Rhonda: on: Dr. David Sinclair on Informational Theory of Aging, view: Nov 6, 2019

#aging #longevity #fasting Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More 579,087 viewsNov 6, 2019 FoundMyFitness 425K subscribers ⏳ David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor. Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer. Dr. Sinclair obtained his doctoral degree in molecular genetics at the University of New South Wales, Sydney, in 1995. Since then, he has been the recipient of more than 25 prestigious honors and awards and in 2014 was named as one of TIME Magazine’s 100 most influential people in the world. Dr. Sinclair recently authored the book, Lifespan: Why We Age – and Why We Don't Have To. https://www.simonandschuster.com/book... In this episode, Dr. David Sinclair discusses exciting new findings in the field of aging research, with special emphasis on the roles of sirtuins, resveratrol, and NAD+. - Learn more about sirtuins in this overview article https://www.foundmyfitness.com/topics... - Learn more about resveratrol in this overview article https://www.foundmyfitness.com/topics... - Learn more about various forms of fasting in this overview article https://www.foundmyfitness.com/topics... - Learn more about NAD+ in this overview article. https://www.foundmyfitness.com/topics... - Learn more about nicotinamide riboside in this overview article https://www.foundmyfitness.com/topics... - Learn more about nicotinamide mononucleotide in this overview article. https://www.foundmyfitness.com/topics... Chapters: 00:00:00 - Introduction 00:00:36 - Activating longevity genes 00:05:02 - Sirtuin activation 00:07:19 - Fasting, caloric restriction, and exercise 00:10:56 - NAD+ 00:16:00 - Resveratrol 00:20:00 - Epigenetics 00:36:22 - Boosting NAD+ 00:41:11 - Excess calories accelerates 00:44:26 - Resveratrol slows aging 00:51:00 - NR & NMN in aging 01:00:05 - Sleep improves glucose metabolism ⏳ #aging #longevity #fasting #epigenetics #NMN #NR 🧬 1,157 Comments rongmaw lin Add a comment... FoundMyFitness Clips Pinned by FoundMyFitness FoundMyFitness Clips 2 years ago (edited) 00:00:36 - Landmark moments in longevity research with the discovery of genes that control the aging process and how these genes can be activated by lifestyle factors such as fasting and exercise. 00:01:06 - Altering the insulin/IGF-1 signaling pathway in earthworms can extend their lifespan by 100%. 00:01:45 - Slowly ageing by design: the rise of NAD+ and sirtuin-activating compounds. 00:05:02 - How resveratrol may delay aging by activating a class of enzymes called sirtuins. 00:06:15 - How the addition of an extra copy of the SIR2 gene in S. cerevisiae (yeast) can extend yeast lifespan by 30%. 00:06:40 - How having high levels of sirtuins may give organisms the benefit of caloric restriction or other stressors such as heat stress or amino acid restriction without actually engaging in those activities. 00:07:50 - How fasting for one or two days per week, a type of intermittent fasting, may activate sirtuins sufficiently to recapitulate the benefits of long-term caloric restriction. Review on caloric restriction and sirtuin biology. 00:08:15 - How the metabolic switch into ketosis may be an important differentiator between ongoing caloric restriction and finite periodic fasts. 00:08:50 - How caloric restriction potently increases sirtuins, as measured by SIRT1 levels, by as much as 5- to 10-fold in the liver and muscle of rats, but this beneficial activity is immediately dampened by the introduction of IGF-1 and insulin. 00:10:13 - How several pathways, including those involving sirtuins, insulin/IGF-1, and mTOR, all interact as components of a highly conserved holistic network to create the benefits of caloric restriction. 00:10:56 - Caloric restriction, fasting, and exercise increase levels of NAD+, and this activates sirtuins. 00:12:20 - NAD+ may regulate circadian rhythm though its control of sirtuins, which in turn regulate both the circadian clock in the brain as well as peripheral clocks, such as the liver. 00:13:00 - In addition to activating sirtuins, NAD+ is essential for mitochondrial metabolism and function but it is also required for repairing damage to DNA by activating an enzyme called PARP. 00:13:30 - How organisms have developed nutrient-sensing genetic pathways such as sirtuins, AMPK, and mTOR in order to understand what is going on in the environment. 00:14:44 - Although NAD+ levels and sirtuin activities decrease with age, animal studies suggest that raising cellular NAD+ levels can trick the body into thinking it is younger. 