Do we finally have control over ageing? | Prof David Sinclair

#HealthyLongevity #webinar #NUSMedicine​​​​​ NUS Medicine 8.87K subscribers Ageing is inevitable, but what if everything we've come to believe about ageing is wrong and we're able to choose our lifespans? What if ageing is a 𝑡𝑟𝑒𝑎𝑡𝑎𝑏𝑙𝑒 disease? In this week's #HealthyLongevity #webinar, Prof David Sinclair from Harvard Medical School shares a bold new theory for why we age. Prof Sinclair is also the author of "Lifespan, Why We Age – and Why We Don’t Have To" (https://lifespanbook.com/ ). Register for upcoming webinar​​ sessions at https://nus-sg.zoom.us/webinar/regist... #NUSMedicine​​​​​ #webinarseries​​​​​ --- References: - Closing video source: https://www.youtube.com/watch?v=vIFEp... Disclaimer: The opinions and advice expressed in this webinar are those of the speakers and do not represent the views and opinions of the organizers and National University of Singapore or any of its subsidiaries or affiliates. The information provided in this webinar is for general information purposes only as part of a general discussion on public health. The information is not intended to be a substitute for professional medical advice, diagnoses or treatment; and cannot be relied on in place of consultation with your licensed healthcare provider. All Rights Reserved. All of the proceedings of this webinar, including the presentation of scientific papers, are intended for limited publication only, and all property rights in the material presented, including common-law copyright, are expressly reserved to the speaker or NUS. No statement or presentation made is to be regarded as dedicated to the public domain. Any sound reproduction, transcript or other use of the material presented at this course without the permission of the speaker or NUS is prohibited to the full extent of common-law copyright in such material. 429 Comments rongmaw lin Add a comment... Lucrezia Dippolito Lucrezia Dippolito 6 months ago My mom is 98 and she has glaucoma. Her mental state is good except for a little memory loss. I wish she could be part of your trials for sight improvement. This would be a miracle for her🙏 52 Natty Dred Natty Dred 7 months ago (edited) Longevity Rockstars. Straight up science, no click bait. No toxic doom peddling, or impossible promises. An upbeat message with suggestions for action at the end of each show. It's hard to believe this channel exists. Thank you! 31 The Sheekey Science Show The Sheekey Science Show 7 months ago Really great conversation addressing some important questions in the field! 83 Earla Weese Earla Weese 6 months ago (edited) Thank you so much, Dr. David Sinclair for all of your work and research. You and your team are truly a blessing for the human race. Thank you to all of the scientists and researchers currently working on life extension and longevity. 10 Nguyễn Thị Bích Ngà Nguyễn Thị Bích Ngà 7 months ago (edited) Extremely thanks to Professor Brian and Professor David for sharing. You are the legends. Can't wait for the next show to learn more about reprograming. 34 250txc 250txc 6 months ago Both these guys come across very well and with NO hidden agendas ... Good luck on your research. I'm 63 and feel great after cutting sugars\CARBS as low as possible AND eating only twice aday usually; going another ~20 yrs might be possible so I'm hoping for a breakthrough from you guys. 19 Aaliyah Lee Aaliyah Lee 8 days ago I have been watching Dr. Sinclair. His book is also very educative. I love that book. In there, there's no point increasing lifespan without health span. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. I hate aging and the illnesses it brings over time. This is why I am now taking NMN supplement by Vitruvin constantly. Brent Nally Brent Nally 7 months ago Two longevity legends in one epic video! Bravo! 67 Rapamycin News Rapamycin News 4 months ago Great to see the progress at NUS, and also in David's lab. The reprogramming efforts are really interesting - but my concern is that it may be decades before it gets translated to the clinic, and will be expensive if it turns into a therapy. Perhaps Altos Labs can speed things up. I think the NUS efforts at identifying supplements and drugs that are most helpful in aging are the big win for the next 5 years - drugs like rapamycin. V. Hoppen V. Hoppen 3 months ago Thank you @Dr.Sinclair for all your work. I used to get so frustrated when medical professionals would tell my father, you're getting older so we aren't going to treat Xyz... made no sense to me. you are proving we all deserve treatment regardless of age Dan Dan 7 months ago happy to see more of David and reverse-aging research 31 The Macso The Macso 5 months ago Can we please fund this man with everything he needs? 