David Sinclair | PRETTY INTENSE PODCAST EP. 48

Danica Patrick 133K subscribers Today on the Pretty Intense Podcast we are excited to be talking to the highly acclaimed, Dr. David Sinclair, professor of genetics at Harvard Medical School, Dr. Sinclair is going amaze you, with what science has in store for us. He tells us about what they know they can do already, and what that proves they will be able to do in the future. We hope you enjoy this truely mind blowing episode. Click here to watch more episodes of the Pretty Intense Podcast: http://www.danicapatrick.com/podcasts ==== Dr. David Sinclair, professor of genetics at Harvard Medical School, has been leading the way in his research on aging and longevity mechanisms. Dr. Sinclair is the founding director of the Paul F. Glenn Laboratories, for the Biological Mechanisms of Aging at Harvard. In 2004, Sinclair, along with Andrew Perlman, Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, founded Sirtris Pharmaceuticals. Sirtris was focused on developing Sinclair's research into activators of sirtuins, work that began in the Guarente lab. The company was specifically focused on resveratrol formulations and derivatives as activators of the SIRT1 enzyme; Sinclair became known for making statements about resveratrol like: “(It's) as close to a miraculous molecule as you can find.... One hundred years from now, people will maybe be taking these molecules on a daily basis to prevent heart disease, stroke, and cancer. In 2011, Sinclair was also a co-founder of CohBar, along with Nir Barzilai and other colleagues. CoBar aimed to discover and develop novel peptides derived from mitochondria. In 2018, Sinclair was made an Officer of the Order of Australia (AO) for "distinguished service to medical research into the biology of ageing and lifespan extension, as a geneticist and academic, to biosecurity initiatives, and as an advocate for the study of science". Dr. David Sinclair has also authored 4 books: Lifespan: Why We Age – and Why We Don't Have To, How to Start an Evolution, Just In Time: The Discovery of Sirtuin and How it Will Change Everything, David's Wow - David Sinclair. Check out our other videos: Aaron Rodgers | FULL VIDEO PODCAST https://www.youtube.com/watch?v=RByn8... Michael Strahan | FULL VIDEO PODCAST https://www.youtube.com/watch?v=0Qb6C... Joe Manganiello | FULL VIDEO PODCAST https://www.youtube.com/watch?v=Z3No9... Checkout this playlist: https://www.youtube.com/watch?v=Ijgk-... Subscribe to our channel: https://www.youtube.com/user/danicapa... 375 Comments rongmaw lin Add a comment... Karen Andrea Brown Karen Andrea Brown 1 year ago Been taking NMN and trans-resveratrol and my glucose response has improved, I don't get an afternoon crash, my deep sleep and rem sleep increased, some of my grey hair strands have turned brown again at the roots. Also, my eczema under my eyes went away. Thanks Dr. David Sinclair! 17 Jeff V Jeff V 1 year ago Excellent interview, thank you. I have watched multiple interviews with Dr. Sinclair, and most were done by experts in science and of course genetics. This interview demonstrated the benefits of an exchange between a non-expert and Dr. Sinclair. There were many examples, but one is that Ms. Patrick often asked him to clarify certain comments and define some medical terms which makes the interview more comprehensible for laymen. In an expert-to-expert interview, the two people involved often forget their audience hasn't yet achieved a PhD in genetics! 34 Phoenix Kepo Phoenix Kepo 1 year ago Loved the interview. Thank you for sharing Dr D Patrick. 5 Zach Uttke Zach Uttke 1 year ago Thank you for doing this! Super interesting conversation 14 Ponte Vedra Ponte Vedra 1 year ago Dr. SINCLAIR MUCH RESPECT TO YOU SIR. 10 Colin Morris Colin Morris 1 year ago Well done loved the way you were able to extract simple analogies question though is or has anyone extracted DNA from umbilical cords and transferred back to same mouse when it ages to see effects 1 Darren M Edmonds Darren M Edmonds 1 year ago Liked the laid back interview, drew out plenty of information. 