00:16:00 - Resveratrol enhances the binding of sirtuins to NAD+ thus making sirtuins more easily activated for a longer period. 00:17:28 - How DNA damage consumes NAD+ through the activation of PARP, a major DNA repair protein, leaving less NAD+ available to activate sirtuins and distracting sirtuins from fulfilling their other roles. 00:20:00 - Dr. Sinclair's informational theory of aging posits that aging is due to a loss of cellular identity, a type of epigenetic signal noise, that has parallels in biology with the signal correction capabilities of the TCP/IP protocol. 00:20:33 - Steve Horvath's epigenetic aging clock, which measures DNA methylation groups, may play a role in widespread gene regulation, including sirtuin genes, and how NAD+ may participate in resetting the clock. 00:22:56 - How the epigenetic clock can predict your chronological age and how long you have to live. 00:23:47 - How epigenetic reprogramming in old mice can restore youthful gene activity patterns, reverse the DNA methylation aging clock, and restore the function and regenerative capacity of the aging retina. 00:24:51 - The signal that resets the epigenetic clock in mice involves Yamanaka factors -- a group of four transcription factors that can reprogram an adult cell to become a pluripotent stem cell that can form any cell type. 00:26:24 - How short term treatment with the Yamanaka factors can reverse cellular and physiological hallmarks of aging and prolong lifespan in mice with a premature aging phenotype. 00:27:45 - Dr. Sinclair's hope that we may eventually find a way to induce Yamanaka factors in a way that is more safe and applicable to humans than current genetic engineering and viral techniques used in animal research. 00:28:25 - How fasting, exercise, and other lifestyle factors may slow the rate of epigenetic aging but may not be sufficient to reverse it like some of the powerful Yamanka factors may be able to. 00:29:51 - How Dr. Sinclair's lab and others are trying to find safe ways to reset the epigenetic aging clock with Yamanaka factors without causing tumors and other safety issues. 00:32:46 - How Dr. Sinclair thinks Claude Shannon's theory on mathematical theory communication may also explain the aging process. 00:34:02 - Dr. Sinclair's take on who some of the top scientists to follow in the field of aging epigenetics are, which includes Drs. Juan Carlos Izpisua Belmonte, Steve Horvath, Manuel Serrano, Anne Brunet, Shelley Berger, and Jessica Tyler. 00:36:00 - How nobel-prize winning biologist John Gurdon put an adult cell nucleus from a tadpole into a frog's egg, producing a new tadpole, suggesting that the genome can be reset to a very early stage in an organism's lifespan. Review on nuclear reprogramming. 00:36:22 - How cellular NAD+ is made from a variety of precursors including tryptophan, nicotinic acid, nicotinamide riboside, nicotinamide mononucleotide, and nicotinamide. Nicotinamide riboside gets converted into nicotinamide mononucleotide, which is then converted to NAD+. 00:37:33 - How NAD+ is a large molecule that does not get taken up in animals as efficiently as the NAD+ boosters nicotinamide riboside and nicotinamide mononucleotide, the latter of which is transported by a recently discovered transporter. 00:38:18 - How NAMPT, an enzyme in yeast that is activated by exercise and calorie restriction, is key for NAD+ production and longevity benefits. 00:39:45 - Plants produce compounds that activate sirtuin pathways in plants in response to stress and, in turn, the compounds activate beneficial pathways like the sirtuin pathway in humans, a phenomenon called xenohormesis. Resveratrol is one such compound and is produced when grape plants are stressed either in response to fungus or a lack of water. 00:41:11 - How small stressors such as exercise, calorie restriction, and ingestion of plant polyphenol compounds activate various stress response pathways in the body that help slow aging, but calorie excess and a sedentary lifestyle have the opposite effect, signaling the body to reproduce and continue aging, a concept known as the disposable soma theory of aging. 00:41:56 - When rhesus monkeys were fed a diet high in refined sugar (sucrose) and fat for two years, they experienced a 40% increase in arterial stiffness and inflammation but this was completely reversed if they were given 80 mg of resveratrol per day for one year then 480 mg/day for a second year. 00:44:26 - How resveratrol is a very insoluble molecule but its bioavailability can be increased if it is taken with food that contains a moderate amount of fat. 00:45:38 - Mice that were fed an obesogenic diet but were also given a low dose of resveratrol lived longer and had organs that were healthier and younger looking compared to mice fed the obesogenic diet alone. 