Sinclair - Cracking & reversing the aging clock - Frontiers Forum 2019 534,608 viewsJun 21, 2019

David Sinclair - Cracking & reversing the aging clock - Frontiers Forum 2019 534,608 viewsJun 21, 2019 8.9K DISLIKE SHARE DOWNLOAD CLIP SAVE Frontiers 31.4K subscribers Renowned longevity researcher David Sinclair believes aging is not inevitable but a treatable condition. In his talk at the Frontiers Forum 2019, he explained why we age – and how we can reverse aging to extend human healthspan and lifespan. David Sinclair is Professor in the Department of Genetics, Blavatnik Institute and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard Medical School. The Frontiers Forum is held in Montreux, Switzerland. See all speakers: https://forum.frontiersin.org 581 Comments rongmaw lin Add a comment... Carl Hopkinson Carl Hopkinson 2 years ago Wow, someone under 60 that actually sees value in older people. Amazing!! 129 Fizzedup Slade Fizzedup Slade 2 years ago Great speech. What an inspiration he is and all those involved in this work. 5 Karim Karim 2 years ago (edited) Fascinating! I am following Prof. Sinclairs advancements closely 👌 Mitochondria, Aging, and Health 22,525 viewsJan 11, 2021 481 DISLIKE SHARE DOWNLOAD CLIP SAVE Kinexum Services LLC Mitochondria are commonly referred to as the powerhouses of cells because they create the energy necessary for cell function; however, these organelles do much more than that within our bodies. At Targeting Metabesity 2020 (www.metabesity2020.com) this past October, an expert panel led by mitochondrial genetics pioneer Dr. Doug Wallace discussed the key role of mitochondria in aging and health. While other "hallmarks of aging," such as senescence and epigenetics, represent important targets for extending healthy longevity, mitochondrial dysregulation and sequelae, such as inflammaging, are at the heart of the complex of chronic diseases of aging called “metabesity.” Join our panel for an updated dive into one of the major drivers of aging and health. About the Speakers: Douglas Wallace, PhD, is a geneticist and evolutionary biologist at the Children's Hospital of Philadelphia in Pennsylvania, where he serves as Director of the Center for Mitochondrial and Epigenomic Medicine, and holds the Michael and Charles Barnett Endowed Chair in Pediatric Mitochondrial Medicine and Metabolic Diseases. More than 35 years ago, Dr. Wallace and his colleagues founded the field of human mitochondrial genetics, popularizing the concept of the ‘mitochondrial Eve’ from whom all humans alive today are descended. Wallace has a BS in Genetics and Developmental Biology from Cornell and a PhD in Microbiology and Human Genetics form Yale. Francesca Fieni, PharmD, PhD, is the founder and CSO of Pano Therapeutics, a platform biotech company she spun out of UCSF focused on clinical development of drugs targeting mitochondrial ion channels to address complex diseases of aging and extend health span. Francesca earned a PharmD and a PhD in Neuroscience from the University of Modena and Reggio Emilia, Italy and subsequently pursued a postdoctoral fellowship at Massachusetts General Hospital, Harvard Medical School in Boston. She was an independent research associate/specialist at the University of California San Francisco before she turned entrepreneur. Hazel Szeto, PhD, MD, is a research scientist, inventor, and entrepreneur in drug development. She received her MD and PhD in Pharmacology from Cornell and served on the faculty for 37 years. In 2016, Dr. Szeto left to direct research for Social Profit Network, a public charity supporting research to promote healthy aging and reduce age-associated disabilities. Dr. Szeto has developed the first class of compounds that selectively target mitochondria to enhance ATP production, repair mitochondria, regenerate tissues, and restore organ function. These compounds are now in clinical development sponsored by Stealth Biotherapeutics, a company founded by Dr. Szeto in 2006. Dr. Szeto’s research has resulted in over 200 peer-reviewed publications and more than 60 patents. Michael Zemel, PhD, is founder and CSO of NuSirt Biopharma, where he leads research programs focused on energy-sensing and development of therapeutics for diseases of aging and over-nutrition. Previously, he was Professor of Nutrition and of Medicine at the University of Tennessee from 1990-2012, where his work focused on energy sensing, muscle-fat crosstalk, and regulation of adipocyte metabolism. Prior to the University of Tennessee, he served on the faculties of Endocrinology and of Nutrition at Wayne State University and as Research Endocrinologist at the VA Medical Center associated with Wayne State from 1980-1990, where his work focused on endocrine regulation of cell signaling and downstream effects on both blood pressure regulation and insulin sensitivity. Dr. Zemel received his PhD in Physiology and Nutrition at the University of Wisconsin-Madison. 28 Comments rongmaw lin Add a comment... L T L T 7 months ago Please put together a podcast with scientists addressing the Western Diet effect on killing mitachondria. Example, Corn Syrup injected in everything. 