Rhonda on : diet and lifestyle regulate longevity with Dr. Valter Longo about fasting and diet in longevity bout Jul 9, 2018

1:56 / 1:06:10 • Defining fasting Dr. Valter Longo and Dr. Rhonda Patrick 348,078 viewsJul 9, 2018 FoundMyFitness 425K subscribers This episode is a spectacular round two podcast with Dr. Valter Longo. Dr. Longo is the current director of the longevity institute at the University of Southern California and also director of the Oncology and Longevity Program at the Institute of Molecular Oncology Foundation in Milan, Italy. Dr. Longo’s research focuses understanding the biological mechanisms that regulate the aging process, the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human age-related diseases, including those of autoimmune origin and cancer. ▶︎ Get the show notes and transcript! https://www.foundmyfitness.com/episod... Chapters 00:00:00 - Introduction 00:01:00 - Defining fasting 00:04:48 - Caloric restriction in monkeys 00:06:40 - IGF-1 & mTOR 00:11:48 - Laron's syndrome 00:14:20 - Fasting in other species 00:21:25 - Cancer 00:30:44 - Fasting-mimicking diet 00:38:57 - "Yo-yo" diet 00:42:49 - Muscle mass 00:47:33 - Apoptosis 00:53:04 - Refeeding 00:56:02 - Biomarkers for health ▶︎ Follow Dr. Longo on Facebook: http://www.facebook.com/profvalterlongo ▶︎ Visit ProLon FMD: http://www.prolonfmd.com/ ▶︎ Dr. Longo's book "The Longevity Diet" https://amzn.to/2zvxz8n Links related to FoundMyFitness: ▶︎ Subscribe on YouTube: http://youtube.com/user/FoundMyFitnes... ▶︎ Join my weekly email newsletter: http://www.foundmyfitness.com/?sendme... ▶︎ Crowdfund more videos: http://www.patreon.com/foundmyfitness ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/fo... ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness Chapters Introduction 0:00 Defining fasting 1:00 Caloric restriction in monkeys 4:48 IGF-1 & mTOR 6:40 Laron's syndrome 11:48 Fasting in other species 14:20 Featured playlist 51 videos Interviews FoundMyFitness 598 Comments rongmaw lin Add a comment... someDoodz someDoodz 3 years ago Another fantastic interview from Rhonda Patrick. Highly recommended. The additional explanatory comments during the video are very helpful. Thank you Rhonda and Valter, your work is extremely important. The genuine unbiased search for underlying metabolic mechanisms is palpable in this interview and much appreciated in a world where this type of truthful attention to detail is rare. 64 FoundMyFitness Methodtraining Methodtraining 3 years ago Thank you for having Valter on your show once again. This great Scientists information literally saved my life. My biomarkers ( blood pressure/cholesterol levels/etc) were absolutely out of control until I started doing his fasting mimicking diet and following diet advice. My doctor has called the change a “miracle.” 63 FoundMyFitness FoundMyFitness FoundMyFitness 3 years ago (edited) Hey, guys! As usual, this episode has amazing show notes and transcript available at the website at foundmyfitness.com/episodes/valter-longo-2 . A huge thanks to Dr. Valter Longo for coming on the podcast a second time! If you enjoy these episodes, you might be a nerd. Or, put another way, you're our kind of people! So why not support what you love and become a member of the community? Learn more about how you can setup a pay-what-you-can monthly supporting membership at foundmyfitness.com/crowdsponsor . In this episode, we discuss... • 00:01:00 - The problems with using non-specific terms like “intermittent fasting” and a general exploration of what each of the terms that describe types of dietary restriction means, whether we’re talking about intermittent fasting, caloric restriction, time-restricted eating or periodic prolonged fasting. The latter of which is a special focus of Dr. Longo. • 00:04:11 - What two seminal studies on chronic caloric restriction in primates from the 80s teach us about caloric restriction as a preventer of age-related disease, and how the effects of caloric restriction may actually be stronger when the diet that is being restricted is an unhealthy one – similar, in some ways, to the typical western diet. • 00:07:34 - How the shift between normal metabolism and what Dr. Longo refers to ketogenic mode is subject to individual variation and the type of restriction practiced. Of particular importance is the protein or essential amino acid consumption. • 00:08:06 - How the suppression of the IGF-1 pathway, typically a hallmark of prolonged fasting and caloric restriction studies and potentially needed for some of the benefits, may fail to be achieved in human caloric restricters that eat too much protein. • 00:09:34 - How certain macronutrients influence the insulin/IGF-1/growth hormone axis interact to modulate aging in many cell types. • 00:10:43 - How mice and humans who have growth hormone receptor deficiencies have low circulating IGF-1 – as little as 10% of normal levels – and have reduced risk of diseases like cancer, diabetes, and age-related cognitive decline, hinting at what future research might reveal about the beneficial effects of prolonged fasting and fasting-mimicking diets through the downstream effects of periodic deprival of growth-related factors. • 00:11:05 - How the growth hormone / IGF-1 axis got a big boost early on in scientific interest when it was revealed that mice that have either deficiency in growth hormone itself or the growth hormone receptor live up to 40% longer and how this is accomplished through what is essentially a delaying of the decrepitudes of old age. • 00:13:42 - The clever experiment design where human epithelial cells were incubated either in serum taken from controls or the serum taken from growth hormone receptor-deficient Laron’s patients showed that the reduction in growth factors ultimately lead to the cells manifesting qualities of cancer resistance, like fewer DNA breaks but an increase in cell death, which is also an important protection against cancer known as apoptosis. • 00:15:02 - The origins of what Dr. Longo calls the fasting-mimicking diet – a 5-day diet focused on recapitulating some of the benefits of prolonged fasting, like dramatic changes in metabolic biomarkers, but without some of the drawbacks like reduced compliance and other risks that can come with multiple days of grueling strict water fasting in large, heterogeneous populations. • 00:15:42 - How periodic prolonged fasting or the fasting-mimicking diet may be able to render cancer cells more vulnerable while conferring stress resistance to healthy cells, a quality known as differential stress resistance. This can happen because of the way fasting interferes with what is known as oncogenic signaling. Also refer to 00:25:22. • 00:21:41 - The mixed results associated with the use of the ketogenic diet in treatment of cancer and how some cancers seem to be hurt by the metabolic switch of utilizing ketone bodies, which creates oxidative stress from the use of mitochondria, while other cancers seem to be able to use ketones effectively as an energy source, potentially accelerating their growth. • 00:22:54 - Some of the early but promising pre-trial clinical anecdata suggesting potential complementary roles for the ketogenic diet and the fasting-mimicking diet (FMD) used in conjunction with conventional treatments like chemotherapy or radiotherapy for certain cancers like gliomas. • 00:28:05 - How oncologists might approach incorporating the fasting-mimicking diet, which is still seeking further clinical validation and approval, into their patients’ care (if they choose to). • 00:30:44 - In the context of aging, how the fasting mimicking diet has been shown to “reset” metabolism, driving down biomarkers associated with poor metabolic health, inflammation, and cardiovascular health. • 00:31:45 - How, in contrast to chronic caloric restriction, the fasting-mimicking diet seems to normalize biomarkers like blood pressure and fasting glucose rather than continuing to drive them down into ranges lower than might be considered healthy. • 00:34:09 - The prospect of using emerging ways of measuring aging objectively, such as through DNA methylation profiles, to tell whether or not an intervention like fasting is having an effect on aging as a whole. • 00:35:14 - How long the metabolic effects of the fasting-mimicking diet tend to stick around and how often Dr. Longo thinks the fasting-mimicking diet should be done for most people and what sort of factors influence that. • 00:38:33 - The fasting-mimicking diet as a boon for the psychology of weight loss where, due to its cyclical nature, adherents can enjoy potential benefits like the reduction of harmful fat known as visceral fat while sparing subcutaneous fat and lean mass, without completely overhauling all other areas of their life the rest of the time. • 00:40:09 - How the fasting-mimicking diet, due to the shortness of the interval, seems to avoid the deleterious and generally undesirable effect of slowing the metabolism down in the way so-called yo-yo diets seem to. • 00:44:24 - How fasting, through the shrinking and then re-expansion of whole systems like the liver, kidneys, heart, and immune cells may represent a type of whole-system renewal that originated as a three-billion-year-old self-repair mode that was only activated during periods of famine or inconsistent food availability, but might now be dormant in people living in a modern world of regular food intake. • 00:45:39 - How Dr. Longo’s group has shown that, in animal models of multiple sclerosis and pharmacologically-induced