Mitochondria in Aging and Disease - David Sinclair 225,272 viewsMar 6, 2014

The Role of Mitochondria in Aging and Disease - David Sinclair 225,272 viewsMar 6, 2014 5.1K DISLIKE SHARE DOWNLOAD CLIP SAVE Serious Science 89K subscribers Source - http://serious-science.org/videos/738 Harvard Prof. David Sinclair on alphaproteobacteria, reactive oxygen species, and why the nucleus and the mitochondrial genomes are like a married couple 468 Comments rongmaw lin Add a comment... hamed shahbazi hamed shahbazi 6 years ago Amazing work Dr. Sinclair! So impressed with not only your work but your ability to explain it!! 20 Carroll Hoagland Carroll Hoagland 5 years ago (edited) Thanks Dr. Sinclair .. a fan ... will be watching the outcome of your research ... since I am specializing in mitochondrial dysfunction pertaining to aging from a dietary approach, since as you know we have longevity mechanisms that repair all damage ... we just have to get out of there way and support our own metabolic processes as these bodily mechanisms are far more powerful than any supplement you can take ..., 70 Going On 100 … the Centenarian Diet … maybe 70 Going On 128 … the Hayflick Limit, or if a fan of Ray Kurzweil … then this is all a Moot Point. 17 ido shapira ido shapira 3 years ago Great lecture, sounds like the progression of insulin resistance. Thank you 7 Biophilia Biophilia 11 months ago (edited) Sir I have read Your book "Lifespan" on the same topic of aging - It was too informative ..I am Your big fan 😇..Loads of love from India. 6 Ben Nguyen Ben Nguyen 3 years ago (edited) What determines the actual number of mitochondria per cell? Is it tissue dependent or based dynamically on energy needs? Bruce Hay on the HumanOS podcast, mentions with respect to mitochondrial genomes, you have hundreds to thousands of them: "In every cell we have hundreds to thousands of these organelles floating in the cytoplasm. They’re always being generated, and they have their own genomes. It’s not just one genome for all mitochondria, but thousands." Does he mean that each mitochondria only has a portion of the mtDna? Isn't the mtdna so small (37 genes) that it barely codes for proteins anyways (13)? He goes on to say, that the "nuclear DNA is well positioned for repair, because we have two copies of all of our chromosomes. What that means is, that if the copy you inherited from your father is damaged in some way, the copy you have from your mother can actually act as a template for repair. In that way, through homology based repair, you can oftentimes reconstruct the information that was lost in the damaged strand." There was a good 'Ask Me Anything - with Spencer Wells and Razib Khan', but didn't cover basic questions like this. 3 William Tomkiel William Tomkiel 2 years ago so glad I found this . . Been on NAD, 100 mg. /day for almost 2 1/2 years along with Co-Q10, Carnitine and Creatine as also being mitochondrial supporters and at 72 function and perform as a man many years younger but it's also about sleep , stress, recovery protocols for the gym work-outs and so forth. 8 Raven’s Lair Raven’s Lair 3 years ago Excellent. A very well spoken Professor. I have so many questions! Would taking NADH assist in this regeneration?? 4 Benjamin Hardisty Benjamin Hardisty 7 years ago I'm actually an aging researcher myself. Trust me, the Sinclair lab is top notch. SENS is funding great work, but they're not bringing anything to market in the next 10-20 years is my guess. I don't even think the NAD treatments or protein chaperone treatments Sinclair's lab is studying will get anywhere for years either. Consider that mTOR suppressors can both raise and lower lifespan and we don't fully understand why and we've been using them for decades to get an idea of the technical challenges. My mTOR model is a 26 ODE system. My lab mates said, "Oh that's why no one's made a good mTOR dynamics model." 22 Winston Chang Winston Chang 2 years ago Very insightful, Doctor Sinclair. I can clearly see the worth of you living a longer life because you are an important part of human society with your intelligence and knowledge. You are our mitochondria. But , what do I do with a longer life or that of billions of people. ? .....?....Like , I do not want mice to live longer lives..... 