NAD+

NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide 476,603 viewsPremiered Jan 28, 2020 13K DISLIKE SHARE DOWNLOAD CLIP SAVE FoundMyFitness 421K subscribers In this episode, Rhonda explains what NAD+, why it is so important for aging and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, what animal and human data says and some concluding thoughts. NAD+ is crucial for our survival. Small amounts of it can be obtained in the diet, but the body recycles it to get most of what it needs. Unfortunately, day to day living plus normal aging can cause NAD+ levels to drop. This causes metabolic and mitochondrial dysfunction, as well as many of the other problems and conditions associated with aging like elevated DNA damage. NAD+ levels can go up when we exercise or fast, but NAD+ precursors like nicotinamide riboside and nicotinamide mononucleotide can also increase NAD+ levels in a dose-dependent manner. However, most of the data on NAD+ boosters comes from animal studies. Whether these boosters are effective – and safe – long-term in humans is still a big question. ▶︎ Get the episode's show notes, timeline, and more https://www.foundmyfitness.com/episod... Chapters 00:00:00 - Introduction 00:01:01 - Aging 00:02:47 - Overview 00:07:35 - Depletion 00:09:19 - Supplementation 00:11:26 - Animal studies 00:13:47 - Cancer 00:15:57 - Dosage 00:25:44 - Human data 00:28:25 - Storage 00:29:00 - Recap ▶︎ Detailed overview of NAD+ https://www.foundmyfitness.com/topics... ▶︎ Detailed overview of nicotinamide riboside https://www.foundmyfitness.com/topics... ▶︎ Detailed overview of nicotinamide mononucleotide https://www.foundmyfitness.com/topics... ▶︎ Did you enjoy this podcast? If you want to support me in getting more of this free information out to the public, please consider becoming an FMF premium member! In doing so, you'll also get access to exclusive member benefits, such as a private podcast feed offering early access and occasional bonus episodes, monthly live Q&As with me, a members-only library that includes presentation slides with all of the supporting figures, graphics, references, and quotes. Also included are Rhonda's private notes on topics discussed in the podcast, bi-monthly member-exclusive Science News Digest email, and more. Thank you for your consideration! Learn more here: https://www.foundmyfitness.com/premium ▶︎ Gain valuable insights by running your raw genetic data through the FoundMyFitness report https://www.foundmyfitness.com/geneti... Chapters Introduction 0:00 Aging 1:01 Overview 2:47 Depletion 7:35 Supplementation 9:19 Animal studies 11:26 1,246 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 2 years ago (edited) 00:00:00 - Intro. 00:00:48 - Nicotinamide riboside supplementation in humans has been shown to raise NAD+ levels in white blood cells. 00:02:47 - Overview of NAD+ 00:05:12 - NAD+ plays an important role in mitigating DNA damage. 00:05:30 - Excessive DNA damage can decrease NAD+ levels by 20-30%. 00:05:42 - Lymphoblastoid cells from centenarians show increased PARP-1 activity. 00:05:55 - Between different species of mammals, higher PARP-1 activity is strongly associated with a longer lifespan. 00:06:36 - Lower organism evidence: A second copy of SIR2, a yeast sirtuin, gave rise to a 30% extension of lifespan. 00:06:43 - NAD+ is required for the activation of sirtuins, which epigenetically regulate a variety of stress response-related processes. 00:07:03 - Energy stress, such as from fasting, exercise, or caloric restriction, increase the NAD+:NADH ratio. 00:07:37 - NAD+ becomes depleted in the brain, heart, and skeletal muscle as we age. 00:08:13 - Decline in NAD+ levels have been associated with many broad categories of clinical disease such as neurodegenerative, cardiovascular, infectious, musculoskeletal. 00:08:48 - NAD+ supplementation has been shown to increase lifespan in models of aging in yeast, worms, and rodents. 00:09:48 - In contrast to de novo synthesis, the predominant source of NAD+ in the body is via the salvage pathway, which is subject to feedback inhibition by nicotinamide. 00:11:56 - Animal studies have shown nicotinamide riboside supplementation is able to increase insulin sensitivity, increase endurance and strength, reverse mitochondrial damage, increase mitochondrial biogenesis, and reverse muscular atrophy. 