Autophagy

UNITED STATES The Most Important Benefit of Autophagy: Will Surprise You 736,241 viewsMar 4, 2020 Dr. Eric Berg DC 8.01M subscribers You really need to know about this important benefit of autophagy. Check this out. Autophagy Trigger: https://www.youtube.com/watch?v=SDpxU... Autophagy and Intermittent Fasting: https://www.youtube.com/watch?v=10jNZ... Dr. Berg Interviews Professor Thomas Seyfried on Cancer: https://www.youtube.com/watch?v=Yyt3D... DATA: https://cancerres.aacrjournals.org/co... https://www.researchgate.net/publicat... Timestamps 0:07 What is autophagy? 0:40 Autophagy benefits 1:37 The most important benefit of autophagy 3:48 Cancer cells love glucose 4:08 Why is there damage to the mitochondria? 5:03 Can autophagy clean up the damage? Today we’re going to talk about the most important benefit of autophagy. What is autophagy? Autophagy is a condition where your body is recycling old and damaged proteins in the body. I’m not talking just about hair and muscle. I’m talking about those little enzyme protein machines that do the work of the body. They’re at the cellular level, and they make body tissue. Benefits of autophagy: • It decreases the risk of disease • It will help recycle protein as a survival mechanism • It can help reduce pathogens in the body • It protects neurons and heart cells • It gets rid of advanced glycated end products and amyloid plaquing **The most important benefit of autophagy is anti-cancer. The difference between a normal cell and a cancer cell has to do with this one thing. A normal cell has something called mitochondrial respiration. A cancer cell has damage to this respiratory mechanism. When you damage this system, the cell starts to activate an ancient pathway that’s capable of fermenting glucose without the use of oxygen. Cancer cells are hungry for glucose. Why would anyone want to consume a lot of sugar or glucose if they have cancer? But why is there damage to the respiratory mechanism in the mitochondria? My theory is that it has something to do with the DNA that gets damaged. I believe it gets damaged because it's simply not protected. Autophagy may have the ability to clean up this damage in the mitochondria. Talk to a Product Advisor to find the best product for you! Call 1-540-299-1556 with your questions about Dr. Berg's products. Product Advisors are available Monday through Friday 8am-6pm and Saturday 9am-5pm EST. * At this time, we no longer offer Keto Consulting and our Product Advisors will only be advising on which product is best for you and advise on how to take them. Dr. Eric Berg DC Bio: Dr. Berg, 56 years of age is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of The New Body Type Guide and other books published by KB Publishing. He has taught students nutrition as an adjunct professor at Howard University. He no longer practices, but focuses on health education through social media. DR. BERG'S SHOP: http://bit.ly/2PLC1VR Follow us on FACEBOOK: fb.me/DrEricBerg Send a Message to his team: m.me/DrEricBerg ABOUT DR. BERG: http://bit.ly/3cuePp0 Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients so he can focus on educating people as a full time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Thanks for watching! I hope this video helps you better understand autophagy and the most important benefit of autophagy. Chapters What is etapag 0:00 Benefits of tofu g 0:40 Anticancer 1:35 777 Comments rongmaw lin Add a comment... Jew God Jew God 2 years ago Dr. Berg is like a cheerleader for fasting. Whenever you feel like quitting just watch a few of his videos you will never wanna eat again lol. 1.3K Dr. Eric Berg DC Schquirl 8811 Schquirl 8811 2 years ago I love how Dr Berg makes the scary and unknown actually understandable and manageable. THANK YOU FOR ALL YOUR HARD WORK! 447 Dr. Eric Berg DC I’m Done I’m Done 1 year ago Mr. Ohsumi (a biologist, if im not wrong) actually won a Nobel prize in 2016 for discovering the concept of autophagy. His research started way back in the 1990s. Autophagy is indeed a very important concept that everybody needs to know. Thanks Dr. Berg for the explanation..☺️ 117 julie bennett julie bennett 8 months ago (edited) Love all of his information. Very informative and simple to understand. I started intermittent fasting 3 years ago. I started out with a 4 day water fast. Started eating only 2 times a day. 12 hours apart. Now I only eat one time a day. And eat healthy. I have lost 30 lbs and feel good. 48 Debbie Debbie Debbie Debbie 2 years ago (edited) I did a 48 hour IF, next time I'm going to do a 60 hour and then try a 72 hour. I totally believe that everyone needs to do IF to Heal their body🌟 God Bless You and Your Family Dr. Berg FOREVER AMEN🙇‍♀️✝️🙏 185 Mariana Hernandez Mariana Hernandez 4 months ago I always had a feeling that our bodies can recover from anything but this system is against that and all about suppressing the symptoms. You reenforced my hopes. Recovery is more tangible than ever. It’s really possible 🥰 40 Destiny Destiny 1 year ago Perfect, perfect. I’ve been following the intermittent fasting lifestyle for 18 months now. I feel fantastic, my Spring hay fever has almost gone, I don’t get full blown colds, and I have lots more energy and also I walk 1hr a day. Thanks Dr Berg for all your informative information. 74 AstroBoyRicardo AstroBoyRicardo 5 months ago I lost 87 pounds with Intermittent Fasting and autophagy. Trust me, this process works. I'm now normal BMI and hardly get fatigue or severely sick! 36 Rebecca Jo Steelman Rebecca Jo Steelman 2 years ago (edited) Thank you always for everything you're doing to improve your fellow human's lives. Seriously, we cannot thank you enough! 🙏💗 I just went 22 hours fasting, not eating even the slightest snack. It is interesting that I came home in the middle of last night from work, feeling just a bit of hunger when I went to bed - yet when I got up today I didn't feel any hunger at all and went about my day for 5 hrs longer, and could have gone probably all day today without eating. I figure this is because my body is very well fat adapted, even though I've been allowing myself a bit more carbs per day, (of course mindful to not going over 50 grams), since I've gotten down to the weight that I want to be almost 10 mos ago. Is this correct? 14 Carol Miller Carol Miller 11 months ago Had to watch this twice but makes sense on a cellular level how cancer is triggered & fed. Modern life is attacking our cells on a regular basis but we're not defenseless thanks to Dr. Berg! 12 Tesh Patel Tesh Patel 1 year ago You know Dr Berg is super intelligence when he can explain something so complex in an easy to digest, visual form. It makes it fun and easy to watch for us mere mortals!! 45 Book Blogger Book Blogger 1 year ago I started 16.8 intermittent fasting and a fairly relaxed keto diet a week ago. I'm losing a pound a day. It's astonishing!! 45 John Gallo John Gallo 2 weeks ago Thank you Dr. Berg. Been watching you for years. Now I'm on my 3rd day of a 7 day water fast. Age 46. You have helped me out a lot over the years! Thank You! 👍 PortCanon PortCanon 2 years ago The Body is Absolutely Amazing!! Seriously, why was I not educated like this in high school?? And today, I’m a public high school teacher (who will always remain a student.) 378 Dr. Eric Berg DC Jacqueline Mackintosh Jacqueline Mackintosh 2 years ago (edited) The interview with Dr. Seyfried is a must watch! I've watched it a few times. Wish I'd known this before my late boyfriend passed of cancer back in 2016. I've shared it many times. 89 Dr. Eric Berg DC EYE OF GOD EYE OF GOD 2 years ago Thanks Doc, for another awesome video, they’re all usually great and helpful. 🤗 This one absolutely amazed me about how fantastic our bodies are 🧐 Along with your other videos it gave me more understanding of what happens when we eat refined Frankenfoods and the damage we cause them after years of eating rubbish. 😖 Onwards and upwards!!! 😘 5 c red c red 2 years ago (edited) Excellent presentation Dr Berg. The facts you brought forth can not only improve health, but save lives. A simple test that everyone should do - pick a day - my day starts Friday evening, I eat my last meal - whatever I want (keto/carnivore), then I don't eat again until Sunday morning. If I want a coffee or tea, go ahead, but avoid calories. Sunday morning have your first light meal, by noon you will feel like a king!... or Queen... try it just once... I used to do this each and every week, it became a very natural thing to do. I now do this a couple times a month as I'm building muscle and training for more strenuous calisthenics and crossfit . 