Mitochondria, Aging, and Health 21,721 views Jan 11, 2021

4:13 / 1:50:29 Mitochondria, Aging, and Health 21,721 viewsJan 11, 2021 Kinexum Services LLC Mitochondria are commonly referred to as the powerhouses of cells because they create the energy necessary for cell function; however, these organelles do much more than that within our bodies. At Targeting Metabesity 2020 (www.metabesity2020.com) this past October, an expert panel led by mitochondrial genetics pioneer Dr. Doug Wallace discussed the key role of mitochondria in aging and health. While other "hallmarks of aging," such as senescence and epigenetics, represent important targets for extending healthy longevity, mitochondrial dysregulation and sequelae, such as inflammaging, are at the heart of the complex of chronic diseases of aging called “metabesity.” Join our panel for an updated dive into one of the major drivers of aging and health. About the Speakers: Douglas Wallace, PhD, is a geneticist and evolutionary biologist at the Children's Hospital of Philadelphia in Pennsylvania, where he serves as Director of the Center for Mitochondrial and Epigenomic Medicine, and holds the Michael and Charles Barnett Endowed Chair in Pediatric Mitochondrial Medicine and Metabolic Diseases. More than 35 years ago, Dr. Wallace and his colleagues founded the field of human mitochondrial genetics, popularizing the concept of the ‘mitochondrial Eve’ from whom all humans alive today are descended. Wallace has a BS in Genetics and Developmental Biology from Cornell and a PhD in Microbiology and Human Genetics form Yale. Francesca Fieni, PharmD, PhD, is the founder and CSO of Pano Therapeutics, a platform biotech company she spun out of UCSF focused on clinical development of drugs targeting mitochondrial ion channels to address complex diseases of aging and extend health span. Francesca earned a PharmD and a PhD in Neuroscience from the University of Modena and Reggio Emilia, Italy and subsequently pursued a postdoctoral fellowship at Massachusetts General Hospital, Harvard Medical School in Boston. She was an independent research associate/specialist at the University of California San Francisco before she turned entrepreneur. Hazel Szeto, PhD, MD, is a research scientist, inventor, and entrepreneur in drug development. She received her MD and PhD in Pharmacology from Cornell and served on the faculty for 37 years. In 2016, Dr. Szeto left to direct research for Social Profit Network, a public charity supporting research to promote healthy aging and reduce age-associated disabilities. Dr. Szeto has developed the first class of compounds that selectively target mitochondria to enhance ATP production, repair mitochondria, regenerate tissues, and restore organ function. These compounds are now in clinical development sponsored by Stealth Biotherapeutics, a company founded by Dr. Szeto in 2006. Dr. Szeto’s research has resulted in over 200 peer-reviewed publications and more than 60 patents. Michael Zemel, PhD, is founder and CSO of NuSirt Biopharma, where he leads research programs focused on energy-sensing and development of therapeutics for diseases of aging and over-nutrition. Previously, he was Professor of Nutrition and of Medicine at the University of Tennessee from 1990-2012, where his work focused on energy sensing, muscle-fat crosstalk, and regulation of adipocyte metabolism. Prior to the University of Tennessee, he served on the faculties of Endocrinology and of Nutrition at Wayne State University and as Research Endocrinologist at the VA Medical Center associated with Wayne State from 1980-1990, where his work focused on endocrine regulation of cell signaling and downstream effects on both blood pressure regulation and insulin sensitivity. Dr. Zemel received his PhD in Physiology and Nutrition at the University of Wisconsin-Madison. 28 Comments rongmaw lin Add a comment... L T L T 6 months ago Please put together a podcast with scientists addressing the Western Diet effect on killing mitachondria. Example, Corn Syrup injected in everything. 4 Deffo radio Deffo radio 3 months ago Great work! 1 Viktor Nilsson Viktor Nilsson 1 year ago Great work guys. Very supricing about leucin 2 Mike Frame Mike Frame 10 months ago Dr.Douglas W fielding the question about Gilbert Ling was a special moment. around 1:18:00. Also 1:23:00 the question about EMF...wow. 3 Erwin Rogers Erwin Rogers 2 months ago Love it 🔥 1 thenewapollo thenewapollo 1 year ago @Claude, are you sticking to a dose of 75g of glucose or do you consider bodymass (smurf vs giant) in the administration? Evan Hodge Evan Hodge 11 months ago (edited) Useful fact: 1:45:00 non-panelist comment. HOW to check patient's insulin resistance. Evan Hodge Evan Hodge 11 months ago (edited) Exercise makes you insulin sensitive. Histamine evolved before the adaptive/innate immune system. What can you, in reality, check when you assess your health along the lines of mitochondrial function/energy production? That's the worthwhile question for a normal person. These people want to sell drugs. 3 CartesianColours CartesianColours 5 months ago Please put website links here. First speaker mentions website but it is not clear. Thank you. Hikari 8 Hikari 8 3 months ago (edited) Except Dr. Wallace, the panelists look so unhealthy. How can unhealthy people have any clue as to what makes a human healthy? Compare these people to Dr. Paul Mason, Dr. Brett Scher, Dave Feldman, Elliot Overton, etc. Just as I wouldn't take financial advice from broke people, when it comes to health, I wouldn't put much weight on the opinion of unhealthy people. 2 Timothy Bolton Timothy Bolton 1 year ago Curious - can or will a body take an electron and use it? Like grounding... can your body use an electron from the ground for something like this or does it have to be generated this way and stolen 2 L T L T 6 months ago 42:00 metformin White Light Knight White Light Knight 6 months ago Humans do have brown fat 1 Dino Miles Dino Miles 11 months ago Great , your all so smart . How about you tell us what we can and should do to enhance longevity, health , energy .... blah, blah , blah . Doesn't mean shit , if we cant implement positive change . 3 teleport valorant teleport valorant 10 months ago Hi everyone.If you read this message please read the Holy Quran the direct words and the final message from God.It will guide you to peace truth and happiness in this world and the afterworld with my lovely wishes 3 Dino Miles Dino Miles 11 months ago Junk seience... harmful. 1 Dino Miles Dino Miles 11 months ago Next slide ... yup. Dino Miles Dino Miles 10 months ago Junk ... skip it . These filled are lost . 1