14 CG G CG G 9 months ago Danica did fine... This is an interview... Asking questions is how it begins and I didn't find her rude, she let her guest speak. This was fascinating. Thank you. Progress NotPerfection Progress NotPerfection 1 year ago Danicka your amazing for bring a great guest but also being an awesome interviewer! Perfect 👌 interview 7 Brian Heffernan Brian Heffernan 1 year ago I just found your podcast, Danica. It was really enjoyable. Greetings from Columbus, Ohio. 4 Al G Al G 1 year ago I am very impressed with Dr. David Sinclair!! Amazing man! Live healthy and youthful oh ya! Thank you for being an excellent teacher to explain the incredible science you are working on. You are helping humanity and I thank you. 2 Max Meier Max Meier 1 year ago That fact that he does actually look like he could be 35 at 50 definitely doesn't hurt his credibility 60 Kyle Paxton Kyle Paxton 1 year ago Danica going into podcasting with a strategy. I like it. 2 James Craig James Craig 1 year ago Thank you for bringing up longevity! 1 Rose BW Rose BW 8 months ago Thank you for sharing your genius with this world thank you thank you thank you D Marie333 D Marie333 7 months ago My nana lived completely healthy to 113yrs, she was so adorable! She gardened, cooked, cleaned, went up and down stairs to and from her room, she cooked, cleaned, ate all things Italian, bread, pasta, meatballs etc, lived with her two sisters (who both smoked indoors + her husband did also while he was alive) She told me that it hurts to be that old before she left, but no medicine, only one advil a day, coffee, water, and occasional/often glass of red wine! We are in the gueniss book as her grandchildren! I used to eat steak often without a 2nd thought on ethics of it, untill I began having dreams from the pov of a cow, VERY traumatic dreams where in various heart wrenching scenarios, i would wake up in tears, sobbing, emotionally wrecked, like having my calfs ripped away from me, my friends i loved deeply swept away, helpless with hooves not hands, locked behind a fence, somehow intuitively i came to understand that the dna of these cows i had ingested, entering my being in a way that made their trauma a part of me... I've never eaten or craved eating any kind of dead animal flesh since this, also never had a nightmare like that again .... 1 Ray Nabozny Ray Nabozny 1 year ago (edited) Danica I'm a Ford guy and have been to car races all over the world and raced a shifter kart for over 20 years but watching you lead the field at the Daytona 500 in 2013 was one of my greatest race car fan experiences. Second only to being at Monza Italy in 1996 when Michael Schumacher WON the Italian Grand Prix for Ferrari. The two of you must be the most physically fit drivers of all time. You look happy and I'm happy for you,from Ray in Michigan rhyfelur rhyfelur 10 months ago Ignore the haters. If you sat any one of them down with Dr Sinclair, they would probably turn into babbling idiots. You asked good questions and were nicely composed. Also, Dr Sinclair appeared to genuinely enjoy having a normal, unpretentious conversation. 1 Egg Mendy Egg Mendy 1 year ago So happy to see this guest! 4 Jason Sebring Jason Sebring 1 year ago I've watched all of David's videos and its pretty obvious he hasn't smiled more. :) 14 Vic O Vic O 1 year ago Great questions, keep it up! 2 Sheridan Twice Sheridan Twice 4 months ago David is outstanding! The way that he wants people live longer but healthy is excellent because we can enjoy our live and our loves one. Thank you for your amazing job. God Bless you! M. M. 1 year ago I saw David’s interview from 6 years ago, he definitely looks younger and healthier 30 Summer2022 California Summer2022 California 1 year ago David Sinclair is great!😊 3 Christine Curteis Christine Curteis 1 year ago Thankyou David, loved your book, I get all my products from Eternum labs in Australia... 2 Progressive ideologies Progressive ideologies 1 year ago (edited) #Davidsinclair should do solo programme, not interrupted by any one🙏🙏 7 Ruot Boun Ruot Boun 8 months ago I appreciate his research. Progress NotPerfection Progress NotPerfection 1 year ago 2nd time watching this in full. Amazed at how well of an intervwer that woman is and also how genuine and helpful the scientist is to just share his research for well being. Im a huge fan of this woman smh. She's beautiful 10 ahdaf naik ahdaf naik 1 year ago amazing podcast <3 4 Talia Rappatone Talia Rappatone 1 year ago Fascinating!!! Curious about reversing eye damaged due to shingles? Not natural aging but actual damage due to a virus? 