6 Rock Forester Rock Forester 10 days ago So exciting! One can try a lot of this right now, and very safely. My goal is to live heathfully for however long I do live, and this research is exactly the ticket. Glenn Decker Glenn Decker 6 years ago Great ideas, but more basic science questions should be asked at the level of cell biology and ultrastructure. 4 Command Results Command Results 7 years ago Great talk theorizing the future of mitochondrial development as related to aging and longevity, 2 Alex Alex 2 years ago (edited) Wouldn't it be possible to look at the mitochondrial bacteria types which are living outside of human bodies, where they are less protected, to find some gens which could be used to make our Mitochondria more resilient to damage and mutations? 4 Vicente Sanchez Vicente Sanchez 2 years ago Excellent lesson and info. Thx 1 Serious Science Neville J Neville J 3 years ago I am nearly 65 and have found that taking a small amount of D-Ribose and some Creatine daily has given me a massive amount of energy and strength so much so that two or three days a week, I will run a 5K followed by an hour in the gym doing a heavy workout and then do about 3/4 hour of swimming and still feel like I could do more. I suspect am as fit as I was in my twenties. 14 Hobby Farmer Hobby Farmer 4 months ago Dr. Sinclair looks younger now (2022) than he did in 2014. That means his approach worked, i.e. diet, intermittent fasting, supplements, etc. 5 ZeraYaqob ZeraYaqob 2 years ago The human microbiome directs the communication between the cells and mitochondria as well as between other cells. One example is the role of menaquinone or vitamin K2, synthesized from vitamin K1 or phytonadione by certain bacteria in our gut, as a participant of the oxidative phosphorylation or electron transport chain (where 94% of cellular energy is produced) through its ability to accept and transfer electrons. 16 Halima Zamouche Halima Zamouche 2 years ago All your work is amazing! Wish you all the best! You only need to get this you can live healthier and maximise your body's performances but you will certainly die! Thats sad but it's a fact that we can't deny! Everybody dies and it's for a reson if people that lived before us didn't die we would be looking for another planet to live in! Even cells in our bodies die when other new ones appear! God bless you! 1 Pritam Borah Pritam Borah 7 years ago your analogy of the broken marriage of genomes was the best part.... 64 Baljit Singh Baljit Singh 11 months ago Very informative information 👍🙏 2 Nick Foxer Nick Foxer 2 years ago (edited) Great video, but he failed to mention the most important molecule responsible for mitochondrial function. OXYGEN..... Two words: Ozone Therapy. Learn as much as you can about it. In my opinion it's the single greatest practice we have for restoring health. I actually think the "secret molecule" that he's hinting at toward the end of the video (10:40) is Ozone. 4 Kevin Fairweather Kevin Fairweather 3 years ago Very succinct explanation ! 1 EK Lim EK Lim 3 years ago (edited) "Dear GP, how to make my heart age slower?" GP: "you should ask a cardiologist" "Dear cardiologist, how to make my intestine age slower?" Cardiologist: "you should ask a gastrologist" "Dear gastrologist, how to make my whole body age slower?" Gastrologist: "you should ask a GP" 17 thexeesus thexeesus 2 years ago Hm, his current 2019 theory describes aging in terms of epigenetic decline which seems quite different compared to mitochondria-nucleus interaction. Although in both cases decline in NAD plays role. Just questioning how reliable is all these. 4 Mark Sze Chai Chan Mark Sze Chai Chan 6 years ago Thanks it is fascinating! 