David Sinclair How to Not Die ,May 3, 2022

How to Not Die | David Sinclair | Knowledge Project 136 47,598 viewsMay 3, 2022 The Knowledge Project 66.8K subscribers Biologist and genetics expert Dr. David Sinclair is out to prove he can live past 100 years old, and he thinks you can too. On this episode Sinclair goes in-depth on the process of aging and the techniques you can incorporate into your life that help you live a longer, healthier life, including optimizing your diet, the benefits of exercise, the role of a positive attitude, the importance of sleep, the three supplements he takes every day, why it’s never too late to slow the process of aging, and so much more. Dr. Sinclair is a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and he is best known for his research on aging, with a focus on epigenetics. He’s been called one of the 100 Most Influential People in the World by Time, and in 2019 he released the New York Times bestselling book, Lifespan: Why We Age – and Why We Don't Have To. -- 00:00 - Intro 01:24 - What is aging? 02:52 - What happens in our body during aging? 06:10 - How fasting decreases aging 15:00 - On eating three meals a day 18:39 - The best things to eat to reduce aging 23:05 - Organic v non-organic foods 27:04 - Should we only eat food that's "in season?" 29:46 - On sugar 31:42 - How to test your biological age 33:22 - Using exercise effectively 36:18 - Sleep and aging 40:36 - The benefits of saunas and hot tubs 45:04 - The relationship between stress and aging 47:55 - How positive attitude impacts lifespan 48:34 - NMN, Athletic Greens, and resveratrol 52:57 - Why David quit dairy (and did it matter?) 58:00 - When should you start slowing your aging process? 01:01:05 - On puberty and aging 01:02:53 - Are biological problems becoming engineering problems? 01:08:54 - Using drugs to reverse aging 01:11:24 - On lyme disease 01:17:06 - On hip-replacement and increased death rates 01:21:36 - How to think about aging before it's too late 01:23:30 - What's the ultimate age we can live? 01:28:30 - Second-order effects of living longer -- OUR FREE NEWSLETTER: https://fs.blog/newsletter/ 📈 OUR MOST POPULAR INTERVIEWS 🎬 The Full Story of Naval Ravikant: https://youtu.be/mGY2To_HW98 🎬 Bill Ackman - Getting Back Up: https://youtu.be/mIS3LYxgVWc 🎬 Secrets to Healthy Relationships with Esther Perel: https://youtu.be/atXKntdX2UY 🎙 Listen to the show iTunes: https://podcasts.apple.com/us/podcast... 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The Knowledge Project Pinned by The Knowledge Project The Knowledge Project 2 weeks ago Timestamps: 00:00 - Intro 01:24 - What is aging? 02:52 - What happens in our body during aging? 06:10 - How fasting decreases aging 15:00 - On eating three meals a day 18:39 - The best things to eat to reduce aging 23:05 - Organic v non-organic foods 27:04 - Should we only eat food that's "in season?" 29:46 - On sugar 31:42 - How to test your biological age 33:22 - Using exercise effectively 36:18 - Sleep and aging 40:36 - The benefits of saunas and hot tubs 45:04 - The relationship between stress and aging 47:55 - How positive attitude impacts lifespan 48:34 - NMN, Athletic Greens, and resveratrol 52:57 - Why David quit dairy (and did it matter?) 58:00 - When should you start slowing your aging process? 01:01:05 - On puberty and aging 01:02:53 - Are biological problems becoming engineering problems? 01:08:54 - Using drugs to reverse aging 01:11:24 - On lyme disease 01:17:06 - On hip-replacement and increased death rates 01:21:36 - How to think about aging before it's too late 01:23:30 - What's the ultimate age we can live? 01:28:30 - Second-order effects of living longer 12 Sophie Sophie 2 weeks ago Fantastic interview. I've watched many interviews with David Sinclair and this was the best by a long mile. You've definitely got a new subscriber here! 9 Grant Burris Grant Burris 2 weeks ago David, I follow all your talks. I have for about two years. I liked this one better than the ones with the guy who has the silly hat. This was well done. Just my opinion. Thanks for all the information you have been supplying. It very useful. 