3 My NMN Experiment My NMN Experiment 1 year ago You have to respect any scientist who actually tells you what they are doing. 1 Bu Jin Bu Jin 8 months ago 1:18:20. I've read and watched a lot of Sinclair's stuff, and it's really difficult to get a handle on where you should get the items he discusses. (Trans Resveratrol, NMN, and Metformin.) The problem is you really can't trust must of the supplements you see being sold. (Are they pure and high quality?) Even if the company is reputable, if you buy the stuff through a reseller like Amazon, you don't know how long it has been sitting on the shelf, and molecules like NMN are not stable at room temperature. Which is to say nothing of how hot they get if you are shipping them during the summer. Basically, you need to keep these things refrigerated or in the freezer, and I think it would probably be best to buy them when it's cool if not cold outside, in order to preserve them in transit. So stock up on the whole year's supply in the cooler months. This is especially important for NMN, as if it degrades, it'll do the exact opposite of what you want it to do. Based off of the info Sinclair gives here, that you want an established company, which is GMP certified, which has had their products lab tested and certified, the best example of this I've managed to track down is Double Wood based out of Philadelphia. They were established in 2013, they are GMP certified with the FDA, and they do submit their supplements to third part labs and they post the certificates. Like I said above, I'd recommend buying direct (in order to minimize the amount of shelf time the item is likely to have logged). They offer a lot of things, including Trans Resveratrol, NMN, as well as Berberine (which may be an alternative to metformin). 1 Geza Szecsenyi Geza Szecsenyi 1 year ago I am Hungarian by birth, but I carry austrian-Jewish blood as well. I live in London UK now in the last 40 years. I do not eat Hungarian food. My father had pot belly. I never wanted to and up like him ! I never had problem with my wait. Always eat healthy, do exercise. I am 66 now, but everibody believes I am around early fifties. I like your research. I am sure you be 150 at list ! That is my personal aim. 3 Jeff Adams Jeff Adams 1 year ago I am a Daivd Sinclair groopie. I feel he is one of the most intelligent Scientists on you tube. I cannot wait for his work to reach its climax. That said I thought that this podcast was not done very well. I felt that Danica was somewhat annoying. As other said she needs to stop interrupting and giggling. It's ok that she does not understand everything he is talking about. But you need to listen quietly. I in no way wanted this to be negative towards your podcast. Just trying to help. Sam P.A. Sam P.A. 1 year ago Genuine interviewer! This is probably the best conversation I've heard of Dr Sinclair. She pushed him, and he shared the goods with those of us outside of that cinical world. Thank you! 4 NUTRITIONAL DIVERSITY NUTRITIONAL DIVERSITY 1 year ago Have Brandon Eisler from The Biodiverse food study in Panama on... He blows this guy away in strength and health and wellness and his stuff is doable for people now. Progress NotPerfection Progress NotPerfection 1 year ago Great show Danicka 2 fashionistajana fashionistajana 1 year ago If she didn't ask the questions and interrupt occasionally, we wouldn't have such a great, insightful interview! Be grateful! 2 Obi z Obi z 1 year ago I want to warn those who want to start HIIT (high-intensity interval training) workouts to activate their longevity genes. I've been doing HIIT workouts during the first quarantine on April and I got a stress fracture in my foot. This type of exercise puts literally a huge amount of stress on our body. It doesn't worth the risk of injury. I'm not even able to walk briskly for last few months. Please be careful and listen to your body - walk briskly or run in a low to moderate pace maybe twice or 3 times a week. 2 MTZ SkunkWorks MTZ SkunkWorks 1 year ago Hell yeah, take the entire nuclear weapons budget and dump it into anti aging! 