7 saxmanchiro saxmanchiro 7 years ago It's a hypothesis, not a theory, yet. This reminds me of Dr. Dean Ornish's idea, back in the mid 80s, of reversing heart disease with diet only, quickly. Many in the medical field scoffed at him and chastised him for his foolishness. Now we know the truth. He was right. Sometimes, a crazy idea in science gets ridiculed until the irrefutable evidence comes in. Could be a game changer for sure. 54 Chris McAulay Chris McAulay 7 years ago Incredible - now I just need to find a reason to live - lol 254 GrooveDoctor77 GrooveDoctor77 7 years ago I have tried Niagen about a week ago , Im still sceptical but, I have(had ) 3 loose teeth , but just yesterday I noticed 2 of those teeth have tightened by a large degree , the 3rd tooth is still loose but even that tooth has tightened ..so after week I have hopes that this product is working,(re edit (3/2015) after 2 months of Niagen...I am completely amazed at how well this works, I could list 7 or 8 improvements all over my body ...the most recent amazing thing is..I have been diagnosed diabetic for 5 years, I still eat the same ,.. but I have had to reduce my med intake (I probably will quit Glyburide soon) because my glucose levels were dropping to normal by themselves , I lost 8 lbs of fluid retention after the 2nd week... I am 165 lbs from 173, never realized the bloating in my face & body until I looked at a video from Nov 2014 & compared it to a video I made a couple of weeks ago..1 thing I can say...thanks Dr, Sinclair 12 Tomas Hull Tomas Hull 1 year ago Aging can't be stopped... Everybody dies... Some signs of aging could be slowed down and reversed... temporarily... The cell division processes breaks down eventually... the telomeres get shorter each time it happens... mutation load in increases with age... It's all driven by quantum mechanics... 3 pikiwiki pikiwiki 2 years ago I understood everything! 5 PROCESSOR302 PROCESSOR302 7 years ago You still have to stop cells going into senescence after repeated cellular replication. One way of doing this is to maintain telomere length. 21 Srtj.Av. Srtj.Av. 2 months ago I love when he smiles as is a good thing happening! 😊 bcbr bcbr 6 years ago But why do the nuclear and mitochondrial genomes stop communicating in the first place? What causes the nucleus to think that it isn't receiving enough energy? 7 Blue Jay Blue Jay 2 years ago (edited) what's calcitrol? i saw it in the the Closed Captioning. Mitochondrial Autophagy is caused by Parkin-pink1. Parkin-Pink1 attaches to a receptor on the outter mitochondria membrane. there's 2 types of autophagy. Selective Autophagy from pomegranate's elligic acid and a specific probiotic trigger selective autophagy and universal autophagy from Intermintent fasting. Autophagy is when a damaged mitochondria gets enveloped by a membrane with a libosome. And breaks the mitochondrion into amino acids. to be recycled back into the cell. selective autophagy is the type triggered by high ROS from damaged mitochondria.universal autphagy just autphagies them all, except the Mitochondria. beacause the mutant mitochondria don't.produce ATP. So no ROS by product. to help facilitate the bond of Parkin-Pink1 to the autophagy receptor on the outter membrane. i know South Korea has developed a healthy mitochondria injection method. and England has their mitochondrial donor program for three parent babies. Is there a connection between mitochondrial fuction and telomere? i wonder. 1 Kay Halsey Kay Halsey 3 years ago Thank you for the information. 2 spruceguitar spruceguitar 1 year ago "I do not want to live forever in the memory of the people. I want to live forever in my apartment." Woody Allan 7 joe schmo joe schmo 5 years ago The body likes to have a 700:1 ratio of NAD to NADH according to a video by Shallenberger. That shows how important NAD is. 2 IW Nunn IW Nunn 2 years ago I don't want to live forever. I just want to be healthy and live an optimum life while I'm in this body. 61 Sun Sun 3 years ago sleep, nutrition, movement, absence of stress, good emotions +++ 39 David Maletich David Maletich 6 years ago NAD levels can be raised naturally through caloric restriction and/or periods of intense exercise. Either of these separately or in combination create periods of negative energy balance within the body which raises NAD levels. There are some supplement companies out there such as Life Extension who market nicotine riboside as an NAD enhancer. I wonder how safe this would be for someone to take who is already engaging intermittent fasting/caloric restriction and/or a fairly demanding daily exercise regimen? 