16 Adil Duredoran Adil Duredoran 13 days ago What a great interview and the host has been extremely patient and asked great questions 👍. Subscribed 9 MJ Grant MJ Grant 8 days ago great interview. thank you for the time stamps, they are super valuable when wanting to zero in on topics. i wish all interviewers did this. 2 Henriett Hadler Henriett Hadler 7 days ago (edited) Wow! I have been following David Sinclair for a while now, but this interview was the best. Thank you Shane (? - sorry if misspelled your name) for your questions. You two are a match made in heaven and please keep conversing and do more Q&As in the future. You asked questions that make us think in a broader sense what it means to have a longer life. The impacts on society, environments, etc. I hope you two had a good time- there seemed to be a real mutual respect and synergy that came through the screen. I keep following David Sinclair's works; share this interview with my teens so we can converse more about longevity. As a mum it's my responsibility to raise them well and good foundations for health is part of that. And I subscribe to this channel without even knowing what to expect- but oh boy I enjoyed this session so much, you sold me the rest of stuff you do. Thanks for both of you your time and work and thanks for your teams behind the scenes. Myrna alexander Myrna alexander 2 days ago I so enjoy your podcasts! Follow in my life and encourage my clients to do. I am psychotherapist and nutritionist. Jagan .Vaman Jagan .Vaman 9 days ago David is a humble and compassionate scientist...though his achievements are great. His personal traumatic experience with losing his mother shows his human side. I read his book lifespan...brilliant! I am on omad, metformin 2G, niacin, quercetin, veg diet no diary no alcohol 40 min walks....I feel great at 61!. I have never felt better even at 30! More power to you Dr David Sinclair! Medicine plus technology is going to revolutionize how we live longer and healthier.... 2 James James 17 hours ago (edited) this dude does not go very long without mentioning he is working on or discovered whatever he is saying is important Robert Kuiper Robert Kuiper 9 days ago Thank you David for the open heart and inspiration! Suzanna Dwyer Suzanna Dwyer 12 days ago It fascinates me that you and many others talking about longevity are young, 40's 50's t most. I am 80 and often wonder what you will be saying in 10 or 20 years. True I was fortunate to receive the longevity genes, I have brothers who are 84 and 85 and quite healthy too, but there must be other factors at work that you are not detecting. 9 Grant Burris Grant Burris 2 weeks ago David, I made my original comment when the talk was half over. Now that I have heard the entire episode, I want to stress again, how valuable this talk was. This was miles ahead of all the others. Thank you. 3 g b g b 9 days ago This interview was the best a watchbon the last time. It's blow my mind !! So much precius information. Absolutly excellent . 2 Judith Hatch Judith Hatch 5 hours ago actually I'm doing well with the one meal a day , just on my 4th day, but going well. Drink my coffee in morning, followed by water, hot non caffeine tea and water in afternoon. Getting off my butt every hour walk around trying to get 4000 steps a day and more on days off. Whole non processed plants, fruit, egg and fish, beans. 65yo will see how it goes. but can tell fluid retention down, less joint pain already. This is for long haul. As I age in years want quality of life while I'm here. Dr. Sinclair has tapped something in me to be motivated., thank you! shekatagani shekatagani 23 hours ago You don't need to go as long as 3 days for Major Health benefits, Eating one meal a day and eating whole foods, cutting Carbs and Sugar, limit Alcohol. Do this with a little exercise and you will be a very fit person. I am 67 and I've taken on this way of living and I'm more healthy now than I was 20 years ago. 1 FRITS FLAPOOR FRITS FLAPOOR 2 weeks ago I'm happy Sinclair admits his sleep habits are not optimal, its the same as me. Many nights i don't even sleep, i know it's bad, but this is reality. I worry too much and need to change it. But i never wear jackets, even not when its below minus 10°C and i am much younger looking than my brother and cousins who are bald grey already for years 1 Oman Oman 1 day ago This has really changed my opinion on the carnivore diet. Like steroids and drugs they make you feel good but it could have long term negatives. DEB WEST DEB WEST 13 days ago I have always slept few hours even though I never do caffeine. I began taking NMN in the morning and immediately felt a jolt like caffeine. Now I can not sleep longer than 4 hours. I want more sleep. 