Mitochondrial Health - ASPEN 2021 10,698 viewsApr 27, 2021 Nestlé Nutrition Institute

The Role of Nutrition Care In Mitochondrial Health - ASPEN 2021 10,698 viewsApr 27, 2021 Nestlé Nutrition Institute 8.74K subscribers The role of the mitochondria is pivotal to maintenance of robust cellular function in health and disease. This program reviews the clinical impact of changes in cellular health and the role of nutrition intervention in supporting mitochondrial function through aging and various disease states. RDs and DTRs practicing in the US may log CPE activities under Activity Type 175 for up to three years from the original presentation date. This program is eligible for 1.5 CPEUs. The activity number for viewing this recording through March 19, 2024 is 162814 (level 2). To learn more about submitting this activity type visit https://www.cdrnet.org/new-recorded-p... To obtain a CE certificate, login or register at www.nestlemedicalhub.com/myce/welcome Once logged in, go to https://www.nestlemedicalhub.com/myce... 1) Enter PIN code: 69155258 in the box provided. 2) Select "Submit" 3) Complete the evaluation for this activity and select “Submit” 4) Select the Dietitian or Attendance certificate type in the drop-down box, enter your professional ID or registration number and click "Print Certificate." The certificate can be saved to your personal computer and/or printed. Juliet Richards 1.64K subscribers In this video, I explain what the mitochondria are, how they play a role in insulin resistance and what you can do to improve your mitochondrial function. See the full blog post here - https://www.thediabetesandhealthclini... OTHER VIDEOS YOU MIGHT LIKE: https://www.thediabetesandhealthclini... https://www.thediabetesandhealthclini... https://www.thediabetesandhealthclini... This is an educational channel for people wanting to learn more about diabetes and how to overcome it with Lifestyle Medicine and mindset. Juliet Richards is the founder of The Diabetes and Health Clinic and she is passionate about helping people to live happy, healthy and disease-free lives. She believes education is power and education plus action is a superpower. She shares her knowledge and expertise to empower people to make educated decisions that are in their best interest. FACEBOOK: https://facebook.com/julietrichards01 INSTAGRAM: https://www.instagram.com/the.diabete... TWITTER: https://twitter.com/Juliet_dhc LINKEDIN: https://.linkedin.com/in/julietrichards WEBSITE: https://thediabetesandhealthclinic.com THANK YOU FOR WATCHING, COMMENTING, SUBSCRIBING & LIKING. I would love to hear from you. If there is a topic you would like me to discuss or if you have any questions, please write this in the comment section below. Disclaimer: Juliet Richards does not diagnose, treat or prevent any medical conditions, but simply provides health information. All of the videos and comments are for educational purposes only. The information provided is not intended to provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. The information is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or another healthcare provider. Juliet Richards and The Diabetes and Health Clinic are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site. Disclaimer: This video and description may contain affiliate links, which means that if you click on one of the product links we receive a small commission at no cost to you. 72 Comments rongmaw lin Add a comment... Humpty Dumpty Humpty Dumpty 11 months ago (edited) Beautifully explained. Even a layman can understand. I am already working on reversing my prediabetic condition and this knowledge shall definitely help a lot. Thank you Juliet Richards. 3 Shaolin traditional medical Qigong & Meditation Shaolin traditional medical Qigong & Meditation 7 months ago Thanks Doctor. This is the most comprehensive lecture I hear on insulin resistance, cause and effect. 1 Juliet Richards Steve Y Steve Y 2 months ago Thank You so much, it's really helped me understand mitochondria health at the core level. Gonna avoid eating so much and processed carbs, didn't know they cause this much damage, and explains my tiredness. 2 Franz Büchel Franz Büchel 2 months ago (edited) Excellent explanation! - Supplementation for mitochondria would be interesting. 2 Health & Harmony Health & Harmony 1 year ago Thank you so much for this. The explanation was very clear, and the diagrams and writing were tidy. Thank you. 3 Alman Alman 11 months ago Thank you for an amazing most detailed scientific explanation to what a very abused subject 2 Martin Irving Martin Irving 1 year ago Interesting. I have a different interpretation of mitochondrial dysfunction. I see it as a gradual and increasing inability to oxidize fats for energy. The mitochondria become lazy and rely entirely on aerobic glycolysis (which takes less oxygen). Aerobic lipolysis takes more oxygen but ultimately provides more ATP with less CO2 as a byproduct. Yep, gotta keep those mitochondria happy, healthy and preferentially fat-burning. 3 Deep Dusto Deep Dusto 6 months ago Hi Julie, by far the best video. I love that you like connecting the dots, keeping an open mind - carbs vs fats and not being ideological. I do wish, if you could use the correct vocabulary alongside the beautiful simplification you do. I would like to congratulate you for having a clarity of mind that only few have, and I do wish that you can do a separate video (as I think you can do a wonderful job) doing a score-carding of ATP molecules generated with a combined picture of various pathways - Glycolysis, Pentose Phosphate, Heme synthesis, TCA, OxPhos. I so much wish someone can do that. I think such a scorecarding can be the most precious gem created. Juliet Richards Omar Toma Omar Toma 1 year ago Thank U for this Video I have type 1 DM and have noticed tow groups fighting about the cause and pathogenesis of IR One group is the KETO ( high fat ) and the the other is VEGAN ( low fat ) Believe me the answer is in the middle and with Fasting and exercise. BUT thanks again for showing the wholemark of the problem 1 PC Sim PC Sim 7 months ago Thanks so much for the very clear explanation. Really appeciate your work. Juliet Richards D D 1 year ago This is a great summary. 9 Mary Al-Humayani Mary Al-Humayani 1 year ago Thank you for your clear presentation. 2 Yasmin Larmond Yasmin Larmond 1 year ago Awesome presentation...very helpful 3 Fabienne Onyema Fabienne Onyema 4 weeks ago Thank you so much, I was really struggling to understand how they all interlink knight24474 knight24474 1 year ago (edited) 00:15:41 your problem 00:20:08 the solution 00:27:26 food to avoid at all cost 13 Steph Atherley Steph Atherley 1 year ago Excellent presentation. Will definitely try the program. What number do I call? In Florida. Lokesh Sharan Lokesh Sharan 1 year ago Helpful overview mam.. For starting my PhD in Diabetic neuropathy.. Thanks Nirmala Drieskens Nirmala Drieskens 7 months ago Great video ❤️❤️❤️ Juliet Richards Nelson Razo Nelson Razo 1 year ago Hi, Juliet. Nice work! You've got a mexican fan. I'm an applied nutritional sciences student trying to do exactly that: educate the population on the latest advances in chronic diseases reversal with lifestyle interventions. Javed Khan Javed Khan 1 month ago Omega 6 LA of process oil does most damage rather than saturated fat 1 Tackles Tackles 2 weeks ago What is the research data saying that saturated fat is bad? I've heard again and again that it's not bad at all. The Masai have a diet of primarily animal meat, with 50% of their calories coming from saturated fat, and they're just fine. Would welcome any technical explanation, including exact metabolic processes, to explain why saturated fat is bad. 1 Marc Vickers Marc Vickers 2 months ago What is the most ancient human diet? Ann Etcell-Ly Ann Etcell-Ly 1 month ago Good job! Pottenger's Human Pottenger's Human 1 year ago There's some good info but also some nonsense. Saturated fats go into the fat cells more easily but that is the correct path, otherwise it is likely doing something bad like becoming oxidized and going into the liver. Cows don't live in waste dumps and are not predators so biological accumulation is not an issue. The big pesticide and herbicide threats like roundup are also water soluble not fat soluble. The biggest problem with t2 diabetes is liver fat and the quickest way to get it is overeating carbs. 1 Explore_with_sagan Explore_with_sagan 4 months ago Avoiding environmental toxins: gadolinium injection gave me mitochondria dysfunction!! shelby chimamoto shelby chimamoto 5 days ago To get a better perspective, watch this presentation: https://www.youtube.com/watch?v=uIjzl5FQlK8 Jaroslav Víta Jaroslav Víta 9 months ago good work 1 gloria asaram gloria asaram 1 year ago Excellent 1 June sharp June sharp 7 months ago amazing Juliet Richards DrSource DrSource 11 months ago U say stay away from saturated fats but most people say MCT and coconut oil (saturated fat) is good fuel???? 1 whisperingsage whisperingsage 1 year ago Does she even know what causes mitochondria malfunction? Does anyone question the use of PROTON PUMP INHIBTORS? do we know that proton pumps are rich in mitochondria? Do we know that PPI's destroy the mitochondria in every cell? 2 Nalaka Prasanna Nalaka Prasanna 6 months ago Thanks a lot.... P.M. P.M. 1 month ago you get fat from meat and eggs? dont think thats true. 1 sonsofliberty sonsofliberty 7 months ago Noise of taking pen cap off and on is a little annoying. 1 California High Desert Preacher. California High Desert Preacher. 