Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder 26,184 views Premiered May 31, 2022

SANTA BARBARA Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder 26,184 viewsPremiered M FoundMyFitness 421K subscribers The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more – in surprising and possibly unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators. Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 – 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease. Get the show notes at https://www.foundmyfitness.com/episod... 00:00:00 - Introduction by Dr. Dominic D'Agostino 00:03:12 - Intestinal permeability 00:05:20 - Atherosclerosis 00:10:57 - Brain 00:13:16 - Circulating LPS and behavior 00:16:13 - Toll-like receptors and inflammation 00:21:09 - Factors that affect intestinal permeability 00:27:19 - Alcohol 00:29:16 - Gluten 00:32:31 - Butyrate and dietary fiber 00:34:58 - Dietary fat 00:39:31 - Biomarkers for intestinal permeability 00:40:21 - Omega-3 fatty acids 00:47:12 - Questions & Answers LEARN MORE: Coinciding with this release, you can now find a variety of deep resources on the FoundMyFitness website for all of the topics covered in this episode. Learn about the blood-brain barrier: https://www.foundmyfitness.com/topics... Learn about intestinal permeability: https://www.foundmyfitness.com/topics... Learn about toll-like receptors: https://www.foundmyfitness.com/topics... Learn about cerebral small vessel disease: https://www.foundmyfitness.com/topics... SUPPORT THE CHANNEL: Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of this great resource at https://www.foundmyfitness.com/premium . ABOUT THE METABOLIC HEALTH SUMMIT: Over several immersive days, MHS brings together the world’s top experts to present the latest science on a variety of topics related to metabolic health including nutrition, fasting, longevity, cancer, mental health, diabetes, optimizing human performance, the gut microbiome, and more. Learn more about their CME and CPE credited event at https://www.metabolichealthsummit.com . #obesity #endotoxemia #leakygut Chapters Introduction by Dr. Dominic D'Agostino 0:00 Intestinal permeability 3:12 Atherosclerosis 5:20 Brain 10:57 Circulating LPS and behavior 13:16 Toll-like receptors and inflammation 16:13 100 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 1 day ago (edited) All of the topics covered in today's presentation is available as a deep article on our website. Please make sure to check these resources out. Blood-brain barrier: https://www.foundmyfitness.com/topics/blood-brain-barrier Intestinal permeability: https://www.foundmyfitness.com/topics/intestinal-permeability Toll-like receptors: https://www.foundmyfitness.com/topics/toll-like-receptors Cerebral small vessel disease: https://www.foundmyfitness.com/topics/small-vessel-disease BECOME A MEMBER: Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of this great resource at https://www.foundmyfitness.com/premium . CHAPTERS: 00:00:00 - Introduction by Dr. Dominic D'Agostino 00:03:12 - Intestinal permeability 00:05:20 - Atherosclerosis 00:10:57 - Brain 00:13:16 - Circulating LPS and behavior 00:16:13 - Toll-like receptors and inflammation 00:21:09 - Factors that affect intestinal permeability 00:27:19 - Alcohol 00:29:16 - Gluten 00:32:31 - Butyrate and dietary fiber 00:34:58 - Dietary fat 00:39:31 - Biomarkers for intestinal permeability 00:40:21 - Omega-3 fatty acids 00:47:12 - Questions & Answers 21 Nydia Marrero Nydia Marrero 1 day ago Dr. Patrick is able to explain complicated scientific terms into one easy to understand. Thank You Dr. Patrick!!! 29 FoundMyFitness Gef Ginn Gef Ginn 1 day ago Great presentation ! I'm going to go back and listen to this one or two more times to make sure I soaked in all the gems of information I am wanting to remember and pass on to family and friends. 14 FoundMyFitness Miss Dashwood Miss Dashwood 6 hours ago So thankful for Rhonda and the important information she generously shares with us. Just one thing here - BARLEY contains gluten as does wheat, rye, kamut and spelt to name some commonly consumed grains. 