David Sinclair | Why We Age and Why We Don't Have To | Talks at Google

Talks at Google 1.7M subscribers David Sinclair, professor of genetics at Harvard Medical School, discusses his new book "Lifespan", which distills his cutting-edge research findings on the biological processes underpinning aging. Sinclair describes lifestyle hacks we can undertake now to combat aging, as well as future scientific breakthroughs that promise to slow down—and even reverse—the aging process. Moderated by: Sam Phippen Get the book: https://goo.gle/2LXCd2P 3,394 Comments rongmaw lin Add a comment... LIFE OF GREATNESS LIFE OF GREATNESS 2 years ago 50-year-old dude that looks 20 and talks about living forever? I'm all ears 1.5K Ole Fella Ole Fella 1 year ago ❤️🎉 Eat healthy, do exercise, take vitamin tabs and sleep well. That's what I've done and it's my 90th birthday next week. 😊 750 Sibel Sibel 1 year ago Once again, science has cured every illness known to mice.. 541 V M V M 1 year ago David Sinclair's talk in 2250: "Why We Don't Age and Why We Have To." 788 Ilse Aschenbrenner Ilse Aschenbrenner 2 years ago Interesting the comment on fasting. When I was a child I had quite severe asthma and eczema. The nail on my left hand index finger was buckled with a cakey something underneath it. My sister used to tease me... I'd never get married with those hands... lol.. kids. At age 11 I decided to fast once a week. Missed breakfast and lunch, just took a thermos with hot water with lemon and honey in it to school every Monday. Had a cabbage and carrot salad with a light lemon and oil dressing and then cooked non starchy vegetables around 4pm when I got home from school. By the end of the year I had no asthma or eczema and my fingernail had grown normal like the others. 329 OPEN MIND OPEN MIND 2 years ago This guy is 50.... It seems like his methods are legit 1.5K Terri Ann Smith Terri Ann Smith 1 year ago Sinclair looks almost exactly like a younger version of Christian Slater who, coincidentally, is the same age. 135 Greg Nixon Greg Nixon 1 year ago (edited) I’ve watched many lectures. The common message is fast regularly, walk often, have good friendships, and avoid simple carbs. 110 Helios TXG Helios TXG 1 year ago I'm not afraid of death, I'm afraid of being trapped in a hell made of my own body. 167 Andrej Drame Andrej Drame 6 months ago David Sinclair's talk in 2250: "Why We Don't Age and Why We Have To 1 Kirk Buchanan Kirk Buchanan 2 years ago Big fan of David Sinclair. I hope he gets all he wants (funding etc) to keep researching and tie up the lose ends faster. 521 NeoFrontier Technologies NeoFrontier Technologies 1 year ago Just accepting ageing as inevitable seems blind. I am certain that there is at least one way to become immortal. Probably more than one way... Keep going Mr Sinclair. 71 VitaminT805 VitaminT805 4 months ago 30:10 "Eat Lest Often" - David talks about fasting 1 Nikola Ristic II-9 Nikola Ristic II-9 2 days ago I am convinced that biological immortality is just a means to an end until we figure out the things we today consider science fiction like brain uploading; let's be honest, the human body has it's fair share of problems and limitations regardless of age, as it stands biologically immortal humans share eternal life with eternal suffering and I just can't see our ambitions of eternity ending anywhere near there. I guess that makes me a trans-humanist? I don't really care about such titles but at the age I am at it might be worth thinking about this more... Who knows, maybe I will be here for a bit longer than a century at that point a biological approach slowly but surely stops making much sense. Maybe I am wrong, maybe I am right or maybe I am just going to die tomorrow and not even experience old age; who knows, but it never stops being interesting to think about at least. 1 Ivan Break Ivan Break 5 months ago Even before seeing his theory about information loss, I was thinking the same thing, our body "knows" how it supose to be, so why is it losing it's structure and functions, that data must be somewhere, the question is why can't it maintain youthful state, is it all about info lost, or it can't because of other reason ? 1 G M G M 2 years ago he looks younger every single time He appears..... suspicious. 