. JAMES B. 8 years ago The first NAD+ supplement was just introduced by the same company that developed both the first high potency Resveratrol and Pterostilbene supplements, Biotivia LLC. It is by no means cheap but if it were it would probably not be genuine. The name of the supplement, which is extremely limited at this point in time, is Mitotrans. 2 kittyhooch1 kittyhooch1 2 years ago After this watch a recent video of him. Six years later he is visibly younger. 17 PROCESSOR302 PROCESSOR302 7 years ago You still have to stop cells going into senescence after repeated cellular replication. One way of doing this is to maintain telomere length. 21 Term limits Com Term limits Com 1 year ago (edited) Notice his eyes.... no jaundice like 75% of other people. Also look at his knuckles no edema no tremors and no mandibular deformation from poor dental health..... I trust him. Did you know he wrote a book on this in 2019? 1 Watta Watta 7 months ago some free radicals are good for the body thats probably why u dont wanna remove all of them, but if they do damage dna then maybe thats something to look into tigerkills tigerkills 2 years ago Every medical professionals should learn this. Gerald's Videos Gerald's Videos 2 years ago Thanks for this. Reduce inflammation! 2 Tenerezza jie Tenerezza jie 5 years ago (edited) I have a question.... If communication is so important, why didn't the communication evolve to become more "direct" physically instead of relying on shuttling proteins? Sarge Sarge 2 years ago Isn't there a basic fallacy at work here... if we just learn enough about the tiny details of human health eventually some magic pill or molecule will emerge to fix everything? 3 Hank Nelson Hank Nelson 2 years ago Something much, much bigger is needed, to absolutely be born again. This is a concept that goes beyond the real date of the pyramids. A perfect human is what may very well be locked away in our genes. But first we need to believe that he is there. you r enough 💜 you r enough 💜 3 months ago Intermittent fasting can and will repair your midocondria and clean keto 🥰 Shapan L Shapan L 2 years ago Interesting topic Doctor but it's very theoretical and still no technique or medicine or diet strictly to improve mitochondria function is available. One thing which I never understood about is free radical? According to biochemistry free radical is the driving force to all the enzymes in body to hasten the function so as to remove the free radical itself so in this process the function of the enzymes is constantly active not in silent mode so what if there were no free radical at all in carbohydrate or protein or fat metabolism ,won't the enzymes go in silent mode and since no activity would lead to death. Our body needs stress to stimulate and relaxation to calm down so that's why sympathetic n parasympathetic are created .... So please do make me understand about free radicals Doctor Thankyou 2 Abraham Robles Abraham Robles 2 years ago The mitochondria is the powerhouse of the cell :) 16 فدان فكرت احمد فدان فكرت احمد 5 years ago Thanks it is fascinating 2 Benjamin Hardisty Benjamin Hardisty 7 years ago I do think, however, that there is way too much salesmanship in the aging field in general! That def. perturbs me. Mitochondria, Aging, and Health 21,898 viewsJan 11, 2021 Kinexum Services LLC Mitochondria are commonly referred to as the powerhouses of cells because they create the energy necessary for cell function; however, these organelles do much more than that within our bodies. At Targeting Metabesity 2020 (www.metabesity2020.com) this past October, an expert panel led by mitochondrial genetics pioneer Dr. Doug Wallace discussed the key role of mitochondria in aging and health. While other "hallmarks of aging," such as senescence and epigenetics, represent important targets for extending healthy longevity, mitochondrial dysregulation and sequelae, such as inflammaging, are at the heart of the complex of chronic diseases of aging called “metabesity.” Join our panel for an updated dive into one of the major drivers of aging and health. About the Speakers: Douglas Wallace, PhD, is a geneticist and evolutionary biologist at the Children's Hospital of Philadelphia in Pennsylvania, where he serves as Director of the Center for Mitochondrial and Epigenomic Medicine, and holds the Michael and Charles Barnett Endowed Chair in Pediatric Mitochondrial Medicine and Metabolic Diseases. More than 35 years ago, Dr. Wallace and his colleagues founded the field of human mitochondrial genetics, popularizing the concept of the ‘mitochondrial Eve’ from whom all humans alive today are descended. Wallace has a BS in Genetics and Developmental Biology from Cornell and a PhD in Microbiology and Human Genetics form Yale. Francesca Fieni, PharmD, PhD, is the founder and CSO of Pano Therapeutics, a platform biotech company she spun out of UCSF focused on clinical development of drugs targeting mitochondrial ion channels to address complex diseases of aging and extend health span. Francesca earned a PharmD and a PhD in Neuroscience from the University of Modena and Reggio Emilia, Italy and subsequently pursued a postdoctoral fellowship at Massachusetts General Hospital, Harvard Medical School in Boston. She was an independent research associate/specialist at the University of California San Francisco before she turned entrepreneur. Hazel Szeto, PhD, MD, is a research scientist, inventor, and entrepreneur in drug development. She received her MD and PhD in Pharmacology from Cornell and served on the faculty for 37 years. In 2016, Dr. Szeto left to direct research for Social Profit Network, a public charity supporting research to promote healthy aging and reduce age-associated disabilities. Dr. Szeto has developed the first class of compounds that selectively target mitochondria to enhance ATP production, repair mitochondria, regenerate tissues, and restore organ function. These compounds are now in clinical development sponsored by Stealth Biotherapeutics, a company founded by Dr. Szeto in 2006. Dr. Szeto’s research has resulted in over 200 peer-reviewed publications and more than 60 patents. Michael Zemel, PhD, is founder and CSO of NuSirt Biopharma, where he leads research programs focused on energy-sensing and development of therapeutics for diseases of aging and over-nutrition. Previously, he was Professor of Nutrition and of Medicine at the University of Tennessee from 1990-2012, where his work focused on energy sensing, muscle-fat crosstalk, and regulation of adipocyte metabolism. Prior to the University of Tennessee, he served on the faculties of Endocrinology and of Nutrition at Wayne State University and as Research Endocrinologist at the VA Medical Center associated with Wayne State from 1980-1990, where his work focused on endocrine regulation of cell signaling and downstream effects on both blood pressure regulation and insulin sensitivity. Dr. Zemel received his PhD in Physiology and Nutrition at the University of Wisconsin-Madison. 28 Comments