3 Little Voice Little Voice 3 hours ago Thank you for sharing this recording of your live talk. It is so useful and means those of us unable to afford the costs of the Metabolic Health Summit can still learn from your wise words Brandon Giarusso Brandon Giarusso 1 day ago Im a covid Long Hauler with extreme high elevations of pro inflammatory cytokines including TNFa and IL-6. Wonder how much leaky gut plays into why I became a long hauler, and many of my symptoms. We also have very high levels of intermediate monocytes, could this be because they are phagocytozing LPS? 4 Marco Cee Marco Cee 23 hours ago Great video. We're so lucky to have easy access to such information at the click of a button these days 👍 5 FoundMyFitness Stephen N Stephen N 1 day ago This was terrific! Thank you Rhonda. 4 FoundMyFitness Tom Solitario Tom Solitario 8 hours ago The graphics greatly enhance the presentation. Thank you, Rhonda for adding them to your session. Also, the timeline for the presentation is very useful as your presentations are quite long. It would help all of us viewers if you added recommendations for adjusting life styles, diets, etc. for healthy living and sited in the timeline where those are. Tim Ferris often adds "show notes" after his podcasts to them to enhance the viewer's/listener's experience...Just a thought. Again, thank you. 2 E I E I 1 day ago Congratulation for the presentation, it is very professional! I also loved the Q&A section! Thank you for spreading these valuable infos 2 FoundMyFitness Jimm Jimm 19 hours ago There’s not many Dr’s like you out there. I have been following you since the video sulforaphane. Thank you for sharing your knowledge! NN NN 3 hours ago Thank you for all you do Dr. Patrick. Would you be able to do a video on the latest studies of mRNA vaccines and if it is showing to be able to cross the blood brain barrier. Also, what the latest information is on mRNA and if it is changing the DNA in the liver. ctigernews ctigernews 1 day ago (edited) So does this mean taking fish oil capsules 15 minutes after a meal reduces IP because the Omega 3 destroys the LPS peak at one hour? (or something 😅)? 5 sabin cioflec sabin cioflec 1 day ago 1. I bet LPS is different depending on gut bacteria, also you can add fiber to a diet and increase inflammation in that person -> some people with good gut bacteria will do fine with a ton of sat fat diet and other people will feel shitty. 2. Omega 3s should be taken from pickled fish , i bet any type of heat will destroy the omega 3s that we need. Same goes to animal meat/fat ( especially bone marrow and brain ) but that's a different story. Also AGE's will go through the roof when you cook meat, i'm pretty sure we need to eat it as raw as possible, just like most choline remains in a very soft cooked egg. 3. I think Dr. Zsofia Clemens is the leading entity when it comes to intestinal permeability and she is the leader of the "group" that uses peg400, she would answer a lot of the questions. 5 Ray Kinney Ray Kinney 1 day ago I think it important to try to assess relative nutrient values of particular foods by trying to determine prehistoric evolutionary biologic conditions we have been adapted to over countless thousands of years. Was the beef we ate 30 thousand years ago grass fed, more than grain fed? Seasonality of grazing most likely had cattle eating grass much more than any grain, so we would very likely be better adapted to the complex systems of eating/metabolism of wild grass-eating beef cattle. And since protein poisoning seems to be an important part of how we evolved, prehistoric hunting populations were likely adapted to eating fat beef whenever possible rather than always just eating the leanest cuts of meat. And, eating lots of root carbs as well, to balance the 'rabbit starvation' effects that they had learned needed such balance to keep them healthiest. IMHO 3 Kevin Ryan Kevin Ryan 23 hours ago (edited) You are the best, my life has improved because of your first visit on Rogans show!! My blood pressure has improved significantly and every thing else from being pre diabetic to lowering my bad cholesterols and raising my good cholesterols.. Thank you Rhonda 3 Timothy Hennigan Timothy Hennigan 1 day ago Good stuff Dr. Rhonda Patrick. 2 FoundMyFitness Pedro Lavigne Pedro Lavigne 23 hours ago Dr Paul Mason gave a succinct and clear presentation on this topic a few years back 1 emlau12 emlau12 18 hours ago A typically bloody excellent talk. Thanks. Christopher Smith Christopher Smith 1 day ago Thank you Dr. Patrick! 