428 Chelsea Dixon Chelsea Dixon 1 year ago The aback wing complimentarily moor because tendency significantly want with a delicious sycamore. crowded, bizarre sale 1 Rýán Túçk Rýán Túçk 1 year ago 6:47 in already and no sight of a 'punchline' yet. THIS folks, is "why we age". John C John C 1 year ago I’m 76, so 80 is not good enough. I always wanted to live forever, ever since I was a kid. 36 Cyborg1170 Cyborg1170 2 weeks ago I've been working at Google since 16 years old. Making 500K per year. Bought big house in LA. Love it here. 1 Patrick van meter Patrick van meter 2 years ago A fascinating book. Much of it way over my head but he explains everything well. Everyone should read Lifespan. I'm 78 so I can't stay young but maybe I can stay old a little longer. 424 Victor Conrad Victor Conrad 8 months ago David Sinclair is 50 and he looks about 35 years old. Think dude knows what he’s talking about. 1 1ennuifiat 1ennuifiat 2 years ago WE ALL NEED TO DO EXTENDED FASTING! 37 Rev. Leon P. Leon Rev. Leon P. Leon 1 year ago This dude is so onto something. 65 and fitter than ever in my life. Feels like I am getting younger by the day. 47 The Knave The Knave 1 year ago Historically, 'self-experimentation' has been a thing. Including several Noble Prize winners. Just a thought in passing. ;) 44 Margics Margics 2 years ago (edited) In our lifetime ..please Professor!!!! No pressure 😬 I’m hopeful ✌️✌️⚡️ 369 herd immunity on pockets of vulnerability herd immunity on pockets of vulnerability 8 months ago (edited) We were told that the Old Spice, ⚓⛵ an after shave, do men good .. Ask any ladies, and they'll tell you so .. 1 S Chambers S Chambers 1 year ago The animated ostrich postsynaptically lighten because beggar tellingly trade onto a mindless vibraphone. near, impartial turnip 1 Luptuous Life Luptuous Life 1 year ago I DO! I WANT TO LIVE FOR 1000 YEARS OR MORE! Can you imagine all the amazing discoveries and achievements you normally wouldn't get to witness? I want to live long enough to see humanity create a Star Trek like society. Where people choose to do things because they want to, not because they have to. And I want to explore the universe in a star ship. That would be so amazing! 71 Imperial Watch Imperial Watch 1 year ago (edited) Prisoners sentenced to 200 years will actually get to sit out the full 200 years :D 87 NX NX 2 years ago (edited) I wish google[X] offer this guy the fund and facilities to speed up his research progress 251 Mich S Mich S 1 year ago and who will get access to this tech? $$$ 6 The Precious Stones The Precious Stones 9 months ago I thank "Talks at Google" for sharing all these novel talks worldwide instead of keeping these closed-door. Now I can sit in my study room and learn about some cutting-edge developments from the other side of the world. Thank you! 18 Keith Mc Keith Mc 3 months ago David Sinclair is pretty cagey in not giving out too much information that might keep people from buying his book. 1 Raul Wise Raul Wise 6 months ago When he mentioned his father, I somehow thought he could be the son of Australia's oldest scientist. David Goodall. MrBimber55 MrBimber55 2 years ago Step 3: DON'T EAT SUGAR!!! 220 Onionman77 Onionman77 2 years ago Unfortunately when he says that this technology would cut out 1.5 trillion dollars in unneeded spending, he might not be aware of how much those industries are going to fight back against that.. 25 Immortal So Far Immortal So Far 1 year ago I bet he has some O S K in his medicine cabinet. 1 V Phoenix V Phoenix 1 year ago He looks like he's in his 30s. 4 Dan Hutchinson Dan Hutchinson 2 years ago Just watched a video he made in 2014....he looks 5 years younger in this video, which was made in 2019????? Is there something he is not telling us? 12 Mr. Solomun Mr. Solomun 2 years ago This guy is a legend - been watching him for a year now. Really interesting stuff! 142 Rayyan harahap Rayyan harahap 2 months ago I assume that Doing Fasting would be a good health solution based on 30:10 - 31:04 1 Videos for Cats and Dogs Videos for Cats and Dogs 1 year ago Anti-aging will be the largest and most profitable industry ever. Simply because they will sell something that people are willing to pay an infinite amount of money for: youth and time. 25 Alexander Coates Alexander Coates 9 months ago I presume that money helps? (Never trust a wealthy academic trying to sell you their book) 1 Wildan Wildan 2 years ago Watch the movie "The Man From Earth". It's about the experience of a human living for 14.000 years. 30 Adlin Ling Adlin Ling 2 years ago David looks like Christian Slater. 