The longevity sirtuin – what you need to know about SIRT6 19,240 views Jun 18, 2021

#longevity #science #latestresearch The longevity sirtuin – what you need to know about SIRT6 19,240 viewsJun 18, 2021 The Sheekey Science Show 26.8K subscribers SPONSOR: Longevity.Technology - https://www.longevity.technology/?utm... Sirtuins are highly conserved proteins that are involved in a variety of important cellular processes such as DNA repair, metabolism and circadian rhythms. The mammalian sirtuins (SIRT1-7) are a family of proteins that carry out NAD+-dependent protein deacylation and mono-ADP-ribosylation. These modifications on proteins can influence their stability, localisation within a cell and activity. In the late 90s interest in sirtuins bloomed as it was found yeast lived 30% longer when they had an additional copy of a yeast sirtuin, Sir2. Similar studies have now been performed in mice, but whilst overexpression of SIRT1 in mice does not result in lifespan extension, overexpression of SIRT6 does. This has led to SIRT6 being referred to as the longevity sirtuin. However, there seems to be some sex- and mouse strain-dependent differences. So, in the remainder of the video, we will discuss what you need to know about SIRT6 including it's proposed cellular activities, it's association with longevity and how SIRT6 activation using allosteric activators could have future therapeutic potential. TIMESTAMPS: Intro - 00:00 Sirtuins - 00:45 SIRT1, SIRT6 and longevity - 03:00 SIRT6 and DNA damage - 08:30 Activating SIRT6 - 09:50 Additional thoughts - 11:45 #longevity #science #latestresearch #TSSS REFERENCES: Roichman, A., Elhanati, S., Aon, M.A. et al. Restoration of energy homeostasis by SIRT6 extends healthy lifespan. Nat Commun 12, 3208 (2021). https://doi.org/10.1038/s41467-021-23... Regulation of SIRT6 protein levels by nutrient availability - https://doi.org/10.1016/j.febslet.200... Regulation of SIRT1 protein levels by nutrient availability - https://doi.org/10.1016/j.febslet.200... Kanfi, Y., Naiman, S., Amir, G. et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature 483, 218–221 (2012). https://doi.org/10.1038/nature10815 Sirtuin activators and inhibitors: Promises, achievements, and challenges - https://doi.org/10.1016/j.pharmthera.... SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species - https://doi.org/10.1016/j.cell.2019.0... Huang, Z., Zhao, J., Deng, W. et al. Identification of a cellularly active SIRT6 allosteric activator. Nat Chem Biol 14, 1118–1126 (2018). https://doi.org/10.1038/s41589-018-01... Check out @LifeXtenShow latest video - https://www.youtube.com/watch?v=q03Cu... Icons in intro; "https://www.freepik.com/free-photos-v... "Background vector created by freepik - www.freepik.com Chapters Intro 0:00 Sirtuins 0:45 SIRT1, SIRT6 and longevity 3:00 SIRT6 and DNA damage 8:30 Activating SIRT6 9:50 Additional thoughts 11:45 112 Comments rongmaw lin Add a comment... The Sheekey Science Show Pinned by The Sheekey Science Show The Sheekey Science Show 11 months ago So is SIRT6 my new favourite protein? Hmmm, of course not, p53 all the way, but it's up there, maybe top 10 :D 37 Brent Nally Brent Nally 11 months ago Awesome video as always! I’m currently taking fucoidan, quercetin, and fisetin daily because I think there’s good evidence these molecules extend healthy human lifespan at proper doses and it turns out there’s pretty good evidence that all 3 may be SIRT6 activators which would partially explain why they can extend healthy human lifespan. 24 Paul Kabrna Paul Kabrna 11 months ago Another great video. If you take a Sirt6 activator, is it essential that your NAD+ levels are at a 'healthy' level to make the effort worthwhile? 7 Maria Kierstead Maria Kierstead 3 months ago This was an excellent video and very much appreciated! Thanks! Would you say Sirt6 is a senolytic or is Sirt6 under expression a marker of cellular senescence? Daxton Brown Daxton Brown 11 months ago You need to put all your video talks into a book. You have an incredible future ahead. 18 The Sheekey Science Show Little Voice Little Voice 11 months ago Have you thought about looking at bloodresult variations and aging? E.g markers of inflammation, blood urea, WBC, RBC etc and their changes over time. How they indicate internal aging and what we can do about it? BrandonFlorida BrandonFlorida 1 month ago Thank you for doing this. This is very superior to most YouTube discussions of longevity. ÆRO ŠPECIALIST ÆRO ŠPECIALIST 7 months ago This is genius. The influence on DNA to affect anti-aging is fascinating. ❤️ This is going to make a lot of people wealthy. ArticBlueFox96 ArticBlueFox96 11 months ago Amazing and informative, as usual 3 The Sheekey Science Show Kamanashis Roy Kamanashis Roy 10 months ago (edited) The difference between the lifespan extension in male and female mice study, indicates that lifespan increase may have been caused by igf1 reduction instead of sirtuin-6 itself. 