Introduction to epigenetics 95,527 views Dec 5, 2018

Introduction to epigenetics 95,527 viewsDec 5, 2018 Pine Biotech 10.9K subscribers This course is a part of a series of bioinformatics modules designed to introduce biologists to analysis of various omics data types. Learn more: https://edu.t-bio.info/course/epigene... Epigenetics refers to mechanisms of gene expression regulation that do not involve changes to the underlying DNA sequence. At least three systems including DNA methylation, histone modifications and non-coding RNAs (ncRNA) are considered to play fundamental roles in epigenetic regulation. Epigenetic regulations play an important role in a variety of human disorders and diseases. In addition, age, environment, lifestyle, and other factors influence epigenetic states. Epigenetic regulation of gene expression has been linked to discrete mechanisms that affect the stability, folding, positioning, and organization of DNA. The most studied of these mechanisms includes DNA methylation and chromatin remodeling, which work synergistically to organize the genome into transcriptionally active and inactive zones. To better understand the bioinformatics approaches to studying the epigenetic changes in cells, it is firts important to understand the biology and the molecular assays that are used in researching these regulatory mechanisms. Chapters Epigenetics is 2:34 On the Way From Code to Function 2:48 The Epigenome: DNA 3:45 DNA Methylation 4:37 Histone Modification 6:11 Chromatin Packing 7:42 70 Comments rongmaw lin Add a comment... a i a i 1 year ago Thank you , this was one of the best explanations I have ever seen 7 Savannah Wright Savannah Wright 9 months ago This was very helpful, thank you! 2 Titi Titi 3 years ago Very well explained! 7 krishna kumar ganta krishna kumar ganta 1 year ago Holy.. He is not a biologist by education but he is the best at what he teaches. Thank you Elia 4 UHFStation1 UHFStation1 1 year ago Any animations of epigenetics transfers when cells divide? 2 J e J e 6 months ago At about 4.47 you refer to cytosine as an amino acid, maybe just ad a square saying "nitrogenous bases". Great clip! Thank you 2 Mike Jones Mike Jones 1 year ago I have a question that isn't quite related to epigenetics but more to something you mentioned-- You said that Chromatin Packing has a governing effect on processes including apoptosis. How could this be the case? Do cells willingly undergo apoptosis or is it the same thing as lysing the cell itself? I've only heard the word apoptosis used in the context of osmosis from a hypotonic(I think) solution being an environment in which cells will explode. Álvaro A. Lorite Álvaro A. Lorite 1 year ago I was under the impression that it was recently discovered that methylation has inherited to some extent. 1 Bobby Poly Bobby Poly 2 years ago If you call that an intro to epigenetics, than i think i need an intro to the intro😉 64 Ola Ayman Ola Ayman 10 months ago Thank you ,what about non coding RNA? 1 Edwin Majnoonian Edwin Majnoonian 1 year ago Why when something can't be explained, the next chapter is named "EPI"? Why not modify the genetic principles, instead of opening a new chapter? Fahd Alhamdan Fahd Alhamdan 2 years ago FYI Cytosine is NOT an amino acid! 12 Gehad Mostafa Gehad Mostafa 1 year ago Very helpful 👍 Need I link for I rest of videos Stephen Leighton Stephen Leighton 2 weeks ago Question..... can anyone explain or give clarity on the following ... does any change to typical Purine & Pyrimidine, folate, B6 or B12 pathways during pre or early post natal periods result in heritable genetics that could be passed from that baby should they procreate in later life? 1 Bashar J7 Bashar J7 2 months ago what are the resources you used in this explaination please ? 1 Joe Dart Joe Dart 2 years ago This mono-tonal recitation of a poorly written textbook is more confusing than helpful. This format might be ok for someone reviewing epigenes, but as an introduction to a newbie, not so good. And it is a pity since whoever created this did a lot of work. I feel bad writing this public criticism, but this is more helpful to you than a glowing compliment. Another thought you might consider is to only put up images that make a specific point. Textbooks are stuck having to fit the text and images together, but a living narrator has the choice of what images to show the audience. By synchronizing the narration and images, difficult ideas can be clarified much better than they can be on a printed page. Bottom line... look at this presentation as a two pillar approach to understanding concepts... and make sure both pillars are working together. Thankfully there was no music. That would have made it unbearable. 3 Miss Salma Miss Salma 10 months ago I like to make my speciality epigenetics and I really have no idea which program its part of I didn't finish my high-school yet and interesting these things plz anyone can direct me which courses and programs should i take and which faculty should i join so i can take epigenetic as my major ?? thanks you 0:32 / 16:43 Epigenetics - our bodies' way to change the destiny written in our DNA | Moshe Szyf | TEDxBratislava 256,188 viewsOct 3, 2016 5.3K DISLIKE SHARE DOWNLOAD CLIP SAVE TEDx Talks 35.1M subscribers What we thought of as something fixed, DNA is actually very cleverly modified according to current environmental needs. Even before a baby is born, it already knows what world to prepare itself for. Moshe in this talk sheds light on his groundbreaking findings. Moshe Szyf is one of the poineers in the field of epigenetics. Szyf’ lab has proposed three decades ago that DNA methylation is a prime therapeutic target in cancer and other diseases and has postulated and provided the first set of evidence that the “social environment” early in life can alter DNA methylation launching the emerging field of “social epigenetics”. The Szyf’ lab is interested in understanding basic epigenetic mechanisms and their broad implications in human behavior, health and disease as well as in developing epigenetics’ based therapeutics and diagnostics. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx 194 Comments rongmaw lin Add a comment... M Frusciante M Frusciante 2 years ago You know the other day I was thinking, how do instincts work? How does an organism have knowledge already programmed in? I thought, it must be coded into it's genes. Then I began the searching, days later here I am. I must say epigenetics is truly one of these most fascinating areas of science I've ever come across, I can't wait to learn more 89 M Frusciante M Frusciante 2 years ago Amazing. One of the best Ted talks I've seen. One question though, what are these drugs they used to increase/decrease methylation? Or, can this be done by the individual through other means? Absolutely fascinating stuff, I'm extremely interested. 