3 months ago It would seem everyone on the social media, only knows how to manage this disease. I am 5'9 tall I weigh 160 lbs in America. I have had diabetes for 10 I have come down from 180lbs. No matter what I have tried, I can not get ride of this disease. Medical Dr here have no answers . It makes me sick. butter pecan butter pecan 4 months ago (edited) Why does she pronounce the word insulin "inshulin"? Jay M Jay M 8 months ago Too many ads. whisperingsage whisperingsage 1 year ago I've never heard it called "inshulin" before. 2 Lynn Williams Lynn Williams 9 months ago Keeps saying inch cho lon? Do you hear that? But beyond that good info TheClassicalSymphony TheClassicalSymphony 9 months ago Annoying noises with her pens. Jared Rutter (U. Utah, HHMI) 1: Mitochondria: The Mysterious Cellular Parasite 115,185 viewsJan 7, 2020 iBiology 146K subscribers https://www.ibiology.org/cell-biology... Dr. Jared Rutter shares new insights into the interplay between mitochondria, metabolism, and cellular behavior. Mitochondria are integral to the metabolism of eukaryotic cells, yet many of their properties are not fully understood. In Part 1 of this iBioSeminar, Dr. Jared Rutter lays out the foundational knowledge of mitochondrial structure and origin, and shares what is currently known about mitochondrial roles in metabolism, protein homeostasis, and signaling. He ends by highlighting a focus of his research group: to unravel the functions of uncharacterized mitochondrial proteins. In Part 2 of his talk, Rutter describes his group’s work to unravel the relationship between the activity of the Mitochondrial Pyruvate Carrier (MPC) and the behavior of numerous cell types, including cancer and stem cells. His group found that forced expression of the MPC in multiple stem cell models led to reduced “stemness” and proliferative capacity, and that MPC inhibition could promote organoid formation in culture and tumor formation in vivo. These data indicate an important link between mitochondria, metabolism, and cell behavior. In his Part 3, Rutter emphasizes the challenge of mitochondrial protein synthesis. How do the components of the electron transport chain (ETC) assemble in the right stoichiometry at the right time? Rutter introduces the LYR family of proteins, which aid assembly of ETC components. LYR proteins interact with a common binding partner, the acyl carrier protein (ACP), via a unique fatty acyl moiety on ACP. Rutter’s group showed that ACP acylation is necessary for assembly of the ETC and activation of oxidative phosphorylation. Speaker Biography: Jared Rutter is a Professor of Biochemistry and holds the Dee Glen and Ida Smith Endowed Chair for Cancer Research at the University of Utah. Dr. Rutter received his PhD from the University of Texas Southwestern Medical Center in 2001, working with Dr. Steve McKnight. After receiving his PhD, he spent 18 months as the Sara and Frank McKnight Independent Fellow of Biochemistry before joining the faculty at the University of Utah. As of September 2015, Dr. Rutter is an Investigator of the Howard Hughes Medical Institute. In addition to leading his laboratory at the University of Utah, Dr. Rutter is also actively involved in translating these academic discoveries into therapies as a founder, consultant and board member of several companies and venture firms. Dr. Rutter also serves as co-Director of the Diabetes and Metabolism Center at the University of Utah and co-Leader of the Nuclear Control of Cell Growth and Differentiation at Huntsman Cancer Institute. https://rutter.biochem.utah.edu Chapters MITOCHONDRIA: THE MYSTERIOUS CELLULAR PARASITE 0:07 MY SCIENCE TRAJECTORY 0:32 MITOCHONDRIAL ORIGINS 3:10 MITOCHONDRIAL STRUCTURE 4:17 MITOCHONDRIAL PROTEINS ARE ENCODED BY TWO GENOMES 6:00 MITOCHONDRIAL METABOLISM 7:21 211 Comments rongmaw lin Add a comment... Anjum Madani Anjum Madani 2 years ago What a superb example of didactic clarity! Thank you so much Dr Rutter! 8 The Funky Bassist The Funky Bassist 2 years ago Thank you so much for such clear overview of the energy processes in the mitochondria. It's just baffling how complex the processes of our bodies are. Amazing also and looking forward to a lot of insight about energy restoration during burnout or chronic fatigue. 5 Ben Lee Ben Lee 1 year ago I really enjoy your mitochondria illustrated which help us understand the complicated biochemical reactions occurred in the mitochondria. 7 Michael B Michael B 2 years ago Thank you for sharing your hard earned knowledge! Fantastic overview. I can't wait to listen to the next two sessions. 26 Frank Biesta Frank Biesta 2 years ago Great explanation even for a lay person in terms of cell biology like me. Thanks! 9 Howard Petterson Howard Petterson 2 years ago (edited) I remember in 1977 when I first saw the mitochondria in high school and was fascinated and instinctively knew it was special We had to draw the cells in biology classes and I loved it. My most interesting one today is the telomeres and the progress of knowledge of how we age as the telomeres get shorter every time they duplicate 7 Ionut Gabriel Ionut Gabriel 2 years ago Thank you! Fantastic! As for mitochondrial communication and feedback loops I think bio photons should play a role. They are emitted in the process of cellular respiration, so it seems logical to play a role. I think that the energy of the photons might break some chemical bonds, so, if their energy is different various chemical reactions might be altered conducting the biochemical pathway to be different. 1 Bike Points Bike Points 2 years ago This is very nice and informative talk. Sir i have couple of questions regarding the ETS. My question is "how many numbers of electron transport system present in a single mitochondrion?". & next question is "how mitochondria sense about their homeostasis and decided to go for mitophagy." 2 Peter S Peter S 1 year ago Excellent presentation and excellent slides! Thank you! 3 Michael Shick Michael Shick 2 years ago Fascinating stuff; thanks for sharing it so broadly like this! 12 Tom C Tom C 1 year ago If a mitochondria was once a bacterium that was ingested by a eukaryote, can you speculate on the environment that it evolved in and the tolerances of that extracelular environment including chemical, thermal, Ph, biologic and electromagnetic? Also, how would their presence modify or contribute to that environment? 6 Paul Hirsh Paul Hirsh 1 year ago What a great teacher! Dean Mindock Dean Mindock 6 months ago It is great that all those functions going on within the cells are done without us having to be directly involved. :-) dezmoynes1 dezmoynes1 2 years ago (edited) Note: at 6:29 he references “animal cells”, but the point he’s making applies equally well to any eukaryotic cell which has maintained its mitochondria. 2 Thabet Muhsen Thabet Muhsen 2 years ago (edited) This is pure robotic work with clear programmed instructions to make this sophisticated factory of mechanical, chemical and electrical harmony, the more I learn about the cell, the more I want to meet the creator of these genius machines 1 Biology lover Biology lover 2 years ago Thank you i biology giving such type of lecture by great professor. 2 Chad Aitken Chad Aitken 2 years ago Thanks Dr J. What if the answer to either create ATP or Repair is if it’s creating enough/extra ATP? What about Ketones? Or nutrients needed to optimize the Mito. B Vits? Nad? Onto part 2. 👍 Roger Parker Roger Parker 2 years ago This is a brilliant lecture - so well put together. Thank you, Dr Rutter! 3 Alec Lynch Alec Lynch 1 year ago Fantastic video, thank you! One minor note, I think @15:144 he accidentally switched matrix and intramembrane space. You switched the audio, but not the captions. Would you mind editing the captions as well? Mrcl Ds Mrcl Ds 1 year ago Excellent. Thank you ! A question: the mitochondria came from outside the cell. How did it become part of cell replication? mwj5368 mwj5368 1 year ago Thank you Dr. Rutter for a very cogent and lucid video. I'm only a lay person and wondering about Omeprasol, a proton pump inhibitor, or "PPI" as medical people say. Can 11 years of taking Omeprasol cause ongoing problems with the Mitochondrion maybe not replicating as well? I had multitudes of cysts (benign) in my stomach. Two years ago cysts 2cm and larger were removed, many. My GI specialist at Mayo Clinic said he started seeing cases like mine once the "PPI's" came along. Being 66 yrs old, I take that into account, but every day there is a time where I have to take a nap or I'm very weak. I wonder if maybe my mitochondrion do not replicate as they use to and even though I'm off Omeprasol I have lower energy levels at times. Could that be true? 2 Jerry Bruton Jerry Bruton 9 months ago Thanks for the great lecture on the MItochondria 👁️IMOLDIN 👁️IMOLDIN 1 year ago We thank you I wish more would be like yourself. We will clone you you are valued! JOSHUA. Y. EL-BRUKEVWE JOSHUA. Y. EL-BRUKEVWE 2 years ago This is a great presentation and makes me understand what "Mitocods' are and how they work. I however wonder how this component of cell life and many other like it are as a result of evolution you are presenting them to us. Do you mean that the coding, programming, algorithm, precision and purposefulness, replicability displayed in these processes all happened by random chance. Do mean information processing procedure displayed in living cells all started by random chance and mutation. So information can emerge from the blues, coded and programmed and launched without designer and programmer? Please explain in a convincing way. 1 JOSE YANG JOSE YANG 1 year ago (edited) Hi, I’m a medical student and biology is one of our studies. There is one thing that is quite different to what we have learned from our biology professor and Campbell’s Biology ver. 11th. From 4:51 to 5:00 in this video, would you mind to provide any information or proof to show that the inner membrane of mitochondrial is indeed completely sealed and is impenetrable ? K Tyler K Tyler 2 years ago Before I watch these (I saw there are more videos about it) I have an idea, and please stop me if it’s stupid or wrong. Could this be used as a biodegradable alternative to lithium batteries? What I’m looking for, specifically is something that stays alive while charged, but breaks down in the absence of easily obtained conditions. If potatoes can power clocks, could this be artificially refined for more complex technology? FRED SMITH FRED SMITH 8 months ago (edited) How would the mitochondria do the 10 functions a cell must do: energy production, selective gateways, active transport, information processing, manufacturing, auto assembly, automated repair, sensors, signal processing algorithm, actuators, control systems, central coordination ! And how did the host cell produce energy before a mitochondria was present ? 