Basketball - His Last Chance, Charles Barkley

Basketball - His Last Chance 86,717 viewsFeb 13, 2013 373 DISLIKE SHARE DOWNLOAD CLIP SAVE Wiffle 18.6K subscribers Some edits and cuts in this classic old vhs special on Charles Barkley, which highlights his Sixers Career and his first year in Phoenix. Music SONG Into the Sunset-14494 ARTIST Mark Russell, Simon Russell ALBUM ATMOS41_Ethereal Journeys 2 LICENSES Get YouTube Premium Music 45 Comments rongmaw lin Add a comment... ChrisJWatts504TV ChrisJWatts504TV 6 years ago 3:40 - R.I.P. Moses Malone :-( 16 Myke Mynah Myke Mynah 10 days ago Love his honestly. He's never been a phony. A true superstar from back in the good ol days. 4 Intel-Pick Intel-Pick 7 years ago Great Documentary. 44Points 25 rebounds !!!! Are you kidding me ? 6 adi jaya adi jaya 6 years ago Charles Basketball Barkley. My first NBA idol, I was 13 in '93 finals 3 wmden1 wmden1 3 hours ago (edited) Great documentary, I guess you would call it, on Charles Barkley. Inspirational and more. Barkley is one of the all-time greats, but I was not a fan when he played for Philadelphia. I have watched a few snippets of Inside the NBA and I believe, now and like that he strongly appears to be a very genuine person, and tells it like it is, regardless of consequences, to a reasonable point, anyway. An example from that program; Kenny Smith, I believe it was, asked Shaq; "Are you better than Wilt?". Shaq; "Yes, I am better than Wilt." Barkley; "You ain't better than Wilt." Carlos Washington Sr Carlos Washington Sr 9 days ago Man when I was in highschool I loved him in Auburn but 3 years in the L I realized this dude is and always was a BULLY....BUT I loved his game..but I hate bullies 2 JAMIL HOSTILE JAMIL HOSTILE 7 years ago Barkley was a complete player! He raised the bar! 8 Gambit Wu Gambit Wu 9 days ago (edited) First off, WDE!!! But how did this man have "weight problems" when he wasn't even all that big back in the day? He had skinny ass arms and everything. And let me add that Dan Majerle was the truth 2 Ball Game Ball Game 23 hours ago Favorite player of all time 💪🏽 The Rose in the garden The Rose in the garden 6 years ago My God KJ,Majerle and Ainge were a sight too see on the court 1 Rogelio Vitug Rogelio Vitug 3 days ago not that tall , but a very strong player.. 1 Robert Popescu Robert Popescu 6 years ago What a great channel! 1 Se 2333 Se 2333 6 years ago Never again will we see a 6'4 fat guy dominate like chuck 15 dave474c dave474c 9 years ago @ 5:19 Is that a block or a steal? 2 Rogelio Vitug Rogelio Vitug 3 days ago My idol next to MJ dave474c dave474c 9 years ago Yeah I know. But statistically it'd count as both. Block 1st, then steal. 1 Elvis Presley Elvis Presley 1 day ago <3 me some Chuck ! 1 frederickcook87 frederickcook87 2 weeks ago ✊🏾❤️✊🏾 Donald Pace Donald Pace 5 years ago RIP MOSES 2 rolla rolla 6 years ago jordan and barkley should have played together in the same team... Lorenzo Dawkins Lorenzo Dawkins 5 months ago 20:37 Ummmm okkkkk buddy wild to say that Spencer Chatfield Spencer Chatfield 9 years ago is it just me or does paul westphal look look like bill murray Elbio Elbio 2 weeks ago Is Captain Sisko narrating? 3 marktarmannpiano marktarmannpiano 10 days ago Captain Cisco of deep space 9 doing the voice over? 1 dizM0nkey dizM0nkey 1 month ago Nobody do the voodoo like you do. Ball Don't Lie Ball Don't Lie 6 years ago @dave474c block + rebound.. Mike valenzula Mike valenzula 6 years ago i wouldnt mind if the hometown fans booed me..they can do why they want ..they are paying my salary.. 2 Dante Fajardo Dante Fajardo 5 years ago Philadelphia is really the worst franchise throughout the history of the NBA. If you start your career there then you would be having a lot of problems with your career. Bob James Bob James 6 years ago Why is Dracula narrating this? 2 Spencer Chatfield Spencer Chatfield 9 years ago block

NBA Draft 1st Picks Every Year 1947-2022,, plus Wilt Chamberlain's Career and highlight of Larry Bird performance plus David Lee nba profile

The TOP 30 NBA Players Of 2022-2023 26,218 viewsJul 29, 2022 ,Plus highlight of Derrick Rose

林昭亮 , 小提琴家 Cho-Liang Lin , Violinist

米芾与苏东坡的故事

米芾与苏东坡的故事 相交20年，乐与师徒共， 著名书法家刘宏伟： 东坡是才子，米芾是觉者 大江东去，浪淘尽，千古风流人物。 苏轼，一代文豪，才华横溢，冠绝古今。 他的人，应该能配得上他词中的风流人物。 其诗，其词，其散文，其书画，成就非凡。 诗文与同时代的黄庭坚并称“苏黄”。 词作豪放一派与辛弃疾并称“苏辛”。 散文与欧阳修并称“欧苏”，为“唐宋八大家”之一。 书法位列“宋四家”之首。 善于绘画，尤擅墨竹、怪石、枯木等。 他还是有名的美食家。 说到苏轼的书法，通常会与他的诗画相提并论。 著名书法家刘宏伟说，苏东坡的书法审美与他的字画一样，突出在意境上。 不满足于外在的造型与形态，而在于表达笔墨背后的主观心意。 米芾呢，跟苏轼不是一个方向。 很多时候甚至是针锋相对的。 峻利爽快，风樯阵马。 米芾的书法，让人看着，有一种沉着痛快之感。 两个人年岁相差较大，相差14岁。 文学诗文也罢，书画也罢，仕途也罢，米芾是晚辈。 从其文化修养上看，苏轼明显高于米芾。 然就书法本身而言，连苏轼本人也认为，米芾后来书法超过北宋的所有书家。 包括苏东坡。 从留存的资料看，两人间，有过数次交集。 那么他们究竟是怎样的关系？ 是有知心好友呢，还是某些人所猜测的客套而已。 刘宏伟说，关系非浅。 多半是知己。 传说，米芾听说苏轼要来看他。 提前准备了美酒与饭菜。 还有两方条案。 两人见面后，边吃边谈，边谈边写。 当日说过的话，写过的书法，平时莫及。 痛快之极。 快慰平生。 以此看，两人的关系，应该非常深厚。 两人有过长达20年的交往。 相传，米芾的书法是在苏轼的指点下，发生质变。 无论东西，只论喜欢。 民间传说，米芾就是神笔“转世”。 平生于书法最为用功。 为书法而生，书法就是他的生命。 米芾习书，自称“集古字”。 学谁像谁，写谁是谁。 临帖临到以假乱真的地步。 说有一个书法商人想把一副唐代书法家的真迹卖给他。 米芾说，你先放在我这里，让我想想。 数人后，米芾拿出一模一样的两幅书法作品。 书法商审视了许久，分不清真假。 最后把米芾临写的字拿走了。 那一年，米芾31岁，苏轼45岁。 苏轼出任杭州太守，途经扬州，与米芾相见。 也许是米芾前往拜谒，也许是苏轼招见。 米芾为人疏狂、不合流俗。 东坡性格豪爽、旷达大度。 两人性格相异，却一见如故。 唱和交好。 且同是好茶之人。 窗外炉烟自动，开瓶试一品香泉。 轻涛起，香生玉尘，雪溅紫瓯圆。 这是米芾的诗。 品茗之余，东坡对米芾的书法大为赞赏，并为其指明了方向。 说米芾的书法，当取晋人。 米芾书法的传统功底，当世无人可及。 米芾学颜真卿、欧阳询，学褚遂良，学沈传师、段季展。 见面后，据米芾自述，专学晋人，其书大进。 中国书法，历数千载演进，在宋代是一个转折与高峰。 而米芾就是站在这个高峰上的顶尖人物。 能实践古人，又能出新意。 他的行书被称为史上最讲究技法的人。 于书法之痴迷，于书法之用功，于书法之纯粹，当世无出其右者。 据传，米芾初次造访苏轼，正是其书法遭遇瓶颈之时。 也是苏轼被贬，落魄之日。 两人惺惺相惜，可见确也是相互懂得的。 米芾行书法帖《乡石帖》，又名《紫金帖》。 新得紫金右军乡石，力疾书数日也。 吾不来，果不复用此石矣！ 这是米芾写的随笔。 说苏子瞻，也就是苏轼，借走了他的紫金砚台。 紫金又叫琅琊紫金，是唐宋时用来制作名砚的名石。 苏东坡太喜欢这块紫金砚台了，要儿子将此砚作陪葬品。 米芾不干：传世之物，岂可与清净圆明、本来妙觉、真常之性同去住哉！ 也就是以婉转的口吻把砚台要回来。 以此看两人的关系似兄弟也。 那年，苏轼64岁，米芾50岁。 两人相见南京，游金山时，有人请苏轼题词。 苏轼说，有元章在。 今则青出于蓝矣。 元章就是米芾。 苏轼觉得，他这个徒弟，已超出了师父。 此为两人最后一次见面。 两人彻夜交谈，喝了过量冷饮。 苏轼闹肚子，米芾也曾送药，但是并不见效。 一个月后，苏轼客死常州。 于苏轼的书法，米芾是喜欢的。 他一边偷偷珍藏着，一边骂着。 米芾几乎骂遍了当世的书家。 这个人，吹起牛来，骂骂好友也不稀罕。 苏轼讲求“萧散简远”、“清新”、“简古”、“淡泊”。 米芾推崇“平淡天真”和“高古”。 两人晚年，其实书论与追求已有所接近。 但是，两人还是有区别的。 苏轼重意外之象，讲究意境之美。 当你纠缠于审美的时候，就有了一定自我痕迹。 而米芾更多的时候，落笔直书。 东坡有云，六十惊觉，知元章不尽。 意思是说，米芾的笔法直接自然太高妙了。 从这种意义上说，单就书法论，苏轼为才子，米芾为觉者。 可是米芾的影响仅在书画圈内。而苏轼影响了社会各个阶层。 苏轼为才子，米芾为觉者。

David Sinclair Found the Fountain of Youth? Not yet­!