00:48:32 - How a phase 2 clinical trial involving people with Alzheimer's disease showed resveratrol improved mental examination status scores, induced marker changes that might suggest reduced accumulation of amyloid-beta in the brain, lowered markers of activated microglia, and more. 00:49:28 - How resveratrol has been shown to induce autophagy by directly inhibiting mTOR through ATP competition in mice. 00:51:00 - How both nicotinamide riboside and nicotinamide mononucleotide have been shown to improve cognitive function and brain pathology in mice that have been engineered to get a disease similar to Alzheimer's disease. 0:51:29 - How treating mice with nicotinamide mononucleotide can prevent age-related endurance losses by promoting new blood vessel growth. 00:52:30 - How an NAD+ isotope tracer study revealed that orally administered precursors of NAD+ such as nicotinamide riboside and nicotinamide mononucleotide do not form NAD+ in any other tissues other than the liver, but that dose was half the amount used in animal studies that showed benefits in the brain and muscle. 00:53:37 - How there may be a threshold dose of nicotinamide riboside and nicotinamide mononucleotide that needs to be crossed in order to override the liver's first pass clearance mechanisms so that nicotinamide riboside and nicotinamide mononucleotide NAD+ levels rise in other tissues like skeletal muscle, and this is why almost all animal studies use very high doses. 00:54:13 - How there may be challenges in translating animal studies on nicotinamide riboside and nicotinamide mononucleotide to humans particularly due to the need to determine the dose required to promote health benefits. 00:56:33 - How a couple of clinical trials are underway to test safety with a molecule called MIB-626, which is a potential strong NAD+ booster. 00:59:16 - Older mice that were given NMN (300 mg/kg/day) experienced delayed aging in the liver, muscle, immune cells, eyes, and bones, but those that took a lower dose of NMN (100mg/kg/day or human equivalent of 8mg/kg/day) had improved mitochondrial function and enhanced physical performance. 01:00:05 - How fragmented sleep consistently leads to higher fasting and postprandial blood glucose levels. 522 KenDBerryMD KenDBerryMD 2 years ago Excellent info from 2 of my fav researchers! Take notes everyone 158 FoundMyFitness David Hanson David Hanson 2 years ago This the best David Sinclair interview that I have seen or heard. It really helps when the interviewer has so much knowledge on the subject. 526 FoundMyFitness Peter Peter 2 years ago Very well done! This discussion illustrates why its so helpful to have an interviewer (Patrick) who actually knows the subject matter well enough to keep it at level which is truly informative for reasonably well informed laypeople instead of the boringly simplistic repetitive level of so many others. 41 FoundMyFitness High Intensity Health High Intensity Health 2 years ago Pumped to check this one out! 81 FoundMyFitness Ron D Ron D 2 years ago Excellent; it gives someone with no background in biochemistry; a fair chance of grasping the concepts you're excited by Rhonda. Those notes on the screen and the time stamps; brilliant! I've heard David Sinclair several times now, but this was the most plausible presentation by far - now I want that book! Thanlyou 65 FoundMyFitness Aaron Esteban Aaron Esteban 1 year ago You and Dr. David Sinclair are AWESOME! I'm glad that I've found your channel Dr. Patrick! I love what you two are doing. I hope you two keep up the great work with your studies/research. I'd like to see more videos of you and Sinclair and showing the latest studies. 7 carpe diem jonah carpe diem jonah 2 years ago I shared your excitement as I watched this interview twice – back to back. As if I didn’t already have enough knowledge from your prior outstanding guest interviews. This interview ties together so many loose threads from your previous interviews into a more coherent and workable model of a longevity promoting lifestyle. Year by year, you are creating a magnificent narrative. Thank you for bringing the cutting edge of nutritional research into our living rooms. Long time supporter here. 31 FoundMyFitness Marcus Gitterle Marcus Gitterle 1 year ago Brilliant. Best aging science dialog I’ve ever heard! Bravo to David Sinclair for his work and for explaining it so lucidly, and bravo to Dr. Patrick for asking such great questions! 