00:12:30 - Nicotinamide riboside has shown positive effects on the brain in animal, such as increased neurogenesis, decreased cognitive deterioration, decreased amyloid-beta production, and increased synaptic plasticity. 00:12:50 - Nicotinamide mononucleotide has been shown in animals to counter an obesogenic diet, improve markers of metabolic health, improve heart function, and improve cognition and memory. 00:13:10 - A 12-month dietary study of nicotinamide mononucleotide suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies in mice. 00:13:47 - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice. 00:15:57 - Plausibility of dosing: comparing animal and human doses. 00:18:05 - Tissue-specific metabolism and bioavailability of NR and NMN. 00:24:32 - Oral administration of NAD produces NR and NMN in the intestine. 00:24:19 - Intravenous administration of NAD, rather than its precursors, shows interesting results: an increase of NAD content and sirtuin expression in the hypothalamic region of the brain. 00:26:15 - Human study #1: 250mg of NR + 50 mg pterostilbene increased blood NAD+ levels by 40%, while a double dose (500 mg NR + 100 mg pterostilbene) increased blood NAD+ levels by 90%. Additionally, there was a decrease in blood pressure, and ALT (a marker for liver health). 00:27:12 - Human study #2: 500mg NR twice daily for six weeks increased NAD+ levels in white blood cells by 60%. 00:29:08 - Concluding thoughts and recap. 248 pablopolski pablopolski 2 years ago Concise, comprehensive, and articulate. I don't even need to speed it up to get through the information. Well done. 367 FoundMyFitness Chuck A Chuck A 2 years ago Congratulations Rhonda you have smashed the record for total mentions of "Nicotinamide and Nicotinamide Mononucleotide" without stuttering, giggling or entering a comatose state. Kudos! 178 Chris Benton Chris Benton 2 years ago Excellent lecture, well put together, a good balance of pros and cons, useful diagrams and a clear summary at the end. Perfect presentation technique. 109 FoundMyFitness Rich Rozmarn Rich Rozmarn 2 years ago Great presentation, thank you so much. I take NAD with R-Lipoic acid, D-Ribose and Resveratrol for a pre workout. I work out 3-4 times a week and feel as good as when i was 40, now 60. 48 DAVID EVANS DAVID EVANS 2 years ago (edited) Rarely do we find in the study of nutrition, detail like presented in this video, yet at the same time Rhonda is able to get to her final conclusion without leaving everyone in the weeds. Extremely well done. Combined with Dr. Nicholas Pericone and Dr. Jason Fung, we are starting to get a handle on what is necessary to make critical changes in our life for optimal health... 5 Dr. Nancy McClure-Galli Dr. Nancy McClure-Galli 2 years ago So great to have the micro cellular pathways broken down this way. Also, the analysis of both animal and human studies. Thank you so much for the effortless way you explain potentially mind boggling processes. Helps so much in the decision making process. Scott Joshua Scott Joshua 2 years ago What a herculean effort and a testament to your ability to grind it out for hours on end. You’re incredible Rhonda. 14 FoundMyFitness No Limit No Limit 2 years ago A very professional very well presented lecture . English is my 4th. language and I did not have any real problem to understand it and learn from it. Doc, I really appreciate your effort to create this video. Thank you. 5 FoundMyFitness Cat Man Cat Man 1 year ago I've been taking a low doseage of NMN for a couple of weeks now. I started with 100mg in the morning and 50mg at night on the first day, then 50mg the next morning. I hadn't been expecting any results for at least a week or so. About 2 hours after taking that second morning dose I went out shopping and was astonished to find my legs wanting to walk faster and faster, as if under their own volition. I've not walked like that in almost 7 years. I've had a number of strokes and suffer numerous symptoms, manly to do with inhibitted activity levels. My mind is foggy most of the time and the NMN has not done anything for that, but I certainly feel the difference in energy levels, it's really amazing. I also found that after a few days I had to stop the NMN for a couple of days as it seemed to be making me feel more groggy, so I now take it 2 days on, 2 days off. The brand I'm using is an American Brand called RevGenetics, and it's called Advanced NMN, in capsule form. I know it's also available in powder form too. It's quite expensive even in capsule form and would cost the earth to take it regularly at the doseages recommended in this video, but I can assure anyone that the effects at the doseage I am on are truly amazing. 