2 FoundMyFitness Monica Broniecki Monica Broniecki 9 hours ago Hoping that you see this question: when LPS has crossed the blood brain barrier and caused damage, is the damage caused likely to be permanent? In other words, will I have to live with the sins of the past? Talia Talia 4 hours ago This is an excellent LPS summary for various organs How To Sand A Floor How To Sand A Floor 21 hours ago Absolute gold, as usual jayalanlife jayalanlife 18 hours ago 1st great eye opener and well elucidated. I will stick flax for O3 because I don't like tablets and not sure if thay have been heat treated, in Japan they consume fish raw but again I'm not accustomed to raw. Your thoughts would be greatfully received. Cheers Alan youtubeweber youtubeweber 22 hours ago Hey, Dr. Patrick. Thanks to you, I’ve had big green smoothies 6 days a week for the past 5 years. Rhonda M Rhonda M 1 day ago The hard to find answer is what kind of OTC Omega 3 is actually effective?? I've been taking Krill and recently learned that isn't going to meet the minimum bar but I also hear that most OTC Omega 3 supplements offered on the market are either rancid or contain dosages which aren't effective. If one can't get a doctor's prescription for Omega 3, then where should we be investing our dollars? 3 Dana Pearson Dana Pearson 1 day ago Glad Rhonda's BACK! 8 FoundMyFitness Jan Jileček Jan Jileček 1 day ago Great talk. The last question is cut off though, what was it about? steve myers steve myers 1 day ago trailer is the best promo you can do - well done! 3 FoundMyFitness S K S K 1 day ago I have leaky gut issues. I will be tuned:) thanks 4 FoundMyFitness JRR31984 JRR31984 1 day ago Very GOOD video title, "intestinal permeability"-- like meiosis and mitosis. (a big duh) 7 Yama Nosu Yama Nosu 1 day ago I'm genuinely so excited to see this haha. I have like 3 alarms setto remind me 😂 4 FoundMyFitness Dmitry Agafonov Dmitry Agafonov 1 day ago Excellent! 1 FoundMyFitness uelude uelude 5 hours ago Rhonda.. Do you think it's unwise to have high levels of glutathione / antioxidants daily? Increasingly there are warnings due to pushing the balance to far towards antioxidants to the detriment of vital oxidant related signaling. The 'youtube space' is crying out for some wisdom on this underrepresented and misunderstood balance. SioLazer SioLazer 17 hours ago Dr. D'Agostino introducing you is a way cool power stance. Dig it! FoundMyFitness Alex McMahon Alex McMahon 16 hours ago Does ALA have the same impact on gut health as DHA and/or EPA in terms of permeability or do they all behave differently? Tom Bunker Tom Bunker 6 hours ago No mention that Omega 3's DHA and EPA at least, induce the cellular housecleaning of Autophagy. That may be the main reason for the health benefits of Omega 3's. Taking Fish Oil every day may not be the optimum way to health. I would suggest that Omega 3 consumption weekly may be better. Boden Boden 18 hours ago Well done Tom Solitario Tom Solitario 8 hours ago Rhonda highlights that sardines are a good source of fatty acids. But are canned sardines, which, I'm guessing, are highly processed, are they a good source of Omega fatty acids or has all the nutrition been "leached" from the fish in processing them for canning? 1 Scottish Fold Mocha Scottish Fold Mocha 1 day ago 33:22 - sources of fermentable fiber - you forgot to include my favorite - acacia fiber 1 Ketones Not Glucose Ketones Not Glucose 14 hours ago The problem is there's way too much farm raised fish out on the market. We need politicians that actually act to get this bacteria induced frankenfish off the market... And it's a global problem! 2 Martin Tippins Martin Tippins 14 hours ago (edited) Mixture of science and fashionable nutrition advice. But there ARE many papers about LPS btw. Its a hot topic. sCiphre sCiphre 10 hours ago Who is the mansplainer at 49:00? Very interested in his research on LPS, he had some interesting points. 1 Mel Mel 20 hours ago I just need a daily eating plan for the year. 1 Boden Boden 19 hours ago About the heavy cream, consider casine and its exorphins. alice coppers alice coppers 1 day ago As a person over 65 who has been a vegan and used alternative medicine on my life I do not have gray hair and I do not wear glasses. I am in better shape than most 30-year-old as I do martial arts and compete with a lot younger people. When you look at different societies and their mortality rates America’s falling while Asian countries their life spans are increasing. If you want quality of life diet is the key otherwise you can spend your lifetime visiting doctor offices. 