Lifespan with Dr. David Sinclair #7

The Science of Keeping the Brain Healthy | Lifespan with Dr. David Sinclair #7 191,607 viewsFeb 16, 2022 6.3K DISLIKE SHARE DOWNLOAD CLIP SAVE David Sinclair 170K subscribers In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. #DavidSinclair #Longevity #BrainHealth Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introducing Episode Seven: Aging of the Brain 00:04:39 Thanking the Sponsors 00:07:38 Ex-differentiation as a Driver of Aging 00:09:22 The Brain Ages Slowly 00:14:17 Cognitive Function and Plasticity 00:17:44 Three Longevity Pathways: mTOR, AMPK, and Sirtuins 00:23:26 Plant-based Diets and B-vitamins 00:28:32 Homocysteine, Plaque, and Vasculature 00:32:35 Fatty Acids 00:35:48 Physical Activity 00:39:14 Metformin 00:46:02 NAD Boosters 00:50:33 Increasing Blood Flow 00:53:20 Sleep 00:58:02 Overall Message: Keep your Brain Healthy 00:58:50 Next Week’s Episode and the Future of Medicine 01:01:21 Options for Subscription for Support Links: The cerebellum in the brain ages slowly: https://bit.ly/3JC9CLL Neuronal cells have a lower epigenetic age: https://bit.ly/3HVZsVA Sirt1 regulates aging in mice: https://bit.ly/3sGZPNC Mediterranean diet and brain health: https://bit.ly/3uUpYuL Mediterranean diet and dementia risk: https://bit.ly/34Igp7H Aerobic exercise improves executive functioning: https://bit.ly/34Dv5oJ Exercise and mouse models of neurodegenerative disease: https://bit.ly/3516IRn Strength exercises elevate the expression of BDNF: https://bit.ly/3GTLqCs Metformin enhances cognitive ability in fish: https://bit.ly/3sLtWn2 Alzheimer’s disease and metformin: https://bit.ly/3GSdTJ5 Metformin use correlates with a reduced risk of dementia: https://bit.ly/3GT0KPO NAD boosting and Alzheimer’s disease: https://bit.ly/367C2P2 ALS, nicotinamide riboside, and pterostilbene: https://bit.ly/3Bm2VKN Vascular aging and NAD in mice: https://bit.ly/34Uemgx In mice, overexpressing Sirt1 in the brain extends lifespan: https://bit.ly/3HNRyh3 Sirt1 ameliorates amyotrophic lateral sclerosis in mice: https://bit.ly/3LvUWiO Sirt1 protects against Alzheimer’s disease in mice: https://bit.ly/34KZXUe Sirt1 and neuroprotection in a mouse model of Huntington’s disease: https://bit.ly/3BqymDJ Sleep loss reduces lifespan in flies: https://bit.ly/3Jt6BgA A single night of sleep deprivation increases amyloid-beta: https://bit.ly/3uSNGaU All-cause mortality correlates with sleep duration: https://bit.ly/3rQl14f Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters Introducing Episode Seven: Aging of the Brain 0:00 Thanking the Sponsors 4:39 Ex-differentiation as a Driver of Aging 7:38 The Brain Ages Slowly 9:22 Cognitive Function and Plasticity 14:17 Three Longevity Pathways: mTOR, AMPK, and Sirtuins 17:44 854 Comments rongmaw lin Add a comment... J2.A.M.p Thomas J2.A.M.p Thomas 2 months ago I don’t typically comment, but wanted to confirm that I appreciate Matt’s role (cohost) in this podcast. He tends to ask the very questions I have as a listener. 202 mitch becker mitch becker 2 months ago Main takeaway, "Without a functioning brain, we are really quite useless." -Dr. David Sinclair. 88 Mohandas Gandhi Mohandas Gandhi 2 months ago "Today we'll be talking about the most important organ in the body, the brain." -David's Brain 60 19Jetta 19Jetta 2 months ago I know I say it almost every week, but thank you again for doing this podcast. I am aware it takes your time and effort and no doubt you have lots of other things you could be doing. This is just an incredible resource! 129 sciencensorcery sciencensorcery 2 months ago Folic acid is not B-12. It's the synthetic form of folate, which is B-9. Many people are unable to properly utilize folic acid and need to take folate — but some people also need that folate to be pre-methylated. And others can react poorly to methylated folate (I experienced this myself a few months ago and the effect was staggering). It's a bit complex but worth looking into before you supplement (or if you start and don't take to it well) so you know which form you need! 119 Yayang Tapir Yayang Tapir 2 months ago Mathew is looking younger day by day....I think he is listening to david to start all the supplements. His collection of hats is awesome...😁😃 11 Sheila Bella Sheila Bella 1 month ago What a great episode! Thank you both! I have to agree with the others who commented that MATT’s role in this is KEY! I never comment but I just had to say how I have an easier time learning this stuff because of his participation. 