2 tubejuanso tubejuanso 1 month ago Probably the best technical interview that I have ever seen in my life. Sinclair is the master of his field, but Rhonda is so well informed and she handles everything in an excellent manner. She's awesome. Nova Aurata Nova Aurata 2 years ago Wow this was such an incredible interview! Thank you so much for doing this and yes please have David back on as soon as possible! :) 3 Tony's Place Tony's Place 2 years ago (edited) This was an awesome treat Rhonda! Thanks and keep up the amazing work!!! Eating in 10-hour window can override disease-causing genetic defects, nurture health was a study done at Salk that opened my eyes. Sirtuin enzymes and life span! Gypsy_Rebel_ Rose Gypsy_Rebel_ Rose 2 years ago My two favorite people on longevity. Almost hard to decipher the extreme genius. ♥️ 10 Keny Charles Keny Charles 2 years ago Thank you for this presentation. And you put timestamps in for different topics discussed ! You are so thoughtful. I will be coming back to this dialogue again and again. 14 FoundMyFitness Arianna Flores Arianna Flores 2 years ago I was so excited for this podcast and it was definitely worth the wait! Two amazing brilliant people, I'm excited for your next podcast! Teresa Moews Teresa Moews 2 years ago I love both of you, great message!! I am a cancer patient trying to use longevity to not have a 3rd recurrence. I would love to be part of a clinical study! I live in Michigan. 1 Your Name Here Your Name Here 2 years ago I've watched several of David Sinclair's interview's ahead of buying his book. This is was the one that made me think it was a worthwhile purchase. Thanks for treating your audience like curious adults and not something else! Stephen Ruane Stephen Ruane 2 years ago Thanks Rhonda and David - Really grateful to both of you for sharing the amazing work you do Richard Sheridan Richard Sheridan 1 year ago you two together are so fun to watch. This is absolutely incredible research and it seems like every other question Rhonda asks I was want to ask as well. Keep doing these videos and publishing your research. I am so excited! Adiudicium 1776 Adiudicium 1776 2 years ago Excellent discussion, really impressively done with the graphic and citations! 14 FoundMyFitness ⵣ=ⵣ -ⵣ-=-ⵏⵉ ⵣ=ⵣ -ⵣ-=-ⵏⵉ 2 years ago zillions thanks Rhonda, your advice on intermittent fasting helped me improve my kickboxing and resistance workouts,fat loss , muscle gain as well overall health. keep up the good work 1 trentriver trentriver 2 years ago FABULOUS BROADCAST! Please have David back - love your work, Rhonda! 12 FoundMyFitness aboodz aboodz 1 year ago Thank you Dr. Patrick and Dr. Sinclair for this truly exciting and informative discussion! Ka Nahn Ka Nahn 2 years ago This is by far the most detailed interview with Dr Sinclair that I've come across. Thanks for the great info!!! 1 Justin Bischoff Justin Bischoff 1 year ago This is such a great video. I love how papers relevant to the discussion are shown on the screen in real-time! 1 Daniel Evergreen Daniel Evergreen 2 years ago Absolutely amazing presentation. The long wait was worth it. 4 FoundMyFitness Sam Sam 2 years ago Thank you Dr. Patrick! Please keep these important podcasts coming. Mehdi BC Mehdi BC 2 years ago Such a great and informative interview. Thanks Docs! Daiki Daiki 2 years ago Appreciate all the editing you do for your videos Rhonda! 35 FoundMyFitness Konstantinos Theodorakos Konstantinos Theodorakos 2 years ago (edited) I really do appreciate that you include the related publications and figures during the video. I hope more will follow your example! 2 FoundMyFitness oltishqip oltishqip 2 years ago Thanks for this wonderfull interview Dr Sinclair.Wish the world had more folks than you. Wedge Pressure Wedge Pressure 2 years ago Rhonda thank you for doing these podcasts they are invaluable. 41 FoundMyFitness Satsang Launceston Yoga Sanctuary Satsang Launceston Yoga Sanctuary 1 year ago Thank you so much, I love this work and all the extras you've added to the conversation make it so much easier to digest :) NeonAera NeonAera 2 years ago Awesome discussion on longevity and NAD w/ David! Very compelling stuff going on with NR and NMN. It's good to know the stuff should be kept pretty cold. Anyway, great interview. The slides during the talk are very informative and helpful to understanding how the genes, and other pathways work. Thanks, FMF! FoundMyFitness Chad Aitken Chad Aitken 2 years ago This was one of the best interactions I’ve watched yet. Rhonda brought out the best in David. He’s been holding back. We need more like this, other than videos just for beginners. 