Horvath on epigenetic aging the DNA PhenoAge and GrimAge clocks 101,149 viewsDec 22, 2020

Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks 101,149 viewsDec 22, 2020 FoundMyFitness 426K subscribers Steve Horvath, PhD, ScD is a professor of human genetics and biostatistics at UCLA's Fielding School of Public Health. Dr. Horvath is the creator of the Horvath Epigenetic Aging Clock. His work incorporates elements of biostatistics, genetics, epidemiology, epigenomics, and other fields of study. He applies his understanding of this diverse range of disciplines to study a spectrum of chronic diseases, including cancer, cardiovascular disease, neurodegenerative disease, and other diseases of aging. Dr. Horvath's so-called "pan-tissue epigenetic aging clock" is an algorithm that accurately predicts a person's chronological age from marks on the DNA across multiple cells, tissues, and organs, and even mammalian species. Further refining this initial algorithm, Dr. Horvath built on this to develop second-generation clock algorithm that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan. One of these clocks, the GrimAge clock, is named deliberately after its connotation: predicting time until death ("Grim"). In this episode, Dr. Steven Horvath describes epigenetic clocks and their role in predicting – and possibly slowing – aging GET THE SHOW NOTES: https://www.foundmyfitness.com/episod... (👆↑ You'll really want these. These notes have clips, in-depth timeline, quotes, a glossary, a transcript, and more.) Dr. Horvath's faculty bio page: https://ph.ucla.edu/faculty/horvath Dr. Horvath's Wikipedia page: https://en.wikipedia.org/wiki/Steve_H... Dr. Rhonda Patrick's 3-minute video crash course in epigenetics: https://www.foundmyfitness.com/episod... The FoundMyFitness OVERVIEW ARTICLE on epigenetic clocks: https://www.foundmyfitness.com/topics... (👆↑ This article has dozens of citations!) CHAPTERS 00:00:00 - Introductions 00:00:34 - Horvath Aging Clock 00:01:50 - Explaining the error rate 00:06:42 - Hereditary + lifestyle factors 00:15:03 - DNAm PhenoAge vs GrimAge 00:22:50 - Telomere science shortcomings 00:26:08 - Prolonging the epigenetic clock 00:50:56 - Epigenetics: Cause or consequence of aging? 00:56:53 - Vitamin D reverses epigenetic age 00:59:20 - Omega-3 slows down the GrimAge clock 01:04:27 - Ongoing research ⏳ #aging #longevity #epigenetics 🧬 Chapters Introductions 0:00 Horvath Aging Clock 0:34 Explaining the error rate 1:50 Hereditary + lifestyle factors 6:42 DNAm PhenoAge vs GrimAge 15:03 Telomere science shortcomings 22:50 Featured playlist 51 videos Interviews FoundMyFitness 317 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 1 year ago (edited) 00:00:34 - The Horvath clock explained: Methylation patterns at unique areas of our DNA involved in gene regulation predict a person's age within four to five years. 00:06:42 - The effect of HEREDITY on the epigenetic clock rate (determines as much as 40 percent of rate). 00:12:48 - How the stability of epigenetic information has potential implications in forensic science. 00:26:08 - How diet, exercise, education, and lifestyle factors effect the epigenetic clock. 00:31:59 - How transplanting young cells into an old body may slow epigenetic aging of the recipient. 00:47:23 - Reprogramming pluripotent stem cells by activating specific genes can reset the epigenetic clock. 00:50:56 - Do epigenetic changes drive aging, or are they the result of aging (just the "face of the clock")? 01:02:32 - How poor sleep speeds up the epigenetic clock. 01:12:12 - Super silly outro easter egg This episode has a lot of amazing studies and figures included in the slides, which are available to FoundMyFitness Premium Members, in a convenient presentation! To find out more about becoming a Premium Member, visit: https://www.foundmyfitness.com/premium (Premium membership helps us make more videos and is a great experience for members! 👆❤️) 59 Joe Amrine Joe Amrine 1 year ago Definitely one of the most entertaining hours of 2020... awesome idea showing citations for clinicians and researchers who are interested in learning more about these topics! 43 FoundMyFitness Live Forever or Die Trying Live Forever or Die Trying 1 year ago Steve is a legend. Thank you for having him on! 49 FoundMyFitness Dr. Samiera Sadoon Alhassani Dr. Samiera Sadoon Alhassani 11 months ago Thank you both for sharing such level of interesting information which usually kept in the labs..Thank you and may God bless you in your biological age of longevity and wellness. 