1 Stefan Babel Stefan Babel 5 months ago Would it be possible to modify the mitochondira to accept electrons from a metal wire instead of using NADH ? This way all cell could be powered without nutrients but with pure electricity. Is there any research on that ? :) Just curious. Miguel Marina Miguel Marina 6 months ago wooow I am amazed of these results, we are basically made of microscopic machines, advanced nanotechnology, motors and even microscopic meshes!!!! also the way the DNA and RNA is composed, literarily it is programmed!!! and we are learning how to assemble these machines, design them and re-program them!!! 1 Anky Spon Anky Spon 5 months ago Mitochondria, living proof of intelligent design... Can someone explain how the original cell which ingested the mitochondria, was able to replicate another exact version of itself, that also included another mitochondrion inside! All cells have their own unique DNA which is the code needed to replicate 'perfect'' copies of themselves, usually via mitosis. The original cells DNA would not contain the complex genetic information needed to make a copy of a mitochondrion,,, so when the original cell replicated itself, the exact replica would not have contained any mitochondria! The cells in this video arrived in the fossil record as is, with the mitochondria present and the ability to replicate them, this can only mean that the cell had to 'spontaneously evolve' with the genetic code necessary for it to be able to replicate itself with mitochondria organelles inside. Evolutionists seem to be relying on miracles to perpetuate their 'theory'. Mitochondria defy all logic and could not have 'evolved'. Go to 17.30 in this video and look at the chart, then realise how utterly mind bogglingly complex all those chemical processes are. How can we be expected to believe that a mitochondrion simply 'evolved' the ability to carry out all those complex chemical processes, when it had no need to? Try replicating any of those processes from scratch in a lab and it would take decades to get the sequences right. Further more, none of those processes are needed for the mitochondria to survive on its own, nor do any of them offer an evolutionary 'advantages' to a mitochondria's survival (unless it is in a host). So why/how did the mitochondria 'evolve' to be able to produce ATP etc and what was the point? Only when a mitochondria is inside another living cell, do the chemical processes it is capable of performing become of any use, and even then, those processes are only useful to the symbiont, not the mitochondrion! People need to look past Darwin, they've been trying to make the theory work for a hundred years and cannot do so, intelligent design is the most plausible explanation, what are people afraid of. If you can conceive the possibility of a multiverse, intelligent design is much easier to believe. Most people commenting on here have no understanding of evolution beyond what they were taught in a few minutes of dinosaur lessons at kindergarten, this does not give them any ability to make informed decisions, or statements of fact about evolution whatsoever! You know nothing and are being mislead. True scientists need to have open minds, do the research, listen to Dr Steven Meyer or Gunter Bechly on here and you will see Darwins theory is still only that, just a theory, the very vaguest hypothesis that can easily be disproved by true scientists, it is certainly far from the truth! This entire video demonstrates one of the biggest failings of the so called 'theory' of evolution, as it totally overlooks the most crucial questions, how something as complex as a mitochondria could have possibly evolved in the first place from a few chemicals. The cell membrane itself is talked about as though it is a simple single layer of substance when even the simplest of membranes is a highly specialised structure, with multiple functions, such things cannot simply 'appear'. A mitochondrion is also far from a simple cell, it is a highly complex and specialised organelle, it did not and could not 'evolve' to be able to do all those chemical processes. According the fossil record mitochondria spontaneously appeared, with all the incredible biochemical abilities it is capable of, a miracle... Evolution is relying on miracles, it has to be, because it is cannot explain the complexities in design or function of even the most basic single cells or proteins. Proteins are not a few amino acids clumped together, they have design, and are highly complex machines that with specific functions and purposes! We still know nothing about evolution and scientists are not looking in the right place. Life had to have been created here on Earth, or it was seeded here from somewhere else, then the question has to be, how did it evolve in the very beginning. Intelligent design is the only logical explanation at the moment! This is clearly seen by the spontaneous appearance of mitochondria in the fossil record, an event that is even more significant than the spontaneous arrivals of other fully formed creatures, as seen in the Cambrian and other 5 similar explosions. 1 Nicholas Steel Nicholas Steel 2 years ago Wow ....the process of energy production is incredibly complex! 2 CrumbleLives CrumbleLives 2 years ago That's really interesting. Thank you! 2 Ice Ice 2 years ago Are there any vestigial metabolic processes from before mitochondria? 1 Stephen Hazel Stephen Hazel 2 years ago so a third of the proteins of mitochondria aren't understood? 1/3 of those used in the mitochondria or 1/3 of those created by the mitochondrial dna? and about how many is that in a (rough) count? pretty cool tho !! 3 Zakir Zak Zakir Zak 1 year ago Wow great presentation thank you 🙏 1 MrTridac MrTridac 2 years ago I'm fascinated by that stuff. And you've got some fine animations and graphics. Thanks for sharing. 1 Cell Creator Cell Creator 2 years ago a) How do we know that mitochondria started as engulfed bacteria? b) How do we know that mitochondria evolved? c) Mitochondria are very similar to bacteria. Is it true that modern medicine has crippled the life of thousands of people by administering multiple rounds of bactericidal antibiotics and causing permanent mitochondrial damage? Thank you. 2 Nicholas I Vanderstoop Nicholas I Vanderstoop 10 months ago Brilliant clarity even for a layperson like myself, I read the comments below , I agree with all. We are the Universe the same building blocks used incredibly creative. It leads to one thought, the incredible wonderful complexity is all involuntary, can you imagine if it was voluntary, us humans introducing democracy to the cells and give them choice. As in time we are absurd enough to introduce democracy to the Bee hive. Guaranteeing very little homey will ever be produced and honey will be become the new currency like bit coin for the super rich. This presentation teaches us understand it fix it if need be but leave by and large ‘ Well Enough ‘ alone. As species we underwrite our own epitaph. Mars here we come. Ted Phillips Ted Phillips 2 years ago Going from ADP to ATP requires the same energy as is released going from ATP to ADP. What is the mechanism that assembles ATP from ADP? What triggers ATP to release a "P" and become ADP? How does that released "P" do work ? Does it boing off a membrane and do mechanical work or does the release of the "P" create a local temperature hot enough to make steam which drives a mechanism? Is the activation energy going from ADP to ATP the same as going from ATP to ADP & "P"? what manages "P"? Is any electron/proton tunneling involved? The lecture represents countless hours of human effort. Yet without an explanation of the investigate techniques used to invent this model and verify its' correctness, one may as well memorize the phone book. How about a lecture demonstrating the techniques used to come up with and verify a model for just one step in the metabolic process? Pär Säthil Pär Säthil 2 years ago Starts at 02:48 james devine james devine 1 year ago excellent.....a wonderful machine that works on favors TheAlaskansandman TheAlaskansandman 2 years ago Maybe i missed something but could some one explain. What Nucleotides make up the double helix of MtDNA? Is it still ATCG? I know the double helix forms a circle but i cant seem to find info on what Nucleotides make it up. cahaya senja cahaya senja 1 year ago Thank you so much for sharing Peter Ginsburg Peter Ginsburg 7 months ago This is probably one of the most confusing presentations of how mitochondria work, that I've seen. When slides are jam packed with information and quickly presented with not much explanation, it just becomes gobbledygook. CYTOSESSIONS CYTOSESSIONS 1 year ago It's interesting i have heard the cytochromes are red light antennas used to create water? George Han George Han 2 years ago Easy stuff - only takes 10 years of biology training to understand. 