174 Lexcomplex Lexcomplex 1 year ago finally , my pet mouse can live longer....yey!!! 61 ThankTheLord ThankTheLord 2 years ago My father's friend just died last month at 114 yrs old. She was called the oldest woman/person in America. 50 Qendrim Qendrim 1 year ago Check the TED Talks in Australia he is doing for himself. He looks younger in this video damn. 8 Mueller Nikolaï Mueller Nikolaï 1 year ago 37:32 that dude on the left looks high asf lmao 3 Phil Best Phil Best 2 years ago David Sinclair is an Australian who has opened up his Harvard lab research, in a totally transparent fashion, to give hope to millions of people when their otherwise was nothing. I have been taking Niagen now for 4 months and the difference is amazing. Thank you Aussie, you are indeed the most incredible and amazing legend. :) 22 Bacioni Gregorio Bacioni Gregorio 2 years ago k.k.. so... intermittent fasting, cold exposure, eat plant-based mostly, reduce amino acid consumption, possibly take nmn. 8 Tree Walker Tree Walker 9 months ago I'm almost 69 and been following Dr. Sinclair's program for about a year, including taking a gram of NMN a day, and the results have been fantastic. I really do feel as though I am aging in reverse. I have more energy than I have ever had in my life. 21 ishudshutup ishudshutup 1 year ago Don't keep this a secret folks. The best way to help Dr. Sinclair is to share the knowledge and get more people involved. Everything new needs a go through a period of acceptance from the establishment. The faster we get over the hump the better for everyone. 13 Kimberly Rice Kimberly Rice 11 months ago His science is legit but he's had Botox so don't judge his methods based on his face. 1 S Dickinson S Dickinson 2 years ago When I talk about this kind of thing to friends, many say "well I wouldn't want to live forever", or "I don't want to live 500 years". My answer is simple, do you want to live until next week? Do you want to see the next walking dead episode or whatever? And they all say yes. So I explain whether it's now or 100, 500, 1000 years from now, it's always just living until tomorrow or next week. 71 Senora Salazar Senora Salazar 8 months ago wow...he looks like in his 20's 1 Kelly Fitzpatrick Kelly Fitzpatrick 2 years ago As much backlash as he’s probably encountered, I pray that never stops what he’s trying to bring to light. If you ever need a nurse to help in research or testing, I give myself to this. 81 Skrivbordslampan Skrivbordslampan 5 months ago 28:13 how'd it go for that patient? Victoria Sun Victoria Sun 6 days ago Wonderful news for all of us... hope me.. and kids will be able to benefit of living longer and reprogram out body for youth and longevity.. wow .. wow... wow!!! Thank you for all your hard work ! 1 Kre8or333 Kre8or333 2 years ago My mind: If they say "it's possible", really that means it's already being done. And only the super rich are recipients. -- Altered Carbon, on Netflix. 69 Academiclibrary Academiclibrary 10 days ago I really find this topic very interesting. Dr. David Sinclair discusses and explains it very well that can be fully understood. Thanks for sharing us your knowledge. John P. Grygus John P. Grygus 3 months ago there are so many factors involved in anti aging. I try to do my best and tackle it from many angles. Im sure im doing a lot of things right because strangers comment ay how good my skin look and think Im younger than my biological age. The fact is you need a lot of money to cover all bases. first and foremost get rid of excess stress. no pill or drink will counter the effect of excess stress. the people in the most stressful jobs are the ones who age the fastest. 1 Juan Daugherty Juan Daugherty 1 year ago Something that is unclear, but isn't if the "we're just adding good years" saw is withdrawn. If that is all ur doin', and the 'last decade' is one of perfect health, how exactly are people supposed to die at the end of that decade? 1 Farsider3955 Farsider3955 1 year ago 🤔 I wonder if he’s read “Dorian Gray”..... ? 