4 Deffo radio Deffo radio 4 months ago Great work! 1 Viktor Nilsson Viktor Nilsson 1 year ago Great work guys. Very supricing about leucin 2 Mike Frame Mike Frame 11 months ago Dr.Douglas W fielding the question about Gilbert Ling was a special moment. around 1:18:00. Also 1:23:00 the question about EMF...wow. 3 Erwin Rogers Erwin Rogers 3 months ago Love it 🔥 1 thenewapollo thenewapollo 1 year ago @Claude, are you sticking to a dose of 75g of glucose or do you consider bodymass (smurf vs giant) in the administration? Evan Hodge Evan Hodge 1 year ago (edited) Useful fact: 1:45:00 non-panelist comment. HOW to check patient's insulin resistance. Evan Hodge Evan Hodge 1 year ago (edited) Exercise makes you insulin sensitive. Histamine evolved before the adaptive/innate immune system. What can you, in reality, check when you assess your health along the lines of mitochondrial function/energy production? That's the worthwhile question for a normal person. These people want to sell drugs. 3 CartesianColours CartesianColours 5 months ago Please put website links here. First speaker mentions website but it is not clear. Thank you. Hikari 8 Hikari 8 4 months ago (edited) Except Dr. Wallace, the panelists look so unhealthy. How can unhealthy people have any clue as to what makes a human healthy? Compare these people to Dr. Paul Mason, Dr. Brett Scher, Dave Feldman, Elliot Overton, etc. Just as I wouldn't take financial advice from broke people, when it comes to health, I wouldn't put much weight on the opinion of unhealthy people. 2 White Light Knight White Light Knight 7 months ago Humans do have brown fat 1 L T L T 7 months ago 42:00 metformin Timothy Bolton Timothy Bolton 1 year ago Curious - can or will a body take an electron and use it? Like grounding... can your body use an electron from the ground for something like this or does it have to be generated this way and stolen 2 Dino Miles Dino Miles 1 year ago Great , your all so smart . How about you tell us what we can and should do to enhance longevity, health , energy .... blah, blah , blah . Doesn't mean shit , if we cant implement positive change . 3 teleport valorant teleport valorant 11 months ago Hi everyone.If you read this message please read the Holy Quran the direct words and the final message from God.It will guide you to peace truth and happiness in this world and the afterworld with my lovely wishes 3 Dino Miles Dino Miles 1 year ago Next slide ... yup. Dino Miles Dino Miles 11 months ago Junk ... skip it . These filled are lost . 1 Dino Miles Dino Miles 1 year ago Junk seience... harmful. 1 28 Andrew Haze Andrew Haze 2 years ago This is great information. I am a student of health and fitness. At 71 I feel great. 28 T's L'il Bear Shoppe T's L'il Bear Shoppe 2 years ago Excellent! Thank you for all of your hard work in this area! 5 John m John m 2 years ago Thanks doctor you’re doing a great humanitarian job for the improvement of mankind and history will remember you and generations to come will be greatly for your efforts 11 Ramsey Pietro Nasser Ramsey Pietro Nasser 1 year ago If aging could be reversed safely and effectively, then this would be a galactic event. We can travel the stars 11 Shem Believer Shem Believer 2 years ago Can't wait to start his book Lifespan! Thank you Dr Sinclair. Yes I want to live on this Earth a purposeful healthy productive life as long as God has chosen for me. I didn't get to decide when I was born nor when I'll die. No epigenetics can protect me from the angel of death and my final breath. Personally I would not wish to stretch over 90/100 even in the healthiest state, that is more than enough of this very ephemeral life lol so unfortunately the science doesn't take into account spiritual dimension. Achieve 200 or more years for what purpose exactly? And will Earth be a better place to live in? 7 Ben Clark Ben Clark 2 years ago This is awesome! The downside is there are some corrupt people who society would not do well to have around that long. 2 Wesley Wesley 2 years ago I'm not interested in dying, but for everyone who wants to die I wont try to stop you. Hopefully this anti-aging research will expand lifespans dramatically, and I am optimistic that we can simultaneously deal with the environmental and social consequences that will arise from this development :) BK BK 2 years ago MY EXPERIENCE I was doubtful but desperate and this is what happened to me and totally unexpected. I stared doing intermittent fasting by skipping breakfast. I got on PQQ20mg, resveratrol, NR 250mg, Cycloastragenol 25mg on a empty stomach first thing in the morning. After about six weeks I noticed I could not sleep for more than 7 hours and thought this was interfering with sleeping BUT I realized my body no longer required to sleep longer and I could work all day into the evening without any fatigue Like I used to when I was younger. Loose skin under my neck started to tighten and also on my face which was a surprise. My eyes started focusing much better on small print. When I go for a light jog I know I can push much farther than before where I usually run and walk intermittently. My balance has improved where I can walk on a beam instead of falling off. I started dreaming almost