#metformin #rapamycin #Aging Metformin, Rapamycin & TAME Project | Dr. Nir Barzilai | Albert Einstein College of Medicine 11,545 viewsAug 31, 2020 581 DISLIKE SHARE DOWNLOAD CLIP SAVE Modern Healthspan 24.7K subscribers #metformin #rapamycin #Aging #Healthspan #Lifespan #Longevity #NirBarzilai Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later Dr. Barzilai’s New Book - https://amzn.to/30MOsGT Metformin, Rapamycin Studies |TAME Project : This is the part 2 of our interview series with Dr. Nir Brazilai from Albert Einstein College of Medicine. Dr. Barzilai is the founding director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai discovered the first longevity gene in humans and has since discovered several others. In addition to his “longevity gene” research, Dr. Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He is also investigating the physical and mental declines associated with aging and how they affect longevity. He is the author of over 270 peer-reviewed papers and a recipient of numerous prestigious awards,including the recipient of the 2010 Irving S. Wright Award of Distinction in Aging Research and is the 2018 recipient of the IPSEN Longevity award. Dr. Barzilai’s New Book - Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later, the No.1 Best Sellers in Physiology section in Amazon, reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. In this video Dr. Barzilai talks about some of the drugs that can effect the way that we age, in particular metformin and rapamycin. He introduces the TAME (Targeting Aging with Metformin) trial and discusses how the current pandemic highlights the need to better understand and combat the effects of aging. Link to the TAME trial at AFAR https://www.afar.org/tame-trial Ted Talk Links for Dr. Nir Barzilai How to die young at a very old age | Nir Barzilai | TEDxGramercy https://www.youtube.com/watch?v=TsA4S... Ageing is a treatable disease | Nir Bazilai | TEDxBeaconStreetSalon Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health. Products or services mentioned in this video are not a recommendation. Disclosure: Some of the links provided are affiliate links. Although we may receive a small commission from the affiliate, the cost of the product for you will always be the same, or often discounted. Thank you for supporting our channel! https://www.youtube.com/watch?v=XN7rL... Can we grow older without growing sicker? | TEDMED https://www.youtube.com/watch?v=MGKB9... 72 Comments rongmaw lin Add a comment... FiftyPlusBeauty FiftyPlusBeauty 1 year ago Great interview! Thanks. I’ve been watching your youthing videos with great interest. I just started Niacinamide and Metformin and will also be doing a set of YouTube videos on anti-aging. Thanks for sharing your journey. I appreciate you and watching your videos.🎉 4 Iggie Dalrymple Iggie Dalrymple 9 months ago I'm 82 and started taking metformin before it was legal in the US. I recently took my first dose (6mg) of rapamycin and intend to repeat that dose every 10 days. Am in good health except for asthma and am mega-dosing on vit D3 in hope of controlling my asthma 3 Modern Healthspan toby9999 toby9999 1 year ago Excellent interview! As others have commented, your channel is quickly becoming one of my favourite resources related to anti-aging technology. Please continue your solid work, and know that you're reaching an increasingly wider audience. Thank you sincerely. 1 Dan O'Hanlon Dan O'Hanlon 1 year ago You have had sone excellent guests on your videos. This is another brilliant scientist who can speak in a way we can all understand. Thanks — much appreciated! 5 Modern Healthspan Jose Jr. Jose Jr. 1 year ago I read David Sinclair also a member of the TAME Trial. I absolutely hope this project will be a success one! 5 jorge rodriguez jorge rodriguez 1 year ago Thank you so much for bringing this vital information to us. I've seen a couple of your other videos and progress. I don't want to discourage the use of metformin but, I read that if the kidneys are not functioning properly, metformin can build up in your system and cause Lactic acidosis. I was just given my first Metformin prescription, and will start my dosing very soon. 2 bb v bb v 1 year ago Your interviews are the best being uploaded currently! 