Should healthy people take metformin? (benefits vs. negative exercise effects) | Rhonda Patrick 101,011 viewsPremiered Feb 4, 2020

#Fasting #KevinRose #Supplementation Should healthy people take metformin? (benefits vs. negative exercise effects) | Rhonda Patrick 101,011 viewsPremiered Feb 4, 2020 2.1K DISLIKE SHARE DOWNLOAD CLIP SAVE FoundMyFitness Clips 57.6K subscribers Longitudinal studies showed that people with type 2 diabetes taking metformin lived 15 percent longer than healthy controls not taking the drug. This raises the question as to whether the longevity benefits of metformin may extend to healthy people. However, metformin may inhibit exercise-induced benefits, such as cardiorespiratory fitness and gains in lean body mass. In this clip, Dr. Rhonda Patrick gives her thoughts on whether healthy, active adults should take metformin. Listen to the full episode on the Kevin Rose Show: https://podcasts.apple.com/us/podcast... Study: https://www.ncbi.nlm.nih.gov/pubmed/2... About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California. She has done extensive research on aging, cancer, and nutrition. It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach. Learn more about Dr. Rhonda Patrick and her mission for FoundMyFitness at www.foundmyfitness.com #Fasting #KevinRose #Supplementation 359 Comments rongmaw lin Add a comment... FoundMyFitness Clips Pinned by FoundMyFitness Clips FoundMyFitness Clips 2 years ago Listen to the full episode on the Kevin Rose Show: https://podcasts.apple.com/us/podcast/dr-rhonda-patrick-new-omega3-sulforaphane-research/id1088864895?i=1000461297039 More clips from Dr. Rhonda Patrick: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gJAebLkHTAf09y4i7g8Hag8 7 Nesli Efendi Nesli Efendi 1 year ago I’ve been taking merformin for 7 months and it’s greatly improved my health and training. I’m sure the training improved as a result of my health improving although I’m not sure. I’m training harder, feeling stronger and have more endurance, needing less caffeine, dropping weight and haven’t seen any negative effects to muscularity. I have not done anything different besides add the merformin and don’t take any other chemicals. 30 John Lockett John Lockett 1 year ago Thank you for this video. I am 81 and I do take Metformin. My diabetes 2 started about 10 years ago. My Dr. and I starting working to change that outcome. I started taking Metformin 1000 mg, exercising and dieting. My weight was about 88 kgrms.. I am 5'.7". I started exercising on a treadmill. (Set at 3 which at a higher point I will start to run), 30 minutes 6 times a week. The Metformin reduced my appetite so much that after 18 months the doses went down to 500mg. After about 30 month I starting loosing weight and I stopped at 75 Kgrms. My diabetes 2 disappeared, but I still taking Metformin. This medication still affect my appetite, so I stop taking it for about a month and restart again. Dr. for me it was the exercise and loosing the weight. 75 kgrms is my weight when I was 21 years old. Metformin help me by reducing my appetite and now I eat smaller portions. I think it is all about the weight. 11 JMC JMC 10 months ago We need to take into account the effects of low IGF-1 levels in longevity through lowering MTOR. If Metformin can indirectly reduce IGF-`1 to less than 145mg /dl through suppression of MTOR, then the reduction of all-cause mortality from lower IGF-1 via suppression of MTOR in older persons may play in longevity - Perhaps a more important one. But has anyone looked into sarcopenia induced by Metformin as we age? 6 Jerry Dougherty Jerry Dougherty 2 years ago Always excellent analysis of a rather complex topic. Thank you for all your amazing work 🙏 3 Alexandre Magalhães Alexandre Magalhães 4 days ago (edited) I exercise every other day and was planning to take metformin after David Sinclair said he took it in the days he didn't exercise. I'm still searching about it. Thank you for talking about these randomized trials, Dr. Rhonda Patrick. Dr. Nancy McClure-Galli Dr. Nancy McClure-Galli 2 years ago Thank you for your always informative clip on Metformin. Tell me has anyone responded to the study recently published in Jena, Germany and reprinted by the Cold Spring Harbor Lab "Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism"? The conclusions based on C elegans mainly are: Late life metformin treatment limits cell survival and shortens lifespan. Metformin exacerbates aging-associated mitochondrial dysfunction causing fatal ATP exhaustion. Old cells fail to upregulate glycolysis as a compensatory response to metformin. The dietary restriction (DR) mimetic response to metformin is abrogated in old animals. PKA and not AMPK pathway instigates the early life DR response to metformin. Stabilization of cellular ATP levels alleviates late life metformin toxicity in vitro and in vivo. Could you comment, please. Always interested in your input. Nancy McClure-Galli, M.D., MPH 16 Aubrey J. Tennant Aubrey J. Tennant 2 years ago I appreciate Dr. R’s default organic proclivities. Especially if your under 60 considering the upside potential to downside risk dynamic. I’m 67 and an exerciser. I almost started Metformin a month ago and because I am not type 2 diabetic - I’m kinda glad I couldn’t get it here in Canada with a prescription. Dr. R’s honest perspective is cautionary but well presented I think. 