every night very intensely. My male body is doing weird things that I haven’t experienced since I was 18. All I can say is something is happening that has never happened before with anything else and I have not changed anything. I eat very healthy organic non-treated food and I don’t eat junk but the change has to be because of this because that’s all I have done different and if this is only the beginning I am looking forward to 3 months supply I can’t what to see what happens but this is my experience which I am did not expect or plan for because nothing else has done anything but my energy was gone and I was getting weaker and felt wobbly and health slipping away. I was good till I hit 60 and then started noticing a change downhill and that’s happened to everyone in my family. I saw that early so I made changes at a very young age and it still came on no matter what I did until I tried this. Things that matter. Get the pesticides/roundup and chemicals out of your food, get the weight down by replacing junk food with natural food your body can recognize, drink pure clean water filtered, Lower high carbs and sugars, do a light jog every day. When you get desperate enough and scared you will be willing to try this like I did and hope your results will be the same before it gets too late. I don’t know if it’s the combination I’m taking and the way I’m taking it or what but it may have something to do with increasing the speed and effect I am having. 62 thatwasprettyneat thatwasprettyneat 2 years ago i guess this might sound naive to people, but this man gives me hope. also, i think what he's talking about is not fanciful--it's only fanciful in the context of a history without the knowledge that we have today. aging is inevitable, but the deterioration of the body may be fungible, or even negotiable. the challenge would be to figure out how to structure society if and when that happens. 8 Hector Cabeza Hector Cabeza 2 years ago Great video, thank you for the information and the hope 5 John Wendland John Wendland 2 years ago Followed Sinxlair for years...he never told anyone what he was taking until recently...he must be on the cusp of a breakthrough that will make what he has been doing moot 21 Benjamin Martinez jr Benjamin Martinez jr 3 months ago Love this guy ,. I'm trying to figure out why I still look how I did twenty years ago ..I just turned 41 Juan Carlos Gutierrez Betancur Juan Carlos Gutierrez Betancur 2 years ago Excellent as always! 5 Philip King Philip King 2 years ago I've gotten excellent results with Nicotinamide riboside 450 mg per day,300 mg in the morning, no breakfast.150 mg with lunch, my energy level and stamina are 100% better,my eyesight has improved dramatically, mental focus is 100%. I'm 51 ,construction worker,and can only verify what has worked for me.I hope everyone gets the results I have,the difference is amazing. 105 Lazarus Blackwell Lazarus Blackwell 1 year ago We can all make life so much better Why should we accept anything as the "way of things"? There is no reason for that. Accepting disease as something normal is just a poor excuse for not wanting to work to solve that problem You don't have to work Just keep a positive mind and show some gratitude for those who make lives better 4 Jane Lawrence Jane Lawrence 2 months ago I will be 50 on my next birthday, but many people still think I am still 30+. Very overwhelming but all thanks to NMN by vitruvin. Along with balanced diet and regular exercise, it's definitely possible to improve the quality of living and slow the aging process. 2 Janika Mahmud Janika Mahmud 2 years ago astonished how can people dislike it! anyways very thoughtful indeed. need to skip a meal, especially at night and definitely would try to fast at least two days a week. •HermHerm• •HermHerm• 2 years ago I have been taking NMN and Pterostilbene for 5 months and feel great. Arthritis almost gone. More energy quicker recovery sharper mind. Family and friends also the same. I’m 54. My 83 year old dad now does 50-60 pushups a day and can work outside 6-9 hours. Huge improvement. And both out cholesterol have improved. 20 michael Scaturro michael Scaturro 2 years ago that's brilliant, equating concepts of communication theory to biology. Wow. 9 Old Guy Old Guy 2 years ago If you watch his older videos (10 years ago) on the internet, you don’t see him get old at all. 11 Anna Redelinghuys Anna Redelinghuys 2 years ago David, i am really thankful for all your time and effort. Thanks again .. I would like to know if my husband can be helped he is going blind and it is so sad to see because he is such an active man . He is a diabetic and it has attached his eyes he has gone blind in the right eye and has about 30% vision in the left ..I would like to surprise him with a possible cure 1 Drale L Drale L 2 years ago From childhood I always said I would Live forever, or die trying. Now I see vindication over the horizon to all who were laughing at me. I did take the quote form somewhere though I can't remember where. 