36 JAMES B. JAMES B. 8 years ago The first NAD+ supplement was just introduced by the same company that developed both the first high potency Resveratrol and Pterostilbene supplements, Biotivia LLC. It is by no means cheap but if it were it would probably not be genuine. The name of the supplement, which is extremely limited at this point in time, is Mitotrans. 2 Tenerezza jie Tenerezza jie 5 years ago (edited) I have a question.... If communication is so important, why didn't the communication evolve to become more "direct" physically instead of relying on shuttling proteins? Gerald's Videos Gerald's Videos 2 years ago Thanks for this. Reduce inflammation! 2 tigerkills tigerkills 2 years ago Every medical professionals should learn this. Sarge Sarge 2 years ago Isn't there a basic fallacy at work here... if we just learn enough about the tiny details of human health eventually some magic pill or molecule will emerge to fix everything? 3 Graeme Gladman Graeme Gladman 2 months ago You need to research vit K2 or and L - Citruline for its anti aging effects. It has wiped my wrinkles and made me years younger. I don't know which one is responsible or it could be a combination of the both. Watta Watta 7 months ago some free radicals are good for the body thats probably why u dont wanna remove all of them, but if they do damage dna then maybe thats something to look into فدان فكرت احمد فدان فكرت احمد 5 years ago Thanks it is fascinating 2 Hank Nelson Hank Nelson 2 years ago Something much, much bigger is needed, to absolutely be born again. This is a concept that goes beyond the real date of the pyramids. A perfect human is what may very well be locked away in our genes. But first we need to believe that he is there. Pamela RedPill Pamela RedPill 3 years ago Love it if we had a real treatment for mitochondrial disease... 3 Hainet Korea Corporation Hainet Korea Corporation 1 year ago Marine algae.Green seaweed(Chlorophyta) Ulva prolifera is a species of seaweed in the family Ulvaceae that can be found worldwide. Ulva lactuca(linza, pertusa, rigida) etc The pigment comparison of photosynthetic plants and green seaweed. The nine pigments based on chlorophyll in green seaweed are the same as plants. What is the structural color of green seaweed ? It is the color that appeared in the natural physiological and ecological environment when photosynthesis in the earth's environment. Nine Colors:Green,Yellow,White,Pink,Red,red-Purple,(reddish Brown-Brown),Blue,Black. The changes in the color of green seaweed are intended to communication with each other due to environmental conditions.(transformation of chromaticity and breeding of offspring) Who are the ancestor of life on earth ? Genetic and evolution of Earth life.(Eukaryotes: Mitochondria) Mitochondria are Alive:Dried, Bleached, Melted, Rotted(Black) mt DNA: Genetically, it has pigments information and Produces photosynthetic pigments. mt DNA: Nine genetic pigments(Rainbow colors and white, black) Nine melanin pigments(Skin, Eyes, Hair):Human, Marine and Land animals Benjamin Hardisty Benjamin Hardisty 7 years ago I do think, however, that there is way too much salesmanship in the aging field in general! That def. perturbs me. 10 kittyhooch1 kittyhooch1 2 years ago After this watch a recent video of him. Six years later he is visibly younger. 17 you r enough 💜 you r enough 💜 4 months ago Intermittent fasting can and will repair your midocondria and clean keto 🥰 Term limits Com Term limits Com 2 years ago (edited) Notice his eyes.... no jaundice like 75% of other people. Also look at his knuckles no edema no tremors and no mandibular deformation from poor dental health..... I trust him. Did you know he wrote a book on this in 2019? 