2 tinox12 tinox12 1 year ago thank you so much Rhonda, without people like you we wouldnt bring important topics like aging to the general public. for some reason the average guy doesnt care about aging, only later in life when its already too late. its truly one of the most important topics in the modern times tho 4 J M J M 1 year ago Your energy and passion gives me the biggest grin possible. I just can’t describe how much appreciation I have for you, your work and the people you interview’s work. On a side note - do you have any books you recommend for someone trying to eat a diet for longevity and health? Thanks Rhonda, hope you’re doing well! 6 Peter Peter 1 year ago (edited) Thanks. @32 on parabiosis - recently, the Conboy lab performed a variation (not really parabiosis though) in which 50% of plasma in older mice was replaced with saline and albumin. They saw tissue regeneration in 3 tissues, the liver, muscle, and hippocampus. Lots of changes in many plasma proteins. Would be interesting to know how long this effect persists and if epigenome is affected. 9 ET ET 1 year ago Awesome content! Thank you SO much for your devotion to this field, much much appreciated. 2 J T J T 1 year ago (edited) I love the way you add the literature excerpts during the interview. It adds new dimensions to the presentation & gives me new rabbit holes to run toward & through. 6 Vetruvio Vetruvio 1 year ago Extremely interesting and fascinating. Thank you very much for this interview! 4 Kubs Kubs 1 year ago Great interview. We definitely need a follow up with Dr. Horvath in a year or two. It's clear this field is moving _fast_! At 00:27:39, if I'm reading this correctly, it appears that carotenoid consumption has a much greater impact on GrimAge than fruits & vegetables or exercise. Also, reducing C-reactive protein seems to have a profound effect as well. Traditional health advice is focused on diet & exercise, but would it have a bigger impact to increase carotenoid consumption and reduce CRP (through L-Carnitine or curcumin)? 2 Julia Hello Julia Hello 1 year ago Dietary polyphenols play a key role in modulating these modifications thereby delaying aging and extending longevity. In this review, we summarize recent advancements linking epigenetics, polyphenols and aging as well as critical findings related to the various dietary polyphenols in different fruits and vegetables. BFBF Rob BFBF Rob 1 year ago If at 16 years old you stored some of your own bone marrow. Could you in fact store it for long periods of time 10-50 years and then inject your own bone marrow 10-50 years later, would it age while stored? Would it eliminate graph vs host issues if it was your own bone marrow? Just curious. 47 FoundMyFitness David A David A 1 year ago A great interview and guest. I watched it while pedaling on a stationary bicycle. Rhonda is simply a nice human being 😊 11 Quest Love Quest Love 1 year ago This podcasts follows such a natural but still hardcore biology involved flow, I love it. 1 2coryman 2coryman 1 year ago (edited) Thanks for the great info, I suspect that since there is so much to this science that we cannot oversee or micromanage, the best that we can do is to give our bodies the best food to take care of itself, it is divinely programmed to do a much better job at staying young than we can ever hope to do by meddling in its work, All we can do is to understand our organism and not abuse it and give it what needs to repair itself and stay young, cheers 2 English Bob English Bob 1 year ago I don’t really understand when Steve says that a healthy life style doesn’t affect the epigenetic ageing, if that was the case what on earth is David Sinclair doing . I am a tad confused 18 Practical Health Practical Health 6 months ago Great, insightful discussion, thank you, Rhonda! Bhupen Huidrom Bhupen Huidrom 1 year ago Greatly appreciated for bringing such research studies to the public domain 👍👍👍👍👍!!! 6 HSCHSC211 HSCHSC211 1 year ago Vielen Dank Steve für deine herausragende Arbeit, welche den Durchbruch brachte! 🙏🏻☀️ Access Access 1 year ago Hi Rhonda I've been a long time fan of yours and I'd love to see you talk about human growth hormone and its connections to aging then dive into how we can take action to have proper/optimal levels of HGH! Keny Charles Keny Charles 1 year ago (edited) I am discovering many instances of people who sleep 5 hours or so , lately. Thank you for this presentation. Great interview! 