Book Review on : LLifespan: Why We Age―and Why We Don't Have To

Lifespan: Why We Age―and Why We Don't Have To Hardcover – Illustrated, September 10, 2019 by David A. Sinclair PhD (Author), Matthew D. LaPlante (Author) 4.6 out of 5 stars 7,775 ratings Goodreads Choice Award nominee See all formats and editions Kindle $14.99 Read with Our Free App Audible Logo Audiobook $0.00 Free with your Audible trial Hardcover $15.99 92 Used from $7.79 33 New from $11.94 1 Collectible from $34.60 A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it. Read more Print length 432 pages Language English Publisher Atria Books Publication date September 10, 2019 Next page The Amazon Book ReviewThe Amazon Book Review Book recommendations, author interviews, editors' picks, and more. Read it now Frequently bought together Lifespan: Why We Age―and Why We Don't Have To+The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer+How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease Total price:$46.99 Add all three to Cart Some of these items ship sooner than the others. Show details This item: Lifespan: Why We Age―and Why We Don't Have To by David A. Sinclair PhD Hardcover $15.99 The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer by Dr. Elizabeth Blackburn Hardcover $13.99 How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease by Michael Greger M.D. FACLM Hardcover $17.01 Products related to this item Sponsored Page 1 of 157Page 1 of 157 Previous page of related Sponsored Products Never Binge Again(tm): How Thousands of People Have Stopped Overeating and Binge Eating - and Stuck to the Diet of Their Choice! 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Ilchi Lee Radically rethink your ideas on aging, health, personal fulfillment, and what's possible in your lifetime. 569 Paperback $17.96 Next page of related Sponsored Products Customers who viewed this item also viewedPage 1 of 15Page 1 of 15 Previous page The Longevity Diet: Slow Aging, Fight Disease, Optimize Weight The Longevity Diet: Slow Aging, Fight Disease, Optimize Weight Valter Longo 4.4 out of 5 stars 1,611 Paperback $14.69 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer Dr. Elizabeth Blackburn 4.5 out of 5 stars 1,246 Hardcover $13.99 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Only 1 left in stock - order soon. Lifespan [Hardcover], The Telomere Effect, How Not To Die 3 Books Collection Set Lifespan [Hardcover], The Telomere Effect, How Not To Die 3 Books Collection Set Dr David A. Sinclair 4.7 out of 5 stars 101 Paperback $39.90 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Summary & Analysis of Lifespan: Why We Age—and Why We Don't Have To | A Guide to David Sinclair's Book Summary & Analysis of Lifespan: Why We Age—and Why We Don't Have To | A Guide to David Sinclair's Book SNAP Summaries 4.4 out of 5 stars 218 Paperback $6.99 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Next page Popular Highlights in this book What are popular highlights? Previous page Today, analog information is more commonly referred to as the epigenome, meaning traits that are heritable that aren’t transmitted by genetic means. Highlighted by 2,711 Kindle readers They have also evolved to require a molecule called nicotinamide adenine dinucleotide, or NAD. As we will see later, the loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old but not when we are young. Highlighted by 2,621 Kindle readers Youth → broken DNA → genome instability → disruption of DNA packaging and gene regulation (the epigenome) → loss of cell identity → cellular senescence → disease → death. Highlighted by 2,491 Kindle readers The longevity genes I work on are called “sirtuins,” named after the yeast SIR2 gene, the first one to be discovered. There are seven sirtuins in mammals, SIRT1 to SIRT7, and they are made by almost every cell in the body. Highlighted by 2,436 Kindle readers Next page Editorial Reviews Review “Lifespan is entertaining and fast-paced—a whirlwind tour of the recent past and a near future that will see 90 become the new 70. In a succession of colorfully titled chapters (‘The Demented Pianist’, ‘A Better Pill to Swallow’), Sinclair and LaPlante weave a masterful narrative of how we arrived at this crucial inflection point.” ― Nature Journal “Sinclair’s work on slowing the aging process, and even reversing some aspects of it, could lead to the most significant set of medical breakthroughs since the discovery of antibiotics nearly a century ago.” ― Sydney Morning Herald "In this insightful and provocative book that asks questions about how we age, and whether humans can overcome decay and degeneration, Sinclair grapples with some of the most fundamental questions around the science of aging. The result is an elegant and exciting book that deserves to be read broadly and deeply." -- Siddhartha Mukherjee, Pulitzer Prize–winning and #1 New York Times bestselling author “There are few books that have ever made me think about science in a fundamentally new way. David Sinclair’s book did that for me on aging. This is a book that anyone who ages must read.” -- Leroy Hood, PhD, professor at the California Institute of Technology, inventor, entrepreneur, member of all three US National Academies, and co-author of Code of Codes “If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100 plus years, then David Sinclair’s new book Lifespan, which reads like a detective novel, will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant.” -- Mark Hyman, MD, director of the Cleveland Clinic Center for Functional Medicine and #1 New York Times bestselling author “This is the most visionary book about aging I have ever read. Seize the day—and seize this book!” -- Dean Ornish, MD, founder and president of the Preventative Medicine Research Institute and New York Times bestselling author of UnDo It! “In Lifespan, David Sinclair eloquently tells us the secret everyone wants to know: how to live longer and age slower. Boldly weaving cutting-edge science with fascinating bits of history, sociology, and morality, Sinclair convinces us that it is not only possible to live beyond one hundred years, it is inevitable that we will be able to one day do so. If you are someone who wants to know how to beat aging, Lifespan is a must-read.” -- William W. Li, MD, New York Times bestselling author of Eat to Beat Disease “For years, the aging field has been about vitamins, juicebars, and snake oil. Now, in a seminal book, Harvard Professor David Sinclair has changed the landscape: he has combined precise science, practical translation, and autobiography to produce a rare book that is insightful, inspiring, and informative. He has translated a wealth of molecular detail into a program that we can all use to live longer and healthier. This is part of the ongoing revolution in aging and chronic disease, and