Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder 100,086 views Premiered May 31, 2022

Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder 100,086 viewsPremiered May 31, 2022 FoundMyFitness 422K subscribers The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more – in surprising and possibly unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators. Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 – 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease. Get the show notes at https://www.foundmyfitness.com/episod... 00:00:00 - Introduction by Dr. Dominic D'Agostino 00:03:12 - Intestinal permeability 00:05:20 - Atherosclerosis 00:10:57 - Brain 00:13:16 - Circulating LPS and behavior 00:16:13 - Toll-like receptors and inflammation 00:21:09 - Factors that affect intestinal permeability 00:27:19 - Alcohol 00:29:16 - Gluten 00:32:31 - Butyrate and dietary fiber 00:34:58 - Dietary fat 00:39:31 - Biomarkers for intestinal permeability 00:40:21 - Omega-3 fatty acids 00:47:12 - Questions & Answers LEARN MORE: Coinciding with this release, you can now find a variety of deep resources on the FoundMyFitness website for all of the topics covered in this episode. Learn about the blood-brain barrier: https://www.foundmyfitness.com/topics... Learn about intestinal permeability: https://www.foundmyfitness.com/topics... Learn about toll-like receptors: https://www.foundmyfitness.com/topics... Learn about cerebral small vessel disease: https://www.foundmyfitness.com/topics... SUPPORT THE CHANNEL: Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of this great resource at https://www.foundmyfitness.com/premium . ABOUT THE METABOLIC HEALTH SUMMIT: Over several immersive days, MHS brings together the world’s top experts to present the latest science on a variety of topics related to metabolic health including nutrition, fasting, longevity, cancer, mental health, diabetes, optimizing human performance, the gut microbiome, and more. Learn more about their CME and CPE credited event at https://www.metabolichealthsummit.com . #obesity #endotoxemia #leakygut 216 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 7 days ago (edited) All of the topics covered in today's presentation is available as a deep article on our website. Please make sure to check these resources out. Blood-brain barrier: https://www.foundmyfitness.com/topics/blood-brain-barrier Intestinal permeability: https://www.foundmyfitness.com/topics/intestinal-permeability Toll-like receptors: https://www.foundmyfitness.com/topics/toll-like-receptors Cerebral small vessel disease: https://www.foundmyfitness.com/topics/small-vessel-disease BECOME A MEMBER: Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of this great resource at https://www.foundmyfitness.com/premium . CHAPTERS: 00:00:00 - Introduction by Dr. Dominic D'Agostino 00:03:12 - Intestinal permeability 00:05:20 - Atherosclerosis 00:10:57 - Brain 00:13:16 - Circulating LPS and behavior 00:16:13 - Toll-like receptors and inflammation 00:21:09 - Factors that affect intestinal permeability 00:27:19 - Alcohol 00:29:16 - Gluten 00:32:31 - Butyrate and dietary fiber 00:34:58 - Dietary fat 00:39:31 - Biomarkers for intestinal permeability 00:40:21 - Omega-3 fatty acids 00:47:12 - Questions & Answers 29 Joy Segars Joy Segars 2 days ago Great presentation, Rhonda! As you said, those sea creatures eat algae to get their omega 3s. Please note for your plant based viewers that we can now get vegetarian algae based EPA supplements, and for a long time we have been able to get vegetarian algae based DHA supplements. Thanks for all you do! 7 Nydia Marrero Nydia Marrero 7 days ago Dr. Patrick is able to explain complicated scientific terms into one easy to understand. Thank You Dr. Patrick!!! 56 FoundMyFitness Miss Dashwood Miss Dashwood 6 days ago So thankful for Rhonda and the important information she generously shares with us. Just one thing here - BARLEY contains gluten as does wheat, rye, kamut and spelt to name some commonly consumed grains. 9 Gef Ginn Gef Ginn 7 days ago Great presentation ! I'm going to go back and listen to this one or two more times to make sure I soaked in all the gems of information I am wanting to remember and pass on to family and friends. 