Epigenetics #Longevity #DNAMethylation Epigenetic Aging: How old is your DNA? 66,323 viewsDec 15, 2020

#Epigenetics #Longevity #DNAMethylation Epigenetic Aging: How old is your DNA? 66,323 viewsDec 15, 2020 3.8K DISLIKE SHARE DOWNLOAD CLIP SAVE FoundMyFitness 426K subscribers Dr. Steve Horvath, a professor of genetics and biostatistics at UCLA, has found a way to measure biological aging – a type of "clock" – based on the methylation pattern of an organism's genome. Methylations are biochemical processes that modify the activity of a DNA segment without changing its sequence – a type of epigenetic change. This video primer explains the basics of epigenetic clocks, the topic of our interview with Dr. Steve Horvath, coming soon! Get the show notes here: https://www.foundmyfitness.com/episod... Episode chapters: 00:00 - Biological vs chronological age 00:40 - Estimating biological age with epigenetics 01:17 - The Horvath clock 01:54 - The GrimAge clock 02:19 - Altering biological age About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California, San Diego. She has done extensive research on aging, cancer, and nutrition. It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach. Learn more about Dr. Rhonda Patrick and her mission for FoundMyFitness at www.foundmyfitness.com This episode was fiscally sponsored through The Film Collaborative and a grant from a generous anonymous donor. https://www.thefilmcollaborative.org #Epigenetics #Longevity #DNAMethylation Chapters Biological vs chronological age 0:00 Estimating biological age with epigenetics 0:40 The Horvath clock 1:17 The GrimAge clock 1:54 Altering biological age 2:19 Featured playlist 31 videos Just Me FoundMyFitness 317 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 1 year ago Interview with Dr. Steve Horvath coming out next week. Let's get 2021 kicked off with a bang with a whole bunch of great new videos. Don't forget to like and subscribe and maybe even switch the bell notification to the on position. Show notes for this primer here → https://www.foundmyfitness.com/episodes/epigenetic-clock 66 FoundMyFitness John John 1 year ago I taught courses in biological, marine and environmental sciences at the college level ... before I retired (20 years ago) I developed a course: The Biology of Obesity, Ageing and Disease and have followed the research in these areas ever since. In my estimation Drs. Rhonda Patrick and Valter Longo are absolute leaders in the field in presenting emerging scientific research in terms understandable by anyone. 18 FoundMyFitness Future Point. // Luis Angel Future Point. // Luis Angel 1 year ago I love these infographic style videos. They're so engaging. 50 FoundMyFitness Antonio Mele Antonio Mele 1 year ago Rhonda, this video is fantastic! You have made massive improvements since your original videos on magnesium and athletic performance. Congratulations! You are on your way to becoming one of the most influential science communicators of the 21st century. 5 FoundMyFitness The Sheekey Science Show The Sheekey Science Show 1 year ago Epigenetics is the reason I decided to specialise in Biochemistry . 89 mcgeebag1 mcgeebag1 1 year ago Great content as usual and very nicely produced! 5 FoundMyFitness Tim Burke Tim Burke 1 year ago I love your videos, your enthusiasm for helping people is so admirable. 4 FoundMyFitness Robert Wadlow Robert Wadlow 1 year ago Thanks for all your work breaking down the science on topics for some of us lay people. I enjoyed watching your tryptophan metabolism and fish roe videos. I have now added that to my diet. Any new insights on the potential advantages of that over regular fish DHA? Also, could you do a video on the benefits or Red Light devices? Reza Vaziri Reza Vaziri 1 year ago What are your thoughts on David Sinclairs work on OSK-induced epigenetic reprogramming? It sounds like a pretty unique way to achieve the desired methylation patterns, and strengthens the the case for a correlation between epigenetic age and biological age. Thanks for posting more epigenetic content! Higher Resolution Higher Resolution 1 year ago Excellent presentation. Much appreciated. Fascinating subject. Apart from methylation of histone proteins, 8 of which form the basis of chromosone packaging when the double helix of DNA wraps around themj, histone modification also takes place at different locations on different amino acids in the form of phosphorylation, acetylation, ubiquitylation and sumoylation. By no means is methylation the only game in town. BapCorp BapCorp 1 year ago This research is Amazing, look forward to more. We are told that heat stress is extremely positive for the body. Bloodsport Bloodsport 1 year ago Your the best Rhonda. You make it look easy, keeping it clear and easy to follow ❤ Anishesh Das Anishesh Das 1 year ago Thank You, Dr.Patrick. I recently stumbled across your channel and I have been on a spree since then. Thank you for putting such amazing content out here for free. Larry Kraft Larry Kraft 1 year ago Loved the playful P.S. at the end of this