Reverse Aging 21,796 viewsMar 1, 2022

Scientists Uncover How to Reverse Aging 21,796 viewsMar 1, 2022 Sciencerely 32.1K subscribers Scientists have successfully increased the lifespan of animals and there are first studies which describe how we might reverse aging. So how could we one day rever aging? 🔬 Subscribe for more awesome biomedical research: https://bit.ly/2SRMqhC 📸 IG: instagram.com/clemens.steinek 🔬Twitter: https://twitter.com/CSteinek In the 70s, scientists observed that cells only grow for a limited amount of days in the laboratory (Hayflick limit). Over the years, so-called hallmarks of aging have been uncovered. These hallmarks of aging govern how our cells age and we could try to slow dem down to "reverse aging". The first hallmark of aging is mutation. We can acquire mutations by being exposed to UV radiation or certain chemicals or through cell division. Cell divsion also leads to a second hallmark of aging (telomere attrition). Furthermore, our mitochondria start to work less as quality checks do not work properly anymore. The hallmarks of aging are tightly linked to epigenetics. Epigenetics means that we have mechanisms (DNA methylation, histone modifications) which regulate the activity of genes. Epigenetics governs the development of embryonic stem cells into cells of our body but also impact aging. The loss of mitochondria for example is linked to dysfunctional epigenetic layers. As we age, at least three epigenetic modifications namely H4K16 acetylation, H3K4 trimethylation, or H4K20 trimethylation acumulate. The thing is that epigenetics is reversible... so can we also reverse aging? Diets have been shown to slow down (and reverse aging to a small degree). Cells also show less damages in their DNA and we find higher levels of proteins which are found in "young cells”. The activity of mitochondria is also increased if we undergo caloric restriction. Diets also impact the production of sirtuins which increase the lifespan and reverse aging. Different compounts (such as NMN and remodelin) have been shown to improve the epigenetic landscape which might have an effect on reversing aging. Exercise also might help to reverse aging as it helps to increase the activity of mitochondria. Meditation and having less stress also helps to increase the lengths of telomeres which might help to reverse aging. All in all studies suggests that some hallmarks of aging can be reversed so lets see where that goes! 0:00-0:46 Intro 0:46-3:53 Hallmarks of Aging 3:53-6:38 Epigenetics Controls Genes 6:38-8:45 Reversing Aging: what is known 8:45-11:25 Reversing Aging through Diets & Sports 11:25-12:13 My Opinion References: https://journals.plos.org/plosone/art... https://reader.elsevier.com/reader/sd... https://www.frontiersin.org/articles/... https://www.frontiersin.org/articles/... https://www.sciencedirect.com/science... https://www.ncbi.nlm.nih.gov/pmc/arti... https://journals.plos.org/plosone/art... https://reader.elsevier.com/reader/sd... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.mdpi.com/2072-6643/12/4/1194 https://www.ncbi.nlm.nih.gov/pmc/arti... https://onlinelibrary.wiley.com/doi/a... Images: Some pictures were derived from Servier Medical Art by Servier. You can find over 3000 free medical images here: https://smart.servier.com/ Infected cells by Beachfront, CC BY 3.0 Drosophila by Kersti Nebelsiek, CC BY 3.0 Hayflick limit by Azmistowski17, CC BY 4.0 Conrad Waddington by https://www.che.ac.uk/what-we-do/conr... , CC BY 4.0 Breast tissue necrosis by Calicut Medical College, CC BY 4.0 Music: Title: Art of Silence by Uniq https://soundcloud.com/uniqofficial Title: Punch Deck by promoted by BreakingCopyright: https://bit.ly/bkc-ethereal2 (CC BY 3.0) Title: Black heat by Ross Budgen (CC BY 4.0) Title: Filaments by Scott Buckley d (CC BY 3.0) Title: Rudolph by Lukrembro https://soundcloud.com/lukrembo Light Sting by Kevin MacLeod (CC By 4.0) Source: http://incompetech.com/music/royalty- ... Title: Buddha by Kontekst Genre and Mood: Hip Hop & Rap + Bright Artist: http://incompetech.com/ About Clemens Steinek: CLEMENS STEINEK is a PhD student/youtuber (LifeLabLearner) who is currently conducting stem cell research in Germany. Chapters Intro 0:00 Hallmarks of Aging 0:46 Epigenetics Controls Genes 3:53 Reversing Aging: what is known 6:38 Reversing Aging through Diets & Sports 8:45 12:13 My Opinion 11:25 141 Comments rongmaw lin Add a comment... Astral Wound Astral Wound 4 months ago Good video. I'm probably in the minority, but I would absolutely let myself be genetically modified to reverse my aging. I'd be first in line for that clinical trial. 89 Sciencerely Trend101Warrior Trend101Warrior 3 months ago The mainstream media needs to get on board with this anti-aging research. Too many people are conditioned to think aging is natural and barely anyone notice it. 31 Lukas M Lukas M 4 months ago "We do not want to genetically modify ourself..." yes we do, at least some. If you have a chronic genetic disease you become quite more tolerant of that thought. 