4 datsuntoyy datsuntoyy 9 months ago When I was a kid, my mom was diagnosed with lung cancer that has spread. She then stopped eating entirely and died many months later at 67lbs. Autophagy may be great at preventing, not so great at curing. 27 Nick Rajotte Nick Rajotte 1 year ago Thank you so much Dr Berg, my dad has multiple myeloma with a mutation on chromosome 17 which carries an important tumor suppressor gene. Idk if I inherited this but I’ve found so many natural remedies that are cancer preventive from you and my own research. This is so reassuring and makes me hopefully for cancer treatment,prevention, and a cure. You are incredible, thanks again for sharing this❤️ 5 Angie Clark Angie Clark 5 months ago Thank you so much Dr.Berg..Watching your videos I’ve been doing I.F with low carb intake..So far I lost 12 pounds and I feel great already..Bless you ☺️You make it so easy to understand..My Dad actually recommended me to watch your videos . Anna May Anna May 8 months ago I am a big fan Dr. Berg. I did my first 48 hour fast this weekend...thanks for teaching me how to do fasting and Keto...it is working. I lost 30.4 pounds so far🙂🙂🙂 7 Wulz Hamilton Wulz Hamilton 1 year ago You've really changed my life, from watching a post about stomach acid I've went onto I.F. and LCHF diet, lost 5.5 stone and have no digestion issues at all, there all gone. A MASSIVE BIG THANK YOU 👍 15 SeanPerrin SeanPerrin 1 year ago Here's what surprised me. After YEARS of suffering from various symptoms and digestive problems, I actually, legitimately feel amazing by going low carb, adding digestive enzymes and considerable high quality supplements, and intermittent fasting 16/8 5 days a week. Thanks Dr. Berg! 13 Mechanical Experience Mechanical Experience 2 years ago Intermittent fasting has stopped my heartburn. I've been on omeprozole for years. I've had to cut caffeine because of my energy levels rising. Let alone losing weight and just feeling better. 57 Flying Horse Ministries with Elizabeth Gore Flying Horse Ministries with Elizabeth Gore 2 years ago (edited) Dr. Berg, thank you for spreading such important knowledge! You are such a blessing to all of us. (And your wife is a blessing, too!) 4 Faisal Rafique Faisal Rafique 2 years ago I am feeling very good fasting 5 days a week. Must be autophagy. 3 days : 16/8 hrs (workdays) 1 day : Full 24 hrs(Saturday) 1 day :20-23 hr (Sunday) 21 Pamela González Pamela González 1 month ago Thank you Dr Berg for your videos !! Helped a lot during a hard time with my health Lois Hunter Lois Hunter 4 months ago Thank you Dr. Berg because I understand more how my body function and stay healthier than before.I benefited so much from all the videos of yours that I saw which touch my problem specially of losing weight and insulin resistance. Again, thank you. ForgiveAndLove09 ForgiveAndLove09 5 months ago I’m fighting an illness and fasting is the only relief. The body knows what to do to heal. Fasting is the healing mechanism as we are designed with brilliance. 4 A human dream A human dream A human dream A human dream 2 years ago Since I started with intermittent fasting and followed your tips , I am a different person now and much more healthy , you are the best doc , thank you so so sooooo much 🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🙏🙏🙏🙏🙏🙏🙏🙏🙏 71 Zach Shuffield Zach Shuffield 1 year ago Hey Dr Berg, When you say you need fuel and it produces oxygen.. would a cancer cel cause you not to sweat during exercise? I randomly became unable to sweat, and I would instead breakout in hives. Went to many doctors that didn’t know what was going on, and one diagnosed me with exercised induced hives. I found your channel and did two 3 day fasts. I am completely cured and enjoy an active lifestyle again. Don’t know exactly how this happened but I am assuming the autophagy got rid of the bad cells that were causing this. Love your channel, and I really think the information I learned from you saved my life. 3 Natalie Peterson Natalie Peterson 2 months ago This is key information to an actual problem and its future consequences, for those who understand that's a matter of life. Thank you again, Dr. Berg, you are saving lives in great measure! 🙏💖 Liza Crouch Liza Crouch 4 months ago I have become a big fan of the amazing benefits of fasting since I first saw your video. I'm into my third week, although I've not lost much weight yet my midriff looks smaller. I am amazed at how my skin looks. It radiated as if I've turned back twenty years in a short time as a result of fasting and ketogenic diet.ive even ditched the bad habit of snacking and list my sugar cravings. Fabulously informative videos with good practical ways of feeling and looking good! 3 overcomer 2 overcomer 2 2 years ago I'm on my 5th day of extended water fast. Not sure how long I will last but this is good information. 14 Bernill Octave Bernill Octave 2 years ago You give me so much hope Dr,,,especially in this pandemic .,,,,i appreciate you Dr.🙌 17 It is what it is It is what it is 2 years ago Love your videos. Wish more traditional practicing doctors would wake up and start thinking outside the box. 16 Dr. Eric Berg DC O. MEZIAN O. MEZIAN 7 months ago Golden question to ask yourself starting from today What would I be risking if I did some of the things that are outside of my comfort zone? 5 Tony Montana Tony Montana 1 month ago Thank you Dr Berg for referring to the benefits of fasting so often in your great videos. As someone who read the books of the 3 great religions, the Quran is one that taught the importance of fasting over 1000 years ago. 1 Nora Carpio Nora Carpio 4 months ago Thank you so much Dr.Berg of sharing for all the important details about to care our body...love it....stay safe and may God bless you ...more health and live longer...❤️ 1 Robert C Lynch Robert C Lynch 1 year ago Very interesting. Back in 2005, I heard Tony Robbins talking about how sugar causes acid and acid causes chronic illness - including cancer. The statement that hit home was - ''Cancer can only survive in an acid environment''. Our bodies struggle to keep us in a slightly alkaline state, but a bad diet and polluted environment makes this very difficult. All of this acid/alkaline stuff ties in perfectly with the Keto lifestyle and the absolute game-changer is intermittent fasting. 2 Shreekanth Sharma Shreekanth Sharma 2 months ago I am duo-located in London and Bangalore, a big fan of fasting, driven from both diet & religious orientation. Dr Berg's reinforcements in terms of recommendations and advice are incredibly motivating. 5 saturnslipper saturnslipper 7 months ago (edited) This is such a powerful motivation not to eat sweet things or sugar! Lost a friend this year to liver cancer. She was trim and looked fit but loved eating sweet things: sweet tea, asian cuisine, breakfast sandwiches, hamburgers, pastries, take out restaurant meals and chocolate. All of these foods have added sugar and she kept feeding her cancer, fertilizing it until she was consumed by it. 😫😔 3 L M L M 1 year ago (edited) My grandparents from Romania always fasted before Christmas and Easter "to clean the body from inside "! 120 Dyah Viona Dyah Viona 2 years ago Wow! This video is gem. Super informative and useful yet so short and easy to understand even for me that isn't speak English daily. Thanks dr. Berg! 4 S Jordan S Jordan 2 months ago Thank you so much for speaking on the topic of autophagy. I have Endometrial Cancer, having three treatments of vaginal vault brachytherapy, which I am less than happy about. I choose to eat a plant based high fiber low fat, low protein diet, using organic non GMO foods, no sugar, no processed foods. The quandry is that some doctors say that autophagy is a two- edged sword and can increase cancer growth, as well as decrease its growth, however I can find no information which discusses to what extent, or if cancer growth happens more or less during autophagy. Please would you elaborate on this topic? I intend continuing my 72 hr water fasts, because already my body feels more alive than it has in years, so I must be doing some good! 1 Tajmeel تجميل Tarfeeh ترفيه Tajmeel تجميل Tarfeeh ترفيه 2 years ago Another deep enlightenment of silence, My cells and good Bacteria Say thanks to you Dr. Berg 33 Dr. Eric Berg DC Joyce Kibler Joyce Kibler 2 years ago Wondering about your thoughts on fasting for a person with high iron? I’ve heard conflicting information. I have high iron and would like to know what you think. Thank you for all of your research and teaching. It is so helpful. 