2 Matt j Matt j 3 weeks ago Excellent roundoff of some wonderful techniques Aaliyah Lee Aaliyah Lee 10 days ago Life expectancy is the average length of life of a group of individuals. The way to increase this is to get more individuals to live longer than the current average than die sooner. One way to do this is to persuade the members of the group to eat a healthy diet in moderation and to get regular exercise. I have been watching Dr. Sinclair's interview and bought his book “Why We Age and Why We Don’t Have To” very eye-opening and educative. In there, there's no point increasing lifespan without health span. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. I hate aging and the illnesses it brings over time. NMN Vitruvin Health is the most cost-effective brand for me. LaaneyChoonz LaaneyChoonz 2 weeks ago David Sinclair should write a Cookbook! Foods to live longer! 2 B R B R 11 days ago I love this guy...he literally is a gene...ious April Michael April Michael 4 days ago One of ny faves Mr Sinclair. You're one of very few docs I listen to whenever you upload new episodes. Cheese & wine ohhh my food. Noooo 🙆‍♀️🙆‍♀️😥 Creighton Freeman Creighton Freeman 10 days ago Regarding sleep, the Yogi Sadghuru says rest is essential, but distinguishes between rest and sleep. Most people do not know how to rest without sleeping though. I have noticed that when doing certain kinds of breath work, I need less sleep. 1 01maggie 01maggie 2 weeks ago My 98 year old Mom sleeps 12 hours every night. She was always napping when I was a little girl. She said even as a child she would sleep until noon on weekends. Friends would come to play and her mother said .. Florence is still sleeping... Maybe she has a lot of melatonin in her system??? By the way she will be 99 this October!! She had covid a few months ago and did well!! Actually better than me... I found the NMN and Transreservatol saved me from long covid. Wish I took it during the acute phase .. Also chaga mushroom..game changer...stops cytokine storm which happens with Covid!! Chaga also kills cancer!! 1 Jatinder Singh Jatinder Singh 12 days ago (edited) What are the tests available to see your health and age? You may live really long, time is changing. Thanks. Richard Middleton Richard Middleton 13 days ago Interesting about eating less protein increases life yet being strong with a good amount of lean muscle mass is also linked to increase life expectancy. I'm confused now! Is it simply animal protein that should be minimised? 2 Sebastian Niemann Sebastian Niemann 12 days ago great interview 🙏🖖❤️ Nikki Shevillo Nikki Shevillo 5 days ago Do you think NMN stimulates growth of cancer cells if ur prone to breast cancer since it promotes dna, cells, etc? Thx!! 1 Ankush Sharma Ankush Sharma 3 weeks ago Bring more people like him..nothing brave in accepting death¡ 1 Esther Jaedi Esther Jaedi 13 days ago Iv now listed to several podcasts like this to living your best health with longevity in mind. However, all you scientist drs do mention in your videos that a good protein diet, resistance exercising, good sleep, meditate, de stressing and positive attitudes contribute to this. What I’m still confused about is that one Dr says that the carnivore diets supersede the plant protein diets. Tho Dr Sinclair discourages carnivore as not good at all for longevity. Why is this so controversial. Thank you. Great interview Mohib Quadri Mohib Quadri 3 weeks ago Great One ⭐ 1 Agapanthah Agapanthah 12 days ago Great job...subscribed Trader-X Trader-X Trader-X Trader-X 11 days ago Should