AKG (Rejuvant) reverses biological age in humans – BUT, what you must know. 63,798 viewsDec 1, 2021 The Sheekey Science Show 27K subscribers “Remarkably, individuals showed an average decrease in biological aging of 8 years” This week in the journal Aging-US, we get a look at the first data of Rejuvant, an alpha ketoglutarate (AKG) based formulation, in human patients. It was previously shown in a study that AKG supplementation increases the lifespan of the worms C.elegans and I reported on the study that came out last year showing that the calcium-salt of AKG extended both the lifespan and healthspan of mice. In this publication they show 42 participants take Rejuvant and used DNA methylation (epigenetic age) to assess their "biological age". The data shows it conferred an average 8 year reduction in biological aging, after an average of 7 months of use. In this video we will break down this paper completely, address exactly what the data shows, what it doesn’t show and what I think the take homes are? We'll also discuss the limitations such as lack of clinical markers and no placebo group!! Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?coun... through Patreon - https://www.patreon.com/TheSheekeySci... TIMESTAMPS: Intro - 00:00 Alpha ketoglutarate - 00:30 Human data & age reversal - 1:30 Limitations - what you must know - 05:30 REFERENCES: Demidenko O, Barardo D, Budovskii V, Finnemore R, Palmer FR, Kennedy BK, Budovskaya YV. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (Albany NY). 2021; 13:24485-24499. https://doi.org/10.18632/aging.203736 Icons in intro; "https://www.freepik.com/free-photos-v... "Background vector created by freepik - www.freepik.com 261 Comments rongmaw lin Add a comment... The Sheekey Science Show Pinned by The Sheekey Science Show The Sheekey Science Show 6 months ago I probably should've mentioned that a larger clinical trial is being conducted in Singapore using AKG and looking at more measurements (Prof Brian Kennedy) so hopefully we will get more data soon! 110 David Pereira David Pereira 5 months ago (edited) Always a catch, looks really promising. Would be great for there to be an independent trial and confirm physical and cognitive improvement if any! Great piece, thanks! 21 The Sheekey Science Show Waylon Flinn Waylon Flinn 5 months ago Interesting to note that the lines on the delta graph basically have two different slopes. One group saw moderate improvement the other saw much more pronounced improvement. Would be very interesting to see if a relevant variable could be identified to distinguish them. 7 Talia Talia 4 months ago (edited) Thanks for this video. My friend tried it but said it had 0 effect on his running speed or ability (as a functional indicator). Like myself and a lot of females, bodybuilding benefit isn't really of interest to me. I liked the fact you touched on methylation biomarkers as not necessarily indicators of true clinical functionality. 4 Lei Zhang Lei Zhang 4 months ago Also there is no control group to compare the measurements against, there should be a group where they measure before and after 7 months to see what the changes are in DNA methylation. There also needs to be peer reviewed, 42 is also not a big number although statistically it's significant enough to predict normally distributed behaviors to 95% confidence levels, but this is assuming aging improvements are normally distributed through AKG supplements. This also needs to be replicated multiple times as well, double blind test...this isn't rigorous enough for scientific publication. 6 Ben M Ben M 5 months ago Good video, I'd like to see more clinical trials and papers, but let's hope it's not just their sales pitch 6 Richard Breeze Richard Breeze 6 months ago (edited) There was another study recently that came to light that suggested that an 8 week healthy diet reduced epigenetic age by 1.7 years or so. Push the timeline forward that suggests that in 1 years of a healthy diet / lifestyle / supplement tweaks you become 10 years younger and in 4 years I would be a baby again. To be frank these claims a bordering on ridiculous and far too good to be true. They are crunching the data in a sensationalist way I don't buy it for one second. We can't move forward if we clutch hold of nonsense. I'm deeply suspicious of who funded the study and why it was conducted. I am happy to be wrong about this but I doubt anyone is gonna make my day anytime soon. 10 Marco Zolo Marco Zolo 5 months ago There's