1 Dr. Eric Berg DC Bid Now Bid Now 2 years ago I think that it is prudent to say that fasting and autophagy MAY help in regards to (some types of) cancer. This is very new science, so it is premature to make really bold claims. Keto, exogenous ketones, and fasting/autophagy are recognized as perhaps useful ADJUNCTS, or complimentary diets, but not curative. This is much more complex than a 6 minute video, so viewer caution is advised. 5 mimi27513 mimi27513 2 years ago (edited) 3:55, how furious it makes me that an oncologist that should know this (“cancer cells are extremely hungry for glucose”) would advice a parent of a child receiving chemo therapy to “eat and drink whatever they like”. That didn’t sit well with this parent, but at that time uneducated about cancer, I trusted the doctor. Lots of research following diagnose makes you wonder how they can continue to give this type of advice. I regret that at that time I was uninformed and after chemo treatments went and got sugary, syrupy ice drinks from Sonic on that ok from the doc. So wrong. 127 Micah Richey Micah Richey 2 years ago You are amazing Dr Berg! Thank you so much for all of this information! 2 Desiree Hennequin Desiree Hennequin 2 months ago I have really been enjoying watching your videos with such great explanations. I suffer from anaemia. I can never keep up with my B12, D and iron. I am on D compound, B12 injection and iron transfusion regularly. My health hasn't been great for the last year and I barely have an appetite and struggle with sleeping. I have also lost a lot of weight and hair. Nutritionist from the hospital are always telling me what I cannot eat. I was wondering if you can give me any suggestions or links to videos that you might already have. I like to think that I am not the only one going through this. Thank you 🙏 Diana Lee Diana Lee 5 months ago Dr. Thank you so much for all the great knowledge you pass onto us,! 2 vamshi krishna vamshi krishna 2 years ago I am watching this as I am on 24 hours fasting .. currently my body undergoing autophagy phase (15 hours past) 7 Donna Bane Donna Bane 2 years ago So much information broken down in plain and simple terms. Thanks so much. 2 Rudy Baldovino Rudy Baldovino 2 years ago Thank you so much Dr. Eric Berg well done sir! You help me a lot I feel like 30 years younger! 1 DirtIsBetter ThanDiamonds DirtIsBetter ThanDiamonds 2 years ago This is EXACTLY the reason we leave crop fields lay fallow for a time..our bodies are no different! 136 Dr. Eric Berg DC Junming Zhu Junming Zhu 9 months ago Thank you Dr. Berg to educate me in such an easy to understand way! A lot of times I was buried in the new word and process from other presenters. Lore for One Lore for One 4 months ago I've heard of this cancer /sugar connection. Great explanation 👍 Kevin McNamara Kevin McNamara 2 years ago Dr.Berg, As always have been so informed by “Autophagy video”. My question is,in that some cancer cells like prostate,unique characteristics exist.Does this lecture apply what might be considered the “prostate model” of the pathology? 8 Dr. Eric Berg DC Tiera Baz Tiera Baz 1 year ago Thanks a lot Dr Berg for a great video and for the advice and information C. Galindo C. Galindo 1 month ago So cool. I love this. It really speaks volumes to me. I should have discovered this channel long ago but glad I found it now. Thank you for your knowledge and expertise Doc Keytoketo Keytoketo 2 years ago (edited) Absolutely incredible work.. autophagy is absolutely amazing, thank you for these videos. 4 Bill Perreault Bill Perreault 2 years ago great video by Dr. Berg. he is right on and this is factual. a must read for everyone. Jacqueline Mackintosh Jacqueline Mackintosh 2 years ago Dr. Berg ~ I didn't realize how much of a hit I took when I lost my sister last year. When I began eating and getting back into keto & IF that's whey the lyme meningitis hit so hard, it has affected my memory, body temp, and eye sight. Every time I try to get back into keto I get extremely ill, this never happened before. I ordered your electrolytes, I've been using your wheatgrass juice powder & cruciferous supplements. I'd be grateful for any advice. Thank you. Bobby Ocampo Bobby Ocampo 6 months ago (edited) Hope they will have research on reversing different deseases. 1. Atherosclerosis 2. Kidney Desease 3. Retinopathy 4. Neuropathy 5. Fatty Liver desease 6. Pancreatitis, etc 2 Lucas Filewalker Lucas Filewalker 9 months ago Q: Does being in the state of autophagy dissolve spike proteins and rid the body of the poisonous covid injections overall? Thank you. Andy Ax Andy Ax 9 months ago (edited) Learning so much and approaching my diabetes from a totally different angle. KETO diet and 20/4 fasting. But have a question. Will autophagy remove oxidised LDL's? 2 Erika Erika 7 months ago I love fasting and always feel great after. It amazes me how many people cannot give up food to benefit their bodies. 🥰'👍👍 Jelly17 Jelly17 3 weeks ago I did 16:8 off and on for 2 weeks and fell back down and started eating bad but this video made my eyes open once again. I will start to fast again. Does anyone know if it’s OK to fast everyday? I’m a 31 YO working mom, so I’m not sure if it’s healthy to put my body in stress mode everyday? 1 The Disciple Whom Diogenes Loved The Disciple Whom Diogenes Loved 2 years ago Wow, Dr. Berg! You did a REALLY good job in this video! 7 Dr. Eric Berg DC Brad Fiscel Brad Fiscel 2 years ago Thank you Dr Berg for your knowledge to getting healthy naturally God Bless. 1 PlayStayFit PlayStayFit 2 years ago Why intermittent fasting and not fasting in general? Could you please make a video on Ramadan and how to get most use of the fasting hours without drinking? Thank you for your extremely informative videos and hardwork!!! Balkis Mohamad Balkis Mohamad 2 years ago Hello Dr. Berg. Thanks for the helpful videos. Can you help with OCD? Matthew Wilson Matthew Wilson 2 years ago Thanks for all you do Dr Berg. Could you please do a video on ulcerative colitis specifically and any tips on overcoming this? Autophagy works better than anything but any other info would be awesome. 2 Darcy Turnbo Darcy Turnbo 1 year ago Finally made it to OMAD. So happy with ketosis. I’ll never go back! 92 Testing Instruments Testing Instruments 10 months ago (edited) Great advice and presentation. I fast 36 hours twice in a month. Is that enough to produce autophagy. Doctor is a great guy to help people in the universe. Thanks 1 Linda Bell Linda Bell 4 months ago I have never been so impressed with any doctor. Thank you. Question: Microbes are opportunistic, given. How do I convince microbes to feed on protein debris rather than villi? MrPrios1 MrPrios1 10 months ago This is awesome, I have been talking to my family and friends about this since 2011. Dave Porter Dave Porter 2 years ago Another gem of great information. THANK YOU SIR! 1 Dr. Eric Berg DC JUAN MARCUZ TIMAY JUAN MARCUZ TIMAY 9 months ago "Cancer cells are extremely hungry for glucose. They hug glucose than normal cells." (Dr. Eric Berg) 3 G. G. 5 months ago Such a informative video, :) I had cancer myself, I'm also big fan of fasten, thank you for your incredible work, greetings from Germany Tajmeel تجميل Tarfeeh ترفيه Tajmeel تجميل Tarfeeh ترفيه 2 years ago Another deep enlightenment of silence, My cells and good Bacteria Say thanks to you Dr. Berg 2 Dr. Eric Berg DC DrDina Perez-Neira DrDina Perez-Neira 1 year ago No words to thank you enough. Im sure that you have saved many lives. 2 Brian Joyce Brian Joyce 2 months ago Good info to incorporate with the health/weight stabilizing strategies/lifestyle. Thx man C. M. C. M. 4 months ago Can you do a video explaining how to end a fast, as in what to eat for those first few meals to achieve the best results as the body resets and starts fresh after a fast? Would it be best to start with fermented foods, or veggies, etc., etc., ? Also how long of a fast? I do IF most, but not every day currently, but haven't done a 24 or 48 hour fast in a while. 2 Maxi Bake Maxi Bake 2 years ago Brilliant advice. Thank you muchly for sharing this very important information with us all, & take care of yourself too. ❤🙂🐶 Sam ferguson Sam ferguson 2 years ago I wish their were doctors like you here in Australia Dr Berg.....Doctors here are so so closed minded...Just love giving people pills...I am sure they have shares in the pharmaceutical companies....And to make it worse the majority of the community are so closed about it as well because their doctors are.....SAD......Hopefully people will get educated through videos like yours like we have....Thank you for the all the study and research you share....Same wife 1 Victoria O'Shea Victoria O'Shea 4 months ago He's a great teacher and truth teller! 