Morgan Levine, PhD, on PhenoAge and the Epigenetics of Age Acceleration

12:15 / 1:20:53 #Aging #TrueAge Morgan Levine, PhD, on PhenoAge and the Epigenetics of Age Acceleration — can we change the pace? 59,143 viewsPremiered Apr 12, 2022 FoundMyFitness 424K subscribers Morgan Levine, Ph.D., developed the phenotypic aging clock called PhenoAge and is a Founding Principal Investigator at Altos Labs, a biotech company that seeks to understand the mechanisms that drive the aging process and age-related diseases with the hope of identifying possible interventions. Additionally, Dr. Levine is an assistant professor of pathology at the Yale University School of Medicine, where her research focuses on the science of biological aging. Dr. Levine completed a postdoctoral fellowship with previous guest Dr. Steve Horvath, a pioneer in the field of epigenetic clocks. Show notes and transcript available: https://www.foundmyfitness.com/episod... Pre-order Dr. Morgan Levine's new book True Age: https://www.amazon.com/True-Age-Cutti... CHAPTERS: 00:01:19 - What is aging? 00:03:20 - Why biological aging matters to scientists 00:04:45 - Hallmarks of aging 00:05:24 - What are the drivers of aging? 00:06:58 - What CpG methylation says about aging 00:08:59 - The advantage of epigenetic clocks in research 00:10:12 - New generation epigenetic clocks: GrimAge and PhenoAge 00:11:51 - Clinical biomarkers vs. epigenetic clocks 00:12:50 - Differences in aging between organ systems 00:16:47 - Do some people age faster than others? 00:19:05 - Epigenetic age acceleration 00:20:39 - Is age acceleration a genetic risk inherited from your parents? 00:22:27 - The effects of menopause on aging 00:23:16 - Does the pace of epigenetic aging change throughout life? 00:24:39 - How does obesity and human disease affect epigenetic aging? 00:26:12 - Why genes from development may be key to understanding aging 00:27:13 - Determining epigenetic age in non-human mammals (all of them) 00:27:50 - Is aging an accident of evolution or by design? (See also 00:48:20) 00:30:17 - What happens to the epigenetic age of immortal cells if you grow them forever? 00:31:40 - Effects of cancer treatment on epigenetic age 00:35:43 - Severe COVID-19 and accelerated epigenetic 00:36:40 - Are epigenetic changes in aging a cause or consequence? 00:39:23 - Are the CpG sites used by epigenetic clocks functionally meaningful? 00:42:15 - Reversing epigenetic age with interrupted reprogramming techniques 00:49:27 - Therapeutic plasma exchange in aging and pro-geronic blood factors 00:53:23 - The effects of neutral plasma exchange on the brain 00:56:01 - Lifestyle factors that accelerate epigenetic age 00:57:56 - The aging acceleration effect of smoking 00:59:37 - Omega-3 hypermethylation of inflammatory pathways 01:03:23 - Reliability of consumer epigenetic clock tests 01:06:12 - Construct validity of epigenetic clocks 01:12:06 - Thoughts on most exciting research in aging field 01:13:44 - Dr. Morgan Levine's lifestyle habits 01:15:00 - Intermittent fasting effects on epigenetic age Dr. Morgan Levine on Instagram: https://www.instagram.com/dr.morganle... Dr. Morgan Levine on Twitter: https://www.twitter.com/drmorganlevine Dr. Rhonda Patrick on Instagram: https://www.instagram.com/foundmyfitness Dr. Rhonda Patrick on Twitter: https://www.twitter.com/foundmyfitness SUBSCRIBE TO THE FOUNDMYFITNESS YOUTUBE CHANNEL: https://www.youtube.com/user/FoundMyF... Get notified of new videos by hitting the bell icon. This episode is available as a podcast on Apple Podcasts and Spotify: https://podcasts.apple.com/us/podcast... Listen to FoundMyFitness on Spotify: https://open.spotify.com/show/5QjpaU0... Premium subscribers of FoundMyFitness get access to a Google Presentation for the graphics in videos, earlier access, a two-times-per-month science news digest and commentary, and some kind of live online event usually every month. Learn more at: https://www.foundmyfitness.com/crowds... #Aging #EpigeneticClocks #TrueAge 149 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 2 months ago (edited) Find Dr. Levine's new book True Age on Amazon! If you enjoy the material we produce, please consider liking, sharing, and subscribing with notifications. We develop the extra resources provided with each episode through the support of our premium members. Learn how to get exclusive bonus content and other added perks here: https://www.foundmyfitness.com/crowdsponsor True Age: Cutting-Edge Research to Help Turn Back the Clock." You can pre-order it on Amazon now: https://www.amazon.com/True-Age-Cutting-Edge-Research-Clock/dp/0593329287 18 Cheryl R Leigh Cheryl R Leigh 2 months ago CHAPTERS: (from Dr. Patrick's description box) 00:01:19 - What is aging? 