there is no one who is better suited to write such an authoritative book than David Sinclair. For anyone interested in understanding the aging process, living longer, and avoiding the diseases of aging, this is the book to read.” -- Dale Bredesen, MD, New York Times bestselling author of The End of Alzheimer's “A visionary book from one of the most masterful longevity scientists of our time. Lifespan empowers us to change our health today while revealing a potential future when we live younger for longer.” -- Sara Gottfried, MD, New York Times bestselling author of The Hormone Cure “Prepare to have your mind blown. You are holding in your hands the precious results of decades of work, as shared by Dr. David Sinclair, the rock star of aging and human longevity.” -- Dave Asprey, founder and CEO of Bulletproof and New York Times bestselling author of The Bulletproof Diet “Imagine a world in which we can live long enough to meet not just our grandchildren, but our great-grandchildren. This is Sinclair’s vision for the future of humankind, a vision that looks to science, nature, history, and even politics to make the case that it is possible to live well into our hundreds. Lifespan is boldly leading the way.” -- Jason Fung, MD, author of The Diabetes Code and The Obesity Code “I have had the pleasure of knowing Dr. David Sinclair and following his groundbreaking research into the causes and reversal of aging for many years. In Lifespan, David takes us on an entertainingly wild ride into both the author’s fascinating personal journey of discovery and his seminal research into why we age. But more importantly, he provides us with the everyday tools that we can all use to stop what he now calls ‘the disease of aging.’. . . You owe it to yourself and your loved ones to read and follow his advice, as I have for the last 15 years!” -- Steven R Gundry, MD, New York Times bestselling author of The Longevity Paradox and medical director of the International Heart and Lung Institute “David Sinclair masterfully presents a bold vision of the future in which humanity is able to slow or reverse the aging process and live younger, healthier lives for longer. He engages the reader in a thorough examination of the science and emerging technologies that will enable humanity to achieve this vision.” -- Victor J. Dzau, MD, president of the US National Academy of Medicine and CEO of Duke University Medical Center “Lifespan is the book we have been waiting for. It transcends everything we know about aging and longevity—a combination of brilliant scientific work, a pioneering mind, and the dream for a longer, healthier and happier life. Lifespan provides a vision for our future and the roadmap on how to get there, merging scientific breakthroughs and simple lifestyle changes to not only help us feel younger, but actually become younger.” -- Naomi Whittel, New York Times bestselling author of Glow15 “I have written about the brilliant work of David Sinclair for over fifteen years and have watched his life’s mission of using science to slow the scourge of old age and dying move from the outer edge to more mainstream biology (he’s still pushing boundaries!) as his careful work in the lab has steadily shed light on how the mechanisms of aging work in humans and in other organisms. In Lifespan, the full force of his optimism, humor, and soft-spoken eloquence as a storyteller-scientist come through. I was charmed and delighted by his skill at blending his own life’s narrative and others’ with clear and levelheaded explanations of some very complex and emerging science. I’m hoping we have David Sinclair with us and doing his science and writing books for another 500 years, give or take a century.” -- David Ewing Duncan, award-winning journalist, bestselling author, and curator of Arc Fusion “Lifespan gives us hope for an extraordinary life. As the brilliant Dr. David Sinclair explains, aging is a disease, and that disease is treatable. This eye-opening book takes you to frontlines of incredible breakthroughs. What could be more valuable than an extended health lifespan? Enjoy this must read masterpiece!” -- Peter H. Diamandis, MD, New York Times bestselling author of Abundance and Bold “David is a pioneer poised to change how we think about and understand aging.” -- Stephanie Lederman, CEO of the American Federation for Aging Research (AFAR), New York “The most important message and priority of our time. For years to come, humanity will reflect on this book with awe and respect. Read it. . . . Your life depends on it.” -- Marc Hodosh, former owner & co-creator of TEDMED “A tour de force. Sinclair’s book, and his life’s work ranks with humanity’s greatest contributions to helping enhance the joy and happiness of life, ranking with the works of Jenner, Pasteur, Salk, Locke, Gandhi, and Edison. Lifespan is a groundbreaking literary triptych that expertly combines the science of living longer, a practical checklist to unleash our inner potential for healthy longevity, and a brilliant philosophical, policy and ethical synthesis. A masterpiece.” -- Martine Rothblatt, founder, Chairwoman of the Board, and CEO of United Therapeutics and creator of SiriusXM Satellite Radio “Stepping on the moon changed humanity. In Lifespan, Sinclair takes the ultimate step for humanity that will transform our lives beyond anything we could ever have imagined. If you can put your deepest beliefs aside, this will be the most important book you will ever read. The author is bold, the science is profound, and our future is here.” -- Henry Markram, PhD, professor at EPFL, Switzerland, director of the Blue Brain Project, and founder of Frontiers open-access journals “An intellectually fascinating book with tantalizing insights on the most important issue about yours and everyone’s future.” -- Andrew Scott, PhD, professor of economics at London Business School and author of The 100-Year Life “Throughout the book, the author’s enthusiasm jumps off the page.” ― Kirkus Reviews “Sinclair’s dedication to understanding aging on both a microscopic and global scale is bound to shatter centuries of paradigms.” ― Scientific Inquirer “The book, which surpasses everything we know about aging and life extension, has been written with a rich literary material of impressive depth and clarity to offer a deeper understanding of genetics and human longevity research.” ― Wall Street Pit “Brilliant and enthralling." —Wall Street Journal About the Author David Sinclair, PhD, AO, is a professor of genetics at Harvard Medical School. One of the leading innovators of his generation, he has been named by Time as “one of the 100 most influential people in the world” and top fifty most influential people in healthcare. He is a board member of the American Federation for Aging Research and has received more than thirty-five awards for his research and major scientific breakthroughs. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others. To learn more, visit LifespanBook.com and follow him on Twitter @DavidASinclair. Matthew LaPlante is an associate professor of journalistic writing at Utah State University, where he teaches news reporting and feature writing. A former US Navy intelligence specialist and Middle East war correspondent, he is the author of Superlative: The Biology of Extremes and the cowriter of multiple other books on the intersection of science and society. He lives in Salt Lake City and skis in Big Cottonwood Canyon. To learn more, visit MDLaPlante.com and follow him on Twitter @MDLaPlante. Read more Start reading Lifespan: Why We Age—and Why We Don't Have To on your Kindle in under a minute. Don't have a Kindle? Get your Kindle here, or download a FREE Kindle Reading App. Product details Publisher ‏ : ‎ Atria Books; Illustrated edition (September 10, 2019) Language ‏ : ‎ English Hardcover ‏ : ‎ 432 pages ISBN-10 ‏ : ‎ 1501191977 ISBN-13 ‏ : ‎ 978-1501191978 Item Weight ‏ : ‎ 1.35 pounds Dimensions ‏ : ‎ 6 x 1.3 x 9 inches Best Sellers Rank: #1,254 in Books (See Top 100 in Books) #2 in Genetic Health #2 in Genetics (Books) #8 in Longevity Customer Reviews: 4.6 out of 5 stars 7,775 ratings Videos Videos for this product 2:13 BOOK REVIEW: Lifespan -why we age and why we don’t have to Robert Lufkin MD Amazon Influencer Store Upload your video About the author Follow authors to get new release updates, plus improved recommendations. Follow David Sinclair David A. Sinclair, Ph.D., A.O. is one of the world’s most famous and influential scientists, known for his work on controlling the aging process. He is a tenured Professor at Harvard Medical School and TIME magazine named him “one of the 100 most influential people in the world” (2014) and among the “Top 50 People in Healthcare” (2018). His newsletter is at www.lifespanbook.com and you can follow him on Twitter @davidasinclair or IG at davidsinclairphd. He has a top healthcare podcast series called Lifespan. David is on the board of directors of the American Federation for Aging Research and has received more than thirty-five awards for his research and is an inventor on 40 patents. Dr. Sinclair has been featured on The Joe Rogan Experience, 60 Minutes, a Barbara Walters special, The Today Show, Good Morning America, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others. After thirty years of searching for truths about human biology, David is in a unique position. If you were to visit him in Boston, you’d most likely find him hanging out in his lab at Harvard Medical School, where he's a professor in the Department of Genetics and CoDirector of the Paul F. Glenn Center for Biological Mechanisms of Aging Research. He also runs a sister lab at his alma mater, the University of New South Wales in Sydney. In his labs, teams of brilliant students and PhDs have both accelerated and reversed aging in model organisms and have been responsible for some of the most cited research in the field, published in some of the world’s top scientific journals. He is also a cofounder of the journal Aging, which provides space to other scientists to publish their research on one of the most challenging and exciting questions of our time. He's also a cofounder of the Academy for Health and Lifespan Research, a group of the top twenty researchers in aging worldwide. In trying to make practical use of his discoveries, he has helped start a number of biotechnology companies and sits as chair of the scientific boards of advisers of several others. These companies work with hundreds of leading academics in scientific areas ranging from the origin of life to genomics to pharmaceuticals. He is, of course, aware of his own lab’s discoveries years before they are made public, but through these associations, he is also aware of many other transformational discoveries ahead of time, sometimes a decade ahead. Having received the equivalent of a knighthood in Australia and taken on the role of an ambassador (hence the AO at the end of his name), he's been spending quite a bit of his time briefing political and business leaders around the world about the ways our understanding of aging is changing—and what that means for humanity going forward. David is committed to turning key discoveries into medicines and technologies that help the world. He is involved in a variety of activities beyond being an academic including being a founder, equity owner, adviser, member of the board of directors, consultant, investor, collaborator with, and inventor on patents licensed to companies working to improve the human condition or national security. For an updated list of activities, see https://genetics.med.harvard.edu/sinclair/. 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Quick and easy recipes for your everyday life. 6 Paperback $14.99 Next page of related Sponsored Products Sponsored How would you rate your experience shopping for books on Amazon today? Very poor Neutral Great Customer reviews 4.6 out of 5 stars 4.6 out of 5 7,775 global ratings 5 star 74% 4 star 16% 3 star 6% 2 star 2% 1 star 2% How customer reviews and ratings work Review this product Share your thoughts with other customers Write a customer review Sponsored Reviews with images Customer imageCustomer imageCustomer imageCustomer image See all customer images Read reviews that mention david sinclair joe rogan must read well written longer and healthier cutting edge highly recommend aging as a disease great book life changing anti aging years ago healthy life global warming health span amino acids second half aging process subject matter eye opening Top reviews Top reviews Top reviews from the United States R. Cronise 5.0 out of 5 stars He changed my life. Let him change yours. Reviewed in the United States on September 15, 2019 Verified Purchase As one of the pioneers in longevity research, David challenged status quo and demonstrated that nature’s longevity genes seemed to be conserved throughout biology. This is good news, because the changes that occur with aging seem to be correctable later in life. This isn’t another self-help book with meal plans and shopping lists. Instead, it will guide you through the real challenges and progress on our path to not just living longer, but importantly, living healthier. Although this is plenty technical, it’s not an academic tome. Anyone, researcher or layman alike, will be able to follow the story thanks to the inclusion of so many personal accounts and reflections. After finishing, you will have a new perspective and hopefully realize that we have the ability right now to extend healthspan and the very real possibility of extending lifespan in the coming decade. We met in 2009 and he encouraged me to write