1 Tony Westbrook Tony Westbrook 2 years ago I learn so much here by your presentation and documentation. Thank you Rhonda for taking, what must be a lot of time to put all of this documentation together! 27 FoundMyFitness quigonreturns again quigonreturns again 2 months ago Hello! Would love to know your thoughts on methyl group depletion as it relates to Niacinamide supplementation. I have been taking it at 500mg/day, with no ill effects. However, I am cautious about the long term affects of supplementation. Thanks! And love your content! Dustin Phillips Dustin Phillips 2 years ago Thank you for the video. I have been taking Tru Nigen (NR) for about two months at 350 mgs. What I have noticed is a slight increase in energy, and focus. I feel like I have also lost some body fat. However, I stay in Ketosis and use intermittent fasting 4 days a week. However, I plan to stop taking it once my bottle runs out because of the information presented in this video. I don't see the benefits outweighing the potential downsides. Thanks again. 10 profitfever profitfever 2 years ago So glad you covered this. Been listening to lifespan on audio book and he's one of the leading scientists on this research. 8 David David 2 years ago Great video Rhonda, thank you for all you're doing and the quality information with such strong scientific detail. 2 N C N C 2 years ago I've been doing lots of reading and this is by far the most in depth breakdown I've seen on NR/NMN yet. While I am really impressed with anecdotal evidence of NAD supplements, I am erring on the side of caution. Personally, I'm going to hold off on purchasing supplements until more clinical trials come out so we know proper dosages and whether or not this even carries over from mice to humans. Anyone else feel the same way? If it turns out this is safe, easily replicates in humans etc then I will consider supplementing. 1 Ramon Mensink Ramon Mensink 1 year ago Great video Rhonda! I was wondering if it makes sense to take a NR/NMN supplement while also ingesting carbs/protein/fat. As you also explain in the video, the NAD/NADH ratio in the cell increases when fasting/CR/exercising. Then such a NAD boosting supplement would need to be taken in a fasted state wouldn't it? Or is the pathway of either NR/NMN supplement somehow separated from the metabolic pathway when a cell is in a fasted state? 1 Steve Wright Steve Wright 1 year ago Many thanks for this detailed walk through! I think correctly identified this is all at an early stage of discovery - perhaps usefully highlighting the key importance of NAD in the cell energy economy, but (to my mind) now pointing to the need to reduce NAD depletion. A whole food plant based (WFPB) diet being inherently low inflammation - perhaps best indicated by White Blood Cell count: https://nutritionfacts.org/video/what-is-the-ideal-white-blood-cell-count/ Also points to a need to remove senescent cells regularly - probably by a number of 5 day water fasts over the year. Lastly - not a bad shout to pay attention to Vit B3 status - if this is insufficient NAD production is likely to be throttled... Thanks Rhonda for this review - appreciated! KenG KenG 4 months ago Excellent analysis and much appreciated! I love your presentation speed and style! 1 Harvey Holloway Harvey Holloway 2 years ago Great video. I am 70 and a health fanatic, and still in perfect health. I have a massive coordinated program that did not include this. Now I will be going out today and buying Niacin. I am going to start immediately. Have a wonderful day. ☺😎🐰 4 Rob Lovegreen Rob Lovegreen 2 years ago Because of you, I started loving myself with broccoli sprouts. ❤️ I grow them too. Sulforaphane for the win! Thank you 🥦 59 Morrocco Method Int'l Morrocco Method Int'l 2 years ago So helpful + informative for learning about aging. Thank you for this video! 