Salk Institute: The “Age” of Mitochondria 7,597 views Feb 18, 2020

Gerald S. Shadel Talk title: The “Age” of Mitochondria 7,597 viewsFeb 18, 2020 Salk Institute 9.86K subscribers Back to Basics Lecture series at the Salk Institute with Salk Professor, Gerald Shadel. Shadel is a professor in the Molecular and Cell Biology Laboratory and holds the Audrey Geisel Chair in Biomedical Science. The talk title: The “Age” of Mitochondria 29 Comments rongmaw lin Add a comment... Dennis Cerletti Dennis Cerletti 5 months ago Seed oils damage mitochondria.A 2002 study from Italian scientist measured the energy generated from mitochondria from4 fatty acids.Saturated animal fat produced 100% and was given the baseline.Mono-saturated fat was 115% is was surmised that it's molecule structure was such that the opening was in the middle of the molecule and was a easy snip to have 2 shorter stable saturated fats.Linoleic Acid/ Omega 6, the most abundant in seed oils, polyunsaturated fat, only produced 50% energy and Linolenic Acid/ Omega 3 only produced 20% energy.Study is sighted in Dr Cate Shanahan's book," The Fatburn Fix" also view Dr Chris Knobbe YouTube videos for further understanding of the negative health effects of seed oils. 5 dominic toretto dominic toretto 2 years ago i am a big fan from the big range of fantastic research the great salk institute do. greetings from germany Life is short, don’t waste time. The actual talk starts at minute 12:45, but doesn’t actually get going until much later, so buyer beware. I wish there wasn’t as much time wasted in all these yt videos - please do a favor to all viewers and always indicate in the comments when the ACTUAL CONTENT YOU CAME FOR starts, it would be much appreciated! A Mitochondrial Etiology of Common Complex Diseases 49,705 viewsMay 23, 2017 930 DISLIKE SHARE DOWNLOAD CLIP SAVE UCLA CTSI 1.62K subscribers Douglas C. Wallace, Ph.D. Director, Center for Mitochondrial and Epigenomic Medicine (CMEM) Professor, Department of Pathology & Laboratory Medicine The Children's Hospital of Philadelphia 56 Comments rongmaw lin Add a comment... ruthheasman ruthheasman 2 years ago Fascinating talk. Please read Mae-Wan Ho who asserts that the body’s connective tissues and cells are attuned to each other in a quantum coherent field such that they form a liquid crystalline matrix which gives a rainbow effect under a polarising microscope. “The rainbow in the worm means that organisms are liquid crystalline and coherent to a high degree, even quantum coherent. This means that the entire organism is electrically polarized from head to tail, like a single uni-axial crystal. Not only are the macromolecules in all the tissues and cells perfectly aligned, but also the 80% by weight of water. Actually, it is the water that makes the entire organism liquid crystalline because this water is liquid crystalline, in the sense that the indi-vidual molecules are ordered and electrically aligned, much more so than in bulk water. Above all, in order to see the rainbow colors in the living organism, the liquid crystalline molecules not only have to be aligned, but also moving coherently, macromolecules and water molecules together. Because coherent molecular motions are much slower than vis-ible light vibrations, the ordered alignment of molecules will still be registered by the light passing through.” https://www.academia.edu/5706255/Superconducting_liquid_crystalline_meridians 16 Ben Nguyen Ben Nguyen 3 years ago Great lecture! Enjoyed the part on the differences between mendelian/anatomical diseases and mitochondrial/energy diseases! Regarding the 8m mark, if 30% of the weight in humans is mitochondria (10^17 cells), that each have this electrical potential capacitor-like function.. any thoughts if exposure to external Light/PEMF can be beneficial/harmful? For example, isn't near infrared-light absorbed in the mitochondria by the Complex IV enzyme, leading to faster wound healing? What about magnet rings or magnetic mattress pads? I get how a prolonged loss of Complex 1 function can gives rise to Parkinson's.. either through the decrease of ATP or the increase in metabolites (L-2GH, etc).. but why is it that a minor inhibition (Class A or Class B) of Complex I also appears to provide positive benefit?! For example, Metformin, a weak C1 inhibitor, seems to engage AMPK/autophagy, with signs of anti-aging, anti-diabetic, anti-cancer, and anti-inflammatory! Is it possible that the correlation between aging and the reduced mitrochondrial capacity (assuming the relationship is causal) is an adaptive response, not mal-adaptive, and attempts to increase output via intravenous NADH+ are not ideal? A better approach may be to slightly lower mitochondria output, such that it lowers the ROS (H202)/inflammation signaling and increases the 'low-resources' signaling? 57m Regarding the 15m mark on why mitophagy and the 13 peptides used in C1-C4 are all encoded in the mitochondria (ex. PINK1 /PARKIN , Cytochrome C)... given nuclear dna has many more protective mechanisms (nucleosomal histone proteins, etc), coupled with the constantly replicating colony of bacteria/mitochondria within a cell, this seems more error-prone since any mitochondrial dysfunction to the mitophagy mechanism (caused by pollution, Rotenone pesticides, etc) would go unchecked and accumulate leading to aging/pathology, no? Regarding the 35m mark, I've heard David Reich and Spencer Wells talk about work on mapping the human origin/migration/Phylogenetics.. did Wallace work with Reich/Wells? I also recommend Doug's interview on the IHMC Stem Talk Podcast (14m, 47m, 58m. 1h23m)! 