collaborative journal articles (metabolic winter hypothesis and oxidative priority) and now that work ultimately is the basis for our book, The Healthspan Solution, which focuses more on what we can achieve with diet. It’s been an honor working with him and having a man of his insight as a mentor and friend. Customer imageCustomer image 361 people found this helpful Helpful Report abuse Timothy D. Lundeen 5.0 out of 5 stars All about healthy life extension, by a leading scientist Reviewed in the United States on September 17, 2019 Verified Purchase . David makes three critical points: * longer healthy lifespan improves all of our lives, not just personally, but for all of the people we love * mechanisms to increase lifespan are part of our cells and often just need to be activated * increasing healthy lifespan will not make the world overcrowded, but will benefit everyone by increasing productivity and overall well-being All of these are well-supported and convincing, including touching and memorable personal experiences. I do have one major issue, though. Our current medical system is focused on the bottom line, making money is more important than the best protocol. Look at Vioxx, for example, which killed thousands of people so that Merck could make more money. David has personal experiences with the system: his Mom almost died from poisoning by prescription medicine, and his daughter could have died from a serious Lyme infection that was not properly handled. Yet David accepts that vaccination is a medical miracle, without doing any research on its risks and benefits. I hope he will take a serious look at all the issues: * the extremely high rates of chronic illness in vaccinated vs non-vaccinated children, The Children’s Health Defense has a good series based on peer-reviewed research * the connection between aluminum and autism, with artists having the highest levels. See Dr Chris Exley’s peer-reviewed work. Most vaccines have high levels of aluminum that has been shown to stay in the body and migrate to the brain * the connection between vaccination-induced brain inflammation and brain injury, see vaccine papers dot org, which includes full-text copies of peer-reviewed research: "powerful scientific evidence has emerged indicating that vaccines cause brain injury such as autism, epilepsy, schizophrenia, depression, attention-deficit disorder and other mental illnesses. This scientific evidence has been largely ignored by the media, and by medical institutions that are supposedly guided by science." * the actual history of vaccination. Medical historians estimate that ALL of modern medicine, including vaccination and antibiotics, reduced childhood mortality by 4-6%. That is, 94-96% of the reduction was from improved sanitation and nutrition. For example, scarlet fever has been eradicated — without any vaccine. A good source is the book Dissolving Illusions. * the actual contents of vaccines as analyzed by Corvelva, showing high levels of contamination * the lack of liability for vaccines by the medical industry. Instead, a government fund compensates injuries, and has paid out over $4 billion. This does not motivate safer vaccines! Read more 320 people found this helpful Helpful Report abuse Kindle Customer 3.0 out of 5 stars Meh - not much actionable except for a single page Reviewed in the United States on October 3, 2019 Verified Purchase Dr. Sinclair has been doing the podcast rounds and you can learn a lot more from those podcasts about his research than you can from this book. The book itself is full of anecdotes and socio-political-economic idea;, it might be useful as an introduction for those flirting with the idea of life extension, but this book isn't for those who are already interested in it. There's one page in the "Conclusion" section where he mentions what he does which is a 1g NMN, 1g resveratrol, Vitamin D, K2, 83mg aspirin, avoid sugar, bread, pasta, skip one meal a day, get your blood tested, don't smoke, avoid plastic, excessive UV exposure, X-Rays, CT scans, sleep in a cold bedroom, do cold exposure, do exercise. 2,495 people found this helpful Helpful Report abuse Ben 5.0 out of 5 stars One of the most important books ever written Reviewed in the United States on September 12, 2019 Verified Purchase I've been following Dr Sinclair for some time and have always been impressed by his ability to explain the most complex science to us commoners. But I didn't truly grasp the breadth of different science he is involved in until now. The breakthroughs they are making now is astounding, and the speed they are occuring is dramatic. But that is just the tip of the iceberg once he (and others) convince the policy makers to treat aging as a disease and fund the research. It has the potential to stop nearly all chronic disease, so the efforts should be increased 1000x times, or more. I believe this will happen soon, and this book may be a significant factor in the dawning of a new era for humankind. Dr Sinclair is a visionary with the ability to truly change the world. 180 people found this helpful Helpful Report abuse T. S 4.0 out of 5 stars Useful, if you know a bit of cell biology Reviewed in the United States on September 11, 2019 Verified Purchase I am reading and am continuing to read. This book is important. But one would need a basic education in cell biology to completely understand what the author is talking about. Page 5 has a couple of paragraphs where out of nowhere, the author starts talking about “DNA, gene, genetic material, cell division, chromosome, tumor”. If you have no clue what these are, you will have a hard time following the author. If you are like me (software engineer) I would urge you to learn about basic cell biology first and then read this book to fully appreciate it. If I were the author, I would definitely look at providing an introductory chapter on cell biology in the next edition (if the intended audience is lay people) 243 people found this helpful Helpful Report abuse David Weiseth 5.0 out of 5 stars One of the preeminent thought leaders in this space, ie longevity Reviewed in the United States on September 13, 2019 Verified Purchase I have two gurus I rely on for longevity advice, Sinclair and Longo, they actually offer two different approaches to the subject matter, but between the two you have a great lay of the land. This book is highly recommended, I am reading it now, very slowly to glean all I can, I have been waiting for this book's release for 6 months, finally the day has arrived. 