22 FoundMyFitness Angie K Angie K 6 days ago Thank you Dr. Patrick. Great lecture! As a registered dietitian, this information was very helpful and pertinent to my practice. During my graduate coursework I came across a study of how cannabinoids play a protective role in intestinal permeability. How does the research stand up today? Is there a benefit for cannabis use in maintaining a healthy gut? 8 Harry Honeycutt Harry Honeycutt 5 days ago Thank You Rhonda! You explain things so well even us chemistry-challenged viewers get it... 4 Nick Lestat Nick Lestat 4 days ago This is it! I had been suffering for years -- but after antibiotics and the time needed to regrow and repair the gut and lining, my body might be pumped with nerves sometimes but it doesn't effect my mental state at all, a while ago I almost got run over while cycling but head remained calm and clear - it's suddenly like i'm james bond or something. 5 Fred Mason Fred Mason 6 days ago Dr. Patrick, amazing breadth of knowledge on this subject. Learned much. 1 Little Voice Little Voice 6 days ago Thank you for sharing this recording of your live talk. It is so useful and means those of us unable to afford the costs of the Metabolic Health Summit can still learn from your wise words 2 brittany.tv brittany.tv 6 days ago Girl you were MADE for this! So blessed by you, your interests and the way you share your information. Much love!! 9 FoundMyFitness Bodyworks Prime Bodyworks Prime 2 days ago Amazing talk! Thanks for uploading it and sharing this with us. Definitely going to give this another listen later. FoundMyFitness Kevin Ryan Kevin Ryan 7 days ago (edited) You are the best, my life has improved because of your first visit on Rogans show!! My blood pressure has improved significantly and every thing else from being pre diabetic to lowering my bad cholesterols and raising my good cholesterols.. Thank you Rhonda 7 FoundMyFitness Carl Watts Carl Watts 3 days ago I have been commenting on various health podcasts to ask to have Kiran Krishnan on. I would especially value your point of view on his assertions concerning leaky gut and its causal role in a variety of disease pathways. And also about his assertions surrounding the effectiveness of bacteria like bacillus subtilis. Have you looked in these studies he has done. Kiran seems very confident and cites studies to back up his case but i would like some more interaction with research scientists like yourself. M. McGui M. McGui 1 day ago I think the comment at 49:00 is pretty relevant. It is more a question of balance than a villain and a good guy Dr. Rhonda Patrick. Many thanks for this great lecture, again. Marco Cee Marco Cee 7 days ago Great video. We're so lucky to have easy access to such information at the click of a button these days 👍 10 FoundMyFitness E I E I 7 days ago Congratulation for the presentation, it is very professional! I also loved the Q&A section! Thank you for spreading these valuable infos 3 FoundMyFitness Jimm Jimm 7 days ago There’s not many Dr’s like you out there. I have been following you since the video sulforaphane. Thank you for sharing your knowledge! 4 FoundMyFitness Tom Solitario Tom Solitario 6 days ago The graphics greatly enhance the presentation. Thank you, Rhonda for adding them to your session. Also, the timeline for the presentation is very useful as your presentations are quite long. It would help all of us viewers if you added recommendations for adjusting life styles, diets, etc. for healthy living and sited in the timeline where those are. Tim Ferris often adds "show notes" after his podcasts to them to enhance the viewer's/listener's experience...Just a thought. Again, thank you. 3 mary oconnor mary oconnor 6 days ago I believe I suffer from certain problems or condition due to the way in which my small intestines function and absorb nutrients etc. I have known of Leaky Gut Syndrome and everything it can cause throughout our entire bodies for a few years now. I am always hoping I could find out more to improve my health and life. I had been(and still am a vegetarian . I was a healthy active , and happy female until 15 years ago,when I had several unexpected lifestyle changes take place. Now , I believe I have bile , liver and intestinal problems , I have ADHD , brain fog at times, fibromyalgia , hypoglycemia ,high blood pressure (which was never above 80/50 anytime during my entire life) and symptoms of celiac disease ,I. believe.. I had hepatitis C but it was treated and has not been detected for 7 years. The only other problems I have had was endometriosis which was removed ,many times because I could not conceive. .After my 2 children were born - I had my Uterus removed. I still have my tonsils and appendix. I find this so very interesting . I wish I could help in some way by volunteering as a subject for your studies if it would be helpful. I'm 68 years old . Good luck with this as I know you are on the cusp of some major breakthroughs. If you can help me with more information I would love to help you in your research. I would also like to become a Member. Thank you for this insight.It is incredibly important and interesting. 