18 Pops Pops 2 months ago I feel so blessed to have found this podcast at 24, thank you both tremendously🤟🏻 26 Chris Grant Chris Grant 2 months ago Please can you respond to Dr Brad Stanfield regarding resveratrol. He has made a few videos on this. Thankyou! 29 SirGolfAlot SirGolfAlot 1 month ago (edited) Dr. Sinclairs' videos are an inspiration. I was exercising, fasting, eating right, and taking supplements until the spring of 2020. Time to get focused on longevity once again. 8 Ceci Palacios Ceci Palacios 1 month ago Great podcast! As a 68 years old my focus in healthy aging! Thus, I completely agree with Dr Sinclair said that we need to take care of our brain not only for us but for our family as well. 32 Aman Sharma Aman Sharma 2 months ago What do we know about lifestyle protocols not related to diet/sleep and how they age the brain? For example reading, spaced repetition, music, cognitive training, new experiences etc? Andrew Huberman’s episode on how play impacts plasticity was really interesting, so I’m curious how this all ties into ageing. 12 stephen lucier stephen lucier 2 months ago This is amazingly informative, please don’t stop at 8! 16 Jeana Shchuchinov Jeana Shchuchinov 2 months ago I love your podcast, I can’t get enough. I was happy to hear you are going to have a season two lol 24 Inputoutput Fitness Inputoutput Fitness 2 months ago Practical takeaways you can implement immediately: Get good quality adequate sleep, exercise, eat well and ensure you are getting enough essential fats. 9 Biplob Paul Biplob Paul 2 months ago One thing is to say, olive oil is a must. 4 snow white snow white 1 month ago (edited) 52:37 I think he meant the Hypothalamus! Thank you so much for this. VictorSneller VictorSneller 2 months ago Hey, he’s doing a good job man! Leave him alone! 6 Moses Rabuka Moses Rabuka 3 weeks ago “The brain ages slower than the rest of the body, significantly slower. Your brain is biologically younger than you are” 1 HardForking HardForking 1 month ago The best podcast I've found. You guys are fantastic, please keep this going. I've followed David's works for a number of years and put him right up there as one of the best humans we have on this planet. 15 Sunshine City Personal Training Sunshine City Personal Training 2 months ago Really enjoying the progression of these, excited for the next episode! 21 Mum2cuties Mum2cuties 1 month ago (edited) I’m an optometrist and I’m glad you emphasised the importance of an eye examination to assess general vascular health. 1 Youtube Iscruel Youtube Iscruel 2 months ago Wow hes been taking athletic greens for years! Amazing he has forgotten to mention it in his publicized supplement stack until he was being paid to say he takes it. What a coincidence! 6 Michele M Michele M 2 months ago (edited) I've been vegan for 20+ years. B12, not folate is definitely the most important to supplement with for brain health on a vegan diet. Permanent damage to the nervous system can happen with prolonged deficiency. For Omega-3s, the recommendation is 1 Tablespoon ground flaxseed per day or to take algae-based supplement for vegans. The algae-based supplements are expensive but more reliable than flaxseed. 13 Brenda Spalding Brenda Spalding 3 weeks ago David I’ve seen you on Joe Rogan’s podcast. You’re one my favorite guest. I’m so happy that you’re doing your own podcast. I love Joe but I love him more when he has people like you on. I’m a fan. I hope you keep it going. Sumit Panwar Sumit Panwar 2 months ago (edited) It would be Good If you Guys could Give 1-2 Daily Simple Practice at the end of each episode related to that topic which everyone can follow since not everyone can afford various drugs,tests n medicine etc. 3 Altiaris Suralis Altiaris Suralis 2 months ago Thank you Dr. Sinclair, been following you for a while. 👍 Recently, there’s been some debate and pushback from Dr. Charles Brenner, and as a layperson I can’t seem to understand all the technical details. Can you eventually shed some light on this disagreement? Thanks. 