00:03:20 - Why biological aging matters to scientists 00:04:45 - Hallmarks of aging 00:05:24 - What are the drivers of aging? 00:06:58 - What CpG methylation says about aging 00:08:59 - The advantage of epigenetic clocks in research 00:10:12 - New generation epigenetic clocks: GrimAge and PhenoAge 00:11:51 - Clinical biomarkers vs. epigenetic clocks 00:12:50 - Differences in aging between organ systems 00:16:47 - Do some people age faster than others? 00:19:05 - Epigenetic age acceleration 00:20:39 - Is age acceleration a genetic risk inherited from your parents? 00:22:27 - The effects of menopause on aging 00:23:16 - Does the pace of epigenetic aging change throughout life? 00:24:39 - How does obesity and human disease affect epigenetic aging? 00:26:12 - Why genes from development may be key to understanding aging 00:27:13 - Determining epigenetic age in non-human mammals (all of them) 00:27:50 - Is aging an accident of evolution or by design? (See also 00:48:20) 00:30:17 - What happens to the epigenetic age of immortal cells if you grow them forever? 00:31:40 - Effects of cancer treatment on epigenetic age 00:35:43 - Severe COVID-19 and accelerated epigenetic 00:36:40 - Are epigenetic changes in aging a cause or consequence? 00:39:23 - Are the CpG sites used by epigenetic clocks functionally meaningful? 00:42:15 - Reversing epigenetic age with interrupted reprogramming techniques 00:49:27 - Therapeutic plasma exchange in aging and pro-geronic blood factors 00:53:23 - The effects of neutral plasma exchange on the brain 00:56:01 - Lifestyle factors that accelerate epigenetic age 00:57:56 - The aging acceleration effect of smoking 00:59:37 - Omega-3 hypermethylation of inflammatory pathways 01:03:23 - Reliability of consumer epigenetic clock tests 01:06:12 - Construct validity of epigenetic clocks 01:12:06 - Thoughts on most exciting research in aging field 01:13:44 - Dr. Morgan Levine's lifestyle habits 01:15:00 - Intermittent fasting effects on epigenetic age 23 Cody Johnson Cody Johnson 2 months ago Listening to these podcasts always makes me want to go back to college for biomedical engineering. 15 FoundMyFitness RWH RWH 2 months ago I appreciate Morgan's no nonsense approach. Everybody wants to hear there is a quick fix but she serves up the truth as she sees it. 13 FoundMyFitness Fat Boy Dim. Fat Boy Dim. 2 months ago Another brilliant upload. Although I amazed that most people don't realise there is difference between chronological age and biological age. 9 FoundMyFitness Joe Schmoe Joe Schmoe 2 months ago So thankful Rhonda! Life-changing information - for free! Such a public good. Science educators have no idea how much they impact the population. Truth is the greatest medicine. 5 FoundMyFitness Jon Sabes Jon Sabes 1 month ago Incredible work here by two of my favorites! #keepgoing!! thank you for the fine work in health and longevity you do! 1 FoundMyFitness Stealth Machines Stealth Machines 2 months ago I need like 10 times on repeat with these intellectuals...always educational!!! N fun!! 11 FoundMyFitness Orange Banana Orange Banana 2 months ago If there is ANYONE talking about longevity and aging, this is the woman to listen to; leading by example. Brilliant podcast! 2 FoundMyFitness Aldraz Aldraz 2 months ago This was really great and informative talk! 2 FoundMyFitness T D T D 2 months ago Thanks, as always, Dr Patrick... a gift. 14 FoundMyFitness Taylor Libby Taylor Libby 2 months ago I always have to lisren to these discussions from Dr Patrick at least twice to make sure my dumb brain gets a glimpse of the knowledge.😂🤣 49 Tim Slim Tim Slim 2 months ago Grateful for this knowledge and these strong and skilled women! 3 FoundMyFitness Sweet Fruit Sweet Fruit 2 weeks ago Aging is a disease. Thank you for this great interview. Stuart Berkowitz Stuart Berkowitz 2 months ago Would cell free dna tests like Grail allow us to capture fragments of dna from various tissues with high specificity (~90%), and at the same time allow epigentic aging by tissue type if enough fragments from each tissue are captured? 