type 1 diabetes, several cycles of the fasting-mimicking diet is able to reverse disease and restore healthful function. This mechanism also may generalize to erasing other diseases of autoimmunity through the destruction of autoimmune immune cells that are essentially reset through fresh differentiation from progenitors untainted by autoimmunity. A very exciting area of continued inquiry! • 00:46:17 - How shorter fasts may fail to approach some of the effects of periodic fasting and the fasting-mimicking diet by failing to achieve adequate glycogen depletion and ketogenesis. • 00:53:04 - How clinical trials demonstrated that the effects of IGF-1 are probably context dependent, exhibiting a sort of “Goldilocks principle,” in which too much IGF-1 promotes cancer, but too little (as in the case of chronic, long-term caloric restriction) negatively affects the immune system. But the refeeding that follows fasting mimicking creates an environment that may be just right: it switches on IGF-1, promoting the regeneration of healthy cells, even restoring full organ systems. • 00:55:05 - The importance of adequate protein during the refeeding phase following prolonged fasting or the fasting-mimicking to promote proper growth signaling to restore systems that have been broken down. • 00:56:01 - Dr. Longo’s “top picks” for assessing biological age – markers a person can ask their doctor to measure to gauge how well they’re aging. • 00:59:05 - A sneak peek at what’s covered in Dr. Longo’s new book, The Longevity Diet. https://amzn.to/2zvxz8n 67 Chris Bigelow Chris Bigelow 3 years ago Awesome content! I love that you include the citations as real time overlays so the audience can follow along while you discuss the data. 9 TheBoydbeauford TheBoydbeauford 3 years ago This is fantastic. I've long been interested in Dr Longo's work. So awesome to have the current state of research on fasting & disease control summarized so clearly, & without unsubstantiated claims. The linked quoted papers are a great & useful resource in addition to the discussion. Thanks Rhonda. 2 Kevin Street Kevin Street 3 years ago Thank you for doing this fascinating interview! I'm really intrigued by what Dr. Longo said about how occasional fasting may activate a sort of self-repair mode for the body - and why we don't automatically fast when the body is damaged like we automatically get tired when we don't sleep. 5 Victoria P Victoria P 1 year ago (edited) Beautiful interview , substantial ! How low carb-high fat diet can be a challenge and it is so easy to fast with it. I have been on low carb, moderate amount protein, high fat for the last 3 and the half years. On IF for the last 2 and the half years, i eat 2 times a day and often i do one meal in 24 hrs. Could not be easier, tasty! Never feel hungry, do mot have to count calories really, i know it is lower than if i would be on high carb diet. I do not use sweetener for the last 2 years, we all love foods but your taste receptors change. Of coz in therapeutic ketosis you need to measure ketones against glucose 6 Heather Milnes Heather Milnes 3 years ago This is such important information for all of us. Thank you so much for posting this and to the two doctors in the discussion. 2 FoundMyFitness brian warner brian warner 2 weeks ago Fabulous interview! I’ve been a huge fan of both Valter and Rhonda for 6 years since Valter’work on mice with MS Casiana Feliz Casiana Feliz 3 years ago Rhonda you are the best! been waiting for your return. thanknyou for bringing this topic to the cientific pop table. thank you for doing this for us normal people who dont have acces/ knowledge to grasp the meaning of these studies, becomes loud and clear through your interviews and interviewed 2 FoundMyFitness POV Cycling Strolls POV Cycling Strolls 3 years ago I have a theory on why the organs shrink while fasting. The body tries to save calories so it will shrink the organs for a lower calorie expenditure. Thanks for the podcast I am as we speak in a 36 hour water fast. Aiming for 5 days or more 2 Kyle Harvey Kyle Harvey 3 years ago I have never seen a better informed, intelligent interviewer. All i can say is wow! So informative without being redundant. 