The Science of Keeping the Brain Healthy | Lifespan with Dr. David Sinclair #7 193,417 viewsFeb 16, 2022

The Science of Keeping the Brain Healthy | Lifespan with Dr. David Sinclair #7 193,417 viewsFeb 16, 2022 David Sinclair 171K subscribers In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. #DavidSinclair #Longevity #BrainHealth Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introducing Episode Seven: Aging of the Brain 00:04:39 Thanking the Sponsors 00:07:38 Ex-differentiation as a Driver of Aging 00:09:22 The Brain Ages Slowly 00:14:17 Cognitive Function and Plasticity 00:17:44 Three Longevity Pathways: mTOR, AMPK, and Sirtuins 00:23:26 Plant-based Diets and B-vitamins 00:28:32 Homocysteine, Plaque, and Vasculature 00:32:35 Fatty Acids 00:35:48 Physical Activity 00:39:14 Metformin 00:46:02 NAD Boosters 00:50:33 Increasing Blood Flow 00:53:20 Sleep 00:58:02 Overall Message: Keep your Brain Healthy 00:58:50 Next Week’s Episode and the Future of Medicine 01:01:21 Options for Subscription for Support Links: The cerebellum in the brain ages slowly: https://bit.ly/3JC9CLL Neuronal cells have a lower epigenetic age: https://bit.ly/3HVZsVA Sirt1 regulates aging in mice: https://bit.ly/3sGZPNC Mediterranean diet and brain health: https://bit.ly/3uUpYuL Mediterranean diet and dementia risk: https://bit.ly/34Igp7H Aerobic exercise improves executive functioning: https://bit.ly/34Dv5oJ Exercise and mouse models of neurodegenerative disease: https://bit.ly/3516IRn Strength exercises elevate the expression of BDNF: https://bit.ly/3GTLqCs Metformin enhances cognitive ability in fish: https://bit.ly/3sLtWn2 Alzheimer’s disease and metformin: https://bit.ly/3GSdTJ5 Metformin use correlates with a reduced risk of dementia: https://bit.ly/3GT0KPO NAD boosting and Alzheimer’s disease: https://bit.ly/367C2P2 ALS, nicotinamide riboside, and pterostilbene: https://bit.ly/3Bm2VKN Vascular aging and NAD in mice: https://bit.ly/34Uemgx In mice, overexpressing Sirt1 in the brain extends lifespan: https://bit.ly/3HNRyh3 Sirt1 ameliorates amyotrophic lateral sclerosis in mice: https://bit.ly/3LvUWiO Sirt1 protects against Alzheimer’s disease in mice: https://bit.ly/34KZXUe Sirt1 and neuroprotection in a mouse model of Huntington’s disease: https://bit.ly/3BqymDJ Sleep loss reduces lifespan in flies: https://bit.ly/3Jt6BgA A single night of sleep deprivation increases amyloid-beta: https://bit.ly/3uSNGaU All-cause mortality correlates with sleep duration: https://bit.ly/3rQl14f Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters Introducing Episode Seven: Aging of the Brain 0:00 Thanking the Sponsors 4:39 Ex-differentiation as a Driver of Aging 7:38 The Brain Ages Slowly 9:22 Cognitive Function and Plasticity 14:17 Three Longevity Pathways: mTOR, AMPK, and Sirtuins 17:44 856 Comments rongmaw lin Add a comment... 19Jetta 19Jetta 2 months ago I know I say it almost every week, but thank you again for doing this podcast. I am aware it takes your time and effort and no doubt you have lots of other things you could be doing. This is just an incredible resource! 130 J2.A.M.p Thomas J2.A.M.p Thomas 2 months ago I don’t typically comment, but wanted to confirm that I appreciate Matt’s role (cohost) in this podcast. He tends to ask the very questions I have as a listener. 204 Sheila Bella Sheila Bella 1 month ago What a great episode! Thank you both! I have to agree with the others who commented that MATT’s role in this is KEY! I never comment but I just had to say how I have an easier time learning this stuff because of his participation. 18 Jeana Shchuchinov Jeana Shchuchinov 2 months ago I love your podcast, I can’t get enough. I was happy to hear you are going to have a season two lol 24 mitch becker mitch becker 2 months ago Main takeaway, "Without a functioning brain, we are really quite useless." -Dr. David Sinclair. 88 SirGolfAlot SirGolfAlot 1 month ago (edited) Dr. Sinclairs' videos are an inspiration. I was exercising, fasting, eating right, and taking supplements until the spring of 2020. Time to get focused on longevity once again. 