4 Gonzalo De La Maza Mendizabal Gonzalo De La Maza Mendizabal 6 months ago This is such an interesting topi! I am curious, I understand that theoretically we can use many different interventions to tackle all the hallmarks of aging, from telomerace to increase telemeters, Partial reprogramming to improve mitochondrial health and restore epigenetic youthful patters as well as the use of different proteins to remove wastes. But genetic instability seems impossible to treat. Correct me if I am wrong. I hope that accumulated mutations don't have much of a damage them self, rather its just when they occur that they affect other parts of the ageing process. 2 Diana Dalo Diana Dalo 7 months ago HRT and DHEA etc for menopausal women is a huge longevity question and it would be great if it was addressed....seems quite important since it regards 50% of the population 18 Irish Willow Irish Willow 6 months ago Not sure if David's theory will reverse or slow down aging but the supplement he recommends sure give energy to my aging years. Much better than not having the energy to get out and enjoy. 16 Hacking The Human Time Machine Hacking The Human Time Machine 7 months ago Wonderful presentation, thanks! Can we expect one day to be able to read a paper on your results in primates?? 5 Nils from Alaska Nils from Alaska 7 months ago Excellent video - thanks for posting 4 Archanjel Michael Archanjel Michael 5 months ago I read his books about intermittent fasting..and resveratrol...I learn lot from him, and im very grateful ..... his studies are very interesting... .. . My grandfather reach age 96 and he practised intermittent fasting...i do believe that healthy lifestyle can impact immune system and general health ...organic superfoods, exercise and positive mindset are great way how to live longer and more healthy.... 3 Long Vu Hoang Long Vu Hoang 6 months ago Thanks Prof. David very much. 3 DrArvind Poswal DrArvind Poswal 6 months ago Very informative 👍 1 samantha porter samantha porter 4 months ago This man is a genius! ki5ngau ki5ngau 4 months ago Two of the smartest persons giving free advices on anti-aging, nice. mateen haq mateen haq 6 months ago Hi, Sir David is there any breakthrough in the treatment of M.D involving neuro cells? 1 Irene Hwang Irene Hwang 5 months ago A fascinating idea, 80 or 90 years is the most extended life for people. We hope just facing death in proper condition, healthy body, happy life, not a life for a much longer time. Intermittent fasting and taking astaxanthin is the way I'm doing it. Lina AbouDheir Lina AbouDheir 6 months ago Loved it Soooo much learning Thaaaaank you 1 amber skies amber skies 21 hours ago Everybody wants to remain as independent as possible in old age, no? Muscle mass decreases with advanced age resulting in weakness and balance/coordination issues. The ways to combat this decline is to work out and keep as much muscle on one’s frame as possible. Give NMN supplement a shot and see if it works for you coz what works for one person might not work for the next. In my opinion, I am satisfied of taking NMN by Vitruvin Nutrition along with my work outs, walking kms, and yoga... Lucrezia Dippolito Lucrezia Dippolito 6 months ago I have been taking NR for 2 years now and I look and have the energy of a 30 year old. I’m 64. I exercise, fast and vegetables 90% of my diet. I’m waiting to purchase Dr Sinclair’s biological age testing kit. Where can I get one in Canada? 1 mark veen mark veen 7 months ago (edited) Seen people age 50-60, looking and acting like 30 years old. With perfect skin and wrinkle free. Doing 0 supplements, fasting, superfoods or any other so called health practises. They are just in tune with their body and live joyfully. Having good genetics helps alot also. Your own intuition can be your best tool. What to eat and when to eat. Most people are not in tune with their body's circadian rhythms, however. Also seen people age 40 doing all kinds of supplements, fasting and exercise for decades. But they seem to have aged terribly. So untill we see 60 year olds looking and acting like 20. Nothing incredible special is going on. It's 2021 and I think we're just started to grasp the basic