26 Tariq Zaman Tariq Zaman 1 year ago This is really a great talk on epigenetics. For 2 decades I investigated function of many different genes by deleting and inserting into genome. Learned something new that will help shape new strategies like looking at genes expression profile in Autism spectrum disorder. 15 Kawing Chung Kawing Chung 5 days ago Very interesting! But I don't understand how the "decrease DNA methylation" drugs can act on the target genes specifically without altering other gene expressions 1 Obilaja Fisayo Obilaja Fisayo 6 months ago I have watched a lot of ted talks over the years, and I can say that this is by far one of the best and well composed tedTalk that I have ever seen. Aside being a great talk, this is an incredible piece of science. 3 annastayziaa annastayziaa 2 years ago THIS MAKES ME SO HAPPY AND GIVES ME SO MUCH HOPE FOR HUMANITY YAAAAY EPIGENETICS ROCK❣️❣️❣️ 53 Nisha Alex Nisha Alex 2 years ago Wow! So much potential to make the society and the environment better. I am hopeful 3 Brian Allen Brian Allen 1 year ago Great research, gives hope to those with diseases like cancer, how can we change our cells to turn back to healthy cells 2 curestruck curestruck 3 years ago I love Ted as much as the next guy but jeez this has created such a spark within me, really profound in (hopefully an obvious way of) the importance of cultivating love 14 pk eggle pk eggle 2 years ago Wow. This says a lot about the value of stay-at-home mothers! a Institutionalized day-care & returning to work after a few wks/months a failed idea-- rather than several years later like mothers used to do. But this was before housing costs out paced what working young fathers could afford or support. This could even be a call for a return to affordable housing, by reforming how banks use compound-interest that often pushes out the 1st-time home buyer, by doubling or tripping the actual cost of a financed home. It's a thought. 10 N. Mc N. Mc 2 years ago This is a very vital piece of Science. 41 JustKeith JustKeith 5 years ago I thought he was missing part of his head at first. This sounds promising. I need this stuff. 179 Pure Healing Pure Healing 1 year ago Incredible. The adoption have an impact in the individual as well indeed confirm the experiment... epigenetic is incredible. 1 Jam Hopsey Jam Hopsey 1 year ago this hits hard. I got a girlfriend who has been mistreated her entire life and she has such a difficult time expecting anything else from the world except the worst and its probably because she's been programmed that way 7 Franklin Ayala Franklin Ayala 2 years ago Here lyes the key to a healthy beautiful life and yet we fail to acknowledge it. We need singularity in this world as we are all interconnected one way or another. The world needs us and the dots are lined up just look at what we are watching. 17 Dawn Brosnan Dawn Brosnan 3 years ago Fabulous talk. Thank you. :) 3 Daffodils Daffodils 11 months ago Wonderful performance 👏 Gebarowski Brikanovic Gebarowski Brikanovic 2 years ago "If we can program genes, can we deprogram them" OMG!!! 36 Logan Dowell Logan Dowell 5 years ago this is why attachment parenting produces the best outcomes. 50 Mike Taiwan Walk city Mike Taiwan Walk city 1 year ago Very interesting, open eyes, open minds. Modify DNA with care and Love. Experience on the monkeys Lily Bishop Lily Bishop 10 months ago Literally just changed my entire life plan to study this when I go to University 1 Mauro Torales Mauro Torales 5 months ago Muy determinista, la interpretación que hace de los efectos de los mecanismos epigenéticos. Sus interpretaciones sobre los resultados de los experimentos demuestran una mirada aporofóbica y clasista. Su discurso plagado de causalidades (relaciones lineales y necesarias entre causas y efectos), denotan una fuerte mirada reduccionista. Hacer extrapolaciones lineales de resultados de experimentos en laboratorios, a sociedades humanas es una práctica biopolítica muy peligrosa. Los mecanismos epigenéticos y sus formas de herencia, son una cosa. La aporofobia, es otra Thanya Battaglia Thanya Battaglia 1 year ago Excellent speach! Kamkam Kozkoz Kamkam Kozkoz 2 years ago If only he could elaborate twice as much with each paragraphs , give us some facts 1 AnaCheque AnaCheque 3 years ago 04.27.19 SYNCHRONICITY!! Some time ago, perhaps years ago, my son wrote the word, "Bratislava" on my note pad next to my computer keyboard, that I have been seeing all month while doing my financials. However here is the Synchronicity...for whatever reason or meaning...I am watching a video and it is titled, 'TEDxBratislava 13 zencat999 zencat999 2 weeks ago (edited) great opening line...."it all came to light in a dark bar in madrid". lol....classic! Ron Harns Ron Harns 3 years ago This makes a good case for longer paid famiy leave. Society would benefit as a whole, 87 Mark Caseon Mark Caseon 3 years ago "Even before a baby is born, it already knows what world to prepare itself for." - What if baby is a born in a very hostile and aggressive enviroment? 25 HomeSweet RV HomeSweet RV 2 years ago Fascinating! Brancaalice Brancaalice 2 years ago We inherited social behavior from animals, ours ancestors learned social behavior be good to protect their life. There many eyes to look for predators around, more choice to survive. That we are until now. Heart beat together in any creature. Yes Yes 1 year ago But science needs to stop experimenting on animals for real damn that's torture 4 Anoop Parmar Anoop Parmar 2 years ago Now parents need to change everything for their childrens goodness 5 Science Science 2 years ago One of the best thing on internet. 19 zelen plav zelen plav 2 years ago (edited) Babies orphaned in Europe, raised by overworked caretakers that did not have anyone holding and cuddling them grew up totally cold, unresponsive and lacking in normal compassion and no empathy. 9 nicolas koltsidas nicolas koltsidas 2 years ago with which method the maps of dna methylation are produced? 