Has Harvard’s David Sinclair Found the Fountain of Youth? Not yet­—but he sure is getting rich, famous, and having a blast while trying. by CATHERINE ELTON· 10/29/2019, 11:50 a.m. Read all about the latest gym openings, healthy events, and fitness trends in our twice weekly Wellness newsletter. EMAIL ADDRESS Portrait by Ken Richardson Like any dreamer, David Sinclair has a tendency to live in the future. The first time that thought crossed my mind, we were hurtling toward Worcester in his Tesla, on our way to visit one of his many companies working on an antidote to aging. Sinclair told me he’d recently discovered, using a health-tracking device, that he’s shaved a decade off his life: Biologically speaking, he is now 40, not 50. I took a good look at him. Except for the pillow he sat on while he drove, the wrinkles that formed around his eyes when he flashed his mischievous grin, and the note scrawled on the back of his hand (lest he forget something he has to do), there was no way in hell he looked anywhere near 50. He is slight of build, with nary a gray hair, and bears a passing resemblance to that forever child Alfred E. Neuman. He even says he feels like a kid, too. I had skipped breakfast that morning to get a feel for what it’s like to be Sinclair, whose habit of not eating anything until the afternoon—along with ingesting a mysterious medley of pills—is one of his many life-extending practices. When I asked about one of the drugs he takes, he reached into his pocket and pulled out a capsule filled with a white powder that he packages himself in his lab. He has told reporters that the substance inside is a miracle molecule. I plucked it from his hand and put it in my own. It felt so light in my palm. So easy to believe. And that is precisely the problem. ADVERTISING From time immemorial, people have been on a fantastical quest for a substance that would extend life, or even grant immortality. The medieval alchemists sought the elixir of life. Explorer Ponce de Leon looked for the fountain of youth in what is now the southern United States but, in an ironic twist of fate, found Florida, a place where people go to grow old and die. As the centuries wore on, traffic in life-extending substances and practices became the clear bailiwick of snake-oil salesmen, charlatans, and quacks. More recently, though, longevity has become the stuff of legitimate science. Sinclair is a superstar among a group of researchers who have harnessed science and technology’s latest advances in an effort to parse out, for the very first time, the biological mechanisms of aging in hopes of slowing or even reversing the process. The goal of this field is not to make us young for youth’s sake, but to address the single greatest risk factor for heart disease, cancer, diabetes, dementia, and many other forms of modern-day suffering: aging. This radical new thinking about medicine maintains that if we can address the upstream cause of these diseases, we can cure them all at once (instead of relying on the current Whack-a-Mole approach) and increase the number of years people live with good health. But it is also true, experts say, that eliminating all of these diseases of aging will make people live longer. “We are on the verge of a public health breakthrough of the kind we have never seen before,” says S. Jay Olshansky, a professor of public health who studies demographics and aging at the University of Illinois at Chicago. “It is not trivial. This is bigtime.” Sinclair deserves much of the credit for getting the field to where it is today. The Australian-born Harvard Medical School professor of genetics has had countless discoveries published in the most respected scientific journals in the world and has received dozens of scientific prizes and honors. Last year he was appointed an Officer of the Order of Australia for his contributions to humanity. Wealthy investors, including WeWork cofounder Adam Neumann, have bet hundreds of millions of dollars on his science and invested in the 17 companies he’s founded. When Sinclair’s book, Lifespan: Why We Age—and Why We Don’t Have To, was released in September, it reached number 11 on the New York Times bestseller list in just over a week. At the same time, Sinclair is one of science’s most controversial figures, regarded by many as a slick salesman who overhypes his work and its potential. Some critics cringe when he speaks of miracle molecules and everlasting life. Others whisper that his science may not be completely sound. Still others roll their eyes over his habit of taking drugs that haven’t been proven to delay aging in anyone who isn’t a mouse. The prevailing wish among his doubters is for him to simply keep his mouth shut. “He is a complicated guy,” says Steven Austad, a professor of biology who studies aging at the University of Alabama at Birmingham and is a friend of Sinclair’s. “He’s a superb scientist, as well as a superb salesman. You talk to him about science and you won’t find many more knowledgeable, incisive experimentalists as David. And then you can listen to the stuff he says on TV and be like, What the hell is he talking about? ” Sinclair’s bold statements and pill-popping habits have ruffled feathers closer to home, too—at the very institution that employs him. “He does do research and he gets it published in peer-reviewed journals, and if he just did that, it’d be fine,” says a Harvard Medical School professor who asked to remain anonymous. “But then he speaks out about how he makes himself young and says stuff that would be embarrassing for any normal scientist to say.” In other words, in an increasingly legitimate field of science desperate to distance itself from the alchemists and quacks of yore, Sinclair presents somewhat of a problem. As a brilliant scientist in the lab, he is a major asset to his field’s eternal quest for legitimacy. Let loose in the world, though, the self-described “Star Trek wannabe,” who’s eager for the future to arrive as fast as possible, is somewhat of a liability. He may very well be the man who will unlock the secret to extending life some 10, 20, or even 30 years—so long as he doesn’t get lost searching for the fountain of youth along the way. Sinclair can remember with startling clarity the day he first learned about death. He was with his beloved grandmother at her home in Turramurra, a leafy suburb of Sydney on the edge of the bush. They were seated on the floor playing when she told him his cat would only live to about 15. He was shocked. And the news only got worse. Everybody dies, she told him. It is not surprising for children to be disturbed when they learn about mortality, but most of them move on, squirreling away the fear and dread until it comes bubbling back to the surface with the appearance of gray hairs, knee pain, and mental lacunas. Sinclair’s trajectory was slightly different. In a sense, he never got over it. While his biochemist parents worked, Sinclair spent most of his childhood with his fun-loving, free-spirited grandmother, who admonished him to never grow up. By the time he enrolled at the University of New South Wales to study biochemistry, he was convinced that science would one day catch up with his grandmother’s ideas and people would be able to stay young forever. He believed, however, that he had been born too early to see it. He told his friends at school over coffee that they were likely to be the “last of thousands of generations to live the sad existence of such a short life.” But no sooner had he thought it, he says, than he considered the fact that maybe he was wrong. Maybe it could happen in his lifetime, and maybe he could be a part of it. Sinclair had found his life’s purpose. His next stop was 10,000 miles away at MIT, where at the tender age of 24 he became a postdoc in the lab of Leonard Guarente, who had just started studying aging in yeast. Sinclair’s colleagues remember him as someone who was aggressive, ambitious, and tireless: He was often the first to come into the lab and stayed as long as he could before dashing to catch the last train of the night. His colleague Shin-ichiro Imai, a professor of developmental biology at the Washington University School of Medicine who first met Sinclair in Guarente’s lab, says Sinclair had a “keen eye for capturing novel concepts and, based on that foundation, building new lines of research faster than anyone else.” At the time, aging research, once considered a fringe science, was still in its infancy, but Sinclair was determined to propel it to legitimacy. Three years into his time at MIT, he made a groundbreaking discovery that explained, for the first time, a mechanism of aging in yeast and opened up the possibility of one day manipulating the process in humans. From there, Sinclair’s career took off like a rocket. He soon left MIT to run his own lab at Harvard Medical School and became an assistant professor of genetics, continuing to build on discoveries made at Guarente’s lab about sirtuins, a family of proteins that exists in all living beings. These proteins are usually dormant, but when activated through stressors (such as restricting calories), they can enhance health and extend life in yeast. Sinclair was determined to find a substance that could mimic the effects of restricting calories in yeast, something that could one day be turned into a medicine that cures aging. True to form, he got to work, harder and faster than anyone else, Imai says. He screened some 20,000 substances until, one day, his collaborator called to say that he’d gotten a hit: resveratrol, a molecule found in red wine that has long been suspected to play a role in human health. Sinclair couldn’t believe what he was hearing and knew others wouldn’t, either. So he set out to disprove the finding right on his dining room table, where he lined up a series of petri dishes filled with yeast that had been fed different substances. When he discovered that the dish with yeast that lived 50 percent longer had been fed resveratrol, he cried out to his wife, “I think we have found something important here.” The discovery was the start of another phase in Sinclair’s career, one in which wealthy investors played as much of a role as the scientific community. In 2004, with the help of serial biotech entrepreneur Christoph Westphal, he founded a company called Sirtris Pharmaceuticals to pursue clinical-stage drugs inspired by the resveratrol molecule. At the time, it was almost unheard of for a scientist in the aging field to start a company. “David was a pioneer in merging academic and commercial research,” Austad says. “A lot of scientists would have liked to do what David did, but they didn’t know how, or have the appropriate skills to raise the money and convince the investors that this science was promising a revolution in health. David did.” Meanwhile, in his lab, Sinclair pushed his studies up the evolutionary chain into mice, and in 2006 published the paper that would change his life: a study showing that overweight rodents fed resveratrol aged slower and stayed healthier than ones that did not consume the substance. It was an instant sensation, landing on the front page of the New York Times. Sinclair gave a few dozen interviews before sitting down, relaxed and charming, for the Charlie Rose show. A 60 Minutes special on resveratrol wasn’t far behind, and soon he was telling Morley Safer we could expect an FDA-approved pill in five years’ time. Resveratrol, he once boasted to a reporter from the magazine Science, was “as close to a miraculous molecule as you can find.” In no time, Sinclair went from being a scientist toiling away in a lab to someone whom strangers recognized on the street. He became a longevity guru to legions of people hoping to glean insight about how to forestall their own mortality. And, he became rich. Sirtris went public in 2007, and one year later, pharma giant GlaxoSmithKline snatched it up for an astounding $720 million. Resveratrol had made Sinclair famous and wealthy beyond what he had ever imagined, but it was also about to turn him into one of modern science’s most polarizing figures. David Sinclair in his lab at Harvard Medical School. / Portrait by Ken Richardson Sinclair was sitting at his desk at Harvard one day in 2010 when a colleague called to offer his heartfelt sympathies: Pfizer scientists had just released a paper essentially saying that Sinclair’s work on sirtuins was bunk. When he finally got hold of the document himself, Sinclair couldn’t believe his eyes. “It wasn’t clear to me at all that we were wrong,” he told me. “We had data that showed we were right.” And yet, it wasn’t the first time Sinclair’s science had been challenged. A couple of years after his initial groundbreaking yeast study on resveratrol, two of his former colleagues from Guarente’s lab published a paper reporting on their inability to replicate it, suggesting his conclusions were wrong. A few years later, scientists from the pharma company Amgen also raised doubts, claiming Sinclair’s findings were erroneous. The Pfizer paper, though, was different. Not only did one of the biggest pharma companies in the world claim he was wrong on resveratrol, it also stated his entire theory on sirtuins was completely off. In response, Sinclair publicly questioned whether the Pfizer scientists had made mistakes running their experiment—which didn’t exactly go over well. “I was criticized for saying that Pfizer doesn’t know how to make a molecule right,” he explained. As the scientific community continued to raise doubts and gossip behind his back, Sinclair sank to a dark place. “I spent a week in bed,” he told me. “I couldn’t get out. My lab shrunk to, like, four people.” When I asked his assistant if she remembers what it was like when the Pfizer paper came out, she sighed, looked down, and shook her head