understanding how aging works. it's incredibly complex. In this timeline your best bet is probably living as naturally and in tune with nature as you can. Looking at the blue zones. The real paradigm shifts are probably still a few centuries away. 16 Shelley Swyer Shelley Swyer 6 months ago (edited) This is awesome. I want to know how at 51 David doesn’t have a single grey hair with a biological age of 34.1 I think he said. 5 Ali Alabdulal Ali Alabdulal 6 months ago I wish Dr David discuss several concerns on NMN and Resver been raised and discussed by other specialist in the field and published on Youtube so one can feel ok taking these supplements with confidence 7 Yayang Tapir Yayang Tapir 4 months ago (edited) A big bonus from science to human kind - Dr Sinclair. I'm curious what he is drinking right now , it's not wine for sure!☺️ Patricia Búdová Patricia Búdová 6 months ago Prof Sinclair is really getting younger 😮 He looked different/older in Tom Bilyeu show two years ago 🤔Or is it some kind of screen-filter?…If not, the difference is amazing 7 J Andersen J Andersen 6 months ago Great video! norhaina lidjamansali norhaina lidjamansali 6 months ago hi thank you for a great show what is the effect of vit d and vitamin c in aging. Liran Gaston Liran Gaston 7 months ago TOP LEVEL OF HUMANITY 7 Gg Fla Gg Fla 6 months ago Can you talk about NMN causing more inflammation thus being harmful rather than beneficial. 2 bigblockjalopy bigblockjalopy 6 months ago Lots of people with a medical background critizising Sinclair, however they look their age or older. Sinclair looks 20+ years younger than he is. Guess who (as a layman) I am trusting. Besides, what he says sounds plausible. 14 Chrono Chrono 6 months ago Time is not toxic, bad habits are. 5 Brylan Jacobs Brylan Jacobs 1 month ago I have to measure the anti-aging effect of a protein in human cell lines. I want to use epigenetics as a marker for aging, alongside senescent markers. Will the differences in methylation frequency of cells in particular parts of the cell cycle and senescence correlate to the reversal of the aging process after treatment. Anamul Islam Anamul Islam 6 months ago Some say resveratrol is not good and actually interrupts the cellular process. could you advise? 4 aymeric B aymeric B 5 months ago Would be nice to have the time steps :) FireFacts FireFacts 4 months ago (edited) With the current rate of life span expectancy increase in 60 years from now the average lifespan will be between 93 and 99 years. Meaning that about half the 30 year old's of today will live to be over 100 years old. And that is not taking in to account things like the benefits of intermittent fasting, Gene therapy, NmN, bio-printing and so on. Kenneth Marquis Kenneth Marquis 6 months ago Sleep, less stress, exercise, proper diet and nmn resveratrol is keeping Sinclair young. Try it 4 Roger Isaksson Roger Isaksson 4 months ago I’d like to live until: 1. The inevitable fatal accident happens 2. Until I’m bored of being a human being with limitations 1 Bobby Miller Bobby Miller 6 months ago It’s great to slow down the aging process. They should look into how to eradicate HPV virus in humans and all other Virus. 1 MarcoGee MarcoGee 6 months ago Could quantum computing accelerate the progress of ageing ? 3 Cal L Cal L 6 months ago I'd like seeing a scientific study on the difference in people born on different seasons, like summer,winter, spring and fall and how it affects them in adulthood. 1 Lair Heron Lair Heron 5 months ago We'll have to solve our short life spans if we ever want to explore the cosmos. Vestu Vestu 2 months ago Sinclair does look ridiculously young for someone who's 52 :D 1 Bloke About Town Bloke About Town 7 months ago That 92 year old man at the end of the video, wow! Bring him on the show for an interview. 7 Addie Frahm Addie Frahm 4 months ago I would like to order NMN..Resveratrol..I’m having a very difficult time finding a product that is what it says it should be. Can someone please please recommend some brands for both these items. There’s so much on Amazon there’s so much everywhere a person feels overwhelmed and I just don’t wanna order something that would create a problem instead of solving a problem N1mBUS Music N1mBUS Music 5 months ago ashwaganda is a spectacular herb that lowers blood sugar as well. it seems sugar is the enemy 2 Steven Lucks Steven Lucks 6 months ago I take NMN and Trans-resveratrol and 100 grams of pre-biotics - I took the UCLA test and my biologic test age is 63 and by candle I am 70. I took the microbiome test and I have no low grade inflammation. 