Sirtuin, Silent Mating Type Information Regulator 2-like Proteins

Sirtuins MeSH Descriptor Data 2022 Details Qualifiers MeSH Tree Structures Concepts MeSH Heading Sirtuins Tree Number(s) D08.811.277.087.520.200.650 D08.811.913.400.725.115.961 D12.776.476.900 Unique ID D037761 RDF Unique Identifier http://id.nlm.nih.gov/mesh/D037761 Scope Note A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities. Entry Term(s) SIRT SIRTs Silent Mating Type Information Regulator 2-like Proteins Sir2-like Proteins Sirtuin Registry Number EC 3.5.1.- Previous Indexing Histone Deacetylase (2000-2002) See Also Silent Information Regulator Proteins, Saccharomyces cerevisiae Public MeSH Note 2003 History Note 2003 Date Established 2003/01/01 Date of Entry 2002/07/03 Revision Date 2020/05/27 page delivered in 0.186s Connect with NLM Twitter Facebook You Tube National Library of Medicine 8600 Rockville Pike Bethesda, MD 20894 Web Policies FOIA HHS Vulnerability Disclosure NLM Support Center Accessibility Careers