61 Sciencerely CubaHubbaBubba CubaHubbaBubba 1 month ago (edited) I'm 28 years old, growing up as a kid I always wanted to learn why we age and why my parents got old and weak. Now I'm starting to see myself get older and it's not nice to know that I'm no longer 21 where I didn't care about aging or anything. I researched it all my life and would love to become a professor and help young people becomes graduates in biological science. The more people want to work to eliminate disease the higher chances we will be able to achieve it. I don't want to die at 70 it's early I believe time goes quick and we age quick 10 om1gee om1gee 4 months ago (edited) Definitely an interesting topic. Not to get the chance to follow science (and Sciencerely) longer and see all the fancy stuff from 2100 but also to reduce the chronic pain in the later part of our lives. So yeah, wouldn't mind if you dig deeper into this topic :) 6 Sciencerely J of BEATS J of BEATS 2 months ago Great video sir. I agree with the end part of the video I could see us all probably extending our lifespan like even pass 100 but as for stop aging entirely I don't see that happening. Especially since we all know that nothing last forever in this whole planet yet alone our universe. I think I'm fine with living even with aging, it's a part of life. 1 Sciencerely Aliciagny Aliciagny 2 months ago Wow, great video! I always wondered why I look so much younger than I am. No one in my age group looks as young and I don't have the health problems they do. Everything you said made me realize why. So I don't just look younger my cells really are younger! That's the best news I had all day! I will keep doing what I'm doing and live a really long time! Hopefully. 💗 1 Sciencerely Jon Reiser Jon Reiser 3 months ago Well done. This presentation was not too dumbed down, yet not so overly comprehensive as to be too complicated to understand. I would be interested in another video like this that takes just a little deeper of a dive into the subject. This information has been offered many times on YouTube. I can’t stand to watch the scientist who gets into concepts that require a graduate degree in order to understand. However, I would like to understand more. Sciencerely Nima Fouladi Nima Fouladi 3 months ago I really enjoy all of your content, please keep it up! 1 Sciencerely Kasu Kasu 4 months ago Great video! Keep the high quality content coming! 2 Sciencerely MrGriff305 MrGriff305 4 months ago Dang I really hope they bring this to market in the next 25 years. 4 BlackShadow BlackShadow 4 months ago Are you familiar with a compound called Resveratrol? Its been shown to activate Sirtuin1 and there are some interesting trials regarding longevity in model organisms. Sadly there are no large scale human trials yet and the overall situation regarding high quality studies is more like meeh... 7 Sciencerely evolve evolve 4 months ago (edited) Your channel rocks! Great quality videos. :) Thanks 2 Sciencerely 🌟 Wander the Nomad 🌟 Wander the Nomad 4 months ago (edited) Since we seem to only be able to reduce aging, but not prevent death entirely, I wonder how dying by old age will be like for people who have reduced aging. Will it just be the same as we know it, but just moved later on in time? Will death by old age be more comfortable for people who have reduced aging? Or will it feel the same as normal deaths by old age? 1 Gregory Malchuk Gregory Malchuk 4 months ago There needs to be an Apollo Program/Manhattan Project level crash program to develop life extension technology. Though first I suspect we are going to have to force society to view aging as a problem in the first place. You can't solve anything if you can't identify and define the problem. 9 just thinkin' just thinkin' 1 month ago Great video. Please elaborate on the study on mice. I read that before and it was fascinating Odessa Smith Odessa Smith 4 months ago So if red light therapy causes cell division, which the makers of the panels promote as a good thing, why would it not in fact actually be a bad thing as too much cell division or premature cell division is actually a sign of ageing? 1 Satya Supteshu Jagarti Satya Supteshu Jagarti 3 months ago Yes please continue this series Mohammed Aslam Mohammed Aslam 2 months ago At last you said, we probably won't become immortal :'c We all want to be and would happily pay for it as well. i wanted to save the world i wanted to save the world 4 months ago how much fasting? ketosis for 1month every year? does weather affect anything? 4 Nemanja 369 Nemanja 369 2 months ago What some people don't understand about reversing aging is not just about extending quantity but rather improving quality of life. I would rather live 90 years feeling like in my twenties the whole time, than to live in pain, lack of strength, flexibilty and energy half of that lifespan.. Only a young ignorant fools or religious fanatics would be against something so good and logical for humankind. 