2 Joseph Khadige Joseph Khadige 1 year ago Great presentation Doc. Thank you. Please excuse my ignorance in this matter but to make sure I am understanding it accurately, if a cancer patient is regularly fasting and exercising (which leads to increase of NAD levels) would that increase the spread and developing of the cancer cells? SpockBoy SpockBoy 2 years ago (edited) Thank you so much for bringing us this information Doctor. Using your great intelligence for altruistic purposes is both rare and wonderful. 3 gururaj bsavakar gururaj bsavakar 2 years ago Congratulations! Firstly for the , pleasant, patient presentation, with amazing revelations of test results of NAD, decline with age, using boosters of NAD, & Alternate pathways which work usually but with exceptions!!! Extremely A Great MASTERLY STUDY/ & presentation of all pros- cons of all eventualities . With a final recap!! Thanks for this useful educative share! Many regards! 4 FoundMyFitness Cris Clourt Cris Clourt 2 years ago Thanks Rhonda for your amazing research! Do you know what type of trans-resveratrol is best? Does it have to be organic etc...? 2 jackwelshh100 jackwelshh100 2 years ago (edited) Very interesting episode. Fantastic work! One question comes to mind: We know that resveratrol is a SIRT-1 activator but are there identified compounds that increase PARP-1 activation (for us with non-supercentenarian genes)? I supplement with NR and resvetral. If there's a PARP-1 specific activator compound, it might be an interesting addition to the mix. 4 Andrew Moore Andrew Moore 1 year ago Superb. So much information explained so efficiently in 30mins. I feel very well informed now, thank you! 1 Gregory Colvin-Garcia Gregory Colvin-Garcia 1 year ago Rhonda, I've heard Dr. Sinclair say he takes 1gram of NMN daily but in reading his book and listening to multiple interviews I'm not sure on the best time metabolically to dose and if there is a "minimum effective" single dose. Currently, I take 250 mg, 3 to 4 times per day sublingually but it occurred to me that each one of these single doses may be below the threshold of effectiveness... 2 B Szlado B Szlado 2 years ago Great summary of the topic! I was desperately trying to find actual human published data about NAD+ decreasing with age, but other then the two studies you mentioned, couldn't find much. In those two studies though, sertuin activity actually didn't decrease; there was significant difference between men and women, and the NAD+ decrease was extremely small (vs. the 50% David Sinclair commonly mentions), and in fact looking at the graph, it was quite variable, with some 30 year olds having the same level as 60+.. .so I really wonder if the marked "decrease" in NAD+ everybody goes on and on about is actually a comparison of an active 20 year old vs. a sedentary, unhealthy 50-60 year old; ie. isn't the life style more important than the horrendously expensive NMN and NR supplements? Karla Jean Karla Jean 1 year ago 5 months later and I'm still coming back to relisten to this video. Very informative and so well put together. 2 Vedran Simic Vedran Simic 2 years ago Very interesting. From your video's from Satchin Panda I learned the benefits of time restricted eating regaring insulin sensitivity, sleep, cardiovascular aspect etcetera. Do you have any information whether NAD+ increases also with time restricted feeding and which window of eating you should use? Or is there only information about fasting and increasing NAD+ and if that is the case how long you should fast for increasing NAD+. 1 a2audrey a2audrey 2 years ago I’ve been taking 750mg of NMN + 500mg resveratrol for 6 months. I’m 61 and in good, but far from great shape. My muscle stamina and overall energy are way higher than when I began. I also have noticeable reduction in inflammation in my leg that was damaged in an accident and where it had been chronic for many years. The reduction in inflammation alone keeps me on it, but feeling a lot better is great too. 42 Kuo-Ying Wang Kuo-Ying Wang 4 months ago Excellent and brilliant work. Thank you very much indeed. The literature reviewers are amazingly detailed and strikes the key points of the findings from the researches. Ken Otwell Ken Otwell 2 years ago Great data - but leaves me with one big question - how much does exercise increase NAD+ and how does that compare with supplementation? Also - is there any synergy between exercise and supplementation? 