5 navdeep singh Sowanni navdeep singh Sowanni 2 years ago The vast ocean lies unexplored . We are just playing with the pebbles washed on the seashore 7 dakota cook dakota cook 3 years ago I looked at my phone randomly and i thought he didn't have half his head. I was very happy for him when i realized it was just a hat. What's the proper name for that hat? 7 Aina Sakeenah Aina Sakeenah 1 year ago Really really interesting! Sea Foam Sea Foam 11 months ago This epigentic science would then seem to support attachment style parenting. Aka leaving the child to “cry it out” on their own in the crib is not a good idea 2 Christine Harkleroad Christine Harkleroad 2 years ago Fascinating 👍 3 Lily Bishop Lily Bishop 10 months ago Literally just changed my entire life plan to study this when I go to University 1 Mauro Torales Mauro Torales 5 months ago Muy determinista, la interpretación que hace de los efectos de los mecanismos epigenéticos. Sus interpretaciones sobre los resultados de los experimentos demuestran una mirada aporofóbica y clasista. Su discurso plagado de causalidades (relaciones lineales y necesarias entre causas y efectos), denotan una fuerte mirada reduccionista. Hacer extrapolaciones lineales de resultados de experimentos en laboratorios, a sociedades humanas es una práctica biopolítica muy peligrosa. Los mecanismos epigenéticos y sus formas de herencia, son una cosa. La aporofobia, es otra Thanya Battaglia Thanya Battaglia 1 year ago Excellent speach! Kamkam Kozkoz Kamkam Kozkoz 2 years ago If only he could elaborate twice as much with each paragraphs , give us some facts 1 AnaCheque AnaCheque 3 years ago 04.27.19 SYNCHRONICITY!! Some time ago, perhaps years ago, my son wrote the word, "Bratislava" on my note pad next to my computer keyboard, that I have been seeing all month while doing my financials. However here is the Synchronicity...for whatever reason or meaning...I am watching a video and it is titled, 'TEDxBratislava 13 zencat999 zencat999 2 weeks ago (edited) great opening line...."it all came to light in a dark bar in madrid". lol....classic! Ron Harns Ron Harns 3 years ago This makes a good case for longer paid famiy leave. Society would benefit as a whole, 87 Mark Caseon Mark Caseon 3 years ago "Even before a baby is born, it already knows what world to prepare itself for." - What if baby is a born in a very hostile and aggressive enviroment? 25 HomeSweet RV HomeSweet RV 2 years ago Fascinating! Brancaalice Brancaalice 2 years ago We inherited social behavior from animals, ours ancestors learned social behavior be good to protect their life. There many eyes to look for predators around, more choice to survive. That we are until now. Heart beat together in any creature. Yes Yes 1 year ago But science needs to stop experimenting on animals for real damn that's torture 4 Anoop Parmar Anoop Parmar 2 years ago Now parents need to change everything for their childrens goodness 5 Science Science 2 years ago One of the best thing on internet. 19 zelen plav zelen plav 2 years ago (edited) Babies orphaned in Europe, raised by overworked caretakers that did not have anyone holding and cuddling them grew up totally cold, unresponsive and lacking in normal compassion and no empathy. 9 nicolas koltsidas nicolas koltsidas 2 years ago with which method the maps of dna methylation are produced? 5 navdeep singh Sowanni navdeep singh Sowanni 2 years ago The vast ocean lies unexplored . We are just playing with the pebbles washed on the seashore 7 dakota cook dakota cook 3 years ago I looked at my phone randomly and i thought he didn't have half his head. I was very happy for him when i realized it was just a hat. What's the proper name for that hat? 7 Aina Sakeenah Aina Sakeenah 1 year ago Really really interesting! Sea Foam Sea Foam 11 months ago This epigentic science would then seem to support attachment style parenting. Aka leaving the child to “cry it out” on their own in the crib is not a good idea 2 Christine Harkleroad Christine Harkleroad 2 years ago Fascinating 👍 3 hyperreality hyperreality 1 year ago (edited) The destiny of DNA includes the epigenome and all the possible ways it can change DNA and subsequently gene expression so the title doesn't really make sense, DNA is still ultimately in control of the car because without DNA you have no epigenome and so the epigenome must be subservient to DNA. Bashair AlHidri Bashair AlHidri 1 year ago Interesting, thank you. Hanoi Pro Hanoi Pro 2 years ago pretty sure very few geneticists are gonna tell you "poor people are poor because their genes made them poor" 7:06 3 The Proof is in the Plants - and fungi The Proof is in the Plants - and fungi 1 year ago 👏👏👏 AlanUy212 AlanUy212 3 years ago Excellent 2 venture venture 2 years ago Should be more well known 7 Mailing Myself Mailing Myself 11 months ago now I want to know that how this epigenetics can help in curing cancer. Kasparov The God of War Kasparov The God of War 1 year ago (edited) My mom tried to convince me of epigenetics dor the past 20 years. I'm still not convinced ane ane 3 years ago WOW!!!!! 2 Johny Relax Johny Relax 3 years ago Damn this is too interesting! 8 Lilmisshotrod1 Lilmisshotrod1 6 days ago Is THIS, what Our Creator Wants Us To Do?🤔⬆️🕊️♾️💝🤙🎶😃🪶 Kelley Strobel Kelley Strobel 1 year ago It’s always the mother): but I accept that. 2 Bobcat Young Bobcat Young 1 year ago Too short ! I need more zelen plav zelen plav 2 years ago (edited) During pregnancy if a women is stressed, depressed, abused and malnutrished, her child will exhibit in physical, emotional, mental and problems. 4 bigrichard97 bigrichard97 2 years ago I wonder how you get methylation drugs. I need them. creativecompanion creativecompanion 3 weeks ago If a person is severely disabled from birth could they change it? I really want to change my dna to be a normal person. Dr S Ranjan MBBS Acupuncturist Dr S Ranjan MBBS Acupuncturist 2 years ago 11:08 Stress increase diseases. 8 Jyoti Dubey Jyoti Dubey 1 year ago 🙌🏻🙌🏻🙌🏻🙌🏻❤ Chris Y. Chris Y. 4 years ago When I watched this there was translation script in korean, but here isn't. 2 Catherine Greenup Catherine Greenup 2 years ago OK I was loved dearly all throughout childhood, by my parents and my grandparents. In fact my leacher said I had too many mothers. Being an only child you’d expect to say, Oh she was spoiled rotten. No, I wasn’t in fact. My family weren’t cuddlers. They weren’t rich, they were hard working. It was instilled in me from being young you must work hard for a living. You must look after your own affairs. You must do the right thing, responsibility is extremely important and comes before all else. It was a strict up bringing, carefully cared for and yes I knew I was special and loved. But I was also very lonely, even isolated, shy and often quite ill whilst growing up. Without knowing it I was under a lot of pressure to conform. Do what I was told. As were my parents to provide. My responsibility was to be a respectful child and never go against what my family believed. 3 hyperreality hyperreality 1 year ago (edited) The destiny of DNA includes the epigenome and all the possible ways it can change DNA and subsequently gene expression so the title doesn't really make sense, DNA is still ultimately in control of the car because without DNA you have no epigenome and so the epigenome must be subservient to DNA. Bashair AlHidri Bashair AlHidri 1 year ago Interesting, thank you. Hanoi Pro Hanoi Pro 2 years ago pretty sure very few geneticists are gonna tell you "poor people are poor because their genes made them poor" 7:06 3 The Proof is in the Plants - and fungi The Proof is in the Plants - and fungi 1 year ago 👏👏👏 AlanUy212 AlanUy212 3 years ago Excellent 2 venture venture 2 years ago Should be more well known 7 Mailing Myself Mailing Myself 11 months ago now I want to know that how this epigenetics can help in curing cancer. Kasparov The God of War Kasparov The God of War 1 year ago (edited) My mom tried to convince me of epigenetics dor the past 20 years. I'm still not convinced ane ane 3 years ago WOW!!!!! 2 Johny Relax Johny Relax 3 years ago Damn this is too interesting! 