6 Shelby Smith Shelby Smith 2 days ago Love the podcast, just finished this episode. One question I'd love you to address in everything you talk about is "How does this apply to pregnant/breastfeeding women?" Supplementation, fasting, all the stuff from the "cosmetic" episode, healthy levels of xyz for your brain health, and maybe some ways to bounce back and recover after being sleep deprived as a pregnant woman/new parent... I'm recently fascinated with longevity and age-reversal techniques and I discovered your podcast while pregnant with my first. Of course, everywhere else I look for information online says you can't fast while pregnant or breastfeeding, you can't take any supplements, and you need a ton of folic acid. I just learned today that high levels of folate in pregnant women could be linked to giving birth to a child with autism. I would just love it if you would address or point me to research on the how the staples of "Lifespan" may differ (or be the same) for pregnant and breastfeeding women. Thank you! I think I'll write an article breaking down season 1 of the pod because I really want to internalize your research and help spread the message, especially to my loved ones. Vee Hope Vee Hope 2 months ago Red wine red wine yeah yeah yeah, what about the alcohol in red wine? Studies now show there is no safe amount of alcohol. Talk about that. 5 Sharyn the vegan Sharyn the vegan 2 months ago I don't think we're living longer, I think we're just dying slower... 1 ritim ritim 2 months ago one of the few person on youtube that i deeply respect , thanks David for all of fantastic work and sharing to public. 6 Vincent ACK Vincent ACK 1 month ago I would love to hear david more explaining more without the hosts interruptions Dede Koll Dede Koll 1 month ago yes..please keep going with this podcast! It is so very important for us all. 1 monster paw monster paw 1 month ago Probably going to need to watch these 100 more times 🤯 Thank you for making these videos 🥰🙏 1 Jeff Nixon Comedy Jeff Nixon Comedy 2 months ago I know my brain is young because it still thinks farts are hilarious. 28 Shelley Huskey Shelley Huskey 1 month ago David you are a special person! Thanks for everything you do. I have learned so much from you and your books. 5 Jawad Karim Jawad Karim 2 months ago A Big Salute for David Sinclair. 3 chris tinley chris tinley 2 weeks ago Ok… im still waiting for the next season to start.. will there be another? I check ev monday… please… make…. More… videos lol!!!!! Andreas Stuermer Andreas Stuermer 2 months ago (edited) Is there a commercial service that you can send cells to, so they measure the DNA methylation clock using the Horvath algorithm? 1 whatUneverknew whatUneverknew 9 days ago Rofl. That executive function joke slayed me! 🤣🤣🤣 Shyrine Kessentini Shyrine Kessentini 2 months ago Can you please do a podcast about repairing the cells in the body caused by cancer treatments, stress, radiation…thx 8 Where Nerdy is Cool! Where Nerdy is Cool! 2 months ago I'd be really curious his thoughts on resveratrol pterostilbene 2 Tahelle Wythet Tahelle Wythet 2 months ago yeah but, can you wiggle your eyebrows? 2 Isabelle Ebel Isabelle Ebel 2 months ago Thank you so much for this great podcast! would like to know if it is ok to take Metformin and Resveratrol with the same meal all at once or would this reduce/inhibit the positive effects? 5 Explorers of the World Explorers of the World 1 month ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept RealFoodRevolution RealFoodRevolution 1 month ago I heard that MCT oil is amazing for the brain!! Kunal Singh Rathore Kunal Singh Rathore 2 months ago (edited) Let’s Go..As much as I am excited to hear each episode, it makes me countdown to the last couple of episodes left.😣 3 rebaked rebaked 2 months ago Right. There is no point in reaching 100yo if you can't remember the faces of loved ones 1 MrEtc31265 MrEtc31265 2 months ago I have started using a Far Infra Red sauna blanket that I believe is improving my blood circulation. Any thought on Astaxanthin as a supplement? Thanks. 3 Claudette Sechler Claudette Sechler 2 months ago Just look forward to your podcast..it is so innovating and love hearing about the wonderful things about the health field that I can apply to myself! Just wish I could have dinner earlier instead of later but it is a special time to enjoy a great meal, glass of wine with my hubby and chit chat, laugh, listen to great music..that’s a great health fix for me!! 4 Mysteroo Mysteroo 1 month ago I've read that folic acid is something you actually want to avoid- whereas folate is what we need more of Patricia Soza Patricia Soza 2 months ago I just love this podcast. Thank you for sharing all this information! 5 Stephen Young Stephen Young 1 month ago As an extremely busy professional and getting a little older, I enjoy learning about avenues that could help keep me optimizing my overall function/performance. Great podcast and the 2 hosts work really well together. 3 Jane Lessa 1 month ago Special thanks to Dr. Sinclair for delivering true science to our homes. I love neuroscience, so this is a fantastic episode!I Also would like to comment that the conversation format is great. Matt does a really good job. Tks everyone that makes this happen. 