actually something alot simpler you can take now that also does pretty much the same thing. And it doesn't have to be some chemical concoction, you can take it right away too and have impressive results on skin, digestive health and increased cell apoptosis and anti inflammatory. And it's... Ginger You're welcome 10 Ciprian Todoran Ciprian Todoran 6 months ago With all the shortcomings considered (not placebo controled and non assement of some functional data being more serious, the others - I don't see them as important), I think this is an important study as it points to something else than NAD+ boosters. Thank you for this post. 13 Mike Guetta Mike Guetta 5 months ago The arginine salt of AKG is sold quite cheaply as a bodybuilding supplement. Can anyone think of a reason why this wouldn't be just as effective as the calcium salt? 19 Olav Thorsen Olav Thorsen 3 months ago David Sinclair "My biological age is 38" Me: "Why do you look like a more frail version of Mr. Burns?" David: "Oh I don't engage in vigorous exercise because it reduces your life span." Chasing a drug to make you younger as you decline right into your grave is not a good anti-aging strategy at the moment. Want to stave off old age? Exercise HARD, and eat clean. 2 Blurns Blurns 6 months ago Discovering that these markers could simply be reversed by the placebo effect would also be an amazing finding. 29 Chris Gauthier Chris Gauthier 5 months ago Well done. I appreciate your approach of presenting the paper as objectively as possible, then providing logical critique. Your points were spot on, specifically the lack of control and the choice of methylation test. I am largely unfamiliar with attempts to connect methylation with aging, as I have focused most of my attention on methylation, environment, and inherited traits. Is there much data linking methylation and aging? Is it showing cause or coincidence? Thank you again! Great video! 2 The Sheekey Science Show Mark Lloyd Mark Lloyd 5 months ago ONE CONCERN: Is calcification of the arterial walls a possible danger with the Ca-AKG (Calcium Alpha-Ketoglutarate) supplements because there is a lot of caution with this possibly being the case with other calcium supplements? 9 Kevin Street Kevin Street 4 months ago Thank you for this video! I found it very informative. Peter Peter 6 months ago Thanks Eleanor. Yes the placebo effect, which can be powerful, needs to be accounted for. Would like to see how this stacks up against the diet/lifestyle study done by Kara Fitzgerald., which seem to show age reversal over a much short intervention. 4 The Sheekey Science Show CoherentRic CoherentRic 6 months ago As always interesting talk, keep up the great work! Must be difficult getting funding without some sort of commercial finance. Interesting that potentially long term use, the body may get use to its affect. So rotating various "medications" could negate that perhaps. Many thanks. 👍 2 The Sheekey Science Show bob person bob person 5 months ago I think one if the most exciting things in this study is your mention that placebo could possibly ALSO be a cause of age-reducing markers! 3 Abdelilah BENAHMED Abdelilah BENAHMED 6 months ago Thx for this another great video. I wonder if a better strategy would be to focus on reducing circulating insulin and glucose through a healthy diet, intermittent fasting and exercise. 8 Nick's DIY Nick's DIY 5 months ago More testing is needed as usual. But maybe this is moving in the right direction. Johnny Rocket Johnny Rocket 5 months ago So what would happen if you were to take a AKG supplement like Rejuvant and a NAD supplement together? Would you see even better results? 14 Andrew Taylor Andrew Taylor 6 months ago (edited) Does simply changing the DNA methylation pattern truly reduce aging? The pattern is correlated with age, but the AKG intervention may itself change the correlation. This study is not at all convincing. 15 1000imps 1000imps 6 months ago Wow i just put this paper to my to read list and here you are already making video! Great work 4 The Sheekey Science Show Vetruvio Vetruvio 6 months ago Very excited that this study was finally done on humans, very slow progress in this direction taking into account that similar study on nematode worms was done almost 10 years ago. I am wondering if longevity effects are related to the ability of α-Ketoglutaric acid to bind ammonia therefore helping body to detoxify metabolic byproducts. 