최재호 최재호 2 years ago fasting is really good on healthy body and mind. your lecture has been a beneficial to ordinary peoples. if just always want to say to thank you a lot. Rene Rene 3 months ago I think the value of autophagy and fasting might really kick in once you have removed all vitamin etc deficiency problems 1 Orwell rolls over... Orwell rolls over... 1 year ago I fasted for 2 days straight followed by a full month of keto, i was low weight and have A+ blood type, i lost my little bit of fat but I also lost muscle mass which is awful for a tall skinny guy like me in my 40s. It took me 3 months to rebuild the muscle I lost. Now in on a high carb diet with decent levels of protein and far , I avoid omega 6, avoid raw sugar and now I'm gaining muscle slowly and I continue to loose fat to the point I'm starting to get ripped. I am afraid to ever go to keto again. How do I use fasting to gain the benefits of autopogy without losing muscle noting that during my failed keto I was having large meals full of animal fat, butte, cheese , olive oil, avocados and green leafy vegetables for vitamins. Pam Hairston Pam Hairston 3 months ago Thank you so very much for sharing your knowledge ......I will now do my part to pass it on 😊 korich korich 2 years ago Thank you Dr Berg. I used to believe that glucose/sugar is not a poison, but it looks more and more like it is. Would it be an over statement to say that sugar, in any form, is a poison? (not that artificial sweeteners are necessarily better than sugar) 1 Qalandar Khan Qalandar Khan 4 months ago Fantastic. What a great information in a few minutes.Thank you a million times Pottenger's Human Pottenger's Human 2 years ago Ribosomes are what mainly gets recycled when fasting. This is what the virus needs to reproduce itself, so fasting is great for avoiding or curing infections. 4 Robyn Fitzsimmons Robyn Fitzsimmons 2 years ago So interesting Dr Berg. So much to learn. THANKYOU. 1 Dr. Eric Berg DC Aquarius ZO Aquarius ZO 1 year ago Great videos. THANK YOU FOR ALL YOUR HARD WORK! Is autophagy stronger during sleep? During a 72 hrs fast we are sleeping 24 hrs, is this a loss of autophagy benefits? 5 Eli Cohen Eli Cohen 5 months ago Can you kindly show any reference to intermittent fasting and autophagy in humans? Because as far as all the research papers I have been reading you must water fast at least for 72 hours to enter autophagy state. Intermittent fasting produces "some" liver cells to enter into autophagy but not the entire body where as a water fast makes every single cell in the body enters autophagy after 72 hours. Animated biology With arpan 112K subscribers How long do you have to fast before autophagy? How can you trigger autophagy without fasting? How do you encourage autophagy? What triggers autophagy? Does autophagy happen with intermittent fasting? How long should you stay in autophagy? What can I eat during autophagy fasting? How do I know if I'm in autophagy? Also follow me on other social media - Facebook: https://www.facebook.com/arpan.parich ... Instagram: https://www.instagram.com/arpanparichha/ Linked in: https://in.linkedin.com/in/arpan-pari ... Twitter : https://twitter.com/arpan_parichha?la ... Instagram page : https://www.instagram.com/animatedbio... Link to my other channel - Lets crack bio exams https://www.youtube.com/channel/UC4Ip... For Physics part of bio exams - Physics for IIT JAM biotechnology https://www.youtube.com/channel/UCJvS... #animated_biology #animated_biology_with_arpan #biology #bio_facts #CSIR_NET #IIT_JAM #IIT_JAM_BT #biotechnology #bioscience #biological_sciences #microbiology #genetics #zoology #molecular_biology #cell_biology #botany #immunology #ecology Chapters Does intermittent fasting induce autophagy? 0:00 Autophagy Autophagy is a process in which a cell eats its own contents 1:23 Prolonged fasting induces autophagy 2:26 Which Intermittent fasting paradigm is best for inducing autophagy 4:44 Alternate day fasting 5:06 18:6 intermittent fasting 5:44 Buy Animated biology With arpan merchandise $19.99 Spring $14.99 Spring $19.99 Spring $19.99 Spring $14.99 Spring $25.99 Spring 22 Comments rongmaw lin Add a comment... Kamanashis Roy Kamanashis Roy 3 months ago We should add the role of acetyltransferase and P300 protein that inhibits the Autophagy. So low energy = lack of Acetyl-coA = inactive Acetyltransferase = inactive P300 = Autophagy. Also, once a day meal could cause autophagy when walking/aerobic exercise is incorporated. Or if we add Spermidine or autophagy inducer. 4 Animated biology With arpan Carlos 22 Carlos 22 2 months ago Can the Macrophages that cause autophagy create inflammation ? I had read it can. What are your thoughts ? I’m battling Rheumatoid Arthritis and I’m not sure about fasting. 1 Animated biology With arpan RedDevil_Joe RedDevil_Joe 3 months ago We don’t know if autophagy slows down after 48 hours of fasting though do we? There’s nothing to suggest it does, I’ve also seen studies that say if you aren’t already in ketosis you have to fast for 72 hours just to induce autophagy? 2 Animated biology With arpan Bobby Bobby 2 months ago how often should you induce autophagy? 3 Animated biology With arpan lazzy2012 lazzy2012 1 month ago Would this help for a fungal infection Such as jock itch? 1 Animated biology With arpan Esteri G. Esteri G. 1 month ago How many calories and what kinds of foods for the alternate day fasting. 1 Animated biology With arpan Esteri G. Esteri G. 1 month ago Are you saying there is absolutly no autophagy with shorter fasts used in daily intermittend fasting? Is there no benefit from the shorter fasts. If i do 36 hours once a week will that do significant repair? and then pair with other shorter fasts? 2 Animated biology With arpan Rabbit Girlz Rabbit Girlz 3 months ago Does intermittent fasting cause reverse t3 levels high. 1 Animated biology With arpan Hector el mexican Hector el mexican 4 weeks ago Some studies show 17 hrs 1 Animated biology With arpan STAR W STAR W 1 month ago So how many hours tell autophagy 1 Animated biology With arpan Dr. Berg, does autophagy shrink loose skin and can it unclog arteries? I notice I look way younger when I do IF, as well. Toni Martin Toni Martin 5 months ago Dr. Berg: when i do IF, which I try to do everyday , mostly 16-8 or 20.. some days I have so much energy and feel so good... and then sometimes it's so hard to go to sleep after a day of this.. What is this? I love it! Just hard to bring it down a notch. Thanks for all you do.. AngelH AngelH 5 months ago Why are we not told about this stuff like anywhere.?! I have never heard of this subject and I’ve worked in healthcare all my working life since the 1970s!! Thank you so much! Melanie Moore Melanie Moore 2 years ago I have been doing Keto for 2 years doing 2 meals a day with an 18 hour fast. I gained 15 pounds recently So I figured try the OMAD keto due to Autophagy and other benitifits but the hunger pains at night wake me I can't sleep without getting up and eating a fat mid night. I have no clue why this is going on. I still have ketones in my urine so no idea why hunger pains? 