2 David Strong David Strong 5 days ago As always amazing content easy to understand. Thank you for all you do !! 2 FoundMyFitness Stan Dupp Stan Dupp 6 days ago I would like to see a video on the daily dozen, foods highest in: Arsenic, Gliadin, Furocoumarins, Cesium, Oxalates, Goitrogens, Serpins, Solanines, Cyanide, Thallium, Bergapten and Pyrrolizidine Alkaloids. Should we keep eating foods high in these 12 or try to find foods that are low in all 12? 2 ctigernews ctigernews 7 days ago (edited) So does this mean taking fish oil capsules 15 minutes after a meal reduces IP because the Omega 3 destroys the LPS peak at one hour? (or something 😅)? 8 BackAlleyGaming BackAlleyGaming 6 days ago there's so many questions i want to ask and so little i understand!! I always believed there's a strong correlation with depression with gut health and the damage anti biotics has done in latent child hood. 1/ My first question is, we know how important butyrate is to gut lining as well as a persons health, wouldn't it be beneficial to take butyrate as a supplement to reduce gut junction and other healthy effects ? 2/ gut inflammation/ stress causes tryptophan to be converted into kynurenine and there's 2 separate interventions of exercise that can salvage the tryptophan into serotonin and kynurenic acid. When should exercise during consumption of foods containing tryptophan be done? before or after consumption to get maximum conversion also for how long? it could change the way we view eating, in Asian cultures it was customary to walk 20 mins after eating to help digest foods. This might actually be an optimisation of serotonin. This can be ground breaking in treatment of depression anxiety. sabin cioflec sabin cioflec 7 days ago 1. I bet LPS is different depending on gut bacteria, also you can add fiber to a diet and increase inflammation in that person -> some people with good gut bacteria will do fine with a ton of sat fat diet and other people will feel shitty. 2. Omega 3s should be taken from pickled fish , i bet any type of heat will destroy the omega 3s that we need. Same goes to animal meat/fat ( especially bone marrow and brain ) but that's a different story. Also AGE's will go through the roof when you cook meat, i'm pretty sure we need to eat it as raw as possible, just like most choline remains in a very soft cooked egg. 3. I think Dr. Zsofia Clemens is the leading entity when it comes to intestinal permeability and she is the leader of the "group" that uses peg400, she would answer a lot of the questions. 7 symq symq symq symq 5 days ago (edited) Dr. Zsófia Clemens has done quite a bit of interesting work regarding intestinal permeability. According to her, the most reliable test is not zonulin or lactulose/mannitol, but PEG400. Edit: Whoops, just noticed this also pops up in the questions at the end. 2 Michael Lowry Michael Lowry 4 days ago I apologize for any offence,none was intended,👍 I respect your ability to explain what you obviously have studied, this is a great presentation. Michael Lowry Michael Lowry 4 days ago Does major head trauma break the blood brain barrier, I actually know the answer I suffered a major head injury to the back of my head with a 6 cm crack of my skull,both my eyes were blood red for about a week. It happened in my youth, I guess my question is not really about this subject,rather the damage to your brain after head trauma, sorry 😳 1 Stephen N Stephen N 7 days ago This was terrific! Thank you Rhonda. 6 FoundMyFitness Pat Williams Pat Williams 4 days ago Thanks Doc....What about glyphosate causing leaky gut? 2 Ketones Not Glucose Ketones Not Glucose 7 days ago The problem is there's way too much farm raised fish out on the market. We need politicians that actually act to get this bacteria induced frankenfish off the market... And it's a global problem! 10 78cheerio 78cheerio 4 days ago Excellent presentation. Thank you Rhonda. FoundMyFitness Fekadu Dereje Fekadu Dereje 6 days ago Dr Patrick, please interview Dr Natasha McBride (neurosurgeon) she has been talking about this issue for more than a decade 2 Deb Murray Deb Murray 4 days ago THREE whole grains that contain gluten: 1. Wheat. 