102 people found this helpful Helpful Report abuse See all reviews Top reviews from other countries Honest Reviewer 3.0 out of 5 stars A book of two halves: the first part fascinating, the second... Reviewed in the United Kingdom on November 2, 2019 Verified Purchase Although the book is split into three sections - the past, the present and the future - it reads as two halves: what is essentially scientific and what is decidedly ethical. When Dr Sinclair confines himself to his subject, it very difficult to put the book down. He discusses the advances in genomics, etc, that led him and others to studying ageing, before discussing current research and the notion that ageing is more a disease than a natural process. He includes some scientific detail, a few useful analogies and a good smattering of anecdotes to impress and educate the reader, which, despite some obvious padding, he undeniably does. I think a typical scientist would and should stop right there; for science does not concern itself with morality but with pure knowledge whether constructive or destructive. Nonetheless, Dr Sinclair goes on to debate the real and political consequences of people living, if not forever, certainly much longer than they do now. To me, this is where the book rapidly goes down hill. Dr Sinclair knows there will be serious repercussions: an increase in population; a greater demand for resources; more pollution; more carbon emissions; etc, etc. He says that alongside the big increase in population in the 1800's was a huge increase in the standard of sanitation and health as though it were causative - more people lead to more benefits. He thinks that GMO and foods modified by other technologies will provide the solution to feeding the ever-increasing numbers of mouths and gets irritated when some people have the temerity to question their safety. Also, because he would be content to work doing his interesting research in his lab for the next 50 years, it does not mean a miner would like to spend another 50 digging coal. Despite Dr Sinclair's faith in the ingenuity of man, there are times when i sense he is trying to convince himself of his utopian vision rather than the reader. Living to infinity is not the be all and end all; living a healthy life is more important, whether one lives to 70 or 90. At some point I will re-read the first half of the book - which I enjoyed - but not the second. I must be only part Luddite. Read more 187 people found this helpful Report abuse Thomas Burgess 3.0 out of 5 stars Interesting. Not sure of the ethics. Reviewed in the United Kingdom on December 22, 2019 Verified Purchase Very interesting book. Destroys the paradigm that aging is natural and opens your mind to it being a disease (basically a failure in our genes.) Richard Dawkins touched on why we would inherit genes that fail as we age: essentially we reproduce before we suffer from these age-related ailments, and so natural selection has not filtered it out as it presumably has young man/woman ailments that would kill off the would-be reproducer. The book uses scientific terms and explanations and so some reading on physiology may be beneficial alongside this book. Note taking is a must if you're wanting to retain and be able to explain the contents. The reason I've given it 3 out of 5 stars is the completely lack of concern over the animals the author and his colleagues tested on. I know its commonplace (though this doesn't make it right) but there is not even any acknowledgement from the author that this is cruel behaviour. He will talk about how he'll age mice prematurely (yes fascinating but cruel), starve them, dissect them prior to natural death, etc. He does comment on how easy it is to buy mice to test on, though. Well, as long as subjecting unlucky animals to torture is convenient! Read more 150 people found this helpful Report abuse CI 5.0 out of 5 stars Fabulous! Reviewed in the United Kingdom on September 22, 2019 Verified Purchase Great book. Really interesting. Gives a glimpse of the future in terms of cutting edge gene therapy but also provides advice that anyone can implement now e.g. fasting, exercise, calorie restriction and certain supplements. Highly recommended. 45 people found this helpful Report abuse Stan 5.0 out of 5 stars Must read book Reviewed in the United Kingdom on September 20, 2019 Verified Purchase I am reading this book while traveling. It is better than I expected and deeply personal from David. I already know many of the topics the book is talking about but I find it very useful to consolidate my knowlege. The knowledge in this book is of enormous value and at the same time the book is low cost. I think it is the most important book I read this year. 32 people found this helpful Report abuse Lindsay Tideswell 5.0 out of 5 stars Thought provoking read Reviewed in the United Kingdom on October 15, 2019 Verified Purchase For someone who is not a Scientist or indeed aware of any of the issues in the book, this book is a must read if you are in the slightest bit interested in enjoying this wonderful life for as long as possible. It has certainly opened up my mind to what is possible and encourages you to look at our human bodies in a totally different way. I guess for experts a lot of the information is 'old hat' for me it proved to be the springboard to find out as much as I can about living longer and healthier. I hope to be a very well informed layman in 6 months time able to make some key decisions. Outstanding read. 31 people found this helpful Report abuse See all reviews Customers who bought this item also boughtPage 1 of 9Page 1 of 9 Previous page The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer Dr. Elizabeth Blackburn 4.5 out of 5 stars 1,246 Hardcover $13.99 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Only 1 left in stock - order soon. 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Why We Sleep: Unlocking the Power of Sleep and Dreams Why We Sleep: Unlocking the Power of Sleep and Dreams Matthew Walker 4.7 out of 5 stars 18,906 Paperback $10.29 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Next page Related to items you've viewedSee morePage 1 of 7Page 1 of 7 Previous page The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer Dr. Elizabeth Blackburn 4.5 out of 5 stars 1,246 Hardcover $13.99 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Only 1 left in stock - order soon. Lifespan [Hardcover], The Telomere Effect, How Not To Die 3 Books Collection Set Lifespan [Hardcover], The Telomere Effect, How Not To Die 3 Books Collection Set Dr David A. Sinclair 4.7 out of 5 stars 101 Paperback $39.90 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Why We Sleep: Unlocking the Power of Sleep and Dreams Why We Sleep: Unlocking the Power of Sleep and Dreams Matthew Walker 4.7 out of 5 stars 18,906 Paperback $10.29 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon NMN Nicotinamide Mononucleotide Supplements 250mg - Stabilized Form (60 Capsules), 99% Pure NMN Supplement Capsules for Incre NMN Nicotinamide Mononucleotide Supplements 250mg - Stabilized Form (60 Capsules), 