1 Mars Lewis Mars Lewis 9 months ago One thing I have noticed while in autophagy is that eye floaters appear to be dissolving and going away. 3 Martin Monsalvo Martin Monsalvo 2 years ago (edited) Hi doc: I would like to know if Flaxseed and Chia oils are healthy enough to be included in a Keto diet. Are they good for the liver? Thank you so much for all you do! FoundMyFitness 424K subscribers Dr. Guido Kroemer is a professor at the University of Paris Descartes and an expert in immunology, cancer biology, aging, and autophagy. He is one of the most highly cited authors in the field of cell biology and was the most highly cited cell biologist for the period between 2007 and 2013. Especially notable among his contributions: he was the first to discover that the permeabilization of mitochondrial membranes is a concrete step towards apoptotic cell death. This episode is decidedly focused on autophagy, an important cellular program that is inducible by dietary fasting and has broad implications for aging and cancer. Autophagy discussion includes: • 00:04:44 - How the 3 main signals that activate autophagy all involve nutrient sensing. • 00:16:30 - The role of different types of fasting and nutrient deprivation in autophagy. • 00:24:35 - How different types of exercise can induce autophagy. • 00:32:04 - How a specific type of autophagy called mitophagy keeps mitochondria healthy. • 00:33:07 - How autophagy has been shown to slow cellular aging. • 00:35:13 - How autophagy prevents neurodegenerative diseases by clearing away protein aggregates. • 00:44:04 - The role of autophagy in cancer as a possible double-edged sword. • 00:50:27 - How certain compounds known as caloric restriction mimetics (or fasting mimetics) including resveratrol, spermidine, hydroxycitrate can induce autophagy by tricking the cell through the modulation of one or more of the 3 main autophagy signaling pathways. Chapters: 00:00:00 - Introduction 00:00:25 - What is autophagy 00:06:13 - Acetyl-CoA 00:12:37 - Measuring autophagy 00:16:29 - Inducing autophagy 00:24:26 - Exercise 00:26:52 - Types of autophagy 00:35:11 - Neurodegenerative diseases 00:39:52 - Sickness response 00:41:42 - Cancer 00:50:22 - Fasting mimetics 00:59:17 - Kroemer's healthy habits ▶︎ Dr. Kroemer's Lab Website http://www.kroemerlab.com/ --- Links related to FoundMyFitness: ▶︎ Subscribe on YouTube: http://youtube.com/user/FoundMyFitnes... ▶︎ Join my weekly email newsletter: http://www.foundmyfitness.com/?sendme... ▶︎ FoundMyFitness Genetics: http://www.foundmyfitness.com/genetics ▶︎ Crowdfund more videos: http://www.foundmyfitness.com/crowdsp... ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/fo... ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness Chapters Introduction 0:00 What is autophagy 0:25 Acetyl-CoA 6:13 Measuring autophagy 12:37 Inducing autophagy 16:29 Exercise 24:26 413 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 4 years ago TIMELINE... • 00:03:22 - How genetically inhibiting autophagy actually increases cellular sensitivity to death and how this was counterintuitive because autophagy was thought, at one time, as a type of activity predominantly concerned with actually initiating cell death. • 00:04:44 - The external signals causing autophagy. • 00:05:29 - The role of growth factors in transporting nutrients from the outside world into the intracellular space. • 00:05:48 - Autophagy as a process that destroys bioenergetic macromolecular reserves including proteins, lipids, and nucleic acids to generate energy. • 00:06:28 - How declines in the ATP (energetic) status of the cell trigger autophagy by increasing the activity of a pathway known as AMP Kinase. • 00:06:36 - How reductions in the cytosolic pool of acetyl-CoA as a consequence of reductions in glycolysis, amino acid catabolism, or beta-oxidation, ultimately result in the de-acetylation of hundreds of cellular proteins involved in autophagy. Nutrient deprivation → ↑ Protein Deacetylation (↓ cytosolic Acetyl CoA) + ↓ mTOR + ↑ AMP Kinase → Autophagy • 00:09:37 - The role of the inhibition of mTOR and activation of AMP Kinase in cellular autophagy. mTOR is a pathway robustly activated by IGF-1 and associated with increases in cell growth, proliferation, motility and protein synthesis. AMP Kinase, on the other hand, is a pathway important in regulating cellular energy homeostasis by inhibiting synthesis of fatty acids and triglycerides and activating fatty acid uptake and beta-oxidation in the liver. • 00:09:37 - The indirect relationship between protein acetylation status (and cytosolic acetyl CoA availability) and the suppression of mTOR and activation of AMP Kinase in cellular autophagy. • 00:10:23 - The possibility of using selective nutrient restriction as an autophagy-inducer instead of more generalized nutrient deprivation or fasting. • 00:11:11 - Cytoplasmic protein deacetylation as a potential surrogate marker for fasting-induced autophagy (still undergoing validation) but possibly not other forms of autophagy, such as the kind pharmacologically induced by interaction with a protein involved in vesicle-trafficking processes called Beclin 1. • 00:12:53 - How a protein called LC3 associate with structures called autophagosomes to facilitate autophagy in response to deacetylation it undergoes. Note: this sirt1-mediated deacetylation of LC3 is induced as an important response to cell starvation. • 00:14:22 - The special flow cytometry needed in order to measure some of the proteins associated with the activation of autophagosomes in autophagy. • 00:15:04 - The desirability of being able to know and test whether or not your fasting is triggering robust autophagy or not. • 00:16:30 - The minimum amount of fasting necessary to activate autophagy. • 00:16:56 - Whether or not time-restricted eating or 16:8 intermittent fasting reliably induces autophagy in any of our tissues. • 00:17:57 - The important differences between prolonged fasting in humans and the rodent animal models used in studies. • 00:19:03 - The ~12-hour half-life of IGF-1 and whether or not that has any implications for the potential of autophagy in shorter duration fasts. • 00:20:12 - The effects of long-term caloric restriction on markers of cellular autophagy in humans. • 00:21:32 - The effect of an every-other-day eating pattern in rodents and how this pattern actually mimics the longevity producing effects of caloric restriction but with the advantage of stabilizing long-term at a more normal body weight. (Note: Dr. Kroemer is quick to point out that this type of intermittent fasting is more dramatic than it would be in humans because of differences in metabolism… the animals actually experience a 10% oscillation in body weight from this pattern!) • 00:24:35 - The effect of exercise (especially endurance exercise) on autophagy in muscle tissue. • 00:25:08 - The role of autophagy as a mediator of the anti-obesity and anti-diabetic effects of endurance exercise. • 00:26:58 - The differences between macroautophagy, microautophagy, and chaperone-mediated autophagy. • 00:28:03 - The difference between autophagy that is dictated by demand (nutrient stress) versus autophagy that occurs as the need arises to recycle damaged organelles. • 00:28:40 - How damaged organelles change the composition of their surfaces in order to decorate them with signals for the stimulation of their engulfment by the autophagosome. • 00:29:07 - The many, many names autophagy has when we are talking about it in the context of specific macromolecular structures and organelles (e.g. mitophagy for mitochondria, pexophagy for peroxisomes, reticulophagy for endoplasmic reticulum, ribophagy for ribosomes, and virophagy for viruses). • 00:29:35 - How autophagy from nutrient deprivation still prefers to first recycle organelles that have been slightly marked… in other words, that are already aged or slightly damaged. • 00:31:15 - How mitochondrial use ubiquitination, a process which occurs when these organelles begin to lose their membrane potential, in order to signal damage and to ensure preferential targeting by the autophagic machinery. ↓ mitochondrial transmembrane potential → ↑ ubiquitination → ↑ mitophagy • 00:32:42 - The coordinated manner in which mitophagy and mitochondrial biogenesis act together in a closed feedback loop in order to preserve mitochondrial quality while preserving the total pool of functioning mitochondria. • 00:33:34 - The changes that can occur in total mitochondrial pool as cells adapt to take on new metabolic profiles through a mitophagy-mediated process. This can occur as cells differentiate into new cell types that are specialized for glycolytic energy generation. • 00:35:13 - The role autophagy plays in the prevention of neurodegenerative diseases caused by protein aggregates. • 00:37:18 - How autosomal recessive mutations (where both parents must contribute a defective gene for PD to arise in the offspring) in a kinase protein called PINK1 disrupts its ability to recruit a protein called Parkin that mediates the targeting of mitochondria for mitophagy. ↓ PINK1’s kinase activity → ↓ parkin recruitment → ↓ mitophagy → ↑ accumulation of damaged mitochondria • 00:38:01 - Mitochondrial membrane permeabilization as a death signal due to the release of dangerous proteins contained in the mitochondria. • 00:39:05 - Dr. Valter Longo’s research demonstrating a cycle of prolonged fasting followed by a refeeding can recycle 28% of the white blood cells, and reduce the severity of an autoimmune disease (multiple sclerosis). • 00:39:52 - The evolutionarily-conserved sickness response (food avoidance) as a way of beneficially altering immune responses through through altered metabolism and autophagy. • 00:41:02 - The