5 Jack Roth Jack Roth 2 years ago (edited) Dr. Sinclair, Sir, please, let's get this show on the road. I'm 75 and I damned sure do not want to be the last human to ever die. In the future mankind will look back on the time when we all had to die at some time. I'm running out of time. I have a good life and I want it to continue. Also, I am busy, I don't have time for death. So sir, please let's get this thing going. 15 Vitruvius Vitruvius 2 years ago This guy is coming out with a book in 2020..Definitely going to read it. 9 John Brown John Brown 2 years ago he's right, we should have put all the resources in anti-aging !"! Danni Phillips Danni Phillips 2 years ago I am 65 - I run 5k almost every day, I do a weight routine, martial arts and this year I have returned to playing baseball 40 Rick Murie Rick Murie 2 years ago Wow. Perhaps I speak for many when say I'm not nearly so afraid of dying as of the possible ravages of old age leading to death. 18 Fina Khan Fina Khan 2 years ago There is German technology that introduces frequencies, vibration and resonance because it’s the language and key to longevity. Patrick van meter Patrick van meter 2 years ago Help everyone to see climate change take us all out. That said, I like this just in case. Lifespan, fascinating read. Curt Zimmerman Curt Zimmerman 1 year ago I have been taking nmn,1 gram a day for about 3 months now. Also taking reservatol. Can’t really say I see a difference but will probably give it another 3 months. At about $130 a month I hope to see a difference to continue. 1 Klaus Zoidberg Klaus Zoidberg 2 years ago what happens when you take NMN for a year and then you interrupt the intake for 2 months or so? Does anyone know this? 6 rutr wer rutr wer 3 years ago this guy is close to 51 what ever he takes i want it. 294 John Travolta John Travolta 2 years ago I'm 27 years old and I'm really interested in talks about aging. I think we humans have now bigger activiments and so to have a chance to active those goals we must live longer. 4 Eifion Phillips Eifion Phillips 2 years ago It's all down to collagen too and sugar reduces collagen so take collagen capsules, cut out sugar and derma rollers are amazing for bringing new cells to the skin reducing wrinkles, lines and sagging skin! 1 GO GREEN GO GREEN 2 years ago Causes of aging: 1. Mitochondrial dysfunction. 2. Telomere shortening 3. Epigenetic changes 4. Mutations. 5. Aggregation of proteins. 6. Glycation. 7. Oxidative stress. 8. Enviromental factors. 144 Carmen Tongson Carmen Tongson 2 years ago Wow he looks so young....amazing....looks like he's only in his mid 30's! 1 Women of God Women of God 2 years ago ☝️☝️☝️❤️❤️❤️❤️thank you for your information bluejackscanada bluejackscanada 2 years ago He looks like a healthy 50 year old, he is not fat and likely has good genes to start with. I applaud his effort to actually reduce biological age. I hope he can reverse aging, its terrible. If it were not, cosmetic companies would be looking for the fountain of aging. krm398 krm398 2 years ago my question would be..at what cost? can normal working..or retired people afford such a thing? or will it be so costly that only Bill Murray or someone like him can benefit? 3 Fauzia rahman Fauzia rahman 1 year ago I am waiting for this.i hope it comes in my lifetime. 5 Husham Ahmed Husham Ahmed 2 years ago روووعة هذه ستكون ثوره في تاريخ البشريه 2 One Sun One Sun 2 years ago Listened to the whole thing because he looked young at 50. 42 Irina Andrea Irina Andrea 2 years ago Wow ! He talks the walk ! If he really is 50 but looks 30 then I am a believer 1 Christina M Christina M 2 years ago This guy looks incredible for 50. 81 Devon Mckay Devon Mckay 2 years ago Me: we all getting old David: im about to rewind this mans career 5 Chris Hax Chris Hax 2 years ago Since I was young I have fasted and eat one larger meal a day usually and have always thought it helped my body's metabolism remain slower than others and now it's becoming accepted as healthy. My ego is being overfed now :) 11 Nubian King Nubian King 2 years ago What really work to turn back time...david... William Fields William Fields 2 years ago If Nmn can improve life of yeast, i would assume that it can improve the function or life of bacteria as well. iI that’s the case what are the long term effects of helping bacteria like helicobacter pylori (H. pylori)? or other Bacteria that can cause things like, Coronary artery disease? Our water in Florida, has this flesh eating bacteria called Vibrio. Most people can fight it off, but if I’m taking this…..Am i helping any of those bacteria to further spread?. 