Attia with Sinclair :How cellular reprogramming could slow our aging clock, & the latest on NAD 16,198 views Jan 13, 2020

#70–David Sinclair, PhD: How cellular reprogramming could slow our aging clock, & the latest on NAD 16,198 viewsJan 13, 2020 Peter Attia MD 128K subscribers Full title: #70 – David Sinclair, Ph.D.: How cellular reprogramming could slow our aging clock (and the latest research on NAD) Original release date: 9/9/19 In this episode, David Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, returns to the podcast to discuss the content of his new book, Lifespan: Why We Age – and Why We Don’t Have To. This conversation focuses on the biological mechanisms involved in what David terms the Information Theory of Aging which provides insights into the “clock” that determines our aging and to what degree it can be manipulated. Our discussion on aging of course leads us into interconnected topics of epigenetics, sirtuins, cellular senescence, as well as what compounds David is personally taking for his own longevity. Additionally, we discuss the most up to date information related to NAD and longevity by looking at the potential benefits (if any) of supplemental agents (NAD precursors, NR, NMR, etc.) that pose a promise of increasing NAD. We discuss: -SIR genes and cellular identity [8:45]; -Sirtuins regulate gene expression [14:30]; -DNA is methylated at the deepest layer of the epigenome [17:45]; -Methylation pattern and determining cellular age [20:15]; -Cellular reprogramming [33:45]; -Yamanaka factors to push cells “back in time” [41:00]; -Human cellular reprogramming viability [57:00]; -Measuring the rate of aging [1:02:45]; -Cellular reprogramming for longevity [1:14:45]; -Compounds David takes for his own longevity [1:29:15] -NAD precursors (NR, NMN) and pterostilbene [1:40:00]; -The current field of sirtuin activators [2:03:15]; -David’s artistic work [2:05:15] and; -More. Show notes page: https://peterattiamd.com/davidsinclair2/ -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle 21 Comments rongmaw lin Add a comment... Jim King Jim King 1 year ago Fantastic interview. I cannot believe people in this thread complained about Mr Attias interviewing skills. This interview was as if we were invited to an amazing dinner party and were allowed to sit at the table between Mr Sinclair and Mr Attia. The conversation is brilliant. Thank you Mr Attia for your work. I love your passion. Based on your previous conversations in other interviews I created my Peloton name “KickAss100YrOld”. Thank you!! 10 Rob Flow Rob Flow 1 year ago David Sinclair is the most amazing person I have ever known not personally but by doing deep research on his findings and reading his amazing book I have learned more than I have ever thought possible soon I'll be trying what he is talking to know what exactly is doing to his body I have faith on him 4 Endre Endre 9 months ago (edited) Mr. Attia is an awesome thinker and I love how he manages to break down and guide Mr. Sinclair towards simplifying and explaining missing know-how of the viewers and later to being able to paint a full picture towards us. I think this interview is fully understandable for people with good basic logic skills. 2 summer shannon summer shannon 2 years ago Awesome interview Peter. Learned a lot more interesting info on this podcast. Thanks a bunch! 5 David David 2 years ago Great to see you moving content onto YouTube too Peter. Please do post more of the full podcasts not just the Qualy's. 7 Lelija Roy Lelija Roy 2 years ago The book is awesome...and this interview adds an important detail dialog. Thank you. 7 mark faulk mark faulk 2 years ago This was a great interview. Dr Attia asked the right questions to get most out of the interview. 1 Seabound Seabound 1 year ago This was a great interview! Many thanks! 2 helen mary helen mary 5 months ago I really much enjoyed the social impact and concern for harmonious development. Thank you so much jim buchanan jim buchanan 9 months ago Excellent discussion a a a a 1 year ago Extraordinary interview...... Dino Miles Dino Miles 1 year ago Dr. Bruce Lipton on you tube 15 years ago . Epie genetics front runner and discoverer. Eyes mind heart and soul wide open no fear... 1 Jamie Nelson Jamie Nelson 2 years ago Thank you, awesome interview! roscorude roscorude 2 years ago The interrupting by the interviewer disrupted my understanding of the guy being interviewed. A bonus from that is I'll listen ten more times. 5 Rui-9-CS Rui-9-CS 1 year ago 💕💕💕 1 Ethics&Existentialism Ethics&Existentialism 1 year ago Peter says he highly values his listeners, but in another podcast said he never reads you tube comment, which to me says he doesn't care less what his listeners think. He has great information but frequently interrupts his guests... Talks over the top of them in nearly every interview. It is very annoying and rude! He would benefit greatly from listening to the many listeners who have provided the same feedback but pity he doesn't care what we think. 🤨 2