7 You Are Beautiful You Are Beautiful 2 years ago I need a very detailed 3d presentation, with each actors involved pointed clearly out, to get something from this complicated functions. 1 Julia Julia 6 months ago Is the role of deuterium took into consideration in all of this? Sergio Viafara Sergio Viafara 9 months ago Mitochondria is awesome and the presenter either Carter Cole Carter Cole 2 years ago thank you great talk! J. Steven Carr J. Steven Carr 2 years ago I love the information! I have always suggested that all college professors take a course in public speaking. Dr. Utter is a fine man and researcher. His presentation skills are lacking. His use of the "uh" pause distracts from the presentation. Toastmasters teaches public speaking. TheOtiswood TheOtiswood 7 months ago I can appreciate your knowledge of biology. BUT how can you definitively say, " it's clear that mitochondria evolved..... " when you moments before said that we still have much to learn about the biology of mitochondria? I will have to say that The creation of life is better explained by The spoken word of The Lord creating it as The Bible tells us He did. 1 Angello Corriguez Angello Corriguez 1 year ago ¡SUPLICO LA TRADUCCIÓN AL ESPAÑOL...SOMOS MILLONES QUE NOS PERDEMOS DE ESTE CONOCIMIENTO! Glenn Davey Glenn Davey 2 years ago (edited) You gotta be the biggest Star Wars geek on the planet to make a 30-minute science video about The Force... Sukkulent Dad Sukkulent Dad 1 year ago great illustration! 1 Gary Ha Gary Ha 2 years ago "mitochondria are normally inherited exclusively from the mother; . ... The fact that mitochondrial DNA is maternally inherited enables genealogical researchers to trace maternal lineage far back in time.: 3 Maureen-Paul Barnes-von Kulmiz Maureen-Paul Barnes-von Kulmiz 2 years ago Given all this dazzling complexity, how do we experience life in such a smooth and seamless way. And just what are we anyway? 15 Glyn Williams Glyn Williams 11 months ago Very imformative Thank you for your ilucidation Martinz show Martinz show 1 year ago The question that boggles the mind of everybody in the know is I guess - what kind of an intelligence and how are those complexes, structures created. Not only what are the running processes, but who are the builders? Linda E Linda E 7 months ago Excellent! Yuling Li Yuling Li 2 years ago how important is NAD+ in this process? Stan Hopkins Stan Hopkins 2 years ago I understood every word to. It's the sentences that I need research further. Linda Foy Linda Foy 2 years ago Is there information on female inheritance of mitochondria ? SkeptiSchism SkeptiSchism 1 year ago It's really sad that this channel was forced to turn comments off on some other vids due to the religious fundamentalist fanatics that can't accept that their holy books creation story is pure myth. Truly sad. Great channel, and great insights into things I didn't really understand. I appreciate the work you guys put into this channel. Laura Wisniewski Laura Wisniewski 2 years ago Can doxycycline (taking it for one year) destroy mitochondria? 1 mafarmerga mafarmerga 2 years ago A good explanation of mitochondrial function but I was disappointed that you repeated the old Margulis model of mitochondrial origins. There never was a proto-eukaryote that ingested but did not digest an alpha-proteobacterium. Ask yourself these questions that I pose to my first year biology majors: 1) Why would a cell ingest but not digest a prey bacterium? 2) What was the original selective advantage that drove the symbiosis? It could not have been ATP production because no bacterium is known to pump ATP into its environment. Such a bacterium would be a dead bacterium. 3) How did an anaerobic proto-eukaryote ever come in contact with an aerobic bacterium? The presence of oxygen would have killed an anaerobic proto-eukaryote. Spend some time looking at the syntrophy hypothesis and other papers by Bill Martin and Nick Lane. 1 m7b5 m7b5 7 months ago Very interesting treatise. But what a pity that a bit of evolutionary storytelling has crept in again. 1 herauthon four herauthon four 2 years ago Are they all the same in all people - or are there tiny/large/specific differences ? Reality Reality 1 year ago Astonishing machines within us Ken Heart Ken Heart 2 years ago I understand every word! 1 Murray McEwan Murray McEwan 2 years ago Fascinating stuff, most of it way above my head. But I always find it grates on me when allusions are made to 'evolution' of the complex from the simple. In particular, adding comments about 'this or that evolved to become this or that', contributes ZERO to the revelation of the information, or the marvelous pathways that are unveiled by the meticulous research (which I marvel at). If biological evolutionary theory was worth squat, it would actually provide some kind of insight into why these super complex systems needed to evolve and make it easier to discern what is not yet known about various pathways. What was missing in those primitive organisms that we can now see why the new features evolved? Every organism that ever lived was of necessity, already capable of living, and therefore perfected already, and needed no improvement, by nature. We, as tinkerers can better forecast improvements while looking on from the outside, or at least think we can, because we have already compiled a tree of supposed relationship between all forms of life. Instead, the revelation of the information is immediately attributed as some sort of proof of evolution, which makes no more sense than me thinking that my Deja vu is already a Deja vu of another Deja vu. Deja vu explains nothing, it is just a silly notion that explains, forecasts and reveals nothing at all. The fact that very smart people have to labor long and hard to retrieve the information for these metabolic pathways makes unguided evolution absolutely ridiculous to contemplate. And if something guided evolution, then we need to know what that something is/was. Maybe. Or maybe we're looking so closely at the trees that we cannot see the forest. Watch some of James Tour's videos to get the gist. 5 Sergey Fox Sergey Fox 11 months ago (edited) Ok, this may seem utterly irrelevant, but... Why do these biological models look like factories? I am becoming better at understanding why these chemical, biological, and physical models in science feel and seem like frankly religious models of whatever science topic is spoken of. Why are science lecturers putting forth mechanical factory-like models of phenomenon they speak of? Hmm. Chasing a Murderer Chasing a Murderer 1 year ago Finally, an INTELLIGENT video William Domb William Domb 2 years ago How did cells possibly function BEFORE mitochondrial self-incorporated??? Ken Jackson Ken Jackson 2 years ago (edited) Fascinating stuff! I was pleased to learn Complex I has 7 proteins synthesized from mt DNA and 37 from nuclear DNA which all come together somehow in one fantastically complex machine. How could anyone think that this started out as a bacterium that became part of a larger organism's cell? The components are manufactured from distributed sources. It was clearly designed. 1 Cell Creator Cell Creator 2 years ago Does Dr. Jared Rutter answer any questions in his videos or is this a Sunday preaching? tarka38 tara tarka38 tara 2 years ago thank you so much Maria Orsic Maria Orsic 2 years ago (edited) Great summary, but not interesting depiction. If you want to understand how electron transfer moves protons, hire competent biophysicists. Why didn't you point out that the circular DNA structure is a plasmid? myutubechannel myutubechannel 2 years ago great, thanks Niall Browne Niall Browne 2 years ago I was quite looking forward to finding out more about mitochondria however this video veers off into the realms of supposition within the first few minutes. Evolution is not science. 1 Markus Lepistö Markus Lepistö 2 years ago According to my friends and relatives you cannot do anything "new" in science bec Einstein is the genius. Clifford Morris Clifford Morris 1 year ago Have you considered a quantum effect? John Fakes John Fakes 1 year ago 3:13 you know no such thing. This has yet to be demonstrated or observed, and it never will. But you state it as fact. 1 Valdagast Valdagast 8 months ago (edited) I'm sorry, but you can't have a video about mitochondria without mentioning the "powerplant of the cell". I'm sure that breaks some law. M E M E 2 years ago (edited) Fantastic ! Tks Bro ! andrew strasser andrew strasser 1 year ago When we are born where does the mitocôndrias come from? Is it already in the egg in the womb? Does sperm have any? ahmad attas ahmad attas 2 years ago Could any one plz answer me how to differentiate between insulin and ATP mechanism cause all of them can serve energy? penny coin penny coin 1 year ago Oke, why does my body feels suddenly like a universe itself.. or how should the body of the universe look like?? 0:) Much love from Sadé from the netherlands! 