11 James Humphrey James Humphrey 2 years ago this combined with Neuralnet and there may be some hope for the human race 22 Ivan Break Ivan Break 2 years ago he doesn't look older since his first ted talk Glenn Thorn Glenn Thorn 2 years ago Great work David on your work ,Please can you focus on, affordability and access . why educate when these subs are for the privileged few 1 Women of God Women of God 2 years ago I would love to reach 120 why not if God allows me to live the long My grandpa is 100 years old and he still here with us 5 Pugger 653 Pugger 653 2 years ago I understand that over a very long period of time you brain will become overloaded with information. So that would make living for eternity impossible. But I also have these “theories” where you can come up with some method to have self induced amnesia on memories that are deemed unnecessary such as a former relationship that didn’t work out. Or even death of family members so you don’t need to have the pain of the loss. Maybe far enough in the future we gain the capability to transfer are consciousness into some software and then gain the capability to store memories that we don’t need at the moment, so we can draw upon the memory’s when we need them. Then again these are just some things I thought up after listening to this video. This video had me thinking for a good half an hour over possible futures. Robert T Robert T 2 years ago His "vision" of what is coming is pretty mealy mouthed. Is it virtual antiaging, or is it not? I'm all in for that. But he keeps hedging what he thinks is possible. burritos burritos 2 years ago I do intermittent fasting. It's cheaper than medications. 109 Evaristo Grant Evaristo Grant 2 years ago Only thing is that the average age of death is the same as it was more than two thousand years ago. 3 score and 10 (70). Upon searching Google it gave 71.5. Hmmm. How are we really living longer? carla de almeida carla de almeida 2 years ago great guy! Anita Carrier Anita Carrier 1 year ago Metformin? All pharmaceuticals are acidic, this causes inflamation. Aging in my view is about free radicals which cause oxidative stress, free radicals are unstable molecules because they are missing essential electrons, therefore they scavenge electrons from cells causing them to deteriate. Excessive exercise causes oxidative stress, exercise shoukd be moderate and consistant. Antioxidants donate electrons to free radical molecules stabling it and preventing scavenging from cells. Madben 99 Madben 99 2 years ago I'm close to 70 and have been following his 'protocol' for at least 6 months and had high hopes based on his lectures and supposed research ( on mice). I have experienced NO benefits what so ever. He's selling snake oil, folks. He has some interesting rodent results and has spun that into a personal fortune by his lectures and startup longevity companies. 14 Grox44 Grox44 2 years ago I wish I could afford NMN. I think there is evidence showing it works. Wish I could at least try it for a year. 5 Sydney Hamilton Sydney Hamilton 2 years ago Make eternal youth happen to both humans and animals! 5 bogrunberger bogrunberger 2 years ago So you'll have to work even longer, great! But seriously there are several issues with this, over population perhaps being the most important one. But another one is that assholes will also live longer and get more experienced. Cindy Radison Cindy Radison 1 month ago Honestly, I just don't want to be a wrinkly grey-haired useless woman who can’t remember stuff in my ripe age. If I can get older and be able to sustain my body slowing down aging or even biologically reverse aging to my prime, that is ideal. Obviously, nobody can live forever, but I feel like we can live a lot longer, so why not slow our age rather than age slowing us down? This is why I am constantly taking Dr. Sinclair’s NMN, a NAD booster and indeed a health provider. With NMN Vitruvin Nutrition (500mg) a day every morning with protein drink and Greek yogurt, it has radically changed everything. All sorts of problems have disappeared. Now, age is just a number. 2 Vince Abbott Vince Abbott 2 years ago Let’s get real about this if you have good genetics you will look younger. I have always been told I look ten year younger then my age.Yes I do eat right and go to the gym . The thought of making it to 100 is nuts. There is no need to go that long unless you want someone to feed you and change your diaper, your quality-of-life is about zero. Patrick king Patrick king 2 years ago i am going to live forever, i already figured how to keep young looking inside and outside the natural way. Sheetal Kelkar Sheetal Kelkar 2 years ago People living that long is a scary idea! I appreciate my life because the fact that it’s temporary 3 KittyCat Land KittyCat Land 1 year ago salute doctor i need This Erich Kiparski Erich Kiparski 2 years ago The crazy thing is that this guy’s schedule is extremely demanding/grueling and he probably looks like his version of “shit” in this video. Imagine what he looks like when he is rested and relaxed. 😳 John John 2 years ago This is going to be the start of the zombie apocalypse! 9 Jypsea Moon Jypsea Moon 2 years ago Very intriguing Max Freedom Max Freedom 2 years ago "We can now help you live longer and healthier." Yep. It's called diet and exercise. 1 MajiMarji MajiMarji 2 years ago I’d like to meet his dad! 3 Edilberto Rivera Edilberto Rivera 2 years ago So fasting is actually effective and healthy. Isn't that written on a 2,000 year old Bible? 7 martin sinclair martin sinclair 2 years ago We all now know it works. Online even every pharmaceutical company in China won't sell the powder for less than $3,000/kilo. It goes up to $5,000 depending on where you check. I can buy a kilo of cocaine in Quito for $2,000. When will the price come down to reasonable levels? David Kozelsky David Kozelsky 2 years ago But what will happen to the planet if everyone lives too long? 3 Galliano Marr Galliano Marr 2 years ago How many mg of Resveratrol does he recommend daily? Mortgage Financing Mortgage Financing 2 years ago (edited) great salesman !!!! 