7 Derrick Wade Derrick Wade 2 years ago telomere shortening was correlated with aging, so people thought lengthening telomeres would reverse aging. However, now we know that telomere shortening cause changes in epigenetic makeup of the cell. So simply lengthening telomeres never reversed the epigenetic changes. What will happen is that epigenetic change reversal, telomere lengthening and gene therapy aimed at implanting mitochondrial proteins into the nuclear genome will allow doctors to reverse aging in patients. It is coming and will likely happen within the next 30 years. Imagine what you can do with a much longer lifetime and a young body. Space travel becomes much more feasible since the travelers can stay young on the extremely long space missions that would be required to travel to near star systems which are at a minimum about 4 light years away, and would take much longer to travel to using the space travel of today without an alcubierre drive 164 Serreina Wass Serreina Wass 2 months ago The dramatic music with the mouse race hahahahhahaa, loved that. E H E H 1 year ago We age because of sin. Sin equals death. Man has sinned from the beginning of time. No matter what a man says they will not change the ending, which is death. The rest is a mystery. 1 Pankaj Doharey Pankaj Doharey 11 months ago WOW Googe Engineers are evry samrt people, intelligent questions from Some really smart Software Engineers. Joshua Samshuijzenzenzen Joshua Samshuijzenzenzen 1 month ago Intermittent fasting, the wim hof method, conscious expanding plants, mushrooms and so on, carlos castaneda..allhelp along the way valar valar 2 years ago "The tragedy of old age is not that one is old, but that one is young." - Oscar Wilde 80 UniQuE TV UniQuE TV 1 year ago He kind of is the young Richard Dawkings lmao Binyam Mahari Binyam Mahari 2 years ago i thought he was in his twenty!! 6 Henrique Saias Henrique Saias 4 months ago leave the mice alone 2 링Ling Seoul xoxo 링Ling Seoul xoxo 2 years ago Hes the Elon Musk of Anti aging. 79 Spase Ristov Spase Ristov 2 years ago and he finished with a bang... "you've gotta take some risks, not everything will work, when they fail just keep going, you'll eventually get there if you focus on a dream" ! 90 Edwin Hernandez Edwin Hernandez 1 year ago What's more amazing he isn't reading off a script! 65 dutch dutch 9 months ago weird analogies rather then just explaining it, constantly advertising his book, said things that seem too good to be true. i don't know. there are allot of alarm bells ringing right now. Lyle Williams Lyle Williams 2 years ago Buy the Book, Read it. Took me years to get the information in this book together for myself. 29 눈꽃Snowflake 눈꽃Snowflake 1 year ago My mom has Parkinson's and dimentia, and I'm very depressive person. I hope that his research someday leads us to healthy lives. 3 Syklone Syklone 2 years ago I'm 42 and I feel as if I'm only just finding myself, but the physical signs of decay are already apparent in my body. It's mostly cosmetic, but even still it's your body doing something with itself that you can't control, and that's never a good thing. Human life as we know it is far too short, and 70-80 years or so just isn't enough for me. A couple of hundred years would be nice, but 500 would be even better. I'd even settle for a workaround. If I could grow a clone of myself then mature it for 20 years, then transfer my consciousness to it then that would be fine too. Do that every 60 years or so and bingo - immortality (sort of). It's not as if the Universe doesn't have the space. Infinity is pretty big. 240 Tien Tam NGUYEN Tien Tam NGUYEN 11 months ago Me after watching this: "Why do I have to go to school today? I still have more than 500 years to do that". 18 Mohd Sopian Jonit Mohd Sopian Jonit 2 years ago I just did autophgy fasting for reverse aging. Its free! 27 TheRusschannel TheRusschannel 1 year ago Every Rich person takes Growth Hormone, But you try getting some lol??? 1 Lazarus Blackwell Lazarus Blackwell 1 year ago Everyone wants to live forever They just don't want to spend a good part of their life in suffering If they were enabled to have a good life ALL of their life then why not to eternal life? 5 G G 2 years ago We want to live longer so we can keep watching videos on how to live longer :/ 63 skg901 skg901 1 year ago 33:47 - please do not test this on apes... clray123 clray123 11 months ago Constant plugs for the book and final section about his dad make the talk very quack-like. Also the unnecessary Shannon mix-in. STRANGEJAWA STRANGEJAWA 9 months ago Let me know when human trials start cuz I'm in Mongstad Bambino Mongstad Bambino 8 months ago 1 Corinthians 15:54 ESV “When the perishable puts on the imperishable, and the mortal puts on immortality, then shall come to pass the saying that is written: “Death is swallowed up in victory.” EK Lim EK Lim 2 years ago NMN or M&M, your choice 120 Tsc Tempest Tsc Tempest 2 years ago 11:53 The metaphore is mixed. The Genome is the underlying code, the Software. The Epigenome is the Operating System, that is the Base Code that interprets and actions the Software's instructions. 