from side to side: “That was devastating.” Still, it’s hard to keep Sinclair down for long; after all, he lives by the very idea of never say die. When he finally got out of bed, he went back into the lab to prove his naysayers wrong. The day I visited his lab, he stood with his arms crossed and a look of satisfaction on his face as he showed me a framed copy of a 2013 scientific paper that he says settled the debate and proved he was right about resveratrol activating sirtuins. In it, he showed that when scientists genetically engineered cells to change a single amino acid on a sirtuin, resveratrol had no effect on the cells. In the control cells with intact sirtuins, however, resveratrol did have an effect. Not everyone, though, was convinced. “There are lots of people in the field who harbor suspicions [about Sinclair’s science],” one researcher told me. “It is hard to explain how the same lab on multiple occasions over a decade or so can publish multiple pieces of data that other labs can’t reproduce.” What’s more, GlaxoSmithKline halted a Sirtris trial in humans because of potential negative side effects and then shut the company down altogether just five years after buying it. Today, resveratrol is known as the miracle drug that wasn’t. To Sinclair’s credit, none of his scientific papers have ever been retracted—and none of the people who spoke to me about their suspicions of Sinclair wanted their names used. One of them admitted that it might not be his data that critics object to, but rather the way Sinclair talks about his findings. While his colleagues in the aging field overwhelmingly stick to a safe script, describing their research as a quest to extend years of health, Sinclair talks freely and excitedly about extending mortality to 150 years by the end of the century—to say nothing of death eventually becoming a rarity—both of which critics say there is zero science to support. From his exalted platform as a scientist featured on TV and in the New York Times, Sinclair is promising the world that one day soon we’ll be able to get a shot that reverses aging, and when it wears off and the gray hairs sprout again, we’ll simply get a booster. “Does that sound like science fiction? Something that is very far out in the future?” Sinclair asks readers in his book. “Let me be clear: it’s not.” Even the title of his book—the part that says we don’t have to age—elicited an exasperated groan from the Harvard Medical School professor. “What is wrong with the guy that he is compelled to do this?” he asks. “Seen in the best possible way, he is totally convinced that he is the savior of mankind developing the fountain of youth. But you don’t have to hype to do that. Just let the facts play out.” Even his friends call him out for how he talks about his science. “David is a good friend,” Austad says, “but I do think he’s been guilty of making excessive claims.” Despite the resveratrol fiasco, Sinclair hasn’t shied away from making other grandiose promises. One of his more recent molecules of interest is called NMN. It is found in every living cell and boosts levels of something called NAD+, which regulates the mitochondria, or powerhouses, in all of our cells. NAD+ declines with age—unless, that is, scientists like Sinclair can find a way to increase it. Last year, he told Time magazine that NAD+ “is the closest we’ve gotten to a fountain of youth.” If Sinclair’s public comments push past the limits of what most scientists would say, it is also true that his accomplishments in the lab continue to push the limits of science itself. When I met with Sinclair, he told me he is gearing up to publish a paper about how his lab reversed aging in rodents. He described a series of experiments using gene therapy in which he and a group of scientists were able to restore vision in mice with glaucoma as well as in other mice who had their optic nerves (which cannot grow back after the newborn period) crushed. Sinclair’s team had made a handful of old mice young again. In light of the cutting-edge experiments and advances he is making in his lab, I was surprised that Sinclair also continues to study resveratrol. It seems so yesterday. When I asked about it, he assured me with a self-confident nod that he is still bullish on resveratrol. The 2013 paper, the one on his wall he believes vindicated him, didn’t get the word out far and wide enough, he says. That’s why his lab did another experiment—this time deactivating a spot on the sirtuin protein in mice—to show that resveratrol does, in fact, work. He tells me he’s really looking forward to that study coming out to restore faith in resveratrol. And, it seems, perhaps to restore faith in Sinclair, too. “When that one comes in,” he says of the forthcoming paper, “I’m going to drop the mike.” If Sinclair’s public comments push past the limits of what most scientists would say, it is also true that his accomplishments in the lab continue to push the limits of science itself. As Sinclair and I neared our destination in Worcester, I had my head down, furiously scribbling in my notebook, when I felt the car swerve abruptly to the right. I looked up to see Sinclair, visibly frustrated, struggling with the Tesla’s steering wheel. “My car appears to have been set to Mad Max mode,” he said in his pitch-perfect Australian accent. “I promise not to get us killed.” Then he added wryly, “That would be ironic.” It would, indeed. After all, Sinclair is planning on being around for a lot longer than most people think they will. He convinced his dentist to fix some wear on his teeth, a procedure that she told him she’d normally reserve only for teenagers. He dedicated his book to his great-great-grandchildren, whom he is very much looking forward to meeting. To make it until then, he practices calorie restriction, eats a mostly vegetarian diet, and tries to avoid sugar and carbs. On weekends, he exercises at the gym and then sits in a hot sauna before plunging himself into an ice-cold pool, because temperature extremes also kick our cells’ survival instincts into action, he says. Sinclair tracks his biomarkers regularly and takes vitamin D, vitamin K2, and aspirin. And he takes three other substances each morning: resveratrol, NMN, and metformin, a diabetes drug currently being studied for its potential anti-aging effects. The problem, critics say, is that unlike cancer drugs, for instance, nearly anyone can buy something close to the NMN and resveratrol capsules Sinclair is downing at places like the local GNC, where they’re sold as supplements alongside multivitamins and protein powder. Sinclair diligently points out that he is not a medical doctor; that he is not recommending anyone do what he does; and that there is no definitive evidence that any of it helps humans. Still, critics say that when a scientist such as Sinclair tells people what he is taking, it is nothing short of a celebrity endorsement, those caveats notwithstanding. In his defense, he told me he gets dozens of emails and messages every day from people asking him what they—or their pets—should be taking, and that he never makes recommendations. But it’s also hard to imagine people would write to ask him at all if he weren’t talking so publicly—and so often—about his daily regimen. “I like David a lot. We’re very good friends. However, I don’t think that what he’s doing is right,” says Felipe Sierra, the director of the aging biology division at the National Institute of Aging. “I don’t think that people should try it on themselves. And if they do, they shouldn’t publicize it. Researchers do have a responsibility toward the public, and we should be careful about what we tell the public.” Sinclair knows he ruffles feathers: At one point during our day together, I asked him where his family members get their pills from. He raised his eyebrows at me and then said in a Big-Brother-might-be-listening kind of whisper that we were in “territory that could get me called into the office, and it wouldn’t be the first time.” Still, he says he is prepared to deal with the consequences of being honest. What’s more, Sinclair says he has nothing to do with the supplement industry, a claim that is mostly true. All of the companies he has started are working on creating FDA-approved drugs, not supplements. True, years ago he did work as a paid adviser to a resveratrol supplement company, Shaklee, though Sinclair says he cut off that relationship when the company started using his name for marketing. Even if Sinclair isn’t directly profiting when people buy supplements after hearing him speak, he may still be benefiting financially from talking about what he takes. “Think about what the optics would be if someone says, ‘I’ve got this great potential therapeutic intervention,’ and then says they’re not taking it. Suddenly you are putting up red flags about your own science,” Olshansky, the Illinois professor, says. “So I can see why somebody who has a financial interest in a molecule would take it and brag about it. If it helps them get more money to do research, that may be one of the reasons they do it.” Sierra, for his part, admits that as much as he dislikes when Sinclair shares what he is taking, “it is probably good for commercial purposes.” Whether or not his personal habits have helped Sinclair’s bottom line, there’s no doubt he’s raised a ton of funding and used it to start a slew of companies. Seven of them fall under the umbrella of Life Biosciences, a Boston holding company he cofounded with Australian investor Tristan Edwards with the goal of building clinical-stage biotech companies by harnessing the best science in the aging field. Edwards had been interested in the longevity space and searched for a scientist to work with. He had a call with Sinclair and was so convinced by what he heard that before he got off the phone, he had already booked a flight to Boston. The firm raised $25 million while in stealth mode in 2017 and has since raised $500 million more. Another company, MetroBiotech (which falls under the holding company EdenRoc Sciences), is pursuing drugs inspired by the NAD+ booster NMN. That’s the one we were on our way to visit when Sinclair’s Tesla tried to kill us. Upon our arrival, two men looking slightly disheveled and both wearing Hawaiian shirts greeted us; these were the organic chemists tasked with developing molecules that may one day become an FDA-approved drug. As they took me back to their lab, I noticed the paunch on one of them, the wrinkles on the other, and the fact that what little hair either of them had left on their heads was somewhere between gray and white. I lowered my voice and asked, “So are you guys, you know, taking the stuff?” “Of course not. We are scientists!” one of them exclaimed, looking at me like I was the mad scientist in the room. It doesn’t take a PhD to know that the fact that two guys who aren’t taking NMN look old proves absolutely nothing. But it did make me feel a little more hopeful to learn that they were not. And the funny thing is that later in the day, when I asked Sinclair why he takes unapproved drugs knowing that there could be risks (and how much it pisses people off), he said the very same thing: “I take them because I am a scientist.” Then, in total deadpan, he gave me another reason. “And because I would like to outlive my enemies.” David Sinclair with his wife, Sandra Luikenhuis, at the Time 100 party after the publication named him one of the world’s most influential people in 2014. / Getty Images Sinclair and I were supposed to be at the gym at 5 p.m. to meet up with his 12-year-old son, Ben, and his about-to-be-80-year-old father. Because we were running late, he asked his wife to send his gym clothes with his dad. When we arrived, Sinclair came out of the locker room in his dress shoes. His wife, despite taking NMN herself, had forgotten to send his sneakers. Luckily, the trainer had an extra pair, and the Sinclair family got down to business. First up were dead lifts. Ben had a go and did pretty well for a kid his age. Then Sinclair went. He started to wince midway into the second set but made it through. Finally, his father had his turn, dead-lifting 95 and then 115 pounds like it was nothing. The trainer told me most of his 80-year-old clients are working on maintaining their balance and lifting themselves out of chairs. Sinclair’s dad is killing it in the gym. “Well, I suppose the only thing this proves is how useless I am,” Sinclair told me, frowning. Of course, he is hoping it means something else. His father has been taking NMN for two years, and since starting, Sinclair said, it has changed his life, his attitude, and his energy levels. It has returned to him his joie de vivre. When I asked Sinclair’s dad directly how the pills are going for him, I realized that Sinclair definitely did not get his salesmanship skills from his father. “Can’t tell,” he told me flatly, with a shrug. “But all my friends are dying or going downhill and I’m not.” Not only are Sinclair’s dad and wife taking NMN, but so are his two dogs. His younger brother grew gray hairs and developed wrinkles before he accused Sinclair of using him as a negative control in his little family experiment. Sinclair admits the thought did cross his mind, but blood is thicker than science, and now his brother is on the regimen, too. Even several of his graduate students are taking some of the pills. When the postmenopausal mother of one of those grad students also began taking it, she started menstruating again. (Perhaps unsurprisingly, Sinclair has a fertility company, too.) There was one person who never got the chance to take NMN, however, and it seems to haunt Sinclair. His mother was diagnosed with lung cancer at age 50 and had a lung removed. She managed to live another 20 years with one lung, which Sinclair says he would like