8 Lilmisshotrod1 Lilmisshotrod1 6 days ago Is THIS, what Our Creator Wants Us To Do?🤔⬆️🕊️♾️💝🤙🎶😃🪶 Kelley Strobel Kelley Strobel 1 year ago It’s always the mother): but I accept that. 2 Bobcat Young Bobcat Young 1 year ago Too short ! I need more zelen plav zelen plav 2 years ago (edited) During pregnancy if a women is stressed, depressed, abused and malnutrished, her child will exhibit in physical, emotional, mental and problems. 4 bigrichard97 bigrichard97 2 years ago I wonder how you get methylation drugs. I need them. creativecompanion creativecompanion 3 weeks ago If a person is severely disabled from birth could they change it? I really want to change my dna to be a normal person. Dr S Ranjan MBBS Acupuncturist Dr S Ranjan MBBS Acupuncturist 2 years ago 11:08 Stress increase diseases. 8 Jyoti Dubey Jyoti Dubey 1 year ago 🙌🏻🙌🏻🙌🏻🙌🏻❤ Chris Y. Chris Y. 4 years ago When I watched this there was translation script in korean, but here isn't. 2 Catherine Greenup Catherine Greenup 2 years ago OK I was loved dearly all throughout childhood, by my parents and my grandparents. In fact my leacher said I had too many mothers. Being an only child you’d expect to say, Oh she was spoiled rotten. No, I wasn’t in fact. My family weren’t cuddlers. They weren’t rich, they were hard working. It was instilled in me from being young you must work hard for a living. You must look after your own affairs. You must do the right thing, responsibility is extremely important and comes before all else. It was a strict up bringing, carefully cared for and yes I knew I was special and loved. But I was also very lonely, even isolated, shy and often quite ill whilst growing up. Without knowing it I was under a lot of pressure to conform. Do what I was told. As were my parents to provide. My responsibility was to be a respectful child and never go against what my family believed. 3 Vashti Camille Jaggernauth Vashti Camille Jaggernauth 1 year ago 👏👏👏👏👏👏 A G A G 3 months ago Ignore the woke new age BS of no meats no dairy. Follow the Eastern cultures. Lard, ghee, kefir, fish - all have extremely important microbiome positive ingredients. Charlie Wendy Charlie Wendy 1 year ago I want the drug they gave to those rats xD BKYBZ BKYBZ 4 years ago The Bible said our behavior goes back 7 generations based on our parents lives. same thing. 21 C S C S 2 years ago awesome AWESOME awesome . . . 3 C Mauro C Mauro 2 years ago it seems the Ecuadorians did not appreciate their photo being taken. 2 venture venture 2 years ago Needs way more views. Only 75 comments? I don't want to live on this planet anymore. XD 10 Laurel Kardison Laurel Kardison 1 year ago All the dislikes are people who had horrible mothers 2 Lorena Barcena Lorena Barcena 4 years ago Is it possible to change your DNA to make you run faster? 1 Matthew Macey Matthew Macey 2 years ago Someone should ask him his opinion on eugenics. He seems to be walking down the same path, ironic. 2 sanaz bani sanaz bani 4 years ago Is this related to psychology? 1 GGR TheMostGodless GGR TheMostGodless 2 years ago (edited) A "scientist" believer in god, as of course he has to demonstrate with wearing that thing on his head... I thought scientist demand proof before having "faith" which once you have proof you don't NEED to have faith. Still, I wish most doctors had half the knowledge this man has. Most doctors are stopped learning even before they graduated, ask most of them what books or "further learning" courses they have taken that they don't have to take, and the answer is ZEROOOOOO. No books at all, and no other learning, except overcharging patients and deal making with pharmaceuticals. They are recipe giving men. Kyle Johnson Kyle Johnson 3 years ago maybe there is something here tied to the trend in fatherless homes in america on the rise following the introduction of welfare... and the decline of healthy masculinity in america :/ 8 Вячеслав Леонов Вячеслав Леонов 3 years ago Я думал , что только в России есть такие..........."умные". Диз Martian Martian 5 years ago 1st 5 yourtv yourtv 3 years ago What is with the what? yourtv yourtv 3 years ago Please tell me if there is God or not? 2 Eric Phalen Eric Phalen 2 years ago Nurture 4 Michael Harris Michael Harris 3 years ago (edited) This is BS, give a child more attention and it'll achieve greater things or become spoilt brats. Give them little attention and they may achieve little or be the best most creative person on the planet. So this is BS, telling us nothing except now it's scientific so they can claim to have found out what you all ready knew. 3 Simply Human Simply Human 4 years ago (edited) Methylation cycle and its effect on epigenetics' and brain health was pioneered by William Walsh, not this Jew who is seemingly taking credit for other peoples ideas. 8 Vashti Camille Jaggernauth Vashti Camille Jaggernauth 1 year ago 👏👏👏👏👏👏 A G A G 3 months ago Ignore the woke new age BS of no meats no dairy. Follow the Eastern cultures. Lard, ghee, kefir, fish - all have extremely important microbiome positive ingredients. Charlie Wendy Charlie Wendy 1 year ago I want the drug they gave to those rats xD BKYBZ BKYBZ 4 years ago The Bible said our behavior goes back 7 generations based on our parents lives. same thing. 21 C S C S 2 years ago awesome AWESOME awesome . . . 3 C Mauro C Mauro 2 years ago it seems the Ecuadorians did not appreciate their photo being taken. 2 venture venture 2 years ago Needs way more views. Only 75 comments? I don't want to live on this planet anymore. XD 10 Laurel Kardison Laurel Kardison 1 year ago All the dislikes are people who had horrible mothers 2 Lorena Barcena Lorena Barcena 4 years ago Is it possible to change your DNA to make you run faster? 1 Matthew Macey Matthew Macey 2 years ago Someone should ask him his opinion on eugenics. He seems to be walking down the same path, ironic. 2 sanaz bani sanaz bani 4 years ago Is this related to psychology? 1 GGR TheMostGodless GGR TheMostGodless 2 years ago (edited) A "scientist" believer in god, as of course he has to demonstrate with wearing that thing on his head... I thought scientist demand proof before having "faith" which once you have proof you don't NEED to have faith. Still, I wish most doctors had half the knowledge this man has. Most doctors are stopped learning even before they graduated, ask most of them what books or "further learning" courses they have taken that they don't have to take, and the answer is ZEROOOOOO. No books at all, and no other learning, except overcharging patients and deal making with pharmaceuticals. They are recipe giving men. Kyle Johnson Kyle Johnson 3 years ago maybe there is something here tied to the trend in fatherless homes in america on the rise following the introduction of welfare... and the decline of healthy masculinity in america :/ 8 Вячеслав Леонов Вячеслав Леонов 3 years ago Я думал , что только в России есть такие..........."