3 blk bbw blk bbw 2 years ago (edited) @29:18 Does the rest of the cells in our body also have unidentified proteins? pintopinnock pintopinnock 2 years ago Brilliant 1 TheOriginalMakaaka TheOriginalMakaaka 2 years ago (edited) 4:24 See that? That's what happens when you pull the zip up too fast and catch it. 4 Ronnie Wilson Ronnie Wilson 2 months ago If you believe that this evolved and wasn't created y'all aren't as smart as you think y'all are. I watch this and it complexity and see a designer hey I do thank you for your research and dedication we are fearfully and wonderfully made Deffo radio Deffo radio 4 months ago Epic! Sixing Hong Sixing Hong 1 year ago Fascinating Ronnie Cortex Ronnie Cortex 7 months ago 👍👍❤ Sid Michael Sid Michael 1 year ago Can a damaged mitochondria be restored? Martinz show Martinz show 1 year ago Every time there is talk about electron transport chain or electron carrying molecules - what don`t you use the language of generating electric current, and ATP - making batteries. hraqhraq hraqhraq 1 year ago 3:10 he says: "Quite clear that mitochondria evolved from aerobic bacteria entering cells" I don't know how was it clear and he never witnessed it or synthesized it in lab" also what a stupid bacteria it is aerobic and decides to go inside a cell which is anaerobic location to play and dance, I only would understand if it went to lungs or sinuses or nose and played there with oxygen it needs the most 1 JpDV96 JpDV96 2 years ago Handsomest teacher ever! sfamerken12 sfamerken12 2 years ago Misnomer in the title. It's more of a symbiote not a parasite. Address your error please. Aniket Tripathi Aniket Tripathi 2 years ago all natures evolution happen when species learn to live and benifits one another symboysis. Kris Oluich Kris Oluich 2 years ago My mitochondria are my life. 5 Martinz show Martinz show 1 year ago Elegant system - but who built it? 1 John Martinez John Martinez 2 years ago l want to marry a mitochondria! yohandsome yohandsome 1 year ago 15:25 ATP SYNTHASE GOES BRRRRRRRRR Martinz show Martinz show 1 year ago Why isn`t it told that every organelle has its own brain and consciousness ! Who is doing to the talking between the organelles. It is like an energy market. The talking is done by though! They are thinking! But no scientist is willing to say this. John Smith John Smith 2 years ago 15:25 WOOOOOOOOOOOOOOWWWWW!!! 19 Joe B Joe B 2 years ago Good overview but got motion sick watching Jared swaying back forth and back and forth and back and forth. Boris Petrov Boris Petrov 1 year ago (edited) Read any of Nick Lane books.... - especially The Vital Question and Power, Sex and Death Christianne DeMoro Christianne DeMoro 1 year ago HEY. THE LIFEVANTAGE COMPANY ALREADY DISCOVERED AND PROVED WHAT YOU AND COHBAR ARE TALKING ABOUT PROVING. LOL AND THEY HAVE PATENTS nurkle blurker nurkle blurker 1 year ago Could not stop thinking about how this guy looks like ryan reynolds a saal a saal 2 years ago powerhouse of my pelvis 1 RonJohn63 RonJohn63 2 years ago Dr Rutter, please work on not "tick-tocking" (shifting from one leg to another). Dima Fedch Dima Fedch 2 years ago True beauty of the most attractive organelle X X 1 year ago lesson: everything here is important and we're shit. Dino Miles Dino Miles 1 year ago Dr. Jack Kruse.. on you tube . 1 Stephen Gillie Stephen Gillie 2 years ago Slow video, takes over 30 minutes to provide the same rough, inspecific outline of mitochondrial operations, 3 times. This video almost has negative information density, even at 2x speed. Рамиль Татарин Рамиль Татарин 1 year ago 5+ Paulo Constantino Paulo Constantino 9 months ago Invaginated. LOL Steve Greenfield Steve Greenfield 2 years ago You keep on using that word; I don't think it means what you think it means. 2 Dr.Rose' Dr.Rose' 4 months ago Tnx Aaron R Lystila Aaron R Lystila 2 years ago love you utah History Keys History Keys 2 years ago "....really...really...really......." DoubleIrish DutchSandwich DoubleIrish DutchSandwich 2 years ago THE POWERHOUSE OF THE CELL 4 I am Groot I am Groot NIH VideoCast 33.8K subscribers Demystifying Medicine 2015 - Mitochondria: Biology Meets Disease Air date: Tuesday, March 10, 2015, 4:00:00 PM Category: Demystifying Medicine Runtime: 01:38:42 Description: The 2015 Demystifying Medicine Series, which is jointly sponsored by FAES and NIH, will begin January 6th and includes the presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, clinicians and program managers, the course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. All students, fellows and staff are welcome, as well. For more information go to http://demystifyingmedicine.od.nih.gov Author: Richard Youle, PhD, NINDS, NIH and Michael Sack, MD, PhD, NHLBI, NIH Permanent link: http://videocast.nih.gov/launch.asp?1... Mitochondria: dynamic organelles critical for human health 16,154 viewsOct 10, 2012 127 DISLIKE SHARE DOWNLOAD CLIP SAVE NIH VideoCast 33.8K subscribers Mitochondria: dynamic organelles critical for human health Air date: Wednesday, October 03, 2012, 3:00:00 PM Description: Mitochondria are dynamic organelles that fuse, divide, and move. Human genetic studies indicate that these processes are important for normal functioning of tissues, particularly neurons. Mutations in Mitofusion-2 (Mfn2) cause peripheral neuropathy (Charcot-Marie-Tooth 2A), and mutations in optic atrophy 1 (OPA1) cause eye disease (dominant optic atrophy). Mouse knockout studies focused on the mitofusins Mfn1 and Mfn2 have shown that mitochondrial fusion is important for organellar function. Dr. Chan will discuss mouse studies that reveal the physiological functions of mitochondrial dynamics. In addition, Dr. Chan will discuss how new mouse models can be combined with imaging approaches to understand the role of mitochondrial dynamics in neurodegeneration. The NIH Director's Wednesday Afternoon Lecture Series, colloquially known as WALS, is the highest-profile lecture program at the NIH. Lectures occur on most Wednesdays from September through June from 3:00 to 4:00 p.m. in Masur Auditorium, Building 10 on the NIH Bethesda campus. Each season includes some of the biggest names in biomedical and behavioral research. The goal of the WALS is to keep NIH researchers abreast of the latest and most important research in the Unites States and beyond. An added treat is the annual J. Edward Rall Cultural Lecture, which features top authors and other cultural icons. All speakers are nominated by the NIH community. For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series Author: David C. Chan, M.D., Ph.D., California Institute of Technology Runtime: 01:00:09 Permanent link: http://videocast.nih.gov/launch.asp?1... Chapters New aspects of mitochondrial dynamics 1:16 Mitochondria are dynamic organelles: Fusion and fission 5:58 Molecules necessary for mitochondrial fusion 6:51 Mitofusins and OPA1 act at distinct steps in mitochondrial fusion 8:25 Manipulation of mitochondrial morphology by control of fusion/lission ratios 9:45 Manipulation of mitochondrial morphology by control of fusionTission ratios 10:00 Mitochondria: dynamic organelles critical for human health 16,154 viewsOct 10, 2012 127 DISLIKE SHARE DOWNLOAD CLIP SAVE NIH VideoCast 33.8K subscribers Mitochondria: dynamic organelles critical for human health Air date: Wednesday, October 03, 2012, 3:00:00 PM Description: Mitochondria are dynamic organelles that fuse, divide, and move. Human genetic studies indicate that these processes are important for normal functioning of tissues, particularly neurons. Mutations in Mitofusion-2 (Mfn2) cause peripheral neuropathy (Charcot-Marie-Tooth 2A), and mutations in optic atrophy 1 (OPA1) cause eye disease (dominant optic atrophy). Mouse knockout studies focused on the mitofusins Mfn1 and Mfn2 have shown that mitochondrial fusion is important for organellar function. Dr. Chan will discuss mouse studies that reveal the physiological functions of mitochondrial dynamics. In addition, Dr. Chan will discuss how new mouse models can be combined with imaging approaches to understand the role of mitochondrial dynamics in neurodegeneration. The NIH Director's Wednesday Afternoon Lecture Series, colloquially known as WALS, is the highest-profile lecture program at the NIH. Lectures occur on most Wednesdays from September through June from 3:00 to 4:00 p.m. in Masur Auditorium, Building 10 on the NIH Bethesda campus. Each season includes some of the biggest names in biomedical and behavioral research. The goal of the WALS is to keep NIH researchers abreast of the latest and most important research in the Unites States and beyond. An added treat is the annual J. Edward Rall Cultural Lecture, which features top authors and other cultural icons. All speakers are nominated by the NIH community. For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series Author: David C. Chan, M.D., Ph.D., California Institute of Technology Runtime: 01:00:09 Permanent link: http://videocast.nih.gov/launch.asp?1... Chapters New aspects of mitochondrial dynamics 1:16 Mitochondria are dynamic organelles: Fusion and fission 5:58 Molecules necessary for mitochondrial fusion 6:51 Mitofusins and OPA1 act at distinct steps in mitochondrial fusion 8:25 Manipulation of mitochondrial morphology by control of fusion/lission ratios 9:45 Manipulation of mitochondrial morphology by control of fusionTission ratios 10:00 Comments are turned off. Learn more 10:22 / 13:27 The Role of Mitochondria in Aging and Disease - David Sinclair 225,558 viewsMar 6, 2014 5.1K DISLIKE SHARE DOWNLOAD CLIP SAVE Serious Science 89K subscribers Source - http://serious-science.org/videos/738 Harvard Prof. David Sinclair on alphaproteobacteria, reactive oxygen species, and why the nucleus and the mitochondrial genomes are like a married couple 468 Comments rongmaw lin Add a comment... hamed shahbazi hamed shahbazi 6 years ago Amazing work Dr. Sinclair! So impressed with not only your work but your ability to explain it!! 21 Carroll Hoagland Carroll Hoagland 5 years ago (edited) Thanks Dr. Sinclair .. a fan ... will be watching the outcome of your research ... since I am specializing in mitochondrial dysfunction pertaining to aging from a dietary approach, since as you know we have longevity mechanisms that repair all damage ... we just have to get out of there way and support our own metabolic processes as these bodily mechanisms are far more powerful than any supplement you can take ..., 70 Going On 100 … the Centenarian Diet … maybe 70 Going On 128 … the Hayflick Limit, or if a fan of Ray Kurzweil … then this is all a Moot Point. 