to think had something to do with the fact that she took resveratrol. At the end of her life, when she took a turn for the worse, Sinclair packed some NMN in his suitcase and boarded a flight to Australia. When he got there, she started doing so much better that the doctors took her off her respirator, and she never took the NMN. She died unexpectedly 12 hours later. “I thought the NMN would save her,” he admits. “Wouldn’t anybody do whatever they can to try to save their mother?” As their workout wore on, Sinclair’s son Ben had something he wanted to tell me. He wanted me to know that he would like to continue his father’s work “if he ever dies.” I was distracted from the tenderness of this statement by the presence of a single preposition. “If?” I asked. “He may never die,” he said. I shrugged and smiled, but inside I was thinking that if he isn’t joking, someone is in for a real shocker. Earlier in the day, Sinclair told me he was such a straight-talker that he had ruined the illusion of Santa Claus for his children—and yet here his son could be thinking his father might never die. Such is life in the Sinclair household. Still, not everyone in the family wants to see people live forever. Sinclair’s oldest daughter doesn’t agree with his work and has zero qualms about letting her dad know it. She has asked him why, when previous generations have screwed up this planet so royally, he thinks it’s a good idea to have the people who did the damage hang around any longer. She is not the only one. Emory University bioethicist Paul Root Wolpe, for instance, has called the longevity field a narcissistic quest and points out that generational shifts are necessary for innovation, progress, and social change. As if in response, Sinclair’s book has an end section in which he delves into many ways to fix the world he wants to create. There is, he argues, a solution to everything in a reality where people live to 150—overpopulation, inequality, natural-resource limitations—if you are as hopeful as he is. Just as I was finishing up this piece, in fact, scientists published a study linking optimism to longevity—meaning Sinclair could stand to add even more years to his life. Indeed, if I squint hard enough, I can practically see him growing younger before my very eyes. Read More About: Harvard Medical School Health Long Reads You Might Also Like Kripalu Is Shutting Down until 2021 and Laying Off 450 Employees Is There Such a Thing as Healthy Tech Boundaries during Social Isolation? Hunting for the Next Moderna Ad ChoicesSPONSOR CONTENTBest Coffee Tip Ever, Don’t Throw Away Your Keurig Machine Best Coffee Tip Ever, Don’t Throw Away Your Keurig Machine by Angelino's Coffee SPONSOR CONTENTDentists Call This New Teeth Whitening Tool Dentists Call This New Teeth Whitening Tool "State Of... by Cleaner Smile SPONSOR CONTENTThe Best Kept Secrets to Self-Transformation: Start Small The Best Kept Secrets to Self-Transformation: Start Small by GT's Living Foods TRENDING Nine of the Best Golf Courses You Need to Try near Boston Where to Get the Best Massage in Boston Seven New England Wellness Retreats to Visit Women, Weed, and Sex: What You Need to Know JC Monahan: Breaking My Silence The Ultimate Guide to Weight Machines at the Gym Where to Find Outdoor Pools in Boston, and When They Open IN THIS SECTION Aging is a disease: "Lifespan" by David Sinclair Dima Syrotkin 🇺🇦Click here to view Dima Syrotkin 🇺🇦’s profile Dima Syrotkin 🇺🇦 CEO and PhD Researcher. Bring your people on board with corporate change. People matter. Published Feb 26, 2020 + Follow I will preface this review with just one thought: if this is true, sooner or later longevity will COMPLETELY change who we are as humankind. My grade of the book: A+ (using the American grading system) - one of the best! Aging Once you recognize that there are universal regulators of aging in everything from yeast to roundworms to mice to humans . . . . . . and once you understand that those regulators can be changed with a molecule such as NMN or a few hours of vigorous exercise or a few less meals . . . . . . and once you realize that it’s all just one disease . . . . . . it all becomes clear: Aging is going to be remarkably easy to tackle... Easier than cancer. “Every death is violent,” he said in 2010. “There is no natural death, unlike the picture we like to paint of the father who dies quietly in his sleep, surrounded by his loved ones. I don’t believe in that.” Small numbers of senescent cells can cause widespread havoc. Even though they stop dividing, they continue to release tiny proteins called cytokines that cause inflammation and attract immune cells called macrophages that then attack the tissue. Being chronically inflamed is unhealthy: just ask someone with multiple sclerosis, inflammatory bowel disease, or psoriasis. All these diseases are associated with excess cytokine proteins. Inflammation is also a driving force in heart disease, diabetes, and dementia. It is so central to the development of age-related diseases that scientists often refer to the process as “inflammaging.” And cytokines don’t just cause inflammation; they also cause other cells to become zombies, like a biological apocalypse. When this happens, they can even stimulate surrounding cells to become a tumor and spread. This is where “antagonistic pleiotropy” comes into play: the idea that a survival mechanism that is good for us when we are young is kept through evolution because this far outweighs any problems it might cause when we get older. Yes, natural selection is callous, but it works. WE ARE ANALOG, THEREFORE WE AGE. According to the Information Theory of Aging, we become old and susceptible to diseases because our cells lose youthful information. DNA stores information digitally, a robust format, whereas the epigenome stores it in analog format, and is therefore prone to the introduction of epigenetic “noise.” An apt metaphor is a DVD player from the 1990s. The information is digital; the reader that moves around is analog. Aging is similar to the accumulation of scratches on the disc so the information can no longer be read correctly. Today, many of my colleagues are just as optimistic as I am, even if they don’t admit it publicly. I’d wager that about a third of them take metformin or an NAD booster. A few of them even take low doses of rapamycin intermittently. We’re on the cusp of upending nearly every idea we’ve ever had about what it means to be human. And that has a lot of people saying not just that it can’t be done but that it shouldn’t be done—for it will surely lead to our doom. “A new scientific truth does not triumph by convincing its opponents and making them see the light,” Planck wrote shortly before his death in 1947, “but rather because its opponents eventually die, and a new generation grows up that is familiar with it.” “Every aspect of job performance gets better as we age,” Peter Cappelli, the director of the Wharton Center for Human Resources, reported after he began to investigate the stereotypes that often surround older workers. “I thought the picture might be more mixed, but it isn’t. The juxtaposition between the superior performance of older workers and the discrimination against them in the workplace just really makes no sense.” Aging disables 93 percent of people over the age of 50, but in 2018 the NIH spent on aging less than a tenth of what was spent on cancer research. There are several ways to speed innovation to find and develop medicines and technologies that prolong healthy lifespan, but the easiest is also the simplest: define aging as a disease. Nothing else needs to change. Researchers working on aging will compete on equal footing with researchers working to cure every other disease in the world. This is what I want to change—more than anything else in the world. I want everyone to expect that they will meet not only their grandchildren but their great-grandchildren and their great-great-grandchildren. Generations upon generations living together, working together, and making decisions together. We will be accountable—in this life—for the decisions we made in the past that will impact the future. General advice If you’ve had your genome analyzed, you can check if you have any of the known variations of FOXO3 that are associated with a long life. To engage our longevity genes fully, intensity does matter. Mayo Clinic researchers studying the effects of different types of exercise on different age groups found that although many forms of exercise have positive health effects, it’s high-intensity interval training (HIIT)—the sort that significantly raises your heart and respiration rates—that engages the greatest number of health-promoting genes, and more of them in older exercisers. Exposing your body to less-than-comfortable temperatures is another very effective way to turn on your longevity genes. In 2018, a peer-reviewed study published by the team at InsideTracker and me, showed that biotracking and computer-generated food recommendations reduce blood sugar levels as efficiently as the leading diabetes drug, while optimizing other health biomarkers, too. Diet Eating more vegetables, legumes, and whole grains, while consuming less meat, dairy products, and sugar. After twenty-five years of researching aging and having read thousands of scientific papers, if there is one piece of advice I can offer, one surefire way to stay healthy longer, one thing you can do to maximize your lifespan right now, it’s this: eat less. On average, Americans consume more than three times the amount of food they need to survive and about 250 times as much water. Over time, some of these ways of limiting food will prove to be more effective than others. A popular method is to skip breakfast and have a late lunch (the 16:8 diet). Another is to eat 75 percent fewer calories for two days a week (the 5:2 diet). If you’re a bit more adventurous, you can try skipping food a couple of days a week (Eat Stop Eat), or as the health pundit Peter Attia does, go hungry for an entire week every quarter. Study after study has demonstrated that heavily animal-based diets are associated with high cardiovascular mortality and cancer risk. Processed red meats are especially bad. Hot dogs, sausage, ham, and bacon might be gloriously delicious, but they’re ingloriously carcinogenic, according to hundreds of studies. Smoking We know that smoking accelerates the aging clock and makes you more likely to die than a nonsmoker—15 years earlier, on average. There aren’t many legal vices out there that are worse for your epigenome than the deadly concoction of thousands of chemicals smokers put into their bodies every day. There’s a reason why smokers seem to age faster: they do age faster. The DNA damage that results from smoking keeps the DNA repair crews working overtime, and likely the result is the epigenetic instability that causes aging. The levels of DNA-damaging aromatic amines in cigarette smoke are about fifty to sixty times as high in secondhand as in firsthand smoke. Supplements People taking metformin were living notably healthier lives—independent, it seemed, of its effect on diabetes... Except for an extremely rare condition called lactic acidosis, the most common of the side effects is some stomach discomfort. In mice, even a very low dose of metformin has been shown by Rafael de Cabo’s lab at the National Institutes of Health to increase lifespan by nearly 6 percent, though some have argued that the effect is due mostly to weight loss.17 Either way, that amounts to the equivalent of five extra healthy years for humans, with an emphasis on healthy—the mice showed reduced LDL cholesterol levels and improved physical performance.18 As the years have gone by, the evidence has mounted. In twenty-six studies of rodents treated with metformin, twenty-five showed protection from cancer. A study of more than 41,000 metformin users between the ages of 68 and 81 concluded that metformin reduced the likelihood of dementia, cardiovascular disease, cancer, frailty, and depression, and not by a small amount. In one group of already frail subjects, metformin use over the course of nine years reduced dementia by 4 percent, depression by 16 percent, cardiovascular disease by 19 percent, frailty by 24 percent, and cancer by 4 percent. The resveratrol-fed yeast were slightly smaller and grew slightly more slowly than untreated yeast, getting to an average of thirty-four divisions before dying, as though they were calorie restricted. The human equivalent would be an extra 50 years of life. We saw increases in maximum lifespan, too—on resveratrol, they kept going past 35. We tested resveratrol in yeast cells with no SIR2 gene, and there was no effect. We tested it on calorie-restricted yeast, and saw no further increase in lifespan, suggesting that the same pathway was being activated; this was how calorie restriction was working. When resveratrol is combined with intermittent fasting, it can greatly extend both average and maximum lifespan even beyond what fasting alone accomplishes. Resveratrol wasn’t very potent and wasn’t very soluble in the human gut, two attributes that most medicines need to be effective at treating diseases. We find NMN to be more stable than NR and see some health benefits in mouse experiments that aren’t seen when NR is used. But it’s NR that has been proven to extend the lifespan of mice. NMN is still being tested. So there’s no definitive answer, at least not yet. What Sinclair does • I take 1 gram (1,000 mg) of NMN every morning, along with 1 gram of resveratrol (shaken into my homemade yogurt) and 1 gram of metformin.7 • I take a daily dose of vitamin D, vitamin K2, and 83 mg of aspirin. • I strive to keep my sugar, bread, and pasta intake as low as possible. I gave up desserts at age 40, though I do steal tastes. • I try to skip one meal a day or at least make it really small. My busy schedule almost always means that I miss lunch most days of the week. • Every few months, a phlebotomist comes to my home to draw my blood, which I have analyzed for dozens of biomarkers. When my levels of various markers are not optimal, I moderate them with food or exercise. • I try to take a lot of steps each day and walk upstairs, and I go to the gym most weekends with my son, Ben; we lift weights, jog a bit, and hang out in the sauna before dunking in an ice-cold pool. • I eat a lot of plants and try to avoid eating other mammals, even though they do taste good. If I work out, I will eat meat. • I don’t smoke. I try to avoid microwaved plastic, excessive UV exposure, X-rays, and CT scans. • I try to stay on the cool side during the day and when I sleep at night. • I aim to keep my body weight or BMI in the optimal range for healthspan, which for me is 23 to 25. If I do take a supplement, I look for a large manufacturer with a good reputation, seek highly pure molecules (more than 98 percent is a good guide), and look for “GMP” on the label, which means the product was made under “good manufacturing practices.” Nicotinamide riboside, or NR, is converted to NMN, so some people take NR instead of NMN because it is cheaper. === Thanks for sticking till the end! I publish book reviews every Wednesday. Are you curious about what I do in my job as a startup CEO? We coach employees via Teams/Slack to drive agile and digital transformation, change management, learning, sales. Working with Bayer, Posti, Futurice. Winner of DigiEduHack and Sanako EdTech Hackathons. http://panda-training.com 9 3 Comments Like Comment Share Lauri Paloheimo Lauri Paloheimo What would you do with a thousand years for living? Like Reply 1 Like 2y Dima Syrotkin 🇺🇦 Dima Syrotkin 🇺🇦 Live 10 lives? :) Like Reply 2y Enzo Kanawati Enzo Kanawati Allow governments to stop spending on pension 😁 Like Reply 1 Like 2y To view or add a comment, sign inTo view or add a comment, sign in