63 Philippine Yoga Academy Incorporated Philippine Yoga Academy Incorporated 1 year ago I commend the efforts of this show and the excitement of the spectator. However, It would be better if the guest had the chance to finish talking. Unnecessary curious inquiries interrupted the main points... Harry White Harry White 1 year ago I'm almost 10 years further down the road than David and I agree. Don't sweat the small stuff and it's all small stuff. Hurry up with that shot cause I don't have much time left. Progressive ideologies Progressive ideologies 1 year ago I wish i could meet Dr David for cure of mother's aching eyes which is taking away her vision day by day🙏 4 Brogan Josh Brogan Josh 1 year ago "But I haven't won any race car events" Well neither has she https://en.wikipedia.org/wiki/Danica_Patrick Best season for her was 6th. Is she famous for being a decent looking woman driver who is good at furthering her brand? Saw her on the Joe Rogan pod and was wondering what's special about her that we need to hear her thoughts on all kinds of matters Stef Alexandra Stef Alexandra 1 year ago I can see your excitement but you asked him a question then another just as he was about to answer the first one. 57 Seraphim with The Cheese Seraphim with The Cheese 1 year ago It's crazy how he's clearly gotten younger since the Veritasium video. S R S R 1 year ago If you follow racing and know anything about what it takes to drive a race car, it’s more than what the average person is capable of. Along with that comes an ego to match and big egos are sometimes narcissistic. I don’t her personally but was married for 22 yrs to guy who had raced and racing was a part of our life. The thing that was problematic in our relationship is the same thing I l’ve seen in her from the very beginning and that’s narcissism. I’m not saying she’s a narcissist, but she has a lot of tendencies. And if you don’t know anything about narcissism there are many videos that will enlighten you and then it would make sense why she’s the type of interviewer she is, but this is just my opinion and I don’t consider it fact! BatScientist BatScientist 1 year ago Danica. Nice interview. Easiest way to say it is rez-vera-troll 1 Ruby Kazmierak Ruby Kazmierak 1 year ago An amazing and captivating man but I found the video hard to watch because the interviewer didn't match the tone of her soft-spoken guest. David has a very calm presence and is very easy to listen to - in contrast, Danica's questions and input sounded a bit like teenage outbursts......I suppose she intermittently stressed my system which might actually have some longevity benefits! 31 Adrian Saw Adrian Saw 1 year ago Make sure his research is safe and not hacked. Then let us know when he will tokenised or list his company maldives-joshua joseph maldives-joshua joseph 1 year ago If you are speaking and somebody interrupts, would you like it ? Thanks for the hard work of producing this video. 3 Mario Rodriguez Mario Rodriguez 1 year ago Amazing !!!!👍🏼🇲🇽 Springteen Springteen 1 year ago There is no such thing as aging nor death but there is always a process in all and without your concern. David Macdonald David Macdonald 1 year ago Lot of criticism of the host(ess). When a world renowned figure, who is interviewed constantly, admits to that host that he is about to reveal personal information - so personal that he admits to never having discussed it in public before - then you know you are watching a talented journalist, no matter how much she interrupts. Dr. Sinclair didn't seem to mind, in any case. 2 m saz m saz 1 year ago I wonder if it can reverse menopause and when we will reach there? 