18 Biophilia Biophilia 11 months ago (edited) Sir I have read Your book "Lifespan" on the same topic of aging - It was too informative ..I am Your big fan 😇..Loads of love from India. 7 ido shapira ido shapira 3 years ago Great lecture, sounds like the progression of insulin resistance. Thank you 8 Ben Nguyen Ben Nguyen 3 years ago (edited) What determines the actual number of mitochondria per cell? Is it tissue dependent or based dynamically on energy needs? Bruce Hay on the HumanOS podcast, mentions with respect to mitochondrial genomes, you have hundreds to thousands of them: "In every cell we have hundreds to thousands of these organelles floating in the cytoplasm. They’re always being generated, and they have their own genomes. It’s not just one genome for all mitochondria, but thousands." Does he mean that each mitochondria only has a portion of the mtDna? Isn't the mtdna so small (37 genes) that it barely codes for proteins anyways (13)? He goes on to say, that the "nuclear DNA is well positioned for repair, because we have two copies of all of our chromosomes. What that means is, that if the copy you inherited from your father is damaged in some way, the copy you have from your mother can actually act as a template for repair. In that way, through homology based repair, you can oftentimes reconstruct the information that was lost in the damaged strand." There was a good 'Ask Me Anything - with Spencer Wells and Razib Khan', but didn't cover basic questions like this. 3 William Tomkiel William Tomkiel 2 years ago so glad I found this . . Been on NAD, 100 mg. /day for almost 2 1/2 years along with Co-Q10, Carnitine and Creatine as also being mitochondrial supporters and at 72 function and perform as a man many years younger but it's also about sleep , stress, recovery protocols for the gym work-outs and so forth. 8 Raven’s Lair Raven’s Lair 3 years ago Excellent. A very well spoken Professor. I have so many questions! Would taking NADH assist in this regeneration?? 4 Benjamin Hardisty Benjamin Hardisty 7 years ago I'm actually an aging researcher myself. Trust me, the Sinclair lab is top notch. SENS is funding great work, but they're not bringing anything to market in the next 10-20 years is my guess. I don't even think the NAD treatments or protein chaperone treatments Sinclair's lab is studying will get anywhere for years either. Consider that mTOR suppressors can both raise and lower lifespan and we don't fully understand why and we've been using them for decades to get an idea of the technical challenges. My mTOR model is a 26 ODE system. My lab mates said, "Oh that's why no one's made a good mTOR dynamics model." 22 Winston Chang Winston Chang 2 years ago Very insightful, Doctor Sinclair. I can clearly see the worth of you living a longer life because you are an important part of human society with your intelligence and knowledge. You are our mitochondria. But , what do I do with a longer life or that of billions of people. ? .....?....Like , I do not want mice to live longer lives..... 6 Rock Forester Rock Forester 11 days ago So exciting! One can try a lot of this right now, and very safely. My goal is to live heathfully for however long I do live, and this research is exactly the ticket. Glenn Decker Glenn Decker 6 years ago Great ideas, but more basic science questions should be asked at the level of cell biology and ultrastructure. 4 Command Results Command Results 7 years ago Great talk theorizing the future of mitochondrial development as related to aging and longevity, 2 Alex Alex 2 years ago (edited) Wouldn't it be possible to look at the mitochondrial bacteria types which are living outside of human bodies, where they are less protected, to find some gens which could be used to make our Mitochondria more resilient to damage and mutations? 4 Vicente Sanchez Vicente Sanchez 2 years ago Excellent lesson and info. Thx 1 Serious Science Neville J Neville J 3 years ago I am nearly 65 and have found that taking a small amount of D-Ribose and some Creatine daily has given me a massive amount of energy and strength so much so that two or three days a week, I will run a 5K followed by an hour in the gym doing a heavy workout and then do about 3/4 hour of swimming and still feel like I could do more. I suspect am as fit as I was in my twenties. 14 Hobby Farmer Hobby Farmer 4 months ago Dr. Sinclair looks younger now (2022) than he did in 2014. That means his approach worked, i.e. diet, intermittent fasting, supplements, etc. 5 ZeraYaqob ZeraYaqob 2 years ago The human microbiome directs the communication between the cells and mitochondria as well as between other cells. One example is the role of menaquinone or vitamin K2, synthesized from vitamin K1 or phytonadione by certain bacteria in our gut, as a participant of the oxidative phosphorylation or electron transport chain (where 94% of cellular energy is produced) through its ability to accept and transfer electrons. 16 Halima Zamouche Halima Zamouche 2 years ago All your work is amazing! Wish you all the best! You only need to get this you can live healthier and maximise your body's performances but you will certainly die! Thats sad but it's a fact that we can't deny! Everybody dies and it's for a reson if people that lived before us didn't die we would be looking for another planet to live in! Even cells in our bodies die when other new ones appear! God bless you! 1 Pritam Borah Pritam Borah 7 years ago your analogy of the broken marriage of genomes was the best part.... 64 Baljit Singh Baljit Singh 11 months ago Very informative information 👍🙏 2 Nick Foxer Nick Foxer 2 years ago (edited) Great video, but he failed to mention the most important molecule responsible for mitochondrial function. OXYGEN..... Two words: Ozone Therapy. Learn as much as you can about it. In my opinion it's the single greatest practice we have for restoring health. I actually think the "secret molecule" that he's hinting at toward the end of the video (10:40) is Ozone. 4 Kevin Fairweather Kevin Fairweather 3 years ago Very succinct explanation ! 1 EK Lim EK Lim 3 years ago (edited) "Dear GP, how to make my heart age slower?" GP: "you should ask a cardiologist" "Dear cardiologist, how to make my intestine age slower?" Cardiologist: "you should ask a gastrologist" "Dear gastrologist, how to make my whole body age slower?" Gastrologist: "you should ask a GP" 17 thexeesus thexeesus 2 years ago Hm, his current 2019 theory describes aging in terms of epigenetic decline which seems quite different compared to mitochondria-nucleus interaction. Although in both cases decline in NAD plays role. Just questioning how reliable is all these. 4 Mark Sze Chai Chan Mark Sze Chai Chan 6 years ago Thanks it is fascinating! 7 saxmanchiro saxmanchiro 7 years ago It's a hypothesis, not a theory, yet. This reminds me of Dr. Dean Ornish's idea, back in the mid 80s, of reversing heart disease with diet only, quickly. Many in the medical field scoffed at him and chastised him for his foolishness. Now we know the truth. He was right. Sometimes, a crazy idea in science gets ridiculed until the irrefutable evidence comes in. Could be a game changer for sure. 54 Chris McAulay Chris McAulay 7 years ago Incredible - now I just need to find a reason to live - lol 255 GrooveDoctor77 GrooveDoctor77 7 years ago I have tried Niagen about a week ago , Im still sceptical but, I have(had ) 3 loose teeth , but just yesterday I noticed 2 of those teeth have tightened by a large degree , the 3rd tooth is still loose but even that tooth has tightened ..so after week I have hopes that this product is working,(re edit (3/2015) after 2 months of Niagen...I am completely amazed at how well this works, I could list 7 or 8 improvements all over my body ...the most recent amazing thing is..I have been diagnosed diabetic for 5 years, I still eat the same ,.. but I have had to reduce my med intake (I probably will quit Glyburide soon) because my glucose levels were dropping to normal by themselves , I lost 8 lbs of fluid retention after the 2nd week... I am 165 lbs from 173, never realized the bloating in my face & body until I looked at a video from Nov 2014 & compared it to a video I made a couple of weeks ago..1 thing I can say...thanks Dr, Sinclair 12 Tomas Hull Tomas Hull 1 year ago Aging can't be stopped... Everybody dies... Some signs of aging could be slowed down and reversed... temporarily... The cell division processes breaks down eventually... the telomeres get shorter each time it happens... mutation load in increases with age... It's all driven by quantum mechanics... 