1 IncognitoTorpedo IncognitoTorpedo 2 years ago (edited) I've got some bad news for you. Even if you get epigenetically reprogrammed to a younger age, you will not look much younger. You will be metabolically healthier, but your UV-damaged skin will not repair itself, and it's unlikely to fix adrogenic alopecia. I hope I'm wrong about this, because I have my share of damage, but I'm not holding my breath. It did repair that crushed nerve, which is promising, but that's not the same as older damage. A more relevant test would be to try to regrow an old nerve injury. A young epigenome still isn't going to know how to repair a glycated protein, or remove scar tissue. 1 Dee Jay Dee Jay 2 years ago This just screams design NOT evolution مها الهذلي مها الهذلي 2 years ago ترجمه العربية متى تنزل؟؟ Longevity Coach Longevity Coach 2 years ago Insulin is not only the aging hormone, its also the hormone will be produced when we consume carbs , tea, coffee, cigarettes, bread, pasta etc. but not when we eat meat or drink water. Well 12 months ago I stop producing insulin so now I only eat meat and drink water. Thats the price to pay for health and longevity. 14 Malvin Ooi Malvin Ooi 2 years ago (edited) Many people said I look 42-43yo. But I am much more older than that +12. Few important practices are the follows...... 1. FASTING IS ONE OF IT TO TRIGGER THE IMMUNE FOR YOUNGER CELLS. 2. VIT B IS NEEDED TO PROTECT AND REBUILD NERVES. 3. ONLY FOR THOSE WHO ARE INTERESTED..... 4. Only for those who are serious..... 5. Only for those who needs to..... 18 Jon skelin Jon skelin 2 years ago This guy does not look 50yrs old as stated at 9:48 of this video. That is a good thing. That means that the stuff he is using is working. Jerry Ridge Jerry Ridge 2 years ago The question is, where are these trillions of dollars saved from? It seems that the patient is spending the trillions of dollars. Follow the money! For years we donated to the cure for cancer. If they are any closer to a cure I would be surprised and no matter how much you donated when you get cancer you have to pay to be treated not cured in remission. Angela Asadi Angela Asadi 2 years ago Do you know where I can purchase NMN at an affordable price? It runs about $100 a month for a gram a day. Not sustainable for most of us who have kids in college. 15 A Ras A Ras 2 years ago anyone over 40 reversed gray hair with any treatments? please share. Sandiz Sandiz 2 years ago Im 31 soon to be 32, i want to start an anti aging program and Reverse my biological clock, any suggestion on What i should begin with? 3 Dreamliner Dreamliner 2 years ago He looks younger than he was 7 years ago ... check his older video Marcelo Temer Marcelo Temer 2 years ago "MR BOY" - James Patrick Kelly's short story from 1997. 3 Tom Kruze Tom Kruze 2 years ago I thought he was early 30s not 51. Something is working 258 Winston Chang Winston Chang 2 years ago Wow ! David Sinclair looks the same, if not younger, than that video he did on mitochondria some years ago.....Was it just Resveratrol,....what about Pomegranates...? Cheryl Gies Cheryl Gies 2 years ago Maybe his dad is experiencing a placebo effect. The mind is very powerful. We under estimate our brains. 3 Majella Ertel Majella Ertel 2 years ago I wish to reverse my age and look 18 again. How do i do this? 8 Galliano Marr Galliano Marr 2 years ago What are examples for NAD Boosters? gabard jean-paul gabard jean-paul 2 years ago He was born in Australia 🇦🇺 1969 ... 7 Himalaya Himalaya 2 years ago but the actual thing is "we want to die but just look like 20 all life long😅 tbvh. 2 Pierre Normandeau Pierre Normandeau 2 years ago Scientist easely forget that healthy living and purity of the blood and organs is also the main determening factor in staying young and living longer. That is why people who live in polluted cities live 5 years less than people who live in the country. People who are vegetarian and avoid alcohol live 5 years longer on average than meat eating people. People who exercise regularly and stay at normal weight livre 5 more years than overweight people .You should question a biologist about the benefits of fasting on water. Biologists know much more about health than any medical doctor.. Fasting on water is a universal and simple way for people or animals to purify the blood and prolong a healthy life... 4 John Newby John Newby 2 years ago You lost me at "global warming " Timothy Tassone Timothy Tassone 2 years ago Expect major pushback from big pharma. They don't want to funnel solutions. It's all about options and money. 48 Steven Hughes Steven Hughes 2 years ago Sounds like Lazarus Long from Robert Heinlein....he did exactly that... lived a life then revuvenated. 