add PTX THERAPY to Exercise Regiment- Posture, Gate, Muscle Balance, Range Of Movement, Function & Performance 1 Joseph Whittle Joseph Whittle 2 weeks ago David, please tell us about linoleic acid and how to lower our exposure. FreeMocean FreeMocean 9 days ago He looks more sickly everytime I see him. Totally invalidates the point of a PHD if he ignores the big things like bioavailability of protein sources, quality of fat soluble vitamins and fatty acids while ignoring oxalates phytates and lectins in plant foods. I will easily outlive this well meaning fool, but not before his terrible advice ruins tens of thousands of lives. 1 G SOUNDRA PANDIAN G SOUNDRA PANDIAN 2 weeks ago Prof.Sinclair, please do not fast too much as you will become thin. Your face muscles seem to be reduced, not appearing tight but appear to be slightly hanging that will soon make you to appear older. The face of the interviewer is looking much healthier than yours. We must find an antiaging solution by eating 3 times food per day with out any fasting. 01maggie 01maggie 2 weeks ago Does David Sinclair have a new book coming?? Lilian Lilian Lilian Lilian 2 weeks ago For longevity: maintain muscle strength by exercise and getting the required and essential amino acids. The easiest and most bang for your buck is eating meat, optimally not factory raised. 3 Myrslokstok Myrslokstok 6 days ago (edited) I think his cookie 🍪 jar 🏺 is empty by now. He looks even younger now and in 720p. HORNGEN4 HORNGEN4 2 days ago David seems to contradict himself a lot, and while he says he only discusses literature, there's a lot of quasi-science sounding statements. I don't trust him. amma Braun amma Braun 2 weeks ago Thank you Valart VALERIE HOPE BENNETT Valart VALERIE HOPE BENNETT 2 weeks ago THANKS GREAT Git Gen Git Gen 3 weeks ago What to eat, eat to eat, just don't over do it. Abhi Patil Abhi Patil 2 weeks ago Too good CA M CA M 2 weeks ago How to not die... Move to another planet baby 'cause this one is goin' down. 4 Not Artic Not Artic 7 hours ago Every day is a 🎁 Best Of Best Of 4 days ago My 15 year olds remember dvds!! Izulka Buroszek Izulka Buroszek 11 days ago Where from obtain healthy fish? and plants which are available contain little or no nutrients nowadays. It is impossible to think that Okinawa diet is longevity unless you look at other aspects of these people's lives. They do not sit 8hrs in an office, or spend 4hr in a car. 1 Manea Loredana Manea Loredana 3 days ago Not me watching this at minute 49 with my brown resveratrol pill in my hand 🫤🫤🫤👀👀👀 B Reft B Reft 11 days ago To be "productive" for one more year will save money for who, exactly? 1 J R J R 2 days ago oh boy he's looking older Myrslokstok Myrslokstok 6 days ago Well you are going to log in your data to the hospital, but they will not look at it, there AI will go trough it all. Steve De Santolo Steve De Santolo 7 days ago 288K backlog for Tally Health :) atisha gupta atisha gupta 2 weeks ago What is the Mediterranean diet? Jordon Jordon 10 days ago Why are people acting like that "in 18 months" comment wasn't actually crazy exciting? ABC XYZ ABC XYZ 23 hours ago First, Faith 2nd, Family 3rd, Finance 4th, Flight [Rapture of Born-again Believers] !!!!! BRECKDOG Hello BRECKDOG Hello 2 weeks ago His claims eg on Resveretrol and NMN get debunked for humans. Has all the answers - if you're a mouse ! 2 Samirkumar Gupta Samirkumar Gupta 2 weeks ago What is wrong with David Sinclair's left eye, seems to be shrinked 3 Eszter Horvath Eszter Horvath 17 hours ago Big liar, only to get financed Sharique Ahmad Azizy Sharique Ahmad Azizy 3 weeks ago 5:00 Kenneth Marquis Kenneth Marquis 2 weeks ago Mediterranian kess neat etc. Andre Dias Andre Dias 13 days ago Well, interestingly, Sinclair doesn't look very healthy. His skin doesn't glow, he seems weak, it really feels like he doesn't have a lot of testosterone... So what the point to live longer like that? 1 Zeb Zeb 7 days ago Hi David Sinclair, there is a way to not die. It is by believing that Jesus died on the cross to pay for our sins, and rose on the third day. Repent, for the Kingdom of Heaven is at Hand! God Bless 1