4 A P A P 7 months ago I would say the biggest payback is from banning seed oils. It could easily add 20-30 healthy years. 4 Aztec Warrior Aztec Warrior 4 months ago (edited) Does anyone noticed that David looks younger than he did 2 years ago. I’m not even joking . Aging Backwards Photo Evidence of Aging Reversal Aging Backwards Photo Evidence of Aging Reversal 5 months ago Practice and theory is very different RILEY (SlotDog) PLAYS SLOTS (He's a dog) RILEY (SlotDog) PLAYS SLOTS (He's a dog) 3 months ago (edited) These guys are talking about wanting to live longer . It seems like I'm living forever . I've been alive for as long as I can remember. My goal to keep living forever. So far my goal is 100% successful. Have not died even once. So far so good . I've been around for 65 years and haven't done anything. But I've achieved my goal . Time to eat cake and light some candles Jo Wong Jo Wong 3 months ago fantastic John Marrs John Marrs 5 months ago Should combine Sinclair’s techniques with the Israeli hyperbaric oxygen therapy that lengthens telomeres. That might be the holy grail. 1 Billy Hanafy Billy Hanafy 6 months ago Anyone knows what drink that Dr. Sinclair was drinking? It looks like a breakfast replacement. Thanks. 3 Angelica Camargo Angelica Camargo 6 months ago Do you guys know where to find information in regards to “eating less”. It is mentioned by many doctors but I don’t think I have heard what exactly does that mean in regards to calories. In the video is around min 9:30 UHFStation1 UHFStation1 2 months ago I hope spinal bones can remodel more correctly. No more spurs or stenosis crushing our nerves. Lynn D Lynn D 7 months ago Possibly reverse blindness starting in a year 😳 6 Donna Houston Donna Houston 6 months ago Does anyone know the molecules that’s being used to reverse Blindness in mice? Corteum9000 Corteum9000 7 months ago So what's something that people can take right now to help with aging? NAD+? 12 Reflect Reflect 6 months ago These two professors have got a 2 years age difference, yet when you look at them this gap is evidently larger. I bet Prof Sinclair is already applying his knowledge on himself (with a little bit of botox I would say hahah)! He looks great! :-) 1 Choco S Choco S 6 months ago Sinclair looks like he got younger :O he's also acting a bit differently from how he normally does on other podcasts. 3 SleepSmartSmashStress8 SleepSmartSmashStress8 6 months ago Ageing is inevitable 1 Juj Juj Juj Juj 6 months ago Someone give Sinclair some coffee stat...lol 1 Heyyy bill gates windows Heyyy bill gates windows 7 months ago whats ur take on nanotechnology any thing in there we could use to extend the lifedspan that way??? 7 Deeds777 Deeds777 6 months ago Its a specific protein in new blood plasma infusion by decreasing aging on a level faster then any other research known. Blood will eventually be very expensive. 1 Skippy Skippy 6 months ago The area of science I would cheer and celebrate is when we no longer use and abuse animals. フᎶフشپんフキん𐡀んフ冰𐡀ん徐冰𐡀んキフんپشフᎶフ フᎶフشپんフキん𐡀んフ冰𐡀ん徐冰𐡀んキフんپشフᎶフ 4 months ago Do we finally have control over ageing? No, we don't. 1 samuel vance samuel vance 5 months ago Biden needs to sign an Infrastructure Bill for the human body. If this guy had a Billion Dollar$ to do research with, that would pay for a bunch of labs, and lot mice. lucinda Williams lucinda Williams 6 months ago The powerful and evil people controlling the world will have this first! Midas Snap Midas Snap 6 months ago David continues to get slightly older looking each year. When he starts looking younger I'll know they have figured out something. 8 Nieczerwony Nieczerwony 4 months ago Extend your life to spend it in Megaverse for Mark Z.