1 Douglas Dunlap Douglas Dunlap 1 month ago Thank you so much for all of this absolutely necessary health information ℹ️ Bruce Hutchinson Bruce Hutchinson 2 months ago Discovering and listening to Dr Patrick on Joe Rogan's podcast wasted beginning of me learning about nutrition getting off the standard American diet. And this going down all the rabbit holes I have found hope Physicians physician researchers and researchers about diet nutrition 1 Krissi Berry Krissi Berry 2 months ago HCG treatments are currently used to reverse inflammation. How does this affect epigenetics in cells? 3 Leonard M Leonard M 2 months ago Great information as always. 👍 Sean Byrne Sean Byrne 2 months ago Much looking forward to this discussion! 1 Daniel Train Daniel Train 1 month ago Talking about the lower levels of organization, I've always thought it's all related to changes in polarity. NML NML 2 months ago Thank you so much! So interesting! FoundMyFitness Melkiyad Melkiyad 2 months ago Amazing info :3 thank you for this 2 Angelic Annihilator Angelic Annihilator 2 months ago (edited) She is the perfect spokesperson for longevity research, she looks amazing and she's super smart :) 4 UHFStation1 UHFStation1 2 months ago I hope we find something that reverses aging without drastically changing lifestyles aside from not smoking and bad habits like that. I don't think fasting all the time is for most people. 1 Rayana Keita Rayana Keita 2 months ago Smart ppl beautiful inspiring women amazing podcast informative talk just love this channel 1 FoundMyFitness Martin Tippins Martin Tippins 2 months ago She said "there is no one cause of aging" but different species live very different life spans. Dogs and cats live only 20 years or so and parrots live to 90. So in my view there must be a genetic clock and we should be able to switch it off. I'll definitely subscribe if you can switch my clock off. Melkiyad Melkiyad 2 months ago What a great format update! 1 FoundMyFitness Obi z Obi z 2 months ago (edited) I use Morgan Levine's PhenoAge to track the impact of my diet. Interestgly, I did slightly better on a vegan + sardines + yogurt + cheese diet than I did on a vegan + sardines diet. 9 FoundMyFitness Arthas Menethil Arthas Menethil 1 month ago A first set of 71 CpG islands can fit the chronical age.. another completely different set can similarly fit... that basically argue against any shred of causality of the epi aging clock. Daniel Train Daniel Train 1 month ago It seems reasonable that the methylation is an indicator and therefore a marker than a cause. It should be pretty easy to prove. 1 The Al Stewart Archives The Al Stewart Archives 2 months ago (edited) So what are the actionable steps regarding optimising one's Omega 3 index? I eat Salmon twice a week, flaxseeds daily, but take no Omega 3 supplements - should I be getting blood work and supplementing based on the results in the same way I do with Vit D? - David 1 Dmitry Goroshkevich Dmitry Goroshkevich 2 months ago Hello. Do you suppose the lungs of a smoker be aging faster than other organs? Would a brain of a shift worker be aging faster? 2 Rick Rude Rick Rude 1 month ago Morgan Levine is a scientist with supermodel looks. 4 beepbeepnj beepbeepnj 2 months ago George Burns on his 100th birthday speech with typical martini and cigar in hand told the audience, "If I knew I was going to live this long, I would have taken better care of myself." 5 James Weatherspoon James Weatherspoon 1 month ago I've not gotten over the GMO clock, so independence vision is easier-- for me. Jesse Bradley Jesse Bradley 2 months ago I would love to understand why and what it means when illegal research made my epigenetic age 10 to the minus -43 youtuber42 youtuber42 2 months ago Any studies on GrimAge comparing long term diet effects? e.g. on long term low-carbers? J B J B 4 weeks ago Interesting book. But I must take issue with p195 where you say that lactic acid causes pain etc. Not true, we have known that's not the case for two decades (commencing with Nielsen et al 2001), though sports commentators keep on about lactic acid. It is used as an energy source for skeletal and cardiac muscle after its conversion to lactate. In fact, lactate can also be converted to glucose by the liver. Lactic acid is a relatively strong acid, and thus quickly separates into a hydrogen ion and lactate within the muscle fibres. Elevated levels of hydrogen ions cause the muscle to become more acidic. This in turn can stimulate pain receptors within muscles, causing discomfort and the exercise “burn”. 