1 Abraham Robles Abraham Robles 2 years ago The mitochondria is the powerhouse of the cell :) 16 Manuel Ojeda Manuel Ojeda 1 month ago I just turned 70 and I feel great. Splassshhh1234 Splassshhh1234 1 year ago I like the joy he has 2 Niagen Longevity Booster Niagen Longevity Booster 6 years ago Does it work or not? Nanoscience and cell sciences are booming now. In Boston alone the patent list is growing for new compounds and discoveries. This field is only going to grow. I see it everyday in New England. If you like drug stocks that come from new sciences look at Boston. (Home of Harvard and MIT) One thing I can say for sure is it helps me. 2 Shapan L Shapan L 2 years ago Interesting topic Doctor but it's very theoretical and still no technique or medicine or diet strictly to improve mitochondria function is available. One thing which I never understood about is free radical? According to biochemistry free radical is the driving force to all the enzymes in body to hasten the function so as to remove the free radical itself so in this process the function of the enzymes is constantly active not in silent mode so what if there were no free radical at all in carbohydrate or protein or fat metabolism ,won't the enzymes go in silent mode and since no activity would lead to death. Our body needs stress to stimulate and relaxation to calm down so that's why sympathetic n parasympathetic are created .... So please do make me understand about free radicals Doctor Thankyou 2 Tom Provan Tom Provan 3 years ago 2014 pretty old news has anyone an update? It is possible now to get all the supplements to keep the krebs cycle humming and the ETC working including adjusting the nad+/nadh ratio. I am sure lots f people have tried it. It would be interesting if they would post there results. Although the only test might be still healthy at an advancing age? Chad H Chad H 3 years ago There are a couple of unsettling things about this video "When we let mitochindria into our cells..." (as if we didn't enslave this species) "Except in my germ cells... in my testes..." [maintains eye contact] 3 Yuan Yao Yuan Yao 3 months ago He definitely looks younger now, wow 1 Grace 2U Grace 2U 3 years ago what about the supplement Ubiquinol( Co enzyme Q10) this is supposed to raise atp production? 2 Robert Robert 1 year ago Nice analogy, the mitochondria are all maternal. Perhaps they can be put in an hibernation state.. For space travel! Levizja per dije Levizja per dije 2 years ago Lelouch: Suzaku live. Suzak: Should i take NMN, Metformin and resveratrol like Sinclair. Code Geass 4 Splassshhh1234 Splassshhh1234 1 year ago INCREDIBLE 1 C B C B 3 months ago Where did alpha proteobacteria (precursor to mitochondria) come from, and how did they become part of us? How did humans create energy before this happened? Hank Nelson Hank Nelson 2 years ago The price for The NAD Treatment Center Detox Method can range between $6,000 to $17,000, depending on the specific program that is recommended for you and discussed with NAD Treatment Center staff. For reference, a typical 10-day treatment is $11,850. 2 Secret Soul Secret Soul 1 year ago (edited) We dont need to live forever, if we do, we are having lot of problems in coming. Plus we are not dying just bcoz of aging... Pandemic, accidents n killed... We not study aging to live forever Prof, but why aging science is important, its because aging related to many diseases. With our modern unhealthy living styles, we only look for remedies of the damages we have done. Study ageing is my favorite stuff but to live forever... Thats on diff page😂 Brendle Lau Brendle Lau 1 month ago So if i have less functionality of mitochondrial DNA or i dont make enough of it when young i would die of a lack of cells with enough energy to run a marathon, when i am older, i am so glad it will happen later than earlier in life, but when is the cut off point when mitochondrial DNA start to grow less useful Delia Ocampo Delia Ocampo 2 years ago No worries being serene contented in life eating healthy and financially sound the secret of looking young longer life 🇸🇽🇺🇸 Green Wealth Green Wealth 2 months ago Thank you very much. Kyle A Kyle A 5 years ago is it bioavailable orally? does it only restore muscles to a youthful state or all cells and that is just the example he used towards the end of the video? Jivoy Jivoy 8 years