2. Rye. 3. Barley The speaker incorrectly referred to barley as a non-gluten whole grain - Not Correct. 2 Austin Myslinski Austin Myslinski 2 days ago Dr. Rhonda Patrick is my favorite! 1 Ray Kinney Ray Kinney 7 days ago I think it important to try to assess relative nutrient values of particular foods by trying to determine prehistoric evolutionary biologic conditions we have been adapted to over countless thousands of years. Was the beef we ate 30 thousand years ago grass fed, more than grain fed? Seasonality of grazing most likely had cattle eating grass much more than any grain, so we would very likely be better adapted to the complex systems of eating/metabolism of wild grass-eating beef cattle. And since protein poisoning seems to be an important part of how we evolved, prehistoric hunting populations were likely adapted to eating fat beef whenever possible rather than always just eating the leanest cuts of meat. And, eating lots of root carbs as well, to balance the 'rabbit starvation' effects that they had learned needed such balance to keep them healthiest. IMHO 5 Brandon Giarusso Brandon Giarusso 7 days ago Im a covid Long Hauler with extreme high elevations of pro inflammatory cytokines including TNFa and IL-6. Wonder how much leaky gut plays into why I became a long hauler, and many of my symptoms. We also have very high levels of intermediate monocytes, could this be because they are phagocytozing LPS? 5 RWH RWH 5 days ago A small slip up by someone that knows way more than all of us. Barley DOES contain gluten. 1 emlau12 emlau12 7 days ago A typically bloody excellent talk. Thanks. Talia Talia 6 days ago This is an excellent LPS summary for various organs David Strong David Strong 5 days ago As always amazing content easy to understand. Thank you for all you do !! 2 FoundMyFitness Stan Dupp Stan Dupp 6 days ago I would like to see a video on the daily dozen, foods highest in: Arsenic, Gliadin, Furocoumarins, Cesium, Oxalates, Goitrogens, Serpins, Solanines, Cyanide, Thallium, Bergapten and Pyrrolizidine Alkaloids. Should we keep eating foods high in these 12 or try to find foods that are low in all 12? 2 ctigernews ctigernews 7 days ago (edited) So does this mean taking fish oil capsules 15 minutes after a meal reduces IP because the Omega 3 destroys the LPS peak at one hour? (or something 😅)? 8 BackAlleyGaming BackAlleyGaming 6 days ago there's so many questions i want to ask and so little i understand!! I always believed there's a strong correlation with depression with gut health and the damage anti biotics has done in latent child hood. 1/ My first question is, we know how important butyrate is to gut lining as well as a persons health, wouldn't it be beneficial to take butyrate as a supplement to reduce gut junction and other healthy effects ? 2/ gut inflammation/ stress causes tryptophan to be converted into kynurenine and there's 2 separate interventions of exercise that can salvage the tryptophan into serotonin and kynurenic acid. When should exercise during consumption of foods containing tryptophan be done? before or after consumption to get maximum conversion also for how long? it could change the way we view eating, in Asian cultures it was customary to walk 20 mins after eating to help digest foods. This might actually be an optimisation of serotonin. This can be ground breaking in treatment of depression anxiety. sabin cioflec sabin cioflec 7 days ago 1. I bet LPS is different depending on gut bacteria, also you can add fiber to a diet and increase inflammation in that person -> some people with good gut bacteria will do fine with a ton of sat fat diet and other people will feel shitty. 2. Omega 3s should be taken from pickled fish , i bet any type of heat will destroy the omega 3s that we need. Same goes to animal meat/fat ( especially bone marrow and brain ) but that's a different story. Also AGE's will go through the roof when you cook meat, i'm pretty sure we need to eat it as raw as possible, just like most choline remains in a very soft cooked egg. 3. I think Dr. Zsofia Clemens is the leading entity when it comes to intestinal permeability and she is the leader of the "group" that uses peg400, she would answer a lot of the questions. 