1 S o F Daniel S o F Daniel 1 year ago Really appreciate the effort you put in to put infographics on as well! Jarod King Jarod King 1 year ago I would love to see a cross-sectional correlation between GrimAge and lifestyle factors for low-carb and fasting cohorts. I am assuming his data was from nHANES or some other SAD-based cohort. Stevo Stevo 5 months ago this was so interesting, but also rather depressing. So my take from this is that we almost have a predetermined lifespan and there is seemingly little we can do about it. Diet and exercise he claimed has minimal effect on increasing our lifespan. So if we have a father who died at 64 from heart attack and a mother who lived to age 90, it would appear we can only keep our fingers crossed that we inherited our mothers epigenetic age markers? 1 gary gjl gary gjl 7 months ago I listen to Dr. Patrick frequently and a few other PhDs. I will now follow Dr. Horvath.I donot understand why medical doctors are looking after my health matters when these individuals are the ones that know what they are talking about. Michael Workman Michael Workman 10 months ago The U-shaped effect appears to apply to stress as well. Too much or too little stress isn’t good either. Fasting produces stress that activates autophagy. ishtar0077 ishtar0077 6 months ago (edited) The information in this video amazes me. I had to rewatch it twice 💜 Julia Hello Julia Hello 1 year ago An integrative metabolo-epigenetic outlook supports a new model whereby metformin operates as a guardian of cell identity, capable of retarding cellular aging by preventing the loss of the information-theoretic nature of the epigenome. The ultimate anti-aging mechanism of metformin might involve the global preservation of the epigenome architecture, thereby ensuring cell fate commitment and phenotypic outcomes despite the challenging effects of aging noise. Metformin might therefore inspire the development of new gerotherapeutics capable of preserving the epigenome architecture for cell identity. 1 Dr Gayle Delaney Dr Gayle Delaney 1 year ago (edited) Thank you, Rhonda, for your added explanatory and elaborative notes. They are a great help to me. But! I can't understand the charts for Young Finns study nor the Vitality 90+study! (@9:38) The text on on the right gives us the gist, but how do the charts show the aging rates over time? shouldn't any one dot either be two as seen at different times, or does each dot show that there is no movement in rate? Is each stationary over time? What am I missing? If there is NO difference in rate and each dot is stationary over time, then all I see in the charts is the distribution of some unknown number of different subjects who live at a slower or faster DNAm aging. Julia Hello Julia Hello 1 year ago We evaluated the impact of a 1-year Mediterranean-like diet in a pilot study including 120 elderly healthy subjects from the NU-AGE study (60 Italians, 60 Poles) by measuring the changes in their epigenetic age, assessed by Horvath's clock. We observed a trend towards epigenetic rejuvenation of participants after nutritional intervention. Matthew Andre Mink Matthew Andre Mink 1 year ago Great interview -- from the beginning to the end!!! However, I realy wonder what the these two doctors think about the current, and soon be be a common, mRNA "vaccines"/drug delivery system/s and their potential effects on human epigenetics? 2 Melissa Costin Melissa Costin 1 year ago I think cannabinoids are better antioxidants than fish oil .,Aust health minister just called for ideas to grow industry, so I sent him this video and suggested he look at cannabinoids and molecular aging ..the u telomere shape and aging was a learning curve for me as I was thinking of it re skin photoaging analysis..brilliant cutting edge conversation, much appreciated..looking forward to learning more basia jamróz basia jamróz 1 year ago (edited) I had low growth hormon level as a kid. I've even had bone growth checked and my bones marurity were 1.5 lower (younger) then calendar age. End up short but still at lower end of normal hight (5'2). Same for rest of my family. I've always looked younger, smaller and this continue till this day. I am 33 and I am often thought that i look much younger. I wonder is this related to low growth hormone level. 