Inactivation and Epigenetics (2017) Etsuko Uno wehi.tv 275,888 viewsJan 25, 2012

Inactivation and Epigenetics (2017) Etsuko Uno wehi.tv 275,888 viewsJan 25, 2012 WEHImovies 161K subscribers X inactivation is a vital process that occurs in all DNA-containing cells of the female body. It is also an important research model and tool for studying epigenetics. Epigenetics refers to processes that tell our cells how, and when, to read the DNA blueprint. The epigenetic regulation of DNA is critical in both normal development and disease. X inactivation is a type of gene dosage compensation. In humans, the sex chromosomes X and Y determine the sex of an individual - females have two X chromosomes (XX), males have one X and one Y chromosome (XY). All of the genes on the Y chromosome are required in male development, while the genes on the X chromosome are needed for both male and female development. Because females receive two X chromosomes, they inherit two copies of many of the genes that are needed for normal function. Extra copies of genes or chromosomes can affect normal development. An example is Down's syndrome, which is caused by an extra copy of part or all of chromosome 21. In female mammals, a process called X inactivation has evolved to compensate for the extra X chromosome. In X inactivation, each cell 'switches off' one of its X chromosomes, chosen at random, to ensure the correct number of genes are expressed, and to prevent abnormal development. Chapters DNA review 0:11 Epigenetics and the X chromosomes 1:34 X chromosomes at molecular resolution 3:03 Inactive X chromosome 4:57 Epigenetic inheritance 6:32 Why is epigenetics important? 9:20 205 Comments rongmaw lin Add a comment... Guoldisney Guoldisney 9 years ago This team are the best molecular biology animators of the world. Not only because the videos look great, but they pay a lot of emphasis in brownian motion, random collisions, molecular twitching and protein overcrowded cell compartments. Being the most accurate artist view of the molecular sized life process, duplicates the beauty. Congrats! 13 Michal Zielinski Michal Zielinski 9 years ago I absolutely love it! A whole lecture of epigenetics in 10 minutes. Hats down! 11 satisfaction2009eBay satisfaction2009eBay 10 years ago These animations are easily the best media productions in the history of the universe. [tear drop] 37 Xakana Xakana 8 years ago This was riveting. This was included in my Epigenetic Control of Gene Expression class. Absolutely fascinating to watch. Thank you! 5 kunal patil kunal patil 5 years ago This was absolutely amazing, with crystal clear explanation, visual and sound effects. The best educational video I have watched so far. Thank you very much! 6 Nikita Gupta Nikita Gupta 5 years ago (edited) This is one of the best channels on YouTube. Great information, great animation, and weird, but great sound effects as well! 5 Brandon LastName Brandon LastName 5 years ago I enjoyed the lecture. Great animation, it helped me visualize what was going on. 9 Thiago Benazzi Maia Thiago Benazzi Maia 6 years ago Amazing work. I can just imagine the time take to made all this thousand atoms dynamics to work for the video. 27 Annika Victoria Annika Victoria 8 years ago Hi WEHI, I was wondering if someone could explain this for me! If a female has an X-linked recessive disease (say that the diseased or mutated gene was on the paternal X-chromosome), will the disease be less severe than if a male had the same disease, because half of her cells will contain active maternal X-chromosomes and inactive paternal X-chromosomes? 14 WEHImovies WEHImovies 10 years ago Thanks everyone! @mdoerkse We use Maya for animation and After Effects for compositing. 16 Aditi Khankhoje Aditi Khankhoje 9 years ago I am so sure...If there were Oscars for bio videos. this would win!! wish u had more such videos...keep it up!! 1 Hans Mack Hans Mack 1 month ago Your videos are so good! Thanks for your scientific and artistic effort! Patrick Kimani Patrick Kimani 7 years ago This is a very good clip. Great in terms of animation and explanation. 1 Abeer Alshehry Abeer Alshehry 8 years ago Great video. Great explanation. Thank you. wubian wubian 8 years ago this is so helpful, it clears everything! Sofía V Sofía V 1 year ago A really well-done video, visual and informative Chantelle Hollingsworth Plowman Chantelle Hollingsworth Plowman 5 years ago Thank you so much. Very helpful (if creepy sound effects - maybe that helped the info imprint on my memory lol). At the point when the egg has both maternal and paternal X chromosomes - before methylation occurs to silence one of the Xs,: DOES Crossover occur at this point (just before the silencing)? 1 Priyanka Sasmal Priyanka Sasmal 4 years ago Thankyou for the detailed information. I liked the animation also. Can you help me solve the doubt which arised .. What happens when their is an X-linked disease in females if one of the X chromosome is inactive? We say that males are more susceptible to the X-linked diseases since they have only one X chromosome and females have another X-chromosome to overcome the defects in one X chromosome.. So how it happens if the other X chromosome is inactive? 1 CoherentRic CoherentRic 11 months ago Brilliant educational video, in combination with such amazing animations. Darlene Estrada Darlene Estrada 6 years ago I love genetics and these types of videos..matter of fact I plan to present my PHD dissertation in this format. Nouri Al-Kadhim Nouri Al-Kadhim 8 years ago Subscribed. Amazing stuff, but I would appreciate it if you go more into details. This is very general and I'm constantly looking for detailed descriptions. 1 Jorge Romo Jorge Romo 2 years ago This video is fraggin' awesome. Thank you so much! 2 TheMarcopolo83 TheMarcopolo83 8 years ago The best video of epigenetic ever, no doubt!! 