64 Ja Wi Ja Wi 2 years ago Good work! You certainly did the research and can explain it with great accuracy. Thank you. pravoslavnik pravoslavnik 2 years ago Just found your channel/videos. Your presentations are "spot-on," as the modern expression has it. Loaded with information. Love your vids. I shall be watching them all. PLEASE keep up the good work ! 2 FoundMyFitness Noveleffect Noveleffect 2 years ago I really appreciate the chemical reaction explained to me along with the reaction diagrams. So rare to find anything this thorough 4 Cuenta de Youtube Cuenta de Youtube 2 years ago Best unbiased recap of NAD+, NR and NMN. Thank you! Suscribed! 3 Tom Provan Tom Provan 2 years ago This is definitely the best most informative and comprehensive piece of information so far delivered on this topic as far as I am concerned thank you for this video Wolfram Luchner Wolfram Luchner 2 years ago Exemplary summary. I love how dense with information your videos are. Quite a rarity on youtube! Keep up the good work and thank you for your high quality content! 7 FoundMyFitness uncle Joe uncle Joe 2 years ago Exciting developments. Great to know scientists are working so hard on our behalf in this crazy world. In the meantime I'll continue my exercise, sauna, and clean diet. Thanks! 1 alfred Vincent alfred Vincent 1 year ago Great concise presentation as always. Thank you. 2 Roger Bowman's Fitness & Wellness Coaching Roger Bowman's Fitness & Wellness Coaching 1 month ago Stellar presentation as always, thank you Dr. Patrick! Aldous Orwell Aldous Orwell 2 years ago Beautiful! Very comprehensive! Question: does DNA repair have a circadian rhythm? If so, would it be better to take NR in the evenings? Thank you! :-) Jeff G Jeff G 2 years ago Great video. Now I'm wondering how long it will be until we have solid data on positive effects as well as dosage sizes and methods to experience those effects. Years? How many? Equs Narnd Equs Narnd 1 year ago I'd like to see you do a video on the role of Niacin (Nicotinic acid) on supplying the molecules for the manufacture of NAD+ 11 June Allison June Allison 1 year ago Dr. Rhonda this is the best explanation I've heard on this topic. So thorough and well thought out. Thank you❤ 2 Larry Tate Larry Tate 2 years ago Dr. Patrick thank you for sharing your knowledge. Could you please consider doing a video lecture on CBD and it’s benefits and possible negatives? Thank you B D B D 7 months ago (edited) Excellent!! Conclusion: Fasting, less calories, regular exercise increases NAD level👍 We all need to wait for using supplement at this point till more data available! Bakhtiyar Neyman Bakhtiyar Neyman 2 years ago Instantly one of my favorites videos on Youtube. Thank you so much, Rhonda! 2 carpe diem jonah carpe diem jonah 2 years ago (edited) So what are the best relative food sources of NMN? And the best relative food sources of Nicotinamide Riboside? Are some of these foods significantly higher in their capacity to boost NAD levels? Hoping to get it aboard the food supply so there is the safety of letting the body metabolize as needed. Optimize with Science Optimize with Science 2 years ago It is a fascinating topic and I love how scientific Dr. Patrick approaches it! 41 FoundMyFitness Konstantin Yavrichev Konstantin Yavrichev 1 year ago Congratulations 🎊 - It's pretty rare to be able to see such good quality presentation for so complex topic and compressed in so condensed time 1 Casey Connor Casey Connor 2 years ago Fantastic as usual! Thanks for the great information! Hey, if you get a chance to circle back on the subject of eating fresh ground broccoli seeds at some point that would be great. Many of us like the taste of them! Or don't notice it when added to food! Erucic acid might be a consideration? Thanks! 