1 pitapep pitapep 1 year ago Probably my live-style interventions will not prolong so much my health span but I'm feeling so well that I would continue doing them: 1 or 2 hours exercise outside during sunrise, semi-naked, after 16 hours fasting, CT and two meals a day high-fat low carb. 5 Red Pill Lense Red Pill Lense 11 months ago My IQ increased because of this great interview 🤓 Margics Margics 4 months ago (edited) Good points. To the sentence “ Double the exercise” is not always good haha it all depends the level of exercise the person is doing and if it fits their requirements. Because exercise is personal. Not one size fits all. Personal trainers are the adequate professionals in charge of prescribing it. Unfortunately everyone talks about exercise incorrectly and ignoring the methods for exercise prescription to produce excellent effects on health and aging. Alpha Health Alpha Health 1 year ago Hey Rhonda, do you know what the test-retest variability is for the original pan tissue clock? G.V. Bangkok G.V. Bangkok 1 year ago Not commented upon, but after smoking, a high CRP in the long list of measurements, and lifestyle data, seems to be a rather important factor. Reversely, I reckon having a very low CRP, is a good thing to have, as I do (statins + ace inhibitors + omega 3), and I am happy about it. Fact Checker Fact Checker 1 year ago Another issue is the long list of deficiencies that add up with age and largely go unmeasured in the population. Vitamin D is about the only one of dozens that actually gets measured and studied much. Are we just measuring the combined effects if 20 or so deficiencies in one clock and methylation process? 1 Rui-9-CS Rui-9-CS 1 year ago what a legend! 4 Fourthz 44 Fourthz 44 1 year ago Watched the entire video. This was super interesting even though im not a scientist (: 1 Hanz Lammersdorf Hanz Lammersdorf 1 year ago Fantastic interview! D D 1 year ago Rhonda, would you know of any information pertaining to if graying early is correlated with higher or lower epigenetic clock? 5 Daily Dose of Medicine Daily Dose of Medicine 1 year ago Good explanation 👍 3 Bakhtiyar Neyman Bakhtiyar Neyman 1 year ago Thanks Rhonda, another great interview! 1 Kubs Kubs 1 year ago 😂😂 I was not expecting that sudden promotion at the end. I was completely caught off guard and laughed my ass off. 😂😂 3 Siddarth Siddarth 1 year ago Was really looking forward to this so thank you 🤗 3 Sleep Smart Smash Stress Sleep Smart Smash Stress 1 year ago Thanks a lot Dr. Steve Horvath for introduction to Happy Genetic aging to predict healthspan. I wonder that if the lifespan of a living object is measures using a clock they are either worms and fruit flies or extremely ultrashort lived primates. We tend to measure lives of even infants on a calendar. How about using a century calendar to measure human longevity? 1 fuzzel fuzzel 1 year ago 1:08:00 Vitamin-D3 reduces methylation speed. Virus infection seems to increase it. Radiation doesn't affect it. That makes sense to me, if temporary methylation is a defense mechanism targeted at viral DNA. By methylating the viral DNA and the cellular core DNA the virus could be prevented from replicating itself. But you cannot 100% undo this process post-infection, because that would hurt cell specialization (anyone who has ever built a PID controller, knows why). Radiation damage, on the other hand, happens absolutely randomly when a highly energetic particle rips through your tissue. There is no way to prepare for it. c c 1 year ago Off topic: what are your thoughts on using powder versions of green vegetables in smoothies 4 The Sheekey Science Show The Sheekey Science Show 1 year ago Ah this is so cool, thanks for the interview!! :) 18 Andi de Mattos Andi de Mattos 5 months ago Great to see you again Steve. You were my boyfriend's roomate (Rick de Mattos) at UNC CHAPEL HILL over 30 yrs ago! YOU have not AGED MUCH AT ALL YOURSELF! Great interview. Andi Sloan de Mattos. Rick enjoyed seeing you in this video! FoundMyFitness Clips FoundMyFitness Clips 1 year ago (edited) those member benefits... they're spicy! 01:12:12 😊 Like and subscribe with notifications on for a ton of great episodes AND FoundMyFitness coming out in the new year. Thank you for watching! 