😉 Valerie Stark Valerie Stark 6 months ago i wish i could believe id have access to this, but i just don't think i will. i only make 27k a year and i work for a pharmaceutical company 2 x tian x tian 4 months ago Funny to see Mr Sinclair going down heavy with the filter.... Jamil Aad Jamil Aad 7 months ago (edited) Sign me in your NMN experiment 👍 Dr. Sinclair 1 Ned Ned 7 months ago Graph from start of David's presentation: if that his goal, it all a waste of time and money. It's as if Elon Must started SpaceX to go across town. We need a program of robust rejuvenation, along the lines of SENS. 1 Heyyy bill gates windows Heyyy bill gates windows 7 months ago nah the real problem is the telomerase length which if their is a way to manipulate it then u can live indefintely <3 2 Kage1128 Kage1128 6 months ago 2060 really? I guess Sinclair doesn't believe in the technological singularity 5 esrA eloH esrA eloH 6 months ago Haaaa check Dvid so casually drinking his coffee from an actual jug that's cool 1 Patson Lim Patson Lim 5 months ago i don't know sometimes treatable or not cannot be rationalize by logic when you love someone David Lloyd-Jones David Lloyd-Jones 6 months ago I don't want a test on my mouse. I want a test on me. Just hold that "sacrifice" bit, though, OK? I get queasy about subjects' heads getting chopped off, even when it's mine. 1 Jim Sigrist Jim Sigrist 3 months ago (edited) Dude, seriously? Ever calculate the socioeconomic consequences? Raise the retirement age to 80? 90? Longevity requires a complete paradigm shift. Who wants to do a shitty job for 60-70 years? How long will workers want to pay for all those living to 150 in 70 years retirement? Is science ahead of it's skis? Someone needs to put equal effort into longevity consequences. We are already living in population overshoot. All things must be considered with revolutionary change. Cathy Kirton 6 months ago Metformin won’t be given by doctors for longevity in South Africa 🤷‍♀️ 1 neil thompson 7 months ago Just stories and salesmanship. Some interesting theories. But it is not advisable to experiment with NAD boosters. If you have cancer in your body, i'm sure it will love it too. Also senescent cells, he tells one side of a complex story. The other side is they actually have a very important function (who would of thought). To keep cancer under control, in a dormant state. Listen to this guy as a young person, you are probably more likely to have an aggressive cancer. 5 Jon AustinTexas 6 months ago If you don’t “do something” by the time one or more pathways are validated it’ll be too late: i 청ずらたん 7 months ago I greatly admire this endeavour, but I think it will not be possible to succeed in humans ultimately. It won't be allowed that we cure this. John Curtis 6 months ago (edited) I do not wish to appear critical but many long for immorality who do not know what to do with a rainy Sunday afternoon. So my advice is simple. Do not seek so strenuously to push your lifespan. Health, absolutely. Keep to habits that keep infirmity at bay. And always adhere to the one maxim I follow; use it or lose it. But lifespan? That's a fools errand. Seek, rather, to use the time which you are given wisely and maximally to the benefit not just of yourself, but to all those you love and for whom you care. And when the time comes exit as gracefully as you can, and move on to that which comes next. In so doing remember there is no need to be fearful about this. Because consider that you are manifest energy and so long as Time exists energy is never destroyed, it merely transforms. So wherever it is we go next after this span of time, however it is we are transformed, I wish you well with it. John~ American Net'Zen Lydia Leung 3 months ago There are comments that NMN promotes cancer. I am getting a bit worried cause I am taking NMN. Pls advise. Tks Freedom is Healthy 7 months ago Was very surprised to hear Sinclair got the covid jabs, he of all people should have been able to measure how many years the vaccines took off his life. There'd be an increase in inflammatory markers, for a start. 3 danwarb1 6 months ago No. Life expectancy is declining in the US and UK as the national social infrastructure built post WW2 is corrupted and sold off. 3 Karl Gruen 6 months ago Not enough studies on humans. We are not mice nor yeast. Eating less often is so far not conclusively proven to lengthen life expectancy in humans, neither caloric restriction. 1 Pure Strength 7 months ago The best way to live longer is to live a strict Seventh-day Adventist's lifestyle observing the 8 laws of health plus the supplements. Remember that according to the Bible life extension comes from the tree of life. Man was never created immortal but could. So what we eat does really matter. 2 EMMA LUCIA EV 7 months ago Same info he has been giving in every interview Respectfully I would rather have JLO advice on aging than from this smart PhD s. 😞 6 Long Vu Hoang 5 months ago Mr. David of Bible. A greatest King of God. God is King of all Kings. Dan Mosby 7 months ago (edited) what about olive oil??? 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