5 Tony Westbrook Tony Westbrook 2 years ago So glad i found this channel and agree that this is the best interview i have seen of David's. Rhonda... all the documentation is awesome. Thank you both for such epic determination and knowledge. Joel G Joel G 2 years ago Rhonda presents us the glitterati of genetic health experts, and rightly so. Thanks so much to all these people for extending my life and enhancing my health (David totally put me onto sirtuin and mononucleotide stuff) . 1 Timo G. Timo G. 2 years ago My two favorite people talking about the topic aging <3 246 Serena Mari Serena Mari 1 year ago I've just discovered your channel and subscribed. This interview is amazing! I could understand all of it! Would have been nice to have live q&a Dennis Fink Dennis Fink 2 years ago Outstanding work both! Love your book Dr. Sinclair, your best interview yet Rhonda! 4 peckdec peckdec 10 months ago I really like that you have found a creative way to utilize the video format by including these snippets of relevant information, diagrams and studies! So far it is unique. Richard Richard 1 year ago Another stunning interview! Thank you for bring the groundbreaking research to our attention. SIncerely Richard Camila Azzini Dermatologia Camila Azzini Dermatologia 1 year ago Congrats for the amazing interview! Thanks for sharing your knowledge!!! Mikhail Belstar Mikhail Belstar 2 years ago Thank you for such interesting interview! Got a question👋🏻: Does it mean drinking resveratol and taking NAD+ supplements during fasting will boost autophagy without breaking the fast? 9 Mike Graf Mike Graf 1 year ago So amazing you both put the full episode and broke it down into useful clips. Please give a bonus to whomever thought of that! Giannis Christopoulos Giannis Christopoulos 2 years ago Epic and legendary video!!! Incredible amount of useful information!!! Thank you so much!!! 1 FoundMyFitness Madison Bear Madison Bear 4 months ago The information that is visually blended is very helpful and helps to really learn something whilst watching. thanks for the effort FoundMyFitness NihilisticAnarchist NihilisticAnarchist 4 months ago Mindblowing to hear Dr. Sinclair say no person had reversed their clock before he put his book out. omgmrtea omgmrtea 2 years ago Really appreciate all the work you put into these videos, with so much information on the side, on slides etc.👍👍👍 FoundMyFitness Ron D Ron D 2 years ago Thanks to David for sharing so much rather early ..that seems like part of the breakthrough; a protocol improvement! Thanks again Rhonda 8 KR KR 1 year ago Rather enjoyed this video. Was very impressed by the thoroughness of the conversation on such a complex and complicated topic. Very exciting research going on! 1 TheVodec TheVodec 2 years ago After watching both of these scientists on Joe Rogan's podcast, reading their research, watching their videos and reading Dr Sinclair's book I am excited to get some new information. Thank you Dr. Patrick!! Margics Margics 2 years ago Not possible to not like a chat with Prof. David Sinclair 😊 truly and the exciting cutting edge science on aging. The book lifespan is so brilliantly Interesting ..unbelievable, loving it and about to finish reading so it makes me thirsty for more 😁 truly! 2 David David 2 years ago (edited) Best interview with Dr Sinclair that I have seen since the Peter Attia podcast, loved the level of detail. Looks like I need to move from pure Resveratrol to trans-Resveratrol to harness the full benefit. Also.. FFS re: keeping NMN/NR cold and in the fridge/freezer. 15 Javier Solis Bolivar Javier Solis Bolivar 1 year ago Great information, thanks a lot for your amazing work. Gerald Rivet Gerald Rivet 2 years ago Great interview Rhonda. I've been waiting for this since January. David is such a classy guy. Thank you. 5 Michael James Michael James 2 years ago What an amazing gentleman doing astonishing work! Thank you for such a fascinating interview which kept me rapt from start to finish. Many screen caps of great plates to study afterwards: must have entailed so much work. Thanks again. 2 swenic swenic 1 year ago One of the very best YouTube vids I've seen, thanks. Great work! It's been 18 months, is there a follow up? Cloud Guru Cloud Guru 1 year ago It would be great to see a list of specific supplements that Rhonda and Sinclair suggest to boost NAD+ or even better overall supplement stack they both use. Eric McBrearty Eric McBrearty 2 years ago This interview is excellent. I'm only half way through and I'm having a brain orgasm. I have weeks of reading ahead of me. Thanks for including time stamp show notes, and adding in visuals during the conversation. " I have to interrupt because I get excited" I feel the same way David. Thanks Rhonda for such an information packed video. The video editing ( visuals) sets this interview apart from any other. It turns passive audio input into visual stimuli; creating additional memorization hooks. Great work all around! K G K G 1 year ago Such astounding work on this podcast as always Fun Guy Fun Guy 2 years ago OMG I'm excited to listen to this!! The whole time listening to him on JRE I was dreaming of a convo between you two. 64 Ja Wi Ja Wi 2 years ago Thank you...well done on a great discussion! 