13 Jillian Pumphrey Jillian Pumphrey 1 year ago Just discovered Dr. Longo about a month ago I love his studies and what he talks about and started listening to his audio book today love this information thank you! tripp tripp 3 years ago Dr patrick, I'm a huge fan of your show, I really like how you put the scientific papers on the screen while he's talking about them. Makes it more informative and interesting 3 Lucia Samaras Lucia Samaras 3 years ago These interviews are exemplary! They push my non-clinical mind to integrate science in a manner that rewards my curiosity with very practical application from well-researched investigation. You guys are the new Carl Sagans - thank you! 4 Ted Rinshed Ted Rinshed 3 years ago (edited) Thanks to Rhonda, I'm now in my 2nd week of intermittent fasting (14/10). I feel great and have lost about 5 pounds and 1% BF. I feel like a teenager again in the mornings during the last few hours of my fast. I was super skinny and skipped a lot of meals when in High School. I also have good energy to do my morning runs before eating around 10:30 am. Hopefully, the cells in my body are benefitting as well as I feel 11 Craig Burkhart Craig Burkhart 3 years ago Glad you are back, you should do an entire podcast on health during pregnancy. My wife would be very grateful :) 12 Julio Retana Julio Retana 3 years ago Hi, Great video! Love your content. I was wondering if you could make a video on special nutrition for pregnancy and what does the latest science say. Thank you! michael onello michael onello 3 years ago BRILLIANT....! Thx to both of you.. I can only imagine where science will take us over the next ten years.... 2 Viewing Viewing 3 years ago Good timing on the video, Fasting for around 40 days with your methods, lost 25 pounds of fat which i did not know i had and gained lean muscle, I have to say thank you very much for these methods and diets. This is the best channel for all men and women, please promote your brand into bodybuilding so that the people who typically get misled gets a chance to see your content! 9 Bill Hooper Bill Hooper 3 years ago Excited to find out about The Longevity Diet thank you both for all your hard work. 2 Farooq S Farooq S 3 years ago Thank both of u bringing this valuable information for people who are suffering.. 1 India Bliss India Bliss 2 years ago Thank you so much for this. The once a month 3-5 day fast is definitely the way forward for me. 4 Nils from Alaska Nils from Alaska 3 years ago (edited) Dr. Longo mentions in this video that there's a food aversion problem among cancer patients (the patients come to associate the FMD with their chemotherapy, and are averse to eating the same foods again the next time they go in for chemo). As a result, he's developed several variations on the FMD. I hope he'll make those variations public at some point, if only through ProLon. (i.e., there could be several different ProLon kits, all of which provide the necessary macros). This would allow people who want to try the ProLong five day diet, to choose one that contains food they like better and/or aren't allergic to. Case in point: I've done several five day water fasts, and have thought about ordering the ProLong diet to see how it compares with water fasting. I haven't done so because I'm allergic to wheat and nuts, two items which are present in the FMD. A nut-free, grain-free version would make it possible for folks with allergies like mine, to try it. (I've also tried creating my own grain-free, nut-free version following the FMD's macros, but a packaged diet would be easier) 3 FoundMyFitness Megan Hensley Megan Hensley 3 years ago Keep these videos coming! It is helping empower me to educate myself and put me in control of my health. Thank you! almostmatt1 almostmatt1 3 years ago How timely, I just ordered Dr. Longo's book. Thank you Dr. Patrick!! :) 4 windu80 windu80 2 years ago Dr. Rhonda Patrick, it would be very interesting to hear your thoughts about PMGs (Protomorphogens) and its effects on autoimmune conditions. I just discovered that one, but not sure what to think of it... 1 Pyriphlegeton Pyriphlegeton 3 years ago I'm very happy to see one your interviews again. I hope you had and have a wonderful time with your child. :) 24 mfahlers mfahlers 3 years ago This is perhaps the most interesting interviews of the many i have viewed of Dr. Longo. I reproduced the exact combination of fats, proteins, and carbohydrates of the the Prolon diet (for less than $1.50 per day), and extended it to 6 days. I also decreased the calories for days 2 through 6 to 550, in order to ensure positive effects. Five days later during my yearly health screening at work my glucose level was 73, 16 points lower than the past 4 years. This change occurred even though I had eaten a plant based diet (with no processed food) for more than a decade. 11 francis bertolini francis bertolini 3 years ago I want to go back to school and learn this. I'm in health care and I agree that Alopathic medicine has reached a wall in relation to treating chronic disease 1 Sonia Roman Sonia Roman 3 years ago I am in round two of the fasting mimicking diet. It is hard, but worth it. Stuart Tanner Stuart Tanner 3 years ago Dear Dr. Rhonda can you please make a video on how to properly grow broccoli sprouts from start to finish, also including the best way to freeze/store them and then also how to cook them or when to eat them raw? That would be very helpful. Many people seem to not know the correct way to do this properly. Thank you. I hope you're well. x 2 james hancock james hancock 3 years ago Great interview - Do you know how much NAC or Resveratrol it takes to replicate Rapamycin in terms of mTOR inhibition ? and if one was successful how long does a cycle last for, is this known/can it be measured ? 