video. Given that you, “turned up [your] heat shock proteins”, yes, I imagine you must have changed your epigenome. Thanks as always for your evenhanded explanation of the science that is being done in this area. Thanks also for the reminder that I intended to get a sauna after seeing the evidence you shared about that before! Vishnu Krishnaprasad Vishnu Krishnaprasad 1 year ago Love the short videos, please make more of these from the longer interviews with specific topics 3 FoundMyFitness Dax Barlow Dax Barlow 1 year ago (edited) Great , clear , at moving pace to absorb information, thank our Dr. Patrick. Layout of information w/ graphics to me with a form of dyslexia makes for attention getting Video . Please keep it coming and enjoy your interviews . 5 FoundMyFitness Michaela Lawson Michaela Lawson 1 year ago She is getting much better at relaying this information in layman's terms ❤ Can I ask my Family doctor to order me some of these tests? 😊😊 13 FoundMyFitness Cheryl Negus Cheryl Negus 1 year ago Absolutely brilliant, thank you so much DrRhondaPatrick for sharing your genius with us. ComedyJesus ComedyJesus 1 year ago Another outstanding video, thanks DRP! Michael Angelillo Michael Angelillo 1 year ago Will be interesting to see, although will probably take decades of epidemiological research to confirm if epigenetic age is a proxy measure or an actual measure of life expectancy, i.e. if improving your epigenetic age actually improves how long you'd live then it's a true measure. Although I bet life insurance companies will love to have an even more accurate method to predict individual age of death outside of accident. AtlanticPuffin AtlanticPuffin 1 year ago Can't wait to see the interview, I'm really excited to learn more about this topic 4 alexnickolaev alexnickolaev 1 year ago (edited) Awesome visuals. And awesome news. Thanks for your work Rhonda! M. McGui M. McGui 1 year ago Dear Dr Rhonda, It seems that you geared up the stuff; the content format! I am looking forward to see you enlightening us with your humanistic work with also other practices and molecules such as Honokiol, berberine, hydroxycitrate and so forth! Best, FoundMyFitness SnorgonOfBorkkad SnorgonOfBorkkad 1 year ago Wow, someone got a motion graphics animator to help them out. Very ambitious. Looking forward to all the new video styles you'll be experimenting with. 4 Steve Diben Steve Diben 1 year ago Love the production quality of the video! 14 Keep Me Keep Me 1 year ago You hit it out of the park Rhonda. I was wondering on a loosely related note: do you think I could get away with a mustard seed capsule taken right after my broccoli sprouts or does it need to be blended into the smoothie? I want to take my sulforaphane optimally, but I’m having a lot of trouble getting down that spicy taste. Neobellator Neobellator 1 year ago 😮 Really interesting! Great work with the infographic. Makes things easy to understand. 👍 Anthony L Anthony L 1 year ago Outstanding video Dr. Rhonda Patrick! I’m sitting in the sauna right now! Great work, and thank you for Inspiring so many lives for the better. Melissa Costin Melissa Costin 1 year ago Great info, clearly explained..sharing ..I'm wondering if you've looked at ox DNA ie hydroxylation as also accelerating aging ...hence value of antioxidant rich whole foods ..I reccomend you look at cannabinoids as fat soluble membrane components which prevent oxidation and thus DNA damage ..might pitch the clock to cannabis industry looking at research ..thinking topicals on sundamged skin cropping SCC would be great patch to test prevention and treatment of senescence / advancing oncogenesis ...I'm glad my myotherapist Reccomended your channel .. 1 philosophical monk ,Achu philosophical monk ,Achu 1 year ago Nice information,video editing is quite a lot improved....makes it easier to understand.. Thank you for sharing ma'am 1 FoundMyFitness Chef Tony Chef Tony 1 year ago I can't wait to see the upcoming interview you mentioned. 49 FoundMyFitness TMPCarbs TMPCarbs 1 year ago Great video. Excellent lighting and composition. I like the background music. 20 FoundMyFitness Fabian Wahle Fabian Wahle 1 year ago Love the animation upgrade :-) (and the content as always) 1 tjames22123 tjames22123 1 year ago Definitely changing it for the better, Dr Rhonda!! Basing that off your enthusiasm levels! 1 FoundMyFitness Arnav Deshpande Arnav Deshpande 4 months ago Amazing. Short. Crisp. Loved it qm m qm m 1 year ago Yes, I do think the sauna is changing your epigenome! Thanks for the awesome video. I look forward to the interview with Dr. Horvath! shiftychance shiftychance 1 year ago I'm a full believer in epigenetic changes affecting biological age. This is based on my experience with the antibiotic Levofloxacin, an adverse reaction to it, and research pointing to intracellular epigenetic changes being a likely cause of the side effects. Unfortunately this is more like an accelerated aging experience rather than a decelerated one. Trust me, feeling like you aged several years in a span of months is not a good experience. Super excited and hopeful for this research to progress, it's super important! Greg Pace Greg Pace 1 year ago Took two tests! DNAge said I was 65 and Elysium's Index said I was 49. That is a 16 years spread. Which test is most reliable? 