4 Be Kind Be Kind 1 year ago (edited) With all due respect- Filter your words...... please, please, let David speak........choose your questions carefully, do not overpower the conversation..... Elegance and toning down your voice is golden, pace yourself......things you should acquire to have successful interviews. Take this advice as an asset feedback, not criticism. Blessings to you 7 Kenz300 x Kenz300 x 1 year ago (edited) Leave the world a better place than when you came. Too many people are selfish, self centered and greedy. It is good to hear about people doing good thing for others. Seems like parents and teachers stopped teaching the "Golden Rule" about 30 years ago. Donte Beachem Donte Beachem 1 year ago I wish he could talk at length and allowed to elaborate more as he continued on each subject asked. 2 NoName NoName 1 year ago If you can reverse age, what stops someone from reversing a dead organism ? That would in theory be possible. Reversal after death ? life life 1 year ago Danica, you should improve how you do interviews by learning how to give the guest time to speak before you interrupt. You talk to much😖 30 Balasubramaniam Kajanan Balasubramaniam Kajanan 1 year ago Can olive oil or reservatrol only activate sitruins?? Or must need to take with NAD supplements 1 dogmutty2 dogmutty2 1 year ago We weren't created to live very long in the flesh, however, the soul lives on forever 3 Progressive ideologies Progressive ideologies 1 year ago Beautiful last message 1 Sam P.A. Sam P.A. 1 year ago This must be an older interview? I'm pretty sure I bought the book a few years ago, or is there another book? 2 Hidden Marty Hidden Marty 1 year ago (edited) 27:33 Let's make our bodies young again :D #voteSinclair2020 :P 3 Velocity Girl Velocity Girl 9 months ago This is third interview today where the host was self deprecating because he’s brilliant. Such a bummer. matt jensen matt jensen 1 year ago life that is past on, is eternal. when the memories, you have come from many lifetimes before you, death has ended and the kingdom of heaven is before you.... loss of identity is what man See's as death, while eternal life surrounds us 3 Fide Logos Fide Logos 1 year ago Danica is a beautiful, accomplished woman but I came to the interview to hear David. She should ask the questions and not interrupt. 17 Anonymous Anonymous 1 year ago (edited) This is why you don't give a platform to an interviewer that doesn't have the talent for it. Blue Fairy Blue Fairy 1 year ago she is too exciting to interview him on a normal basis AKlover AKlover 1 year ago Fasting happens fairly naturally with the carnivore diet........................... After eating a pound of fatty beef and 4 eggs not eating for well over 12 hours becomes common. Your metabolism changes after a few days which obviously changes how often you eat. 1 Stephie Getsit Stephie Getsit 1 month ago (edited) 1:05 ish , Joe Rogan also drinks lots of Alcohol and smokes drugs and cigars so not the ultimate authority to follow for life management. And for those of you who want to jump on this statement get a live blood analysis done. Then drink alcohol and smoke either some weed or a cigar and get the live blood analysis redone and watch what happens. Everything slows down in the blood. Joe has flaws as well he knows better but he still does what he does, and lives life the way he likes. Be Kind Be Kind 1 year ago Let him talk.... please. All the small talk it is SO unnecessary... A previous time with a brilliant man wasted with interruptions and rumbling... we came to your site to listen to him... An opportunity for you to get highlighted.... Respecting the speaker's style of talking and let him flourish in the interview is PARAMOUNT. I sadly didn't see it here...☝️😔 2 Rita Ricci Rita Ricci 1 year ago Ponce Deleon did find the fountain of youth! Warm Mineral Springs, North Port, Florida. 1 Paul Clarke Paul Clarke 1 year ago He pulled apart dead animals as a kid 😧... that's how Jeffrey dahmer got his interest in cannibalism... I'd be watching Dr.David Sinclair 🤔 2 Vlasta FF Vlasta FF 1 year ago Excellent interview. Sinclair is not annoyed by her questions!!! All of you, obviously successful women haters, posting stupid comments about her interrupting. 3 nafura chan nafura chan 1 year ago It is rather frustrating seeing her interrupt him and ask him another questions whenever he tried to elaborate his point 7 History Dave History Dave 1 year ago Stop interrupting your guest. 69 Clownfish Depot Clownfish Depot 1 year ago What glucose monitor does David wear? 2 Jackl cooper Jackl cooper 5 months ago