6 Martin Irving Martin Irving 4 years ago (edited) In fact, according to Wallace, it's the Mendelian theory of genetic traits being passed down that continues to be hammered into medical students at the standard medical schools. I'm not too sure standard Darwinism, let alone Endosymbiotic Theory is in the regular medical curriculum. Hopefully that will be changing. 7 Luis Gerardo Llamas Gutiérrez Luis Gerardo Llamas Gutiérrez 9 months ago I used to concentrate at night and see these sparkling specks of light wiggling at me they would be red and blue for me and that would help me fall asleep as a kid. Now you mention it like that has me wondering a lot. Because 20 years later into my twenties I spotted those again in the preceding moments of a peyote trip. The specks turned into a spiraling ladder much like the so called DNA 🧬 and I feel I went down on it, or into it... Was pretty crazy from there on. 2 Martin Irving Martin Irving 4 years ago (edited) I agree, Jack Kruse, that the Darwinian concept of evolution, particularly as conceived in the mainstream, the establishment, and the patriarchy, is characterized as a genetic arms race. This idea has won the day and has influenced (controlled) the direction of medical research, much to the detriment of human patients. It was about the magic bullet and the pot of gold at the end of the rainbow. This idea worked for infectious disease and the same approach has been used for metabolic disease (including cancer) with dismal results for patients and outstanding results for industry. Sequencing the human genome helped researchers, and the establishment, realize that genetics was not so significant and it is about epigenetics and the health of the microbiome. There is a better concept of Darwinian evolution that remains suppressed from the mainstream: sybiogenesis or endosymbiosis. Bacteria, which dominate the planet have helped multicelled organisms along the way in a symbiotic relationship. Mitochondria were a bacteria that figured out how to process oxygen and formed a relationship with multicelled organisms. Without bacteria, there would be no, so called, macro evolution. Then we get into the special requirements of particular species. It is the gut bacteria that allows a giraffe to eat acacia leaves exclusively, or a koala to eat eucalyptus leaves exclusively, or a panda to eat bamboo leaves exclusively. These animals, in the wild, eat only one thing and it is up to the microbiota to generate the essential nutrients the animal needs. I won't get into the special requirements of the human species other than to say we do appear to have one, and it is unique to our species and determined by our evolutionary history and the origin of bipedal apes. 13 Immortality Immortality 5 days ago (edited) Awesome presentation. The problem is... does fixing the mutation make the disease go away? CarolAnne Feehan CarolAnne Feehan 5 days ago Such a wonderful talk. Thank you for sharing. Bungifun Bungifun 1 year ago What an enormously packed presentation! thanks for sharing this! Slowly we progress in knowledge but it just gets more and more complex as we continue to discover the actual workings of nature. How can it not be complex after a few billion years of evolution? We can't imagine how long that is so it is natural that we are surprised about the complexity. 2 cheesey cheesey 3 years ago Was awesome 👍 2 cheesey cheesey 1 year ago Doug Wallace PhD is legend 👍 4 Marty Lawrence Marty Lawrence 1 month ago There are FIVE information codes in every cell, aside from blood cells. The five are the DNA code, the mtDNA code, the epigenome code, the 'sugar' code that lines the surface of every cell, and the lipid code making up cell membranes. All these had to work in unison. The makeup of these for life are mathematical impossibilities-by-chance. To say the ribosome sums up evolution is ludicrous. That is defined as a 10^50 or more. It's far too complex without outside intelligence to make it happen. On top of this, the Intelligent Designer is a master chemist with 65 different hormones in the human body. We are a creation.. Not an evolution. 1 Dino Miles Dino Miles 2 years ago Genius! The question is what can we do to optimize our health?? 5 Dr. Big Sister Dr. Big Sister 3 years ago Found this by reading a review from Jack Kruse on Dr. Goldner's amazon book. Funny how that works. 19 nanotedot nanotedot 3 years ago Energy is life, then mitochondrias are life. Mitochondrias and the 2nd Law of Thermodynamics are the essence of everything. 5 Andre Reog Andre Reog 7 months ago 👍🏿🙏🏿 fred jones fred jones 1 year ago This fella needs to do the "how to give a talk 101" course; he speaks far too quickly; it would seem he is showing off; he races through (at 16-17 mins) explaining mitochondrial genes; being in the nucleus; if everyone was able to keep up with the machine-gun pace of the talk; why bother to give the talk; 3 Marshall Edwards Marshall Edwards 2 years ago Although this is great teaching, don't forget the much bigger picture. We were created by our creator. We did not evolve from monkeys. God is the one and only perfect creator and designer of us and our universe. Please read His love letter given to us, the Bible, cover to cover. Please learn about God's son, Jesus Christ, the only one who died for our sins. Our body is temporary. Our spirit will live forever. Don't sacrifice your soul just to prolong your temporary carcass.