3 pikiwiki pikiwiki 2 years ago I understood everything! 5 PROCESSOR302 PROCESSOR302 7 years ago You still have to stop cells going into senescence after repeated cellular replication. One way of doing this is to maintain telomere length. 21 Srtj.Av. Srtj.Av. 2 months ago I love when he smiles as is a good thing happening! 😊 IW Nunn IW Nunn 2 years ago I don't want to live forever. I just want to be healthy and live an optimum life while I'm in this body. 61 bcbr bcbr 6 years ago But why do the nuclear and mitochondrial genomes stop communicating in the first place? What causes the nucleus to think that it isn't receiving enough energy? 7 spruceguitar spruceguitar 1 year ago "I do not want to live forever in the memory of the people. I want to live forever in my apartment." Woody Allan 8 Blue Jay Blue Jay 2 years ago (edited) what's calcitrol? i saw it in the the Closed Captioning. Mitochondrial Autophagy is caused by Parkin-pink1. Parkin-Pink1 attaches to a receptor on the outter mitochondria membrane. there's 2 types of autophagy. Selective Autophagy from pomegranate's elligic acid and a specific probiotic trigger selective autophagy and universal autophagy from Intermintent fasting. Autophagy is when a damaged mitochondria gets enveloped by a membrane with a libosome. And breaks the mitochondrion into amino acids. to be recycled back into the cell. selective autophagy is the type triggered by high ROS from damaged mitochondria.universal autphagy just autphagies them all, except the Mitochondria. beacause the mutant mitochondria don't.produce ATP. So no ROS by product. to help facilitate the bond of Parkin-Pink1 to the autophagy receptor on the outter membrane. i know South Korea has developed a healthy mitochondria injection method. and England has their mitochondrial donor program for three parent babies. Is there a connection between mitochondrial fuction and telomere? i wonder. 1 joe schmo joe schmo 5 years ago The body likes to have a 700:1 ratio of NAD to NADH according to a video by Shallenberger. That shows how important NAD is. 2 Kay Halsey Kay Halsey 3 years ago Thank you for the information. 2 Sun Sun 3 years ago sleep, nutrition, movement, absence of stress, good emotions +++ 39 David Maletich David Maletich 6 years ago NAD levels can be raised naturally through caloric restriction and/or periods of intense exercise. Either of these separately or in combination create periods of negative energy balance within the body which raises NAD levels. There are some supplement companies out there such as Life Extension who market nicotine riboside as an NAD enhancer. I wonder how safe this would be for someone to take who is already engaging intermittent fasting/caloric restriction and/or a fairly demanding daily exercise regimen? 36 JAMES B. JAMES B. 8 years ago The first NAD+ supplement was just introduced by the same company that developed both the first high potency Resveratrol and Pterostilbene supplements, Biotivia LLC. It is by no means cheap but if it were it would probably not be genuine. The name of the supplement, which is extremely limited at this point in time, is Mitotrans. 2 Tenerezza jie Tenerezza jie 5 years ago (edited) I have a question.... If communication is so important, why didn't the communication evolve to become more "direct" physically instead of relying on shuttling proteins? Gerald's Videos Gerald's Videos 2 years ago Thanks for this. Reduce inflammation! 2 tigerkills tigerkills 2 years ago Every medical professionals should learn this. Sarge Sarge 2 years ago Isn't there a basic fallacy at work here... if we just learn enough about the tiny details of human health eventually some magic pill or molecule will emerge to fix everything? 3 Graeme Gladman Graeme Gladman 2 months ago You need to research vit K2 or and L - Citruline for its anti aging effects. It has wiped my wrinkles and made me years younger. I don't know which one is responsible or it could be a combination of the both. Watta Watta 7 months ago some free radicals are good for the body thats probably why u dont wanna remove all of them, but if they do damage dna then maybe thats something to look into فدان فكرت احمد فدان فكرت احمد 5 years ago Thanks it is fascinating 2 you r enough 💜 you r enough 💜 4 months ago Intermittent fasting can and will repair your midocondria and clean keto 🥰 1 Pamela RedPill Pamela RedPill 3 years ago Love it if we had a real treatment for mitochondrial disease... 3 Hank Nelson Hank Nelson 2 years ago Something much, much bigger is needed, to absolutely be born again. This is a concept that goes beyond the real date of the pyramids. A perfect human is what may very well be locked away in our genes. But first we need to believe that he is there. Hainet Korea Corporation Hainet Korea Corporation 1 year ago Marine algae.Green seaweed(Chlorophyta) Ulva prolifera is a species of seaweed in the family Ulvaceae that can be found worldwide. Ulva lactuca(linza, pertusa, rigida) etc The pigment comparison of photosynthetic plants and green seaweed. The nine pigments based on chlorophyll in green seaweed are the same as plants. What is the structural color of green seaweed ? It is the color that appeared in the natural physiological and ecological environment when photosynthesis in the earth's environment. Nine Colors:Green,Yellow,White,Pink,Red,red-Purple,(reddish Brown-Brown),Blue,Black. The changes in the color of green seaweed are intended to communication with each other due to environmental conditions.(transformation of chromaticity and breeding of offspring) Who are the ancestor of life on earth ? Genetic and evolution of Earth life.(Eukaryotes: Mitochondria) Mitochondria are Alive:Dried, Bleached, Melted, Rotted(Black) mt DNA: Genetically, it has pigments information and Produces photosynthetic pigments. mt DNA: Nine genetic pigments(Rainbow colors and white, black) Nine melanin pigments(Skin, Eyes, Hair):Human, Marine and Land animals kittyhooch1 kittyhooch1 2 years ago After this watch a recent video of him. Six years later he is visibly younger. 17 Benjamin Hardisty Benjamin Hardisty 7 years ago I do think, however, that there is way too much salesmanship in the aging field in general! That def. perturbs me. 10 Term limits Com Term limits Com 2 years ago (edited) Notice his eyes.... no jaundice like 75% of other people. Also look at his knuckles no edema no tremors and no mandibular deformation from poor dental health..... I trust him. Did you know he wrote a book on this in 2019? 1 Manuel Ojeda Manuel Ojeda 1 month ago I just turned 70 and I feel great. 1 Abraham Robles Abraham Robles 2 years ago The mitochondria is the powerhouse of the cell :) 16 Splassshhh1234 Splassshhh1234 1 year ago I like the joy he has 2 Niagen Longevity Booster Niagen Longevity Booster 6 years ago Does it work or not? Nanoscience and cell sciences are booming now. In Boston alone the patent list is growing for new compounds and discoveries. This field is only going to grow. I see it everyday in New England. If you like drug stocks that come from new sciences look at Boston. (Home of Harvard and MIT) One thing I can say for sure is it helps me. 2 Shapan L Shapan L 2 years ago Interesting topic Doctor but it's very theoretical and still no technique or medicine or diet strictly to improve mitochondria function is available. One thing which I never understood about is free radical? According to biochemistry free radical is the driving force to all the enzymes in body to hasten the function so as to remove the free radical itself so in this process the function of the enzymes is constantly active not in silent mode so what if there were no free radical at all in carbohydrate or protein or fat metabolism ,won't the enzymes go in silent mode and since no activity would lead to death. Our body needs stress to stimulate and relaxation to calm down so that's why sympathetic n parasympathetic are created .... So please do make me understand about free radicals Doctor Thankyou 2 Tom Provan Tom Provan 3 years ago 2014 pretty old news has anyone an update? It is possible now to get all the supplements to keep the krebs cycle humming and the ETC working including adjusting the nad+/nadh ratio. I am sure lots f people have tried it. It would be interesting if they would post there results. Although the only test might be still healthy at an advancing age? Chad H Chad H 3 years ago There are a couple of unsettling things about this video "When we let mitochindria into our cells..." (as if we didn't enslave this species) "Except in my germ cells... in my testes..." [maintains eye contact] 3 Robert Robert 1 year ago Nice analogy, the mitochondria are all maternal. Perhaps they can be put in an hibernation state.. For space travel! Grace 2U Grace 2U 3 years ago what about the supplement Ubiquinol( Co enzyme Q10) this is supposed to raise atp production? 2 Yuan Yao Yuan Yao 3 months ago He definitely looks younger now, wow 1 Levizja per dije Levizja per dije 2 years ago Lelouch: Suzaku live. Suzak: Should i take NMN, Metformin and resveratrol like Sinclair. Code Geass 4 Splassshhh1234 Splassshhh1234 1 year ago INCREDIBLE 1 C B C B 3 months ago Where did alpha proteobacteria (precursor to mitochondria) come from, and how did they become part of us? How did humans create energy before this happened? Hank Nelson Hank Nelson 2 years ago The price for The NAD Treatment Center Detox Method can range between $6,000 to $17,000, depending on the specific program that is recommended for you and discussed with NAD Treatment Center staff. For reference, a typical 10-day treatment is $11,850. 