17 mmcindy33 mmcindy33 10 years ago Thank you for the AWESOME video!! HELPS A LOT!!!!!!! 3 gspb4 gspb4 9 years ago hands down one of the best biology videos 1 Chao Peng Chao Peng 3 years ago Thank you very much! You've saved my final exam! Lejdi J Lejdi J 7 years ago Awesome video and graphics!! great explanation! Thank you 1 Thiên Ngô Quang Thiên Ngô Quang 8 months ago Thanks a lot, I really love the video. Can you guys make another video explain more specific how one X chromosome is inactivated Dvorak Michálek Dvorak Michálek 9 months ago This is blowing my mind. I dont understand like 80% of what hes saying but in highschool these are the questions I wondered but couldnt properly ask. I wanted to see. I wanted to see what was happening. Id ask questions but the teacher would look at me like I was crazy. I love watching these videos. Life is ridiculously complicated Hector Santos Hector Santos 10 months ago (edited) I'm following the playlist "Biomedical Animation by wehi.tv" and I've got to say, this is one of the most amazing and beautiful things I've ever seen. Great work. WEHImovies jto1292 jto1292 10 years ago AMAZING. seriously, this is so useful. the animation is superb!! Gretel A Gretel A 8 years ago This makes me love science even more 1 Hasna Khan Hasna Khan 3 years ago So which comes first: histone tail modifications or de-condensation (allowing TFs and histone modifying proteins to bind)? 2 Roy Javier Roy Javier 2 years ago 2:55 what happens during meiosis, does the inactive X chromosome gets reactivated again? what happens during mitosis, does the inactive X chromosome gets inactivated again in the new cells? 1 Zach Taylor Zach Taylor 1 month ago How can one not be simply fascinated and intrigued by this? Outstanding video. tialicious13 tialicious13 8 years ago great animation! thank you so much! :) huttarl huttarl 9 years ago Very informative. What are the sounds based on? José Carlos José Carlos 8 years ago This is so fantastic! Joseph Nolan Joseph Nolan 3 years ago Excellent video, loved the combination of audio/visual effects paired with the soothing, laconic narrator . Patchouli Knowledge Patchouli Knowledge 1 year ago Can you explain me how does allele gene's interaction of 2 female's X chromosomes work? I mean, if, for example, haemophilla disease appears as an X-linked recessive inheritance and a dominant gene turned up to be in inactivated X chromosome, so how does recessive gene expression can be suppressed by an inactivated gene in allele chromosome? 1 Nouri Al-Kadhim Nouri Al-Kadhim 8 years ago Subscribed. Amazing stuff, but I would appreciate it if you go more into details. This is very general and I'm constantly looking for detailed descriptions. 1 Jorge Romo Jorge Romo 2 years ago This video is fraggin' awesome. Thank you so much! 2 TheMarcopolo83 TheMarcopolo83 8 years ago The best video of epigenetic ever, no doubt!! 17 mmcindy33 mmcindy33 10 years ago Thank you for the AWESOME video!! HELPS A LOT!!!!!!! 3 gspb4 gspb4 9 years ago hands down one of the best biology videos 1 Chao Peng Chao Peng 3 years ago Thank you very much! You've saved my final exam! Lejdi J Lejdi J 7 years ago Awesome video and graphics!! great explanation! Thank you 1 Thiên Ngô Quang Thiên Ngô Quang 8 months ago Thanks a lot, I really love the video. Can you guys make another video explain more specific how one X chromosome is inactivated Dvorak Michálek Dvorak Michálek 9 months ago This is blowing my mind. I dont understand like 80% of what hes saying but in highschool these are the questions I wondered but couldnt properly ask. I wanted to see. I wanted to see what was happening. Id ask questions but the teacher would look at me like I was crazy. I love watching these videos. Life is ridiculously complicated Hector Santos Hector Santos 10 months ago (edited) I'm following the playlist "Biomedical Animation by wehi.tv" and I've got to say, this is one of the most amazing and beautiful things I've ever seen. Great work. WEHImovies jto1292 jto1292 10 years ago AMAZING. seriously, this is so useful. the animation is superb!! Gretel A Gretel A 8 years ago This makes me love science even more 1 Hasna Khan Hasna Khan 3 years ago So which comes first: histone tail modifications or de-condensation (allowing TFs and histone modifying proteins to bind)? 2 Roy Javier Roy Javier 2 years ago 2:55 what happens during meiosis, does the inactive X chromosome gets reactivated again? what happens during mitosis, does the inactive X chromosome gets inactivated again in the new cells? 1 Zach Taylor Zach Taylor 1 month ago How can one not be simply fascinated and intrigued by this? Outstanding video. tialicious13 tialicious13 8 years ago great animation! thank you so much! :) huttarl huttarl 9 years ago Very informative. What are the sounds based on? José Carlos José Carlos 8 years ago This is so fantastic! Joseph Nolan Joseph Nolan 3 years ago Excellent video, loved the combination of audio/visual effects paired with the soothing, laconic narrator . Patchouli Knowledge Patchouli Knowledge 1 year ago Can you explain me how does allele gene's interaction of 2 female's X chromosomes work? I mean, if, for example, haemophilla disease appears as an X-linked recessive inheritance and a dominant gene turned up to be in inactivated X chromosome, so how does recessive gene expression can be suppressed by an inactivated gene in allele chromosome? 1 holyhell5050 holyhell5050 10 years ago Epicgenetics. Absolutely fantastic video! mdoerkse mdoerkse 10 years ago WEHI makes the best quality animations of this type by far! Definitely some nice artistic style and with attention to detail and accuracy. I would like to know what software is used to in the whole workflow to produce these animations? 1 bud ekins bud ekins 7 years ago