99% Pure NMN Supplement Capsules for Increased NAD Levels, DNA Repair, & Healthy Aging, GMP Certified, Genex Formulas 4.4 out of 5 stars 1,438 Amazon's Choice in Vitamin B3 (Niacin) Supplements $41.50 ($0.69/Count) Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Mimic Fasting Recipes: The Fasting Mimicking Diet (FMD): Meal Plan + Fasting Guide. Over 30 Recipes and Exact Doses Mimic Fasting Recipes: The Fasting Mimicking Diet (FMD): Meal Plan + Fasting Guide. Over 30 Recipes and Exact Doses FIVE FRIENDS FOR FASTING 4.0 out of 5 stars 27 Paperback $19.97 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon Lifespan Why We Age and Why We Don’t Have To By Dr David A. Sinclair and 12 Rules for Life An Antidote to Chaos By Jordan B. Lifespan Why We Age and Why We Don’t Have To By Dr David A. Sinclair and 12 Rules for Life An Antidote to Chaos By Jordan B. Peterson 2 books Collection Set Dr David A. Sinclair 4.4 out of 5 stars 47 Paperback $21.70 Lifespan - David Sinclair, PhD (overview & thoughts) 15,935 viewsDec 28, 2019 The Sheekey Science Show 28.2K subscribers I recently read "Lifespan - Why We Age - and Why We Don't Have To" by David A.Sinclair PhD, so I have made a video summarising the key messages from the book and also my thoughts and opinions on it! It was hard to summarise everything in 12 mins without revealing too much from the book, so you should go buy and read the book for yourself! https://amzn.to/39ifQil Is Calorie restriction legit - https://youtu.be/0rH9fKukyGo Eric Topol - Deep Medicine (REVIEW) - https://youtu.be/B9VWNIzCJ5k Featured playlist 58 videos Hallmarks of aging The Sheekey Science Show 42 Comments rongmaw lin Add a comment... Dora The Illegal Alien Pinned by The Sheekey Science Show Dora The Illegal Alien 2 years ago you need a hell of a lot more subscribers and views 17 The Sheekey Science Show Robert Scott Robert Scott 1 year ago Dear Sheeky , I enjoyed Sinclair's book very much and your review is helpful. Sinclair is a serious researcher who has devoted his career to understanding the biology of ageing. But after reading Andrew J Steele's book "Ageless" and delving into the literature, partly with the help of your channel, I find Sinclair's perspective rather narrow. He claims to have found the theory of ageing, yet other researchers in the field seem to tell a more complicated story. The 2013 review article by Lopez-Otin et al., seems to be quite influential with over 7000 citations on Google scholar. They cite 9 halmarks of ageing, one of which is epigenetic alterations and seems to include Sinclair's work on sirtuins. In other words, perhaps epigenetics is important to ageing but there is much more too it. For example, one might ask how are pathways involving sirtuins going to help us live longer if we die of a heart attack or stroke because of increased blood pressure because the artery walls lost the flexibility to expand? 3 אנחנו מדברים פודקאסט אנחנו מדברים פודקאסט 7 months ago (edited) 1:30 Your cells getting old is like a cd which is new getting more and more scratched till it's not useable 3:30 Caloric restriction helps live longer 7:00 MMN is great drug 8:00 Exercise more. 8:1/ Go out the termonetural zone. Do cold shower Go outside when it's cold. Do sauna 10:30 Interesting 12:13 Old age is a diesase 3 Hollywoodiani it Hollywoodiani it 1 year ago Hi Eleanor! May I suggest you to read the book "Cracking the aging code" that presents a very original theory of aging that I found very compelling. It is not much about the biochemical mechanisms but more about the evolutionary underpinnings. That could be another video idea... 2 The Sheekey Science Show Deika Elmi Deika Elmi 2 years ago I loved this, you broke it down and made it easy to understand. Thank you! 5 The Sheekey Science Show G3orgianSoldier G3orgianSoldier 1 year ago I am a mathematician and have just made a presentation about Claude Shannon's works in my university. It's so cool to see it here :D 2 The Sheekey Science Show Jay Ahn Jay Ahn 1 year ago Thank you very much for the concise and artistic presentation. I liked also your English accent. 7 The Sheekey Science Show Intaek Kim Intaek Kim 1 year ago I bought the book and read the first part of it. Your concise video is very helpful in summarizing the book. Thank you! 1 The Sheekey Science Show bjorn2fly bjorn2fly 2 years ago Nice video, still a problem with the microphone, but better than last video. Also In many countries Metformin is without prescription. Also loved your last video on aging, pity you dont get a bigger audience here on youtube, but maybe you can live forever, now that you know so much about reversing ageing :-) 3 Scott Herford Scott Herford 2 years ago Thanks Sheeky, Lifespan is jampacked but really fascinating reading. 3 The Sheekey Science Show Larry Kraft Larry Kraft 1 year ago I’ve recently come across your channel and I’ve greatly enjoyed several of your videos. Thank you very much for the energy and time you have put into A, getting so smart and B, making such important information accessible to the rest of us! If I may make one suggestion (and please excuse me if you’ve already adopted this in later videos), could you please add like a 2 second pause whenever you get done building an image before jumping to a new image? For example, at about 4:45 in this video I had a hard time discovering what the final E in that acrostic was for. I finally had to slow it down to 1/4 speed to see that the final E in CALERIE (sic) was for “energy.” I look forward to watching your video on calorie restriction. For a good laugh take any speech from anyone and slow it to 1/4 normal speed. It makes them sound like they’re half asleep. Thanks again! The Sheekey Science Show Yusun Liu Yusun Liu 1 year ago After listening to your several videos, my eyes can not stop following your sketching and writing. 1 The Sheekey Science Show Katie Scarlett Katie Scarlett 9 months ago (edited) Great review! Who was the scientist that came up with the Free Radical Theory of Aging? Each copy of the cell that is made after the Free Radical Damage has been done, is like a bad xerox copy till the original is very different from the copy. Inflammation is the same premise. Then the activation of the SIRT 1 Gene has been something that has been discussed in the past as well. Mitochondrial has not been addressed by anyone except physicians active in Chronic Fatigue Syndrome. So that would be interesting. Emmanuel Trejo Emmanuel Trejo 1 year ago Excellent, thank you very much 1 The Sheekey Science Show Aetheral Passenger Aetheral Passenger 5 months ago Omg thank you for this again. I didnt have the time to read all of it. Subbed! The Path of Eudaimonia The Path of Eudaimonia 6 months ago Searching for "Lifespan summaries" got me here, and I am so happy for finding your channel! The Sheekey Science Show Pickaxing on Europa ! Pickaxing on Europa ! 