surprising increase in lethality that happens when mice are force fed (glucose in this case) while exhibiting sickness response from a bacterial challenge. • 00:42:27 - The effects of an anti-malarial known as chloroquine which has some cytotoxic effects in cancer cells, but is actually (surprisingly) an inhibitor of autophagy. • 00:43:12 - Studies of the lysosomal disrupter and anti-malarial chloroquine in combination with chemotherapy in the treatment of cancer. • 00:44:04 - The differential roles autophagy plays in the progression of cancer in pre-malignant cells, when it is suppressed, versus in malignant cells, when it is sometimes used as an adaptation helpful to the survival of malignant cells experiencing environmental stress. ↓ tumor suppressor gene activity → ↓ autophagy → survival of pre-malignant cells → ↑ autophagy as a malignant adaptation • 00:44:49 - How inhibition of autophagy by itself is sufficient to induce oncogenesis, particularly in leukemia. • 00:48:10 - How cells undergoing autophagy can release ATP into the extracellular space where it can function as a signal that recruits and activates immune cells against tumor antigens through the activities of purinergic receptors. ↑ autophagy → ↑ extracellular ATP → activation of purinergic receptor-mediated immunosurveillance • 00:48:49 - The importance of the triggering of this immunosurveilance system as part of the cell death associated with chemotherapy. • 00:50:27 - The class of compounds known as “caloric restriction mimetics” that affect autophagy by perturbing various pathways in such a way as to reductions in cytosolic acetyl CoA and protein deacetylation in a manner similar to nutrient deprivation. Examples include: hydroxycitrate (inhibits ATP citrate lyase), spermidine (inhibits Ep300, a protein acetyltransferase), and resveratrol (activates deacetylases). • 00:55:27 - How intestinal bacteria may produce as much as 1/3rd of the body’s spermidine and how this production rate can be manipulated by probiotic and dietary interventions. • 00:56:17 - How the ability of caloric restriction mimetics (CRMs) to induce a type of autophagy that provokes immunosurveillance potentially offers an opportunity for synergy when used in combination with chemotherapeutic agents in the treatment of cancer. • 00:56:56 - How the inhibition of autophagy in malignant cells or destruction of the extracellular ATP released by cells undergoing autophagy is able to abolish the favorable interaction between caloric restriction mimetic drugs and chemotherapy. • 00:58:02 - The tendency for dietary consumption of caloric restriction mimetics, particularly hydroxy citrate, to induce autophagy and reduce weight gain in mice fed an obesogenic diet. • 00:59:17 - Dr. Kroemer’s personal intermittent and prolonged fasting practices and his habit of consuming foods that may contain some natural quantities of caloric restriction mimicking compounds. • 01:01:40 - The autophagy-enhancing effect of coffee (with and without caffeine). 171 swordfishK2 swordfishK2 3 years ago I consider myself very fortunate to be living in an age when this type of information is so readily available to the common man. 134 tyanite1 tyanite1 3 years ago (edited) How intelligent is this guy! Wow, a knockout interview. Also, I can tell you took the time to edit the closed captioning, which isn't easy or quick. Wanted to express my appreciation for that, because having captions on helps me concentrate and retain information. Thank you for producing all these high quality, informative videos. 110 FoundMyFitness Dave Oatway Dave Oatway 4 years ago I really appreciate your interview technique - you let the guest talk, and then summarize and help expand the guest's points. Thank you! 84 Rahoul G Rahoul G 4 years ago Rare to find a raw , unfiltered podcast that focuses on the science , without dumbing it down to pander to the audience. I didn't understand a lot of the cellular mechanisms entirely , but the numerous papers being cited, motivate me enough to find out. Dr Guido seems like on of the most knowledgeable persons I've seen on your podcast, its impressive to hear the breadth of his knowledge. P.S Spermidine in cheese in synergy with resveratrol in wine , would be interesting to see if this is a reason behind the French longevity paradox. 30 Derek Robbins Derek Robbins 3 years ago Fantastic interview, even more remarkable when you think that English is the second language from Dr Kroemer! He speaks better English than most of us native speakers. I find that the people with the most knowledge and intelligence are very calm and don't let their emotions get involved with their answers. I didn't understand everything he was talking about but bit by bit, I am getting very interested in fasting and autophagy. When a man like Dr.Kroemer is on OMAD plus prolonged fasting, not to mention wine and cheese! That is good enough for me Thanks and keep them coming! 28 Ken Gaskins Ken Gaskins 1 month ago This was an excellent episode. What a brilliant mind, and a superb moderator/scientist asking all the right questions. Fascinating! 2 PtrPilot PtrPilot 3 years ago Top 10, or even 5 here Rhonda, this was an exceptional interview! There is beauty in science, you know how to waltz with intellects and match them step for step. There were so many "connect the dots" moments for me in this one, I'm sharing it far and wide, and coming back for the encore. Bravo, and many thanks to Guido for coming on, he clearly appreciated your considerate, intelligent interview style. So grateful for your work, thank you. 8 Cornholio The great Cornholio The great 4 years ago Really appreciate the time you take to create the helpful diagrams/definitions in the video. Ive only done 2 semester of biochem so far hehe 25 FoundMyFitness * Seasonednuts * Seasonednuts 4 years ago Great video! Have been following you since I came across your lecture on hypothermic conditioning and epigenetic mechanisms. You have a great way of expressing information so it's easily understood. I have put your science into practice and have seen tremendous results at 39. Eating 1 meal a day for 7 months I've lost 45lbs and gained a whopping 18lbs of lean muscle mass. After around 18hrs my t levels and igf-1 literally go through the roof so it feels. I hope you read this because I really want express my gratitude for your work and helping people. Great work Dr Patrick! 7 FoundMyFitness Jim V Jim V 4 years ago Nice job Dr. Patrick, your videos are getting better and better :) The extra multimedia inserts make these things so much easier to understand for the rest of us. 19 FoundMyFitness Aneil Mayank Aneil Mayank 4 years ago (edited) I would like to offer my sincere thanks for this incredible information. It was so interesting to listen to and extremely helpful. I am going to start implementing 3 days water fasts every month for the autophagy benefits now!! 5 kineticx kineticx 10 months ago Huge thanks for you and your team offering the non-academic interested audience the latest progress on research, and these amazing illustration is pulling us to keep up, This channel offers one of the most professional and responsible content in this field; big thanks and respect 1 Ronald Weiner Ronald Weiner 3 years ago This was an amazing presentation!! It really helped connect the dots on how these mechanisms can dictate the outcomes in health and disease. I would certainly be interested in your thoughts on his personal regimen of prolonged fasting, exercise and diet. You are doing a great service to all of us. 1 Mike McCartney Mike McCartney 3 years ago Wow ..that was an amazing interview. I think I'm going to have to listen a few more times to absorb all this great information. 6 gamblarinn gamblarinn 4 years ago The quality of information and how it's presented is ridiculously good! I'm learning more here than in my Cellular biology class at University. 