умные". Диз Martian Martian 5 years ago 1st 5 yourtv yourtv 3 years ago What is with the what? yourtv yourtv 3 years ago Please tell me if there is God or not? 1:32 / 18:40 Epigenetics and the influence of our genes | Courtney Griffins | TEDxOU 809,031 viewsFeb 23, 2012 9.7K DISLIKE SHARE DOWNLOAD CLIP SAVE TEDx Talks 35.1M subscribers This talk was given at a local TEDx event, produced independently of the TED conferences. Because we want to understand what genes are required for blood vessel development, Courtney Griffin studies certain enzymes that help turn genes on and off. These enzymes are specifically involved in relaxing DNA that is normally tightly coiled up in our cells. 341 Comments rongmaw lin Add a comment... Mark Twain Mark Twain 3 years ago This is the most extraordinary discovery since DNA itself (c.1953). It explains so much that we did not realize about human functioning and dysfunction. This lady is a wonderful teacher. 19 Maria Richter Maria Richter 5 years ago Thank you, I now understand epigenetics better than reading my book for my class . Very well explained. 74 Sherrie Vitello Sherrie Vitello 6 years ago Epigenetics. Your genes are not set in stone. You don't have to live with the fact that just because your parents or grandparents were unhealthy doesn't mean you have no other choice but to be unhealthy also. You can change particular genes in your body just by eating the right foods and getting rid of the toxic bad habits, of any kind, and reprogramming your cells to make your body much healthier and stronger. By also applying an exercise routine that will decrease stress is also key to fixing your genes. Epigenetics is a new science that is telling us that we can take control of our bodies destiny and make it so healthy that our longevity will stamp out diseases and we can live a happier, healthier, more rewarding long life. If you have never heard about epigenetics, you really should get your knowledge on about these wonderfully new ground breaking science. The facts are clear and we truly do have control over how our lives are lived. 262 David Brewer David Brewer 2 years ago Very interesting indeed. I was actually looking for a new hobby so now I might take up DIY genetic manipulation on myself! 113 akrcda akrcda 11 months ago Excellent speaker who made the concepts quite accessible. I’m very interested to learn more about this emerging field while also inspired to go back and learn the fundamentals of DNA, genetics and organic chemistry to better understand the topic. 4 Vinnie Babauta Vinnie Babauta 7 years ago This is AMAZING!! GREAT INFORMATION! what blew my mind was 50 trillion cells in a human body, each cell having a strand of 6 feet of DNA in each cell, and each of DNA are fit into this 400000 times small than a cell in a nucleus cell! WOW!! that is what blew my mind! I'm happy to learn this! 109 Michael Wilkins Michael Wilkins 5 years ago This is great information that people need to know regarding the healthy birth of children. We can influence the outcome of a birth by changing our habits before conceiving.Great evidence for a plant based lifestyle. 10 Jondi Whitis Jondi Whitis 5 years ago I liked this. My favorite for accessibility on the same subject is Dr Bruce Lipton's book, The Biology of Belief. I believe this whole field will explode our possibilities and the way we think about our environment, physical, emotional, mental. Epigenetics goes a long way towards explaining how Energy Psychology and EFT work so well, documented in the 60+ peer-reviewed published studies. Challenging our convictions is what science is supposed to be all about, and I'm delighted with Courtney Griffins' presentation that paves the way for a better understanding of who we are and how we're impacted, and what we can do with that information. 13 Bob van Heukelom Bob van Heukelom 4 years ago This is a very helpful and clarifying TED talk about epigenetics. I really admire the way you teaches us.Thank you! 22 Mister Random Mister Random 7 years ago such a great way to present fairly complex concepts, loved the way she did the pauses between sentences, words, and also how the powerpoint was short and spot on on the stuff that is greatly helped by images. Not to say about the subject, GREAT talk 22 guillermo dehollander guillermo dehollander 3 years ago Absolutely beautifully presented and explained. I actually think I understood most of what Courtney said. Beautifully composed sentences, very pleasant voice. No extraneous words. I loved it! 💐🌿🌹🌿💐 3 Vitthal Sawant Vitthal Sawant 3 years ago Great information. To change our bad habits we need to control our mind by performing regular exercises, pranayam, yoga and Meditation which can transform our body cells and thoughts 6 Comande sua Vida! Comande sua Vida! 3 years ago Muito bom!! Grata por compartilhar seu conhecimento 3 Scarlett Rose Scarlett Rose 1 year ago Incredible TED talk! You've really done a great job explaining this clearly corbus aurelius corbus aurelius 6 years ago Great talk! Thank u for posting and for Dr. Griffin, for making it such an easy entry into understanding a little about this pretty amazing topic. 3 Her Melanin Her Melanin 4 years ago Awesome presentation. touched on some very important aspects. Learnt a lot. Thank you! 4 Teksunai Teksunai 9 years ago Thank you for posting this, individual! I have an interest in epigenetics, and having a link to further my knowledge in it is greatly appreciated! =) 7 Debbie Debbie 8 months ago (edited) Excellent! I believe its all true as i have asthma and i started a raw plant based diet and it is already helping my asthma. My plan is to stick with it and journal my findings. It has also cut down my meds 40 percent so far. I understand asthma is a chronic disease but i also believe there is a lot you can do to manage it and help yourself. Most of all i dont miss the sweets, processed foods or junk food❤ 1 Rick Monsour Rick Monsour 8 years ago I am not a geneticist but Dr Courtney makes a great case that demonstrate the effects of lifestyle and personal choices and the outcome of how well we live. It makes sense that our choices will affect our genetic destiny either + or -. There have been lots of examples of genetically identical twins who have made different life style choices and the affects on how they age. This also has been recorded with gene chip analysis which is state of the art technology in measuring objectively how our genes our affected by lifestyle choices. So I don't think what she is saying is mere speculation. 