3 Caffeine Tablet Caffeine Tablet 2 years ago 0:34 Is he asking "How many of you would like to return to 20?" The damn audio skipped. Andrew Heath Andrew Heath 1 year ago (edited) I have listened to a number of his talks, and in the final analysis there is NO breakthrough. Only ‘maybe’ medicines coming. Only practical advice given for NOW, is not new: fasting , eat well, no smoking, exercise. Or can someone assist me in some other practical anti / reverse ageing strategies? What information can be recovered and how? Mary Cate O'Malley Mary Cate O'Malley 2 years ago I envision you cracking the code just in time for the ecosystem to collapse. KONGNO2000 KONGNO2000 2 years ago i beleive that physical immortallity is possible ... 5 Satnam Sandhu Satnam Sandhu 2 years ago why live for 120 years when you can live for eternity? 42 킴룰렛 킴룰렛 2 years ago 최고 plejaren1 plejaren1 2 years ago So does pine bark extract and grape seed extract- same thing. 2 tjkooks tjkooks 2 years ago What is the use if all the right ingredients are not providing to the public. Big corporate companies want to make money do not really care if we live healthier and longer life. I have heard him before and tried to get the resveritrol that was working on with his team to learn later that his research was sold to a big pharmaceutical company. As usual the market was saturated with unreliable products sold to the public as natural supplements that is beneficial to the public. What people do not know that unreliable products can cause lots of health issues some like pancreatic cancer. I am tired of listening to all that. If you guys can not backup all that with reliable sources then we do not need it. Edgar Wilson Roial Edgar Wilson Roial 1 year ago So how can we take in Yamanaka factors? Stephen Mcbean/Cummings Stephen Mcbean/Cummings 2 years ago Please hurry with reversing the ageing process. DallasPilotCar DallasPilotCar 2 years ago I want some of the molecule. Maria Maria 2 years ago Veganism helps with aging but it would be nice to live untill death with a youthful appearance and with more energy 1 Wil R. Wil R. 2 years ago Actually if you go look at his older videos he looks older lol Danny Dazzler Danny Dazzler 2 years ago Great way to insult everyone with the first thing he said. 2 Margarida Carrancho Margarida Carrancho 2 years ago how will that have effect on women's fertility? 1 Josephine Alquinto Josephine Alquinto 2 years ago We are just passing through in this life so don’t derail it.....it’s so much better on the other side.. marcos g salgado marcos g salgado 2 years ago Have they stopped aging. In San Antonio texas every young person turns old very fast and very fat Andreas Georgallis Andreas Georgallis 2 years ago Paul Rudd has probably done it, why don't we ask him? Lyla N Lyla N 2 years ago No way he is 50. I need what he is taking please. Where i can find it 12 Pamela. Nam Pamela. Nam 2 years ago I bet you a dollar, your father won't live to be 100 . No matter what his blood said. I have a friend who is 119 who looks better and not living on pills, not even thinking about longevity and such. His parents died within 3 months of his birth, and all his other relatives. He is currently working on impregnating his less than 50 years old wife. Manuel Ojeda Manuel Ojeda 1 year ago Also look at Carolyn Hartz who is now 71 And she looks 46 years old. cadwell Collins cadwell Collins 2 years ago where can we find NMN and at least try it 3 حياة واختبارات حياة واختبارات 2 years ago And make the road our home No thanks I want to go home someday Spearmint Spearmint 2 years ago what was it his FATHER did to stay young now??????? John Smith John Smith 2 years ago Is it possible to learn this power? 2 peanut12345 peanut12345 2 years ago Forced fed pills for every action of the Human Being is a major cause,Shhh, Pfft BECKFORD BECKFORD 2 years ago guys making a lot of money from our insecurities. 1 Dia Dia 2 years ago He looks 30 or lesser Dogbertforpresident Dogbertforpresident 2 years ago It seems he has reduced life to information. 3 Mari Brunnsteiner Mari Brunnsteiner 2 years ago (edited) He looks like 28 - 35 y.o 15 Himalaya Himalaya 2 years ago this guy is 50😅 2 Timothy Landers Timothy Landers 2 years ago Stick your medicines & profit! Natural buddy boy!!!!! Anchan Sony Anchan Sony 2 years ago wonder Warren Buffet's secret of longetivity despite living on 5 cans of COKE and Mc_Junk almost every day fladave99 Mills fladave99 Mills 2 years ago All these old people living forever. We will run out of Oatmeal! 37 PAXOG PAXOG 2 years ago NANO BIO TECH THTS A GREAT AREA FOR STAYING YOUNGER . 2 Brian Murphy Brian Murphy 2 years ago Wayyyyyyyy to complicated. I don’t have a p h d in any thing It’s taken him many years to learn all this and I can’t consume it in a short talk 1 Davey Doodle Davey Doodle 2 years ago That’s it? Thought he might say take some vitamin c Jane Bond Jane Bond 2 years ago Anyone ever told U that U look like Christian Slater? Thanks for sharing. I would love it if U would post the words & names of things since I can't spell very well. Thanks again. 2 Samuel Uche Samuel Uche 2 years ago Yes he looks young at 50 but I will actually look younger than him at my 50. 