Lifespan with Dr. David Sinclair #3--Exercise, Heat, Cold & Other Stressors for Longevity

Exercise, Heat, Cold & Other Stressors for Longevity | Lifespan with Dr. David Sinclair #3 In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels. #Exercise #DavidSinclair #Longevity Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introducing Episode Three: Exercise Hot Cold 00:01:01 A Pernicious Element Called Iron (Fe) 00:02:46 A Quick Primer on Free Radicals 00:05:42 Review of Dietary Takeaways 00:07:01 Acknowledging the Sponsors 00:09:32 Biological Adversity and the Survival Circuit 00:13:24 Survival Sensors (i.e., mTOR, AMPK, and Sirtuins) and Communicators (e.g., Insulin) 00:17:25 Get Off Your Butt 00:19:40 Exercise Protects against Disease and Mortality 00:21:17 Daily Step Count and Walking After Eating 00:22:33 Exercise Activates AMPK and Creates More Mitochondria 00:24:03 Vigorous Exercise, Hypoxia, and the Electron Transport Chain 00:28:19 Exercise Increases Glucose Sensitivity and Stimulates Blood Vessel Formation 00:32:13 The Epigenome and Biological Age are Impacted by Exercise 00:36:43 How to Measure your Biological Age 00:37:31 Exercise Recommendations 00:39:28 Wearables and Individualized Health Tracking 00:43:14 The Importance of Weight Training 00:46:08 Physical Activity and Senescent Cells 00:48:01 Exercise Wrap-up and Takeaways 00:49:47 Hyperbaric Oxygen Therapy (HBOT) 00:57:24 Cold Therapy 01:03:50 Applying Heat 01:07:04 Adversity Mimetics Produce Endorphins 01:08:07 A Basic Protocol for Mimicking Adversity 01:10:04 Next Week’s Episode: Molecules and Supplements 01:10:45 Options for Subscription and Support Links: A single mutation doubles lifespan in worms: https://go.nature.com/33QhCsV Extending lifespan in yeast with one mutation: https://bit.ly/3FSDf9n Daily step count and health outcomes: https://bit.ly/3ruVlsD Reversing vascular aging in mice: https://bit.ly/3rwCYDz Aerobic exercise is linked to a lower biological age: https://bit.ly/33pQTUf A lifestyle and diet intervention decreases biological age: https://bit.ly/3fzyuqi An epigenetic clock that predicts time-to-death: https://bit.ly/3rz4yAp Ultra-cheap age prediction: https://bit.ly/3nFeTto Exercise decreases biomarkers of cellular senescence: https://bit.ly/3AbYSQC Telomere length is increased by hyperbaric oxygen therapy: https://bit.ly/3Aff57x Hyperbaric oxygen therapy improves cognitive performance: https://bit.ly/3GGCzoL A cold temperature promotes longevity in worms: https://bit.ly/3FHy7om Sauna bathing, mortality, and cardiovascular risk: https://bit.ly/33P09RC Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters Introducing Episode Three: Exercise Hot Cold 0:00 A Pernicious Element Called Iron (Fe) 1:01 A Quick Primer on Free Radicals 2:46 Review of Dietary Takeaways 5:42 Acknowledging the Sponsors 7:01 Biological Adversity and the Survival Circuit 9:32 860 Comments rongmaw lin Add a comment... LYZABETH LOPEZ - Fitness & Nutrition LYZABETH LOPEZ - Fitness & Nutrition 2 months ago Obsessed with this podcast! Recommending all my clients follow along too so we can all learn together and have discussions 28 Juan Pablo Aranovich Juan Pablo Aranovich 2 months ago This was another great episode! Learning so much. Just sharing my notes here. Too much iron is dangerous for longevity. Drives the accumulation of zombie cells. Survival sensors: - Mtor: senses amino acids. Lower levels of BCAAs are good - Ampk: senses energy (glucose). - Sirtuins: sense NAD (goes up and down with food and exercise) Insulin tells the body that's there sugar to use. -Exercise prevents diseases. Reduces mortality. -Walking after a meal stimulates the production of new blood vessels and turns on ampk (registers energy -atp-). -Vigorous exercise. Low levels of oxygen (Hypoxia) are good (though doesn't feel good). -As we get older, our muscles become less sensitive to the insulin that the pancreas is putting out. This is due to aging. -glucose in the bloodstream damages blood vessels. -Exercise impacts epigenome (regulator of DNA). -80% of future health is manipulable and modifiable (epigenome) Weight training: - Maintain hormone levels, ability to walk well and have good posture, makes look better - Is hard to get muscle as you get older. - Breaking your hips is equivalent to have stage 4 cancer. Mortality rates are that bad after hip injury. ○ How to avoid breaking hips? Build muscle and work on flexibility. - Senescent cells: when the epigenome becomes deregulated, cells can either die or they can be shut down, so they are zombie cells. Slowing the formation of zombie cells or killing them is important. Exercise