2 Kim Mobey Kim Mobey 3 years ago Exquisitely explained! Thank you for this! 2 Antonio Marin Antonio Marin 2 years ago This is one of the most amazing lectures of Epigenetics. Ummm, now I can understand that is now everything is lost. Means if our parents had bad habits, as not eating healthy and another things against our bodies, we can change and be healthy... 2 Joaquin Misa Jr. Joaquin Misa Jr. 2 years ago Very informative, well articulated,.... and with a touch of humor, too. Kudos! 1 Robin Hood 07 Robin Hood 07 3 months ago Great speech, Mrs. Griffin. I loved it and I learnt so much. Thank you! GuardianofTruth146 GuardianofTruth146 5 months ago Great talk and now I have another passion to study epigenetics! Thank you 😊💓 1 STREET TALK 4 THE SOUL STREET TALK 4 THE SOUL 4 years ago thank you for putting this in such a way that us "regular" people could easily follow. very much appreciated! 1 Mansu Mansu 1 year ago Best 19 minutes i have spent on my life, hopefully modern medicine can produce such medications based on these theories plus the importance of life style and diet among people so raising awareness is also playing part to fight or prevention of cancer 🙏🙏🙏 Suny Mad Suny Mad 6 years ago Extremely well explained! 3 Биохакер PRO || Дмитрий Соколов Биохакер PRO || Дмитрий Соколов 1 year ago Thank you and Courtney Griffin for the wonderful video! One question (and I must apologize in advance - I am in no way any expert in the area, just have read this and that): it is mentioned in the video at 7:20, that there are "not so many" epigenetic marks on the genome in the beginning, and that they begin to appear later in development, as the cells start to divide and receive signals from outside. However, what I have read elsewhere, says the oppozite: the zygote - as the ultimate "stem cell" - has most of its genome silenced and genes non-transcribed. And it is early in the blastocyst stage that some of these epigenetic marks (particularly methylgroups) are removed from DNA and acetylgroups added to histones, thus beginning to "lead" the cell towards a certain genetic/developmental trail. I have read, that in mice silent genomen becomes not-fully-silent around mid-1-cell stage, although more transcription begins at 2-cell stage. Not sure if it is different in humans. Will appreciate the explanation. Sadikshya Nepal Sadikshya Nepal 2 years ago this is probably the most informative ted talk for me that i've ever come across. greatly told 1 adam jenkins adam jenkins 7 years ago The interaction of our genes with our immediate environment (whatever the stage of development) shouldn't be that much of a shock, people. It's good that they can measure this process at a microscopic level, though. And an interesting subject , nonetheless! 5 w\o Illusion w\o Illusion 4 years ago A remarkable good presentation about the backround of epigenetics! Great thanks for sharing. 1 DavidL999 DavidL999 9 years ago Good video, very well explained, thanks! 1 Noshin Tabassum Noshin Tabassum 2 years ago Thank you so much for this! This truly is profound for me! Matheo Galatis Matheo Galatis 5 years ago I love this topic! We are not doomed by our genetic heritage. They provide the perfect conditions for us to grow and live our greatest potential. Additional to the creation of medicines that can support gene heritage are a number of psychotherapeutic methods that can heal genetic expressions inherited from our ancestors. 4 Renukadevi Garla Renukadevi Garla 1 year ago Amazing talk! Well explained! Daniel Phahla Daniel Phahla 7 months ago Very fruitful presentation, and let's remember that healthy people produce healthy offsprings, as we continue to make food our medicine and medicine our food, because prevention is better than cure. 1 macmarty2025 macmarty2025 9 years ago Very informative and interesting talk. Thank you. 1 Jervns Jervns 7 years ago Great presentation, I was on board until around 15:01 - Teacher's we should be following should be teaching us how to properly prepare the foods we eat and that the life style choices we make (the types of thoughts we think) will determine our physical experience. I have no problem with her description of how gene's express themselves, It just seems intuitive to me, that our science - as good as it is, is still learning to crawl - and this is Huge. 8 Nishant Singh Nishant Singh 3 years ago Such a brilliant talk! Thanks. 2 shirley A-z shirley A-z 5 years ago (edited) The thing is no identical twins have identical environments, and there is no way to know how the smallest of differences could or could not impact on personality. This is the inherent flaw in all twin studies, the assumption that twins raised together can be treated as though they have been raised in an identical environment. Her pie chart would have made more sense if it were presented as a venn diagram with epigenetics the area where nature and nurture overlap rather than being separate from nature and nurture. 20 Antonio Marin Antonio Marin 2 years ago This is one of the most amazing lectures of Epigenetics. Ummm, now I can understand that is now everything is lost. Means if our parents had bad habits, as not eating healthy and another things against our bodies, we can change and be healthy... 2 Joaquin Misa Jr. Joaquin Misa Jr. 2 years ago Very informative, well articulated,.... and with a touch of humor, too. Kudos! 1 Robin Hood 07 Robin Hood 07 3 months ago Great speech, Mrs. Griffin. I loved it and I learnt so much. Thank you! GuardianofTruth146 GuardianofTruth146 5 months ago Great talk and now I have another passion to study epigenetics! Thank you 😊💓 1 STREET TALK 4 THE SOUL STREET TALK 4 THE SOUL 4 years ago thank you for putting this in such a way that us "regular" people could easily follow. very much appreciated! 1 Mansu Mansu 1 year ago Best 19 minutes i have spent on my life, hopefully modern medicine can produce such medications based on these theories plus the importance of life style and diet among people so raising awareness is also playing part to fight or prevention of cancer 🙏🙏🙏 Suny Mad Suny Mad 6 years ago Extremely well explained! 