1 masa26762 masa26762 1 year ago Thanks! The video and the graphic really helped me understand this. It's hard to come by youtube video that's this complete. Bakhtiyar Neyman Bakhtiyar Neyman 1 year ago Words cannot express how excited I am about this! I notice that this video doesn't mention NAD boosters, hope you cover this topic in the interview though! FoundMyFitness Sleep Smart Smash Stress Sleep Smart Smash Stress 1 year ago The question whether turning back or slowing the epigenetic age is congruous to the biological age must be answered in the affirmative for the entire concept of Hovarth clock to carry any practical significance otherwise it is an exercise in futility or a purely academic curiosity. Let us study the relationships between epigenetic senescence to telomere attrition rate, neurogenesis rates and inflammaging intensity to uncover some more secrets of aging and age-retardation or reversal. Let us be content with seriously halting the speed of aging and inflammaging which tragically is picking up pace with a vengeance around the globe. Even that would be a highly desirable outcome. Noteworthy also is the fact of 60 years or 3 generation lags in the epigenetic signals for manifestation in full which is reminiscent of a similar 4-6 decade lag in the manifestation of impact of GHG elevation. Tryptamine Nurse Tryptamine Nurse 1 year ago Dr. Rhonda Patrick is 42 and looks like she’s 32. Thank you for all of this life saving information Dr. You are helping thousands around the world. Diego_Sarka Global Diego_Sarka Global 1 year ago I'm excited to learn more! Dr. Rohnda, looking forward to the interview! Michael Wilson Michael Wilson 1 year ago I did my genetic makeup test with ancestry. Would I be able to use this data with the grim clock to find out my epigenetic age? 3 T. C. T. C. 1 year ago Very cool research! Thanks for the video. 1 FoundMyFitness Catalytic Centaur Catalytic Centaur 1 year ago Thanks, Dr. Patrick, for this/your presentation. 2 FoundMyFitness Xavier Ghazi Xavier Ghazi 1 year ago (edited) Exciting to say the least and looking forward to watching the interview. A note in passing though. I wish there was no background music added to this introduction video or any other similar videos. I struggled to listen to what you were saying with the interfering music on. I suffer from Misophonia (literally hatred of noise) and this condition is more common than many suspect and noise/sound make us immensely uncomfortable. Thank you either way. MOONOOM MOONOOM 1 year ago Awesome video, Rhonda! Have you heard about Cipro toxicity? Do you know what to do about it? Sleep Smart Smash Stress Sleep Smart Smash Stress 1 year ago What are the proposed units that Dr. Steve Horvath, would advance as we measure biological aging? For uniformity and replicability of reserach among various groups there would be a need to develop a universally accepted unit for the biological or DNA/epigenomic age. CHANNEL AA CHANNEL AA 1 year ago Great presentation as always. However, background music a bit irritating though. Thanks. antokindness antokindness 1 year ago Fantastic, as usual of you! Kral Kral 1 year ago Rhonda, i don't if you upped your skin-care game or actually reduced your biological age but you look soo healthy and fresh in this video which makes me produce lots of serotonin alongside the trajectory that aging research and awareness is gaining! Maybe 2020 isn't so bad! 😁 1 Brown Bomber Brown Bomber 1 year ago Excellent video all the way around 2 FoundMyFitness Timothy Miz Timothy Miz 1 year ago Dr. Rhonda is always on point! She breaks it done better than anyone on the subject of aging. John Tibaldi John Tibaldi 1 year ago I love this style of video! FoundMyFitness susy may susy may 1 year ago Well done lead in to your personal introduction and content. 266941 2596419 266941 2596419 1 year ago Great content!! Yung Kashta Yung Kashta 1 year ago Question. When you guys use inconclusive studies as a a marker in progress in science , do you also factor in the people of different blood types might have different needs biologically? Or do these studies just pick random people and don't compare things like blood type, heritage, and environmental influences? Keep Moving Keep Moving 1 year ago Well done! Sleep Smart Smash Stress Sleep Smart Smash Stress 1 year ago With due respect to the learned Dr. Patrick, I would take issue with the remark - "Everyone's chronological age increases at the same speed" as speed measures distance travelled by a moving objec over a unit of time. Chronological age is simply statement of time lapse since birth (Koreans begin to count from the time of concption of the fetus btw.) so calling chronological aging speed is a misnomer. The concept of stated age since birth needs to be stated better.