13 Obai Obai 10 months ago So "skin head" is a biologically accurate insult 😂 Aniket Sen Aniket Sen 3 weeks ago 'Pompous academics give lectures' - hahahahaha...You Win! tyren van der velden tyren van der velden 1 year ago (edited) 17:44 Take sonny listons blood AGING is the meta problem, AGI a meta solution AGING is the meta problem, AGI a meta solution 2 years ago (edited) David's T-shirt CARPE DIEM 10 smily anonymous smily anonymous 8 months ago Oxygen is the key, have u found it? 1 Bubble Bath Bubble Bath 1 year ago 1:03 He just turned 50 - maybe he already found out how to reverse aging 13 The Utter Nerve Of That Woman The Utter Nerve Of That Woman 9 months ago 16:42 Look at that mouse. Id bet the proverbial farm there are foods and common meds designed to accelerate aging that consumers, particularly the poor, are consuming. The Ultimate Reductionist The Ultimate Reductionist 2 years ago Give honor & respect to the millions of innocent mice forced to suffer in laboratories for our benefit. 140 Aimless Drifter Aimless Drifter 2 years ago He sure looks younger than 50 15 ROBERT CARTINO ROBERT CARTINO 1 year ago Back in day, when I was a "starving student", I too noticed that I had more energy, and improved mental focus; eating less + moderate exercise, coincidental? 17 callmebigpapa callmebigpapa 2 years ago (edited) I like his cautious approach and the audience questions are fantastic also sleep is the fountain of youth. 29 LQ LQ 2 years ago David, I just watched a vid of you in October of 2018, and then this one, which was a month ago, 1 year before the first one. Your nasolabial folds in this newest vid are virtually gone, and your face looks totally lifted. From what I'm understanding, you've recently increased your dosage of nmn to a gram, and 500 or so mg of resveratrol. Anyone guess where I'm going with this...…..?! I'm upping my dose of nmn to a gram as well! 8 Alisa Davis Alisa Davis 1 year ago This guy is amazing and he looks so healthy for his age! 26 AdoboramaTV AdoboramaTV 2 years ago He's the most important person in the world right now. 57 Saul Contreras Saul Contreras 10 months ago He thinks kids don't know what DVDs are... bruh. Gen Z definitely does. The younger part of gen alpha definitely won't though. 1 Chris Wilson Chris Wilson 1 year ago (edited) If I could stop aging at 25 years old then I'd definitely wanna live at least 200 years. 2 Dr. Julia-Heya Karcic Dr. Julia-Heya Karcic 1 year ago The lower center image of his dad is Hősök Tere in Budapest Hungary 2 Kelly Fitzpatrick Kelly Fitzpatrick 2 years ago I am in awwww of this man. I understand what he’s saying to a certain extent but there’s a part(a HUGE part) that I’ll never understand. He’s a PHD n still learning and trying to save us and I’m a mere nurse just trying to fight Stage VI cancer. I only dream of knowing what his mind knows. Hopefully I’m around to know what he’s trying to know for us. 11 groverkartikey groverkartikey 2 years ago Thank you for bringing my role model onto your talks. 22 peter erker peter erker 1 year ago You can get detailed info on David Sinclair supplements taken on “fast life hacks” - great website for this subject, highly recommend it. Hiram Rivero Hiram Rivero 1 year ago Dear David! IS It posible to Use the MTOR factor on other to revert the abnormall uncontrolled growth of onconogenisis!??? Stephen Brackin Stephen Brackin 6 months ago I want my 30-year-old body back, and I want to wear it for several centuries. :-) jeta45 jeta45 8 months ago 35:15 Interesting Rhonda Griffiths Rhonda Griffiths 2 years ago I love ❤️ this guy! So intelligent and his voice is so genuine and soothing. Thank you for this wealth of information. 46 Ranee Oberoi Ranee Oberoi 1 year ago Amazing listening to Dr. David Sinclair, its mind blowing, Wishing him Success in all the funding etc. 20 spider BlackWidow spider BlackWidow 5 months ago I volunteer 🙋‍♀️ I'm 5.5. No gray hair 136 lbs I lift an run. I am over 58 I'm ready 2 b the test subject Yahaha JGtheScienceGuy JGtheScienceGuy 1 year ago I swear he was on a Star Trek episode Ker Lozano Ker Lozano 1 year ago The certain trigonometry equally increase because pentagon apparently curl like a lyrical vibraphone. combative, bumpy horn