1 Barre86 Barre86 2 months ago This woman is going to be a super super super centinarian Larry Kraft Larry Kraft 2 months ago @FoundMyFitness, Thought you might enjoy knowing that I first heard of Joe Rogan as a result of taking in as much as I could find of your content here and on FoundMyFitness. Keep up the good work! 1 FoundMyFitness Jojo Jojo 2 months ago Mitochondria is the powerhouse of the cell. 2 Kj Jacobs Kj Jacobs 2 months ago With all due respect Dr Rhonda please try to shed light on the livers ability to heal cells by sending out photochemical compounds attached to amino acids and antioxidants to seek and heal the cell instead of only researching the cell. We fully get it oxidative stress is bad and antioxidants are good but the liver needs some light shed on it’s more than 2000 chemical compounds Yes 2000 not 500 3 ChessMasterNate ChessMasterNate 2 months ago I watch everything double speed, even this, and I understood everything...I think...except...where the floor ends and the wall begins. 2 Yuval Kapellner Yuval Kapellner 2 months ago (edited) You mentioned women epigenetic age being younger than man with same chronological age assuming similar lifestyle is adopted with women and as long as they get their period this stays consistent. Later you talked about the current hot topic which is young and old plasma exchange or even dillution which shows rejuvenation effect. Well, thete is a relationship here- women age is affected by their period since they lose blood which helps with rejuvenation procedures forced by the body. Now, most likely this could be observed just by drawing blood from men once a month for some time to validate the same. That is why prp treatment which is often used as hair growth catalyst or wound healing could also have this side effect on aging in a positive manner. Especially when done repetitively every x time. Some data suggests that there is a negative over accumulation of iron in aging blood and removing some of it enables rejuvenation to take effect 1 Roy Zlatan Estevez Roy Zlatan Estevez 1 month ago Aging is a metaphysical reality. No amount of human biomedicine can stop aging. aa bbb aa bbb 2 months ago (edited) Great podcast but the point ultimately becomes what does all this effort actually accomplish? Through not overeating and exercise alone you are getting the lions share of the benefits. Everything else seems like noise, including intermittent fasting, which is not even reproducible beyond mice data so far. The obsession is just a waste of time 3 William Dias William Dias 2 months ago Two beautiful and very intelligent woman talking about one of my favorite subjects , this one is going to be great !! 5 Krissi Berry Krissi Berry 2 months ago Any studies on epigenetic age reversal? 4 Arnold Wong Arnold Wong 9 days ago (edited) Idk if anyone can answer me this. So. If an epigenetic age test is comparing what your methylation pattern is against....sort of a Standard curve of methylation patterns. And the standard they use is based on the mass population, how do we know the population standard curve is necessary a good standard? So really the test is saying how well do you fair against the rest of society? Is that correct? StarKiller StarKiller 2 months ago Using a sunua and being in a fasted state before a Biological age test sounds like a good trick to cheat the results :) 2 Jesse Bradley Jesse Bradley 2 months ago Steve Hirvath has repeatedly refused to answer the question. 1 silverhranch silverhranch 2 months ago Hey Dr.Patrick, what do you put on your skin that makes it shine so much? Annuar Zirene Annuar Zirene 2 months ago 🙏🙌 Jason Guay Jason Guay 2 months ago Why are you not on Spotify as well? I will talk to them about offering you a deal! This is life-changing information. eric sevyn eric sevyn 2 months ago Great conversation. It would be even better if longevity researches like this would stop saying plant based diets are better for longevity. This is an archaic notion regarding mtor stimulation. Dig a little deeper please. 