8 HardForking HardForking 2 months ago The best podcast I've found. You guys are fantastic, please keep this going. I've followed David's works for a number of years and put him right up there as one of the best humans we have on this planet. 15 Pops Pops 2 months ago I feel so blessed to have found this podcast at 24, thank you both tremendously🤟🏻 26 Ceci Palacios Ceci Palacios 2 months ago Great podcast! As a 68 years old my focus in healthy aging! Thus, I completely agree with Dr Sinclair said that we need to take care of our brain not only for us but for our family as well. 32 sciencensorcery sciencensorcery 2 months ago Folic acid is not B-12. It's the synthetic form of folate, which is B-9. Many people are unable to properly utilize folic acid and need to take folate — but some people also need that folate to be pre-methylated. And others can react poorly to methylated folate (I experienced this myself a few months ago and the effect was staggering). It's a bit complex but worth looking into before you supplement (or if you start and don't take to it well) so you know which form you need! 119 Sunshine City Personal Training Sunshine City Personal Training 2 months ago Really enjoying the progression of these, excited for the next episode! 21 Stephen Young Stephen Young 1 month ago As an extremely busy professional and getting a little older, I enjoy learning about avenues that could help keep me optimizing my overall function/performance. Great podcast and the 2 hosts work really well together. 3 Sandra Thomas Sandra Thomas 1 month ago I was extremely impressed by this podcast. I learned a great deal of new things. I would love for you to follow up another podcast series. Shelley Huskey Shelley Huskey 2 months ago David you are a special person! Thanks for everything you do. I have learned so much from you and your books. 5 Brendan Fox Brendan Fox 1 month ago That was a brilliant podcast , David . So interesting . Keep up your good work , well done . T.J. Robertson T.J. Robertson 1 month ago I look forward to watching these podcasts. Thank you for sharing your life’s work 💙 Mohandas Gandhi Mohandas Gandhi 2 months ago "Today we'll be talking about the most important organ in the body, the brain." -David's Brain 60 Claudette Sechler Claudette Sechler 2 months ago Just look forward to your podcast..it is so innovating and love hearing about the wonderful things about the health field that I can apply to myself! Just wish I could have dinner earlier instead of later but it is a special time to enjoy a great meal, glass of wine with my hubby and chit chat, laugh, listen to great music..that’s a great health fix for me!! 4 Isabelle Ebel Isabelle Ebel 2 months ago Thank you so much for this great podcast! would like to know if it is ok to take Metformin and Resveratrol with the same meal all at once or would this reduce/inhibit the positive effects? 5 Jane Lessa Jane Lessa 2 months ago Special thanks to Dr. Sinclair for delivering true science to our homes. I love neuroscience, so this is a fantastic episode!I Also would like to comment that the conversation format is great. Matt does a really good job. Tks everyone that makes this happen. 6 Calvin Scott Calvin Scott 2 months ago Thank you guys so much for doing what you do! It’s really mind opening learning from you Mr. Sinclair. I have one question that you may be able to shed some light on. Is any kind of intermittent fasting acceptable if one is missing their gallbladder? 1 stephen lucier stephen lucier 2 months ago This is amazingly informative, please don’t stop at 8! 16 Alice Clark Alice Clark 1 month ago Thank you for making this podcast. If you guys continue with the podcast, I would greatly appreciate further elaboration on this topic. I am only 29, but my brain has deep white matter lesions, which are very uncommon at my age, but very common in the elderly. If you guys could explore the research on this topic, it would be greatly appreciated. I've been looking into as many papers as i can find on the topic, but I don't have the same access to the journals that you have. Thank you LCarefortheworld LCarefortheworld 1 month ago Thank you for doing the podcast! Feeling lucky I get these incredible information from the source I can trust! 