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Book Review on : LLifespan: Why We Age―and Why We Don't Have To

Lifespan: Why We Age―and Why We Don't Have To Hardcover – Illustrated, September 10, 2019 by David A. Sinclair PhD (Author), Matthew D. LaPlante (Author) 4.6 out of 5 stars 7,775 ratings Goodreads Choice Award nominee See all formats and editions Kindle $14.99 Read with Our Free App Audible Logo Audiobook $0.00 Free with your Audible trial Hardcover $15.99 92 Used from $7.79 33 New from $11.94 1 Collectible from $34.60 A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it. Read more Print length 432 pages Language English Publisher Atria Books Publication date September 10, 2019 Next page The Amazon Book ReviewThe Amazon Book Review Book recommendations, author interviews, editors' picks, and more. Read it now Frequently bought together Lifespan: Why We Age―and Why We Don't Have To+The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer+How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease Total price:$46.99 Add all three to Cart Some of these items ship sooner than the others. Show details This item: Lifespan: Why We Age―and Why We Don't Have To by David A. Sinclair PhD Hardcover $15.99 The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer by Dr. Elizabeth Blackburn Hardcover $13.99 How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease by Michael Greger M.D. FACLM Hardcover $17.01 Products related to this item Sponsored Page 1 of 157Page 1 of 157 Previous page of related Sponsored Products Never Binge Again(tm): How Thousands of People Have Stopped Overeating and Binge Eating - and Stuck to the Diet of Their Choice! 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Lifespan [Hardcover], The Telomere Effect, How Not To Die 3 Books Collection Set Lifespan [Hardcover], The Telomere Effect, How Not To Die 3 Books Collection Set Dr David A. Sinclair 4.7 out of 5 stars 101 Paperback $39.90 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Summary & Analysis of Lifespan: Why We Age—and Why We Don't Have To | A Guide to David Sinclair's Book Summary & Analysis of Lifespan: Why We Age—and Why We Don't Have To | A Guide to David Sinclair's Book SNAP Summaries 4.4 out of 5 stars 218 Paperback $6.99 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Next page Popular Highlights in this book What are popular highlights? Previous page Today, analog information is more commonly referred to as the epigenome, meaning traits that are heritable that aren’t transmitted by genetic means. Highlighted by 2,711 Kindle readers They have also evolved to require a molecule called nicotinamide adenine dinucleotide, or NAD. As we will see later, the loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old but not when we are young. Highlighted by 2,621 Kindle readers Youth → broken DNA → genome instability → disruption of DNA packaging and gene regulation (the epigenome) → loss of cell identity → cellular senescence → disease → death. Highlighted by 2,491 Kindle readers The longevity genes I work on are called “sirtuins,” named after the yeast SIR2 gene, the first one to be discovered. There are seven sirtuins in mammals, SIRT1 to SIRT7, and they are made by almost every cell in the body. Highlighted by 2,436 Kindle readers Next page Editorial Reviews Review “Lifespan is entertaining and fast-paced—a whirlwind tour of the recent past and a near future that will see 90 become the new 70. In a succession of colorfully titled chapters (‘The Demented Pianist’, ‘A Better Pill to Swallow’), Sinclair and LaPlante weave a masterful narrative of how we arrived at this crucial inflection point.” ― Nature Journal “Sinclair’s work on slowing the aging process, and even reversing some aspects of it, could lead to the most significant set of medical breakthroughs since the discovery of antibiotics nearly a century ago.” ― Sydney Morning Herald "In this insightful and provocative book that asks questions about how we age, and whether humans can overcome decay and degeneration, Sinclair grapples with some of the most fundamental questions around the science of aging. The result is an elegant and exciting book that deserves to be read broadly and deeply." -- Siddhartha Mukherjee, Pulitzer Prize–winning and #1 New York Times bestselling author “There are few books that have ever made me think about science in a fundamentally new way. David Sinclair’s book did that for me on aging. This is a book that anyone who ages must read.” -- Leroy Hood, PhD, professor at the California Institute of Technology, inventor, entrepreneur, member of all three US National Academies, and co-author of Code of Codes “If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100 plus years, then David Sinclair’s new book Lifespan, which reads like a detective novel, will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant.” -- Mark Hyman, MD, director of the Cleveland Clinic Center for Functional Medicine and #1 New York Times bestselling author “This is the most visionary book about aging I have ever read. Seize the day—and seize this book!” -- Dean Ornish, MD, founder and president of the Preventative Medicine Research Institute and New York Times bestselling author of UnDo It! “In Lifespan, David Sinclair eloquently tells us the secret everyone wants to know: how to live longer and age slower. Boldly weaving cutting-edge science with fascinating bits of history, sociology, and morality, Sinclair convinces us that it is not only possible to live beyond one hundred years, it is inevitable that we will be able to one day do so. If you are someone who wants to know how to beat aging, Lifespan is a must-read.” -- William W. Li, MD, New York Times bestselling author of Eat to Beat Disease “For years, the aging field has been about vitamins, juicebars, and snake oil. Now, in a seminal book, Harvard Professor David Sinclair has changed the landscape: he has combined precise science, practical translation, and autobiography to produce a rare book that is insightful, inspiring, and informative. He has translated a wealth of molecular detail into a program that we can all use to live longer and healthier. This is part of the ongoing revolution in aging and chronic disease, and there is no one who is better suited to write such an authoritative book than David Sinclair. For anyone interested in understanding the aging process, living longer, and avoiding the diseases of aging, this is the book to read.” -- Dale Bredesen, MD, New York Times bestselling author of The End of Alzheimer's “A visionary book from one of the most masterful longevity scientists of our time. Lifespan empowers us to change our health today while revealing a potential future when we live younger for longer.” -- Sara Gottfried, MD, New York Times bestselling author of The Hormone Cure “Prepare to have your mind blown. You are holding in your hands the precious results of decades of work, as shared by Dr. David Sinclair, the rock star of aging and human longevity.” -- Dave Asprey, founder and CEO of Bulletproof and New York Times bestselling author of The Bulletproof Diet “Imagine a world in which we can live long enough to meet not just our grandchildren, but our great-grandchildren. This is Sinclair’s vision for the future of humankind, a vision that looks to science, nature, history, and even politics to make the case that it is possible to live well into our hundreds. Lifespan is boldly leading the way.” -- Jason Fung, MD, author of The Diabetes Code and The Obesity Code “I have had the pleasure of knowing Dr. David Sinclair and following his groundbreaking research into the causes and reversal of aging for many years. In Lifespan, David takes us on an entertainingly wild ride into both the author’s fascinating personal journey of discovery and his seminal research into why we age. But more importantly, he provides us with the everyday tools that we can all use to stop what he now calls ‘the disease of aging.’. . . You owe it to yourself and your loved ones to read and follow his advice, as I have for the last 15 years!” -- Steven R Gundry, MD, New York Times bestselling author of The Longevity Paradox and medical director of the International Heart and Lung Institute “David Sinclair masterfully presents a bold vision of the future in which humanity is able to slow or reverse the aging process and live younger, healthier lives for longer. He engages the reader in a thorough examination of the science and emerging technologies that will enable humanity to achieve this vision.” -- Victor J. Dzau, MD, president of the US National Academy of Medicine and CEO of Duke University Medical Center “Lifespan is the book we have been waiting for. It transcends everything we know about aging and longevity—a combination of brilliant scientific work, a pioneering mind, and the dream for a longer, healthier and happier life. Lifespan provides a vision for our future and the roadmap on how to get there, merging scientific breakthroughs and simple lifestyle changes to not only help us feel younger, but actually become younger.” -- Naomi Whittel, New York Times bestselling author of Glow15 “I have written about the brilliant work of David Sinclair for over fifteen years and have watched his life’s mission of using science to slow the scourge of old age and dying move from the outer edge to more mainstream biology (he’s still pushing boundaries!) as his careful work in the lab has steadily shed light on how the mechanisms of aging work in humans and in other organisms. In Lifespan, the full force of his optimism, humor, and soft-spoken eloquence as a storyteller-scientist come through. I was charmed and delighted by his skill at blending his own life’s narrative and others’ with clear and levelheaded explanations of some very complex and emerging science. I’m hoping we have David Sinclair with us and doing his science and writing books for another 500 years, give or take a century.” -- David Ewing Duncan, award-winning journalist, bestselling author, and curator of Arc Fusion “Lifespan gives us hope for an extraordinary life. As the brilliant Dr. David Sinclair explains, aging is a disease, and that disease is treatable. This eye-opening book takes you to frontlines of incredible breakthroughs. What could be more valuable than an extended health lifespan? Enjoy this must read masterpiece!” -- Peter H. Diamandis, MD, New York Times bestselling author of Abundance and Bold “David is a pioneer poised to change how we think about and understand aging.” -- Stephanie Lederman, CEO of the American Federation for Aging Research (AFAR), New York “The most important message and priority of our time. For years to come, humanity will reflect on this book with awe and respect. Read it. . . . Your life depends on it.” -- Marc Hodosh, former owner & co-creator of TEDMED “A tour de force. Sinclair’s book, and his life’s work ranks with humanity’s greatest contributions to helping enhance the joy and happiness of life, ranking with the works of Jenner, Pasteur, Salk, Locke, Gandhi, and Edison. Lifespan is a groundbreaking literary triptych that expertly combines the science of living longer, a practical checklist to unleash our inner potential for healthy longevity, and a brilliant philosophical, policy and ethical synthesis. A masterpiece.” -- Martine Rothblatt, founder, Chairwoman of the Board, and CEO of United Therapeutics and creator of SiriusXM Satellite Radio “Stepping on the moon changed humanity. In Lifespan, Sinclair takes the ultimate step for humanity that will transform our lives beyond anything we could ever have imagined. If you can put your deepest beliefs aside, this will be the most important book you will ever read. The author is bold, the science is profound, and our future is here.” -- Henry Markram, PhD, professor at EPFL, Switzerland, director of the Blue Brain Project, and founder of Frontiers open-access journals “An intellectually fascinating book with tantalizing insights on the most important issue about yours and everyone’s future.” -- Andrew Scott, PhD, professor of economics at London Business School and author of The 100-Year Life “Throughout the book, the author’s enthusiasm jumps off the page.” ― Kirkus Reviews “Sinclair’s dedication to understanding aging on both a microscopic and global scale is bound to shatter centuries of paradigms.” ― Scientific Inquirer “The book, which surpasses everything we know about aging and life extension, has been written with a rich literary material of impressive depth and clarity to offer a deeper understanding of genetics and human longevity research.” ― Wall Street Pit “Brilliant and enthralling." —Wall Street Journal About the Author David Sinclair, PhD, AO, is a professor of genetics at Harvard Medical School. One of the leading innovators of his generation, he has been named by Time as “one of the 100 most influential people in the world” and top fifty most influential people in healthcare. He is a board member of the American Federation for Aging Research and has received more than thirty-five awards for his research and major scientific breakthroughs. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others. To learn more, visit LifespanBook.com and follow him on Twitter @DavidASinclair. Matthew LaPlante is an associate professor of journalistic writing at Utah State University, where he teaches news reporting and feature writing. A former US Navy intelligence specialist and Middle East war correspondent, he is the author of Superlative: The Biology of Extremes and the cowriter of multiple other books on the intersection of science and society. He lives in Salt Lake City and skis in Big Cottonwood Canyon. To learn more, visit MDLaPlante.com and follow him on Twitter @MDLaPlante. Read more Start reading Lifespan: Why We Age—and Why We Don't Have To on your Kindle in under a minute. Don't have a Kindle? Get your Kindle here, or download a FREE Kindle Reading App. Product details Publisher ‏ : ‎ Atria Books; Illustrated edition (September 10, 2019) Language ‏ : ‎ English Hardcover ‏ : ‎ 432 pages ISBN-10 ‏ : ‎ 1501191977 ISBN-13 ‏ : ‎ 978-1501191978 Item Weight ‏ : ‎ 1.35 pounds Dimensions ‏ : ‎ 6 x 1.3 x 9 inches Best Sellers Rank: #1,254 in Books (See Top 100 in Books) #2 in Genetic Health #2 in Genetics (Books) #8 in Longevity Customer Reviews: 4.6 out of 5 stars 7,775 ratings Videos Videos for this product 2:13 BOOK REVIEW: Lifespan -why we age and why we don’t have to Robert Lufkin MD Amazon Influencer Store Upload your video About the author Follow authors to get new release updates, plus improved recommendations. Follow David Sinclair David A. Sinclair, Ph.D., A.O. is one of the world’s most famous and influential scientists, known for his work on controlling the aging process. He is a tenured Professor at Harvard Medical School and TIME magazine named him “one of the 100 most influential people in the world” (2014) and among the “Top 50 People in Healthcare” (2018). His newsletter is at www.lifespanbook.com and you can follow him on Twitter @davidasinclair or IG at davidsinclairphd. He has a top healthcare podcast series called Lifespan. David is on the board of directors of the American Federation for Aging Research and has received more than thirty-five awards for his research and is an inventor on 40 patents. Dr. Sinclair has been featured on The Joe Rogan Experience, 60 Minutes, a Barbara Walters special, The Today Show, Good Morning America, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others. After thirty years of searching for truths about human biology, David is in a unique position. If you were to visit him in Boston, you’d most likely find him hanging out in his lab at Harvard Medical School, where he's a professor in the Department of Genetics and CoDirector of the Paul F. Glenn Center for Biological Mechanisms of Aging Research. He also runs a sister lab at his alma mater, the University of New South Wales in Sydney. In his labs, teams of brilliant students and PhDs have both accelerated and reversed aging in model organisms and have been responsible for some of the most cited research in the field, published in some of the world’s top scientific journals. He is also a cofounder of the journal Aging, which provides space to other scientists to publish their research on one of the most challenging and exciting questions of our time. He's also a cofounder of the Academy for Health and Lifespan Research, a group of the top twenty researchers in aging worldwide. In trying to make practical use of his discoveries, he has helped start a number of biotechnology companies and sits as chair of the scientific boards of advisers of several others. These companies work with hundreds of leading academics in scientific areas ranging from the origin of life to genomics to pharmaceuticals. He is, of course, aware of his own lab’s discoveries years before they are made public, but through these associations, he is also aware of many other transformational discoveries ahead of time, sometimes a decade ahead. Having received the equivalent of a knighthood in Australia and taken on the role of an ambassador (hence the AO at the end of his name), he's been spending quite a bit of his time briefing political and business leaders around the world about the ways our understanding of aging is changing—and what that means for humanity going forward. David is committed to turning key discoveries into medicines and technologies that help the world. He is involved in a variety of activities beyond being an academic including being a founder, equity owner, adviser, member of the board of directors, consultant, investor, collaborator with, and inventor on patents licensed to companies working to improve the human condition or national security. For an updated list of activities, see https://genetics.med.harvard.edu/sinclair/. 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Quick and easy recipes for your everyday life. 6 Paperback $14.99 Next page of related Sponsored Products Sponsored How would you rate your experience shopping for books on Amazon today? Very poor Neutral Great Customer reviews 4.6 out of 5 stars 4.6 out of 5 7,775 global ratings 5 star 74% 4 star 16% 3 star 6% 2 star 2% 1 star 2% How customer reviews and ratings work Review this product Share your thoughts with other customers Write a customer review Sponsored Reviews with images Customer imageCustomer imageCustomer imageCustomer image See all customer images Read reviews that mention david sinclair joe rogan must read well written longer and healthier cutting edge highly recommend aging as a disease great book life changing anti aging years ago healthy life global warming health span amino acids second half aging process subject matter eye opening Top reviews Top reviews Top reviews from the United States R. Cronise 5.0 out of 5 stars He changed my life. Let him change yours. Reviewed in the United States on September 15, 2019 Verified Purchase As one of the pioneers in longevity research, David challenged status quo and demonstrated that nature’s longevity genes seemed to be conserved throughout biology. This is good news, because the changes that occur with aging seem to be correctable later in life. This isn’t another self-help book with meal plans and shopping lists. Instead, it will guide you through the real challenges and progress on our path to not just living longer, but importantly, living healthier. Although this is plenty technical, it’s not an academic tome. Anyone, researcher or layman alike, will be able to follow the story thanks to the inclusion of so many personal accounts and reflections. After finishing, you will have a new perspective and hopefully realize that we have the ability right now to extend healthspan and the very real possibility of extending lifespan in the coming decade. We met in 2009 and he encouraged me to write collaborative journal articles (metabolic winter hypothesis and oxidative priority) and now that work ultimately is the basis for our book, The Healthspan Solution, which focuses more on what we can achieve with diet. It’s been an honor working with him and having a man of his insight as a mentor and friend. Customer imageCustomer image 361 people found this helpful Helpful Report abuse Timothy D. Lundeen 5.0 out of 5 stars All about healthy life extension, by a leading scientist Reviewed in the United States on September 17, 2019 Verified Purchase . David makes three critical points: * longer healthy lifespan improves all of our lives, not just personally, but for all of the people we love * mechanisms to increase lifespan are part of our cells and often just need to be activated * increasing healthy lifespan will not make the world overcrowded, but will benefit everyone by increasing productivity and overall well-being All of these are well-supported and convincing, including touching and memorable personal experiences. I do have one major issue, though. Our current medical system is focused on the bottom line, making money is more important than the best protocol. Look at Vioxx, for example, which killed thousands of people so that Merck could make more money. David has personal experiences with the system: his Mom almost died from poisoning by prescription medicine, and his daughter could have died from a serious Lyme infection that was not properly handled. Yet David accepts that vaccination is a medical miracle, without doing any research on its risks and benefits. I hope he will take a serious look at all the issues: * the extremely high rates of chronic illness in vaccinated vs non-vaccinated children, The Children’s Health Defense has a good series based on peer-reviewed research * the connection between aluminum and autism, with artists having the highest levels. See Dr Chris Exley’s peer-reviewed work. Most vaccines have high levels of aluminum that has been shown to stay in the body and migrate to the brain * the connection between vaccination-induced brain inflammation and brain injury, see vaccine papers dot org, which includes full-text copies of peer-reviewed research: "powerful scientific evidence has emerged indicating that vaccines cause brain injury such as autism, epilepsy, schizophrenia, depression, attention-deficit disorder and other mental illnesses. This scientific evidence has been largely ignored by the media, and by medical institutions that are supposedly guided by science." * the actual history of vaccination. Medical historians estimate that ALL of modern medicine, including vaccination and antibiotics, reduced childhood mortality by 4-6%. That is, 94-96% of the reduction was from improved sanitation and nutrition. For example, scarlet fever has been eradicated — without any vaccine. A good source is the book Dissolving Illusions. * the actual contents of vaccines as analyzed by Corvelva, showing high levels of contamination * the lack of liability for vaccines by the medical industry. Instead, a government fund compensates injuries, and has paid out over $4 billion. This does not motivate safer vaccines! Read more 320 people found this helpful Helpful Report abuse Kindle Customer 3.0 out of 5 stars Meh - not much actionable except for a single page Reviewed in the United States on October 3, 2019 Verified Purchase Dr. Sinclair has been doing the podcast rounds and you can learn a lot more from those podcasts about his research than you can from this book. The book itself is full of anecdotes and socio-political-economic idea;, it might be useful as an introduction for those flirting with the idea of life extension, but this book isn't for those who are already interested in it. There's one page in the "Conclusion" section where he mentions what he does which is a 1g NMN, 1g resveratrol, Vitamin D, K2, 83mg aspirin, avoid sugar, bread, pasta, skip one meal a day, get your blood tested, don't smoke, avoid plastic, excessive UV exposure, X-Rays, CT scans, sleep in a cold bedroom, do cold exposure, do exercise. 2,495 people found this helpful Helpful Report abuse Ben 5.0 out of 5 stars One of the most important books ever written Reviewed in the United States on September 12, 2019 Verified Purchase I've been following Dr Sinclair for some time and have always been impressed by his ability to explain the most complex science to us commoners. But I didn't truly grasp the breadth of different science he is involved in until now. The breakthroughs they are making now is astounding, and the speed they are occuring is dramatic. But that is just the tip of the iceberg once he (and others) convince the policy makers to treat aging as a disease and fund the research. It has the potential to stop nearly all chronic disease, so the efforts should be increased 1000x times, or more. I believe this will happen soon, and this book may be a significant factor in the dawning of a new era for humankind. Dr Sinclair is a visionary with the ability to truly change the world. 