6 Acoustic Motorbike Acoustic Motorbike 1 month ago Thankyou so much. Really useful explanation. Which natural compounds activate Sirtuin 6? Luis Martínez Luis Martínez 3 months ago Very dynamic and graphic video! Thank you so much :) BrandonFlorida BrandonFlorida 3 months ago Since DR (or CR) are said to function by activating Sirtuin genes, does that mean that female test subjects respond less to DR than males? Also, at the present time, is it believed that resveratrol has any health benefits at all? Tom Funk Tom Funk 11 months ago In being tied to CR, I wonder how IF (including in different patterns / durations) would affect SIRT6 activation.... possibly coupled with various 'supplements' (e.g. NAD precursors). How easy is it to measure levels of SIRT6? 1 The Sheekey Science Show birage birage 11 months ago What's the story with fucoidan as a sirt 6 activator? 21 Harris Ward Harris Ward 4 months ago Is it possible to activate fisetin, quercetin and fucoiden with piperine like resveratrol supposedly is? Are there any other activators you would recommend to increase the efficacy and bio availability of these supplements? Thanks! Galileo Galilei Galileo Galilei 5 months ago (edited) Great video…love it when you go “bio-chemical”!….no apologies needed…. The Sheekey Science Show Emil Aslan Emil Aslan 7 months ago You can activate sirtuin 6 with cyanidin which is found in red cabbage and cherries. 2 Pharmnivore Pharmnivore 11 months ago Have you read anything about Fucoidan as a SIRT6 activator? 4 Mark Whittaker Mark Whittaker 11 months ago You are totally my hero! 6 The Sheekey Science Show Cat Man Cat Man 10 months ago Question: Being from mixed parents...could one parents genes be latent and could NMN bring them out of latency? I'm asking because of incredible results I'm getting nfrom NMN incuding white hair regaining colour which starts off the same colour as my mums hair, hazel, where mine was always really dark brown. Rhyothemis princeps Rhyothemis princeps 11 months ago I have wondered about something for a long time - - butyrate is a general HDAC inhibitor; sirtuins are HDACs. What's up with that? 1 marco nuñez marco nuñez 11 months ago thanks for all this interesting information The Sheekey Science Show Peter Vafeades Peter Vafeades 2 days ago What about Urolithin A and Fucoidan as SiRT6 activators? BrandonSLockey BrandonSLockey 11 months ago longevity technology is the perfect procrastination website for me xd 8 The Sheekey Science Show Christopher Ellis Christopher Ellis 4 months ago So, like a set of spanners, each for a certain sized bolt. 🔧🔧🔧 R3d Gh Ok R3d Gh Ok 11 months ago How did you learn to draw like that? Is your job related to it? The Sheekey Science Show Goccia Goccia 11 months ago Can u make video about that new study saying Ageing process is unstoppable ?? want to know whats your take on that. The Sheekey Science Show Zulkifli Curran Zulkifli Curran 11 months ago Could you tell us which supplements activates Sirtuin 6? 3 Jonathan Jonathan 9 months ago very good video on sirts The Sheekey Science Show Tony Castani Tony Castani 11 months ago Why haven't researchers done an in-vivo, randomized, placebo controlled study of fucoidan plus an NAD precursor looking at synergistic longevity benefits? Fact Checker Fact Checker 8 months ago I would suggest giving more credit to the lab groups, authors, institutions, and journals. These studies are often progressions of earlier studies by the same labs and principal researchers and not one off studies. It's not that hard to give credit where it's due. Tristen James Tristen James 10 months ago for those of us with hearing deficits the voice used in these videos is not conducive hearing the material accurately regardless of how informative the presentation. gjpcmd1 gjpcmd1 11 months ago Are there any Sirt6 activators currently commercially available 1 frank brown frank brown 8 months ago i have L-Ornithine Alpha ketogluterate. norelon norelon 11 months ago Can you eat something to further activate SIRT6? 3 Lars Nyström Lars Nyström 2 months ago Do you have a bad microphone? It's too pa8nful for me to try to listen to your videos. I think I would like them if the audio was better. John Vercellone John Vercellone 11 months ago Dr.Cheekey is an alien obviously with that intelligence.