4 Tony Sanders Tony Sanders 5 months ago Thank you very thought out and thorough Sergio Perez Melo Sergio Perez Melo 5 months ago Someone should do a randomized placebo controlled trial using Arginine Alpha Ketoglutarate which is cheaper but has shown effectiveness in antiaging in other species 11 Cancer Research Demystified Cancer Research Demystified 5 months ago Well this is just awesome, thanks for sharing! 1 The Sheekey Science Show Ioan Marian Danila Ioan Marian Danila 5 months ago (edited) AKG is ,,known substrate for DNA demethylases”... I wonder if demethylases distinguish between tumor supressor genes and oncogenes. 1 Battery9876 Battery9876 5 months ago Since it extended lifespan in mice, it's really a good sign. 2 Don Watson Don Watson 5 months ago AKG has been a great benefit to me it's has a calming effect on my heart. 6 mcgeebag1 mcgeebag1 6 months ago I was listening to Peter Attia's podcast recently and was surprised to here him say where are no good biomarkers for aging. I know that dna methylation clocks aren't perfect, but I was under the impression that they were pretty good?! Also do you take a AKG supplement? 12 Jami Carpenter Jami Carpenter 6 months ago Would like to see a study done by anyone NOT motivated by financial gain , which will always be discounted in my book. 32 The Sheekey Science Show RustyCobalt RustyCobalt 6 months ago Vindication!! Been taking AAKG for mitochondrial benefits for almost two years. Probably too young to have noticable de-ageing effects but can confirm I feel and train orders of magnitude better in most all capacities 5 SpaghettiToaster SpaghettiToaster 5 months ago Is it not possible that AKG directly influences methylation? Were possible mechanisms for this proposed in the paper? After all, it seems much more plausible that a medication would directly affect the methylation sites that they happened to measure rather than literally reverse aging, which would mean having targeted and positive effects on a huge number of pathways, many more than would be required to just affect DNA methylation. Doesn't Occam's razor favor the latter hypothesis until proven otherwise? 1 frank brown frank brown 6 months ago Any word on how long it will take Brian Kennedy to confirm this? 8 years seems highly significant and one would think there would be an army of researchers attempting to prove or disprove, and also raising the Q why limit the research to the expensive calcium version? 2 N. F. N. F. 5 months ago What’s with the vitamin A and D? I thought men benefit from equal if not greater vitamin D levels and women don’t have vastly different vitamin A requirements from men. Couldn’t the inclusion of either also compromise the findings since they could just be treating deficiencies or whatever. Hope I’m missing something and/or this isn’t the only formulation that’s been used in high-profile Ca-AKG research (though since Rejuvant keeps funding it…) 2 TnT FoX TnT FoX 5 months ago A healthy diet cutting out heavy drinking, overly rich foods and drugs in general will 'reduce' your age from a health standpoint too. I highly doubt there is a wonder pill to replace a healthy lifestyle, just like the 'too good to be true' weight loss programs also require diet changes. Taking supplements and changing to a healthy diet has always improved people's health. Let's get to that stuff they used to make an old rat look young. 1 mrpmac mrpmac 5 months ago I take 1g AKG every morning cuz it helps with my energy & concentration. Does anyone get the same results? or is this just a placebo effect? nick dmo nick dmo 5 months ago I'm considering starting to take MNM, TMG, and. AKG. Is there any worries that any of these will have an adverse effect on me. I had a bi-cuspid aortic valve replaced and I now take Warfarin. I can't find any information, and would like to make an informed decision before trying these. 1 Sid Masey Sid Masey 5 months ago I thought it was normal practice for pharma companies to fund studies for their products. It makes sense that they want the scientiric proof of claims as a selling point. If the results aren't the ones they want though, must they still publish and submit to peer review? jopalolive jopalolive 5 months ago I like the fast pace of your video presentation. 