9 JT Schnow JT Schnow 2 years ago I have/had type 2D and have been on 2000mg of metformin for 2 years. I lift weights and it has turned me into a beast. I believe metformin + weights has a synergistic effect. Current AC1 6.1 down from 10.4. 8 Dennis Fink Dennis Fink 2 years ago We need some professionals like Rhonda to review the research on the 20 to 40 fold difference in lifespan of the Queen Honeybee compared to the worker honeybee that is attributed to being feed royal jelly for slightly longer. Dr. Nessa Carey discusses this as an epigenetic effect in a four year old You Tube lecture on epigenetics! 5 matt sinabi matt sinabi 2 years ago Can anyone correct me on this? As I understand metformin only blunts the muscle hypertrophy and the cardio-respiratory fitness effects of exercise. The other exercise health benefits, like increase in telomere length or decrease in body fat percentage are not blunted by metformin. Thanks in advance! 10 Millenial Kingdom Millenial Kingdom 1 year ago I am not pre-diabetic and taking extended release metformin changed my life. Due to the fact that it decreases appetite, I was able to make changes and eat healthier. I have minimum side effects on the XR. Skin is pulling tighter, same benefits as when doing IF. Love this med. 17 Gaz Gaz 7 months ago At 5:48 Rhonda refers to an old study done in 2014 where rats with T2D were given the following doses 30mg per body weight, 100mg per body weight, and 300mg per body weight. I weigh 60kg. So if I were to take any of those doses I would be taking either 1800mg, 6000mg or 18,000mg. These are huge doses - I'm currently taking 425mg and am not diabetic. I feel fine and have not noticed any decrease in my physical performance. I have no plans on increasing the dose. But the question remains: If Metformin reduces one's chances of getting cancer by 31% (see FoundMyFitness Topic - Cancer) isn't this reason enough to take it??? 7 moestietabarnak moestietabarnak 3 months ago (edited) Since I've been diagnosed with T2D recently, I binge watch many video on all related matters.. from What I can gather (not a medical person in any way, but listening to Dr. Lustig and Dr. Fung and other) Metformin suppression glucose simply simulate the effect of fasting and low carb diet. It make more sense ... And since fasting is in our millions years adaptive evolution, We get the benefit without the risks associated with these drugs. and cheaper than free !( less food to buy heh !) I'll tend toward that more natural process. thank you + other benefit, our metabolism regain regulation without drugs. Why keep paying big pharma ? 1 HealthAndFun HealthAndFun 1 year ago (edited) If you are not diabetic and just taking metformin for longetivity, don't take on exercise days as it reduces performace as well as inhibites protein synthesis. Take on rest days 24 hours before your next training session, and take the fast acting metaformin. Also you can take Berberin instead. 2 Faisal Rafique Faisal Rafique 3 months ago I have recently started Berberine. I am non diabetic so there is no change in my glucose levels even after eating 500 mg x 3 per day. My digestion has got improved since Berberine helps with leaky gut problems. I felt more energy when I started taking it and now that it has become a norm so I don't fee the difference anymore. David Edwards David Edwards 2 years ago Has anyone seen anything that relates Berberin to reduced exercise benefits, since it's main mechanism is reducing and stabilising glucose level in the same way as Metformin. I have now stopped Metformin after listening to one or two of Rhonda's podcasts about exercise and Metformin not being synergistic. 6 fayiz shaffaq fayiz shaffaq 1 year ago She’s got answers to almost every question I have 1 Nuthan Maharaj Nuthan Maharaj 1 year ago Thank, you have shared critical information and have clarified many issues regarding weight loss. Victor Da Silva Victor Da Silva 2 years ago Good stuff dr Rhonda. I was taking Berberine with a fasting glucose of 95. I’m going to stop. Andrew W. / NH Andrew W. / NH 2 years ago Interesting finding....so Metformin potentially disturbs / upsets the Electro Chain Transport itself? Also the cardio AND lean muscle mass strengths reduction as side effects are particularly worrying.... Would combining Metformin and caffeine helps offset the AMPK inhibition? What about Chromium Pico or other insulin mimickers like Vanadium? Would be interesting also what happens if Metformin is used as TKD approach... 1 kineticx kineticx 1 year ago Very important questions answered, thanks for such informative talk IvorMektin PoxTheMonke IvorMektin PoxTheMonke 2 years ago N=1 here. I took metformin for a couple of years, my neighbor gave it to me. It really does lower blood sugar. I started weights last year and could barely make any progress until I dropped metformin. Months later I added creatine and that made a huge difference. 