3 months ago These book reviews keep getting better and better. 🐳 Zombie Prodigy Zombie Prodigy 1 year ago (edited) I have a question! :) He claims that we need to put our body into "stress modes", to activate our sirtuins, and that by doing so, they will help repair damage caused by "epigenetic noise." The thing Im not understanding is that he says sirtuins going back in the wrong spots sometimes and slicing genes not meant to be sliced, is what causes aging. So why on Earth would we ever want to send out more sirtuins??? Maybe I'm confused here, but why is moderation good? I know it is, but why is almost all activity not harmful?? Say even weight lifting, where you tear your muscles to build new ones. He says that fine, but why?? Would that not causes sirtuins to repair and then maybe go back into the wrong places??? Thanks so much for helping! :) 1 Yavuz Bahadır Taktak Yavuz Bahadır Taktak 7 months ago nice and precise. here is a thing: if scientists manage to achieve prolongation of life and if it will be accessible to anyone, human population will exponentially grow (do we have enough energy to keep growing and keep nature clean :P); if it stays as a privilege in rich guys' hands as Harari mentioned we are creating superhuman beings. Maicon Moraes Maicon Moraes 1 year ago NICE! I'm surely going to buy it 1 The Sheekey Science Show Chewing The Fat Chewing The Fat 1 year ago For the resveratrol side, the issue is with bio availability. And wine and absorbing through the lining of the mouth is the most bio available process. And while true as to the amount of wine required to be effective, dr Phil Norrie has developed “the wine doctor” wine and resalixer. So in the case of the resilixer, you take 50ml and rinse around your mouth for a few min and it’s the equivalent resveratrol to 10 bottles of red wine. While the bottle of wine doctor wine contains the equivalent resveratrol to 20bottles of red wine. Feel free to contact for more info Christopher Ellis Christopher Ellis 1 year ago (edited) I'm reading the Romanian edition. (The editor cannot decide whether it's Sydney or " Sidney. The Spaniards are similar confused" The FDA is an American problem. Kira Senna Kira Senna 1 year ago is a hot shower also considered a thermoneutral zone? i would prefer this over a cold shower though J z J z 2 years ago Thanks! 1 The Sheekey Science Show walterjab walterjab 2 years ago Nice, thank you. 1 The Sheekey Science Show Gio Gio 2 years ago Nice video and work 1 The Sheekey Science Show Buzz231094 Buzz231094 1 year ago This was interesting The Sheekey Science Show Ahmet Dizioglu Ahmet Dizioglu 2 years ago Thanks 1 The Sheekey Science Show shivam vaidya shivam vaidya 2 years ago Audio is very bad 2 Ed Mylett 634K subscribers Most of us want to live as long as possible. It’s a SURVIVAL INSTINCT that’s hard-wired into our DNA. BUT IT’S NOT ENOUGH TO LIVE A LONG LIFE. OUR QUALITY OF LIFE MATTERS, TOO. Unlocking the secrets to a long, healthy life has CHALLENGED MANKIND since the dawn of medical science. Those of you who know me, also know I’ve been fascinated by this subject for quite a while, too. That’s why it’s a great privilege to welcome back this week’s guest, DR. DAVID SINCLAIR. He is a LEADING SCHOLAR and Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at HARVARD MEDICAL SCHOOL where he has been teaching aging biology and translational medicine for aging for the past 16 years. More than that, he is also a foremost researcher best known for his work on UNDERSTANDING WHY WE AGE and HOW TO SLOW ITS EFFECTS. Contemporary BLEEDING EDGE RESEARCH and scientific advancements have propelled us forward and not only UNLOCKED SECRETS TO LONGEVITY but have also created new questions and curiosities that continue to excite our BEST AND BRIGHTEST MINDS. And few people on planet earth are as well versed or as educated on this subject as Dr. Sinclair. He lives in a world filled with deep examinations of hormesis, sirtuins, energy metabolism, biosynthesis, mTOR levels, reprogramming genes, mitochondria, learning and memory, time-restricted feeding and caloric restrictions, neurodegeneration, and cancer. While many of you may AWESTRUCK by this area of science, you should also be EXCITED by Dr. Sinclair’s research, because one day it will have a DIRECT IMPACT on you. This week, we’re going to translate what that research means to you in practical terms…and it’s coming sooner than you think! Dr. Sinclair covers a wide range of topics from red light therapy, to the effects of glucose on our bodies, hormone replacement, and the importance of being physically active, fasting, and not eating meat. We also touch on ALTERING DNA which holds the possibility of significantly extending life, and CURING HORRIFIC DISEASES like cancer, MS, Alzheimer’s, Parkinsons, and many others. Our discussion isn’t just about theories and research though. Dr. Sinclair has also got some HANDS-ON TIPS on what you can do to start to start feeling and looking younger right now. So, sit back, relax, and LEARN. CLASS IS ABOUT TO BEGIN, and I guarantee, you won’t want to miss it. 0:00 Intro 1:25 Are we actually younger if we look younger? 2:23 The basis of hormesis 5:01 Effects of time-restricted feeding 8:34 What are mTOR levels? 11:01 David's thoughts on physically active people fasting & not eating meat 15:59 Effects of glucose in our body 21:29 David's thoughts on red light therapy 25:06 How is age measured today? 29:39 David's thoughts on hormone replacement 36:04 Low levels of growth hormone make you live longer 38:58 David's thoughts on NAD 42:21 How Metformin affects glucose in our body 46:13 What is MOTS-c? 47:58 Where are we today in terms of being able to alter DNA? 52:02 What's David most excited about his work right now? 1:38:00 Is there a negative to people living so much longer? 1:02:58 Is there anything that worries David? 1:04:26 Other things that can extend or better your quality of life #DavidSinclair #reverseaging #antiaging #antiagingtips #antiagingfoods #antiagingtreatment #hormonereplacementtherapy #redlighttherapybenefits ---- Thank you for watching this video—Please Share it and get the word out! What part of this video resonated with you the most? Comment below! 👇 SUBSCRIBE TO ED'S YOUTUBE CHANNEL NOW 👇 https://www.youtube.com/channel/UCIpr... ---- Let's MAXOUT! Send me a text message at 714-916-9144 to receive weekly updates when new episodes are available! ---- → → → CONNECT WITH ED MYLETT ON SOCIAL MEDIA: ← ← ← → → → CONNECT WITH ED MYLETT ON SOCIAL MEDIA: ← ← ← ▶︎ YOUTUBE | https://www.youtube.com/edmylett ▶︎ INSTAGRAM | https://www.instagram.com/edmylett ▶︎ FACEBOOK | https://www.facebook.com/EdMylettFanPage ▶︎ LINKEDIN | https://www.linkedin.com/Edmylett ▶︎ TWITTER | https://www.twitter.com/edmylett ▶︎ WEBSITE | https://www.EdMylett.com ---- #EdMylett #Motivation Chapters 501 Comments rongmaw lin Add a comment... Steve S Steve S 5 months ago Aging is a profoundly negative process. This interview causes optimism to soar! Dr Sinclair: please hurry, I'm older than you but trying just as hard to stay youthful. Intelligent interview. 