7 Renee Ren-Patterson Renee Ren-Patterson 1 year ago Two questions: How does evidence the Metformin make the cells younger? Do you have a standard test to get results, do you found that individual genetic variants affect the results?? Thank you for the video to open new idea.. 1 Shirleen Frailich Shirleen Frailich 1 year ago This all great. Thank you for doing it. We know though regulators love to regulate. If we had the cure to whatever ails you, regulators would want to regulate it. So how are you going to get around this nonsense and broken academic medicine? Please let make suggestions as follows: 1) For each center, publish the cost per patient. 2) For each IRB, publish the time it takes from protocol submission with consent to time of approval. 3) List the IRBs that refuse a single common IRB (so they can get the IRB smarty pants award and run up bills). 1 Neylson Braga Neylson Braga 1 year ago DOES NIR BAZILAI'S DOSAGE OF 1,500mg CHANGE IN CASE OF USING extended release format? 2 steve myers steve myers 11 months ago thank you - great interview would have liked a longer conversation re rapimycin 2 Modern Healthspan metropolitanrise metropolitanrise 1 year ago Great work, I am taking metformin, too. 4 Radha Blinderman Radha Blinderman 1 year ago Great interview! Thank you for this video! 1 David Hanson David Hanson 1 year ago I take both metformin and weekly rapamycin. The metformin has a side benefit of lowering blood glucose that the rapamycin tends to raise. It seems that rapamycin has helped lower my fasting glucose level but raised my post prandial glucose levels. I use a glucose meter to carefully monitor glucose after meals and I just don’t eat the foods that raise the glucose higher than I desire. 9 mahmud rizaldi mahmud rizaldi 1 year ago Great explanation and informatif...! Thank's. Modern Healthspan Jessica Jessica 1 year ago Unfortunately I’m in my 40s in the US, and I don’t have diabetes, and a internist MD / doctor who asked me this Summer what a microbiome is. So, I have to take Berberine instead. I really wish doctors were keeping up on these studies, especially since drugs like metformin have been around already for 60 years. Does anyone know of any doctors in the US who are willing to have remote patients and give metformin? I’ll even pay out of pocket. Or a reliable manufacturer who will sell and ship internationally? 1 Gokhan M Gokhan M 1 year ago I'm on 500mgx2 Metformin. , 6mg/week Rapamycin. So far so good. 2 Modern Healthspan Barbara Walker Barbara Walker 2 weeks ago I was on Metformin 500 mg for 9 months and my creatinine levels increased to abnormal levels. Not good for my kidneys. Al Keegan Al Keegan 1 year ago It's such a shame metformin is prescription only. I'm taking berberine now but feel it's a bit of a poor man's cousin in comparison Lord Mon Lord Mon 1 year ago Dr Barzilai said the billionaire who funded him was starting a foundation to fund anti aging at $1 billion per year and would be announced in January 2021. Anyone hear anything yet? 3 A C A C 3 months ago Ashwagandha, Triphala, Haridra. These are prescribed in Ayurveda for longevity. There are cases of humans living more than 200 years in India taking these. But there's a way to take them - time of day, in what form they are taken (in alcohol / with pepper and other herbs etc). Bill99 Bill99 7 months ago (edited) Another "risk" to the government is a public policy issue, i.e. if we increase average lifespan in the US population, the Social Security program would quickly go bankrupt. This is also true of corporate and union pension plans. 1 Patricia Cell Patricia Cell 1 year ago Fantastic Andriy Stoperkevych Andriy Stoperkevych 1 year ago You know it is not possible to get metformin without doctors prescription. Can I consider a berberine as 100% metformin's substitution? Susanne Uhl Susanne Uhl 1 year ago I tried to get Metformin from my doc but he refused because he says is bad for your kidneys... 2 kenneth ayres kenneth ayres 1 year ago My DR only has me on 500mg dayyyyyyyyyyyy Aldi Lee Aldi Lee 7 months ago How to take the metformin? unchartedexe unchartedexe 2 weeks ago Great guest, awful interviewer. Literally staring at his email notifications instead of paying attention. Ruth Horowitz Ruth Horowitz 1 year ago I take Berberine. I would rather take a natural supplements than a pharmaceutical. 1