1 Mickey Mickey 4 years ago love it rhonda! the timeline is an amazing addition by the way, love how you can bounce back and fourth between topics and revisit those that you want to study more 2 Testing Instruments Testing Instruments 5 months ago Wonderful interview for improving one’s health and slow aging. Thanks very much. Rita Fong Rita Fong 4 years ago Dr.Patrick is one of the best interviewers. Fantastic information. Keep up the good work! 1 Christopher Tan Christopher Tan 4 years ago Amazing interview!! Touched on so many subjects and questions about autophagy in regards to intermittent fasting. Blown away by the details and I look forward to the progress of this amazing subject. Galileo Galilei Galileo Galilei 1 year ago Thank you Dr. Rhonda and Dr. Guido. It was very rewarding experience in listening to this discussion. Additionally, the screen notes, slides, and time stamps greatly added to a greater understanding of the topics. I know the effort in producing such post discussion edits and addition of slides is huge effort. This does not go unnoticed and is greatly appreciated. It is unfortunate that other science discussions online do not employ nor engage the audience in such a professional and educational manner. Kelsey Brennan Kelsey Brennan 4 years ago This is so fascinating!!! I'm definitely going to try to start a small fasting group with my friends to do 3 or 4 day fasts. Can't wait for more details to be researched. Mitochondrial biogenesis hollaaaaa 2 Anilix Anilix 4 years ago It's fantastic and I couldn't be more thankful that you,special person, share with the whole community such infinitetly valuable informations. It's remarcable that you share whole interviews full of awesome infos,my deepest regards for all your work and for sharing it with us. I wish you all the best! 1 brian warner brian warner 10 hours ago Awesome interview as usual Rhonda. I’ve been a huge Valter Longo fan for about 7 years and Guido is the only expert I would put in his leaug C B C B 4 years ago This is one of the best interviews I've seen on this channel! Super comprehensive!!!! 4 Jeff V Jeff V 2 years ago Another excellent interview, Dr. Patrick. You maximized this opportunity! Thanks so much to both Docs, and soon I'll be supporting at Patreon. Dan Gregory Dan Gregory 4 years ago Legendary as always, keep up the awesome work Rhonda! Really appreciate your non biased, scientific approach to the information you share. You seem to have constant access to the latest scientific evidence. An idea I randomly just had was to have a "literature review webpage" of sorts, whereby you post 100 words or less (for example) on the strongest scientific evidence for various topics such as autophagy, fasting, caloric intake, CRM's, etc with a focus on what the current optimal approach looks like based on the latest evidence. It would be amazing to have a constantly updated reference guide (maybe every 3-6 months an update) where people can go to see an unbiased literature review essentially. But a lot shorter than a typical review. Hope this is an interesting concept for you. Cheers from NZ! Rock on :) BobbyToGo BobbyToGo 4 years ago Thank you for all you are doing, DRP! This stuff is SUPER IMPORTANT. I've been listening to a good bit from Dr. Thomas Seyfried as of late, too. IzzyR IzzyR 1 year ago I would love to see the next chapter of testing and trails for this study that have accumulated since this interview. Hopefully Dr. Rhonda Patrick can sit down with Dr. Guido soon 🙌🏾💙🙌🏾 thank you for this Kijas Kijas 3 years ago 26:20. Interesting you ask about the Exercise while Fasting. I have been doing 16 hour fasting and find it great for energy (Mental) and weight loss (Fat). Personally I find it really efficient to exercise at the 14th hour for about 30-45 minute run and then eat around the 15-16 hr to break the fast. I no longer have a 3pm low energy and have been loosing weight this way. :) 13 Steven Lohman Steven Lohman 11 months ago I love how this gives me so much information. How great it is to be living in a time with this much information out there and the difference between of opinions on this subject. It’s great!!! chimz 13 chimz 13 2 months ago This is wonderfully done Thank you Dr. Rhonda you’re amazing! John Camery John Camery 3 years ago I found this interview extremely interesting, esp., about the importance of autophagy in using the immune system in the long term suppression of a cancer. 1 August Bernard August Bernard 2 years ago Thank you so much! So much time you must have spent putting all of this together. Pro tip:I watch this on my phone and tablet at the same time so I can pause the pictures and articles. Probably because I’m slow and need more autophagy in my life. 2 Tom Judd Tom Judd 3 years ago Nicely done, even though most has gone over my uneducated head love how you add illustration and definitions et al.Having to educate myself having been recently diagnosed with cll and given NO advice on exercise, diet,just wait and see is the standard. Keep up your good work.Thanx Spencer Forman Spencer Forman 4 years ago Thanks for producing such amazing videos. I have a questions about pregnancy and breast feeding. I feel like science around diet and 'extreme' diets is lacking. Does fasting reduce milk production? Yes... Does a compound that mimicks fasting or a keto diet affect milk production? Shrug. My wife is breast feeding and I would love a video like these to help explain the benefits or side effects of intermittent fasting, low carb, sauna use or eating a bunch of saphanophane (sp. broccoli compound) or spermadine rich foods. Fasting For Fertility Fasting For Fertility 3 years ago wow this guy is excellent. thank you so much for interviewing him!! 2 Søren Markov Søren Markov 2 months ago wow thanks for writing down the biology terms as he was describing this stuff, I really do appreciate that very helpful! eloise sharp eloise sharp 4 years ago Yes, protein depletion has been tested on humans and protein deprivation has been practising for many years, but for the past 25 years in very large numbers at the sanatoriums of Dr Emilova in Bulgaria. Hundreds of thousands of people have been there fasting under doctors supervision and the data shows improving the health of all of them. You say here, we don't know. Yes, we do know. Its documented. And fasting could be done not only for more than 24 hours, but as long as 30 days eating fruits only. My own experience from it is also amazing. Of course fasting should always be done under doctors supervision as some conditions could get worse. 1 John Smith John Smith 1 year ago Fascinating and very important info! When protein management becomes dysregulated thanks to oxidative stress and insulin resistance you get everything from Kidney Stones to Alzheimers to Cataracts! A proper diet that's free of processed carbs should allow us to age much more gracefully with fewer complications. Joe Smith Joe Smith 4 years ago This guy is the real deal. He's got 'skills to pay the bills'. 21 Bibi Love Bibi Love 4 years ago Thank you so much for this interview and for the breakdown. Vera Zheleznyak Vera Zheleznyak 4 years ago (edited) Great information as always! Thank you! I have just started eating natto for its K2 content, but I had no idea about another compound such a spermidin. It is so fascinating! It might create a shortage of natto ...lol Adiudicium 1776 Adiudicium 1776 2 years ago Great interview, thank you both! 1 Jozef Gurzynski Jozef Gurzynski 5 months ago WOW! I mean... That was incredible! To have someone who knows the data so deeply and paired up with someone who knows all the right questions to ask. Even the point about coffee at the end, I thought "Dang, I only drink decaf, I wonder if it'll still be beneficial?" and then that data was given too. And all the information to cover the vocab as the video progressed, the sources and the diagrams! If schooling was taught like this, we'd all be geniuses by the time of high school graduation! I need more of this level of education. So informative, and useful and backed by science. Than you Rhonda! And thank you Dr. Guido Kroemer. This was amazing! I'll start to add some more of those things into my lifestyle; I'm currently on a prolonged fast and wanted to get more information about the benefits to keep me on track. I definitely need to make this a more regular part of my lifestyle! Ah Kin Choong Ah Kin Choong 3 years ago Indeed a very enlightening explapnation of very complex subject. now I begin to understand why in some occasions we tend lose appetite or avoid foods when we are not well. 2 Roger Bird Roger Bird 4 years ago What I care about most is what the good doctor is doing for himself. This what he really believes in; everything else is theory and scientific babble. Exercise, OMAD, two 5 day fasts per year, resveratrol, and coffee. And I am betting that a bitter green smoothie would work better than the coffee, but of course it has not yet been tested, so this would be only for those who can think for themselves and for whom such a tactic would appeal. 4 Virt Real Virt Real 4 years ago I would love to hear his vision about the effectiveness of dry-fasting 1 brian warner brian warner 10 hours ago I would love to know his (or Rhonda’s) opinion on the optimal extended fast to maximize autophagy?? 