180 people found this helpful Helpful Report abuse T. S 4.0 out of 5 stars Useful, if you know a bit of cell biology Reviewed in the United States on September 11, 2019 Verified Purchase I am reading and am continuing to read. This book is important. But one would need a basic education in cell biology to completely understand what the author is talking about. Page 5 has a couple of paragraphs where out of nowhere, the author starts talking about “DNA, gene, genetic material, cell division, chromosome, tumor”. If you have no clue what these are, you will have a hard time following the author. If you are like me (software engineer) I would urge you to learn about basic cell biology first and then read this book to fully appreciate it. If I were the author, I would definitely look at providing an introductory chapter on cell biology in the next edition (if the intended audience is lay people) 243 people found this helpful Helpful Report abuse David Weiseth 5.0 out of 5 stars One of the preeminent thought leaders in this space, ie longevity Reviewed in the United States on September 13, 2019 Verified Purchase I have two gurus I rely on for longevity advice, Sinclair and Longo, they actually offer two different approaches to the subject matter, but between the two you have a great lay of the land. This book is highly recommended, I am reading it now, very slowly to glean all I can, I have been waiting for this book's release for 6 months, finally the day has arrived. 102 people found this helpful Helpful Report abuse See all reviews Top reviews from other countries Honest Reviewer 3.0 out of 5 stars A book of two halves: the first part fascinating, the second... Reviewed in the United Kingdom on November 2, 2019 Verified Purchase Although the book is split into three sections - the past, the present and the future - it reads as two halves: what is essentially scientific and what is decidedly ethical. When Dr Sinclair confines himself to his subject, it very difficult to put the book down. He discusses the advances in genomics, etc, that led him and others to studying ageing, before discussing current research and the notion that ageing is more a disease than a natural process. He includes some scientific detail, a few useful analogies and a good smattering of anecdotes to impress and educate the reader, which, despite some obvious padding, he undeniably does. I think a typical scientist would and should stop right there; for science does not concern itself with morality but with pure knowledge whether constructive or destructive. Nonetheless, Dr Sinclair goes on to debate the real and political consequences of people living, if not forever, certainly much longer than they do now. To me, this is where the book rapidly goes down hill. Dr Sinclair knows there will be serious repercussions: an increase in population; a greater demand for resources; more pollution; more carbon emissions; etc, etc. He says that alongside the big increase in population in the 1800's was a huge increase in the standard of sanitation and health as though it were causative - more people lead to more benefits. He thinks that GMO and foods modified by other technologies will provide the solution to feeding the ever-increasing numbers of mouths and gets irritated when some people have the temerity to question their safety. Also, because he would be content to work doing his interesting research in his lab for the next 50 years, it does not mean a miner would like to spend another 50 digging coal. Despite Dr Sinclair's faith in the ingenuity of man, there are times when i sense he is trying to convince himself of his utopian vision rather than the reader. Living to infinity is not the be all and end all; living a healthy life is more important, whether one lives to 70 or 90. At some point I will re-read the first half of the book - which I enjoyed - but not the second. I must be only part Luddite. Read more 187 people found this helpful Report abuse Thomas Burgess 3.0 out of 5 stars Interesting. Not sure of the ethics. Reviewed in the United Kingdom on December 22, 2019 Verified Purchase Very interesting book. Destroys the paradigm that aging is natural and opens your mind to it being a disease (basically a failure in our genes.) Richard Dawkins touched on why we would inherit genes that fail as we age: essentially we reproduce before we suffer from these age-related ailments, and so natural selection has not filtered it out as it presumably has young man/woman ailments that would kill off the would-be reproducer. The book uses scientific terms and explanations and so some reading on physiology may be beneficial alongside this book. Note taking is a must if you're wanting to retain and be able to explain the contents. The reason I've given it 3 out of 5 stars is the completely lack of concern over the animals the author and his colleagues tested on. I know its commonplace (though this doesn't make it right) but there is not even any acknowledgement from the author that this is cruel behaviour. He will talk about how he'll age mice prematurely (yes fascinating but cruel), starve them, dissect them prior to natural death, etc. He does comment on how easy it is to buy mice to test on, though. Well, as long as subjecting unlucky animals to torture is convenient! Read more 150 people found this helpful Report abuse CI 5.0 out of 5 stars Fabulous! Reviewed in the United Kingdom on September 22, 2019 Verified Purchase Great book. Really interesting. Gives a glimpse of the future in terms of cutting edge gene therapy but also provides advice that anyone can implement now e.g. fasting, exercise, calorie restriction and certain supplements. Highly recommended. 45 people found this helpful Report abuse Stan 5.0 out of 5 stars Must read book Reviewed in the United Kingdom on September 20, 2019 Verified Purchase I am reading this book while traveling. It is better than I expected and deeply personal from David. I already know many of the topics the book is talking about but I find it very useful to consolidate my knowlege. The knowledge in this book is of enormous value and at the same time the book is low cost. I think it is the most important book I read this year. 32 people found this helpful Report abuse Lindsay Tideswell 5.0 out of 5 stars Thought provoking read Reviewed in the United Kingdom on October 15, 2019 Verified Purchase For someone who is not a Scientist or indeed aware of any of the issues in the book, this book is a must read if you are in the slightest bit interested in enjoying this wonderful life for as long as possible. It has certainly opened up my mind to what is possible and encourages you to look at our human bodies in a totally different way. I guess for experts a lot of the information is 'old hat' for me it proved to be the springboard to find out as much as I can about living longer and healthier. I hope to be a very well informed layman in 6 months time able to make some key decisions. Outstanding read. 31 people found this helpful Report abuse See all reviews Customers who bought this item also boughtPage 1 of 9Page 1 of 9 Previous page The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer Dr. Elizabeth Blackburn 4.5 out of 5 stars 1,246 Hardcover $13.99 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Only 1 left in stock - order soon. 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Sinclair 4.7 out of 5 stars 101 Paperback $39.90 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Why We Sleep: Unlocking the Power of Sleep and Dreams Why We Sleep: Unlocking the Power of Sleep and Dreams Matthew Walker 4.7 out of 5 stars 18,906 Paperback $10.29 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon NMN Nicotinamide Mononucleotide Supplements 250mg - Stabilized Form (60 Capsules), 99% Pure NMN Supplement Capsules for Incre NMN Nicotinamide Mononucleotide Supplements 250mg - Stabilized Form (60 Capsules), 99% Pure NMN Supplement Capsules for Increased NAD Levels, DNA Repair, & Healthy Aging, GMP Certified, Genex Formulas 4.4 out of 5 stars 1,438 Amazon's Choice in Vitamin B3 (Niacin) Supplements $41.50 ($0.69/Count) Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Mimic Fasting Recipes: The Fasting Mimicking Diet (FMD): Meal Plan + Fasting Guide. Over 30 Recipes and Exact Doses Mimic Fasting Recipes: The Fasting Mimicking Diet (FMD): Meal Plan + Fasting Guide. Over 30 Recipes and Exact Doses FIVE FRIENDS FOR FASTING 4.0 out of 5 stars 27 Paperback $19.97 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Lifespan Why We Age and Why We Don’t Have To By Dr David A. Sinclair and 12 Rules for Life An Antidote to Chaos By Jordan B. Lifespan Why We Age and Why We Don’t Have To By Dr David A. Sinclair and 12 Rules for Life An Antidote to Chaos By Jordan B. Peterson 2 books Collection Set Dr David A. Sinclair 4.4 out of 5 stars 47 Paperback $21.70 Lifespan - David Sinclair, PhD (overview & thoughts) 15,935 viewsDec 28, 2019 The Sheekey Science Show 28.2K subscribers I recently read "Lifespan - Why We Age - and Why We Don't Have To" by David A.Sinclair PhD, so I have made a video summarising the key messages from the book and also my thoughts and opinions on it! It was hard to summarise everything in 12 mins without revealing too much from the book, so you should go buy and read the book for yourself! https://amzn.to/39ifQil Is Calorie restriction legit - https://youtu.be/0rH9fKukyGo Eric Topol - Deep Medicine (REVIEW) - https://youtu.be/B9VWNIzCJ5k Featured playlist 58 videos Hallmarks of aging The Sheekey Science Show 42 Comments rongmaw lin Add a comment... Dora The Illegal Alien Pinned by The Sheekey Science Show Dora The Illegal Alien 2 years ago you need a hell of a lot more subscribers and views 17 The Sheekey Science Show Robert Scott Robert Scott 1 year ago Dear Sheeky , I enjoyed Sinclair's book very much and your review is helpful. Sinclair is a serious researcher who has devoted his career to understanding the biology of ageing. But after reading Andrew J Steele's book "Ageless" and delving into the literature, partly with the help of your channel, I find Sinclair's perspective rather narrow. He claims to have found the theory of ageing, yet other researchers in the field seem to tell a more complicated story. The 2013 review article by Lopez-Otin et al., seems to be quite influential with over 7000 citations on Google scholar. They cite 9 halmarks of ageing, one of which is epigenetic alterations and seems to include Sinclair's work on sirtuins. In other words, perhaps epigenetics is important to ageing but there is much more too it. For example, one might ask how are pathways involving sirtuins going to help us live longer if we die of a heart attack or stroke because of increased blood pressure because the artery walls lost the flexibility to expand? 3 אנחנו מדברים פודקאסט אנחנו מדברים פודקאסט 7 months ago (edited) 1:30 Your cells getting old is like a cd which is new getting more and more scratched till it's not useable 3:30 Caloric restriction helps live longer 7:00 MMN is great drug 8:00 Exercise more. 8:1/ Go out the termonetural zone. Do cold shower Go outside when it's cold. Do sauna 10:30 Interesting 12:13 Old age is a diesase 3 Hollywoodiani it Hollywoodiani it 1 year ago Hi Eleanor! May I suggest you to read the book "Cracking the aging code" that presents a very original theory of aging that I found very compelling. It is not much about the biochemical mechanisms but more about the evolutionary underpinnings. That could be another video idea... 2 The Sheekey Science Show Deika Elmi Deika Elmi 2 years ago I loved this, you broke it down and made it easy to understand. Thank you! 5 The Sheekey Science Show G3orgianSoldier G3orgianSoldier 1 year ago I am a mathematician and have just made a presentation about Claude Shannon's works in my university. It's so cool to see it here :D 2 The Sheekey Science Show Jay Ahn Jay Ahn 1 year ago Thank you very much for the concise and artistic presentation. I liked also your English accent. 7 The Sheekey Science Show Intaek Kim Intaek Kim 1 year ago I bought the book and read the first part of it. Your concise video is very helpful in summarizing the book. Thank you! 1 The Sheekey Science Show bjorn2fly bjorn2fly 2 years ago Nice video, still a problem with the microphone, but better than last video. Also In many countries Metformin is without prescription. Also loved your last video on aging, pity you dont get a bigger audience here on youtube, but maybe you can live forever, now that you know so much about reversing ageing :-) 3 Scott Herford Scott Herford 2 years ago Thanks Sheeky, Lifespan is jampacked but really fascinating reading. 3 The Sheekey Science Show Larry Kraft Larry Kraft 1 year ago I’ve recently come across your channel and I’ve greatly enjoyed several of your videos. Thank you very much for the energy and time you have put into A, getting so smart and B, making such important information accessible to the rest of us! If I may make one suggestion (and please excuse me if you’ve already adopted this in later videos), could you please add like a 2 second pause whenever you get done building an image before jumping to a new image? For example, at about 4:45 in this video I had a hard time discovering what the final E in that acrostic was for. I finally had to slow it down to 1/4 speed to see that the final E in CALERIE (sic) was for “energy.” I look forward to watching your video on calorie restriction. For a good laugh take any speech from anyone and slow it to 1/4 normal speed. It makes them sound like they’re half asleep. Thanks again! The Sheekey Science Show Yusun Liu Yusun Liu 1 year ago After listening to your several videos, my eyes can not stop following your sketching and writing. 1 The Sheekey Science Show Katie Scarlett Katie Scarlett 9 months ago (edited) Great review! Who was the scientist that came up with the Free Radical Theory of Aging? Each copy of the cell that is made after the Free Radical Damage has been done, is like a bad xerox copy till the original is very different from the copy. Inflammation is the same premise. Then the activation of the SIRT 1 Gene has been something that has been discussed in the past as well. Mitochondrial has not been addressed by anyone except physicians active in Chronic Fatigue Syndrome. So that would be interesting. Emmanuel Trejo Emmanuel Trejo 1 year ago Excellent, thank you very much 1 The Sheekey Science Show Aetheral Passenger Aetheral Passenger 5 months ago Omg thank you for this again. I didnt have the time to read all of it. Subbed! The Path of Eudaimonia The Path of Eudaimonia 6 months ago Searching for "Lifespan summaries" got me here, and I am so happy for finding your channel! The Sheekey Science Show Pickaxing on Europa ! Pickaxing on Europa ! 