2 Pedro Carr Pedro Carr 1 year ago Thank you Rhonda for this excelent and nurturing interview with Valter! I've got a doubt thou, during the 5 day fasting period is it recomended yo workout? You see, I workout (resistance, weights) every weekday un the morning, should I stop working out during this period or is it recommended to continue to do so? Another question is, what can we drink during this period besides water. Can we drink green tea and coffee? Any other suggestions for drinks during the fasting period? 1 Jake Stevanja Jake Stevanja 3 years ago incredible quality video with the studies and citation edited, really made it amazing!!! what program was used to achieve this? 1 Maria K Maria K 3 years ago Thank you for this wonderful interview. 1 B Szlado B Szlado 2 years ago Thanks for the great interview! I wonder though about his argument against the Ketogenic diet (ie not followed by long living people in the past) - as he just says how the body is better aligned to fasting (ie. using fat and ketones as fuel) rather then eating all the time (and burning sugar mostly)... Maybe 'ketogenic diet' has been followed for thousands of years before the agriculture developed... Many of the centenarians have the right genes, instead of having a great diet/lifestyle... . 1 Bill Vogel Bill Vogel 1 month ago I fasted the day before each chemo treatment for 6 months 5 years ago. I have Leukemia and Non Hodgkins Lymphoma . I had 15 visible tumors in my neck to start with. One week after my first chemo treatment I had an exam and all of the tumors were not visible any more. The oncologist had never seen results like that before and I told him I fasted 24 hours before treatment. His response? Oh that's interesting and left it there. UNREAL! This is our current medical system for you. Nothing innovative or new except the latest chemo drug. They treat patients the way they learned in medical school many years before. Very sad. Cesar Celis Cesar Celis 3 years ago Very good video with lot of good information. Thank you! 1 Riccardo Secci Riccardo Secci 3 years ago I love your podcasts 🙂 2 Matthew Lake Matthew Lake 3 years ago (edited) I've been doing calorie restriction for 15 years, but a few years ago I lowered my protein intake a lot. I was fine at first, but I'm sure it was affecting me in a negative way. I wondered if my IGF-1 dropped too low. I increased my protein a little and feel better now. And wrt to the monkey studies, there were just too many flaws in the way the studies were designed, and the NIA monkeys were actually restricted by 10% and in some cases, caloric difference dwindled to almost nothing at certain points of the study. Although it was interesting to see quite a few of the CR monkeys in the NIA study break longevity records (old-onset CR). With Sherman (age 43) being the oldest rhesus monkey ever recorded. There was also another small monkey study result that was published recently showing that CR worked very well with a 50% increase in lifespan. "Median survival for CR – 9.6 years Median survival for Control – 6.4 years" Many of the CR monkeys in this study also lived beyond the max lifespan for the species. https://www.nature.com/articles/s42003-018-0024-8/figures/1 7 Ben Nguyen Ben Nguyen 3 years ago Regarding the difference between the FMD and Intermittent Fasting/Feeding (as described by Dr. Satchin Panda).. after how many hours of fasting (ex. 15:8 or 23:1) would there be adverse health effects like those mentioned in Dr. Longo's interview on the HIH podcast (gallstones, overall mortality, etc (30m12s mark))? Also, any theories as to why daily fasting would cause such issues? In the future, what might a fasting diet look like for cancer patients? 24-48 hours of fasting pre-chemotherapy, followed by a normal re-feeding immediately afterwards with a standard diet (50% Carbs, 25% protein, 25% fat)? keto diet (80% fat, 20% protein, 10% carbs)? Also, didn't see any notes for it.. is this the link to the research by Morgan Levine (and others) mentioned at the 57m52s mark? https://www.biorxiv.org/content/early/2018/07/05/363291 Is there any plans to make the $300 5-day ProLon boxed meals (800 calorie a day) more affordable for the general public, or is it the intended market hospitals and oncologist professionals? 