Conversation with Nir Brasilia on Metformin by VitaDAO 923 views Streamed live on Oct 28, 2021

44 VitaDAO 1.47K subscribers VitaDAO Discussion Panel - Metformin: A healthspan extending drug? Speakers: Nir Barzilai and Tim Peterson Hosts: Max Unfried and Morten Scheibye-Knudsen Outline: 00:00 Intro 01:32 The history of Metformin (Nir Barzilai) 03:15 Metformin and aging 06:42 Evidence of Metformin effects on animals 11:45 The baseline difference in how we age vs mice 14:05 At what age should Metformin administration begin? 16:12 Metformin clinical trials and progress 24:15 Reviewing and getting a clinical trial going 27:15 Targeting Aging with Metformin (TAME) Trial costs 29:10 Longevity and cryptocurrency overlap 30:32 The science behind Metformin 37:20 The mechanisms of action of Metformin on diabetes 40:05 Alternatives to Metformin (SGLT2, GLP-1) 44:38 Therapies working together 48:58 Caloric restriction and Metformin 51:22 Neurological diseases and Metformin 52:38 Improving Metformin molecules 56:06 Side effects of Metformin Q&A 58:45 Dosing in non-diabetics that regularly exercise 1:01:15 Crowdfunding crypto mechanisms 1:04:09 Closing Dr. Nir Barzilai’s Book Age Later: Health Span, Life Span, and the New Science of Longevity https://www.amazon.com/Age-Later-Heal... VitaDAO is the world’s first decentralized intellectual property collective, funding and commissioning research into human longevity. Participate in the VitaDAO community! ⇛ Website : https://www.vitadao.com/ ⇛ Discord: https://discord.com/invite/3S3ftnmZYD ⇛ Telegram: https://t.me/vitadao ⇛ Twitter: https://twitter.com/vita_dao Chapters Intro 0:00 The history of Metformin (Nir Barzilai) 1:32 Metformin and aging 3:15 Evidence of Metformin effects on animals 6:42 The baseline difference in how we age vs mice 11:45 At what age should Metformin administration begin? 14:05 6 Comments rongmaw lin Add a comment... Michael McCord Michael McCord 6 months ago Great panel! 4 VitaDAO Fawn Rosenberg Fawn Rosenberg 4 months ago Did Dr Nir B say it needs to be I/V , not oral metformin, to be antiaging in non diabetics? Justin P Justin P 6 months ago What do you say to Reason of Fight Aging's argument that Metformin will have little more effect than caloric restriction? 2 David Howard David Howard 4 months ago Boring