1 FoundMyFitness Aiko Morioka Aiko Morioka 2 years ago This is a power packed dialogue! Incredible information. It would be so helpful if you could include a transcript of your conversation. For us non scientists who are trying to understand The biochemical interactions that can help to stall the aging process, this would greatly enhance Our ability to comprehend and implement necessary changes and supplementation. Thank you for sharing this brilliant Interview! Rasmus Rasmus 6 months ago Rhonda, I would love to hear your thoughts on how to increase longevity with type 1 diabetes. As taking exogenous insulin seems to be the worst thing ever for a long healthy life. Elvay Elvay 1 year ago Great interview. Watched it a year ago and came back today for a refresh. The book is a good read too. Karen D Karen D 2 years ago Fascinating! Thanks for making this high level information so digestible (ish)I’m 52 and joking ask is it too late for me to go back to school and become a doctor or scientist? I’m Obsessed!! Love your channel! Tu Nguyen Tu Nguyen 2 years ago This should be required watching in all high school science class. 54 Sebastian Niemann Sebastian Niemann 2 years ago Amazing interview - thank you 🙏 2 thighdude7 thighdude7 2 years ago I'm really going to have to listen to this multiple times to fully absorb this. Thanks for the content, much appreciated! 1 Anthea Ng Anthea Ng 1 year ago Yes, I take resveratrol in biogel form in a sachet - it's gone through cap-E test as well... showing the high percentage of antioxidants as well in the superfruit product :) 2 Yayang Tapir Yayang Tapir 10 months ago (edited) Wow! Telling sirtuins to stop overworking, wasting energy and go back to where it was 20 years back. I'm so excited.👍 Thank you doctor. 1 Bruce Miller Bruce Miller 2 years ago (edited) Well done! I started taking a few supplements three years ago at age 70 - B6, B12, Folate, high dose D with A. Immediately felt better. By "feeling better" I mean this: improved mood, clearer thinking, fewer aches and pains and relief from SAD.Tests revealed the supplements raised B & D in my body from "normal levels" to "optimal levels." Added an NAD supplement two years ago and in a short time felt even better - again using the listed personal criteria. Also noted that almost immediately, BP, which was rising, fell back to normal levels. The effects of supplementing B6, B12, D with A and NAD supplement continue. I believe if this was "placebo effect" the results would have faded. Added 16/8 intermittent fasting three months ago. I feel even better! Dropped 12 pounds and blood glucose dropped from borderline high to normal. A constant from before & throughout this period has been fast-ish walking - 3-6 miles a day. Will be adding Resveratrol (micronized) to this regimen shortly. 1 Nick H Nick H 2 years ago Rhonda is so freakin funny 😂..together with incredible knowledge, always makes these interviews even better than most. 5 R Hurrell R Hurrell 2 years ago Great interview. Two lovely people doing great work! Brogan Josh Brogan Josh 1 year ago Love these two. More Roganlings finding their own feet in the podcast world. 1 My Tube My Tube 1 year ago This was a GREAT interview. I was wondering if you've heard of 'Berberine'? Its a natural (and possibly more powerful) alternative to metformin. 1 Dr Nick Engerer Dr Nick Engerer 2 years ago I love the high five 🙌🏻 - these developments are totally awesome & worth celebrating 1 Abudalkhalek Hussien Abudalkhalek Hussien 2 years ago This is an amazing and informative interview ... however its true that Shannon gave us a formula to calculate channel capacity, but he didn't propose the TCP/IP protocol, anyway such cool analogy from Dr David. aquapurity aquapurity 2 years ago (edited) It's so great to receive the slides/written info during the talk. I pause and read and then more deeply comprehend what's being said. What an education! Thanks Dr Patrick. If I could have it all my way I'd include a little 'picture in picture' in the bottom right hand corner so we can still see the conversation video on full slide pages. 