1 vindictii vindictii 2 months ago Damn, Dr. Levine looks like she has already reversed her aging 4 Emily Stornetta Emily Stornetta 2 months ago Genetics are only 10-20%...then why is the most significant predictor of your lifespan how long your parents lived? 1 Justin P Justin P 2 months ago Just wondering - how old is Morgan Levine? 1 dlb dlb dlb dlb 2 months ago Unless you can can change the epigenic clock all you are doing is looking at the speedometer. Nuke Laloosh Nuke Laloosh 2 months ago and this one time, at age acceleration camp spine1955 spine1955 2 months ago Poor Audio for YouTube. Please use better mics. Thanks, 1 Emily Stornetta Emily Stornetta 2 months ago Plant based...ugh. Not great if you are trying to drive protein synthesis or mostly trying to be low carb. Works for her as a very slender woman, not for a man that is trying to be muscular. 1 Katana Katana 2 months ago Some folks age like milk. 1 Bob Bobson Bob Bobson 2 months ago Where can we get a GrimAge test?? Augusto Semplice Augusto Semplice 2 months ago May I pay a compliment? Very smart and attractive Ladies indeed. :) Half Baked Alpaca Half Baked Alpaca 2 months ago mRNA vaccines and epigenetic aging? 1 Bryan Interlaken Bryan Interlaken 2 months ago Yeah, good luck with your plant based diets. lol Earwaxfire909 Earwaxfire909 2 months ago What do longer lifespan animals have that differs from shorter lifespan animals? 鄭楚珍 鄭楚珍 2 weeks ago ・被我发現/我发現 ・佢有幾間公司 ・其中一間公司，公司名稱NAME : FOUNDMYFITNESS FOUNDMYFITNESS類似健身中心， ・佢原來是老板闆佢原來是老板闆， ・我同你講： “俾心機做 ” “俾心機做” Rob Burgess Rob Burgess 2 months ago (edited) I'm listening on headphones and all the people talking in the background are a little distracting. 1 Menstrel Menstrel 2 months ago You only have to look at the English to realize that some people age in an accelerated fashion. 4 鄭楚珍 鄭楚珍 2 weeks ago POINT 3 POINT 3: DR DOCTOR RHONDA PATRICK ・学歷很高学歷很高 ・把我*** ***嚇親把我嚇親 ・QUESTION:边一方面那一方面 * * 嚇親我嚇親我？回答I GIVE ANSWER I GIVE ANSWER 我 回覆:/ANSWER ANSWER:高学歷高学歷 AND AND 和和 RHONDA PATRICK 非常聰明非常聰明 Brad Studio Brad Studio 2 months ago Eat a carnivore diet, don't drink or smoke, exercise often, do regular sauna and ice baths sessions, get proper sleep, and learn to manage stress properly. Solved. Annuar Zirene Annuar Zirene 2 months ago Save me reach out to me. I understand Betsy Westbrook Betsy Westbrook 2 months ago My mom got double pneumonia at 16 they read her the last rites. TB at 17 relapse at 36 cancer at 54 cancer again at 78. She is now 93 and going strong so I am not sure where disease is predictive of other serious illness shortening lifespan? 6 Your Name Here Your Name Here 1 month ago Secretly hoping they’d kiss. 1 Len Shuba Len Shuba 1 month ago These smart women are hot.. NOTREALLY HANKAARON NOTREALLY HANKAARON 2 months ago yes Bruce Hutchinson Bruce Hutchinson 2 months ago (edited) Discovering and listening to Dr Patrick on Joe Rogan's podcast was the beginning of me learning about nutrition getting off the SAD= standard American diet. And thus going down all the rabbit holes I have found -- many Physicians, physician researchers and researchers about diet nutrition 3 FoundMyFitness Nightwalker Nightwalker 2 months ago Lesgoooooo 鄭楚珍 鄭楚珍 2 weeks ago 評價非常高 把我*** ***嚇親。 把我*** ***嚇親。 thejackocat thejackocat 2 months ago Good content, of what I could hear. Stop mumbling please 2 John Tibaldi John Tibaldi 2 months ago The way she talks reminds me of Mark Zuckerberg🤔 1 鄭楚珍 鄭楚珍 2 weeks ago WELL ＆WISE WELL &WISE VIDEO :我間中ADVERB adverb: SOME TIME SOME TIME有看WELL& WISE VIDEO, 我是講事實/我不是捧 VIDEO捧到.很高，目的為了 捧/表面 稱讚人/我是真的講事實講REALITY。COMMENT:我对 WELL& WISE的评價COMMENT非常高。COMMENT：相當高。 ・I VERY VERY VERY BUSY I VERY VERY VERY BUSY 我根本無時間 我根本無時間 ・俾心機俾心機 WORK HARD WORK HARD ·我想 告诉 WISE &WELL , 我是香港的永久居民 不是美國人 發現POINT1:距離DISTANCE DISTANCE:香港HK 和美國之間的距離DISTANCE IN FACT IN FACT 事實上很遠 所以所以 我立場中肯。例如有 2幫 ：A幫 及 B幫，我立場不会偏幫 A幫， 我立場不会偏幫。 我冇 看完美國 公司 受間公司过往 普通人 的人講公司，我 聽到後，*** ***先入為主，我不会先入為主，我不会 其他人 影響我它公司的印象。 POINT 2: 評價非常高 Jacob Thomason Jacob Thomason 2 months ago Great topic here but I gave up. I find the interviewer to talk WAY too much. The concentration should be on asking questions such that the interviewee is speaking, not rambling around and repeating the same question 10x.