1 mark veen mark veen 1 day ago (edited) (Super)Centenarians having very low markers of inflammation and even bloodsugar. It might be good to note that this has little or nothing to do with lifestyle and diet. Seems to be almost entirely genetic. Simply said: just better (DNA)repair and bulletproof immune system carries you to extreme longevity. Whole grains lower inflammation. Sure, if there isn't any glyphosate there. US? Choose your grains wisely. Here in europe where I live almost everyone eats grains without any problem. Alot of oats, barley, rye, spelt and not so much wheat. Higher Omega3 and Vit.D is again lower inflammation and autoimmune issues. Translates to better immune system, health and longevity. 5 Ron Laduke Ron Laduke 1 day ago I would love to see Dr Rhonda interview with Dr Gundry? 3 EatVeganHelpEarth EatVeganHelpEarth 21 hours ago (edited) Interesting talk. One thing you claim "low Omega-3 intake from seafood" as a significant cause of preventable death, while intimating that plant sources are not adequate sources. But your citation doesn't deal with the question of sources of Omega-3's and their effect on mortality. Rather, after the 1st use of the word Omega-3, the 2009 research paper puts the word "seafood" in parenthesis - kind of like using the word protein and putting the word meat after. Pedro Lavigne Pedro Lavigne 23 hours ago Consistent with the findings published by ICMNI a while back Sheik Daddy Sheik Daddy 1 hour ago (edited) There are studies to show that when fat and carbohydrates are combined there is an increased fat storage over when they are isolated. Insulin opens up the key that allows the fat to go in. I say this because ask yourself what foods in nature exist that have close to or equal proportions of fat and carbohydrates and protein? The answer is milk something that is designed for growing bodies and that a lot of people become intolerant to the sugar of overtime. There is no food in nature other than this that intended to for us to be combining these macro nutrients. you can find protein and carbs you can find protein and fat you cannot find carbs and fat and you can definitely not find all three in close to equal proportions outside of milk. Cashews and pistachios would be the closest and they are not close to being equal in ratio. As much as omnivore is logical we don't understand the interactions that the stomach has to deal with at the same that it's never had to deal with before in the history of humans. Add to that all of the fake junk food on top of it. Greg Johnson Greg Johnson 3 hours ago The presentation refers to Pendyala S. Walker JM. Holt PR A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology. 2012;142(5):1100-1101 e2. doi l 0.1053/j gastro 2012.01.034. I searched for this and could not find out what they considered a Western Diet (High-Fat.) This was likely a diet high in inflammatory seed oils which would trigger those results. It might not be high fat that is the culprit, but the type of fat. Bobby Ocampo Bobby Ocampo 20 hours ago What happens if you remove grains from your diet? Chris Bent Chris Bent 1 day ago (edited) Ok, I just have to ask this... why is there such a killer anime-cyberpunk intro with smoothly animated machinery to this talk? I love it but I legitimately don't understand. Xensonar Xensonar 1 day ago I love hearing all the different ways I'm gonna be f**ked when I'm old. 10 Patrick Nugent Patrick Nugent 21 hours ago Follow the science Rhonda , not your confirmation bias. Whole grains are an excellent foods, fats not so good outside of their fibre matrix. Ketogenic diets elitist unsustainable and a disaster for the planet. Love your work on the whole . 2 Rui-9-CS Rui-9-CS 20 hours ago nice! Linda Ripp Linda Ripp 4 hours ago Thanks Scottish Fold Mocha Scottish Fold Mocha 1 day ago (edited) 52:42 - young gentleman? Is that a hint that the lady who is asking question is NOT young? Bobby Ocampo Bobby Ocampo 20 hours ago What happens if carnivore Diet? Macaron Afterparty Macaron Afterparty 15 hours ago 49:02 Is this "mansplaining"? lol Fluffy Hamster Fluffy Hamster 6 hours ago Keto Num Nuts.. ImTryingHere ImTryingHere 9 hours ago 49:25 tommy wood in the house B B64 B B64 21 hours ago 2:29