2 Olivia Miller Olivia Miller 2 months ago People who say they don't want to live forever should still support this because you can always change your mind later but not if you're already dead. I have been saying this... longevity is our choice! If we want to sustain our health, we have to do something about it! This will start by knowing what supplies our body needs. Start by eating a balanced diet, quit vices, exercise regularly and take an NMN supplement. Mine is a 500mg per day, NMN by Vitruvin Nutrition. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. See your result and tell the same experience. SuperBigwinston SuperBigwinston 3 months ago (edited) What about serious brain damage that happened 25 years ago. Could that be reversed and cured. Bieke Hamers Bieke Hamers 2 months ago Redox is the only way to become younger again and healthy 🙏🙏 2 Lit SRT Family 2 Lit SRT Family 22 hours ago I will be back to this video in year 2100 to see if your right 💯👍 Sciencerely M M M M 11 days ago please update your information regarding dietary fat. Natural unadulterated dietary fats are not only healthy, they are essential. Limitless Joseph Limitless Joseph 2 months ago (edited) Hope this common dangerous disease is fully eliminated in the future probably around 2-3 decades. I 1000% agreed that biological aging has to be stopped as soon as possible therefore think about our grandparents passing away due to their aging and is highly unfair for grown up or adult children seeing her/his parents encountering this sick minded disease. For my perspective is that every time I see couples having a child or more than one therefore I’m continuously jealous that they’re both young and beautiful and it makes me want to go back in time and fixing my mistake but is alright growing as a person is more better or a valuable asset. To recap here is that highly unfair for example a daughter or son who is about or already have an incredible job but suddenly seeing one of their parents passing away and this is the one thing I’ve always hated and annoyed the most because why cannot every single member of the family became young, beautiful and have an exciting life?! Please do not be alarm I’m just saying here. itsmebryang itsmebryang 3 weeks ago Got old by 12:13 minutes watching this - MF how to reverse UnformedBog9059 UnformedBog9059 2 months ago Jesus loves you ❤️ 5 Hu Tao Hu Tao 12 days ago Only Allah can grant Eternal life 1 Mr. Pizza Marlon Mr. Pizza Marlon 2 months ago The Bible teaches us that God created man to live forever. His plan did not change and we will live forever if we listen to him. Enjoying life, not just for a short time, but forever (PSALM 22:26). Soon we will hear the [announcement] of peace and security. The new world is near. Are you ready? 2 Hassnain Ali Hassnain Ali 1 month ago "Each soul shall taste death". So get yourself ready for the hereafter, no escape 1 Hello DG 123 Hello DG 123 2 months ago Hahaha I wanna work my whole life too :) 1 ScarlettM ScarlettM 2 months ago 11:39 - any reason why not? You kinda skipped that. Shanbor Shangpliang Shanbor Shangpliang 1 month ago We'll..its brilliant idea or breakthrough if this ideas become a reality..Age reversing hmmm..but what if we can't stop the reverse process ..what if it keeps on reversing until we becoming as a child or even baby once again.. hahaha it sounds funny ryte but using drugs or chemical it might happen u know.. 1 Hello DG 123 Hello DG 123 2 months ago I was 16 when he passed away Marius Marius 2 months ago You think the general population would be granted access to this medicine though? Flatbed hauling with scott N Flatbed hauling with scott N 2 months ago Definitely would be first in line!! Sign me up already! Kasim Kasim 4 months ago didn't expect to hear about nfts here 😂 naturalwalker naturalwalker 4 days ago Cherish youth trust Old age+ native Proverbs 1 Situation room Situation room 2 months ago The goal is not to be immoral but to die of old age’s instead of degenerative disease. 3 DumpHae DumpHae 2 weeks ago i got one haha Wolf in the Suit Wolf in the Suit 1 month ago Lemme guess you will tell me stop my cola and burgers diet evolve evolve 4 months ago We could live to a thousand years old is my guess... hard to push further then that. sopark434 sopark434 3 months ago Fats are not bad. Sugar is the killer. 5 Vivian Vivian 4 weeks ago This is not for 8 bilion humans....wake up!!! Vivian Vivian 4 weeks ago Please test Pelosi, Soros, Quene Elizabet.... Hello DG 123 Hello DG 123 2 months ago So umm after the iPod the iPhone and the iPad Steve passed away???? 1 Mark Lindz Mark Lindz 1 month ago Let me know when you figure it out Ronald Price Ronald Price 3 months ago ｐｒｏｍｏｓｍ Hello DG 123 Hello DG 123 2 months ago I was in school. Katy Mac Katy Mac 12 days ago Sign me up!! Hello DG 123 Hello DG 123 2 months ago Hahahahah Immortality Immortality 4 months ago ☠ Hello DG 123 Hello DG 123 2 months ago Hahaha woooo Hello DG 123 Hello DG 123 2 months ago Uncle Steve??? :) ooooo Hello DG 123 Hello DG 123 2 months ago Heyyy bill gates windows!!!!!!! BJ Horse BJ Horse 1 month ago Bull talk talk talk Darrell Nypaver Darrell Nypaver 2 months ago Horrible video. Difficult to understand because of the heavy accent.