Lifespan with Dr. David Sinclair pros and cons of meat diets and plant based diets.

My NMN Experiment 22.9K subscribers In this clip, Dr. David Sinclair and co-host Matthew LaPlante discuss the Links: Mouse genetics influence how diet affects lifespan - https://bit.ly/3qiBc9R Vegetarian dietary patterns and human mortality - https://bit.ly/31OCtMq A Mediterranean diet slows biological aging - https://bit.ly/3I1rcbd Plant polyphenols regulate lifespan in yeast - https://go.nature.com/3HWWGiB A Mediterranean diet is linked to reduced mortality - https://bit.ly/3fdDPDx Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla ... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai ... Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante 144 Comments rongmaw lin Add a comment... crazycrazycrazyadam crazycrazycrazyadam FoundMyFitness 426K subscribers In this episode, Rhonda explains what NAD+, why it is so important for aging and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, what animal and human data says and some concluding thoughts. NAD+ is crucial for our survival. Small amounts of it can be obtained in the diet, but the body recycles it to get most of what it needs. Unfortunately, day to day living plus normal aging can cause NAD+ levels to drop. This causes metabolic and mitochondrial dysfunction, as well as many of the other problems and conditions associated with aging like elevated DNA damage. NAD+ levels can go up when we exercise or fast, but NAD+ precursors like nicotinamide riboside and nicotinamide mononucleotide can also increase NAD+ levels in a dose-dependent manner. However, most of the data on NAD+ boosters comes from animal studies. Whether these boosters are effective – and safe – long-term in humans is still a big question. ▶︎ Get the episode's show notes, timeline, and more https://www.foundmyfitness.com/episod... Chapters 00:00:00 - Introduction 00:01:01 - Aging 00:02:47 - Overview 00:07:35 - Depletion 00:09:19 - Supplementation 00:11:26 - Animal studies 00:13:47 - Cancer 00:15:57 - Dosage 00:25:44 - Human data 00:28:25 - Storage 00:29:00 - Recap ▶︎ Detailed overview of NAD+ https://www.foundmyfitness.com/topics... ▶︎ Detailed overview of nicotinamide riboside https://www.foundmyfitness.com/topics... ▶︎ Detailed overview of nicotinamide mononucleotide https://www.foundmyfitness.com/topics... ▶︎ Did you enjoy this podcast? If you want to support me in getting more of this free information out to the public, please consider becoming an FMF premium member! In doing so, you'll also get access to exclusive member benefits, such as a private podcast feed offering early access and occasional bonus episodes, monthly live Q&As with me, a members-only library that includes presentation slides with all of the supporting figures, graphics, references, and quotes. Also included are Rhonda's private notes on topics discussed in the podcast, bi-monthly member-exclusive Science News Digest email, and more. Thank you for your consideration! Learn more here: https://www.foundmyfitness.com/premium ▶︎ Gain valuable insights by running your raw genetic data through the FoundMyFitness report https://www.foundmyfitness.com/geneti... Chapters Introduction 0:00 Aging 1:01 Overview 2:47 Depletion 7:35 Supplementation 9:19 Animal studies 11:26 Cancer 13:47 Featured playlist 31 videos Just Me FoundMyFitness 1,255 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 2 years ago (edited) 00:00:00 - Intro. 00:00:48 - Nicotinamide riboside supplementation in humans has been shown to raise NAD+ levels in white blood cells. 00:02:47 - Overview of NAD+ 00:05:12 - NAD+ plays an important role in mitigating DNA damage. 00:05:30 - Excessive DNA damage can decrease NAD+ levels by 20-30%. 00:05:42 - Lymphoblastoid cells from centenarians show increased PARP-1 activity. 00:05:55 - Between different species of mammals, higher PARP-1 activity is strongly associated with a longer lifespan. 00:06:36 - Lower organism evidence: A second copy of SIR2, a yeast sirtuin, gave rise to a 30% extension of lifespan. 00:06:43 - NAD+ is required for the activation of sirtuins, which epigenetically regulate a variety of stress response-related processes. 00:07:03 - Energy stress, such as from fasting, exercise, or caloric restriction, increase the NAD+:NADH ratio. 00:07:37 - NAD+ becomes depleted in the brain, heart, and skeletal muscle as we age. 00:08:13 - Decline in NAD+ levels have been associated with many broad categories of clinical disease such as neurodegenerative, cardiovascular, infectious, musculoskeletal. 00:08:48 - NAD+ supplementation has been shown to increase lifespan in models of aging in yeast, worms, and rodents. 00:09:48 - In contrast to de novo synthesis, the predominant source of NAD+ in the body is via the salvage pathway, which is subject to feedback inhibition by nicotinamide. 00:11:56 - Animal studies have shown nicotinamide riboside supplementation is able to increase insulin sensitivity, increase endurance and strength, reverse mitochondrial damage, increase mitochondrial biogenesis, and reverse muscular atrophy. 00:12:30 - Nicotinamide riboside has shown positive effects on the brain in animal, such as increased neurogenesis, decreased cognitive deterioration, decreased amyloid-beta production, and increased synaptic plasticity. 00:12:50 - Nicotinamide mononucleotide has been shown in animals to counter an obesogenic diet, improve markers of metabolic health, improve heart function, and improve cognition and memory. 00:13:10 - A 12-month dietary study of nicotinamide mononucleotide suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies in mice. 00:13:47 - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice. 00:15:57 - Plausibility of dosing: comparing animal and human doses. 00:18:05 - Tissue-specific metabolism and bioavailability of NR and NMN. 00:24:32 - Oral administration of NAD produces NR and NMN in the intestine. 00:24:19 - Intravenous administration of NAD, rather than its precursors, shows interesting results: an increase of NAD content and sirtuin expression in the hypothalamic region of the brain. 00:26:15 - Human study #1: 250mg of NR + 50 mg pterostilbene increased blood NAD+ levels by 40%, while a double dose (500 mg NR + 100 mg pterostilbene) increased blood NAD+ levels by 90%. Additionally, there was a decrease in blood pressure, and ALT (a marker for liver health). 00:27:12 - Human study #2: 500mg NR twice daily for six weeks increased NAD+ levels in white blood cells by 60%. 00:29:08 - Concluding thoughts and recap. 252 pablopolski pablopolski 2 years ago Concise, comprehensive, and articulate. I don't even need to speed it up to get through the information. Well done. 373 FoundMyFitness DAVID EVANS DAVID EVANS 2 years ago (edited) Rarely do we find in the study of nutrition, detail like presented in this video, yet at the same time Rhonda is able to get to her final conclusion without leaving everyone in the weeds. Extremely well done. Combined with Dr. Nicholas Pericone and Dr. Jason Fung, we are starting to get a handle on what is necessary to make critical changes in our life for optimal health... 7 Chuck A Chuck A 2 years ago Congratulations Rhonda you have smashed the record for total mentions of "Nicotinamide and Nicotinamide Mononucleotide" without stuttering, giggling or entering a comatose state. Kudos! 183 Chris Benton Chris Benton 2 years ago Excellent lecture, well put together, a good balance of pros and cons, useful diagrams and a clear summary at the end. Perfect presentation technique. 111 FoundMyFitness Cat Man Cat Man 1 year ago I've been taking a low doseage of NMN for a couple of weeks now. I started with 100mg in the morning and 50mg at night on the first day, then 50mg the next morning. I hadn't been expecting any results for at least a week or so. About 2 hours after taking that second morning dose I went out shopping and was astonished to find my legs wanting to walk faster and faster, as if under their own volition. I've not walked like that in almost 7 years. I've had a number of strokes and suffer numerous symptoms, manly to do with inhibitted activity levels. My mind is foggy most of the time and the NMN has not done anything for that, but I certainly feel the difference in energy levels, it's really amazing. I also found that after a few days I had to stop the NMN for a couple of days as it seemed to be making me feel more groggy, so I now take it 2 days on, 2 days off. The brand I'm using is an American Brand called RevGenetics, and it's called Advanced NMN, in capsule form. I know it's also available in powder form too. It's quite expensive even in capsule form and would cost the earth to take it regularly at the doseages recommended in this video, but I can assure anyone that the effects at the doseage I am on are truly amazing. 4 Rich Rozmarn Rich Rozmarn 2 years ago Great presentation, thank you so much. I take NAD with R-Lipoic acid, D-Ribose and Resveratrol for a pre workout. I work out 3-4 times a week and feel as good as when i was 40, now 60. 51 Scott Joshua Scott Joshua 2 years ago What a herculean effort and a testament to your ability to grind it out for hours on end. You’re incredible Rhonda. 15 FoundMyFitness No Limit No Limit 2 years ago A very professional very well presented lecture . English is my 4th. language and I did not have any real problem to understand it and learn from it. Doc, I really appreciate your effort to create this video. Thank you. 7 FoundMyFitness Tony Westbrook Tony Westbrook 2 years ago I learn so much here by your presentation and documentation. Thank you Rhonda for taking, what must be a lot of time to put all of this documentation together! 28 FoundMyFitness Dr. Nancy McClure-Galli Dr. Nancy McClure-Galli 2 years ago So great to have the micro cellular pathways broken down this way. Also, the analysis of both animal and human studies. Thank you so much for the effortless way you explain potentially mind boggling processes. Helps so much in the decision making process. B Szlado B Szlado 2 years ago Great summary of the topic! I was desperately trying to find actual human published data about NAD+ decreasing with age, but other then the two studies you mentioned, couldn't find much. In those two studies though, sertuin activity actually didn't decrease; there was significant difference between men and women, and the NAD+ decrease was extremely small (vs. the 50% David Sinclair commonly mentions), and in fact looking at the graph, it was quite variable, with some 30 year olds having the same level as 60+.. .so I really wonder if the marked "decrease" in NAD+ everybody goes on and on about is actually a comparison of an active 20 year old vs. a sedentary, unhealthy 50-60 year old; ie. isn't the life style more important than the horrendously expensive NMN and NR supplements? 1 Dustin Phillips Dustin Phillips 2 years ago Thank you for the video. I have been taking Tru Nigen (NR) for about two months at 350 mgs. What I have noticed is a slight increase in energy, and focus. I feel like I have also lost some body fat. However, I stay in Ketosis and use intermittent fasting 4 days a week. However, I plan to stop taking it once my bottle runs out because of the information presented in this video. I don't see the benefits outweighing the potential downsides. Thanks again. 11 profitfever profitfever 2 years ago So glad you covered this. Been listening to lifespan on audio book and he's one of the leading scientists on this research. 8 Gregory Colvin-Garcia Gregory Colvin-Garcia 1 year ago Rhonda, I've heard Dr. Sinclair say he takes 1gram of NMN daily but in reading his book and listening to multiple interviews I'm not sure on the best time metabolically to dose and if there is a "minimum effective" single dose. Currently, I take 250 mg, 3 to 4 times per day sublingually but it occurred to me that each one of these single doses may be below the threshold of effectiveness... 2 Ramon Mensink Ramon Mensink 1 year ago Great video Rhonda! I was wondering if it makes sense to take a NR/NMN supplement while also ingesting carbs/protein/fat. As you also explain in the video, the NAD/NADH ratio in the cell increases when fasting/CR/exercising. Then such a NAD boosting supplement would need to be taken in a fasted state wouldn't it? Or is the pathway of either NR/NMN supplement somehow separated from the metabolic pathway when a cell is in a fasted state? 2 quigonreturns again quigonreturns again 3 months ago Hello! Would love to know your thoughts on methyl group depletion as it relates to Niacinamide supplementation. I have been taking it at 500mg/day, with no ill effects. However, I am cautious about the long term affects of supplementation. Thanks! And love your content! B D B D 9 months ago (edited) Excellent!! Conclusion: Fasting, less calories, regular exercise increases NAD level👍 We all need to wait for using supplement at this point till more data available! 1 David David 2 years ago Great video Rhonda, thank you for all you're doing and the quality information with such strong scientific detail. 2 SpockBoy SpockBoy 2 years ago (edited) Thank you so much for bringing us this information Doctor. Using your great intelligence for altruistic purposes is both rare and wonderful. 3 Steve Wright Steve Wright 1 year ago Many thanks for this detailed walk through! I think correctly identified this is all at an early stage of discovery - perhaps usefully highlighting the key importance of NAD in the cell energy economy, but (to my mind) now pointing to the need to reduce NAD depletion. A whole food plant based (WFPB) diet being inherently low inflammation - perhaps best indicated by White Blood Cell count: https://nutritionfacts.org/video/what-is-the-ideal-white-blood-cell-count/ Also points to a need to remove senescent cells regularly - probably by a number of 5 day water fasts over the year. Lastly - not a bad shout to pay attention to Vit B3 status - if this is insufficient NAD production is likely to be throttled... Thanks Rhonda for this review - appreciated! Morrocco Method Int'l Morrocco Method Int'l 2 years ago So helpful + informative for learning about aging. Thank you for this video! 2 Joseph Khadige Joseph Khadige 1 year ago Great presentation Doc. Thank you. Please excuse my ignorance in this matter but to make sure I am understanding it accurately, if a cancer patient is regularly fasting and exercising (which leads to increase of NAD levels) would that increase the spread and developing of the cancer cells? KenG KenG 6 months ago Excellent analysis and much appreciated! I love your presentation speed and style! 1 Roger Bowman's Fitness & Wellness Coaching Roger Bowman's Fitness & Wellness Coaching 2 months ago Stellar presentation as always, thank you Dr. Patrick! gururaj bsavakar gururaj bsavakar 2 years ago Congratulations! Firstly for the , pleasant, patient presentation, with amazing revelations of test results of NAD, decline with age, using boosters of NAD, & Alternate pathways which work usually but with exceptions!!! Extremely A Great MASTERLY STUDY/ & presentation of all pros- cons of all eventualities . With a final recap!! Thanks for this useful educative share! Many regards! 5 FoundMyFitness Ivan Valdez, PhD Ivan Valdez, PhD 10 months ago Fantastic job, Dr. Patrick. Do you think that sublingual NR/NMN would be effective at increasing NAD+ levels in different tissues And not just blood, similar to Intravenous administration, by bypassing the liver? Cris Clourt Cris Clourt 2 years ago Thanks Rhonda for your amazing research! Do you know what type of trans-resveratrol is best? Does it have to be organic etc...? 2 Vedran Simic Vedran Simic 2 years ago Very interesting. From your video's from Satchin Panda I learned the benefits of time restricted eating regaring insulin sensitivity, sleep, cardiovascular aspect etcetera. Do you have any information whether NAD+ increases also with time restricted feeding and which window of eating you should use? Or is there only information about fasting and increasing NAD+ and if that is the case how long you should fast for increasing NAD+. 1 a2audrey a2audrey 2 years ago I’ve been taking 750mg of NMN + 500mg resveratrol for 6 months. I’m 61 and in good, but far from great shape. My muscle stamina and overall energy are way higher than when I began. I also have noticeable reduction in inflammation in my leg that was damaged in an accident and where it had been chronic for many years. The reduction in inflammation alone keeps me on it, but feeling a lot better is great too. 42 Karla Jean Karla Jean 2 years ago 5 months later and I'm still coming back to relisten to this video. Very informative and so well put together. 2 Noveleffect Noveleffect 2 years ago I really appreciate the chemical reaction explained to me along with the reaction diagrams. So rare to find anything this thorough 4 Harvey Holloway Harvey Holloway 2 years ago Great video. I am 70 and a health fanatic, and still in perfect health. I have a massive coordinated program that did not include this. Now I will be going out today and buying Niacin. I am going to start immediately. Have a wonderful day. ☺😎🐰 4 N C N C 2 years ago I've been doing lots of reading and this is by far the most in depth breakdown I've seen on NR/NMN yet. While I am really impressed with anecdotal evidence of NAD supplements, I am erring on the side of caution. Personally, I'm going to hold off on purchasing supplements until more clinical trials come out so we know proper dosages and whether or not this even carries over from mice to humans. Anyone else feel the same way? If it turns out this is safe, easily replicates in humans etc then I will consider supplementing. 2 Andrew Moore Andrew Moore 1 year ago Superb. So much information explained so efficiently in 30mins. I feel very well informed now, thank you! 1 Ja Wi Ja Wi 2 years ago Good work! You certainly did the research and can explain it with great accuracy. Thank you. Tom Provan Tom Provan 2 years ago This is definitely the best most informative and comprehensive piece of information so far delivered on this topic as far as I am concerned thank you for this video Rob Lovegreen Rob Lovegreen 2 years ago Because of you, I started loving myself with broccoli sprouts. ❤️ I grow them too. Sulforaphane for the win! Thank you 🥦 60 Kuo-Ying Wang Kuo-Ying Wang 6 months ago Excellent and brilliant work. Thank you very much indeed. The literature reviewers are amazingly detailed and strikes the key points of the findings from the researches. Aldous Orwell Aldous Orwell 2 years ago Beautiful! Very comprehensive! Question: does DNA repair have a circadian rhythm? If so, would it be better to take NR in the evenings? Thank you! :-) Christina Lawhorn Christina Lawhorn 2 years ago ** Due to a serious case of mold poisoning I have been on NAD+ IV's for 6 months... they literally saved my life.. I have never had oral NMN or NR. However I would highly recommend anyone with a health issue try NAD+ IV's. There are numerous accounts of people turning their life around due to NAD IV's not precursors. Best wishes to each of you! 1 pravoslavnik pravoslavnik 2 years ago Just found your channel/videos. Your presentations are "spot-on," as the modern expression has it. Loaded with information. Love your vids. I shall be watching them all. PLEASE keep up the good work ! 2 FoundMyFitness Optimize with Science Optimize with Science 2 years ago It is a fascinating topic and I love how scientific Dr. Patrick approaches it! 41 FoundMyFitness alfred Vincent alfred Vincent 1 year ago Great concise presentation as always. Thank you. 2 June Allison June Allison 1 year ago Dr. Rhonda this is the best explanation I've heard on this topic. So thorough and well thought out. Thank you❤ 2 uncle Joe uncle Joe 2 years ago Exciting developments. Great to know scientists are working so hard on our behalf in this crazy world. In the meantime I'll continue my exercise, sauna, and clean diet. Thanks! 1 Cuenta de Youtube Cuenta de Youtube 2 years ago Best unbiased recap of NAD+, NR and NMN. Thank you! Suscribed! 3 C H C H 2 years ago (edited) Regularly growing broccoli sprouts for a couple months now, I put them in my daily smoothies for myself and my family thanks to Dr. Rhonda Patrick. Thank you for all this free info, truly is life changing 36 FoundMyFitness Ken Otwell Ken Otwell 2 years ago Great data - but leaves me with one big question - how much does exercise increase NAD+ and how does that compare with supplementation? Also - is there any synergy between exercise and supplementation? 64 Larry Tate Larry Tate 2 years ago Dr. Patrick thank you for sharing your knowledge. Could you please consider doing a video lecture on CBD and it’s benefits and possible negatives? Thank you Jeff G Jeff G 2 years ago Great video. Now I'm wondering how long it will be until we have solid data on positive effects as well as dosage sizes and methods to experience those effects. Years? How many? Thomas 3108 Thomas 3108 2 years ago Hello, I have one problem taking NMN. Hope you can help with your knowledge 😃🙏 I take 0,5 - 1 gramm Resveratrol in Oliveoil, 0,5 gramm of NMN and 1 gramm of TMG. I started taking TMG as I noticed, that after about 3 days I feel a certain pressure on my heart or let's say on the left side of the breast and I feel like having higher blood pressure. Then I stop the life extension treatment and everything is fine again. When I take only Resveratrol or only TMG this phenomenon doesn't appear. I thought with taking TMG this would stop, but that's not the case. After starting again the same reaction appears. I bought NMN even from Prohealth. The same thing. The dose is really not that high, so I am wondering as the studies don't have such results. I am 45, 1,75 m and about 83 kg. So what's your opinion on that? Thanks in advance, Thomas 1 Bakhtiyar Neyman Bakhtiyar Neyman 2 years ago Instantly one of my favorites videos on Youtube. Thank you so much, Rhonda! 2 Shaji George Shaji George 1 year ago Hi Dr Patrick: Very interesting presentation. In light of the data that you showed that there is a real possibility that NMN and NR are converted into NAM and recycled in the salvage pathway to make NAD, why not consume Nicotinic acid? The recent paper in Cell metabolism showed that NA supplementation in humans with mitochondrial myopathy in a small clinical study showed 2.3 fold increase in muscle NAD in the patients (not in healthy controls) and an 8 fold increase in blood NAD in these patients (5 fold in controls) at 1 g/day over 10 month (escalating dose from 250 mg to 1 g to reduce flushing even though they used a slow-release version of NA). This is much more of an NAD boost than NR or NMN which probably supports the theory (from the metabolic flux study you mentioned) that NMN and NR are converted into NAM and cycled through the salvage pathway thereby negating the advantage of NR and NMN. However, the authors studied only muscle and blood, so it is not clear if NAD levels in other tissues also increased. Other studies have shown that IV administration of NAD can increase NAD levels in brain. So if blood NMN can be raised 5 or 8 fold, then it can cross into the brain (If I remember right, there is some data to show NAD crossing BB barrier although I am if more studies will show it through the NAM route). NA is very cheap and has good safety profile (having been used in high doses as an anti-cholesterol agent in the past). Slow release NA can ameliorate some of the flushing even though some suggest based that the slow release form may cause liver toxicity (very limited data). Would like to hear your thoughts on using NA instead of NR or NMN. Equs Narnd Equs Narnd 1 year ago I'd like to see you do a video on the role of Niacin (Nicotinic acid) on supplying the molecules for the manufacture of NAD+ 11 carpe diem jonah carpe diem jonah 2 years ago (edited) So what are the best relative food sources of NMN? And the best relative food sources of Nicotinamide Riboside? Are some of these foods significantly higher in their capacity to boost NAD levels? Hoping to get it aboard the food supply so there is the safety of letting the body metabolize as needed. SmartCookiesDontCrumble SmartCookiesDontCrumble 1 year ago Thank you so much for giving this teaching on this topic. Valuable information!🥰 2 Rick Kowalchuk Rick Kowalchuk 2 years ago It seems to be a key component involved in aging and possibly reversing the process! Dan O'Hanlon Dan O'Hanlon 1 year ago Very helpful — comprehensive — much appreciated! 2 Waskel E. Wabbit Waskel E. Wabbit 1 year ago (edited) I have been taking 300 mg a day of NAD+ for almost a month. Took about three weeks before I started noticing a difference. It is very subtle but that might be a good thing. There's a fine line between feeling like doing something or not. I have had chronic fatigue for all of my adult life. I am 68 now. Been looking for the magic pill for that long. Getting ready to order my second bottle and I would recommend to anyone with low energy levels or just to possibly live longer. No one I've talked to has heard of this stuff. Would like to get some friends to try it to see if it helps them too. 1 jackwelshh100 jackwelshh100 2 years ago (edited) Very interesting episode. Fantastic work! One question comes to mind: We know that resveratrol is a SIRT-1 activator but are there identified compounds that increase PARP-1 activation (for us with non-supercentenarian genes)? I supplement with NR and resvetral. If there's a PARP-1 specific activator compound, it might be an interesting addition to the mix. 4 David Alzate David Alzate 9 months ago I guess in the section on depletion, it's important to include the studies of CD38, CD157, and PARP. These molecules are impacting the depletion of NAD+. Casey Connor Casey Connor 2 years ago Fantastic as usual! Thanks for the great information! Hey, if you get a chance to circle back on the subject of eating fresh ground broccoli seeds at some point that would be great. Many of us like the taste of them! Or don't notice it when added to food! Erucic acid might be a consideration? Thanks! 2 NADIOL™ NADIOL™ 9 months ago Amazing content as always Rhonda. Dr. Steve Hruby, D.C. Dr. Steve Hruby, D.C. 2 years ago Thank you Dr Patrick this is above and beyond anything that is out there. 1 FoundMyFitness Trey IM2 Trey IM2 2 years ago I had literally finished my bottle of NAD3 the day before this vid dropped. Took my last TMG (DEFINITELY take this with it for methylation. I also take an activated B complex for additional methylation regularly) this morning (skipped yesterday, and I think I took an extra NAD3 by accident so it wasn't 1:1). I had been on this for 4 months straight after taking a month or so off with a 2 or 3 month straight intake prior. I don't know if it improved anything because I take a ton of supplements and herbs to improve my overall health. I plan to take a month or 2 9ff before getting back on NAD3 Wolfram Luchner Wolfram Luchner 2 years ago Exemplary summary. I love how dense with information your videos are. Quite a rarity on youtube! Keep up the good work and thank you for your high quality content! 7 FoundMyFitness Josh Woodle Josh Woodle 2 years ago (edited) Dr. Rhonda, since Dr. Jed's video, I've been eating just the broccoli seeds. Is there any way you could do a video on consuming broccoli seeds vs. sprouts? I burr grind them and sprinkle over food. Very interested in this! AJ Hege AJ Hege 2 years ago Appreciate the info! What are your findings about NADH (NAD bonded with a hydrogen ion)? I hear it has a better delivery system from a doctor on the Ben Greenfield podcast. Peter Davila Peter Davila 2 months ago (edited) I'm 66 years old. I started taking 1g a day of Apigenin a few months ago. Apigenin is one of the ways to raise NAD+. It is amazing how much energy I have now. It feels like the energy that I remember having in my 30s. In addition, in conversation with my neighbors, they have commented that I seem to look younger every year, instead of older. I also take Metformin, even though I do not have diabetes. I also do a lot of intermittent, 3 day water fasts. I'm planning to start on 1g of Fisetin a day for 5 straight days every month in the next few weeks. My diet is free of meat. I do eat sardines, salmon and flounder. Lots of nuts (Walnuts, Cashews), seeds (Flax, Hemp, Chia). Dark Chocolate (80% cocoa). I do drink lots of coffee. I don't drink cow milk but almond milk instead. I don't drink alcohol. Live Long Enough to Live Foreever. Isabella Holden Isabella Holden 2 years ago Amazing video. Thank you for the brilliantly explained content.🇿🇦😎🙏 5 FoundMyFitness Ron RG Ron RG 2 years ago Dr. Rhonda amazingly insightful analysis of the data! Love the topics and videos you make . Thank you so much 1 firehorse_44 alpha-omega firehorse_44 alpha-omega 2 years ago Excellent lecture. Thank you for this presentation Dr. Cheers 10 Entropy Wins Entropy Wins 2 years ago I'd be interested in a video on pterostilbene and thoughts on supplementing that. Kunverji Hirani Kunverji Hirani 1 year ago Hi Rhonda :-) So practically, what do you recommend? Take NMN first thing in the morning? - then how long should you wait before having breakfast? Or can you have breakfast straight away after taking NMN? Many thanks :-) Vijai shankar Srivastava Vijai shankar Srivastava 3 months ago Highli informative video based on different experiments on NMN AND NR. It’s doses n application well covered. Dave Soko Dave Soko 11 months ago Can you boost your NAD levels by taking Niacin or do you have to use the other forms such as nicotinamide riboside or are they the same thing? 1 rzomg rzomg 2 years ago Amazing skills to flood my brain with huge amounts of information. I know how its gonna feel when AI's are smarter than us all its the same feeling I get when I listen to Dr.Rhonda 2 mooky wilson mooky wilson 2 years ago DOC!!!! your the best! I wish there were more docs like you. 4 Launch Medical Media Launch Medical Media 1 year ago This is a wonderful video. We will probably be sending our patients this video when they ask about NAD+ from now on! 2 months ago (edited) Vince, the conversation of Plant vs. Meat completely changes when you consider the latest means of assessing protein bioavailability via the DIAAS (Digestible Indispensable Amino Acid Score) relative to the old method used by most industies still PDCAAS(Protein Digestibility Corrected Amino Acid Score). The protein quality you get from plant based products are significantly reduced in bioavailability in humans relative to the calculated amounts on the dietary labels. On top of this MANY "plant based meats" and "plant based products" are lathered highly processed and unstable seed/vegetable oils that highly susceptible to oxidation and are prone to peroxidation cascades in the body and harm the cardiolipin in your cell's mitochondria, doing the opposite of what NMN supplementation is used for. Okinawans are long living more from the aspects of their diet (fresh organic resistant starches native to the Islands, high omega 3 fish, CONSTANT exercise and outdoor activity for vitamin D absorption, and most importantly, unlike mainland Japanese they never adopted Western feeding windows, so they are defacto intermittent fasting. Not that "they are plant based." And the one negative affect of Animal meat consumption, TMAO(Trimethylamine N-oxide) having cancerous properties when carnitine is broken down in the intestine can be completely mitigated by consuming Garlic for the Allicin that breaks down TMAO in the gut. You can mitigate the worst aspect of meat consumption on longevity by just having fresh Garlic and letting it set for a few moments to optimize your Allicin. All while getting the most nutrient dense and bioavailable content inside you, while only need a little bit of natural fructose from something like a strawberries/blueberries for helping to stop Free-testosterone getting bound up in the SHBG after working out. I think Sinclair is seeing the wrong elements in a lot of these "longevity diet" and attributing net positives to practices that in a vacuum may not be as longevity inducing as he is conveying. 18 My NMN Experiment Spoudaois Spoudaois 2 months ago When I went vegan my cholesterol went from 265 to 119. My arthritis completely went away.. I now weigh the same as I did in high school. I feel like I got 15 years back . People think Im about 10 or more years younger than my chronologic age. 5 My NMN Experiment Tim Reynolds Tim Reynolds 2 months ago (edited) I have noticed in all of his comments he mentions fasting or you can do fasting. Fasting really is the answer you get all of the benefits without taking any of these supplements. While I do take NMN I take it less often because I do fasting regularly. 3 My NMN Experiment LaaneyChoonz LaaneyChoonz 2 months ago BCAAs, particularly Leucine builds muscle, "which is why you feel good if you eat red meat... But what is actually going on is deleterious. In the long run (abstaining from meat) can do something better for your health. It can turn on autophagy" 1 My NMN Experiment Spoudaois Spoudaois 2 months ago All primates evolved as plant eaters. Humans have the highest amylase in our saliva and we evolved to eat mostly starch. We can eat meat but after age 45 it makes us sick because we cannot clear TMAO as well from the kidneys. In addition animal products raise our cholesterol. 3 My NMN Experiment nonrepublicrat nonrepublicrat 2 months ago Back in the days when people hunted much more than they farmed, we didn't have all these chronic health issues that we have now. "Native Americans" ate bison, NOT kale. 18 My NMN Experiment Barbara Lachance Barbara Lachance 2 months ago Vince, are you back in dubai?? You should try the DRYP yoga studio, it's hot yoga at 37c definitely gives a shock to the body, all they miss is a cold pool to jump in afterwards 😂 2 My NMN Experiment Moksha Lani Moksha Lani 2 months ago "A study done by the Adventist Health Group..." yeah, that's not going to be biased in any way. 3 My NMN Experiment Morgan Miller Morgan Miller 2 months ago The writer of the blue zones is wrong about the diet, and has massive bias against meat, purposefully leaving out the significant amount of meat in the diets. Also, David, can you please talk about the French??? 1 My NMN Experiment Christopher Ellis Christopher Ellis 2 months ago Plant-based: herbivores , eat herbivores! 7 My NMN Experiment markotrieste markotrieste 2 months ago Statistics about longevity of vegans are subject to the "healthy user" bias. 2 My NMN Experiment Alex M Alex M 2 months ago why is David so sad? just have a look at Paul Saladino's podcasts - he is always happy. Must be the meat? 5 My NMN Experiment Pluvo2for1 Pluvo2for1 2 months ago Unfortunately this is a strike against Sinclair for me. 5 My NMN Experiment Donald Winston Donald Winston 2 months ago I wish I liked fish. Any kind of seafood makes me gag except canned white albacore tuna. But that is probably contaminated with mercury. 1 My NMN Experiment big dave big dave 2 months ago Dr Shawn Baker….learn the truth about the Carnivore way of life. We’ve been lied to our whole lives 4 My NMN Experiment Ivan M Ivan M 2 months ago There is a new video from Bart Kay “David Sinclair DEMOLISHED” , what you think about th #Food #DavidSinclair #Longevity What to Eat & When to Eat for Longevity | Lifespan with Dr. David Sinclair #2 1,518,472 viewsJan 12, 2022 David Sinclair 202K subscribers In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a "low energy state," which can be induced by a period of fasting, combats aging and promotes health. They also walk through research that points to the benefits of a mostly plant-based diet for slowing aging and offer key insights into when to eat and what to eat to maximize longevity. #Food #DavidSinclair #Longevity Thank you to our sponsors: Levels - https://levels.link/sinclair Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introducing Episode Two: What to Eat & When to Eat for Longevity 00:01:10 Thanking the Sponsors 00:04:36 A Starting Place for Longevity: Eat Less Often 00:08:04 Caloric Restriction is an Evolutionarily Conserved Anti-Aging Strategy 00:09:52 Dietary Longevity Strategies are Accessible (and Save Money) 00:11:39 A Low Energy State Triggers a Genetic Pathway Involving Sirtuin Activation 00:13:10 NAD+ is Elevated by a Low Energy State 00:15:23 Fasting, mTOR, and AMPK 00:17:37 Data in Humans vs. Model Organisms 00:21:24 Evidence that Fasting is a Pro-longevity Intervention in Humans 00:24:00 Evidence that Fasting can Attenuate Human Disease 00:25:11 Different Fasting Regimens 00:29:42 Focus on Time-restricted Feeding (≥ 16 Hours of Fasting) 00:33:26 Continuous Glucose Monitors 00:34:24 Genetics Influence How an Intervention Affects Aging 00:36:51 A Trick for Fasting: Filling your Body with Fluids 00:38:44 Intermittent Fasting with Adequate Nutrition (IFAN) 00:40:00 Things to Avoid: Excess Sugar and Protein 00:45:16 Branched Amino Acids, Red Meat, and mTOR 00:47:53 Plant-Based Diets Protect Against Aging 00:51:44 The Okinawa Diet and Blue Zones 00:54:16 Xenohormesis 00:58:16 Main Takeaways 01:04:12 Obesity, Eating Habits, and Aging 1:05:54 Metabolic Winter Hypothesis 01:06:44 Preview for Episode 3: Beneficial Stress 01:07:23 Options for Subscription and Support Links: Dietary restriction extends lifespan in dogs - https://bit.ly/3FlDo4y Intermittent fasting in patients with metabolic syndrome - https://go.nature.com/3FggKKZ Alternate day fasting in healthy, non-obese humans - https://bit.ly/3HXGptH Time-restricted feeding in humans with prediabetes - https://bit.ly/3ffZWct A 24-hour fast reduces inflammasome activation in humans - https://bit.ly/3fwDc8t Fasting and diabetes - https://bit.ly/3rdtRHQ Intermittent energy restriction and multiple sclerosis - https://bit.ly/3HV7i1o A fasting-mimicking diet in patients with breast cancer - https://go.nature.com/3flcbV2 Mouse genetics influence how diet affects lifespan - https://bit.ly/3qiBc9R Vegetarian dietary patterns and human mortality - https://bit.ly/31OCtMq A Mediterranean diet slows biological aging - https://bit.ly/3I1rcbd Plant polyphenols regulate lifespan in yeast - https://go.nature.com/3HWWGiB A Mediterranean diet is linked to reduced mortality - https://bit.ly/3fdDPDx Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters Introducing Episode Two: What to Eat & When to Eat for Longevity 0:00 Thanking the Sponsors 1:10 A Starting Place for Longevity: Eat Less Often 4:36 Caloric Restriction is an Evolutionarily Conserved Anti-Aging Strategy 8:04 Dietary Longevity Strategies are Accessible (and Save Money) 9:52 A Low Energy State Triggers a Genetic Pathway Involving Sirtuin Activation 11:39 NAD+ is Elevated by a Low Energy State 13:10 3,290 Comments rongmaw lin Add a comment... Juan Pablo Aranovich Juan Pablo Aranovich 5 months ago This was a fantastic episode. Just sharing my notes here. Main takeaways: 1- Eat less often. 2- Avoid sugary drinks and foods. 3- Reduce meat intake for longevity. 4- Its never too late for dietary changes. 5- Find veggies that have been stressed out (organic, colorful veggies) 6-Never start a meal with sugars, if you do eat them at last (desert). EAT LESS OFTEN -There is a genetic pathway that gets triggered by low energy. These genes (sirtuins) respond to low energy (low glucose levels-caloric restriction), high heat, low amino acids, high salt (stressors). -----They take care of the DNA repair and the stabilization of the epigenome. -When the body is hungry, the body makes NAD (fuel for the sirtuins). -Two ways to activate sirtuins synthetically: 1) Use some molecules 2) NAD booster. Longevity genes: Mtor: protein that registers amino acids. Allows the cell to build things. Not a recipe for longevity. Activates autophagy. Ampk: goes up when hungry. Makes more mitochondria (important for making energy) Sirtuins Fasting: - Metformin: mimics fasting. - Time Restricted Feeding: At least 16 hours. - Liver compensates for the lack of food. Glucose neo-genesis. It overcomes the feeling of hunger. The liver starts making glucose at a steady level. Sugar: big killer. It spikes glucose. Glucose shut down sirtuins and ampk. Defenses against diseases and aging shut down. Protein: we should avoid high protein red meat diet for longevity. It inhibits mtor. Amino acids: three important. Leucine, isoleucine, and valine: BCAAs. Are used to sense protein intake. The sensor is mtor. The mtor activates when you get them. Mtor repairs and build muscle. In the short run, this is good for building muscle etc. But in the long run, mtor is the responsible for autophagy, which is key to longevity. Plant based diets: the more vegetarian you are, the longer you live. The best, Okinawa diet, is plant base diet with fish - (probably because of Essential fatty acids) Humans grew COLD and HUNGRY. Now we live at warm houses with food available all the time. Let me know if you want me to keep posting these notes, I am on Twitter @juampiaranovich 2.5K ANGELICA LINFESTY BLASCHKE ANGELICA LINFESTY BLASCHKE 5 months ago (edited) I keep discovering that I had it right all along! Honestly this is how I have been eating and I was called a bad mom for not having sweet food laying around for my children and most days we would fast. We have never been sick. Now my children are all grownup man between the ages of 26-30 and once they left at age 18 to college they gained weight and ate terribly which affected their immune system but thankfully they are now getting back to what they learned while living at home. Our diet was basically like this: Monday-Friday we will have no breakfast, no snacks and eat a healthy lunch and a big heathy dinner and during the weekends we will have a big breakfast and a dinner and skip lunch. Great information in this channel! Love it 188 TimBo TimBo 4 months ago Dr. Sinclair is awesome. Besides all of the work he does, he takes the time to share it with the world🙏 48 Sean McCool Sean McCool 5 months ago First time listening to and watching Dr. Sinclair, and I really like his down to earth, not dogmatic, approach to all this stuff. Love how he is willing to admit that he still loves meat and is not all that motivated. Very refreshing. 74 Livia the Malazan potato noob Livia the Malazan potato noob 5 months ago I listened to this a second time and took notes, so I can understand the mechanisms better, and so I can create for myself a more visual representation of it all. Thank you for this podcast! 76 Andalee Hyatt : The Last Pigment Andalee Hyatt : The Last Pigment 4 months ago That was a fantastic episode. I really enjoy your content. Thank you for putting this information out into the universe so that more people can learn. 9 Wasim Ahmad Wasim Ahmad 5 months ago I am a biology teacher. I have used many of these protocols on myself. It blows my mind to listen to the scientific research that is going on in this regard. I would definitely share this info with my students. Great work Dr Sinclair. Hats off 1K Robert Donovan Robert Donovan 1 month ago When I started intermittent fasting, three weeks ago. I decided I'd be able to do the 8:16 approach, and a bunch of friends and I all started trying this at the same time(mutual support). Unlike my friends, I assumed I was in for a rough three or four days as I got used to the hunger periods. I was right. I got headaches, had very low energy, and honestly felt a little sick at times the first day. Fortunately I started at the beginning of 2 days off from work, so I wrote off that first day. By the second day, I felt a good bit better, though still was bothered by the hunger pangs. By the third day, I felt "normal" and have felt less and less hungry, even though I was not eating as many calories. I have also been eating better without really trying. Don't know if that's a benefit of fasting or I'm just paying more attention than I used to. Now I am eating far less than I used to and not feeling at all hungry until just before feeding time. 2 Rosemarie Rosemarie 2 months ago Love the podcast. Very exciting about the Mediterranean diet being the best for longevity. I grew up eating that way[ being European) now I’m doing a 14-16 hour intermitting fasting and hoping to add 30% to my life span. I’m 66 years young 😀 8 Sarah Pellett Sarah Pellett 5 months ago Thank you so much for sharing all of this information on what a proper, healthy, life saving diet should consist of. I eat up (no pun intended haha) all the info. I can on diet and nutrition, however there is so much contradiction between the different popular diets out there and what’s trending this week that it’s super confusing and frustrating and easy to just give up. I’m grateful for your knowledge and expertise. I’m intrigued with all you’ve shared and excited for what the future holds for each one of us. 9 AmericanEagleInvest AmericanEagleInvest 5 months ago Awesome content David! Thank you so much for sharing your up to date and powerful information to us laymen. Is there any way to get a transcript of the podcasts? 4 Roman Rubtsov Roman Rubtsov 4 months ago Thank you for this episode and a lot of valuable information provided. I've been living like described for the last 5 months and I feel much better know. The only problem that remains is that sometimes I just need more energy that comes from bigger amount of food and I haven't figured out until now how to solve. It is not that I need junkfood at times, just bigger amounts of good foods. I am studying almost all the time and this food (along with the fluids) is a great source of energy, for with food I can manage to study all the day with short breaks, with the right approach I am evidently lesser productive. 3 SP Kelly SP Kelly 5 months ago (edited) One of the best podcasts about living a long healthy life I’ve seen. I'm 84 and wish food scientist's had found this fasting protocol years ago. I do a 24 hour fast once a week and I feel wonderful. Anyway I can see a future where obesity will be a thing of the past but sadly not in my lifetime. Good luck to all you wonderful healthy people. 101 Doctor Jack Has Your Back Doctor Jack Has Your Back 4 months ago This series is awesome! I have grown really interested in botanical health and understanding nutrition further. This just confirms what I’ve been researching. Thank you! 17 RoedhamHouseRanch RoedhamHouseRanch 4 months ago This was absolutely EXCELLENT!! At almost 62 and watching co-workers & friends who are around my age, pass away from various causes (often age related illnesses) has really alerted me to my own health and mortality. I don't want to succumb to illnesses or to die young. Nor do I want to age and be sick throughout those last years....for myself or for my family to watch me suffer. Dr Sinclair...bless you for sharing your knowledge, your insights, your recommendations and for showing us, that regardless of our stage/age in life, we can help ourselves. 😊 💞 33 Daein Kang Daein Kang 5 months ago I’ve done 7 day fasts with just liquids- water, tea, Chinese herbs cooked down- and I do exercise like swimming and biking- the first 3 days are challenging but after my body gets used to it and my hunger comes and goes quickly without being as severe plus my thoughts get very clear and I feel like I have more energy. 4 Masii Harwood Masii Harwood 4 months ago Thanks very much for such an informative and enlightening conversation, you guys are great souls ❤ ♥ 2 Cheryl R Leigh Cheryl R Leigh 5 months ago What a lovely gift to be provided these anti-aging lectures by the very brilliant Dr. David Sinclair. Would highly recommend u please share and provide this gift to others. 141 Ashley Horton Ashley Horton 1 month ago Thank you so much for these videos! I really appreciate educators, scientists, and doctors that make their knowledge accessible to the general population. The science you present has changed my life. 1 Wei Geng Wei Geng 5 months ago Such amazing and useful information not for longevity but for healthy longevity. Thank you so much for your work. 2 Leonardo Paredes Leonardo Paredes 3 months ago I have been doing what this guy says for the past 3 years + without even knowing about his existence, found him out in Andrew Hubberman's podcast. I eat once a day (giving at least 16 hrs of fast) and fast once a week 24 hrs and sometimes for longer. I used to be always sick and tired all the time since kid. It's been 3 years + I don't get sick, I did a full blood and hormonal pack exam test and all my stats are on the optimal spectrum, my testosterone is at its peak and I feel great, full of energy and mind clear. I'm basically watching his videos and learning more + confirming what I discovered by trial and error by myself and I trust 100% this man is correct. I'll die fasting, restricting calories and avoid processed shit. There are entire industries draining people's mental and physical health but thankfully I got out of this and we have blessed people like this guy to come out and publicly provide the population with this life changing knowledge. Success for you Dr. David. 13 Captain687 Captain687 2 months ago I can confirm through my experience that fasting feels amazing once your body gets over and eventually overcomes hunger pains. 1 John Hall John Hall 5 months ago Loved your book and finding these podcasts are just adding a higher level of detail which is great, I am sharing with friends and family as well 1 noonecaresaboutgoogle+ noonecaresaboutgoogle+ 5 months ago I've always bounced in and out of exercising and eating well, taking my relatively healthy body for granted. Dr Sinclair's very easy to understand advice has given me the motivation to make permanent healthier habits for nutrition and lifestyle. Delaying aging by 8 or 10 years was the motivation I needed! 34 Ajith Samaratunga Ajith Samaratunga 4 months ago Thank you Both explaining for all of us . Both of you are excellent teachers . Most rational scientific discussion. 1 Shelley Boa Shelley Boa 5 months ago So happy you have created a youtube channel David!! Such an amazing gift to share. I went plant based about three years ago, then I kind of fell into IF. I found it easy to go to 16/8 but now I am 20/4. Thank god, working from home now, its kept pandemic weight off. Im almost 60. I lost my meno weight, leaned out and maintain my muscle mass by doing regular Ashtanga. still doing dropbacks and handstands. brain fog gone, IBS gone. also no more jet lag from long flights. I really get an instant feedback loop on what causes inflammation in my body, and when I avoid those foods, I feel immortal most days, like I used to in my twenties. its all amazing except my sleep. that is still a crap shoot. 50 Cosmos-smallpiece Cosmos-smallpiece 5 months ago I really thought Matt guided this podcast extremely well and his questions and interjections were excellent . I recommended that everyone watches this . Great presentation 7 Som Som 5 months ago What a great talk. Love how informative it is, and at the same time how easy it is to listen to and understand. Thanks guys 4 Aneesha Anand Aneesha Anand 5 months ago (edited) Excellent content, many thanks for sharing your expertise and knowledge with the world! I personally think this conversation style episodes between Matt and yourself work very well, both in terms of spot-on probing further, whether to get you to elucidate or elaborate, and/or in terms of the dynamic and both your energies. 6 Sandra Determan Sandra Determan 5 months ago Absolutely amazing, as always! David Sinclair is a genius, and he's literally changing our species for the better. So grateful 131 Attila Mészáros Attila Mészáros 3 months ago Great episode indeed!! I have a question related to the time restricted fasting: It absolutely makes sense why skipping just lunch isn`t the best idea because one cannot reach 16 hours of fasting like that. Although I was wondering whether is there any difference between not eating breakfast and have lunch and dinner or have breakfast and lunch but skip dinner? Thanks in advance for the answer! 2 Ali Saber Ali Saber 3 months ago I am taking notes of everything you describe here. your words are really helpful. I wish everybody were excited to watch these episodes and take advantage of your words. As a geneticist I would love to work in your research team one day. Keith Kerns Keith Kerns 4 months ago Your program is awesome! I learn so much. Please continue the series. Suggestion: can you do a segment on serrapeptase? It’s supposed to remove plaque from arteries, and dissolve dead cells, scar tissue, blood clots. There’s a debate if it survives stomach digestion. I read a 1994 Japanese study summary that indicated it did make it into the intestines for absorption. With all your knowledge and expertise, would love to hear you delve into its efficacy. Thank you very much! Cody Born Cody Born 5 months ago First of all, thank you for all of the great, digestible content. I hope you get some fulfillment from helping the many people who are able to improve their lives from your research and videos. Although there is a lot of overlap, it seems that there's a natural opposition between muscle building and longevity. Personally, I prioritize longevity over muscle gain and maintenance, but I also don't want to sacrifice where I don't need to. From my naïve understanding, it seems that compromise could be found by either altering days of focus (ex. 4 days calorie restriction, 3 days high protein) or my consistent moderation (everyday moderate protein intake & intermittent fasting). Is there any research that you're aware of that shows evidence one way or the other? 4 Steven A. Bergg C-21 Executives Steven A. Bergg C-21 Executives 3 months ago When I first asked my friend who got me into fasting about being hungry, he said hunger is a feeling you can get comfortable with it. 1 Erik Lindblad Erik Lindblad 5 months ago Hi David! Great episode! I've been doing 16/8 fasting since 2009 but is doing 18/6 since I started following you. I am also a glaucoma suspect and your research has given me so much hope and less worrying. I have two questions: 1. Meat is just slightly higher in BCAA per 100 gram of protein than, fish, chicken, low-fat cottage cheese and whey. Even soy, lentils and quinoa are almost as high in BCAA. Would eating a more plant-based diet still be beneficial if BCAA is still high? I need to get my protein from somewhere. I am an amateur weightlifter but also care about longevity. 2. You mentioned limit fructose. What about whole fruits? I eat a lot of both fruit and green leafy veggies. Thanks! 52 disease /health /diets disease /health /diets 5 months ago Thanks!! Dr. David sinclair giving to us good information about human being aging..amazing episodes.. 1 nietylkodupamnieboli nietylkodupamnieboli 4 months ago It started when I realised I cannot provide enough calories for my longer bicycle rides I got in love with and I always struggled with bonking. Then I found out about ketones as an alternative fuel and about fat/glucose metabolics to know how does it work. Even before getting enough of knowledge I strated experimenting on myself and it was hard and uneffective. It took me some time to find out what kind of diets or feeding lifestyle I'm most confortable with. So as for a breakfast I don't do really a breakfast when it comes to glucose & insulin components in me after night fasting, but drink a coffee with lots of fats (milk, butter, coconut oil, cocoa) and small sugar intake (lactose in milk and fructose in honey & some carbs in cocoa) before my bicycle ride (about 1h) to work. Then I fast until I finish the job or even later when I got back home. It's about 2-4 hrs feeding window, first with carbs just after the bicycle ride and then more fats then carbs before I get to sleep. This is how I work. There was a time I was trying to stick to 1 meal a day (late supper usually) and because I've exercised a lot (bicycle + swimming and some kettlebell workouts), I needed a lot of calories intake to compensate, the only way I would be able to follow the 1 meal a day rule, was to keep my food as fatty as possible just to keep it low in volume so I can sleep without feeling sick. That's how I tested ketogenic diet on myself and how to live with it. After 1 week it's easy peasy, but still requires a lot of conscious decission making about what food to eat especially when visiting someone like friends or family. So the strict ketogenic diet is not for me, but knowing when eating carbs is ok and when it makes me vulnerable to what insulin makes with my body is crucial, although i break from it on Sundays and any ocasions involving other people dear to me. The bottom line is that nothing really I have heard here was mindopening to me, so I know it has to be true. Janice Marie Singleton Janice Marie Singleton 1 month ago This was so great. Thank you so much, I have learned quite a lot of helpful information! Both the Host and the Doctor are highly intelligent and have a sense of humor. I will return next week. Joy, Peace!!! Denise Coates Denise Coates 5 months ago Thank you for sharing your vast knowledge base. Please can I ask a question. I’m post breast cancer 6 years (A hormone based breast cancer) . My post treatment is a tablet called Anastrozole snd currently I take it in the morning after some food that’s lined my stomach.. I really believe in the intermittent fasting but only skipping one meal. I do exercise and I’m adopting a plant based med diet…Is there any other advice you can give me? Thank you. Denise 🎀 4 Julieanna Walker Julieanna Walker 4 months ago I love the geek humor you guys have!!! The learning is awesome too; however, your ability to keep moving forward after a super great joke amazes me. I get derailed, but, appreciate your ability to move through it keeping on point shows respect for our time. 1 avigars97 avigars97 5 months ago It's so valuable to be learning this on the side of doing a molecular biology degree. All this knowledge and insight is greatly beneficial to my focus. Thank you! 45 Little O Little O 3 months ago My #1 rule for health is "NEVER eat after sundown." Per Dr. Satchin Panda that causes massive inflammation that doesn't get resolved until the next day. He also said that given a choice between eating bad /unhealthy food during the day or nutritious food in the evening, it is better to eat during the day because "eating late turns even nutritious food into junk." I told this to a stranger on a golf course a year ago. A month later he saw me at the golf course and told me that he had stopped eating after sundown (he overhead me talking about this with others). he said he was 73 and a LONG time Type 2 diabetic andoften taking insulin. He said he decided to change "just one thing". he confessed that he was, as before, still cheating on the diabetes diet even drinking some beer and wine on occasion. He then said that his AM glucose that morning was 78 and he "hadn't seen such a low number in a very long time." He saw a downturn of his am glucose reading within the first week. And that's all he had changed. Another man that I know of, was morbidly obese (nearly 300 lbs) and out of desperation he decided to never eat after 6PM. he didn't know of the above but was frustrated that he had no self-control. He also decided to drink more water and he started to crave it. He lost almost one-third of his body weight in 12 months with just these two changes. And he confessed that he was still eating his favorite snack: donuts. True story from an old man who turned his health around with time-restricted eating, intermittent fasting, a few multi-day fasts and "NEver eating after sundown." 6 David Banks David Banks 1 month ago Very interesting. Thank you for making this available on YouTube. There is one thing that remains hazy to me, it's the recommended daily calorie intake. Your body has to "feel" hungry , but you still have to provide it with the necessary calories (whenever you choose to take them) to go through 24 hours and meet your energy needs. Surely you don't want to go below your BMR. So, how do you calculate this intake? Also, by reducing the number of meals to only one, you make it more difficult to cram into this unique meal all the variety of vitamins, minerals etc... you body requires, and you have to take supplements - as you do, in the mornings. You become highly dependent on these supplements. What happens if you suddenly don't have access to them, for a prolonged period of time? Do you revert to more meals per day , and does you body remember how to "extract" those elements from actual food? Take care 1 Katongo E. Nunkwe Katongo E. Nunkwe 5 months ago Your good work is appreciated and that you have shared is really great. I needed to hear this and it has come at a time that I am learning to quit sugar. Very thankful for this information. 2 Brenda Steele Brenda Steele 4 months ago LOVE this podcast. Please continue! Christine Lutzko Christine Lutzko 4 months ago Great episode, super informative. Can you consume bone broth while fasting (between meals)? Leyla Herr Leyla Herr 5 months ago Love your information. I have been eating 2 meals a day for 6 months, no snacks, no sugar, minimal startchy carbs. Love it. I work hard to keep my children at an absolute minimal sugar intake and junk and processed food. Can you speak more about what would be good for our children in regards to fasting or just in general what kind of food timing and regiment would be healthier for them? Would love an episode on childrens nutrition. 118 MagnetCrusher MagnetCrusher 2 months ago (edited) I went from eating all day to doing two 48 hour fasts and then eased into OMAD and found my body agreeing to letting me do OMAD as a compromise, I was actually going to do 48s for a while. I was desperate to get myself out of the all day eating style. I'm the type of person who has difficulty with "easing into it" and I find it easier to just jump in and over do it at first then pull back. Every once in a while I have to do the 48s again to remind my body of the fact that I can make it worse for it. I started doing this because it makes me feel better, I don't concern myself with the health, longevity or autophagy or anything else. When I'm eating all day like normal I develop a lot of difficulty with pain, inflammation and getting excessively sore after a short hike or workout but with fasting my body starts to function right, I can hike up mountains and repair and do it again the next day. I can hike up 2500 feet of vertical gain on a mountain while fasting, but I have to hike slower. As far as meat and vegan diet, we can see that long term vegan diets cause many problems, tooth decay, mental disorders, wasting away. I think that cycling meats is the best method or in other words if you consider all low glucose/fructose plant food as non-food then you are essentially fasting for 3-4 days then eating real food (meat) and if you are trying to not lose weight you add in the plant based food in between but if you are more strong minded and want to lose weight you just fast in between steaks. Just space out the steaks. You can try every 4 days or every 7 days, whatever works best. Vegan diet will eventually accelerate aging from extreme malnutrition. 5 Sheri Palmer Sheri Palmer 5 months ago Love David. Simple and straightforward. The West House The West House 5 months ago I enjoy the podcast a lot and have read and listened to some of David's other work. Super exiting stuff. One thing that bugs me is that most of the services and devices used (including those of the sponsors) are not available in many countries. I live in Southern Africa. Not only are most of the services/devices not available, the ones that are available are also extremely expensive due to the exchange rates of the Rand/Namibian Dollar/Pula to the USD. This is where this episode shines, because these are steps all people can take without increased expenses. With wider adoption I hope tech supporting healthier living becomes available all across the globe soon. Goddess Oworu Goddess Oworu 5 months ago ♥︎Thank you for sharing this information; following your research for about 2 years now. Been on a vegan plant based eating since 2011 + I know that a vegan plant based eating of high nutritional foods can & will rejuvenate the body - clean chemical free lifestyle as well ☽☆☾ Just Know there are lists of plants that kill cancer cells however there is not 1 animal flesh that can do the same 👁‍🗨 5 E A E A 5 months ago (edited) Hi Dr. Sinclair, In Dr. Longo's book 'The Longevity Diet', on page 64, he mentioned that 'shorter eating window (of ten hours or less)....may increase the risk of developing gallstones..' I am interested in knowing your opinions based on your research. Dr. Longo and you are both eminent researchers in the areas and I highly valued the information that you both have shared with the public. Thanks a lot for the doing the podcast. Edina M Edina M 5 months ago Great tips! I actually love intermittent fasting, before starting I remember I had a few days when I ate very low in sugar, then I started eating only once or twice a day, usually between 3pm-8pm. There are very few days when I actually feel hunger. Also, focusing on anything is so much easier. 126 Simran Bali Simran Bali 4 months ago (edited) Thanks for sharing science based knowledge! I have been reading mixed information regarding fasting impacts on women. Especially if this may disturb women hormones. Do you have any information on the best protocol for women? Marty Costello Marty Costello 4 months ago Please cover when to workout during the Fasting window and when to feed following exercise. For your upcoming Sauna, Cold, exercise, show, please cover when is it best to exercise before cold, or heat or after? Any relationship with Heat Shock proteins, fasting, exercise, feeding and timing? Thank you! Great talk and questions! 3 KetoBalans KetoBalans 4 months ago This information is incredible! I'm going to binge watch everything. all of it! Thank you! 1 Tim Crowley Tim Crowley 5 months ago Thank you for the valuable conversation. Less is best, quality over quantity. Chris G Chris G 4 months ago I have cut sugar, and can eat less now without crazy cravings hijacking my life! I am mostly eating vegan, and have upped my organic vegetable intake. I feel so much better, and have dropped 10 pounds so far. I read your book, but this format was easier to glean info from. TY 1 Pablo OlFe Pablo OlFe 5 months ago It seems that in order to improve our health and longevity we need to put our body at the mercy of adversity regularly. Thanks for your outstanding insights!!!! 61 Franck Franck 4 months ago (edited) Thanks for podcast series. You mentioned “high protein intake”, could you please define what “high protein“ means for you? How much is “high”? Many thanks 🙏 Maria Eugenia Jimenez Maria Eugenia Jimenez 4 months ago Love, love, love this episode! So much information! Hiten Patel Hiten Patel 2 months ago Really interesting, thanks Dr. Sinclair. How would couple lean muscle building with fasting in the way you advocate? I eat very little red meat, but lots of chicken, fish and veg. 1 Angus Henderson Angus Henderson 4 months ago Hi David, Thanks so much for the great series. I'm workign towards only eating once a day, but often eat fruit as a low cal, high-fibre lunch. I know some fruit like grapes are high fructose, but would shed more light on eating different fruits and their effect on fasting and ageing, please? Jessica Greg Jessica Greg 3 months ago Love watching you guys! I've been a vegetarian since '75, I'm 51yo, glad to see the science behind the morality 2 Billie Mann Billie Mann 5 months ago Thank you for finally making things clear as the title is, for the average non scientist humans. What list can we take to the vitamin store and what list to the grocery store and the times to take them. Which vitamins have to be taken with other vitamins and/or fatty food etc. Thank you so much to both of you. Thank you David for bringing Mathew LaPlante onboard to ask the questions that normal people ask and doesn't back down until he has an answer that the normal person can take to the store with them or just use at home. Thanks guys. 64 Audj943 Audj943 3 months ago Subscribed! Great information David…..and great channel; thank you for creating it! Keep spreading your knowledge; and we’ll keep listening! ✌🏻🤍 obiora onunkwo obiora onunkwo 1 month ago Thank you so much, senor Sinclair. You really advance the cause of humanity in a meaningful way! Melissa Melissa 5 months ago Hi, I am loving these podcasts however I'm just wondering about prevention of sarcopenia with emphasis on a lower protein intake. It can be a major killer for the elderly. Can you live longer and maintain muscle mass or does a decision have to be made between the two? Kind regards 1 Your Demigod was a Foreigner Your Demigod was a Foreigner 3 months ago (edited) I lost 40 pounds just by getting out of the house at 8 a.m. three times a week and not eating until I got home at 4 p.m. It was expensive, because I found myself shopping, but when I got home, I ate no sugar, didn’t even eat a slice of bread for 6 months. Unfortunately, I lived in an orchard region, and when peach season started, my weight loss halted. After peach season was over, it started again. Also, My mom was French. She lived until 94, never got above 128 pounds (5’3”), usually stayed at 117. She taught us that the growl of an empty stomach was a good thing for our figures. 3 Jenny K Jenny K 4 months ago (edited) Very useful and informative content! What is your stance on Myo-Inositol vs Metformin in combination with time-restricted eating? Tea La Ree Tea La Ree 5 months ago (edited) I had been working graveyard shifts for 5 years so I ate differently then went back to a day schedule that was sedentary due to an injury. To say the least my body gained so much weight due to sleep eating and not being able to exercise like I used to. Thank you for the info. It's been hard trying to get back to a beneficial eating pattern! 51 Jamie Yu Jamie Yu 3 weeks ago Hello this is really awesome content, thank you. Question on avoiding high protein that triggers mTOR, does it mean adding protein powder to our diet could be working against us than for us? Laura Angelides Laura Angelides 3 months ago Love your book and greatly appreciate your podcast! DaUkly Rican DaUkly Rican 3 months ago The routine and supplement David Sinclair uses is definitely working! I've been flowing him for years and he looks about 10 years younger than he was when I saw him the very first time. Blasina Vieras Blasina Vieras 4 months ago thanks a lot for this episode. I've been following your work since Joe Rogan's podcast! Keep it going 1 djslate djslate 5 months ago Love and appreciation the information. Since it wasn't really discussed in the podcast, I'm curious about your current diet. What are some example dinners you have? Approximately how many calories are you intaking? Maalti Sharma Maalti Sharma 5 months ago (edited) Key takeaways: • Cut-off artificial sugars (processed carbohydrates) • Cut-off meat or atleast start reducing it from your diet. Meat lovers can switch to Mediterranean or Okinawan diet models. • Practice intermittent fasting. Start with skipping breakfast and try to avoid snaking in between. Tip 1- if its harder for you to practice I.F. then start drinking warm water, black coffee or green tea. Tip 2- if its still hard then consume a handful of nuts (as they contain proteins and healthy fats) and wait for 20 minutes. Tip 3- You can try natural sweeteners like stevia. • Consume more colored vegetables and fruits. Go for organic if possible. • Meal order- Consume proteins and vegetables first. • Start doing strength training and walking • For longevity, vegetarian and vegan diets are the best. 305 Kevin Kiffe Kevin Kiffe 4 weeks ago Thank you, guys!! Keep up the great work that you are doing!!! Academiclibrary Academiclibrary 3 months ago Awesome content David! Thank you so much for sharing your up to date and powerful information to us David Sinclair - Cracking & reversing the aging clock - Frontiers Forum 2019 535,120 viewsJun 21, 2019 Frontiers 32.3K subscribers Renowned longevity researcher David Sinclair believes aging is not inevitable but a treatable condition. In his talk at the Frontiers Forum 2019, he explained why we age – and how we can reverse aging to extend human healthspan and lifespan. David Sinclair is Professor in the Department of Genetics, Blavatnik Institute and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard Medical School. The Frontiers Forum is held in Montreux, Switzerland. See all speakers: https://forum.frontiersin.org Featured playlist 29 videos Frontiers Forum Frontiers 580 Comments rongmaw lin Add a comment... Fizzedup Slade Fizzedup Slade 2 years ago Great speech. What an inspiration he is and all those involved in this work. 5 Karim Karim 2 years ago (edited) Fascinating! I am following Prof. Sinclairs advancements closely 👌 28 Carl Hopkinson Carl Hopkinson 2 years ago Wow, someone under 60 that actually sees value in older people. Amazing!! 129 John m John m 2 years ago Thanks doctor you’re doing a great humanitarian job for the improvement of mankind and history will remember you and generations to come will be greatly for your efforts 11 Andrew Haze Andrew Haze 2 years ago This is great information. I am a student of health and fitness. At 71 I feel great. 28 T's L'il Bear Shoppe T's L'il Bear Shoppe 2 years ago Excellent! Thank you for all of your hard work in this area! 5 Ramsey Pietro Nasser Ramsey Pietro Nasser 1 year ago If aging could be reversed safely and effectively, then this would be a galactic event. We can travel the stars 11 Ben Clark Ben Clark 2 years ago This is awesome! The downside is there are some corrupt people who society would not do well to have around that long. 2 Jane Lawrence Jane Lawrence 2 months ago I will be 50 on my next birthday, but many people still think I am still 30+. Very overwhelming but all thanks to NMN by vitruvin. Along with balanced diet and regular exercise, it's definitely possible to improve the quality of living and slow the aging process. 2 Wesley Wesley 2 years ago I'm not interested in dying, but for everyone who wants to die I wont try to stop you. Hopefully this anti-aging research will expand lifespans dramatically, and I am optimistic that we can simultaneously deal with the environmental and social consequences that will arise from this development :) Shem Believer Shem Believer 2 years ago Can't wait to start his book Lifespan! Thank you Dr Sinclair. Yes I want to live on this Earth a purposeful healthy productive life as long as God has chosen for me. I didn't get to decide when I was born nor when I'll die. No epigenetics can protect me from the angel of death and my final breath. Personally I would not wish to stretch over 90/100 even in the healthiest state, that is more than enough of this very ephemeral life lol so unfortunately the science doesn't take into account spiritual dimension. Achieve 200 or more years for what purpose exactly? And will Earth be a better place to live in? 7 thatwasprettyneat thatwasprettyneat 2 years ago i guess this might sound naive to people, but this man gives me hope. also, i think what he's talking about is not fanciful--it's only fanciful in the context of a history without the knowledge that we have today. aging is inevitable, but the deterioration of the body may be fungible, or even negotiable. the challenge would be to figure out how to structure society if and when that happens. 8 Benjamin Martinez jr Benjamin Martinez jr 3 months ago Love this guy ,. I'm trying to figure out why I still look how I did twenty years ago ..I just turned 41 John Wendland John Wendland 2 years ago Followed Sinxlair for years...he never told anyone what he was taking until recently...he must be on the cusp of a breakthrough that will make what he has been doing moot 21 Lazarus Blackwell Lazarus Blackwell 1 year ago We can all make life so much better Why should we accept anything as the "way of things"? There is no reason for that. Accepting disease as something normal is just a poor excuse for not wanting to work to solve that problem You don't have to work Just keep a positive mind and show some gratitude for those who make lives better 4 Hector Cabeza Hector Cabeza 2 years ago Great video, thank you for the information and the hope 5 BK BK 2 years ago MY EXPERIENCE I was doubtful but desperate and this is what happened to me and totally unexpected. I stared doing intermittent fasting by skipping breakfast. I got on PQQ20mg, resveratrol, NR 250mg, Cycloastragenol 25mg on a empty stomach first thing in the morning. After about six weeks I noticed I could not sleep for more than 7 hours and thought this was interfering with sleeping BUT I realized my body no longer required to sleep longer and I could work all day into the evening without any fatigue Like I used to when I was younger. Loose skin under my neck started to tighten and also on my face which was a surprise. My eyes started focusing much better on small print. When I go for a light jog I know I can push much farther than before where I usually run and walk intermittently. My balance has improved where I can walk on a beam instead of falling off. I started dreaming almost every night very intensely. My male body is doing weird things that I haven’t experienced since I was 18. All I can say is something is happening that has never happened before with anything else and I have not changed anything. I eat very healthy organic non-treated food and I don’t eat junk but the change has to be because of this because that’s all I have done different and if this is only the beginning I am looking forward to 3 months supply I can’t what to see what happens but this is my experience which I am did not expect or plan for because nothing else has done anything but my energy was gone and I was getting weaker and felt wobbly and health slipping away. I was good till I hit 60 and then started noticing a change downhill and that’s happened to everyone in my family. I saw that early so I made changes at a very young age and it still came on no matter what I did until I tried this. Things that matter. Get the pesticides/roundup and chemicals out of your food, get the weight down by replacing junk food with natural food your body can recognize, drink pure clean water filtered, Lower high carbs and sugars, do a light jog every day. When you get desperate enough and scared you will be willing to try this like I did and hope your results will be the same before it gets too late. I don’t know if it’s the combination I’m taking and the way I’m taking it or what but it may have something to do with increasing the speed and effect I am having. 63 Juan Carlos Gutierrez Betancur Juan Carlos Gutierrez Betancur 3 years ago Excellent as always! 5 Philip King Philip King 2 years ago I've gotten excellent results with Nicotinamide riboside 450 mg per day,300 mg in the morning, no breakfast.150 mg with lunch, my energy level and stamina are 100% better,my eyesight has improved dramatically, mental focus is 100%. I'm 51 ,construction worker,and can only verify what has worked for me.I hope everyone gets the results I have,the difference is amazing. 105 Janika Mahmud Janika Mahmud 2 years ago astonished how can people dislike it! anyways very thoughtful indeed. need to skip a meal, especially at night and definitely would try to fast at least two days a week. Old Guy Old Guy 2 years ago If you watch his older videos (10 years ago) on the internet, you don’t see him get old at all. 11 michael Scaturro michael Scaturro 2 years ago that's brilliant, equating concepts of communication theory to biology. Wow. 9 Anna Redelinghuys Anna Redelinghuys 2 years ago David, i am really thankful for all your time and effort. Thanks again .. I would like to know if my husband can be helped he is going blind and it is so sad to see because he is such an active man . He is a diabetic and it has attached his eyes he has gone blind in the right eye and has about 30% vision in the left ..I would like to surprise him with a possible cure 1 Vitruvius Vitruvius 2 years ago This guy is coming out with a book in 2020..Definitely going to read it. 9 Rick Murie Rick Murie 2 years ago Wow. Perhaps I speak for many when say I'm not nearly so afraid of dying as of the possible ravages of old age leading to death. 18 Drale L Drale L 2 years ago From childhood I always said I would Live forever, or die trying. Now I see vindication over the horizon to all who were laughing at me. I did take the quote form somewhere though I can't remember where. 5 Curt Zimmerman Curt Zimmerman 1 year ago I have been taking nmn,1 gram a day for about 3 months now. Also taking reservatol. Can’t really say I see a difference but will probably give it another 3 months. At about $130 a month I hope to see a difference to continue. 1 Patrick van meter Patrick van meter 2 years ago Help everyone to see climate change take us all out. That said, I like this just in case. Lifespan, fascinating read. Fina Khan Fina Khan 2 years ago There is German technology that introduces frequencies, vibration and resonance because it’s the language and key to longevity. •HermHerm• •HermHerm• 2 years ago I have been taking NMN and Pterostilbene for 5 months and feel great. Arthritis almost gone. More energy quicker recovery sharper mind. Family and friends also the same. I’m 54. My 83 year old dad now does 50-60 pushups a day and can work outside 6-9 hours. Huge improvement. And both out cholesterol have improved. 20 John Travolta John Travolta 2 years ago I'm 27 years old and I'm really interested in talks about aging. I think we humans have now bigger activiments and so to have a chance to active those goals we must live longer. 4 Danni Phillips Danni Phillips 2 years ago I am 65 - I run 5k almost every day, I do a weight routine, martial arts and this year I have returned to playing baseball 40 rutr wer rutr wer 3 years ago this guy is close to 51 what ever he takes i want it. 295 Eifion Phillips Eifion Phillips 2 years ago It's all down to collagen too and sugar reduces collagen so take collagen capsules, cut out sugar and derma rollers are amazing for bringing new cells to the skin reducing wrinkles, lines and sagging skin! 1 Jack Roth Jack Roth 2 years ago (edited) Dr. Sinclair, Sir, please, let's get this show on the road. I'm 75 and I damned sure do not want to be the last human to ever die. In the future mankind will look back on the time when we all had to die at some time. I'm running out of time. I have a good life and I want it to continue. Also, I am busy, I don't have time for death. So sir, please let's get this thing going. 15 Klaus Zoidberg Klaus Zoidberg 2 years ago what happens when you take NMN for a year and then you interrupt the intake for 2 months or so? Does anyone know this? 6 bluejackscanada bluejackscanada 2 years ago He looks like a healthy 50 year old, he is not fat and likely has good genes to start with. I applaud his effort to actually reduce biological age. I hope he can reverse aging, its terrible. If it were not, cosmetic companies would be looking for the fountain of aging. Women of God Women of God 2 years ago ☝️☝️☝️❤️❤️❤️❤️thank you for your information Carmen Tongson Carmen Tongson 2 years ago Wow he looks so young....amazing....looks like he's only in his mid 30's! 1 One Sun One Sun 2 years ago Listened to the whole thing because he looked young at 50. 42 krm398 krm398 2 years ago my question would be..at what cost? can normal working..or retired people afford such a thing? or will it be so costly that only Bill Murray or someone like him can benefit? 3 Irina Andrea Irina Andrea 2 years ago Wow ! He talks the walk ! If he really is 50 but looks 30 then I am a believer 1 GO GREEN GO GREEN 2 years ago Causes of aging: 1. Mitochondrial dysfunction. 2. Telomere shortening 3. Epigenetic changes 4. Mutations. 5. Aggregation of proteins. 6. Glycation. 7. Oxidative stress. 8. Enviromental factors. 144 Husham Ahmed Husham Ahmed 2 years ago روووعة هذه ستكون ثوره في تاريخ البشريه 2 Fauzia rahman Fauzia rahman 1 year ago I am waiting for this.i hope it comes in my lifetime. 5 Pugger 653 Pugger 653 2 years ago I understand that over a very long period of time you brain will become overloaded with information. So that would make living for eternity impossible. But I also have these “theories” where you can come up with some method to have self induced amnesia on memories that are deemed unnecessary such as a former relationship that didn’t work out. Or even death of family members so you don’t need to have the pain of the loss. Maybe far enough in the future we gain the capability to transfer are consciousness into some software and then gain the capability to store memories that we don’t need at the moment, so we can draw upon the memory’s when we need them. Then again these are just some things I thought up after listening to this video. This video had me thinking for a good half an hour over possible futures. William Fields William Fields 3 years ago If Nmn can improve life of yeast, i would assume that it can improve the function or life of bacteria as well. iI that’s the case what are the long term effects of helping bacteria like helicobacter pylori (H. pylori)? or other Bacteria that can cause things like, Coronary artery disease? Our water in Florida, has this flesh eating bacteria called Vibrio. Most people can fight it off, but if I’m taking this…..Am i helping any of those bacteria to further spread?. 11 Nubian King Nubian King 2 years ago What really work to turn back time...david... James Humphrey James Humphrey 2 years ago this combined with Neuralnet and there may be some hope for the human race 22 Ivan Break Ivan Break 2 years ago he doesn't look older since his first ted talk Christina M Christina M 2 years ago This guy looks incredible for 50. 81 Cindy Radison Cindy Radison 2 months ago Honestly, I just don't want to be a wrinkly grey-haired useless woman who can’t remember stuff in my ripe age. If I can get older and be able to sustain my body slowing down aging or even biologically reverse aging to my prime, that is ideal. Obviously, nobody can live forever, but I feel like we can live a lot longer, so why not slow our age rather than age slowing us down? This is why I am constantly taking Dr. Sinclair’s NMN, a NAD booster and indeed a health provider. With NMN Vitruvin Nutrition (500mg) a day every morning with protein drink and Greek yogurt, it has radically changed everything. All sorts of problems have disappeared. Now, age is just a number. 2 Women of God Women of God 2 years ago I would love to reach 120 why not if God allows me to live the long My grandpa is 100 years old and he still here with us 5 Glenn Thorn Glenn Thorn 2 years ago Great work David on your work ,Please can you focus on, affordability and access . why educate when these subs are for the privileged few 1 Grox44 Grox44 2 years ago I wish I could afford NMN. I think there is evidence showing it works. Wish I could at least try it for a year. 5 Robert T Robert T 2 years ago His "vision" of what is coming is pretty mealy mouthed. Is it virtual antiaging, or is it not? I'm all in for that. But he keeps hedging what he thinks is possible. Chris Hax Chris Hax 2 years ago Since I was young I have fasted and eat one larger meal a day usually and have always thought it helped my body's metabolism remain slower than others and now it's becoming accepted as healthy. My ego is being overfed now :) 11 bogrunberger bogrunberger 2 years ago So you'll have to work even longer, great! But seriously there are several issues with this, over population perhaps being the most important one. But another one is that assholes will also live longer and get more experienced. Evaristo Grant Evaristo Grant 2 years ago Only thing is that the average age of death is the same as it was more than two thousand years ago. 3 score and 10 (70). Upon searching Google it gave 71.5. Hmmm. How are we really living longer? burritos burritos 2 years ago I do intermittent fasting. It's cheaper than medications. 109 Sydney Hamilton Sydney Hamilton 2 years ago Make eternal youth happen to both humans and animals! 5 Anita Carrier Anita Carrier 1 year ago Metformin? All pharmaceuticals are acidic, this causes inflamation. Aging in my view is about free radicals which cause oxidative stress, free radicals are unstable molecules because they are missing essential electrons, therefore they scavenge electrons from cells causing them to deteriate. Excessive exercise causes oxidative stress, exercise shoukd be moderate and consistant. Antioxidants donate electrons to free radical molecules stabling it and preventing scavenging from cells. Patrick king Patrick king 2 years ago i am going to live forever, i already figured how to keep young looking inside and outside the natural way. Sheetal Kelkar Sheetal Kelkar 2 years ago People living that long is a scary idea! I appreciate my life because the fact that it’s temporary 3 Devon Mckay Devon Mckay 2 years ago Me: we all getting old David: im about to rewind this mans career 5 Madben 99 Madben 99 2 years ago I'm close to 70 and have been following his 'protocol' for at least 6 months and had high hopes based on his lectures and supposed research ( on mice). I have experienced NO benefits what so ever. He's selling snake oil, folks. He has some interesting rodent results and has spun that into a personal fortune by his lectures and startup longevity companies. 14 Vince Abbott Vince Abbott 2 years ago Let’s get real about this if you have good genetics you will look younger. I have always been told I look ten year younger then my age.Yes I do eat right and go to the gym . The thought of making it to 100 is nuts. There is no need to go that long unless you want someone to feed you and change your diaper, your quality-of-life is about zero. Jypsea Moon Jypsea Moon 2 years ago Very intriguing Erich Kiparski Erich Kiparski 2 years ago The crazy thing is that this guy’s schedule is extremely demanding/grueling and he probably looks like his version of “shit” in this video. Imagine what he looks like when he is rested and relaxed. 😳 KittyCat Land KittyCat Land 1 year ago salute doctor i need This Max Freedom Max Freedom 2 years ago "We can now help you live longer and healthier." Yep. It's called diet and exercise. 1 John John 2 years ago This is going to be the start of the zombie apocalypse! 9 carla de almeida carla de almeida 2 years ago great guy! Edilberto Rivera Edilberto Rivera 2 years ago So fasting is actually effective and healthy. Isn't that written on a 2,000 year old Bible? 7 مها الهذلي مها الهذلي 2 years ago ترجمه العربية متى تنزل؟؟ Galliano Marr Galliano Marr 2 years ago How many mg of Resveratrol does he recommend daily? IncognitoTorpedo IncognitoTorpedo 2 years ago (edited) I've got some bad news for you. Even if you get epigenetically reprogrammed to a younger age, you will not look much younger. You will be metabolically healthier, but your UV-damaged skin will not repair itself, and it's unlikely to fix adrogenic alopecia. I hope I'm wrong about this, because I have my share of damage, but I'm not holding my breath. It did repair that crushed nerve, which is promising, but that's not the same as older damage. A more relevant test would be to try to regrow an old nerve injury. A young epigenome still isn't going to know how to repair a glycated protein, or remove scar tissue. 