2 Mercury1955 Mercury1955 3 years ago Thanks for another video Dr Rhonda. I love them all. 1 brian warner brian warner 12 days ago Question if I may?; Since atophagy , for all practical purpose's is "not measureable", can we say with certainty that it "tops out" or levels off at any particular time when fasting (3 day? 5day? more?) Thanks for all the incredible interviews! Rhonda's knowledge, insights and ability to "pace" the interviews put her among the very best! I've followed Valter closely for 5-6 years since reading about his work with mice with EAE; he is a true visionary who, after not being taken seriously for so long by the so called "experts" and KOL's, is begrudgingly making believers of his critics because the results of his studies show long term fasting is so obviously an incredibly powerful healing modality with mind-blowing potential! A true "Rock Star" Thanks again! Dave McClure Dave McClure 3 years ago Q: how often should you do extended fasting / FMD to maintain health benefits? @35:50 "once every 4 months" (if you're in good health / good shape) @38:06 "monthly if you're obese / have other risk factors" seems like the general advice should be to do extended 3-5 day fast 1x/month until you get into shape / "good health" and then quarterly thereafter. (also wasn't exactly clear how long the fasting needs to be, altho seems like 3 days minimum to activate autophagy; certainly ok after 5 days) 145 FoundMyFitness Marc Richards Marc Richards 3 years ago Excellent! It just struck me that Dr. Longo is an example of nominative determinism. Haha. 6 Love Of inquiry Love Of inquiry 1 year ago Great video. I think Dr. Largo is working on some water fasting studies with Dr Alan Goldhammer. I would love to see you interview Dr Alan Goldhammer as well or even have them both on together.💗 2 Brendan C. Brendan C. 3 years ago I can’t wait for Rhonda’s talk with David Sinclair. I’d love to get a round table with her + Longo + Sinclair. 12 Shana Abell Shana Abell 3 years ago Have you thought about putting simplified bullet points in the drop bar, or giving a simplified breakdown at the end of these videos? I research nutrition more than the average bear, as well as other scientific topics and I haven’t been able to understand a good amount of any of these types of interviews. It would be nice if you could help those of us who don’t know certain language and certain assumptions of knowledge we may not have. I run my own business and simply don’t have time to research enough of all these interviews to fully understand what’s going on. This is why I love Joe Rogan interviewing you, he breaks things down for us. I’d love it if you’d consider this, I’d gain a lot more from your videos and I suspect others may too. Thx! I donate to you via your webpage because I appreciate you! 2 incapaisa incapaisa 3 years ago So the sweet spot for optimal health is pro long 5 day fast? Great Interview and hope one day you can have Dr. Jason Fung as a guest... Thank you Rhonda 50 Diane Tonacia Diane Tonacia 1 year ago I love the way she interviews 2 Matt Donaldson Matt Donaldson 2 years ago Loved this! Will buy his book kari25nov kari25nov 1 year ago Excellent! I just recommended Dr Valter Longo to the Nobel Institute ie as a candidate for The Nobel Price of Medicine 1 hermione00801 hermione00801 2 days ago (edited) Best way to judge if these people practice what they preach is how good and young they look and both Rhonda and Valter look amazing. MaceFXE MaceFXE 3 years ago Dr. Patrick - I have been doing every other day 24 hour fasting for a couple of weeks now and want to thank you for putting this information out. It has been the ONLY thing that helps me with weight loss. I've got several issues going on - heavy menstrual cycle and iron deficiency as well as hypothyroidism now. I am severely allergic to Fish AND Shellfish. I have an allergy to "man-made" iodine since it's mostly derived from the sea. Doctors argue with me about this all the time. I literally cannot touch a drop of iodine solution or I break out in hives. Anyhow, my question to you is - because I'm so highly allergic to fish and shellfish, what would you suggest I increase in my diet to get more DHA and Omegas? I tried taking flaxseed oil once and had to go to the ER because of an episode of PVC's, which the Dr. said Flaxseed oil can have that side effect on some people. Thank you! tiredrummertube tiredrummertube 3 years ago I guess I missed the part where it has been found that cancer can use ketone bodies. THX so much for these videos ! 1 Cristina Campbell Cristina Campbell 1 year ago 42 hours into my fast. Watching to keep up my mood. 12 Jesus Rosado Jesus Rosado 2 years ago Excellent interview. AFH18 AFH18 1 year ago Doesn't mention anywhere in the title or description who the interviewer is. She's Dr Rhonda Patrick. A very knowledgeable person in the fasting field. 