1 Patricia Soza Patricia Soza 2 months ago I just love this podcast. Thank you for sharing all this information! 5 Frances Torrey Sirdevan Frances Torrey Sirdevan 2 months ago Best podcast ever. Love and appreciate the work you both and your team do and share. Thank you all!! A question about fasting for David: what do you prescribe for your children? Is one meal a day your recommendation to anyone of any age? If not, what age do you recommend starting that protocol? Additionally, I wanted to share that algae oil is a perfect vegan EPA/DHA source/supplement that circumvents the fish oil route. In fact, it’s what the omega 3 rich fish consume too! Highly recommended! 3 ritim ritim 2 months ago one of the few person on youtube that i deeply respect , thanks David for all of fantastic work and sharing to public. 6 Vicky Daisy Vicky Daisy 1 month ago Love both of you and your podcast. Thank you for making it happens. 1 Dede Koll Dede Koll 1 month ago yes..please keep going with this podcast! It is so very important for us all. 1 Felix Sosa Felix Sosa 1 month ago Something I've been wanting David to take a shot at answering: what is (roughly) the appropriate age to begin with some of these interventions? For example, should I start taking supplements (NMN, Resveratrol) at 30? Late 20s? Late 30s? Or should all of these questions be determined by blood tests? Michael Allen Michael Allen 2 months ago (edited) I love this casual, engaged and authentic conversation. I'm more a creative writer/philosopher than a scientist. But I thank god for good scientists like these two. I think we're coming into a better age -- the age of conversation (which has always been my greatest teacher), wherein the sound bite media slowly, and quite painfully, dies. 5 monster paw monster paw 1 month ago Probably going to need to watch these 100 more times 🤯 Thank you for making these videos 🥰🙏 1 qski1 qski1 1 month ago Looking forward to the next season, please continue! I would be interested the most in the effect of excercise (various types/cardio/weights) on aging. max adams max adams 1 month ago I have enjoyed your series very much. Thank you for the information. I would like to hear more about peptides if you do future podcasts. Mrs Shetty Mrs Shetty 2 months ago Best podcast / YT! So glad this channel was created it really easy to follow and so much valuable information. X 2 Paige Walker Paige Walker 3 weeks ago This episode was the one that finally got me to share this with my parents- the others were super inspiring to me, but not enough to make me feel like my elderly parents might actually take action. "The Average onset of dementia is 80 years old" - this episode made me feel like I'm doing a disservice NOT to share this with my parents! Thank you for making this info available to the masses! George Rodriguez George Rodriguez 2 months ago Thanks for doing this podcast. Very good information, live changing. TheBladeMasterOfLove TheBladeMasterOfLove 2 months ago (edited) Exceptionally episode as always. You really complement each other well! Jessica Bennett Jessica Bennett 2 months ago Love these podcasts! Two questions. I see several pts with elevated B12, is this of concern or does it indicate anything? Also, is there a list of recommended targeted levels of each vitamin we should reach to have optimal levels not just ones in the “normal” range? Thank you! Brenda Spalding Brenda Spalding 3 weeks ago David I’ve seen you on Joe Rogan’s podcast. You’re one my favorite guest. I’m so happy that you’re doing your own podcast. I love Joe but I love him more when he has people like you on. I’m a fan. I hope you keep it going. abe rezz abe rezz 1 month ago I just subscribed to Dr S. channel.. having followed his lectures in the past .. thank you for the awesome stuff..