13 Bradbo3 Bradbo3 2 years ago Im 50 yrs old and Im type 2 for 9-10 years now...and on metformin. But 2 years ago I got serious and really hit the gym and watch my diet extremely close. Lost all the weight and KEPT it off and my A1C is 5.7.....daily glucose readings are normal and my Dr said Im no longer type 2 but wants me to keep taking it. I think Im better off without it....cant imagine how much better I could be physically without the metformin holding me back. 3 5DollarShake 5DollarShake 2 years ago I strength train mon/tues and thurs/fri , and I've recently added metformin on sat/sun to attempt to make me very insulin sensitive for when I push carbs on training days , I just began this experiment last weekend but I will soon see if my performance takes a turn for the worse or continues on its trend upwards 4 Joel McCoy Joel McCoy 1 year ago Dr. Rhonda Patrick has upped the quality of the nutrition conversations of English speakers. This is great. Richard Rivera Richard Rivera 2 years ago That’s incredible to hear, the point about healthy people who exercise taking Metformin. According to Dr. David Sinclair , who uses it personally in a study he is conducting within himself has stated that there is a synergistic effect. However, he understands that the pharmaceutical industry is the main cause of wrong dissemination of information. So who should we believe? I’m with Dr. Sinclair on this one. I am willing to conduct my own personal study under proper medical supervision. What do I have to loose? The potential to live 15% longer, healthier is a good incentive. 14 JK JK 2 years ago Madam, I don't like cardio exercises(trademill,running, ellipticals).I do lot of bodyweight squats,pushups, weight-training,Yog,basic pilates. My query is : do the exercises I am doing give me increase in glucose,insulin sensitivity ?at present,I don't have diabetes, hypersensitivity etc.i am 63years,male,live in India. 3 La Luna La Luna 1 month ago I don’t think I have ever felt worse than taking Glucophage 500 mg for a week. Severe asthenia, myalgias, GIT issues, dizziness… DeRiddler DeRiddler 10 months ago I have been sick with Myalgic Encephalitis for 17 years now. Exercise is not an option for those of us with this disabling disease. I have just recently added metformin to my treatment routine. The keto diet was very effective in helping me lose the 75 pounds I gained when I got sick. Most of that caused by the exercise intolerance which is a symptom of ME. Even on a very strict keto way of eating by blood glucose is rarely below 100. It was much higher when I weighed 75 pounds more, along with my total cholesterol and triglycerides. Only time will tell if metformin will replace the 30 miles a week I ran and the 30 one arm push ups in my routine before I got sick. 1 Ketogenicinfo Ketogenicinfo 2 years ago But, if you're chasing autophagy wouldn't Metformin and excersise be beneficial since they both inhibit MTOR? 12 Norwood reaper Norwood reaper 1 year ago Metformin and syrosingopine have been shown to work synergistically to work with each other to potently have an anti cancer effect. Syrosingopine also “was” a very good drug to also lower blood pressure. Why is it that syrosingopine is not even on the market anymore, it would be an awesome part of an anti-aging stack. Is it possible to request anti-aging websites like agelessrx to somehow source that I wonder🤔. Paul Beauchemin Paul Beauchemin 2 years ago Over the past 5 years I’ve smashed my shoulder and broken my hip while exercising both required surgeries and a year to recover. Will take the metformin thanks Ramil Magerramov Ramil Magerramov 2 years ago Thank you for this clip. Was just considering taking metformin. 15 Dave Larson Dave Larson 1 year ago I have a hunch that metformin combined with SAD is what causes the negative exercise results. Perhaps too much stress put open the systems. It’s like consuming fat: Works well when avoiding sugar and eating lots of leafy greens. A person’s diet should be a factor in a controlled study in future trials. In 5 years, excluding diet as a major factor in research might be no brainer. The reason it isn’t now??? 2 Brent McCulloch Brent McCulloch 2 years ago Berberine is often compared to metformin as a natural substitute, and some studies have show it's equally effective. I'm curious if berberine has these same non-synergystic effects with exercise as metformin does. 12 蔡哲光 蔡哲光 2 years ago 500mg metformin and 500mg niacinamide in the morning, moderate exercise and pre-breakfast exercise/stretch seemed work well for me! 12 itd itd 1 year ago What if I've already improved my aerobic exercise capacity to my limit, then started to take metformin? Andrés Grases Andrés Grases 2 years ago The interesting question (or answer for that matter) isn't "Should healthy people take metformin?". What I would like to know is "Are healthy people getting any NET benefit from taking metformin, compared to those who do not take it?" 6 David de Ridder David de Ridder 1 year ago Hi Rhonda, can you please do an update on Methformin. I really want to start taking something to increase lifespan. What is the latest knowledge on this front? 14 Robert Carlson MD Robert Carlson MD 1 year ago Has anyone looked at using just a small dose of metformin combined with exercise? A healthy person without DM2 may not need very much to get mainly the good effects and minimize the bad... ??? karel1331 karel1331 2 years ago Could you comment on Berberine? If the same negative effects are seen about the preventive gain in lean mass?