42 Diane Hansen Diane Hansen 4 months ago Ed is a great host!! He is humble, intelligent, and asks important questions. David Sinclair is the man! He's so knowledgeable, humble, and clear. Thank you both for a first rate podcast!! 33 Richard Lock Richard Lock 5 months ago I’ve been following David Sinclair for a while and doing intermittent fasting for the last 9 months because of his advice. I’ve never felt consistently healthier! Cheers for putting this together, Ed! 129 The Ancients Ancients The Ancients Ancients 4 months ago I'm surprised at how Sinclair who was written off over a decade ago has some revival again by people newly interested in this subject ! Most serious experienced cellular aging experts dismiss him with his vague science 7 Mary Fitzgerald Mary Fitzgerald 4 months ago This is the best interview I have heard to date about anti-aging, age reversal techniques currently available and what to expect in the future. I had to share it with my friends. 4 Evan Carmichael Evan Carmichael 5 months ago What an episode. Ed + David is pure fire!! :) #Believe 30 The Calming Gourmet The Calming Gourmet 4 months ago Re: diet, something interesting with 23&me, you can download your genetic weaknesses and put it in a program to learn, among other things, what foods to focus on with relation to your genetic weaknesses. Approx. 80% were animal-based food suggestions, not plant based. Find out what's right for you and create your own wellness journey. Certainly learn from others, but each of us are different, including Dr. Sinclair. 🌼 4 Jessica Terry Schneider Jessica Terry Schneider 4 months ago Incredible!! So grateful to have people like you Sinclair for diving into this industry and Ed for the platform and using it to share some amazing content. 👏 11 Monica Brante Monica Brante 4 months ago (edited) This is SO good! Thank you for sharing. - It is a lot and I need to listen to this a few times, but I feel that it is all here, which is great! Love it when he comments on how woman also benefits... there is very little research done on the female body, fasting etc. 5 J E J E 5 months ago This episode was suggested to me by a friend, great interview questions and an amazing episode. You have a life long listener now. Thanks for the actually useful content 10 Shuli Bitton שולי ביטון Shuli Bitton שולי ביטון 5 months ago I'm so looking forward to this interview! I still remember the previous one which was super fantastic and I learned so much new information I had never heard of! He definitely looks younger since the last interview which reminds me of the movie Benjamin Button. We want the body not to become complacent, to put the body in perceived adversity as opposed to an abundance state.I agree that preventative medicine is so much better than treating symptoms after you get ill.I've been doing time restricted eating for many years now. I eat two meals a day without snacking and never eat breakfast. Moderation is the key to everything in life. I can't wait for my daily walk to listen to this entire episode #MAXOUT from Israel 32 Peter Horak Peter Horak 5 months ago I’m blown away by the information that David has shared about the latest status of anti-aging science. Absolutely incredible what has already been achieved. I had no idea we are so close to some incredible medical treatments that could literally reverse our aging clock ! Great interview Ed 🙏👊 34 Lessons in 30s Lessons in 30s 5 months ago For the 1% of people reading this, I hope you become successful in your life! 33 LittleOne3179 LittleOne3179 5 months ago (edited) I’m curious as to when inside tracker will include estrogen and other female hormones in their bio markers. I am 59 years old and a powerlifter, my inner age scored 9yrs younger than my biological age. My testosterone levels were even optimal, however the SHBG levels are an issue and I am sure not allowing me to optimize the testosterone I have. I sincerely hope more female hormones will be included someday? What can we do naturally to increase estrogen levels ? I’m currently investigating this and would love your thoughts. Menopause isn’t healthy for any woman and affects aging. Thank you for all you do! 9 benjiebarker benjiebarker 5 months ago Dr Sinclair’s resveratol and NMN regimen is helping my mom’s alzheimers…i think reversing aging is helping her Alzheimer’s 7 Life is wonderful Bao Life is wonderful Bao 5 months ago 13) metformirn therapy can help you 14) nmn therapy protecte against aging 15) Mot C 16) crispers (changing gene) while fixing genes 18 Sonya Sun Heart Sonya Sun Heart 4 months ago (edited) It's happening!! When i gave birth to my daughter at 41 , my biological age was 27 years old ! I love learning about this topic; thank you so much for this talk - I'm 48 yrs young and never felt better ! 😁🙏 13 JULES22 JULES22 4 months ago My great great aunt is 105 yrs ,,, still bakes and walks everyday, takes no medication, takes ensure for past 30 yrs, had her memory and no health problems,,,,, eats what she wants,,, no alcohol, no cigarettes, no drugs,,, big family,,,,, believes in god 2 Grant Burris Grant Burris 3 months ago Well done! I follow all David Sinclair's talks. I am grateful for the work he does and his willingness to explain it. I greatly enjoyed the host and how he managed the questions. Great! 1 Richard Sheridan Richard Sheridan 1 month ago (edited) Ed and David, I literally stumbled on this interview at 1am in the morning. I've been slowly learning about the various components to combat aging from Dr. Sinclair and it's been daunting. This interview is the single most information power packed episode I have ever seen in almost two years of watching/listening. This is as close to a true personal road map as I have ever had and I am Dr. Sinclair's age. My dream is to be able to care for my aging parents in their 80's and like Ed, I too have chills going up my spine with excitement about what is in the near term future. What research has done and simple things that we people can do, simple choices we can make to extend both lifespan and healthspan. Thank you so much for this interview, I am hopeful, inspired and excited. 1 Yawa huang Yawa huang 4 months ago I really like dr David podcast ! My parents and my only sister are all have high blood pressure. I am only one don’t it☺️ I am 56 years old woman and I have 0 chronic disease- I have been always eating whole foods, always listen to my body ❣️ 1 Get it as soon as Monday, Aug 1 FREE Shipping on orders over $25 shipped by Amazon