2 Dan O'Hanlon Dan O'Hanlon 1 year ago Very helpful — comprehensive — much appreciated! 2 Ivan Valdez, PhD Ivan Valdez, PhD 8 months ago Fantastic job, Dr. Patrick. Do you think that sublingual NR/NMN would be effective at increasing NAD+ levels in different tissues And not just blood, similar to Intravenous administration, by bypassing the liver? Rick Kowalchuk Rick Kowalchuk 2 years ago It seems to be a key component involved in aging and possibly reversing the process! C H C H 2 years ago (edited) Regularly growing broccoli sprouts for a couple months now, I put them in my daily smoothies for myself and my family thanks to Dr. Rhonda Patrick. Thank you for all this free info, truly is life changing 36 FoundMyFitness David Alzate David Alzate 8 months ago I guess in the section on depletion, it's important to include the studies of CD38, CD157, and PARP. These molecules are impacting the depletion of NAD+. Isabella Holden Isabella Holden 2 years ago Amazing video. Thank you for the brilliantly explained content.🇿🇦😎🙏 4 FoundMyFitness rzomg rzomg 2 years ago Amazing skills to flood my brain with huge amounts of information. I know how its gonna feel when AI's are smarter than us all its the same feeling I get when I listen to Dr.Rhonda 2 Ron RG Ron RG 1 year ago Dr. Rhonda amazingly insightful analysis of the data! Love the topics and videos you make . Thank you so much 1 Dr. Steve Hruby, D.C. Dr. Steve Hruby, D.C. 2 years ago Thank you Dr Patrick this is above and beyond anything that is out there. 1 FoundMyFitness SmartCookiesDontCrumble SmartCookiesDontCrumble 1 year ago Thank you so much for giving this teaching on this topic. Valuable information!🥰 2 Christina Lawhorn Christina Lawhorn 2 years ago ** Due to a serious case of mold poisoning I have been on NAD+ IV's for 6 months... they literally saved my life.. I have never had oral NMN or NR. However I would highly recommend anyone with a health issue try NAD+ IV's. There are numerous accounts of people turning their life around due to NAD IV's not precursors. Best wishes to each of you! 1 firehorse_44 alpha-omega firehorse_44 alpha-omega 2 years ago Excellent lecture. Thank you for this presentation Dr. Cheers 10 Ro Bo Ro Bo 2 years ago Wow talk about informative video thank you , I’ve been taking a product which contains Nicotinamide 250 mg twice a day with botanical mix alpha lipoic acid vitamin c and zinc which apparently works on the salvage pathway you have described. The company claim that Despite all the hype surrounding the use of precursors such as NR and NMN to boost NAD+, our cells actually make nearly all of the NAD+ they need using NAM ,as you described in your presentation. They go on to say That “as we get older, levels of the NAMPT enzyme are known to decline and the salvage pathway becomes inefficient at converting NAM into NAD+. In fact this is known to be one of the main reasons that cellular NAD+ declines as we get older. This means that if we want to make sure that NAM doesn’t build up in the cell, then we must make sure that NAMPT and the salvage pathway are working optimally, like they were in young cells. Rather than simply trying to fix falling NAD+ levels by putting more raw material into the cell (using precursors) the product is designed to fix the underlying reasons why NAD+ is actually declining, namely the failing salvage pathway. I am however concerned of the effect of Nicotinamide on sirt2, they claim however that Nicotinamide does not effect sirtuins if it doesn’t hang around for a long time when the salvage pathway is working properly . I just wondered what your thoughts are on this. Again many thanks for your very detailed video 2 Entropy Wins Entropy Wins 2 years ago I'd be interested in a video on pterostilbene and thoughts on supplementing that. Thomas 3108 Thomas 3108 1 year ago Hello, I have one problem taking NMN. Hope you can help with your knowledge 😃🙏 I take 0,5 - 1 gramm Resveratrol in Oliveoil, 0,5 gramm of NMN and 1 gramm of TMG. I started taking TMG as I noticed, that after about 3 days I feel a certain pressure on my heart or let's say on the left side of the breast and I feel like having higher blood pressure. Then I stop the life extension treatment and everything is fine again. When I take only Resveratrol