4 Daniel Purdy Daniel Purdy 2 years ago Stop with all the talks and focus on research David. NMN, resveritrol, fasting and that’s it. You’ve found nothing and no significant studies to back them yet. Get to work in the lab not traveling and giving talks. Pinaki Bhattacharyya Pinaki Bhattacharyya 2 years ago Unlocking the Secrets of Longevity: 20 Year Anniversary of Aging Research at Einstein 14,793 viewsFeb 12, 2019 169 DISLIKE SHARE DOWNLOAD CLIP SAVE Albert Einstein College of Medicine 63.1K subscribers (November 07, 2018) Nir Barzilai, M.D. welcomes the adult children participating in the Albert Einstein College of Medicine’s Institute for Aging Research studies of centenarians, their genes, families and history of disease, to learn what they have uncovered in the course of the past 20 years. 00:18 Dr. Barzilai presents the Longevity Genes Project findings, 41:45 Sofiya Milman, M.D. presents the findings of the LonGenity study, which focuses on the children of the centenarians, and 01:01:12 cardiologist Anna Bortnick, M.D., Ph.D., presents on new technologies that are keeping hearts healthier as they can harden due to aging. The focus of the ongoing work is to target aging as a health risk, to help both those with and without longevity gene mutations to live longer and healthier lives. Along the way, the presenters unravel some of the mysteries of aging. 01:14:21 A question and answer panel follows the speakers. 21 Comments rongmaw lin Add a comment... GGS GGS 2 years ago In my childhood I was convinced that my body would not die one day. I still think so! Time passed and today, at the age of 71, I am sure that Dr. Nir Barzilai was born to deconstruct the disease called aging. I'm so glad about that! 18 Jordan Ong Jordan Ong 2 years ago I would be honored to join them. It would make myself, my friends and family being young forever again. Richard Price Richard Price 2 years ago (edited) Can I enrol? 1:43 really important ! Thankyou exercise for me despite broken right elbow on the 29th Nov need the pins K wires removed Lonnie Satterfield Lonnie Satterfield 1 year ago I can't agree with the test that supposedly showed no difference that lifestyle had among people with the centenarian's genes and those without the genes. Then the assertion was made that people without the desired genes could benefit themselves with longevity by the proper lifestyle. If exercise and dietary measures can help one group the common sense tells that it can help ANY Ricardo A. Seneris Ricardo A. Seneris 7 months ago You could also use some Japanese in Japan since they are also homogeneous. Richard Price Richard Price 2 years ago Smoking disgusting habit , Exercise -sleep -nutrition and regularly taking time out from eating, plus all the other stuff deeper down pyscho social lifestyle , chance to interact and engage even as we age , significantly contribute to society, good old Pablo Picasso was case in point a rebel but still innovator! Madison One Madison One 2 years ago Chronological & Biological Age are not the same. Repeat that please. 3 Wilfred Mikolas Wilfred Mikolas 3 years ago ...."still at infancy in preventative therapy"..,really after 20 years it seems the same questions but no answers to speak of.Irving Kahn might have more answers than this panel. Richard Price Richard Price 2 years ago EXERCISE isn't really discussed perhaps because inertia to exercise as we age is difficuilt nor SLEEP , VitC-lysine protocol ? Peter Peter 1 year ago Good talks, but don't understand why the slides starting at about 52 minutes are considered telling given he poor p values. Michael Ju Michael Ju 2 years ago Stop vitreous aging and liquefaction first peacock821 peacock821 2 years ago Where can I buy resveratrol rice, DJ526 rice? Richard Price Richard Price 2 years ago Great BUT THE BIG PICTURE IS MULTIDIMENSIONAL isn't it ? Richard Price Richard Price 2 years ago (edited) X ray not an accurate analogy 4-6 months + CAT scan rubbish , 4-6 months condensed and had all in the space of a few minutes or more , ionizing radiation is used to prematurely age mice and why because it sinesces cells so successfully. Growth hormones intuitively usefull for isolated sites and muscle growth but body builder polmboism or distended stomach seems directly due to ingestion of growth hormone .? Yes MRI is that more or less risky than Cat scan. YES exactly first the test is it safe? If so then how invasive , then how to read it and then correlate with other info , it is a huge problem but YES marketing today internet so-called experts saying this or that about health and l;ongevity they are muddying the waters . Also, my advice would become self-aware of the whole body -mind t process and traut in that wahtever you call it God or Higher power to guide you God bless shalom. Julia Dixon Julia Dixon 2 years ago How does a 50 something woman in decent health, w no vices, get into one of this guy's studies? Can become Jewish if necessary. 6 Rijen Shahi Rijen Shahi 3 years ago Dear doctors, i would like to suggest you that if you are still on research then please do it on Asians cause i think Asia have more centenarians then any others. I am From country Nepal and i still remember lots of centenarians in my family when i was child but now from the same family lots of members are dying mostly with diseases like blood pressure,Strokes, etc, could you answer why this could be? 2 Rifka Pinner Rifka Pinner 1 year ago 0