ago Very interesting 5 Ziya Onbashi Ziya Onbashi 6 months ago Sinclair looks younger now that he is 50 3 RedEyeification RedEyeification 2 years ago "You'll find the Truth and the Truth will make you free"...Jesus Christ VEE VEE 3 months ago I volunteer for that aging research!! Nicoleen Wentzel Nicoleen Wentzel 2 years ago I am 59 years old. My husband is 64. I feel like I am getting younger. I have lots of energy and are able to do 12 hours hard labor. My husband looks like a really really old man. I often wondered if I am too young for him or if he is too old for me. My whole life I had the idea that I am slow. It is strange and I could never really understand why I am years behind other people. I do catch up eventually but then they are old and I feel young. Today something just popped up in my brain: Micro Con dial. I had no idea what it is, so I googled and find this video by David Sinclair. Does this make any sens? 2 Khamis Zananiri Khamis Zananiri 4 years ago excellent.thanks 1 Andrew J Andrew J 3 years ago And they say Glyphosate is perfectly fine because it only affects a metabolic pathway of bacteria. mårten Sundling mårten Sundling 1 month ago His own appearance has also changed quite drastically if you look at him today, i swear, his five years younger today, five years later, so his own concoctions seems to work.. Delia Ocampo Delia Ocampo 2 years ago Mr.Sinclair only 50yrs.old just look his age no artificial and in the genes too looking younger 🇸🇽🇺🇸 Samuel Lopes Samuel Lopes 4 years ago I wonder if Antibiotics have a direct impact on mitochondrial dna? 2 David Cardano David Cardano 2 years ago If we are not living longer than we were ten thousand years ago then why was the life expectancy around 30 years in the 14th century? Alfred Hitchcock Alfred Hitchcock 2 months ago We live forever in heaven Zach Sicurelli Zach Sicurelli 11 months ago He looks the same age today. His regimen seems to be working a bit... 2 juntjoo nunya juntjoo nunya 3 years ago So where do you find this magical "NAD" in nature? Please say donuts 70 Emily Ingrid Laura Emily Ingrid Laura 3 years ago He sadly takes metformin instead of just addressing insulin resistance with intermittent fasting and Keto. 2 Lahzy Lahzy 2 years ago This is almost 6 years ago and he looks younger now... 43 Jonathan Hadley Jonathan Hadley 2 years ago What if the Mitochondria is damaged through Toxin exposure?! 2 Fatma Almarashi Fatma Almarashi 2 years ago I love anti aging science I am Amercan Board certified Endocrinlogist could you give some trading in this new science or rather do you offer fellowship in antiaging? 1 Chris T Chris T 2 years ago He claims he is 40 in this 2014 video... but i think he says he is 50, in a 2019 video? I believe his hair also looks thicker in recent videos, but face and brow may be less expressive like from botox or something. That, or he is successfully reversing aging on himself. 1 La Charmer La Charmer 1 month ago This video is from 2014, we have come a long way since then. Cocoa Cocoa 1 year ago why would you want to live longer than your species is supposed to? being alive is hard and moving on is important. 1 JC JC 11 months ago I thought this video was made in 2021, because he looks exactly the same today. Something's working. 1 Explore_with_sagan Explore_with_sagan 4 months ago (edited) I got mitochondria dysfunction at age 27 through gadolinium injection. Can't function without coq10. Still too weak IW Nunn IW Nunn 2 years ago An argument against monogamy!! 5 Shine Bright07 Shine Bright07 2 years ago Cyanide is in many Fruits....and B12, cyanoCobalamin, type of B12. 1 Ati Movers Ati Movers 2 years ago Creatine supplements can increase atp production. Any correlation to this topic? 3 Reed Wells Reed Wells 1 month ago If We Are A Combination Of 2 Species, Human Being 1, What Is The Other? joe schmo joe schmo 5 years ago Evidently Frank Shallenberger has known about this for a while, I think before 2013. 1 Samuel Lopes Samuel Lopes 4 years ago Ketosis increases NAD+ to fight off inflammation 7 F1Partisan F1Partisan 2 years ago reverse aging? that is like a child asking to eat candy forever! you can eat right and live well. If today was not enough then 2 hundred years will not . 