7 symq symq symq symq 5 days ago (edited) Dr. Zsófia Clemens has done quite a bit of interesting work regarding intestinal permeability. According to her, the most reliable test is not zonulin or lactulose/mannitol, but PEG400. Edit: Whoops, just noticed this also pops up in the questions at the end. 2 Michael Lowry Michael Lowry 4 days ago I apologize for any offence,none was intended,👍 I respect your ability to explain what you obviously have studied, this is a great presentation. Michael Lowry Michael Lowry 4 days ago Does major head trauma break the blood brain barrier, I actually know the answer I suffered a major head injury to the back of my head with a 6 cm crack of my skull,both my eyes were blood red for about a week. It happened in my youth, I guess my question is not really about this subject,rather the damage to your brain after head trauma, sorry 😳 1 Stephen N Stephen N 7 days ago This was terrific! Thank you Rhonda. 6 FoundMyFitness Pat Williams Pat Williams 4 days ago Thanks Doc....What about glyphosate causing leaky gut? 2 Ketones Not Glucose Ketones Not Glucose 7 days ago The problem is there's way too much farm raised fish out on the market. We need politicians that actually act to get this bacteria induced frankenfish off the market... And it's a global problem! 10 78cheerio 78cheerio 4 days ago Excellent presentation. Thank you Rhonda. FoundMyFitness Fekadu Dereje Fekadu Dereje 6 days ago Dr Patrick, please interview Dr Natasha McBride (neurosurgeon) she has been talking about this issue for more than a decade 2 Deb Murray Deb Murray 4 days ago THREE whole grains that contain gluten: 1. Wheat. 2. Rye. 3. Barley The speaker incorrectly referred to barley as a non-gluten whole grain - Not Correct. 2 Austin Myslinski Austin Myslinski 2 days ago Dr. Rhonda Patrick is my favorite! 1 Ray Kinney Ray Kinney 7 days ago I think it important to try to assess relative nutrient values of particular foods by trying to determine prehistoric evolutionary biologic conditions we have been adapted to over countless thousands of years. Was the beef we ate 30 thousand years ago grass fed, more than grain fed? Seasonality of grazing most likely had cattle eating grass much more than any grain, so we would very likely be better adapted to the complex systems of eating/metabolism of wild grass-eating beef cattle. And since protein poisoning seems to be an important part of how we evolved, prehistoric hunting populations were likely adapted to eating fat beef whenever possible rather than always just eating the leanest cuts of meat. And, eating lots of root carbs as well, to balance the 'rabbit starvation' effects that they had learned needed such balance to keep them healthiest. IMHO 5 Brandon Giarusso Brandon Giarusso 7 days ago Im a covid Long Hauler with extreme high elevations of pro inflammatory cytokines including TNFa and IL-6. Wonder how much leaky gut plays into why I became a long hauler, and many of my symptoms. We also have very high levels of intermediate monocytes, could this be because they are phagocytozing LPS? 5 RWH RWH 5 days ago A small slip up by someone that knows way more than all of us. Barley DOES contain gluten. 1 emlau12 emlau12 7 days ago A typically bloody excellent talk. Thanks. Talia Talia 6 days ago This is an excellent LPS summary for various organs Joe L Joe L 1 day ago Caloric restriction does not work, it is extremely temporary as the body adjusts to your intake. Eating a healthy diet is absolutely necessary no grains, as most modern grains are tainted with glyphosate which stops nutrient and enzyme use, how it kills the pests that eat it, not a good idea 1 Mohamed Eassa Mohamed Eassa 6 days ago This channel deserves millions of subscribers in my opinion. 1 FoundMyFitness Rhonda M Rhonda M 7 days ago The hard to find answer is what kind of OTC Omega 3 is actually effective?? I've been taking Krill and recently learned that isn't going to meet the minimum bar but I also hear that most OTC Omega 3 supplements offered on the market are either rancid or contain dosages which aren't effective. If one can't get a doctor's prescription for Omega 3, then where should we be investing our dollars? 5 Appleblade Appleblade 5 days ago 32:50 ... this never made sense to me. It seems to be a justification for eating fiber, but colonocytes are part of our body, they have a blood supply (they both absorb and deposit energy into the blood), so they will get all the energy they need if there is energy in the blood. They might preferentially use the energy from bacteria in the gut (why waste it and deplete the blood of energy?), but that doesn't mean we should be trying to provid