6 SK. N. SK. N. 1 month ago Best recommendations for brain health are Drs. Sherzai (both neurologists). Am shocked that too much of what Sinclair says is either incomplete or false. 1 Michael James Squires Michael James Squires 1 month ago Aussie, Aussie, Aussie! I actively promote you for free, send me some Resveratrol as commission 🤣🤣🤣 palden palden 2 months ago I am 58. Most of my years, after my 'teenage slim time', I was about 10 pound overweight. Around at 45 I developed some knee pain for many years and like so many of my pals, I thought it is just the body worn out because of the hard work as a nurse. So, it is just normal life...! But then I discovered the Ketogenic diet, and after 2-3 weeks my knee pain was gone and never come back. I almost never experience ANY pain at all in my body. If I tell this to my oldest sister, 62, that she should stop eating sugar and do low carb eating, she screams at me: "My body, and knees are worn out, nothing can bring it back!!". She just don't believe me, that the sugar and carbs is the ONE who give the inflamation and the pain, AND it is reversable! It's sad, that almost no one knows, that with eating low carb and no sugar, all the inflamation will be gone and one will feel normal again!! It should be called out from the Rooftop! 23 Michael Allen Michael Allen 2 months ago (edited) I love this casual, engaged and authentic conversation. I'm more a creative writer/philosopher than a scientist. But I thank god for good scientists like these two. I think we're coming into a better age -- the age of conversation (which has always been my greatest teacher), wherein the sound bite media slowly, and quite painfully, dies. 5 T.J. Robertson T.J. Robertson 1 month ago I look forward to watching these podcasts. Thank you for sharing your life’s work 💙 Sofian Chaybouti Sofian Chaybouti 2 months ago The discussion about alzheimer’s reminds me the planet of the apes: the origins Lorie J Lorie J 2 months ago Love this topic! 1 Creighton Freeman Creighton Freeman 2 months ago Omega-3 fatty acids are plant oils. Algae (sea weed) is the best source of them. The only reason fish have Omega-3s in them is because they eat algae or smaller fish that eat algae. You can skip the fish and go direct to the source. There are a few companies that sell algae derived omega-3. The Only draw back to them at the moment is that because the volume sales is less than fish oils, the price is currently higher. You are less likely to get bio-accumulated pollutants from the algae derived oils than from the fish though. Pollutants increase in concentration the higher up you go on the trophic level. 6 Sandra Thomas Sandra Thomas 1 month ago I was extremely impressed by this podcast. I learned a great deal of new things. I would love for you to follow up another podcast series. William Nunn William Nunn 1 month ago thank you david for the advice on NMN. I am going to get on this quick, as i have chronic insomnia at the moment, from mental health. i exercise with HIIT and calisthenics. i take zinc, vitamin d and ashwaghanda but realise this is not enough at the moment. Jean Claude Charles Jean Claude Charles 2 months ago Thanks a lot for these informations I can use to better myself, and for this huge service you're doing for humanity. You're a GOD inspired Soul. 2 Natalie Axl Natalie Axl 2 months ago Thank you, Dr, David 🙏 2 Eddie Hanson Eddie Hanson 2 months ago Thank you. This is life-changing viewing. Jeff Willems 2 months ago What about creatine as a supplement? Good to fight ageing when combined with exercise or bad as a signal that resources are plentiful? 1 Brendan Fox 1 month ago That was a brilliant podcast , David . So interesting . Keep up your good work , well done . KD Counseling 2 months ago Perfect timing thank you 😊 2 Kantraj K 2 months ago Thank you so much ❤️🙏 2 Péťa 2 months ago Blessed day with new upload. Thank you! Starving Samoan 2 months ago Love Matts hats and overall sense of fashion. 1 Ligia Sommers 2 months ago (edited) Best podcast !!! And I study many of them !!!! 🙏🏻✨🌹🌟🌟🌟🌟🌟 I am using AGreens and will check the others 1 Ian Baber 2 months ago "My brain? That's my second favorite organ." Woody Allen. max adams 1 month ago I have enjoyed your series very much. Thank you for the information. I would like to hear more about peptides if you do future podcasts. PRATHU TAYADE 2 months ago :) susy may 2 months ago Great timestamps! Robert Fox 2 months ago Thank you! abe rezz 1 month ago I just subscribed to Dr S. channel.. having followed his lectures in the past .. thank you for the awesome stuff..