3 months ago These book reviews keep getting better and better. 🐳 Zombie Prodigy Zombie Prodigy 1 year ago (edited) I have a question! :) He claims that we need to put our body into "stress modes", to activate our sirtuins, and that by doing so, they will help repair damage caused by "epigenetic noise." The thing Im not understanding is that he says sirtuins going back in the wrong spots sometimes and slicing genes not meant to be sliced, is what causes aging. So why on Earth would we ever want to send out more sirtuins??? Maybe I'm confused here, but why is moderation good? I know it is, but why is almost all activity not harmful?? Say even weight lifting, where you tear your muscles to build new ones. He says that fine, but why?? Would that not causes sirtuins to repair and then maybe go back into the wrong places??? Thanks so much for helping! :) 1 Yavuz Bahadır Taktak Yavuz Bahadır Taktak 7 months ago nice and precise. here is a thing: if scientists manage to achieve prolongation of life and if it will be accessible to anyone, human population will exponentially grow (do we have enough energy to keep growing and keep nature clean :P); if it stays as a privilege in rich guys' hands as Harari mentioned we are creating superhuman beings. Maicon Moraes Maicon Moraes 1 year ago NICE! I'm surely going to buy it 1 The Sheekey Science Show Chewing The Fat Chewing The Fat 1 year ago For the resveratrol side, the issue is with bio availability. And wine and absorbing through the lining of the mouth is the most bio available process. And while true as to the amount of wine required to be effective, dr Phil Norrie has developed “the wine doctor” wine and resalixer. So in the case of the resilixer, you take 50ml and rinse around your mouth for a few min and it’s the equivalent resveratrol to 10 bottles of red wine. While the bottle of wine doctor wine contains the equivalent resveratrol to 20bottles of red wine. Feel free to contact for more info Christopher Ellis Christopher Ellis 1 year ago (edited) I'm reading the Romanian edition. (The editor cannot decide whether it's Sydney or " Sidney. The Spaniards are similar confused" The FDA is an American problem. Kira Senna Kira Senna 1 year ago is a hot shower also considered a thermoneutral zone? i would prefer this over a cold shower though J z J z 2 years ago Thanks! 1 The Sheekey Science Show walterjab walterjab 2 years ago Nice, thank you. 1 The Sheekey Science Show Gio Gio 2 years ago Nice video and work 1 The Sheekey Science Show Buzz231094 Buzz231094 1 year ago This was interesting The Sheekey Science Show Ahmet Dizioglu Ahmet Dizioglu 2 years ago Thanks 1 The Sheekey Science Show shivam vaidya shivam vaidya 2 years ago Audio is very bad 2 Ed Mylett 634K subscribers Most of us want to live as long as possible. It’s a SURVIVAL INSTINCT that’s hard-wired into our DNA. BUT IT’S NOT ENOUGH TO LIVE A LONG LIFE. OUR QUALITY OF LIFE MATTERS, TOO. Unlocking the secrets to a long, healthy life has CHALLENGED MANKIND since the dawn of medical science. Those of you who know me, also know I’ve been fascinated by this subject for quite a while, too. That’s why it’s a great privilege to welcome back this week’s guest, DR. DAVID SINCLAIR. He is a LEADING SCHOLAR and Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at HARVARD MEDICAL SCHOOL where he has been teaching aging biology and translational medicine for aging for the past 16 years. More than that, he is also a foremost researcher best known for his work on UNDERSTANDING WHY WE AGE and HOW TO SLOW ITS EFFECTS. Contemporary BLEEDING EDGE RESEARCH and scientific advancements have propelled us forward and not only UNLOCKED SECRETS TO LONGEVITY but have also created new questions and curiosities that continue to excite our BEST AND BRIGHTEST MINDS. And few people on planet earth are as well versed or as educated on this subject as Dr. Sinclair. He lives in a world filled with deep examinations of hormesis, sirtuins, energy metabolism, biosynthesis, mTOR levels, reprogramming genes, mitochondria, learning and memory, time-restricted feeding and caloric restrictions, neurodegeneration, and cancer. While many of you may AWESTRUCK by this area of science, you should also be EXCITED by Dr. Sinclair’s research, because one day it will have a DIRECT IMPACT on you. This week, we’re going to translate what that research means to you in practical terms…and it’s coming sooner than you think! Dr. Sinclair covers a wide range of topics from red light therapy, to the effects of glucose on our bodies, hormone replacement, and the importance of being physically active, fasting, and not eating meat. We also touch on ALTERING DNA which holds the possibility of significantly extending life, and CURING HORRIFIC DISEASES like cancer, MS, Alzheimer’s, Parkinsons, and many others. Our discussion isn’t just about theories and research though. Dr. Sinclair has also got some HANDS-ON TIPS on what you can do to start to start feeling and looking younger right now. So, sit back, relax, and LEARN. CLASS IS ABOUT TO BEGIN, and I guarantee, you won’t want to miss it. 0:00 Intro 1:25 Are we actually younger if we look younger? 2:23 The basis of hormesis 5:01 Effects of time-restricted feeding 8:34 What are mTOR levels? 11:01 David's thoughts on physically active people fasting & not eating meat 15:59 Effects of glucose in our body 21:29 David's thoughts on red light therapy 25:06 How is age measured today? 29:39 David's thoughts on hormone replacement 36:04 Low levels of growth hormone make you live longer 38:58 David's thoughts on NAD 42:21 How Metformin affects glucose in our body 46:13 What is MOTS-c? 47:58 Where are we today in terms of being able to alter DNA? 52:02 What's David most excited about his work right now? 1:38:00 Is there a negative to people living so much longer? 1:02:58 Is there anything that worries David? 1:04:26 Other things that can extend or better your quality of life #DavidSinclair #reverseaging #antiaging #antiagingtips #antiagingfoods #antiagingtreatment #hormonereplacementtherapy #redlighttherapybenefits ---- Thank you for watching this video—Please Share it and get the word out! What part of this video resonated with you the most? Comment below! 👇 SUBSCRIBE TO ED'S YOUTUBE CHANNEL NOW 👇 https://www.youtube.com/channel/UCIpr... ---- Let's MAXOUT! Send me a text message at 714-916-9144 to receive weekly updates when new episodes are available! ---- → → → CONNECT WITH ED MYLETT ON SOCIAL MEDIA: ← ← ← → → → CONNECT WITH ED MYLETT ON SOCIAL MEDIA: ← ← ← ▶︎ YOUTUBE | https://www.youtube.com/edmylett ▶︎ INSTAGRAM | https://www.instagram.com/edmylett ▶︎ FACEBOOK | https://www.facebook.com/EdMylettFanPage ▶︎ LINKEDIN | https://www.linkedin.com/Edmylett ▶︎ TWITTER | https://www.twitter.com/edmylett ▶︎ WEBSITE | https://www.EdMylett.com ---- #EdMylett #Motivation Chapters 501 Comments rongmaw lin Add a comment... Steve S Steve S 5 months ago Aging is a profoundly negative process. This interview causes optimism to soar! Dr Sinclair: please hurry, I'm older than you but trying just as hard to stay youthful. Intelligent interview. 42 Diane Hansen Diane Hansen 4 months ago Ed is a great host!! He is humble, intelligent, and asks important questions. David Sinclair is the man! He's so knowledgeable, humble, and clear. Thank you both for a first rate podcast!! 33 Richard Lock Richard Lock 5 months ago I’ve been following David Sinclair for a while and doing intermittent fasting for the last 9 months because of his advice. I’ve never felt consistently healthier! Cheers for putting this together, Ed! 129 The Ancients Ancients The Ancients Ancients 4 months ago I'm surprised at how Sinclair who was written off over a decade ago has some revival again by people newly interested in this subject ! Most serious experienced cellular aging experts dismiss him with his vague science 7 Mary Fitzgerald Mary Fitzgerald 4 months ago This is the best interview I have heard to date about anti-aging, age reversal techniques currently available and what to expect in the future. I had to share it with my friends. 4 Evan Carmichael Evan Carmichael 5 months ago What an episode. Ed + David is pure fire!! :) #Believe 30 The Calming Gourmet The Calming Gourmet 4 months ago Re: diet, something interesting with 23&me, you can download your genetic weaknesses and put it in a program to learn, among other things, what foods to focus on with relation to your genetic weaknesses. Approx. 80% were animal-based food suggestions, not plant based. Find out what's right for you and create your own wellness journey. Certainly learn from others, but each of us are different, including Dr. Sinclair. 🌼 4 Jessica Terry Schneider Jessica Terry Schneider 4 months ago Incredible!! So grateful to have people like you Sinclair for diving into this industry and Ed for the platform and using it to share some amazing content. 👏 11 Monica Brante Monica Brante 4 months ago (edited) This is SO good! Thank you for sharing. - It is a lot and I need to listen to this a few times, but I feel that it is all here, which is great! Love it when he comments on how woman also benefits... there is very little research done on the female body, fasting etc. 5 J E J E 5 months ago This episode was suggested to me by a friend, great interview questions and an amazing episode. You have a life long listener now. Thanks for the actually useful content 10 Shuli Bitton שולי ביטון Shuli Bitton שולי ביטון 5 months ago I'm so looking forward to this interview! I still remember the previous one which was super fantastic and I learned so much new information I had never heard of! He definitely looks younger since the last interview which reminds me of the movie Benjamin Button. We want the body not to become complacent, to put the body in perceived adversity as opposed to an abundance state.I agree that preventative medicine is so much better than treating symptoms after you get ill.I've been doing time restricted eating for many years now. I eat two meals a day without snacking and never eat breakfast. Moderation is the key to everything in life. I can't wait for my daily walk to listen to this entire episode #MAXOUT from Israel 32 Peter Horak Peter Horak 5 months ago I’m blown away by the information that David has shared about the latest status of anti-aging science. Absolutely incredible what has already been achieved. I had no idea we are so close to some incredible medical treatments that could literally reverse our aging clock ! Great interview Ed 🙏👊 34 Lessons in 30s Lessons in 30s 5 months ago For the 1% of people reading this, I hope you become successful in your life! 33 LittleOne3179 LittleOne3179 5 months ago (edited) I’m curious as to when inside tracker will include estrogen and other female hormones in their bio markers. I am 59 years old and a powerlifter, my inner age scored 9yrs younger than my biological age. My testosterone levels were even optimal, however the SHBG levels are an issue and I am sure not allowing me to optimize the testosterone I have. I sincerely hope more female hormones will be included someday? What can we do naturally to increase estrogen levels ? I’m currently investigating this and would love your thoughts. Menopause isn’t healthy for any woman and affects aging. Thank you for all you do! 9 benjiebarker benjiebarker 5 months ago Dr Sinclair’s resveratol and NMN regimen is helping my mom’s alzheimers…i think reversing aging is helping her Alzheimer’s 7 Life is wonderful Bao Life is wonderful Bao 5 months ago 13) metformirn therapy can help you 14) nmn therapy protecte against aging 15) Mot C 16) crispers (changing gene) while fixing genes 18 Sonya Sun Heart Sonya Sun Heart 4 months ago (edited) It's happening!! When i gave birth to my daughter at 41 , my biological age was 27 years old ! I love learning about this topic; thank you so much for this talk - I'm 48 yrs young and never felt better ! 😁🙏 13 JULES22 JULES22 4 months ago My great great aunt is 105 yrs ,,, still bakes and walks everyday, takes no medication, takes ensure for past 30 yrs, had her memory and no health problems,,,,, eats what she wants,,, no alcohol, no cigarettes, no drugs,,, big family,,,,, believes in god 2 Grant Burris Grant Burris 3 months ago Well done! I follow all David Sinclair's talks. I am grateful for the work he does and his willingness to explain it. I greatly enjoyed the host and how he managed the questions. Great! 1 Richard Sheridan Richard Sheridan 1 month ago (edited) Ed and David, I literally stumbled on this interview at 1am in the morning. I've been slowly learning about the various components to combat aging from Dr. Sinclair and it's been daunting. This interview is the single most information power packed episode I have ever seen in almost two years of watching/listening. This is as close to a true personal road map as I have ever had and I am Dr. Sinclair's age. My dream is to be able to care for my aging parents in their 80's and like Ed, I too have chills going up my spine with excitement about what is in the near term future. What research has done and simple things that we people can do, simple choices we can make to extend both lifespan and healthspan. Thank you so much for this interview, I am hopeful, inspired and excited. 1 Yawa huang Yawa huang 4 months ago I really like dr David podcast ! My parents and my only sister are all have high blood pressure. I am only one don’t it☺️ I am 56 years old woman and I have 0 chronic disease- I have been always eating whole foods, always listen to my body ❣️ 1 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon