#NAD NR & NMN for Anti-Aging

#NAD NR & NMN for Anti-Aging | Took for 9 Months | This is My Experience. 115,049 viewsAug 4, 2020 Life & DIY 20.2K subscribers I took the most popular anti-aging supplements - NR & NMN (to increase NAD+) - for 9 Months and this is my honest experience. MORE⤵ #NAD+ UPDATE! After 3 years of experimenting with longevity supplements, I made my update video here: https://youtu.be/q8WdbqDx7LQ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ PRODUCTS MENTIONED⤵ Thorne Labs NR (Nicotinamide Riboside with Resveratrol and TMG) on their official website: https://thor.ne/Xy4Pw (you can often find a coupon for their site) or available on Amazon $48 for 60 capsules https://amzn.to/3miUQQd Update!!! I have been taking a brand of NMN that I really trust and for anyone interested, they do not sell on Amazon. They do sell here on their main website: https://bit.ly/3mkiLio (use this link to get 10% off your order). Recently they came out with liposomal NMN +, NAD+ & NR in one product and it's currently my favorite supplement: https://bit.ly/3OzIb8n . Use the code: 248555 to get 10% off. I've linked directly to the product I prefer taking, which is their pure powder NMN that can be taken sublingually. They offer such a variety of products that offer different methods to take the NMN. The company is also well-established and has been around for over a decade. They have excellent customer service as well. ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ DISCLOSURE⤵ 1-1-2021: Just recently I began doing sub-contracting work for Alive By Science (now Renue By Science), as I do internet marketing & work online in numerous capacities. I want to give this disclosure on any videos where I have mentioned their products. If you have any questions about their products, you can always ask me and I will find out for you. The work began long, long after this video was posted. ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ RESOURCES TO CHECKOUT ON NAD+ (NR & NMN)⤵ For more information on NAD (Nicotinamide Adenine Dinucleotide) - and NR (Nicotinamide Riboside) & NAD+, simply explained - please see my post here: https://lifeanddiy.com/nicotinamide-r... David Sinclair, scientist, leading the way with self experimentation and research involved in NR, NMN, NAD and anti-aging and longevity. Here is an article he wrote on his website about NR vs NMN - https://lifespanbook.com/nad-boosters/ Another video by David Sinclair - on Why We Age, And Why We Don't Have To: https://www.youtube.com/watch?v=9nXop... ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ ❈ Disclaimer: The Content has been made available for informational and educational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The creator hereby disclaims any and all liability to any party for any direct, indirect, implied, punitive, special, incidental or other consequential damages arising directly or indirectly from any use of the Content, which is provided as is, and without warranties. This content creator is a participant in the Amazon Services LLC Associates Program & other advertising programs, designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon or other sites. This post may contain affiliate links. That means if you click on a link and make a purchase, the site owner will receive a small commission at no cost to you. Thank you for supporting Life & DIY! Please note: I am an affiliate with some products, not all. I do not accept sponsorships or people paying me to review things. Some of the links provided are affiliate links which means I get a small commission with your purchases through them and it doesn't impact you at all or your price. If you aren't comfortable with using those links, please just search for the items aside from my links - as long as you find the product you need, that is just fine! Thanks! Chapters 756 Comments rongmaw lin Add a comment... Aaliyah Lee Aaliyah Lee 4 months ago I had a very mild symptoms of COVID last year....I tested positive! I thought I'd die from COVID. I have hypertension so I worried a lot. It was so timely that my niece brought me NMN Vitruvin supplement which I was taking two weeks before I tested positive. Later I found out that that supplement saved me from dying. Coz not only it improved my health, it also cured the symptoms for days. 22 Tree Walker Tree Walker 1 year ago I'm 68 and have been taking a gram of NMN daily for almost four months. The results are fantastic. I have more energy than I have ever had, even when I was young. But what I have found is that to be really effective, the NMN has to be supplemented with exercise. It seems to give me a little more energy to exercise, and if I take advantage of that and do exercise, the energy multiplies, and keeps multiplying the more exercise I do, till I start craving exercise all the time and jump on the exercise bike every chance I get. But if I can't exercise, the effects of the NMN are not so noticeable. BTW, haven't noticed any effect on my skin so far. 62 Life & DIY Jeff Gilligan Jeff Gilligan 1 month ago I have taken NR for four years, and upped my dose to 900 mg about two years ago. I am 72 and feel about 45. I haven't been sick from anything, and my skin is now smooth rather than rough as it has been on my elbows and knees. 7 Life & DIY NeutroniummAlchemist NeutroniummAlchemist 1 year ago I also started taking NR about the same time that you did. I had a massive boost in energy that lasted for a few weeks, then faded away. Since then, I've switched back and forth between NR and NMN, but I've not experienced that initial surge again. Recently, I started watching Dr. Brad Stanfield's channel. He did some research on different NMN brands, and found that a lot of them when tested actually had no NMN in them! Life is complicated, and it's hard to figure out what is really having an effect, but I think that I've had a better experience with NR than with NMN, but that could entirely be because my NR is from TRU Niagen (from the guy that initially found NR), and that the NMN brands that I've been taking all pretty much are crap. So that says little about the actual relative effectiveness of NR vs NMN. (Though it say a lot about the supplement business). Part of what makes evaluation so difficult is that when I get more energy, I tend to spend it all exercising. Which makes me more tired the next day. But I feel that when I'm exercising, and coming into it rested, that the NR does still help. I think another part of being human that makes evaluation more difficult is the way that we reset our expectations to the new normal. Sure, I might have more energy now, but I'm exercising harder, and overall feel the same. In any case, right now I'm taking niacin, NR, resveratrol, and TMG. 35 B B B B 2 months ago Can I just say that your NAD levels at your age is still pretty high - it decreases rapidly with age. I started taking NMN, TMG and other anti ageing supplements I can afford. 4 years ago The company I use is a British company called DoNotAge it only produces pure products and explains each supplement and it’s benefits it has a group of scientific researchers who are on the cutting edge of this subject, you don’t sound as if you have looked into these things in an in-depth way. David Sinclair has written a book about NMN and the science of ageing and becoming ill, He says ageing is an illness and and we don’t need to have it. He believes in Health span, rather than lifespan although he thinks that age will be extended. My own experience of starting taking in NMN at 70 has drastically changed my life. I can go up ten flights of stairs never touching the hand rails without noticing it, not so before when I was noticing the tole age was having on my health and abilities. people of forty are huffing and puffing while I race ahead !!. Don’t be so uncertain find out about things, never buy things off Amazon most are fakes & the reviews are even more so. Go and look at Vince’s site my NMN experiment. He stared taking NMN 3 years ago and he roots out the fake sellers there is a recent review on the types of products sold on Amazon & Amazon itself is currently banning fake products. Hope you read this and it helps. 2 Richard Ranney Richard Ranney 9 months ago NR and NMN deplete the body of methyl groups, which leads to elevated levels of homocysteine. That increases heart attack risk. In order to counteract this effect, you need to be taking TMG along with your NR. Also, niacin is another precursor of NAD and it is dirt cheap if you don't mind the flushing side effect. Sustained-release niacin and extended-release niacin don't cause flushing, but sustained-release niacin is associated with liver damage and I take plain old niacin (500mg) to be on the safe side. 43 Jess Cox Jess Cox 5 months ago I had a very similar experience with increase in energy levels when I started taking NMM supplements as you had when you started the NR. It was quite pronounced, a really kind of clean, motivated energy. I’m not sure if I still feel like that, I think my baseline energy has improved a lot so I don’t notice the effect anymore. I have a much more pressured job that I never though I would keep up with before. I exercise most days. It’s definitely not a cure all… I’ve still had colds etc but I feel healthier at 43 than I did in a lot of my twenties to be honest! That’s probably down to a lot of other factors also. 13 Life & DIY Rachel Ann Rachel Ann 1 year ago (edited) I’ve been on the fence about trying this supplement for awhile because of how expensive it is. But you’ve convinced me to give it a try! Also you said the energy levels you first experienced with it have gone down since. So how are your energy levels taking it now?? Is it still better then before you started taking it?? Thankyou in advance 🤗🥰plus your channel is becoming one of my favorites!😁🥰 17 Life & DIY Leo D Leo D 6 months ago Can you update us on the precise longevity supplementation you are currently on, and its dosage? Do you take NMN, TMG and? Amazing channel and great video! 2 Life & DIY Cat Man Cat Man 1 year ago I started on NMN just yesterday from a company called rev genetics in the US. I have a number of health issues, heart disease and angina and go through some very difficult days sometimes. I'd been feeling dreadfual since Monday, my NMN arrived Tuseday and I took a double dose to start with then went to the single dose in the evening, and had a single dose this morning. I continued to feel absolutely dreadful mentally but around 5pm I went out and did some shopping. I didn't notice anything at first but the further I walked the more I realised I was speeding up, and on my way back from shopping I was racing down the road. My legs just seemed to want to work as fast as they could and with ease too, I haven't been able to walk like that in years. I didn't expect results so quickly, it will be interesting to see where this leads. 18 Life & DIY craig6t craig6t 5 months ago Hey, your review of NR is very convincing. I've been taking resveratrol for years. I realized early on that this was a special compound. I like the fact that Thorne has this along with quercetin and TMG, all in one capsule. Ordered some just now!! 2 Brendan O Brendan O 1 month ago I still haven't taken any of this yet. Researching. Very close to my isolated testing. Your testimonial and the comments are excellent. I just may try NR now before trying NMN based on your testimonial. Learning about both as precursors. I will eventually test out NAD straight, too, thru IV. I hear the benefits of NMN with trans-resveratrol. I wonder if I could try NR with trans-resveratrol... Will research. I saw that Versa has a good NMN. Wow, TMG, thanks. This is chock-full of value. Not rambling! Watching this for the second time.. Great content. Erica Erica 1 year ago Started taking 100mg NR supplements 2 weeks ago, 1 pill per day, plus resveratrol. I have been running 5 minutes more than usual and I have not felt tired at all afterwards. My muscles feel stronger. I cannot notice anything with regards to my skin yet, but let's see what happens as time goes on. It may be placebo effect, but it's a hell of an effect! 17 Life & DIY Jennifer McRayde Jennifer McRayde 1 year ago Hello, thank you for sharing your experience. I started taking Alive By Science about 2 years ago. I felt the same, a ton of energy and youthfulness. I also took 500 mg of Resveratrol, which after a couple weeks... caused my blood sugar levels to be super high and didn’t feel right. Later, I had some labs done and have 1 of the 4 methyl groups affected. So, now I take Thorne Research (ResveraCel) once or twice a week and just started with Alive By Science - SC NMN capsules (TMG + zinc) intermittently between the ReveraCel. So far so good. The SC NMN capsules are a time release, which is great. Hope this all helps with my experience and helpful. 16 Life & DIY KE KE 4 months ago Hey! Question, did it make you look any younger or improve your skin (smoothnesssl, elasticity, etc?). Did you also notice any changes in your hair? I've heard that it can reverse greys. Thanks! 3 Cat Man Cat Man 1 year ago Update to previous comment: I take 30mg NMN capsules from revgenetics and I find the product to be phenomenal. I've noticed that those who experience almost immediate energy benefits tend to be over 50, though some under 50's also experience rapid results. So if you're under 50 and don't notice any immediate benefits, just keep taking it. There's been phenomenal changes to my skin which has turned very light (I'm brown skinned) and it's texture has never felt so good. My hair was quite long when I started the NMN and it started to go a yellow colour. My Barber laughed when he saw it and suggested there was someting wrong with my shampoo. He gave me the pony tail as he cut it off! But now my normally very white hair is resuming it's natural colour, slowly but very noticeably. My eyebrows give it away most as they are also normally white but it now looks as if I ave two dirty marks over my eyes but is only the hair resuming colour. You can over do the NMN. I've heard that it starts being effective when you take between 300mg and 2000mg, but it's different for the capsule form. 30mg twice daily is enough for positive changes and there are days when I take up to 400mg but you csn't do that for more than two days as it leaves you absolutely exhausted....but I believe that also benefits the body. So my recommendation for the capsules is one twice daily for the first week or until you feel it's tiring you then give it a break for up to a week or even two. Then go back to the twice daily dose. When you notice physical changes you might want to increase the dose for a couple of days. I also take Quercetin and Resveratrol, and was taking TA65 too. TA65 is the only supplement proven to increase telomere length in humans but I get no energy boosts from it, I think it's more of a 'silent' product. I take Quercetin when the NMN starts to exhaust me as I believe this is the best time to take it. Resveratrol shouldn't be taken regularly and I wouldn't purchase it in a combined form, I think that could be counter productive. High intake of Broccolli or Brussells sprouts can be taken as well as or in place of Quercetin. All in all, I think the product I'm taking is excellent, but have no knowledge of taking NMN in powder form. 23 My NMN Experiment My NMN Experiment 1 year ago Hi Holly, very informative and interesting. Great introduction to NR and NMN; very helpful. Re: energy levels; purely anecdotal, but it seems from the comments on my channel that the be people who noticeably feel a boost in energy etc. are those who were either older or were more sedentary, this may also support the theory that a body really needs it. I would be interested to know more about your reason for not buying from Infinite Age any more. I agree, every time I upped my dosage of NMN I had increased appetite and disturbed sleep too :( 10 Life & DIY Monte Craig Monte Craig 1 year ago The NMN has to be stored in freezer otherwise it has a short life as NMN. 15 Bane Bane 1 year ago Your skin is radiant. Obviously 38 isn’t old, but your skin has the tightness of someone in their early to mid twenties 31 Lucky Hanger 13 Lucky Hanger 13 1 year ago When I started taking NR and NMM with resveratrol I had the most vivid dreams, nothing bad...it was like living two lives and I was excited to go to sleep in the evening. The effect lasted a couple of weeks. The excitement about NMN is that it requires only one reaction to make it into NAD+. David Sinclair seems to think it is slightly more effective then NR but offered no proof. I take a bit of each, NR and NMN, about 500 mg total between them. The other niacin that recharges NAD+ is nicotinic acid, it has it own pathway but requires several chemical reactions for the conversion. I take 500 mg to 750 mg a day...super cheap but it does cause flushing, that is why I take 250 mg at a time, above that and I flush. If you don't go into a deep flush....it feels really cool. :) A full flush with itching sucks. :( 21 Life & DIY akextremerickert akextremerickert 7 months ago I've been taking NR precursor for a few years now. I feel good. Though I have been doing allot of research into Nuchido Time + supplement. Basically the company states that taking NAD+ precursors only work very minimally and don't actually fix the underlying cause of NAD diminishing with age. They say their supplement fixes the NAD factory and boosts levels far higher... thoughts??? 2 David A David A 1 year ago A good video! For resveratrol (fat soluble chem compound), it's better to mix it with fat (extra virgin olive oil is preferred due to oleic acid). It also should be trans and micronized. 19 Life & DIY Brendan O Brendan O 1 month ago Oh, you have also inspired me to get my NAD level tested before starting my first NAD precursor. Not sure that I prefer the NAD score from my VA bloodwork. Prefer private testing. Any suggestions on where/who to get my NAD levels checked? Perhaps you stated in your videos. Will rewatch. Will likely test out NR first, then NMN, then that combo product you mention in your other video. Thanks teacher. Great effort and sharing. Love your health comeback. Congratulations! Life & DIY Anonymous Anonymous 1 year ago I felt an instant effect first time taking NMN today. I'll relate it to take 1.5 magic mushroom caps. Like an enlightening. I take resveratrol for a month. I don't get a feeling from it but hope it does it's job. I take that with yogurt and 2 capsules of the cod fat pills. Hopefully this NMN effect stays and hits every dose like this. I might combine my micro dose of mushrooms with NMN next time 14 Sarah Gardner Sarah Gardner 1 year ago (edited) Taking NAD+ for migraines and am on day 3. Already, migraines are going away! My brand: Tru Niagen 300mg 3 Dr. Casey Peavler - The Functional Medicine Doc Dr. Casey Peavler - The Functional Medicine Doc 11 months ago Thank you so much for providing us your experience with NMN/NR. I would look for a good functional medicine doctor in your area to help you with your cortisol and thyroid function because they are intimately related. That being said, I am happy you had a very positive noticeable effect with the NMN/NR. 4 Life & DIY Holly S Holly S 8 months ago (edited) I'm into anti-aging and have hypothyroidism and adrenal insufficiency, both medically diagnosed. I fight constant fatigue so I empathize. When I took DHEA with high hopes, I couldn't tolerate it because of my thyroid condition and I'm sure I needed it. Now I've discovered nmn, I'm going to try that and resveratrol and hope I can take it. I exercise, eat mostly vegetarian, I don't feel or look my condition or my age. I wonder how it would work if I also take collagen peptide. I can go really hard and if you can too, you doing well. You may want to see an endocrinologist though if you haven't already. Thanks. 3 Life & DIY Cheryl Cheryl 11 months ago Hello! Thank you for this informative post! I’m a little confused, though and was wondering if you take NAD, NMN ( and NR? If so, couldn’t locate the NAD brand you’re taking. Would you mind sharing that, pls? It would be much appreciated. Thanks again! 🌷 Life & DIY Joe Joe 5 months ago I'm with you. No matter whether it's placebo or actual effect from mechanics of the supplement, it doesn't matter! If it's placebo, sign me up with the major energy boost! Sounds great! Life & DIY Emil Auriel Emil Auriel 11 months ago (edited) Really interesting video! You talked about fatigue...do you feel that the NR & NMN has stabilized your energy levels much more now? And do you feel a change now after almost 2 years of taking it compared to when you put out the video? (when you had tried it for 9 months) 2 Life & DIY My Love My Love 1 month ago I am also low energy. I was feeling so bad, I told my Dr. if this was the rest of my life I did not want to live. She did test and I was D deficient. The first day I took D3 I was zinging, my body ate it up. So I totally agree that we may get a reaction as our bodies gobble up a nutrient it has lacked. Frankie Frankie 10 months ago (edited) I've taken for first time 125mg NMN and taking about 50mg now every other day + 50 mg Niacin daily . Before this a month of Nicotinamide 250mg. Searching led me to switch out as maybe issue with nicotinamide. Although felt improvements in memory, skin complexion with NE. This is the First time sustained energy release and feel vital as well as cognitive improvement niacin also seems to help with BP meaning a little less BP meds for me. I am on a busy night shift and it's doing wonders for mental stamina just feel good I'm my body. A caution earlier though I did have a racing pulse 1 hour after but I am bit sensitive to medicine that has calmed down drink plenty water. I will stay at this dose taking every other day and nmn every other day for some months. I feel that's alight for my system and may build to 125mg a day. Just have to know your own body. 6 Brendan O Brendan O 1 month ago My biggest thing is to get a test on my telomeres before & after my NR & NMN testing. Covid-19 really hampered the co's offering telomeres testing. CD28 CD28 1 year ago (edited) I did NMN for 6 months. I didn’t receive any noticeable benefits or side effects. I routinely get my blood work done and I never saw any changes . My blood pressure and oxygen levels stayed the same. I also did not notice any differences with my workout output or cosmetic changes. My cardio levels remained the same. And definitely no hair regrowth! I stopped taking it because of the cost and there’s just not a lot of human trials. First, I’m a healthy 43 years who eats a healthy diet and I don’t smoke or drink. As more research gets published, I may try it again in the future. For those looking at NMN or NR for ‘energy’ I did not get any energy boost. For sustainable energy, I’ve found healthy diet, matcha, vitamin D3, zinc, quercetin, k2 stack worked very well for me. 2 Life & DIY cosmo naut cosmo naut 8 months ago I've been taking NR and resveratrol for more than five years. I don't really feel any different than before starting the NR. I'm continuing to use it (at age 67) based on a leap of faith in the science. 8 Graham Fleming Graham Fleming 10 months ago I have had two little tias/ STROKES been on nmn right hand side a wee bit cold but I get through the day a bit tired.also on extra virgin olive oil and metformin. Yes it does help with life. Go for it ! 3 Charles Linder Charles Linder 4 months ago Thanks for sharing! I love the honesty and open mind. :) I find a great benefit in taking NMN with TMG, but whatever seems to work. Life & DIY Kunverji Hirani Kunverji Hirani 1 year ago Hi Holly :-) So practically, what do you recommend? Take NMN first thing in the morning? - then how long should you wait before having breakfast? Or can you have breakfast straight away after taking NMN? Many thanks :-) 1 Life & DIY 3Day FIlm 3Day FIlm 5 months ago Love Thorne used it after NAD drip AMAZING!! clarity, energy and felt like my body was 40 again I am 66yo will continue my experiment with 2 more drips this year. Yes used TMG and nutritional yeast with the capsules 3 weeks after drip. Life & DIY LoveBeni5 LoveBeni5 1 year ago Girl, I just read in the comments you're 38! You look 24! What's your diet? I'm new to your channel 3 Life & DIY D M D M 5 months ago Ashwagandha has been shown to help even out cortisol levels. Thanks for sharing your experience. I've been curious about this topic for some time. 1 Setia Mulyana Setia Mulyana 6 months ago (edited) After seeing experiments on the prevention of premature aging, I see the conclusion that substance supplements such as MNM, etc. only contribute less than 10%, while premature aging activities by way of fitness and diet and keto fasting show more prevention of premature aging >50% , so a substance taken orally that is believed to prevent premature aging is no better than a combination of fitness - diet - fasting. greater bone density ensures the prevention of further premature aging. 7 s e b s e b 8 months ago I really appreciate the way you presented this and the quantities necessary. That's is something usually forgotten by most. Seems like decent amounts (a few grams a day) are necessary for nmn to kick in. Others also indicate taking it with fatty foods to help absorption (yogourt...). 3 Life & DIY Arthi Jayaraman Arthi Jayaraman 1 year ago Hi, thanks for the video. If you are comfortable sharing, did this supplement have impact on your hormones 2 Clay Mation Clay Mation 8 months ago Low Cortisol is supposed to be a good thing. That's the stress hormone you don't want to have too much of it released in your blood stream as it can also raise blood sugar. 2 MsKaterinaKo MsKaterinaKo 1 year ago Just saw they are selling them in UK too, hurrey! Costly but so is a gym membership which you could do at home instead (if I had energy haha). 2 months away from giving birth, but once I'm finished breastfeeding I will go straight on them! Thank you so much for the recommendation as it's hard to know which are fake, like you said some companies are questionable! Side note, recently read that pregnancy shortens your telomeres by about 10 years, so anything with a boost is welcome! :) x Life & DIY moremytrees moremytrees 5 months ago I too have hypothyroidism and suspect hashimoto.. I appreciate you sharing as I’ve ordered some NAD/NR and b complex and saw it explained TMG should be taken together. I want to do this right and plan to do small amounts like you did at first. I’ve been excited because I am also fatigued and felt something is missing in my line of supplements. Please advise on anything that may help. Thank you! samantha porter samantha porter 6 months ago I am going to be starting NMN as soon as it makes it to me in the mail! Super exciting! Hamid Hamid 3 months ago (edited) I have been using niacin for about year for lipid issues. I will buy soon nmn. Thanks alot for sharing your experience! Life & DIY I. Bks I. Bks 7 months ago This has been no rumbling!!! Every word helped me in my research! Thank you!!! Life & DIY Ramzi HA Ramzi HA 1 year ago thank you for sharing your experience sister what about NADH? I heard people taking NADH and having massive energy boost but NADH is expensive like 60 table for 90$ without shipping anyway really excited for the future you guys finally we goona do something about out healthspan people dreamet about this for centries :) 1 Russell Barndt Russell Barndt 3 months ago I really respect your way of humbleness and caution along with willingness to question seemingly yourself. I greatly appreciate you sharing your experiences and what you know while looking for what other people may know... Life & DIY Jeff Jeff 1 year ago Really appreciated the authenticity in this review. I just ordered some and looking forward to it. 7 Life & DIY Jenna Rose Jenna Rose 1 year ago (edited) I have high levels of inflammation in my body which causes an extreme lack of energy. I’m 36 and have four children, so obviously, no bueno. I started taking alive by science NMN and I feel so much better!! I have a ton of energy!! I had never heard of any of these supplements until I stumbled upon your channel. Thank you so much for sharing. 5 Life & DIY Anita Miko Anita Miko 1 year ago I had no idea you suffer from fatigue and never would’ve guessed because you seem so productive with all of your projects around the house and skin care DIY‘s - not to mention the effort of recording for this channel. Makes me wonder what I’m doing with my life LOL since I seem to have bundles of energy… That I’ve been squandering on YouTube ;) In all seriousness, this is motivating. To hear someone struggle to gain something that others naturally possess should push all of us to have a little more to show for it. I’m sure you are this way too (have a natural gift/strength) regarding certain things that others struggle with. 1 Life & DIY simon hanlon simon hanlon 10 months ago It would be a very good idea to have a full blood test done before taking any supplements. I had mine checked and found my folic acid and b12 levels to be borderline low. After sorting that out I feel 100 times better. It would be dangerous to mask a problem that has potential irreversible effects by taking something else. 5 David de Ridder David de Ridder 3 months ago Appreciate this video. I am 49 and just started taking NAD+ Cell regenerator by Life Extension. Feel good. Miguel CGS Miguel CGS 1 year ago Hi. Could you elaborate in the difference you experienced between NR and NMN? You mentioned that they both did have an effect on you, but could you tell the difference? Thank you. SH SH 1 year ago I took TMG with nmn ...first time I felt like I was having a panic attack . So stimulating ... I also have a autoimmune condition and insomnia. I stopped taking it 6 Amuserr Amuserr 1 month ago (edited) Guys please take NR instead of NMN. In my research I found that NMN needs cold storage, otherwise it breaks into other non beneficial compounds. So therefore most NMN are rendered useless in storage and shipping already FreedomFox1 FreedomFox1 8 months ago I get a similar boost in mood and energy with certain anti-inflammatory products. The effect does diminish after the first month. Ultimately you need to “cycle” the product, for it to continue to work (with the exception of essential nutrients you are deficient in). If you want to look into the nutrient side of things, I had great results from Spectracell nutrient testing (although it’s pricey). If anyone wants to try an inexpensive anti-inflammatory for mood and energy, high-dose melatonin (20 mg at bedtime) is a good option (it enters the blood and crosses the BBB much more effectively than other products). I’ve also had good results from taking zinc lozenges 3-4 times per day and a spoonful of high quality olive oil with breakfast and dinner (these probably worked due to nutrient deficiency). Everyone is different, but that’s what worked for me. 6 Life & DIY Kirstin Strand Kirstin Strand 1 month ago I've been using 5 years, 500mg daily, sometimes 1000 mgs. Chris C Chris C 5 months ago Love this video and your honesty and your are genuine, I would suggest you boost nad+ in your system with plants and you will save tons of money. I have nothing against supplement but nmn is far too expensive + lot of manufactures of it recently were scamming people with fake nmn. Elle Cee Elle Cee 3 months ago Hello! You popped up in my feed tonight most likely because I am a huge DIY fanatic of everything & have been reading up again on NMN & NR. I loved your vid because like you I have hypothyroid, suffer from terrible insomnia as well as have several other health issues on board. I used to be a competative athlete & am a polar opposite now.. Anyhow I have so many questions for you from several standpoints. I also come from a licensed beauty, skin, hair, health backgrounds so I’m greatly interested to see if you noticed anything in the way of skin brightening, smoothness, firmness, hair health like thicker or reversal in greys? Also curious to know how things are for you now as far as energy stuff goes.. I’ve tried so many things over the years but ultimately they seem to plateau so I end up taking little breaks from all of it basically. Anyhow I would so love to hear an up to date sort of recap on how your feeling now, results you have seen up to present with each of these areas. I am so glad to have found you & look forward to watching all your vids! Thanks so much for sharing your info! Take care. Life & DIY einsteindrieu einsteindrieu 6 months ago Been taking NAD plus BLACK BOTTLE--I have a lot of energy David takes this stuff. Fekete-Kiss Sándor HangDala Fekete-Kiss Sándor HangDala 8 months ago I got NMN with Resveratrol, Quercetin, Fisetin, Q10 and other combination. Very positive effects, surprising! It’s pricy, but worrh of the money. 3 Life & DIY Angela Perez Angela Perez 1 year ago Love your channel! Your such a beauty 🤩😁💗 I already bought some stuff that you've recommended👍🏻. I'm definitely gonna have to try these items cause I also suffer from hypothyroidism 😩 and most of the time my energy just isn't there 😒 sucks!🤷🏼‍♀️but gotta deal with it. Thanks for the great info and I'm definitely gonna keep watching your channel and giving you a thumbs up😊💗 👍🏻 1 Life & DIY Lilyinthewater Lilyinthewater 6 months ago You could be a brand ambassador for this compound if it ever needs one. Glowing recommendation literally. Have you considered skincare with nmn in it. I'm a hobby formulator and make my own niacinamide serums with reseveratrol. I wonder if incorporating nmn directly could be beneficial. Life & DIY Ethan Ethan 9 months ago On 250mg of NMN daily right now, doesn't seem to increase energy that much for me but it's definitely more noticeable than baseline, I am 20 though so my NAD+ levels should already be fine. I find it has a great mood boost though 5 Alexander Bailey Alexander Bailey 1 month ago Anecdotal evidence on my part. Changed over from 300MG to 500MG last week. Instantly felt the rush of energy and can breathe better. On the treadmill at the gym was able to change the incline from 3.5 to 4.5 and monitored my heart rate and it did not exceed 116BPS. After 30 mins, felt like I could go another 30 mins at 10.8MPH. Persistent One Persistent One 10 months ago (edited) ResveraCel is a bad experiment for testing NMN. The problem is this supplement contains other nutraceuticals like Quercetin, Resveratrol, and Trimethylglycine (TMG). The Resveratrol could be stimulating fasted metabolism. The TMG on its own would be highly energizing if you have methylation defects since it would provide a new path to bring homocysteine back to methionine in the methylation cycle. My guess is that your symptom of feeling very hungry after taking the Thorne supplement is the Resveratrol. Find a pure Resveratrol and see if that symptoms duplicates without taking Thorne. If you want to test NMN, then buy a few different pure NMN and NR supplements and compare the effects with each of these. 2 Amberlei Private Amberlei Private 4 months ago I have chronic fatigue so I’m definitely going to give it a try!! Life & DIY Robert Fleischer Robert Fleischer 5 months ago I have been taking NR for 35 yrs!😄 2 Kristen Anderson Kristen Anderson 1 year ago You look great. I have a question about the LDN and the NMN... can you talk about the difference in the 2 and what changes you attribute to each? I have done alot of research on LDN and am just starting it.. is the effect of the NMN mostly about more energy? thank you 1 Life & DIY Omer Feldman Yofiël Omer Feldman Yofiël 5 months ago Your skin is your health. 💯 Percent correlation. Life & DIY Big Bear Big Bear 6 months ago If youre in the states you can also get NAD directly intravenously through some services, should be 100 times more potent. 1 Brett Mason Brett Mason 1 year ago Thanks for your video, it’s good to get an earnest review. You look the picture of health in the video so you are obviously doing something right! 3 Life & DIY Lance Hitchings Lance Hitchings 1 year ago Hey Holly, great video. Lots of useful info. Just curious, you mentioned that you take up to 3 caps of NR...how much is in each cap, how much total NR do you take per day. Also, I noticed that you and Vince from My NMN Experiment follow each other, great guy. Another guy that I follow is Dr. Brad Stanfield, he's got a lot of great info on NR, NMN & NAD+. Life & DIY creative solutions creative solutions 11 months ago What is the best way to take NADH? I was researching and a lot of people say you have to take it first thing in the morning on an empty stomach… They say this because some people were reporting feeling ill if they took it with food. I also think I have methylation issues so I take TMG with it… This is also suggested to take on an empty stomach… Any thoughts on this or do you have any experience with us? Strangeloop Strangeloop 10 months ago “I signed up for College a couple hours away” 😂 That’s awesome… 3 Life & DIY jaylife jaylife 2 months ago You might have mold in your home making you feel run down. Mold can make you sensitive to things like supplements. Aaron Catolico Aaron Catolico 2 months ago I always think it's funny when some girl in her 20's or early 30's tries to teach people how to look young/younger. Wait until you're around 38-40, then come back to make tutorials & talk to us. At that point is when you'll fully understand from real experience what it's like to age. Madben 99 Madben 99 10 months ago Just a quick note---- I'm sure you know this, but I'll recap in case anyone doesn't. Tsh(thyroid stimulating hormone) gets higher when your 'furnace' needs to produce more energy. You then create t4 which is converted to t3 which is your furnace energy. Typical treatment for hypothyroid is t4(synthroid, etc) that you body converts to t3 for energy. If the conversion doesn't work as well for you (remember it takes a while to ramp up), then you have a couple options. One is to supplement with t3(cytomel) as well as t4, which will get you going. Or,...... take armour thyroid that has t4 and t3 in it. The second option worked better for me, easier to control. switching from t4(synthroid, etc) to amour thyroid (which has t4 and t3). 1 Life & DIY Alfred Hitchcock Alfred Hitchcock 3 months ago Thanks for your vlog I will try NMN I have been having problems with energy, muscle repair and recovery as a 35 yrs old That’s why I will do everything in my powers to restore my youthful energy and vibrance And not fall or succumb into depression or chronic fatigue syndrome Life & DIY Rosa Sosa Josendi Rosa Sosa Josendi 3 weeks ago Do you take liposomal? What brands do you recommend? FoundMyFitness 427K subscribers In this episode, Rhonda explains what NAD+, why it is so important for aging and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, what animal and human data says and some concluding thoughts. NAD+ is crucial for our survival. Small amounts of it can be obtained in the diet, but the body recycles it to get most of what it needs. Unfortunately, day to day living plus normal aging can cause NAD+ levels to drop. This causes metabolic and mitochondrial dysfunction, as well as many of the other problems and conditions associated with aging like elevated DNA damage. NAD+ levels can go up when we exercise or fast, but NAD+ precursors like nicotinamide riboside and nicotinamide mononucleotide can also increase NAD+ levels in a dose-dependent manner. However, most of the data on NAD+ boosters comes from animal studies. Whether these boosters are effective – and safe – long-term in humans is still a big question. ▶︎ Get the episode's show notes, timeline, and more https://www.foundmyfitness.com/episod... Chapters 00:00:00 - Introduction 00:01:01 - Aging 00:02:47 - Overview 00:07:35 - Depletion 00:09:19 - Supplementation 00:11:26 - Animal studies 00:13:47 - Cancer 00:15:57 - Dosage 00:25:44 - Human data 00:28:25 - Storage 00:29:00 - Recap ▶︎ Detailed overview of NAD+ https://www.foundmyfitness.com/topics... ▶︎ Detailed overview of nicotinamide riboside https://www.foundmyfitness.com/topics... ▶︎ Detailed overview of nicotinamide mononucleotide https://www.foundmyfitness.com/topics... ▶︎ Did you enjoy this podcast? If you want to support me in getting more of this free information out to the public, please consider becoming an FMF premium member! In doing so, you'll also get access to exclusive member benefits, such as a private podcast feed offering early access and occasional bonus episodes, monthly live Q&As with me, a members-only library that includes presentation slides with all of the supporting figures, graphics, references, and quotes. Also included are Rhonda's private notes on topics discussed in the podcast, bi-monthly member-exclusive Science News Digest email, and more. Thank you for your consideration! Learn more here: https://www.foundmyfitness.com/premium ▶︎ Gain valuable insights by running your raw genetic data through the FoundMyFitness report https://www.foundmyfitness.com/geneti... Chapters Featured playlist 32 videos Just Me FoundMyFitness 1,258 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 2 years ago (edited) 00:00:00 - Intro. 00:00:48 - Nicotinamide riboside supplementation in humans has been shown to raise NAD+ levels in white blood cells. 00:02:47 - Overview of NAD+ 00:05:12 - NAD+ plays an important role in mitigating DNA damage. 00:05:30 - Excessive DNA damage can decrease NAD+ levels by 20-30%. 00:05:42 - Lymphoblastoid cells from centenarians show increased PARP-1 activity. 00:05:55 - Between different species of mammals, higher PARP-1 activity is strongly associated with a longer lifespan. 00:06:36 - Lower organism evidence: A second copy of SIR2, a yeast sirtuin, gave rise to a 30% extension of lifespan. 00:06:43 - NAD+ is required for the activation of sirtuins, which epigenetically regulate a variety of stress response-related processes. 00:07:03 - Energy stress, such as from fasting, exercise, or caloric restriction, increase the NAD+:NADH ratio. 00:07:37 - NAD+ becomes depleted in the brain, heart, and skeletal muscle as we age. 00:08:13 - Decline in NAD+ levels have been associated with many broad categories of clinical disease such as neurodegenerative, cardiovascular, infectious, musculoskeletal. 00:08:48 - NAD+ supplementation has been shown to increase lifespan in models of aging in yeast, worms, and rodents. 00:09:48 - In contrast to de novo synthesis, the predominant source of NAD+ in the body is via the salvage pathway, which is subject to feedback inhibition by nicotinamide. 00:11:56 - Animal studies have shown nicotinamide riboside supplementation is able to increase insulin sensitivity, increase endurance and strength, reverse mitochondrial damage, increase mitochondrial biogenesis, and reverse muscular atrophy. 00:12:30 - Nicotinamide riboside has shown positive effects on the brain in animal, such as increased neurogenesis, decreased cognitive deterioration, decreased amyloid-beta production, and increased synaptic plasticity. 00:12:50 - Nicotinamide mononucleotide has been shown in animals to counter an obesogenic diet, improve markers of metabolic health, improve heart function, and improve cognition and memory. 00:13:10 - A 12-month dietary study of nicotinamide mononucleotide suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies in mice. 00:13:47 - NMN has been shown to increase cancer progression in a specialized senescent cell-dependent pancreatic cancer model in mice. 00:15:57 - Plausibility of dosing: comparing animal and human doses. 00:18:05 - Tissue-specific metabolism and bioavailability of NR and NMN. 00:24:32 - Oral administration of NAD produces NR and NMN in the intestine. 00:24:19 - Intravenous administration of NAD, rather than its precursors, shows interesting results: an increase of NAD content and sirtuin expression in the hypothalamic region of the brain. 00:26:15 - Human study #1: 250mg of NR + 50 mg pterostilbene increased blood NAD+ levels by 40%, while a double dose (500 mg NR + 100 mg pterostilbene) increased blood NAD+ levels by 90%. Additionally, there was a decrease in blood pressure, and ALT (a marker for liver health). 00:27:12 - Human study #2: 500mg NR twice daily for six weeks increased NAD+ levels in white blood cells by 60%. 00:29:08 - Concluding thoughts and recap. 254 pablopolski pablopolski 2 years ago Concise, comprehensive, and articulate. I don't even need to speed it up to get through the information. Well done. 373 FoundMyFitness Chuck A Chuck A 2 years ago Congratulations Rhonda you have smashed the record for total mentions of "Nicotinamide and Nicotinamide Mononucleotide" without stuttering, giggling or entering a comatose state. Kudos! 185 Chris Benton Chris Benton 2 years ago Excellent lecture, well put together, a good balance of pros and cons, useful diagrams and a clear summary at the end. Perfect presentation technique. 112 FoundMyFitness Rich Rozmarn Rich Rozmarn 2 years ago Great presentation, thank you so much. I take NAD with R-Lipoic acid, D-Ribose and Resveratrol for a pre workout. I work out 3-4 times a week and feel as good as when i was 40, now 60. 52 a2audrey a2audrey 2 years ago I’ve been taking 750mg of NMN + 500mg resveratrol for 6 months. I’m 61 and in good, but far from great shape. My muscle stamina and overall energy are way higher than when I began. I also have noticeable reduction in inflammation in my leg that was damaged in an accident and where it had been chronic for many years. The reduction in inflammation alone keeps me on it, but feeling a lot better is great too. 42 Rob Lovegreen Rob Lovegreen 2 years ago Because of you, I started loving myself with broccoli sprouts. ❤️ I grow them too. Sulforaphane for the win! Thank you 🥦 60 Dustin Phillips Dustin Phillips 2 years ago Thank you for the video. I have been taking Tru Nigen (NR) for about two months at 350 mgs. What I have noticed is a slight increase in energy, and focus. I feel like I have also lost some body fat. However, I stay in Ketosis and use intermittent fasting 4 days a week. However, I plan to stop taking it once my bottle runs out because of the information presented in this video. I don't see the benefits outweighing the potential downsides. Thanks again. 11 DAVID EVANS DAVID EVANS 2 years ago (edited) Rarely do we find in the study of nutrition, detail like presented in this video, yet at the same time Rhonda is able to get to her final conclusion without leaving everyone in the weeds. Extremely well done. Combined with Dr. Nicholas Pericone and Dr. Jason Fung, we are starting to get a handle on what is necessary to make critical changes in our life for optimal health... 8 Scott Joshua Scott Joshua 2 years ago What a herculean effort and a testament to your ability to grind it out for hours on end. You’re incredible Rhonda. 15 FoundMyFitness No Limit No Limit 2 years ago A very professional very well presented lecture . English is my 4th. language and I did not have any real problem to understand it and learn from it. Doc, I really appreciate your effort to create this video. Thank you. 7 FoundMyFitness Ken Otwell Ken Otwell 2 years ago Great data - but leaves me with one big question - how much does exercise increase NAD+ and how does that compare with supplementation? Also - is there any synergy between exercise and supplementation? 65 Cat Man Cat Man 1 year ago I've been taking a low doseage of NMN for a couple of weeks now. I started with 100mg in the morning and 50mg at night on the first day, then 50mg the next morning. I hadn't been expecting any results for at least a week or so. About 2 hours after taking that second morning dose I went out shopping and was astonished to find my legs wanting to walk faster and faster, as if under their own volition. I've not walked like that in almost 7 years. I've had a number of strokes and suffer numerous symptoms, manly to do with inhibitted activity levels. My mind is foggy most of the time and the NMN has not done anything for that, but I certainly feel the difference in energy levels, it's really amazing. I also found that after a few days I had to stop the NMN for a couple of days as it seemed to be making me feel more groggy, so I now take it 2 days on, 2 days off. The brand I'm using is an American Brand called RevGenetics, and it's called Advanced NMN, in capsule form. I know it's also available in powder form too. It's quite expensive even in capsule form and would cost the earth to take it regularly at the doseages recommended in this video, but I can assure anyone that the effects at the doseage I am on are truly amazing. 5 C H C H 2 years ago (edited) Regularly growing broccoli sprouts for a couple months now, I put them in my daily smoothies for myself and my family thanks to Dr. Rhonda Patrick. Thank you for all this free info, truly is life changing 36 FoundMyFitness Xotaic Xotaic 2 years ago The year is 2063, Dr Rhonda Patric still looks 23 and now posseses levitation has awakened her 3rd eye. 114 Jason Humm Jason Humm 2 years ago I've been taking 1g of NR daily for 2 years. I find that I don't get jet lag or hangovers anymore. My contribution to this fascinating science. 16 native Texan native Texan 2 years ago (edited) Seems Fasting, calorie restriction and exercising is about the only thing that works for the moment. No magic pill. Great information 👍 72 Gregory Colvin-Garcia Gregory Colvin-Garcia 1 year ago Rhonda, I've heard Dr. Sinclair say he takes 1gram of NMN daily but in reading his book and listening to multiple interviews I'm not sure on the best time metabolically to dose and if there is a "minimum effective" single dose. Currently, I take 250 mg, 3 to 4 times per day sublingually but it occurred to me that each one of these single doses may be below the threshold of effectiveness... 2 KenG KenG 6 months ago Excellent analysis and much appreciated! I love your presentation speed and style! 1 Joseph Khadige Joseph Khadige 1 year ago Great presentation Doc. Thank you. Please excuse my ignorance in this matter but to make sure I am understanding it accurately, if a cancer patient is regularly fasting and exercising (which leads to increase of NAD levels) would that increase the spread and developing of the cancer cells? Tony Westbrook Tony Westbrook 2 years ago I learn so much here by your presentation and documentation. Thank you Rhonda for taking, what must be a lot of time to put all of this documentation together! 28 FoundMyFitness David David 2 years ago Great video Rhonda, thank you for all you're doing and the quality information with such strong scientific detail. 2 Harvey Holloway Harvey Holloway 2 years ago Great video. I am 70 and a health fanatic, and still in perfect health. I have a massive coordinated program that did not include this. Now I will be going out today and buying Niacin. I am going to start immediately. Have a wonderful day. ☺😎🐰 4 B D B D 9 months ago (edited) Excellent!! Conclusion: Fasting, less calories, regular exercise increases NAD level👍 We all need to wait for using supplement at this point till more data available! 1 gururaj bsavakar gururaj bsavakar 2 years ago Congratulations! Firstly for the , pleasant, patient presentation, with amazing revelations of test results of NAD, decline with age, using boosters of NAD, & Alternate pathways which work usually but with exceptions!!! Extremely A Great MASTERLY STUDY/ & presentation of all pros- cons of all eventualities . With a final recap!! Thanks for this useful educative share! Many regards! 5 FoundMyFitness profitfever profitfever 2 years ago So glad you covered this. Been listening to lifespan on audio book and he's one of the leading scientists on this research. 8 Morrocco Method Int'l Morrocco Method Int'l 2 years ago So helpful + informative for learning about aging. Thank you for this video! 2 SpockBoy SpockBoy 2 years ago (edited) Thank you so much for bringing us this information Doctor. Using your great intelligence for altruistic purposes is both rare and wonderful. 3 Ja Wi Ja Wi 2 years ago Good work! You certainly did the research and can explain it with great accuracy. Thank you. Dr. Michael Moeller Dr. Michael Moeller 2 years ago I personally get NAD IVs@24:30 and use them with my patients and notice an increase in energy and improved cognition. 31 Equs Narnd Equs Narnd 2 years ago I'd like to see you do a video on the role of Niacin (Nicotinic acid) on supplying the molecules for the manufacture of NAD+ 11 Karla Jean Karla Jean 2 years ago 5 months later and I'm still coming back to relisten to this video. Very informative and so well put together. 2 alfred Vincent alfred Vincent 1 year ago Great concise presentation as always. Thank you. 2 Andrew Moore Andrew Moore 1 year ago Superb. So much information explained so efficiently in 30mins. I feel very well informed now, thank you! 1 Cris Clourt Cris Clourt 2 years ago Thanks Rhonda for your amazing research! Do you know what type of trans-resveratrol is best? Does it have to be organic etc...? 2 Ramon Mensink Ramon Mensink 1 year ago Great video Rhonda! I was wondering if it makes sense to take a NR/NMN supplement while also ingesting carbs/protein/fat. As you also explain in the video, the NAD/NADH ratio in the cell increases when fasting/CR/exercising. Then such a NAD boosting supplement would need to be taken in a fasted state wouldn't it? Or is the pathway of either NR/NMN supplement somehow separated from the metabolic pathway when a cell is in a fasted state? 2 Cuenta de Youtube Cuenta de Youtube 2 years ago Best unbiased recap of NAD+, NR and NMN. Thank you! Suscribed! 3 pravoslavnik pravoslavnik 2 years ago Just found your channel/videos. Your presentations are "spot-on," as the modern expression has it. Loaded with information. Love your vids. I shall be watching them all. PLEASE keep up the good work ! 2 FoundMyFitness Kuo-Ying Wang Kuo-Ying Wang 6 months ago Excellent and brilliant work. Thank you very much indeed. The literature reviewers are amazingly detailed and strikes the key points of the findings from the researches. Matt Sterba Matt Sterba 2 years ago Let me save you 30 minutes: We do not yet know enough about NAD+ to warrant supplementation. Enjoy those 30 extra minutes that you now have. 30 Jeff G Jeff G 2 years ago Great video. Now I'm wondering how long it will be until we have solid data on positive effects as well as dosage sizes and methods to experience those effects. Years? How many? uncle Joe uncle Joe 2 years ago Exciting developments. Great to know scientists are working so hard on our behalf in this crazy world. In the meantime I'll continue my exercise, sauna, and clean diet. Thanks! 1 Isabella Holden Isabella Holden 2 years ago Amazing video. Thank you for the brilliantly explained content.🇿🇦😎🙏 5 FoundMyFitness Bakhtiyar Neyman Bakhtiyar Neyman 2 years ago Instantly one of my favorites videos on Youtube. Thank you so much, Rhonda! 2 Tom Provan Tom Provan 2 years ago This is definitely the best most informative and comprehensive piece of information so far delivered on this topic as far as I am concerned thank you for this video Casey Connor Casey Connor 2 years ago Fantastic as usual! Thanks for the great information! Hey, if you get a chance to circle back on the subject of eating fresh ground broccoli seeds at some point that would be great. Many of us like the taste of them! Or don't notice it when added to food! Erucic acid might be a consideration? Thanks! 2 Dr. Nancy McClure-Galli Dr. Nancy McClure-Galli 2 years ago So great to have the micro cellular pathways broken down this way. Also, the analysis of both animal and human studies. Thank you so much for the effortless way you explain potentially mind boggling processes. Helps so much in the decision making process. Dr. Steve Hruby, D.C. Dr. Steve Hruby, D.C. 2 years ago Thank you Dr Patrick this is above and beyond anything that is out there. 1 FoundMyFitness Anh Nguyen Anh Nguyen 2 years ago Thank you for such an educational clip . Please keep it up 3 Peter Davila Peter Davila 2 months ago (edited) I'm 66 years old. I started taking 1g a day of Apigenin a few months ago. Apigenin is one of the ways to raise NAD+. It is amazing how much energy I have now. It feels like the energy that I remember having in my 30s. In addition, in conversation with my neighbors, they have commented that I seem to look younger every year, instead of older. I also take Metformin, even though I do not have diabetes. I also do a lot of intermittent, 3 day water fasts. I'm planning to start on 1g of Fisetin a day for 5 straight days every month in the next few weeks. My diet is free of meat. I do eat sardines, salmon and flounder. Lots of nuts (Walnuts, Cashews), seeds (Flax, Hemp, Chia). Dark Chocolate (80% cocoa). I do drink lots of coffee. I don't drink cow milk but almond milk instead. I don't drink alcohol. Live Long Enough to Live Foreever. 1 Dan O'Hanlon Dan O'Hanlon 1 year ago Very helpful — comprehensive — much appreciated! 2 quigonreturns again quigonreturns again 4 months ago Hello! Would love to know your thoughts on methyl group depletion as it relates to Niacinamide supplementation. I have been taking it at 500mg/day, with no ill effects. However, I am cautious about the long term affects of supplementation. Thanks! And love your content! Erin Greer Erin Greer 2 years ago Thanks for so much important information. I hope more studies in humans are coming. Jack Brown Jack Brown 2 years ago Great video. Would you be as kind as to consider making a review of studies on NADH supplementation ? 1 Wolfram Luchner Wolfram Luchner 2 years ago Exemplary summary. I love how dense with information your videos are. Quite a rarity on youtube! Keep up the good work and thank you for your high quality content! 7 FoundMyFitness Ro Bo Ro Bo 2 years ago Wow talk about informative video thank you , I’ve been taking a product which contains Nicotinamide 250 mg twice a day with botanical mix alpha lipoic acid vitamin c and zinc which apparently works on the salvage pathway you have described. The company claim that Despite all the hype surrounding the use of precursors such as NR and NMN to boost NAD+, our cells actually make nearly all of the NAD+ they need using NAM ,as you described in your presentation. They go on to say That “as we get older, levels of the NAMPT enzyme are known to decline and the salvage pathway becomes inefficient at converting NAM into NAD+. In fact this is known to be one of the main reasons that cellular NAD+ declines as we get older. This means that if we want to make sure that NAM doesn’t build up in the cell, then we must make sure that NAMPT and the salvage pathway are working optimally, like they were in young cells. Rather than simply trying to fix falling NAD+ levels by putting more raw material into the cell (using precursors) the product is designed to fix the underlying reasons why NAD+ is actually declining, namely the failing salvage pathway. I am however concerned of the effect of Nicotinamide on sirt2, they claim however that Nicotinamide does not effect sirtuins if it doesn’t hang around for a long time when the salvage pathway is working properly . I just wondered what your thoughts are on this. Again many thanks for your very detailed video 2 Steve Wright Steve Wright 1 year ago Many thanks for this detailed walk through! I think correctly identified this is all at an early stage of discovery - perhaps usefully highlighting the key importance of NAD in the cell energy economy, but (to my mind) now pointing to the need to reduce NAD depletion. A whole food plant based (WFPB) diet being inherently low inflammation - perhaps best indicated by White Blood Cell count: https://nutritionfacts.org/video/what-is-the-ideal-white-blood-cell-count/ Also points to a need to remove senescent cells regularly - probably by a number of 5 day water fasts over the year. Lastly - not a bad shout to pay attention to Vit B3 status - if this is insufficient NAD production is likely to be throttled... Thanks Rhonda for this review - appreciated! Larry Tate Larry Tate 2 years ago Dr. Patrick thank you for sharing your knowledge. Could you please consider doing a video lecture on CBD and it’s benefits and possible negatives? Thank you Roger Bowman's Fitness & Wellness Coaching Roger Bowman's Fitness & Wellness Coaching 3 months ago Stellar presentation as always, thank you Dr. Patrick! Christina Lawhorn Christina Lawhorn 2 years ago ** Due to a serious case of mold poisoning I have been on NAD+ IV's for 6 months... they literally saved my life.. I have never had oral NMN or NR. However I would highly recommend anyone with a health issue try NAD+ IV's. There are numerous accounts of people turning their life around due to NAD IV's not precursors. Best wishes to each of you! 1 Optimize with Science Optimize with Science 2 years ago It is a fascinating topic and I love how scientific Dr. Patrick approaches it! 41 FoundMyFitness Vedran Simic Vedran Simic 2 years ago Very interesting. From your video's from Satchin Panda I learned the benefits of time restricted eating regaring insulin sensitivity, sleep, cardiovascular aspect etcetera. Do you have any information whether NAD+ increases also with time restricted feeding and which window of eating you should use? Or is there only information about fasting and increasing NAD+ and if that is the case how long you should fast for increasing NAD+. 1 rzomg rzomg 2 years ago Amazing skills to flood my brain with huge amounts of information. I know how its gonna feel when AI's are smarter than us all its the same feeling I get when I listen to Dr.Rhonda 2 kineticx kineticx 1 year ago Awesome, best NAD video so far, you saved days of research in such information dense video, awesome work Aldous Orwell Aldous Orwell 2 years ago Beautiful! Very comprehensive! Question: does DNA repair have a circadian rhythm? If so, would it be better to take NR in the evenings? Thank you! :-) Bart Bart 2 years ago Thanks for the good video! I was wondering where is the source for the statement that NAD is lower in older human muscle compared to young. Does this data exist? 2 Creighton Freeman Creighton Freeman 2 years ago It sounds like senolytics should be taken with NAD+ boosters to mitigate the potential for renegade senescent pancreatic cells. David Sinclair also mentioned that Niacinamide inhibits Sirtuins, but since it is also converted to NAD+ that didn't make sense to me. The saturated conversion pathway may explain that, but then the question becomes at what dosage of Niacinamide does the pathway reach saturation? At least one publication by Hwang and Song, ("Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells." Cell Mol Life Sci. 2017 Sep;74(18) ) suggests that since Niacinamide is rapidly converted to NAD+ in cells it only temporarily inhibits Sirtuins followed by an increase in NAD+ and increase in Sirtuin activity. If this interpretation is correct it opens the possibility of using a much less expensive compound as an NAD+ booster and Sirtuin activator. Do you have any additional information or thoughts on the potential of Niacinamide as an NAD+ booster? 5 Ryan Mckenna Ryan Mckenna 1 year ago A Great presentation and very informative. This research sounds promising. 1 Nathan Nathan 2 years ago Great video, thank you for quality information! 2 Stephen Hurst Stephen Hurst 1 year ago Thank you so much for the thorough long-form video, all of this information is very important. 1 Aston Fallen Aston Fallen 2 years ago Thanx Rhonda, for an excellent presentation ! I've heard about this mainly from David Sinclair - I am following closely, and I look forward to more input from you ! TheGrasspond TheGrasspond 2 years ago You are absolutely awesome!! This was very helpful. Thank you 1 MotoDoc ADV MotoDoc ADV 2 years ago Damn. I need an IV of this channel straight into my brain. Oh, and that other stuff you were talking about, as well. 122 FoundMyFitness Entropy Wins Entropy Wins 2 years ago I'd be interested in a video on pterostilbene and thoughts on supplementing that. Ron RG Ron RG 2 years ago Dr. Rhonda amazingly insightful analysis of the data! Love the topics and videos you make . Thank you so much 1 B Szlado B Szlado 2 years ago Great summary of the topic! I was desperately trying to find actual human published data about NAD+ decreasing with age, but other then the two studies you mentioned, couldn't find much. In those two studies though, sertuin activity actually didn't decrease; there was significant difference between men and women, and the NAD+ decrease was extremely small (vs. the 50% David Sinclair commonly mentions), and in fact looking at the graph, it was quite variable, with some 30 year olds having the same level as 60+.. .so I really wonder if the marked "decrease" in NAD+ everybody goes on and on about is actually a comparison of an active 20 year old vs. a sedentary, unhealthy 50-60 year old; ie. isn't the life style more important than the horrendously expensive NMN and NR supplements? 1 Rick Kowalchuk Rick Kowalchuk 2 years ago It seems to be a key component involved in aging and possibly reversing the process! Rick McGhee Rick McGhee 11 months ago Holy crap, this was amazing. This 30 minute video took me 2 hours to get through. Had to pause and read and then pause and research. Thank you!!! 1 Noveleffect Noveleffect 2 years ago I really appreciate the chemical reaction explained to me along with the reaction diagrams. So rare to find anything this thorough 4 Chad Aitken Chad Aitken 2 years ago Thanks for the effort on the video. Can anyone get the Parp-1 activity level test? Do we know what happens in the Salvage pathway recycle that lowers levels as we age? I seen reports that % gains is not good enough in older people since it’s so low? What is NAD+? 99,819 viewsApr 29, 2021 2.4K DISLIKE SHARE DOWNLOAD THANKS CLIP SAVE Dr Matt & Dr Mike 354K subscribers In this video, Dr Mike explains what NAD+ and NADH is!?! Featured playlist 32 videos Biochemistry Dr Matt & Dr Mike 188 Comments rongmaw lin Add a comment... Vivin Vincent Vivin Vincent 1 year ago doc showing his gains , vascularity and dropping knowledge bombs. cheers. 104 conner rad conner rad 1 year ago I normally struggle with understanding chemistry, but you explained it in a way that was straightforward, but still easy to comprehend. I very much enjoyed this video. 21 Kara Langley Kara Langley 4 months ago Wow, finally understand why I’m getting energy from my NAD+ boosters. Living the fasting and NAD boosted life!! Love this video, thanks!!! 4 Relissa D'Souza Relissa D'Souza 1 year ago Another amazing video!! Really love watching your lectures simply because of how you break down the concept and make it much more easier to grasp. Thank you sir! :) Stella Stella 3 months ago Hi Doc, I've seen some research on NAD+/NADH and the potential anti-aging benefits... could you comment on that? and also would it make a difference in whether you take NAD+ or NADH supplements? I also read in some journals that the NAD+/NADH ratio changes as we age but I'm not sure if there is enough research to support that... your input would very much be appreciated!!! 2 eloosivegem eloosivegem 9 months ago THANK YOU! I was struggling with the concept of NAD+ vs NADH but understood everything else in my materials. Thank you for breaking it down, you made it make sense!!! 4 Kate Kate 1 year ago Phenomenal explanation! Wish I had this from an enthused professor about 12 years ago during my Microbio undergrad! 8 Darkjestermayhem Darkjestermayhem 1 year ago New to the channel, thank you for making each and every one of your videos, they are well done, very informative and break down the subject matter in a very understandable, efficient and productive manner, my classmates and I are very grateful for your hard work and continued inspiration, the effort you put into your craft is very much appreciated and has helped to not only meet but to exceed our expectations, please keep up the great work Dr.😁 2 Адл Адл Адл Адл 3 months ago Mike, you are an absolutely amazing teacher! Please keep doing your job and we will support you! 1 Dr Matt & Dr Mike Srijanee Dhar Srijanee Dhar 11 months ago I have been struggling to understand the process , thank you so much. This video is outstanding. •NancyyBabyy• •NancyyBabyy• 1 month ago 1: what is the correlation between high uric acid levels and nad+ iv therapy and whether or not it’s safe to do? 2: is it effective to use precursor supplements via salvage pathways along with nad+ or nadh direct supplementation by iv or injection? Dr Ashok Kumar MBBS Dr Ashok Kumar MBBS 4 months ago Excellent narration of complex topic in very easy manner ..respect🥰 2 Brendan O Brendan O 3 months ago Outstanding lesson. Thank you. THELIFEOFPRICE THELIFEOFPRICE 10 months ago Been doing nad+ iv infusions a couple of times a month. Loved the breakdown you gave =D 21 Mudassar Hussain Mudassar Hussain 7 months ago You nailed it, bro. Thanks a lot, I understood it the first time in life. 1 Acoustic Motorbike Acoustic Motorbike 8 months ago That was so well explained and I still didn't grasp it completely. I understand the outline and will have to watch again. But great simple explanation. 1 BIOS:VR BIOS:VR 6 months ago Thank you for this video. It was incredibly helpful. yoe91 Rugby yoe91 Rugby 7 months ago Thanks for this. My virtual classes are in french, but this was easier to understand in english lol. Straight to the point. 2 Cab Abc Cab Abc 10 months ago Wow, you've cleared all my doubts Thank you 😊 4 Tris Tris 1 year ago You explained it so well! Not even a person with PhD could do it like that! Thanks! 12 james2488 james2488 1 year ago I have no idea what any of that means, but it sounds important, so I’m glad it happens I suppose! 27 شيماء صلاح شيماء صلاح شيماء صلاح شيماء صلاح 9 months ago The BEST explanation. Exactly what I wanted 2 Guthrie # 1 Guthrie # 1 6 months ago (edited) I took 260 mg of nicotinamide adenine dinucleotide and it was no placebo. Increased energy, mood, and focus all day long. I’m going to proceed with caution until more research is done on its tumorigenic potential and impact on sirtuens, but damn. I’m not going to name the manufacturer in case someone thinks I have a vested interest, but this stuff works. Obviously consult your doctor before taking any supplements. 3 Rebecca Rebecca 10 days ago I still don't really know the benefits of NAD+ therapy. But it was good chemistry explanation :). 1 Genesis Ansbro Genesis Ansbro 8 months ago Is it a coincidence that this video was recommended to me after watching Tim Pools experience with COVID?? 5 Travis Travis 8 months ago Wish I could find an IV clinic that does this! Hopefully the supplements are not just a waste of money. 2 Zul O Curran Zul O Curran 11 days ago Excellent video. Could you explain UCP enzymes and how it help obesity & diabetes? JOSHUA CORONA JOSHUA CORONA 11 months ago WOW! VERY TECHNICAL, BUT CLEARED TO UNDERSTAND 1 Joe Silkwood Joe Silkwood 7 months ago This Guy has a gift of explaining things!! Katrina Johnson Katrina Johnson 4 months ago What the heck, how did i understand all that?! Thanks for the lesson Dr Mike. That was Brilliant 2 Dr Matt & Dr Mike ここあ.丸かじり ここあ.丸かじり 7 months ago 生物の講義を聴きながらリスニング対策もできるという神授業 Andrew Bliss Andrew Bliss 9 months ago Supplements NAD, NR, NMN, NAD+, NADH…. all ultimately doing the same thing? Any of these the better choice? 2 Jocelyn Joseph Jocelyn Joseph 7 months ago (edited) Thank you🌹.it's easier to understand when the marker and white board is used since we get time to see and grasp what is explained. 1 Jason Sasman Jason Sasman 10 months ago HOw did he make something so complex........seem so simple!?!? And his bicep gains is amazing! Well done Doc! 2 Zakir Zak Zakir Zak 1 year ago Thank you 🙏... very good explanation 1 danjbro danjbro 9 months ago (edited) Rewatching! 👀 Current graduate student that has had a 10 year gap between undergraduate and now - never hurts to brush up on the basics. And guns! 😆 1 Dr Matt & Dr Mike Puranjay Jadeja Puranjay Jadeja 5 months ago Hi Dr.Mike, wanted to know what finally happens to NADH, is it eliminated or recycled ? ecwilliams777 ecwilliams777 3 months ago This doctor actually looks like someone I would listen to about health. I look at most doctors and I'm like "nope, you look disgusting and very unhealthy. Not listening to anything you try and tell me" 1 Cole Young Cole Young 6 months ago I’ve have never seen one of your videos, Nice job breaking it down. Thank You! Drew Drew 1 year ago Excellent video! I take NAD+ as a supplement! According to many studies, it is likely to be beneficial in human longevity! 2 Amina Kaja Amina Kaja 9 months ago Wowza, loved this video and the great explanation! 😊 3 정만지 정만지 1 year ago Can human manufacture the NADH artificially in vitro? Could we eat NADH by the form of a pill? My son can't metabolize long chain fatty acid because of a lack of long-chain acyl-CoA dehydrogenase. 1 Brendan O Brendan O 3 months ago I have questions on increasing out nitrogen uptake. How may I submit my questions please? Edward Bennett Edward Bennett 7 months ago Best explanation I’ve see yet 2 Eden Sun Eden Sun 3 months ago PERFECT explanation Barbie Cardenas Barbie Cardenas 11 months ago LOVE IT ;) you make me feel awesome thank you :) RA6162 RA6162 10 months ago (edited) It a DAM ! A reservoir of Proton (water) is made to travel down from high concentration (reservoir) down to a low concentration (below the dam), and in the process ATP is produced (Electricty from the turbine in case of a DAM using water) ! - Dr Mike you are a Genius ! 1 Dr Matt & Dr Mike Ali Al Attar Ali Al Attar 6 months ago hope you do more biochem vedios ,cz its really help 2 Shamsul Shamsul 6 months ago It was so easy and amazing concept based, I wanna know why 1 proton not hogging its letting free? Robert Novoa Robert Novoa 8 months ago (edited) How about "NMN" 🥦 supplement along with resveratrol 🍇 supplements, isn't this a faster way?🙄 1 Ben B Ben B 1 year ago Excellent! Thank you 1 Deborah Davis Deborah Davis 11 months ago I am curious to know if all that energy is transformed into a manageable non-anxious energy or if it creates more anxious energy for a person that already has anxiety. I've tried a lot of therapies that just increase my anxious energy....although it gave me more energy. I couldn't handle the increased anxiety that came with it, so I stopped trying. This was very helpful information. Thank you. Hassan Malik Hassan Malik 7 months ago I have 3 weeks study carbs and i dont understand this until in found this video , thankssssss 🥳🥳 1 Tessa Cyclone Tessa Cyclone 2 months ago (edited) How do we first make NAD ? So that it's floating through the body as you said at 0:46 Tenbite Ermias Tenbite Ermias 1 month ago You explained briefly thanks MARTZ MARTZ 5 months ago i like to be those electrons.. be hugged.. just kidding. thanks for this lecture, its helping me understand more the processes involved in cellular respiration and more.. Fat Moogle Fat Moogle 9 months ago I know you used glucose as an example, but what if you are doing keto and using fat as your fuel? Does it work the same way? 1 BTS Niki BTS Niki 2 months ago Thank you so much! 1 area859 area859 3 months ago Continuous replenishment of NAD promotes the proliferation and survival of fast-dividing cancer cells because elevated NAD levels enhance glycolysis via glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase (LDH) that require NAD as a co-enzyme (12, 13).Dec 12, 2018 P. Godwin P. Godwin 9 months ago Great info 💪🏼💪🏼 1 KatynMermaid 187 KatynMermaid 187 3 months ago 0:55 Is the H in NADH positive- I mean, does the NAD snatch the two elections like in an ionic bond and the the H is actually an H+ just hanging on the anion NAD -? Darth Swahl Gaming Darth Swahl Gaming 8 months ago Doc lookin jacked and jacked on science too. Love it! Thanks for the info 3 althaf althaf 7 months ago Very very useful video sir 1 Joni Svanidze Joni Svanidze 4 months ago ძალზედ სასსსიამოვნო მოსასმენი იყო მაიკ კაი კაცი ხარ <3 wampastompastomp wampastompastomp 6 months ago now I finally know where that H and e- come from to add to NAD Anne williams Anne williams 2 months ago Young individuals should take Resveratrol at night while older people should take it midday for the greatest effectiveness. If you’re 40 or above, I suggest you to take NMN. Just so you know, Resveratrol is needed to activate the sirtuin genes (which protect our DNA and epigenome), while NMN is needed to fuel the sirtuins. However, resveratrol is difficult to be absorbed by the gut, and the little resveratrol that ends up in the body is broken down very quickly. I take NMN Vitruvin brand for the first time, and so glad it didn't fail me. Nameless Blob Nameless Blob 1 year ago This man can split me in half. Sploosh 2 Ishan Ishan 5 months ago Already knew all this but what the hell he has got them gains 1 badmoon rising badmoon rising 3 months ago So why is NAD+ better then sugar. Does it not have all the bad effects of sugar? If not, how. N02tradamus N02tradamus 1 year ago How does lactate connect in this chain? Yaw Desmond Yaw Desmond 10 days ago Today salvation came to my home🥺,,, wooow❗ 1 Justin Cody Justin Cody 1 year ago 3 months of NAD IV Therapy and micronutrients now and zero complaints! First 8 weeks - 1x a week. Now once a month. 2hr drips . 😎💪✨💫 Jane Roth Jane Roth 1 month ago I take B Complex if I take NAD would I overdose since B Complex contains B3? Buddy Jenkins Buddy Jenkins 7 months ago Thought this was about NAD HIFI equipment. 1 Martin Tippins Martin Tippins 5 months ago So NADH gives away 3 electrons and four protons? Then what are you left with? I don't get it. Yasmin Sierra Yasmin Sierra 1 year ago You're the best 2 Bob Lemon Bob Lemon 6 months ago Yes, nice Job. You should be a teacher. A. Mansla A. Mansla 8 months ago (edited) Is it true that NAD is too big that bodies can't absorb?? NmN is better?? 1 Cynthia Monêt Cynthia Monêt 6 months ago Is it safe to take while pregnant? Tapan Kumar Samanta Tapan Kumar Samanta 7 months ago You are great 1 Smokey Joe Smokey Joe 7 months ago I am an idiot so please excuse my ignorance. I watch another video a Dr. demonstrates an NAD drip on himself and says he feels the effects immediately. This all happens instantaneously? No delay? dodo dodes dodo dodes 11 months ago ok that shows how you make NADH from NAD+ but what then when I have alot of NADH and need NAD+ now what 2 Jennyshane Spitler Jennyshane Spitler 5 months ago NAD? Is that good for diabetes and bad cholesterol? Lambo 1221 Lambo 1221 3 months ago I hear nad is like the limitless pill Γιωργος Παπας Γιωργος Παπας 3 months ago Is 200mg NAD+ ok daily?? Codex from Tiktok Codex from Tiktok 3 weeks ago How does NMN turn to NAD+ Quốc Thái Quốc Thái 3 months ago thank you! Lyna Berr Lyna Berr 8 months ago You are the best : ( 1 rodneysfishtank rodneysfishtank 1 month ago Best video ever Daily Dose of Medicine Daily Dose of Medicine 1 year ago 👏👏 햄ㅈㅣ네애옹. 햄ㅈㅣ네애옹. 5 months ago holy, doc might make a lot of energy on your arm, phone new phone new 2 months ago What happens to the protons one they re-enter the cell? Prabhsimran Singh Prabhsimran Singh 2 weeks ago Verrrrry goood Dr. Mike. Verrrry good. Rich Szabo Rich Szabo 4 months ago Biceps too distracting 😂 sick gains sir ismail elghuwael ismail elghuwael 6 months ago amazing The Madlad Prince The Madlad Prince 8 months ago I'm surprised the marker doesn't break Rudy Uribe Rudy Uribe 9 days ago What stack is doc on, his arms are huge!! Jennyshane Spitler Jennyshane Spitler 5 months ago Niacin B3? Is the same? a comedian a comedian 1 year ago u just amazing 😍 1 danjbro danjbro 9 months ago Doc's got guns! 1 Dr Matt & Dr Mike Helia Helia 3 months ago Thank you sarah holtss sarah holtss 2 months ago 🙏🙏🙏 1 Elvira Tarskaya Elvira Tarskaya 3 months ago My company sells now NAD+ Mikowacomet Mikowacomet 3 months ago you speak as if your theory of cellar biology was proven true. the majority of peer reviewed science is wrong, that's proven. aaron wells aaron wells 11 months ago All I heard was ahhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh Hot knight 13 Hot knight 13 3 months ago Is niacin the same as NAD? Jonathan Enciso Jonathan Enciso 8 months ago Dropping this comment just to say no idea why this video was recommended but uh yeah. Bye now Wayne Richardson Wayne Richardson 2 months ago As clear as mud Alex Belarus Alex Belarus 8 months ago didn't know that Paul Van Dyke is a doctor, Skunk Works G.I Joe Customs Skunk Works G.I Joe Customs 7 months ago Can you get these are home? معاذ طه سرحان معاذ طه سرحان 7 months ago ♥️ T Tendean T Tendean 6 months ago ...this channel is so *chef's kiss*. MM B MM B 3 months ago Could your shirt be any tighter? Akshitha Ch Akshitha Ch 1 year ago Handsome guy!! with awesome mind!! 1 Stark 3001 Stark 3001 1 year ago How can I focus on the board when he is in front of mr •InSide• •InSide• 7 months ago Why is this video always on my youtube screen? ;-; Beautiful pak pk Beautiful pak pk 9 days ago 2H+ Cog in the wheel Cog in the wheel 7 months ago Borrow your 11 yr olds shirt for this video? BananaPie BananaPie 1 year ago Dr Adrien Brody Dr.Ro3e Dr.Ro3e 3 months ago 🤔 B L B L 10 months ago I think his little boy is missing his shirt. 2 Erik S Erik S 10 months ago (edited) You should buy better fitting shirts. NAD+/NADH Mechanism & Coenzyme Chemistry 42,973 viewsJul 12, 2018 684 DISLIKE SHARE DOWNLOAD CLIP SAVE Molecular Memory 18.4K subscribers Why are coenzymes important to proteins? Dr. KP takes a look at the coenzymes NAD+/H and NADP+/H, explains how the structure allows for amazing chemistry to occur, and shows arrow pushing mechanisms for NAD+ and NADPH. Featured playlist 10 videos Biochemistry Videos Molecular Memory 31 Comments rongmaw lin Add a comment... Rakshith M Rakshith M 3 years ago (edited) AWESOME! You are one of the best teachers... 1 Molecular Memory Sk8ter Girl Sk8ter Girl 1 year ago THANK YOU SO MUCHHHH YOU ARE THE BEST TEACHER EVER!!!!!! You explained it very clearly and I love your energy!!!!! Thank you again Molecular Memory A Fenaoui A Fenaoui 2 years ago Thank you for your explanation. This helps me a lot to do electron pushing and to spot - electron sinks- 3 Mariam Mohammed Mariam Mohammed 1 year ago Thank so much from the bottom of my heart 👏👏👏👏👏👏👏👏👏👏👏 U just made biochemisty concepts so ridiculously trivial 😄👏🤍 Laone Patrice Segootsane Laone Patrice Segootsane 2 months ago (edited) Thank you so much Ma'am... This is so helpful and i enjoy your art of teaching very much! Bijayananda Nayak Bijayananda Nayak 2 years ago Thanks a lot mam for this useful information 🥰🥰 1 Omer Feldman Yofiël Omer Feldman Yofiël 5 months ago Great teaching style ❤️ AffordYourNuance AffordYourNuance 3 years ago Hi! I just came across this channel. I am currently an accountant but I am back in school because pursuing a career in science seems much more fulfilling to me. I have a question, is your understanding at a level such that you look at organic molecules and functional groups and know what reactions will/can occur? Or is it that you deeply understand certain sets of reactions from seeing them over and over? Also, do you have any recommendations on how to develop an unconscious competence in this area ahead of my studies? Thanks! 1 carlosagc carlosagc 2 years ago Are you going to talk about fad/fadh2? Beta oxidation of different types of fat? =) Molecular Memory Zakir Zak Zakir Zak 1 year ago Very good explanation...thank you TommyJMaylee3141 TommyJMaylee3141 3 years ago Excellent info! Subscribing 1 Molecular Memory Prem Shing Prem Shing 1 year ago Thank u so lately but.. Eady to understand u really help me with your knowledge pityo gonzalez pityo gonzalez 3 years ago Wow, awesome.!!! 정만지 정만지 1 year ago (edited) Can human manufacture the NADH artificially in vitro? Could we eat NADH by the form of a pill? My son can't metabolize long chain fatty acid because of a lack of long-chain acyl-CoA dehydrogenase. joseph lozoponi joseph lozoponi 1 year ago can i use NADH instead of NMN. i cant afford NMN. i am a retired senior citizen. there are a number of companies selling NADH much cheaper than NMN. Please reply. 1 BoBu BoBu 2 years ago But how can NAD+ oxidise? It already has a positive charge, does it magically synthesise electrons out of nowhere? If oxidation is te be defined as the process of a reductor becoming an oxidator then shouldn't it be able to give away electrons? Shazma Naseeb Shazma Naseeb 1 year ago Can someone tell me about the nature of NAD+??? sonu khare sonu khare 3 years ago I am taking nadh for cfs . How does nadh helps with chronic fatigue syndrome? Please help Rehana Shabir Rehana Shabir 1 year ago Thanks too much mam☺️💕😘 ناصر المعصلي ناصر المعصلي 2 months ago لماذا الفيديوهات غير واضحة حتى نستفيد منها اكثر Chris Hardin Chris Hardin 1 year ago When hydride attacks the carbocation it has two electrons. One electron bonds to carbon, But where does the other electron go? Wolf Duranti Wolf Duranti 2 years ago You great, But if this vedio had been about food or nonsense add, you would have millions of viewers. Accept my condolences dear Dr.Ro3e Dr.Ro3e 3 months ago TNQ! Danilo Ceja Danilo Ceja 1 year ago Hi 1 id="pRf3x1wEFq4" width="320" height="266" src="https://www.youtube.com/embed/pRf3x1wEFq4"> Liew Liew 8 months ago