3 Биохакер PRO || Дмитрий Соколов Биохакер PRO || Дмитрий Соколов 1 year ago Thank you and Courtney Griffin for the wonderful video! One question (and I must apologize in advance - I am in no way any expert in the area, just have read this and that): it is mentioned in the video at 7:20, that there are "not so many" epigenetic marks on the genome in the beginning, and that they begin to appear later in development, as the cells start to divide and receive signals from outside. However, what I have read elsewhere, says the oppozite: the zygote - as the ultimate "stem cell" - has most of its genome silenced and genes non-transcribed. And it is early in the blastocyst stage that some of these epigenetic marks (particularly methylgroups) are removed from DNA and acetylgroups added to histones, thus beginning to "lead" the cell towards a certain genetic/developmental trail. I have read, that in mice silent genomen becomes not-fully-silent around mid-1-cell stage, although more transcription begins at 2-cell stage. Not sure if it is different in humans. Will appreciate the explanation. Sadikshya Nepal Sadikshya Nepal 2 years ago this is probably the most informative ted talk for me that i've ever come across. greatly told 1 adam jenkins adam jenkins 7 years ago The interaction of our genes with our immediate environment (whatever the stage of development) shouldn't be that much of a shock, people. It's good that they can measure this process at a microscopic level, though. And an interesting subject , nonetheless! 5 w\o Illusion w\o Illusion 4 years ago A remarkable good presentation about the backround of epigenetics! Great thanks for sharing. 1 DavidL999 DavidL999 9 years ago Good video, very well explained, thanks! 1 Noshin Tabassum Noshin Tabassum 2 years ago Thank you so much for this! This truly is profound for me! Matheo Galatis Matheo Galatis 5 years ago I love this topic! We are not doomed by our genetic heritage. They provide the perfect conditions for us to grow and live our greatest potential. Additional to the creation of medicines that can support gene heritage are a number of psychotherapeutic methods that can heal genetic expressions inherited from our ancestors. 4 Renukadevi Garla Renukadevi Garla 1 year ago Amazing talk! Well explained! Daniel Phahla Daniel Phahla 7 months ago Very fruitful presentation, and let's remember that healthy people produce healthy offsprings, as we continue to make food our medicine and medicine our food, because prevention is better than cure. 1 macmarty2025 macmarty2025 9 years ago Very informative and interesting talk. Thank you. 1 Jervns Jervns 7 years ago Great presentation, I was on board until around 15:01 - Teacher's we should be following should be teaching us how to properly prepare the foods we eat and that the life style choices we make (the types of thoughts we think) will determine our physical experience. I have no problem with her description of how gene's express themselves, It just seems intuitive to me, that our science - as good as it is, is still learning to crawl - and this is Huge. 8 Nishant Singh Nishant Singh 3 years ago Such a brilliant talk! Thanks. 2 shirley A-z shirley A-z 5 years ago (edited) The thing is no identical twins have identical environments, and there is no way to know how the smallest of differences could or could not impact on personality. This is the inherent flaw in all twin studies, the assumption that twins raised together can be treated as though they have been raised in an identical environment. Her pie chart would have made more sense if it were presented as a venn diagram with epigenetics the area where nature and nurture overlap rather than being separate from nature and nurture. 20 metaDot metaDot 9 years ago Even common sense needs to be proven, that is the point of science, it doesn't take things at face value, it tries to explain the intricate processes that are involved. 1 R. Müller R. Müller 5 months ago Just 6 minutes in and she explained more than my college professor ever did in a 50 min class... dang 1 Rising Sun Rising Sun 7 years ago Would like to see experiments on the effects of Ayahuasca to determine if there are any co-relations between its deprogramming affects from environmental conditioning and epigenetics. It is great to see scientist embracing this research in an attempt to create a pill however nature may already have provided us with the solution through the direct use of plant medicine such as Ayahuasca. 18 Regulation of Gene Expression: Operons, Epigenetics, and Transcription Factors 606,135 viewsOct 15, 2017 Professor Dave Explains 2M subscribers We learned about gene expression in biochemistry, which is comprised of transcription and translation, and referred to as the "central dogma" of molecular biology. But how is this process regulated? How does a cell know which genes to express and when? Well it's pretty complicated, but let's just get our feet wet by looking at operons, epigenetics, and transcription factors! Watch the whole Biology/Genetics playlist: http://bit.ly/ProfDaveBio General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych Microbiology/Infectious Diseases Tutorials: http://bit.ly/ProfDaveMicrobio Pharmacology Tutorials: http://bit.ly/ProfDavePharma History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs EMAIL► ProfessorDaveExplains@gmail.com PATREON► http://patreon.com/ProfessorDaveExplains Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience! Amazon: https://amzn.to/2HtNpVH Bookshop: https://bit.ly/39cKADM Barnes and Noble: https://bit.ly/3pUjmrn Book Depository: http://bit.ly/3aOVDlT 270 Comments rongmaw lin Add a comment... Yasmine Yasmine 6 months ago This is truly amazing how complex notions can become so easy to understand when clearly explained. I’m grateful for your channel. Lots of love from France. 60 J C J C 4 years ago There should be a YouTube university and all the best YouTube Professors should teach there. You Sir would be one of them. 616 Poonam Shah Poonam Shah 5 months ago Thanks alot Professor Dave. Your teaching videos are not just clearing the concepts but arousing the curiosity to learn more about the topics. 11 Jordian Morris Jordian Morris 2 months ago This was very short and precise. I understand clearly all that he said more than how my professor taught it. Thank you professor 🙏🏽 🤗 3 Dr. Cafer Ozdemir Dr. Cafer Ozdemir 3 years ago Great work as always Dave ! A small mistake: at 1:50 translation is happening in the wrong direction, it should start at 5’ 16 flyingbunniess flyingbunniess 3 years ago Professor Dave! I have been watching your videos for at least a year now. You got me an A- in Gen Chem 2, are currently helping me ace Organic Chem 1, and microbiology! THANK YOU. YOU ARE THE BEST <3 I only wish you were my actual microbio professor, then I wouldn't be so darn confused. 15 Professor Dave Explains Daniel Smith Daniel Smith 3 years ago Awesome video. Very clear and to the point. Ive been watching a lot of videos trying to wrap my head around this stuff -- this video made it stick. 8 Shreya Simhadri Shreya Simhadri 1 year ago YOU, prof Dave, are an AMAZING teacher. Thank you so much for your videos that I will be binging as a novice neuroscience major!!!! 3 Najdah Hidayah Najdah Hidayah 1 year ago thank you so much professor dave, you made it in a very simple explanation! 2 خليفة الحنطوبي خليفة الحنطوبي 3 years ago professor Dave you are a best teacher for chemistry and biology thanks for your efforts 5 VISHAL SOLANKI HTD (HYDRA TECH DISACTOR) GAMING VISHAL SOLANKI HTD (HYDRA TECH DISACTOR) GAMING 1 year ago Sir u are brilliant and fabulous explainer of concepts .Thanks a lot May God bless you and keep making such videos. 