2 Secret Soul Secret Soul 1 year ago (edited) We dont need to live forever, if we do, we are having lot of problems in coming. Plus we are not dying just bcoz of aging... Pandemic, accidents n killed... We not study aging to live forever Prof, but why aging science is important, its because aging related to many diseases. With our modern unhealthy living styles, we only look for remedies of the damages we have done. Study ageing is my favorite stuff but to live forever... Thats on diff page😂 Brendle Lau Brendle Lau 1 month ago So if i have less functionality of mitochondrial DNA or i dont make enough of it when young i would die of a lack of cells with enough energy to run a marathon, when i am older, i am so glad it will happen later than earlier in life, but when is the cut off point when mitochondrial DNA start to grow less useful Delia Ocampo Delia Ocampo 2 years ago No worries being serene contented in life eating healthy and financially sound the secret of looking young longer life 🇸🇽🇺🇸 Green Wealth Green Wealth 2 months ago Thank you very much. Kyle A Kyle A 5 years ago is it bioavailable orally? does it only restore muscles to a youthful state or all cells and that is just the example he used towards the end of the video? Jivoy Jivoy 8 years ago Very interesting 5 Ziya Onbashi Ziya Onbashi 6 months ago Sinclair looks younger now that he is 50 3 RedEyeification RedEyeification 2 years ago "You'll find the Truth and the Truth will make you free"...Jesus Christ VEE VEE 3 months ago I volunteer for that aging research!! Nicoleen Wentzel Nicoleen Wentzel 2 years ago I am 59 years old. My husband is 64. I feel like I am getting younger. I have lots of energy and are able to do 12 hours hard labor. My husband looks like a really really old man. I often wondered if I am too young for him or if he is too old for me. My whole life I had the idea that I am slow. It is strange and I could never really understand why I am years behind other people. I do catch up eventually but then they are old and I feel young. Today something just popped up in my brain: Micro Con dial. I had no idea what it is, so I googled and find this video by David Sinclair. Does this make any sens? 2 Khamis Zananiri Khamis Zananiri 4 years ago excellent.thanks 1 Andrew J Andrew J 3 years ago And they say Glyphosate is perfectly fine because it only affects a metabolic pathway of bacteria. mårten Sundling mårten Sundling 1 month ago His own appearance has also changed quite drastically if you look at him today, i swear, his five years younger today, five years later, so his own concoctions seems to work.. Delia Ocampo Delia Ocampo 2 years ago Mr.Sinclair only 50yrs.old just look his age no artificial and in the genes too looking younger 🇸🇽🇺🇸 Samuel Lopes Samuel Lopes 4 years ago I wonder if Antibiotics have a direct impact on mitochondrial dna? 2 David Cardano David Cardano 2 years ago If we are not living longer than we were ten thousand years ago then why was the life expectancy around 30 years in the 14th century? Alfred Hitchcock Alfred Hitchcock 2 months ago We live forever in heaven Zach Sicurelli Zach Sicurelli 11 months ago He looks the same age today. His regimen seems to be working a bit... 2 juntjoo nunya juntjoo nunya 3 years ago So where do you find this magical "NAD" in nature? Please say donuts 70 Emily Ingrid Laura Emily Ingrid Laura 3 years ago He sadly takes metformin instead of just addressing insulin resistance with intermittent fasting and Keto. 2 Lahzy Lahzy 2 years ago This is almost 6 years ago and he looks younger now... 43 Jonathan Hadley Jonathan Hadley 2 years ago What if the Mitochondria is damaged through Toxin exposure?! 2 Fatma Almarashi Fatma Almarashi 2 years ago I love anti aging science I am Amercan Board certified Endocrinlogist could you give some trading in this new science or rather do you offer fellowship in antiaging? 1 Explore_with_sagan Explore_with_sagan 4 months ago (edited) I got mitochondria dysfunction at age 27 through gadolinium injection. Can't function without coq10. Still too weak Chris T Chris T 2 years ago He claims he is 40 in this 2014 video... but i think he says he is 50, in a 2019 video? I believe his hair also looks thicker in recent videos, but face and brow may be less expressive like from botox or something. That, or he is successfully reversing aging on himself. 1 La Charmer La Charmer 1 month ago This video is from 2014, we have come a long way since then. Cocoa Cocoa 1 year ago why would you want to live longer than your species is supposed to? being alive is hard and moving on is important. 1 JC JC 1 year ago I thought this video was made in 2021, because he looks exactly the same today. Something's working. 1 IW Nunn IW Nunn 2 years ago An argument against monogamy!! 5 Shine Bright07 Shine Bright07 2 years ago Cyanide is in many Fruits....and B12, cyanoCobalamin, type of B12. 1 Ati Movers Ati Movers 2 years ago Creatine supplements can increase atp production. Any correlation to this topic? 3 Reed Wells Reed Wells 1 month ago If We Are A Combination Of 2 Species, Human Being 1, What Is The Other? joe schmo joe schmo 5 years ago Evidently Frank Shallenberger has known about this for a while, I think before 2013. 1 Samuel Lopes Samuel Lopes 4 years ago Ketosis increases NAD+ to fight off inflammation 7 F1Partisan F1Partisan 2 years ago reverse aging? that is like a child asking to eat candy forever! you can eat right and live well. If today was not enough then 2 hundred years will not . 1 Elizabeth John Elizabeth John 5 months ago Amazing E M E M 2 years ago note how this is from 6 yrs ago and david sinclair has not aged one bit... 1 DR Gunjan chaudhary DR Gunjan chaudhary 3 months ago And I did that 😊🙏❤️ spicaofla spicaofla 1 year ago mitoQ is the miracle supplement Arunava chakraborty Arunava chakraborty 3 years ago Who is making mitochondrion old.. probably some chemical ..and that chemical problem created by dna...that dna tell the chemical function to make mitochondria old so we have to find that dna who made the chemical function and made us old....simple and easy answer do study in dna...dna is making us old .....if I had money to study in aging..I would have cure aging ..fuk economy ..just because of economy i can't do study and helping human ..and cure my own aging.. 2 Rusty Cottrell Rusty Cottrell 2 years ago thanks for caring and sharing Gordon Seay Gordon Seay 2 years ago You don't hear the interviewer. Did they simply ask "hey, David, how are you?" and then he spoke for 13 straight minutes? :) 3 Zbigniew Brzezinski Zbigniew Brzezinski 8 days ago His projection didn’t materialize so far! Jane Roth Jane Roth 2 years ago Does NAD help people with MS? Vincent Napolitano Vincent Napolitano 5 years ago can intermittent fasting help repair our cells? 4 Fit Pro Fit Pro 2 years ago (edited) We need coq10 to make energy in the midcandria. 2 Li Li Li Li 4 years ago The best way in practice is still dietary restriction. 2 CKJ CKJ 2 years ago Today it’s known as stem cell therapy. Problem is the “gold standard” clinic is in Panama with Dr Riordan. And it’s expensive. Khaldoon Aljerian Khaldoon Aljerian 1 year ago (edited) 0:55 "Not living much more than 10K years ago"....Bruh... we more than doubled our age! https://youtu.be/v3ncUYKme4k?t=55 Lorenzo Northern Lorenzo Northern 4 years ago This is 4 years ago. How it went with humans? 16 Zerry Lo Zerry Lo 5 days ago Red light LED come to the rescue. It cure my hepatitis B & C, allergy skin problem, nasal problem. Mark Hedger Mark Hedger 2 years ago Reset mitochondrial function with sunrise and sunset bathing , Dr Jack Kruse 1 Glenn Decker Glenn Decker 6 years ago Many relevant experiments can be, and should be, using immunoelectron microscopy. I can help, if only through sharing my experience and ideas... Jason Bulsa Jason Bulsa 3 years ago Biochemistrical signaling. There are the preassembled supplies you need; make more NAD+ 1 Manuel Ojeda Manuel Ojeda 1 month ago I still teach piano 🎹 in a Music 🎼 Institute 37 miles from where I live. I don't take any Medication at all. Alex Menz Alex Menz 3 years ago What if we raise those nad levels in young people? 2 Manuel Ojeda Manuel Ojeda 1 month ago My neighbor's Mom is 80 years old, and she milks cows, was riding a horse daily in Mexico, she doesn't ride the horse anymore. She is strong as an Ox. tigerkills tigerkills 1 year ago L Dopa is converted to Dopaquinone and then to melanin by an Enzyme tyrosinase I think Vit k2 has something to do with it?. RAS in short RAS in short 5 years ago great S.L.S S.L.S 2 years ago I'm 73 yrs old, so I guess i'm screwed. That's ok 'cause I plan on living 'til I'm 107. 2 dee js dee js 1 year ago Eat mushrooms it feeds our mitochondria!! Salve regina 1 Rashid Ahmad Rashid Ahmad 2 years ago NMN cause elevated homocysteine. Please advise Gerson Freire de Amorim Filho Gerson Freire de Amorim Filho 2 years ago Great 1 Gio Sarran Gio Sarran 2 years ago Wow! mary ann carrlton mary ann carrlton 3 years ago Hence the mitochondria aren’t happy for many. 1 Bryan Sarver Bryan Sarver 3 years ago Ok what’s up with this niacinamide and nicotinamide are they the same? Please explain anyone Sherry Clement Sherry Clement 11 days ago When the test on humans? Maybe help delay some diseases? Rod Inz Rod Inz 4 years ago NAD+ !! 1 George Stephenson George Stephenson 1 year ago I really enjoyed your video. 8have life extension instruments edstud1 edstud1 4 years ago Sounds like marriage counseling for the cells? 3 Fon D Fon D 1 year ago Exactly Sid Michael Sid Michael 2 years ago NAD OR NMN OR RESERVATROL?