17 Bran Jay Bran Jay 1 year ago My gf has Lupus. She has been suffering for years and I has had an effect on me. I hope this message gets to someone with some advice. Do you think long term fasting would help her? Tosvarsan Tosvarsan 1 year ago I'm seriously shocked by the quality of this program. This woman is an incredible p;professional! 1 Kevin Kevin 3 years ago Does anyone know what the rules of thumb are for exercise during the fasting period? It seems problematic to do intense exercise, but was it directly addressed by Dr Rhonda Patrick or Dr Longo? 1 Time To Thrive Time To Thrive 3 years ago Good to see you back Rhonda! And thankyou for my knowledge fix! 1 zimam Gebremedhin zimam Gebremedhin 2 years ago I am so grateful that the universe brought me to your channel. I am now a new subscriber Antonius Black Antonius Black 3 years ago I love this guy and Dr. Panda! Thanks for sharing! 10 FoundMyFitness Paraná River Paraná River 3 years ago Dr. Longo sos un genio!!! Además que paciencia tiene para explicar de nuevo todo lo que ya dijo en su libro é outra entrevista. Un ídolo! Gracias. 2 amy rorris amy rorris 2 years ago I’m curious, does valter include fruit in his realm of healthy carbs? Really respect ur work!!!!! Ty!!!!! 1 Erik Lommel Erik Lommel 3 years ago excellent interview!!! 1 Grant Adamson Grant Adamson 3 years ago (edited) If you try the fasting diet that is sold by Dr Longo for say a 1 year period and your BP reduces accordingly does the heart adjust to this lower pressure? And if so when you come of the diet does the increase in BP suddenly cause a sustained spike in stress on the heart and in a quicker time frame than normal progressive increases in BP due to the usual causes? The Path of Eudaimonia The Path of Eudaimonia 1 year ago I am looking for great sources for learning more about time-restricted feeding and prolonged fasting, besides Valter Longo's book. Any recommendations? Sam Savage Sam Savage 2 years ago I love how he frames everything as a risk ... 1 Danny Danny 3 years ago (edited) When Dr. Longo says 5 days fasting mimicking does he mean just water for 5 days or just standard 8-10hr eating window? Thank you for another phenomenal video/interview. Jason Massey Jason Massey 3 years ago I have psoriasis and dysbiosis in my gut. Do you have any advice Dr. Patrick? Thanks! Top Gamer Top Gamer 3 years ago Welcome back! Love your big brained videos. 2 Þráinn Guðbjörnsson Þráinn Guðbjörnsson 3 years ago I have arrhythmia, mostly due to scar tissue I think, and it has had very debilitating effects on my life for many years. Since January I've been doing fast mimicking diet (FMD) every month; 5 day process. I basically just eat a mix of rice and avocado for the period. I have had extremely good results where basically everything has gotten better. If you have arrhythmia I recommend trying it. I suppose you should ask your doctor beforehand though. 4 aovint63 aovint63 3 years ago Given the multivitamins are basically 1-2 gram, nutritionally dense but without much if any calories, if I do a water fast for 24h to 48h and take multivitamin based on plants only (I use Garden of life Code) do I still get all the benefits from a fast? if not, what do I lose? Dakota Knight Dakota Knight 2 years ago I want so much to believe but I always have a hard time trusting researchers who have a personal financial interest in the thing they are researching. I think researchers should be rewarded for discovery but when money becomes the driver then bias is almost inevitable. I get really suspect when the representative product doesn’t go through FDA approval because efficacy doesn’t need to be proven. Even “independent” studies are problematic because someone has to fund those and if you look at disclosures you can usually find something that is suspect. 4 Venomenn Venomenn 3 years ago Guys. This the Mekka of information on fasting, on the freaking whole Youtube. Watch the whole video! 13 Sean O Sean O 1 year ago What affects, if any, are there on fasting by adding in micro-nutrients like vitamin c, b vitamins, and electrolytes? Are there any negatives effects to the benefits one gets from fasting by adding those in? Specifically, if you're looking for the renewal effects fasting has on the body, not to lose weight 1 jaykana jaykana 8 months ago Excellent, Rhonda please ,have Prof Longo and Prof Seyfried on together. Emma Jones Emma Jones 2 years ago first 10 minutes are very interesting. protein , IGF1 and aging is something Dr Grundy writes about in the Longevity Paradox. i sense some myth busting going on in the world of protein needs, esp of the animal sourced. Viorel G Viorel G 2 years ago One of the best videos I've seen. 4 chucky