1 Elizabeth John Elizabeth John 5 months ago Amazing E M E M 2 years ago note how this is from 6 yrs ago and david sinclair has not aged one bit... 1 DR Gunjan chaudhary DR Gunjan chaudhary 3 months ago And I did that 😊🙏❤️ spicaofla spicaofla 1 year ago mitoQ is the miracle supplement Arunava chakraborty Arunava chakraborty 3 years ago Who is making mitochondrion old.. probably some chemical ..and that chemical problem created by dna...that dna tell the chemical function to make mitochondria old so we have to find that dna who made the chemical function and made us old....simple and easy answer do study in dna...dna is making us old .....if I had money to study in aging..I would have cure aging ..fuk economy ..just because of economy i can't do study and helping human ..and cure my own aging.. 2 Rusty Cottrell Rusty Cottrell 2 years ago thanks for caring and sharing Gordon Seay Gordon Seay 2 years ago You don't hear the interviewer. Did they simply ask "hey, David, how are you?" and then he spoke for 13 straight minutes? :) 3 Zbigniew Brzezinski Zbigniew Brzezinski 7 days ago His projection didn’t materialize so far! Jane Roth Jane Roth 2 years ago Does NAD help people with MS? Vincent Napolitano Vincent Napolitano 5 years ago can intermittent fasting help repair our cells? 4 Fit Pro Fit Pro 2 years ago (edited) We need coq10 to make energy in the midcandria. 2 Li Li Li Li 4 years ago The best way in practice is still dietary restriction. 2 Zerry Lo Zerry Lo 4 days ago Red light LED come to the rescue. It cure my hepatitis B & C, allergy skin problem, nasal problem. CKJ CKJ 2 years ago Today it’s known as stem cell therapy. Problem is the “gold standard” clinic is in Panama with Dr Riordan. And it’s expensive. Khaldoon Aljerian Khaldoon Aljerian 1 year ago (edited) 0:55 "Not living much more than 10K years ago"....Bruh... we more than doubled our age! https://youtu.be/v3ncUYKme4k?t=55 Lorenzo Northern Lorenzo Northern 4 years ago This is 4 years ago. How it went with humans? 16 Mark Hedger Mark Hedger 2 years ago Reset mitochondrial function with sunrise and sunset bathing , Dr Jack Kruse 1 Glenn Decker Glenn Decker 6 years ago Many relevant experiments can be, and should be, using immunoelectron microscopy. I can help, if only through sharing my experience and ideas... Jason Bulsa Jason Bulsa 3 years ago Biochemistrical signaling. There are the preassembled supplies you need; make more NAD+ 1 Manuel Ojeda Manuel Ojeda 1 month ago I still teach piano 🎹 in a Music 🎼 Institute 37 miles from where I live. I don't take any Medication at all. Alex Menz Alex Menz 3 years ago What if we raise those nad levels in young people? 2 Manuel Ojeda Manuel Ojeda 1 month ago My neighbor's Mom is 80 years old, and she milks cows, was riding a horse daily in Mexico, she doesn't ride the horse anymore. She is strong as an Ox. tigerkills tigerkills 1 year ago L Dopa is converted to Dopaquinone and then to melanin by an Enzyme tyrosinase I think Vit k2 has something to do with it?. RAS in short RAS in short 5 years ago great S.L.S S.L.S 2 years ago I'm 73 yrs old, so I guess i'm screwed. That's ok 'cause I plan on living 'til I'm 107. 2 dee js dee js 1 year ago Eat mushrooms it feeds our mitochondria!! Salve regina 1 Rashid Ahmad Rashid Ahmad 2 years ago NMN cause elevated homocysteine. Please advise Gerson Freire de Amorim Filho Gerson Freire de Amorim Filho 2 years ago Great 1 Gio Sarran Gio Sarran 2 years ago Wow! mary ann carrlton mary ann carrlton 3 years ago Hence the mitochondria aren’t happy for many. 1 Bryan Sarver Bryan Sarver 3 years ago Ok what’s up with this niacinamide and nicotinamide are they the same? Please explain anyone Sherry Clement Sherry Clement 10 days ago When the test on humans? Maybe help delay some diseases? Rod Inz Rod Inz 4 years ago NAD+ !! 1 George Stephenson George Stephenson 1 year ago I really enjoyed your video. 8have life extension instruments edstud1 edstud1 4 years ago Sounds like marriage counseling for the cells? 