1 MajiMarji MajiMarji 2 years ago I’d like to meet his dad! 3 martin sinclair martin sinclair 3 years ago We all now know it works. Online even every pharmaceutical company in China won't sell the powder for less than $3,000/kilo. It goes up to $5,000 depending on where you check. I can buy a kilo of cocaine in Quito for $2,000. When will the price come down to reasonable levels? Pierre Normandeau Pierre Normandeau 2 years ago Scientist easely forget that healthy living and purity of the blood and organs is also the main determening factor in staying young and living longer. That is why people who live in polluted cities live 5 years less than people who live in the country. People who are vegetarian and avoid alcohol live 5 years longer on average than meat eating people. People who exercise regularly and stay at normal weight livre 5 more years than overweight people .You should question a biologist about the benefits of fasting on water. Biologists know much more about health than any medical doctor.. Fasting on water is a universal and simple way for people or animals to purify the blood and prolong a healthy life... 4 Dee Jay Dee Jay 2 years ago This just screams design NOT evolution Longevity Coach Longevity Coach 3 years ago Insulin is not only the aging hormone, its also the hormone will be produced when we consume carbs , tea, coffee, cigarettes, bread, pasta etc. but not when we eat meat or drink water. Well 12 months ago I stop producing insulin so now I only eat meat and drink water. Thats the price to pay for health and longevity. 14 Jon skelin Jon skelin 2 years ago FoundMyFitness 426K subscribers In this episode, Rhonda explains what NAD+, why it is so important for aging and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, what animal and human data says and some concluding thoughts. NAD+ is crucial for our survival. Small amounts of it can be obtained in the diet, but the body recycles it to get most of what it needs. Unfortunately, day to day living plus normal aging can cause NAD+ levels to drop. This causes metabolic and mitochondrial dysfunction, as well as many of the other problems and conditions associated with aging like elevated DNA damage. NAD+ levels can go up when we exercise or fast, but NAD+ precursors like nicotinamide riboside and nicotinamide mononucleotide can also increase NAD+ levels in a dose-dependent manner. However, most of the data on NAD+ boosters comes from animal studies. Whether these boosters are effective – and safe – long-term in humans is still a big question. ▶︎ Get the episode's show notes, timeline, and more https://www.foundmyfitness.com/episod... Chapters 00:00:00 - Introduction 00:01:01 - Aging 00:02:47 - Overview 00:07:35 - Depletion 00:09:19 - Supplementation 00:11:26 - Animal studies 00:13:47 - Cancer 00:15:57 - Dosage 00:25:44 - Human data 00:28:25 - Storage 00:29:00 - Recap ▶︎ Detailed overview of NAD+ https://www.foundmyfitness.com/topics... ▶︎ Detailed overview of nicotinamide riboside https://www.foundmyfitness.com/topics... ▶︎ Detailed overview of nicotinamide mononucleotide https://www.foundmyfitness.com/topics... ▶︎ Did you enjoy this podcast? If you want to support me in getting more of this free information out to the public, please consider becoming an FMF premium member! In doing so, you'll also get access to exclusive member benefits, such as a private podcast feed offering early access and occasional bonus episodes, monthly live Q&As with me, a members-only library that includes presentation slides with all of the supporting figures, graphics, references, and quotes. Also included are Rhonda's private notes on topics discussed in the podcast, bi-monthly member-exclusive Science News Digest email, and more. Thank you for your consideration! Learn more here: https://www.foundmyfitness.com/premium ▶︎ Gain valuable insights by running your raw genetic data through the FoundMyFitness report https://www.foundmyfitness.com/geneti... Chapters Introduction 0:00 Aging 1:01 Overview 2:47 Depletion 7:35 Supplementation 9:19 Animal studies 11:26 Cancer 13:47 Featured playlist 31 videos Just Me FoundMyFitness 1,255 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 2 years ago (edited) 00:00:00 - Intro. 00:00:48 - Nicotinamide riboside supplementation in humans has been shown to raise NAD+ levels in white blood cells. 00:02:47 - Overview of NAD+ 00:05:12 - NAD+ plays an important role in mitigating DNA damage. 00:05:30 - Excessive DNA damage can decrease NAD+ levels by 20-30%. 00:05:42 - Lymphoblastoid cells from centenarians show increased PARP-1 activity. 00:05:55 - Between different species of mammals, higher PARP-1 activity is strongly associated with a longer lifespan. 00:06:36 - Lower organism evidence: A second copy of SIR2, a yeast sirtuin, gave rise to a 30% extension of lifespan. 00:06:43 - NAD+ is required for the activation of sirtuins, which epigenetically regulate a variety of stress response-related processes. 00:07:03 - Energy stress, such as from fasting, exercise, or caloric restriction, increase the NAD+:NADH ratio. 00:07:37 - NAD+ becomes depleted in the brain, heart, and skeletal muscle as we age. 00:08:13 - Decline in NAD+ levels have been associated with many broad categories of clinical disease such as neurodegenerative, cardiovascular, infectious, musculoskeletal. 00:08:48 - NAD+ supplementation has been shown to increase lifespan in models of aging in yeast, worms, and rodents. 00:09:48 - In contrast to de novo synthesis, the predominant source of NAD+ in the body is via the salvage pathway, which is subject to feedback inhibition by nicotinamide. 00:11:56 - Animal studies have shown nicotinamide riboside supplementation is able to increase insulin sensitivity, increase endurance and strength, reverse mitochondrial damage, increase mitochondrial biogenesis, and reverse muscular atrophy. 00:12:30 - Nicotinamide riboside has shown positive effects on the brain in animal, such as increased neurogenesis, decreased cognitive deterioration, decreased amyloid-beta production, and increased synaptic plasticity. 00:12:50 - Nicotinamide mononucleotide has been shown in animals to counter an obesogenic diet, improve markers of metabolic health, improve heart function, and improve cognition and memory. 00:13:10 - A 12-month dietary study of nicotinamide mononucleotide suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies in mice. 00:13:47 - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice. 00:15:57 - Plausibility of dosing: comparing animal and human doses. 00:18:05 - Tissue-specific metabolism and bioavailability of NR and NMN. 00:24:32 - Oral administration of NAD produces NR and NMN in the intestine. 00:24:19 - Intravenous administration of NAD, rather than its precursors, shows interesting results: an increase of NAD content and sirtuin expression in the hypothalamic region of the brain. 00:26:15 - Human study #1: 250mg of NR + 50 mg pterostilbene increased blood NAD+ levels by 40%, while a double dose (500 mg NR + 100 mg pterostilbene) increased blood NAD+ levels by 90%. Additionally, there was a decrease in blood pressure, and ALT (a marker for liver health). 00:27:12 - Human study #2: 500mg NR twice daily for six weeks increased NAD+ levels in white blood cells by 60%. 00:29:08 - Concluding thoughts and recap. 252 pablopolski pablopolski 2 years ago Concise, comprehensive, and articulate. I don't even need to speed it up to get through the information. Well done. 373 FoundMyFitness DAVID EVANS DAVID EVANS 2 years ago (edited) Rarely do we find in the study of nutrition, detail like presented in this video, yet at the same time Rhonda is able to get to her final conclusion without leaving everyone in the weeds. Extremely well done. Combined with Dr. Nicholas Pericone and Dr. Jason Fung, we are starting to get a handle on what is necessary to make critical changes in our life for optimal health... 7 Chuck A Chuck A 2 years ago Congratulations Rhonda you have smashed the record for total mentions of "Nicotinamide and Nicotinamide Mononucleotide" without stuttering, giggling or entering a comatose state. Kudos! 183 Chris Benton Chris Benton 2 years ago Excellent lecture, well put together, a good balance of pros and cons, useful diagrams and a clear summary at the end. Perfect presentation technique. 111 FoundMyFitness Cat Man Cat Man 1 year ago I've been taking a low doseage of NMN for a couple of weeks now. I started with 100mg in the morning and 50mg at night on the first day, then 50mg the next morning. I hadn't been expecting any results for at least a week or so. About 2 hours after taking that second morning dose I went out shopping and was astonished to find my legs wanting to walk faster and faster, as if under their own volition. I've not walked like that in almost 7 years. I've had a number of strokes and suffer numerous symptoms, manly to do with inhibitted activity levels. My mind is foggy most of the time and the NMN has not done anything for that, but I certainly feel the difference in energy levels, it's really amazing. I also found that after a few days I had to stop the NMN for a couple of days as it seemed to be making me feel more groggy, so I now take it 2 days on, 2 days off. The brand I'm using is an American Brand called RevGenetics, and it's called Advanced NMN, in capsule form. I know it's also available in powder form too. It's quite expensive even in capsule form and would cost the earth to take it regularly at the doseages recommended in this video, but I can assure anyone that the effects at the doseage I am on are truly amazing. 4 Rich Rozmarn Rich Rozmarn 2 years ago Great presentation, thank you so much. I take NAD with R-Lipoic acid, D-Ribose and Resveratrol for a pre workout. I work out 3-4 times a week and feel as good as when i was 40, now 60. 51 Scott Joshua Scott Joshua 2 years ago What a herculean effort and a testament to your ability to grind it out for hours on end. You’re incredible Rhonda. 15 FoundMyFitness No Limit No Limit 2 years ago A very professional very well presented lecture . English is my 4th. language and I did not have any real problem to understand it and learn from it. Doc, I really appreciate your effort to create this video. Thank you. 7 FoundMyFitness Tony Westbrook Tony Westbrook 2 years ago I learn so much here by your presentation and documentation. Thank you Rhonda for taking, what must be a lot of time to put all of this documentation together! 28 FoundMyFitness Dr. Nancy McClure-Galli Dr. Nancy McClure-Galli 2 years ago So great to have the micro cellular pathways broken down this way. Also, the analysis of both animal and human studies. Thank you so much for the effortless way you explain potentially mind boggling processes. Helps so much in the decision making process. B Szlado B Szlado 2 years ago Great summary of the topic! I was desperately trying to find actual human published data about NAD+ decreasing with age, but other then the two studies you mentioned, couldn't find much. In those two studies though, sertuin activity actually didn't decrease; there was significant difference between men and women, and the NAD+ decrease was extremely small (vs. the 50% David Sinclair commonly mentions), and in fact looking at the graph, it was quite variable, with some 30 year olds having the same level as 60+.. .so I really wonder if the marked "decrease" in NAD+ everybody goes on and on about is actually a comparison of an active 20 year old vs. a sedentary, unhealthy 50-60 year old; ie. isn't the life style more important than the horrendously expensive NMN and NR supplements? 1 Dustin Phillips Dustin Phillips 2 years ago Thank you for the video. I have been taking Tru Nigen (NR) for about two months at 350 mgs. What I have noticed is a slight increase in energy, and focus. I feel like I have also lost some body fat. However, I stay in Ketosis and use intermittent fasting 4 days a week. However, I plan to stop taking it once my bottle runs out because of the information presented in this video. I don't see the benefits outweighing the potential downsides. Thanks again. 11 profitfever profitfever 2 years ago So glad you covered this. Been listening to lifespan on audio book and he's one of the leading scientists on this research. 8 Gregory Colvin-Garcia Gregory Colvin-Garcia 1 year ago Rhonda, I've heard Dr. Sinclair say he takes 1gram of NMN daily but in reading his book and listening to multiple interviews I'm not sure on the best time metabolically to dose and if there is a "minimum effective" single dose. Currently, I take 250 mg, 3 to 4 times per day sublingually but it occurred to me that each one of these single doses may be below the threshold of effectiveness... 2 Ramon Mensink Ramon Mensink 1 year ago Great video Rhonda! I was wondering if it makes sense to take a NR/NMN supplement while also ingesting carbs/protein/fat. As you also explain in the video, the NAD/NADH ratio in the cell increases when fasting/CR/exercising. Then such a NAD boosting supplement would need to be taken in a fasted state wouldn't it? Or is the pathway of either NR/NMN supplement somehow separated from the metabolic pathway when a cell is in a fasted state? 2 quigonreturns again quigonreturns again 3 months ago Hello! Would love to know your thoughts on methyl group depletion as it relates to Niacinamide supplementation. I have been taking it at 500mg/day, with no ill effects. However, I am cautious about the long term affects of supplementation. Thanks! And love your content! B D B D 9 months ago (edited) Excellent!! Conclusion: Fasting, less calories, regular exercise increases NAD level👍 We all need to wait for using supplement at this point till more data available! 1 David David 2 years ago Great video Rhonda, thank you for all you're doing and the quality information with such strong scientific detail. 2 SpockBoy SpockBoy 2 years ago (edited) Thank you so much for bringing us this information Doctor. Using your great intelligence for altruistic purposes is both rare and wonderful. 3 Steve Wright Steve Wright 1 year ago Many thanks for this detailed walk through! I think correctly identified this is all at an early stage of discovery - perhaps usefully highlighting the key importance of NAD in the cell energy economy, but (to my mind) now pointing to the need to reduce NAD depletion. A whole food plant based (WFPB) diet being inherently low inflammation - perhaps best indicated by White Blood Cell count: https://nutritionfacts.org/video/what-is-the-ideal-white-blood-cell-count/ Also points to a need to remove senescent cells regularly - probably by a number of 5 day water fasts over the year. Lastly - not a bad shout to pay attention to Vit B3 status - if this is insufficient NAD production is likely to be throttled... Thanks Rhonda for this review - appreciated! Morrocco Method Int'l Morrocco Method Int'l 2 years ago So helpful + informative for learning about aging. Thank you for this video! 2 Joseph Khadige Joseph Khadige 1 year ago Great presentation Doc. Thank you. Please excuse my ignorance in this matter but to make sure I am understanding it accurately, if a cancer patient is regularly fasting and exercising (which leads to increase of NAD levels) would that increase the spread and developing of the cancer cells? KenG KenG 6 months ago Excellent analysis and much appreciated! I love your presentation speed and style! 1 Roger Bowman's Fitness & Wellness Coaching Roger Bowman's Fitness & Wellness Coaching 2 months ago Stellar presentation as always, thank you Dr. Patrick! gururaj bsavakar gururaj bsavakar 2 years ago Congratulations! Firstly for the , pleasant, patient presentation, with amazing revelations of test results of NAD, decline with age, using boosters of NAD, & Alternate pathways which work usually but with exceptions!!! Extremely A Great MASTERLY STUDY/ & presentation of all pros- cons of all eventualities . With a final recap!! Thanks for this useful educative share! Many regards! 5 FoundMyFitness Ivan Valdez, PhD Ivan Valdez, PhD 10 months ago Fantastic job, Dr. Patrick. Do you think that sublingual NR/NMN would be effective at increasing NAD+ levels in different tissues And not just blood, similar to Intravenous administration, by bypassing the liver? Cris Clourt Cris Clourt 2 years ago Thanks Rhonda for your amazing research! Do you know what type of trans-resveratrol is best? Does it have to be organic etc...? 2 Vedran Simic Vedran Simic 2 years ago Very interesting. From your video's from Satchin Panda I learned the benefits of time restricted eating regaring insulin sensitivity, sleep, cardiovascular aspect etcetera. Do you have any information whether NAD+ increases also with time restricted feeding and which window of eating you should use? Or is there only information about fasting and increasing NAD+ and if that is the case how long you should fast for increasing NAD+. 1 a2audrey a2audrey 2 years ago I’ve been taking 750mg of NMN + 500mg resveratrol for 6 months. I’m 61 and in good, but far from great shape. My muscle stamina and overall energy are way higher than when I began. I also have noticeable reduction in inflammation in my leg that was damaged in an accident and where it had been chronic for many years. The reduction in inflammation alone keeps me on it, but feeling a lot better is great too. 42 Karla Jean Karla Jean 2 years ago 5 months later and I'm still coming back to relisten to this video. Very informative and so well put together. 2 Noveleffect Noveleffect 2 years ago I really appreciate the chemical reaction explained to me along with the reaction diagrams. So rare to find anything this thorough 4 Harvey Holloway Harvey Holloway 2 years ago Great video. I am 70 and a health fanatic, and still in perfect health. I have a massive coordinated program that did not include this. Now I will be going out today and buying Niacin. I am going to start immediately. Have a wonderful day. ☺😎🐰 4 N C N C 2 years ago I've been doing lots of reading and this is by far the most in depth breakdown I've seen on NR/NMN yet. While I am really impressed with anecdotal evidence of NAD supplements, I am erring on the side of caution. Personally, I'm going to hold off on purchasing supplements until more clinical trials come out so we know proper dosages and whether or not this even carries over from mice to humans. Anyone else feel the same way? If it turns out this is safe, easily replicates in humans etc then I will consider supplementing. 2 Andrew Moore Andrew Moore 1 year ago Superb. So much information explained so efficiently in 30mins. I feel very well informed now, thank you! 1 Ja Wi Ja Wi 2 years ago Good work! You certainly did the research and can explain it with great accuracy. Thank you. Tom Provan Tom Provan 2 years ago This is definitely the best most informative and comprehensive piece of information so far delivered on this topic as far as I am concerned thank you for this video Rob Lovegreen Rob Lovegreen 2 years ago Because of you, I started loving myself with broccoli sprouts. ❤️ I grow them too. Sulforaphane for the win! Thank you 🥦 60 Kuo-Ying Wang Kuo-Ying Wang 6 months ago Excellent and brilliant work. Thank you very much indeed. The literature reviewers are amazingly detailed and strikes the key points of the findings from the researches. Aldous Orwell Aldous Orwell 2 years ago Beautiful! Very comprehensive! Question: does DNA repair have a circadian rhythm? If so, would it be better to take NR in the evenings? Thank you! :-) Christina Lawhorn Christina Lawhorn 2 years ago ** Due to a serious case of mold poisoning I have been on NAD+ IV's for 6 months... they literally saved my life.. I have never had oral NMN or NR. However I would highly recommend anyone with a health issue try NAD+ IV's. There are numerous accounts of people turning their life around due to NAD IV's not precursors. Best wishes to each of you! 1 pravoslavnik pravoslavnik 2 years ago Just found your channel/videos. Your presentations are "spot-on," as the modern expression has it. Loaded with information. Love your vids. I shall be watching them all. PLEASE keep up the good work ! 2 FoundMyFitness Optimize with Science Optimize with Science 2 years ago It is a fascinating topic and I love how scientific Dr. Patrick approaches it! 41 FoundMyFitness alfred Vincent alfred Vincent 1 year ago Great concise presentation as always. Thank you. 2 June Allison June Allison 1 year ago Dr. Rhonda this is the best explanation I've heard on this topic. So thorough and well thought out. Thank you❤ 2 uncle Joe uncle Joe 2 years ago Exciting developments. Great to know scientists are working so hard on our behalf in this crazy world. In the meantime I'll continue my exercise, sauna, and clean diet. Thanks! 1 Cuenta de Youtube Cuenta de Youtube 2 years ago Best unbiased recap of NAD+, NR and NMN. Thank you! Suscribed! 3 C H C H 2 years ago (edited) Regularly growing broccoli sprouts for a couple months now, I put them in my daily smoothies for myself and my family thanks to Dr. Rhonda Patrick. Thank you for all this free info, truly is life changing 36 FoundMyFitness Ken Otwell Ken Otwell 2 years ago Great data - but leaves me with one big question - how much does exercise increase NAD+ and how does that compare with supplementation? Also - is there any synergy between exercise and supplementation? 64 Larry Tate Larry Tate 2 years ago Dr. Patrick thank you for sharing your knowledge. Could you please consider doing a video lecture on CBD and it’s benefits and possible negatives? Thank you Jeff G Jeff G 2 years ago Great video. Now I'm wondering how long it will be until we have solid data on positive effects as well as dosage sizes and methods to experience those effects. Years? How many? Thomas 3108 Thomas 3108 2 years ago Hello, I have one problem taking NMN. Hope you can help with your knowledge 😃🙏 I take 0,5 - 1 gramm Resveratrol in Oliveoil, 0,5 gramm of NMN and 1 gramm of TMG. I started taking TMG as I noticed, that after about 3 days I feel a certain pressure on my heart or let's say on the left side of the breast and I feel like having higher blood pressure. Then I stop the life extension treatment and everything is fine again. When I take only Resveratrol or only TMG this phenomenon doesn't appear. I thought with taking TMG this would stop, but that's not the case. After starting again the same reaction appears. I bought NMN even from Prohealth. The same thing. The dose is really not that high, so I am wondering as the studies don't have such results. I am 45, 1,75 m and about 83 kg. So what's your opinion on that? Thanks in advance, Thomas 1 Bakhtiyar Neyman Bakhtiyar Neyman 2 years ago Instantly one of my favorites videos on Youtube. Thank you so much, Rhonda! 2 Shaji George Shaji George 1 year ago Hi Dr Patrick: Very interesting presentation. In light of the data that you showed that there is a real possibility that NMN and NR are converted into NAM and recycled in the salvage pathway to make NAD, why not consume Nicotinic acid? The recent paper in Cell metabolism showed that NA supplementation in humans with mitochondrial myopathy in a small clinical study showed 2.3 fold increase in muscle NAD in the patients (not in healthy controls) and an 8 fold increase in blood NAD in these patients (5 fold in controls) at 1 g/day over 10 month (escalating dose from 250 mg to 1 g to reduce flushing even though they used a slow-release version of NA). This is much more of an NAD boost than NR or NMN which probably supports the theory (from the metabolic flux study you mentioned) that NMN and NR are converted into NAM and cycled through the salvage pathway thereby negating the advantage of NR and NMN. However, the authors studied only muscle and blood, so it is not clear if NAD levels in other tissues also increased. Other studies have shown that IV administration of NAD can increase NAD levels in brain. So if blood NMN can be raised 5 or 8 fold, then it can cross into the brain (If I remember right, there is some data to show NAD crossing BB barrier although I am if more studies will show it through the NAM route). NA is very cheap and has good safety profile (having been used in high doses as an anti-cholesterol agent in the past). Slow release NA can ameliorate some of the flushing even though some suggest based that the slow release form may cause liver toxicity (very limited data). Would like to hear your thoughts on using NA instead of NR or NMN. Equs Narnd Equs Narnd 1 year ago I'd like to see you do a video on the role of Niacin (Nicotinic acid) on supplying the molecules for the manufacture of NAD+ 11 carpe diem jonah carpe diem jonah 2 years ago (edited) So what are the best relative food sources of NMN? And the best relative food sources of Nicotinamide Riboside? Are some of these foods significantly higher in their capacity to boost NAD levels? Hoping to get it aboard the food supply so there is the safety of letting the body metabolize as needed. SmartCookiesDontCrumble SmartCookiesDontCrumble 1 year ago Thank you so much for giving this teaching on this topic. Valuable information!🥰 2 Rick Kowalchuk Rick Kowalchuk 2 years ago It seems to be a key component involved in aging and possibly reversing the process! Dan O'Hanlon Dan O'Hanlon 1 year ago Very helpful — comprehensive — much appreciated! 2 Waskel E. Wabbit Waskel E. Wabbit 1 year ago (edited) I have been taking 300 mg a day of NAD+ for almost a month. Took about three weeks before I started noticing a difference. It is very subtle but that might be a good thing. There's a fine line between feeling like doing something or not. I have had chronic fatigue for all of my adult life. I am 68 now. Been looking for the magic pill for that long. Getting ready to order my second bottle and I would recommend to anyone with low energy levels or just to possibly live longer. No one I've talked to has heard of this stuff. Would like to get some friends to try it to see if it helps them too. 1 jackwelshh100 jackwelshh100 2 years ago (edited) Very interesting episode. Fantastic work! One question comes to mind: We know that resveratrol is a SIRT-1 activator but are there identified compounds that increase PARP-1 activation (for us with non-supercentenarian genes)? I supplement with NR and resvetral. If there's a PARP-1 specific activator compound, it might be an interesting addition to the mix. 4 David Alzate David Alzate 9 months ago I guess in the section on depletion, it's important to include the studies of CD38, CD157, and PARP. These molecules are impacting the depletion of NAD+. Casey Connor Casey Connor 2 years ago Fantastic as usual! Thanks for the great information! Hey, if you get a chance to circle back on the subject of eating fresh ground broccoli seeds at some point that would be great. Many of us like the taste of them! Or don't notice it when added to food! Erucic acid might be a consideration? Thanks! 2 NADIOL™ NADIOL™ 9 months ago Amazing content as always Rhonda. Dr. Steve Hruby, D.C. Dr. Steve Hruby, D.C. 2 years ago Thank you Dr Patrick this is above and beyond anything that is out there. 1 FoundMyFitness Trey IM2 Trey IM2 2 years ago I had literally finished my bottle of NAD3 the day before this vid dropped. Took my last TMG (DEFINITELY take this with it for methylation. I also take an activated B complex for additional methylation regularly) this morning (skipped yesterday, and I think I took an extra NAD3 by accident so it wasn't 1:1). I had been on this for 4 months straight after taking a month or so off with a 2 or 3 month straight intake prior. I don't know if it improved anything because I take a ton of supplements and herbs to improve my overall health. I plan to take a month or 2 9ff before getting back on NAD3 Wolfram Luchner Wolfram Luchner 2 years ago Exemplary summary. I love how dense with information your videos are. Quite a rarity on youtube! Keep up the good work and thank you for your high quality content! 7 FoundMyFitness Josh Woodle Josh Woodle 2 years ago (edited) Dr. Rhonda, since Dr. Jed's video, I've been eating just the broccoli seeds. Is there any way you could do a video on consuming broccoli seeds vs. sprouts? I burr grind them and sprinkle over food. Very interested in this! AJ Hege AJ Hege 2 years ago Appreciate the info! What are your findings about NADH (NAD bonded with a hydrogen ion)? I hear it has a better delivery system from a doctor on the Ben Greenfield podcast. Peter Davila Peter Davila 2 months ago (edited) I'm 66 years old. I started taking 1g a day of Apigenin a few months ago. Apigenin is one of the ways to raise NAD+. It is amazing how much energy I have now. It feels like the energy that I remember having in my 30s. In addition, in conversation with my neighbors, they have commented that I seem to look younger every year, instead of older. I also take Metformin, even though I do not have diabetes. I also do a lot of intermittent, 3 day water fasts. I'm planning to start on 1g of Fisetin a day for 5 straight days every month in the next few weeks. My diet is free of meat. I do eat sardines, salmon and flounder. Lots of nuts (Walnuts, Cashews), seeds (Flax, Hemp, Chia). Dark Chocolate (80% cocoa). I do drink lots of coffee. I don't drink cow milk but almond milk instead. I don't drink alcohol. Live Long Enough to Live Foreever. Isabella Holden Isabella Holden 2 years ago Amazing video. Thank you for the brilliantly explained content.🇿🇦😎🙏 5 FoundMyFitness Ron RG Ron RG 2 years ago Dr. Rhonda amazingly insightful analysis of the data! Love the topics and videos you make . Thank you so much 1 firehorse_44 alpha-omega firehorse_44 alpha-omega 2 years ago Excellent lecture. Thank you for this presentation Dr. Cheers 10 Entropy Wins Entropy Wins 2 years ago I'd be interested in a video on pterostilbene and thoughts on supplementing that. Kunverji Hirani Kunverji Hirani 1 year ago Hi Rhonda :-) So practically, what do you recommend? Take NMN first thing in the morning? - then how long should you wait before having breakfast? Or can you have breakfast straight away after taking NMN? Many thanks :-) Vijai shankar Srivastava Vijai shankar Srivastava 3 months ago Highli informative video based on different experiments on NMN AND NR. It’s doses n application well covered. Dave Soko Dave Soko 11 months ago Can you boost your NAD levels by taking Niacin or do you have to use the other forms such as nicotinamide riboside or are they the same thing? 1 rzomg rzomg 2 years ago Amazing skills to flood my brain with huge amounts of information. I know how its gonna feel when AI's are smarter than us all its the same feeling I get when I listen to Dr.Rhonda 2 mooky wilson mooky wilson 2 years ago DOC!!!! your the best! I wish there were more docs like you. 4 Launch Medical Media Launch Medical Media 1 year ago This is a wonderful video. We will probably be sending our patients this video when they ask about NAD+ from now on!