5 FoundMyFitness alphamale3141 alphamale3141 1 year ago The notes on the screen were really helpful. Although there are many informative videos on YouTube, none have even been close to this one. Many thanks. sketchur sketchur 9 months ago It's so hard to believe Dr. Sinclair is in his 50s. I hope he lives a long, fulfilling life. And I hope he doesn't die from cancer. Ariel Luna Ariel Luna 3 weeks ago This the best David Sinclair interview that I have seen or heard. Thank you rhonda. JonJonFilms JonJonFilms 2 years ago I need more of these!!! this was so great P X P X 2 years ago I really like your summarized highlight or key figures, well-done job! 2 Antonio Mele Antonio Mele 2 years ago Been waiting for this one! Can’t wait to listen. Thank you for the content! 4 D Dutton D Dutton 1 year ago Five star interview. Dr. Patrick is probably the best interviewer in this field. Prof. Sinclair is the leader in this field. I stopped taking NR a couple of years back because of leg cramps a couple of hours before rising. I also have leg cramps on NMN but less often. I would like to hear from others who had cramps. Regards Claudette Sechler Claudette Sechler 1 year ago What a great interview! Lelija Roy Lelija Roy 2 years ago Outstanding interview...thank you valar valar 2 years ago This is a much less awkward interview than the one she had with Aubrey de Grey on the same subject. It helps a lot that David Sinclair is apparently genuinely as concerned with healthspan as lifespan and actually looks after himself, instead of just drinking and doing nothing else like de Grey. (And de Grey is brilliant, don't get me wrong.) MT HA MT HA 1 year ago Excellent interview, amazing information. Unfortunately the NMN that I purchased give me hot flushes and upset stomach, making me more tired. Has anyone experience this? Katarzyna Hansen Katarzyna Hansen 1 year ago (edited) I just love David Sinclair. We take NMN and resveratrol since January and can see fantastic results. Thank you David! 4 Commandercod 2016 Commandercod 2016 2 years ago Great interview! Changing the world! SubtleReed SubtleReed 1 year ago This lady is well informed and displined. 1 rudyin thesky rudyin thesky 8 months ago I love the way you show pertinent notes as the interview proceeds. C0nstellati0ns C0nstellati0ns 2 years ago So interesting! Thanks for providing this content! Anolis A Anolis A 2 years ago I was hoping you’d get David Sinclair on! Fantastic talk! 1 Dany Cervantes Dany Cervantes 2 years ago (edited) I’m really hoping we start using these genetic treatments within the next decade, in the 2020s, and not just still talking about it. Life Code. It’s more exciting than computer code. 76 Trey IM2 Trey IM2 2 years ago Gawd, listening to these uber deep and technical conversations make me regret not going into biology, even if I have no clue as to much of what is being said. Lol. While I loved science overall compared to my other subjects in school, biology has been the most fascinating to me. CNRAKABOSS CNRAKABOSS CNRAKABOSS CNRAKABOSS 2 years ago David Sinclair is a smart guy... What does he take daily as supplements? I am so interested in what he and what he has his father take daily/weekly. I think it would really tell a story. Yashin Shekh Yashin Shekh 1 year ago amazing information as always :) Richard Ayala Richard Ayala 1 year ago (edited) A little over my head, but I understand some due to other lecturers and a few books! I will learn more as I follow you two doctors of Philosophy! My newfound interest at 72; never too old to learn! I’ve got your book, Dr. Sinclair...Lifespan! Kim Davis Kim Davis 1 year ago Thank you sooooo much ... incredible info 👍👍 Phuskooz Phuskooz 2 years ago I’m pretty sure this guy determines his age off of his biological age instead of how many times he’s orbited the sun. He’s said he was 51 in one interview and he’s been “almost 50” for quite a while now. 4 Todd Whitbread Todd Whitbread 1 year ago He’s so used to having to present his work in layman’s terms for everyone, he gets so excited when she uses scientific words and he can talk full nerd with her 1 everettesfit everettesfit 2 years ago Love your videos and information. FoundMyFitness Zanger Victor Zanger Victor 2 years ago Very interesting as usual, but can you talk about the cancer risk of NMN sometime? I read about that more and more, which made me quit NMN. That’s not what we are looking for right? Thanks for all the great video’s. Chapters Introduction 0:00 Activating longevity genes 0:36 Sirtuin activation 5:02 Fasting, caloric restriction, and exercise 7:19 NAD 10:56 Resveratrol 16:00 Epigenetics 20:00 Boosting NAD 36:22 Excess calories accelerates 41:11 Resveratrol slows aging 44:26 NR & NMN in aging 51:00 Sleep improves glucose metabolism 1:00:05