or only TMG this phenomenon doesn't appear. I thought with taking TMG this would stop, but that's not the case. After starting again the same reaction appears. I bought NMN even from Prohealth. The same thing. The dose is really not that high, so I am wondering as the studies don't have such results. I am 45, 1,75 m and about 83 kg. So what's your opinion on that? Thanks in advance, Thomas 1 AJ Hege AJ Hege 2 years ago Appreciate the info! What are your findings about NADH (NAD bonded with a hydrogen ion)? I hear it has a better delivery system from a doctor on the Ben Greenfield podcast. Chad Aitken Chad Aitken 2 years ago Thanks for the effort on the video. Can anyone get the Parp-1 activity level test? Do we know what happens in the Salvage pathway recycle that lowers levels as we age? I seen reports that % gains is not good enough in older people since it’s so low? Dr. Michael Moeller Dr. Michael Moeller 2 years ago I personally get NAD IVs@24:30 and use them with my patients and notice an increase in energy and improved cognition. 31 Kunverji Hirani Kunverji Hirani 1 year ago Hi Rhonda :-) So practically, what do you recommend? Take NMN first thing in the morning? - then how long should you wait before having breakfast? Or can you have breakfast straight away after taking NMN? Many thanks :-) MrVeteranhawk MrVeteranhawk 5 months ago I did 10 push ups for every time she said NR or NMN, I don't have to workout until the year 2023 now..lol. But great presentation, very helpful for my age at 52. I've been doing a lot of research on taking supplements to increase NAD+ 1 Stephen Hurst Stephen Hurst 1 year ago Thank you so much for the thorough long-form video, all of this information is very important. 1 McJagger McJagger 1 year ago I started taking 250-500mg of NMN sublingually for a few days and felt really great and energized, but then it suddenly started making me exhausted and sleepy. This happened within 1 week’s time. It caused my grandmother on first usage to sleep all day after taking it in the morning. I can’t find much info on this effect. Waskel E. Wabbit Waskel E. Wabbit 1 year ago (edited) I have been taking 300 mg a day of NAD+ for almost a month. Took about three weeks before I started noticing a difference. It is very subtle but that might be a good thing. There's a fine line between feeling like doing something or not. I have had chronic fatigue for all of my adult life. I am 68 now. Been looking for the magic pill for that long. Getting ready to order my second bottle and I would recommend to anyone with low energy levels or just to possibly live longer. No one I've talked to has heard of this stuff. Would like to get some friends to try it to see if it helps them too. 1 Anh Nguyen Anh Nguyen 2 years ago Thank you for such an educational clip . Please keep it up 3 NADIOL™ NADIOL™ 7 months ago Amazing content as always Rhonda. B K B K 2 years ago Amazing video, thanks for the in depth overview! I've been following NMN for a while now, and this is the best video I've seen to date, covering every aspect, concisely. Absolutely amazing. Now if only supplimenting NMN wasn't so cost prohibitive. 😅 I'm up for being a long term study if anyone needs a test case. 🤔 I've got about two years worth of detailed food logs, heart rate, sleep logs, weigh ins, blood work, exercise, and the likes, that I'm farming up anyway as part of my commitment to getting fit. I wouldn't mind sharing with actual doctors and scientists. 😋 🤷‍♂️ Either way, thanks for the awesome info! GLHFDD! ✌️😈 7 Josh Woodle Josh Woodle 2 years ago (edited) Dr. Rhonda, since Dr. Jed's video, I've been eating just the broccoli seeds. Is there any way you could do a video on consuming broccoli seeds vs. sprouts? I burr grind them and sprinkle over food. Very interested in this! Bart Bart 2 years ago Thanks for the good video! I was wondering where is the source for the statement that NAD is lower in older human muscle compared to young. Does this data exist? 2 Nathan Nathan 2 years ago Great video, thank you for quality information! 2 Erin Greer Erin Greer 2 years ago Thanks for so much important information. I hope more studies in humans are coming. Launch Medical Media Launch Medical Media 1 year ago