3 Fon D Fon D 1 year ago Exactly Sid Michael Sid Michael 2 years ago NAD OR NMN OR RESERVATROL? Rebecca Jeffrey Rebecca Jeffrey 2 years ago And what exactly is the purpose of this long long term living? How does the earth sustain this?? 2 MzVirtue ReLoaded MzVirtue ReLoaded 8 years ago Hmmm... Interesting information. What if...? 1 eckankar eckankar 2 years ago One of the sexiest scientists out there. Crystal Dawn Creations Crystal Dawn Creations 7 months ago Whats a safe real NMN brand please? Tenzin Wangdak Tenzin Wangdak 2 years ago Wow NAD for nuclues nezir çağlar nezir çağlar 2 years ago mitocondria and aging.. Ingrid Ramey Ingrid Ramey 2 years ago Water in the mitochondria..? 1 Leonardo Rezende Leonardo Rezende 2 years ago This background is giving me trippy vision 1 tay Ya tay Ya 2 years ago if interested with those topics watch Jerry Tennant 1 tigerkills tigerkills 1 year ago Richest source of NAD is peanuts. Control your Future Control your Future 2 years ago You need more magnesium and a good kind too. You also need to go on a carnivore/keto diet. Add in some Alpha lipoic acid and MSM along with some bentonite clay, food grade to your drinks. ACV along with meals is a good thing and for god sake's get some son and some good vitamin D3 and k2... done! keto rocks. too much sugar is our problem along with drinking water now out of plastics. 3 Michael Jameson Michael Jameson 7 months ago SHSH nobody tell Bill Gates people might live longer he wont be happy. 1 Freedom Seekerz Freedom Seekerz 1 year ago I have the solution for this process. PM me. Its already been found. Maga Man Maga Man 11 months ago Where has this gone in 7 years? Nowhere! "Man, dust thou art and unto dust thou shall return." philip Alan philip Alan 2 years ago he seems so sincere. but its total bull 1 Fatma Almarashi Fatma Almarashi 2 years ago I mean training sorry for typo david farmer david farmer 2 years ago Why live forever? I lived in the 70s. Today just dont compete. 6 IW Nunn IW Nunn 2 years ago Don't think we'll ever fully understand the complexity of the human body Jorge Herrera Jorge Herrera 2 years ago Oh no marriage is broken and genome won't communicate omg there is no way you can fix either. Horrible bad news Perusing Person Perusing Person 2 years ago (edited) Total bullshit. You are really optimistic about amazing results of future testing of NAD precursors. What if you create problems? Crickets. Ethics? 2 Scott K Scott K 3 years ago Is it me? Or does he look like he's right on the brink of puking? 1 K G K G 6 months ago SIGN ME UP! I'll be your guines pig ;D Nubian King Nubian King 2 years ago What can we do now...what really work.to slow or reverse it now....nad.plus. IndianRailways IndianRailways 6 months ago Now you are 48 !!! Evan Hodge Evan Hodge 8 months ago (edited) Live forever - sadist. He's not interested in quality of life? We are NOT living as "we" did 10,000 years ago. Is he crazy? Alzheimer's? See Dr Dale Bredesen's work. 2021. Maria Trimboli Maria Trimboli 5 years ago doed the dr take it ? 1 Jorge Herrera Jorge Herrera 2 years ago Please please inject me with some nmd I'm 63 and I feel like shit. Where can i get some ? kipling1957 kipling1957 2 years ago Gimme, gimme... Scott K Scott K 3 years ago Something about this guy makes me feel uneasy.. 2 mary ann carrlton mary ann carrlton 3 years ago Well yeah ! 1 RILEY (SlotDog) PLAYS SLOTS (He's a dog) RILEY (SlotDog) PLAYS SLOTS (He's a dog) 2 years ago Dont tell my wife about this. 1 Silvia Gurková Silvia Gurková 2 years ago God is so mighty!! Everyone will die! I pray and hope that also you will trust in Jesus Christ and will have eternal life! You are very wise man, but be thankful to God, that he created you! 2 Huy Nguyen Huy Nguyen 3 years ago 10:32 1 Martin Sage Martin Sage 2 years ago Outdated info. WmTyndale WmTyndale 2 years ago BS Omega Point Singularity Omega Point Singularity 3 years ago hello Truth Teller. Truth Teller. 2 years ago (edited) Go read the Holy scriptures and you'll see the answer. You can explain and search but at the end of the day our life span was cut short by Jehovah God ---Genesis 2:17 - Genesis 3:19 . 1 Janice Green Janice Green 2 years ago