1 The Sheekey Science Show jack buaer jack buaer 6 months ago (edited) Okay, so this is odd. I read this comment about rejuvant from over a year ago on the age reversal network "The speaker presented a talk indicating that users got substantial drop in DNA methylation age results - I seem to recall an average of 8 years after 6 months usage" Either Rejuvant has been sitting on this data at least since 5/1/2020 or they just happened to repeat previous study results almost exactly. Or maybe it's totally normal to first publish results more than one year after a study has been completed? 3 matt jensen matt jensen 3 months ago aKG blocks ATP synthase preventing APT, increasing ADP and there by AMP, The main cause of lifespan increase from fasting or exercise Lance Hitchings Lance Hitchings 6 months ago It's pretty interesting, but I'm really following Brian Kennedy. I think his trial will be more definitive. However, Brian is also an author on this paper. 4 The Sheekey Science Show ctguitarguy85 ctguitarguy85 5 months ago I wonder if their were any benefits to things like blood sugar/a1c? Henvest Henvest 5 months ago I have been taking arginine akg (aakg) for several months. Does anyone know if this will give the same results. Its so much cheaper than calcium akg 1 Rapamycin News Rapamycin News 6 months ago Interesting, but all biomarkers of aging tests are not well tested, or compared or qualified - so this is not a ton of value. Did they use a bunch of different biomarker tests and just show the one that showed the best result? 3 The Sheekey Science Show Izzers Tennis Score Keeper Izzers Tennis Score Keeper 6 months ago I have taken AKG every am, first thing, for about a year. I like. Glenn Robin Glenn Robin 6 months ago I'm confused on the desire for a placebo group, are we suggesting that knowing or not knowing what is being taken will change the results? If that is the case then it's the power of the mind and not the supplement? 1 mark martin mark martin 6 months ago I’ve been taking AAKG for about 10 months. I’m 65. Male. I’ve found I put on more muscle and less fat but the only side effect perhaps is my feet. I have pain on the outside of my right foot which I suspect is calcium deposits though I have not been to a doctor. I suspect the AAKG causes an accumulation of calcium in some way. 3 Jef Leopard Jef Leopard 5 months ago (edited) I don’t care about living longer. I care about living younger. I’m looking for 15-30 years younger in looks, feel, and energy. 2 danny iskandar danny iskandar 6 months ago how do we see this intervention vs the others like: NMN, Resveratol, exercise, fasting, etc. How do we make sense out all this longevity intervention? Should we try it all at the same time? What do you guys think? Are any of those has a negation effect over the others? 1 Shambhavee Mishra Shambhavee Mishra 5 months ago Hey Hii sheekey with all confusions around 😬 can you tell us some natural ways to boost ca-AKg or is there any way....!!!! 1 HeroC14 HeroC14 4 months ago Humankind cannot gain anything without first giving something in return. To obtain, something of equal value must be lost. That is alchemy's first law of Equivalent Exchange. basspig basspig 5 months ago Is this product available to centenarians? Chris Marks Chris Marks 6 months ago 900mg /day of Vit A in the male arm of the study seems very high, when the Mayo Clinic RDA is just 900mcg. RelevantGames RelevantGames 4 months ago (edited) But how would a placebo pill remotely or even conceivably reduce methylation or even someone's biological clock? I guess my question is, should you even bother with placebo controlled studies in certain instances, for example this one? Would love to hear a response :) AI AmI? AI AmI? 5 months ago So did the mice live twice as long? Scientific study my ares... 😁 brugna456 brugna456 5 months ago The only use of this study is to motivate other researches to do a proper placebo controlled study. As it stands now it's pure marketing so they can slap "according to research..." on their website and products. The Sheekey Science Show Pakistanicecream Pakistanicecream 6 months ago Good video. The Sheekey Science Show Screaming Fly Productions LLC Screaming Fly Productions LLC 5 months ago I can't wait to be 21 again. :) Nunya Beezwax Nunya Beezwax 5 months ago I found that you can buy the same product MUCH cheaper.... And without the weird DNA test bs or hype. Same dosage too, 1000mg of Calcium Alpha Ketoglutarate! 4 Scott Preston Scott Preston 2 months ago I'm pessimistic. As time goes on, none of these scientists are looking good, ☠but the mice are beautiful. 1 Darkhorseman82 Darkhorseman82 5 months ago (edited) It helps correct the amino acid imbalance which causes cascading failures in aging, and contr