5 days seems to be the consensus among experts, but as it’s not measurable isn’t that speculative. I see no reason why 7 days isn’t “better” for most or at least many people. particularly this with immune system issues ? . Thanks again. Guido’s awesome! Thrilled about his coffee comments! Smart Cat Collar Project Smart Cat Collar Project 4 years ago Very interesting to see an experiment showing that 1/2 days IF has the same effect in mouses as caloric restriction (although I'm not sure how many food they are fed all in all, 50%, 70% or 100% calories) ! I think this is the first time I hear about IF and a rise in life expectancy. Although I never heard about people doing this 1/2 IF... 5:2 IF sounds the closest fasting mode, maybe 4:3 would be better ? 16/8 sounds much less similar, as the 100% fasting period is much shorter... a whole day fast for a mouse would be the equivalent of several days of total fast for human. Of course there is no warranty the human body would react the same way as a mouse. David Smith David Smith 4 years ago You're really knockin us out with these videos... It's exciting and I'm grateful that you post them. Thank you 1 FoundMyFitness Wildan Wildan 4 years ago Interesting, he's also eating once a day - just like Dr. Nun Amen Ra who claims to strongly induce autophagy by fasting 23h every day. I'm on his regiment for about 3 months now, but only recently with caloric restriction and I do notice several positive effects. 4 rationalmuscle rationalmuscle 4 years ago Great stuff, as usual. And btw, pregnancy becomes you! Congratulations to you both. supernova1976 supernova1976 4 years ago There is a study clearly showing IF is having the same effect on lowering igf1 as 4 day continues fasting once a month . Another amazing inligtining interview , thank you so much. 5 Heliolisk Fire Heliolisk Fire 10 months ago I studied Biochemistry in college. If anything, all those many classes I attended a decade ago had let me, now, enjoy and follow this wonderful discussion. Even without fancy editing or diagrams, Dr. Kroemer talking so eloquently in his German accent more than makes up for it. Thank you for sharing. ECR-9 ECR-9 3 years ago My thinking is that Dr. Patrick is pretty humble. I feel fortunate every time I watch one of her videos on whatever subject I have ‘searched out.’ She’s like a modern-day Leonardo DV that we get to watch on you.tube🇺🇸 3 Altero Altero 4 years ago Thank you for such an insightful interview and information! Durian was mentioned. Just curious how this "king of fruit" can influence our health. I know it's very complex and rich food but that agent producing strong smell as I've heard in this interview could have some benefits (or not). I'm sorry that I didn't get it clear from this video. 1 cdawgmetal cdawgmetal 4 years ago Hi Dr. Rhonda am very concerned with my sleeping lately I've been Intermittent fasting for 3.5 years now, been doing a general 16/8 fast schedule eating mostly keto until dinner. I seem to be waking up around 2-3 am everyday for at least 6-10 months now if not longer. I feel great and rested everyday but am super concerned with the fact I can not sleep more than 5 hours, and we all know how important 7-8 hours sleep is. Am I no longer in need of 8 hours sleep? or should I be concerned with deficiencies? I've been obsessing with what i may be missing nutritionally, magnesium, vitamin D, Zinc nothing seems to be getting me a full 8 hours straight sleep. Your thoughts? 2 Drue Fit Drue Fit 4 years ago Awesome video, very informative! 4 Heir Heir 2 years ago (edited) Japanese scientiste Yoshinori Ohsumi has descovered the autophagy/self-eating or destruction, and he has obtained Nobel prize for that descovery which consist on how cells recycle their content. 2 Playthrough & Review Playthrough & Review 4 years ago Maybe I haven't heard it yet- but do you not consume any form of dandelions? The leaves are incredibly nutritious, the roots are great as well. I'd love to hear you talk about them :) 1 J. Hanley Smith J. Hanley Smith 4 years ago Amazing! I started it over right after it finished playing. Thanks Dr. Patrick 1 FoundMyFitness Lipzig Schweitzer Lipzig Schweitzer 4 years ago I'm going to start watching these videos with a notebook. God damn I love this channel! Thank you for making me smarter for free Dr Patrick, I and my family appreciate it very much. 19 FoundMyFitness Jason Cazes Jason Cazes 5 months ago The way Dr. Kroemer pronounces autophagy is borderline ASMR. I could listen to 9 more hours of this. Jerry Moostache Jerry Moostache 4 years ago That baby is gonna be immortal 386 Royal Royal 4 years ago Definitely watching this when I get out of work. Thank you Dr. Rhonda!!! 1 FoundMyFitness DenisMguitar DenisMguitar 3 years ago awesome geeky informative motivating discussion. Thank you. Eviya Eviya 5 months ago Rhonda, pls also consider recording a video on autophagy and virus infections. I have EBV virus, and available studies unfortunately show that fasting is not favourable in such environment KarolinaKS KarolinaKS 4 years ago Congratulations on your pregnancy!! wish you all the best!! 2 FoundMyFitness Aly Joseph Aly Joseph 4 years ago Do you know how healthy this baby is going to be with a mom like her? It's going to be in a sauna In no time! 114 FoundMyFitness Akuma Akuma 4 years ago This is just brilliant. 10 FoundMyFitness Deepa Jain Deepa Jain 3 years ago I listened twice and rewound, several complex sections and was still left a bit confused at the end. But in another Dr. Patrick video, they noted even black coffee starts metabolic processing, so it isn't truly fasting. Anyone comment on this distinction please? 1 lmanarao vaniggalla 3 years ago Good subject. Thanks Dr.👍👍 T. Steve Quach 3 months ago Hi Rhonda. Love your video!. Do you know what is the best supplement brand of spermidine? or How do you increased your spermidine intake naturally? George Wachsmuth 4 years ago Another excellent video. Thank you. Si mon 4 years ago this is such a great video! thank you so much. PookieNumnums 4 years ago You're looking well! The world needs the info you help share, tyvm for your efforts! Pyriphlegeton 4 years ago Very interesting talk, thank you. 4 Robert Mertens 8 months ago (edited) Like at least one other commenter, down below, I fast 15 - 16 hours every day. My morning workout comes just before breakfast. Except, I've been doing this four years. I'm almost never hungry, no matter what time of day, and at 67, I don't have much gray hair (which is said to be caused by senescent cells around the hair follicles). As Dr. Ohsumi said in one of his lectures, during complete cellular autophagy, about half the cells consumed are healthy and about half are unhealthy (usually senescent). And as we all believe we know, senescent cells are the bad guys. The body keeps cells around that it would normally kill and eat. But if the body isn't hungry, it keeps these for a snack "later." Very often, "later" never arrives. I don't like working out after a meal, so I work out in the mornings, before breakfast, when my stomach is fairly down to empty. I always have tons of energy and more to spare. I'm also deeply engaged in a ketogenic diet (low carb, low protein, high fat). I'm surprised, over the last four years, that the more fat in my diet, the more weight I've lost. It also appears that, if you don't give your body enough energy to function, it will break down protein and turn it, essentially, into carbs. One day recently, after a bike ride, a friend pulled out some meaty treats (slim jim style - I said they look like doggie treats) and offered me some. I mansplained this to her and said, "you may as well be eating potato chips." She said, "Nu uh." I said, "Uh huh." And that went on a few rounds. But we know that carb burners need energy every two hours or they get hungry. Fat-adapted folk can go for a fairly long while (days, weeks, months) without food, and never get hungry. At the end of a 16 hour fast, you're burning fat (there are no carbs left in your stomach to burn). My most recent blood tests were pretty amazing, so I'm fairly enamored of this diet. I'm always eating the tastiest, fattest, richest, saltiest delicious diet imaginable (I use potassium-sodium 50-50 salt), with almost no carbs, and somewhat low protein. I only eat two meals a day and they're fairly small. I can't seem to fit a third meal (lunch) in. It's just breakfast and dinner. 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