😚😚 1 O.N.C O.N.C 3 years ago i enjoy your lessons alot as they have been so so helpful..keep it up zerothehero123 zerothehero123 3 years ago Just found your channel and I absolutely love it! Very in depth videos for real science geeks! Subbed and liked! Arnold Katontoka Arnold Katontoka 1 year ago You're a great professor, your delivering techniques with clear expressional pictures makes it easier to understand things. But also suppose you're teaching someone who's being introduced to a topic the first time, you know, not to super summarize scientific concepts. 2 Madie Walter Madie Walter 3 years ago You just helped me survive my O. Chem final.... now I'm discovering you cover my Genetics final too. Just... wow. 34 Prabhpreet Prabhpreet 3 years ago Thanks and Plz give this professor a nobel prize for making this vedio ❤️ 1 ColoredBrothers ColoredBrothers 3 years ago (edited) I was interested in diet and people used to talk a lot about insulin metabolism at first, now I'm learning about genetics and gene expression because of research I did into the keto diet and its histone deacetylase inhibiting qualities, thank God for the internet and people like you Professor! I never really liked school but I do love learning with a passion. 6 NEHA MITHILESH NEHA MITHILESH 8 months ago Another wonderful session, thanks a ton BIO BROTHERS' LECTURES BIO BROTHERS' LECTURES 3 years ago A big fan of you sir !! Your video tutorials helped me a loot ❤ 1 Michelle Tarbox Michelle Tarbox 2 months ago Hi Professor Dave, one tiny thing I noticed in this video. When you say that methylation can make the DNA more accessible. It is the opposite, methylation makes the chromatin to coil tighter making the DNA less accessible. Thank you Vicky Imery Vicky Imery 1 year ago You’re an amazing teacher, thank You so much. 👌🏻🙏🏻🙌🏻 1 karim naraki karim naraki 2 years ago this explanation was so great thank u professor 3 Mariana Sayuri Udo Mariana Sayuri Udo 1 year ago Thank you very much for your brilliant explanation. The Top 10 The Top 10 2 years ago just loved it, such tough concepts explained cleanly ! bless professor Dave Demitri Welling Demitri Welling 4 months ago Excellent explanation, thanks again. 0:53 / 8:41 • Intro Epigenetics 261,462 viewsDec 18, 2020 5.6K DISLIKE SHARE DOWNLOAD THANKS CLIP SAVE Amoeba Sisters 1.37M subscribers You know all about how DNA bases can code for an organism's traits, but did you know there's more influencing phenotype than just the bases? Explore epigenetics with the Amoeba Sisters by learning about a few types of epigenetic marks and some examples of them in action. Contents: 00:00 Intro 2:14 Epigenetic Marks 4:13 Studies Involving Rodents & Epigenetics 5:51 Points about Inheritance and Factors Involving Inheritance 7:01 Why study Epigentics? 7:51 Epigentic Therapy ------------------------ REFERENCES: Clark, Mary Ann, Matthew Douglas, and Jung Choi. “16.3 Eukaryotic Epigenetic Gene Regulation- Biology 2e | OpenStax.” Biology 2e. OpenStax, March 28, 2018. https://openstax.org/books/biology-2e... Klug, William S, Michael R Cummings, Charlotte A Spencer, Michael Angelo Palladino, and Darrell Killian. Essentials of Genetics. Hoboken: Pearson, 2020. Adams, J. (2008) Obesity, epigenetics, and gene regulation. Nature Education 1(1):128 https://www.nature.com/scitable/topic... Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ. Epigenetic programming by maternal behavior. Nat Neurosci. 2004 Aug;7(8):847-54. doi: 10.1038/nn1276. Epub 2004 Jun 27. PMID: 15220929. https://pubmed.ncbi.nlm.nih.gov/15220... Robert A. Waterland, Randy L. Jirtle Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation Molecular and Cellular Biology Aug 2003, 23 (15) 5293-5300; DOI: 10.1128/MCB.23.15.5293-5300.2003 https://mcb.asm.org/content/23/15/5293 Dana C. Dolinoy, Dale Huang, Randy L. Jirtle Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development Proceedings of the National Academy of Sciences Aug 2007, 104 (32) 13056-13061; DOI: 10.1073/pnas.0703739104 https://www.pnas.org/content/104/32/1... Simmons, D. (2008) Epigenetic influence and disease. Nature Education 1(1):6 https://www.nature.com/scitable/topic... Zhang, T. Y., Labonté, B., Wen, X. L., Turecki, G., & Meaney, M. J. (2013). Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(1), 111–123. https://doi.org/10.1038/npp.2012.149 Oomen, M. E., & Dekker, J. (2017). Epigenetic characteristics of the mitotic chromosome in 1D and 3D. Critical reviews in biochemistry and molecular biology, 52(2), 185–204. https://doi.org/10.1080/10409238.2017... https://www.cdc.gov/genomics/disease/... https://www.sciencemag.org/news/1997/... ---------------------------- FURTHER READING SUGGESTIONS: This website is phenomenal for learning about epigenetics, and it was recommended in Pinky’s graduate course. https://learn.genetics.utah.edu/conte... More about histones? https://www.nature.com/scitable/defin... Why did we write the words “some exceptions” when mentioning that methyl groups *generally* prevent transcription? More info: https://www.ncbi.nlm.nih.gov/pmc/arti... We mention these are only some examples of epigenetic marks. What others exist? Check out this further reading which mentions Micro-RNAs. https://journals.physiology.org/doi/f... What do we mean about epigenetic tags being “cleared?” Two great further readings: https://learn.genetics.utah.edu/conte... https://science.sciencemag.org/conten... Epigenetic therapy with diseases? https://www.ncbi.nlm.nih.gov/pmc/arti... ---------------------------- Our Resources: Biology Playlist: https://www.youtube.com/playlist?list... GIFs: https://www.amoebasisters.com/gifs.html Handouts: https://www.amoebasisters.com/handout... Comics: https://www.amoebasisters.com/paramec... Unlectured Series: https://www.amoebasisters.com/unlectured Connect with us! Website: https://www.AmoebaSisters.com Twitter: https://www.twitter.com/AmoebaSisters Facebook: https://www.facebook.com/AmoebaSisters Tumblr: https://www.amoebasisters.tumblr.com Pinterest: https://www.pinterest.com/AmoebaSister­s Instagram: https://www.instagram.com/amoebasiste... Visit our Redbubble store at https://www.amoebasisters.com/store MUSIC: Intro music designed & performed by Jeremiah Cheshire. End music listed free to use/no attribution required from YouTube audio library. TRANSLATIONS: Turkish Subtitles by Kardelen Karaman We want to thank our amazing community for the generosity of their time in continuing to create translated subtitles. You can submit translated subtitles here: https://www.amoebasisters.com/pinkys-... Chapters Intro 0:00 Epigenetic Marks 2:14 Studies Involving Rodents & Epigenetics 4:13 Points about Inheritance and Factors Involving Inheritance 5:51 Why study Epigentics? 7:01 Epigentic Therapy 7:51