chucky chucky chucky 3 years ago Is there a connection between nrf2 pathway and vegfc connection to lymphedema and can they work together in promoting bennefits in treatment of the condition 2 Bill Pchajek Bill Pchajek 3 years ago i have been trying to regulate my autoimmune diseases with diet(type 1 diabetes, Graves disease, celiac, and arthritis). what would be the ideal diet for autoimmune disease? I am currently eating in a 6-hour window and have played with my macronutrients in that window. i would be willing to make any further dietary modifications necessary to improve. i currently follow low lectin protocols cutting dairy, legumes, nightshades and grains with the exception of corn and peanuts and a little cream in my coffee. Dragan Petev Dragan Petev 2 years ago It is mindblowing to me how the videos with the best information on the most important subjects in the world always have so little views, fewer likes and even fewer comments... All of this is evidence that people in general aren't interested in the stuff that really matters... 1 Nick Fisher Nick Fisher 3 years ago What about discovering potential igf1 receptor antagonists, would this be beneficial? Someone should look into cannabinoids in this regard. As in both mice and human tissue culture cancer studies, delta 9 THC has been shown to have; anti-angiogenic, anti-proliferative, anti-metastatic and pro-apoptotic effects on the non healthy cells exclusively. I hypothesized that some cannabinoids may work as an insulin receptor agonist, as my type 1 diabetic mother noted anecdotally that she could lower her blood glucose a little by smoking cannabis without having to inject insulin, also I get very hypoglycemic if i do strenuous exercise after smoking... evidence to me that some cannabinoids may work in similar fashion to insulin on a cellular level as far as glucose metabolism is concerned, without having elevated levels of serum insulin and the subsequent resistance or other more serious (inflamation & pro tumor etc.) side effects. This explanation of the igf1 receptor signaling pathways as related to cancer and aging really make me think that cannabinoids may also be taking an antagonistic role at the igf1 receptor (particularly in cells with a low immune response, such as old/damaged/cancerous cells). This might explain why and how cannabinods have and perform their selective anticancer properties. This seems like a workable hypothesis, and i presume there is little chance dr. Patrick will see this comment... But I would love to hear her thoughts on this, its possibilities, and maybe potential for therapeutic application. Thanks for reading ;-) 1 J Guarino J Guarino 3 years ago Dr. Patrick please make a video on ways to manage or heal ulcerative colitis / Crohns Disease. I would love to hear your perspective! 7 WYLO - Evelin WYLO - Evelin 3 years ago Water only fast saved my life. I had a thrombosis and in a 7 days the thrombus melt away. Without blood thiner! 20 mehi mehi 3 years ago I started watching your videos since I was 15 years old. Vv interesting stuff! 8 FoundMyFitness Piotr Podsiadły Piotr Podsiadły 3 years ago Thank you for new content! 2 Henning Øgaard Henning Øgaard 9 months ago I find it interesting that Rhonda Patrick said on Joe Rogan that she is following a ketogenic diet. I thought there was good research behind a plant based diet, as Longo says meat increases IGF-1. 1 The Path of Eudaimonia The Path of Eudaimonia 1 year ago Such a rich and fascinating subject. 1 Creative Creative 2 years ago I can’t tell if she’s 42 or 22... bravo Dr. Rhonda 👏🏻 3 Orbifold Orbifold 3 years ago With respect to autophagy, how does fasting compare to exercise? For example, is it better to exercise 6 hours (by riding a bike) or practise a 24-hour fasting? LP LP 3 years ago great video thanks! Jesse Ray Jesse Ray 4 months ago (edited) 16:02 (according to Dr. Longo) fasting magnifies the positive effects chemotherapy has on cancerous cells, and the patients didn't want to fast! OMG, are you fucking kidding me! If I had cancer, I would do everything I could do (within realistic possibilities) to fight against cancer, including fasting! It's not like it's some random unproven drug or treatment, it's literally only drinking water coupled with not eating for a period of time during chemotherapy treatment! Wow, I am completely dumbfounded by people sometimes! FUCKING WOW! 1 Stuart Tanner Stuart Tanner 3 years ago Dr. Rhonda is so warm and friendly and Dr. Valter has the emotional range of a grave stone!! Lol. I have his book and found it very interesting. Hopefully this interview will top up my knowledge. Dr. Patrick is there any chance you could do a podcast on IBS and IBD Please? I will be forever grateful. All the best 43 hi hi 2 years ago Excelente