2 Danny P Danny P 1 year ago I would like to think that lifestyle intervention plays a much more significant role in life span then Dr. Horvath believes. Firstly, it’s ambiguous at best. Because for me I take 2000mg of resveratrol every day, don’t smoke, lift weights, take plenty of vitamins. But maybe someone else simply eats the Mediterranean diet. It can mean so much but varied boredom to person is my point. Do we really know the perfect lifestyle to live to increase lifespan? Probably not! Once we do know, it should play a significant role. Bahar Zaap Bahar Zaap 1 year ago This was way too short . Can we invite him once a month and delve into deeper areas you touched upon please ? 25 Lucrezia Dippolito Lucrezia Dippolito 1 year ago Speaking of age, why is there an old rotary phone sitting on the desk ? Other than that, very advanced ground breaking information. Fascinating!!! Sergey Sergey 1 year ago Very interesting. Thanks! Maistora11 Maistora11 1 year ago (edited) I wonder if there might be some kind of a connection between the suggested vitamin D supplementation effects on the clock (57:32) and the benefits of vitamin D related to the coronavirus, age being a major factor there. 1 Earwaxfire909 Earwaxfire909 1 year ago Does Histone acetylation contribute to aging? Is that a synergistic factor? LifeMe Vzw LifeMe Vzw 1 year ago the Horvath clock can hardly be changed by lifestyle interventions?... and yet there is overwhelming evidence that a healthy lifestyle makes people living longer (and healthier). is this not contradictory? 7 premier69 premier69 1 year ago I've been on a ketogenic diet study binge as of late and i wound up here :) 1 Quest Love Quest Love 1 year ago Wonderful podcast john diogenes john diogenes 1 year ago Thanks so much for being you Rhonda, I'm hoping you will comment soon on the epigenetic reset of a mouse eye 1 SB SB 9 months ago Very interesting stuff... but a lot of contradiction too. Lifestyle doesn't make much difference...except it might in specific tissues being an example. Will be watching this field with great interest. I would guess many people wouldn't want to get these tests out of fear. Julia Hello Julia Hello 1 year ago Resveratrol increases the lifespan of several model organisms by regulating oxidative stress, energy metabolism, nutrient sensing, and epigenetics, primarily by activating sirtuin 1. Bluecloud909 Bluecloud909 1 year ago Fantastic video. I'm just wondering what supplements Dr Horvath is taking? 1 Laymen's Growing Laymen's Growing 1 year ago Do you by chance know any good experiments I can do with my diet for educational purposes? I want to put in on my new channel on a health segment. Ive done keto and vegan with great results. Dont mind any diet as long as its not too unhealthy for the before. kevinsbott kevinsbott 1 year ago This is totally amazing! 3 GutBubble GutBubble 1 year ago Can this test be conducted by a doctors office or a reputable online service? I saw several online but nothing endorsed by Dr Horvath, Avarua59 Avarua59 1 year ago Are those variants shown at 27:39 ranked from strongest to weakest? Marc 300 Marc 300 1 year ago When will the Horvath clock test be available for purchase? And where? 1 I C I C 1 year ago The geek in me thanks you! 🤓🙏💞 6 Cereal_Qilla Cereal_Qilla 1 year ago Rhonda! Can you do a video on aging and hair? What foods to eat to support hair as you age etc? Love you bye 2 Abio Genesis Abio Genesis 1 year ago (edited) I really appreciate it Rhonda, Looking forward to a new interview with David Sinclair 2 Fact Checker Fact Checker 1 year ago I love the interview format with the key researchers instead of another flat presentation that spends too much time on the introduction. Nate Staab Nate Staab 1 year ago You really have to wonder who dislike Dr Patrick’s videos. 14 I accept all cookies I accept all cookies 1 year ago Sounds like we're on the cusp of something really big, wrt to the epigenetics of different cell types. 4 Quest Love Quest Love 1 year ago @40:50 great point indeed Rhonda, proud of you Rafah Alsahlani Rafah Alsahlani 1 year ago Th best I am watching it a few more times sooooo awesome 1 Yavuz Bahadır Taktak Yavuz Bahadır Taktak 7 months ago what a delicious conversation! Antonio S Antonio S 1 year ago I’d buy your book on Amazon before my girlfriend’s! Where’s it at! This is deep! AmyNicole321 AmyNicole321 1 year ago Hi Dr. Rhonda. Any update on the CHORI-Bar? The last article I read said it was going to be available summer 2019, but I cannot find anything else out about it. Chengue01 Chengue01 1 year ago What is the defin