kills these cells. Hyperbaric Oxygen Therapy (HBOT) - Hyperbaric chamber where pressured is increased. - Can reverse aging. - It's similar to hypoxia. So it's similar to exercise. Cold Therapy - Production of brown fat (burns white fat and enhances metabolism). - Cryotherapy, cold showers, sleep with few blankets. Heat - Saunas reduce 20% in cardiovascular disease. Let me know if you want me to keep posting these notes, I am on Twitter @juampiaranovich 105 Nora Nora 2 months ago Could you please, please, please do one episode talking about everything - supplements, fasting, cold and heat exposure and anything relevant for optimal health and longevity for women? As you have mentioned before there are differences and when you talk about these things and especially doses of supplements I think its for men. Pleaaaaaaase do one episode for women 🙏 260 Ujjwal Singh Ujjwal Singh 2 months ago (edited) -Have Low Levels Of Iron -Get Off Your Butt -Walk After Eating -Low Impact Excercise For 50 Minutes A Day 4000 Thousand Steps A Day (Walking, Running, Cycling) -Have A Hypoxic For Atleast 10 Min A Day; Recommendation: Do HIIT Or Vigorous Excercise 75 Min A Week -Bio-Tracking -Weight Training Maintain Muscle Mass Focus On Big Muscles -Hyperbaric Oxygen Therapy 90 Min A Day; Helps In Mimicking Excercise -Cold Exposure: Cold Shower Or Cryotherapy, Leave a Window Open While You Sleep, Put Fewer Clothes On And Move Out Specially In Winter, Etc. -Heat Exposure - Sauna Bathing Recommendation: Heat-Cold Contrast Shower Or Bath; 5 Or More Cycles 152 David Martínez Martínez David Martínez Martínez 2 months ago "We don't have to run from predators very often. And this is a real problem" - Dr David Sinclair I know it's completely out of context but I found it hilarious. 92 Robert Banks Robert Banks 2 months ago Hi, great info and presentation. I am 72 years young and every new person I meet, find it hard to believe that I am really that age. I am ex military and have maintained my fitness throughout my life by keeping flexible and using my lungs with purpose. From my Army days I have always finished off my shower with full cold water. In recent times I have been using the Wim Hof Method of breathing and cold showers and exercises. It has taken me to a new level of energy and well being. My only medical complaint is a hole in my esophagus from acid reflux. I have nearly always only eaten when hungry, and usually only enough to satisfy that hunger, knowing it will take 20 minutes or so to get that satisfaction. Being human, there have been times when this wasn’t always the case, but I am not fanatical about it. It feels great to be alive. 186 Denis Trebula Denis Trebula 2 months ago Another great podcast ! It would be amazing though, if Dr. Sinclair and Mr. Matthew LaPlante could take some questions and dedicate 2-5min segment to them, either from comment section or submitted upfront. Good job 👌! 171 Saptarshi Sarker Saptarshi Sarker 2 months ago This is the only series of podcast which I watch from starting to ending without skipping. Thank you David sir for all the knowledge 🙏🏻 122 Jaime L Jaime L 2 months ago I live in Ireland at the moment and now in middle of winter just going for an hour walk at 6am or evening is plenty cold therapy!😅 2 PSYBER PSYBER 2 months ago This is my favorite podcast, 2022 will be great 11 Steve NJ Steve NJ 2 months ago David...CHANGE THE BACKGROUND please!! Also you seem different (worse) in your podcast as compared as other podcasts you have been... maybe because you seem t-shirt laid back 😅 2 Janis Gailis Janis Gailis 2 months ago Dr. David, would it be possible to measure Biological Age from Europe? Please please make it happen. And if there is a chance for Inside tracker to provide full service for European market, would be amazing. Or any chance to cooperate with Inside tracker to open the European lab / center? 10 Abdul R Abdul R 2 months ago David Sinclair brother I have one question that no one seems to answer DOES water break your fast? What type of water breaks a fast? Bottle? Filtered ? I need to know 2 GM Kige GM Kige 2 months ago There is constant mention of eating less. What if you are thin from the start don't restricted feeding serve one better? Then again do you avoid foods like rice, flour and the likes of foods with high glycemic index? 4 Martin Martin 2 months ago How much iron is too much? What is the maximum level for Hemoglobin [g/dl] and Ferritin [ng/ml]? Which values are optimal (for an adult)? 3 Abood Cohen Abood Cohen 2 months ago (edited) What an exciting era to be alive thank you professor Sinclair! 91 Gina Van Ulzen Gina Van Ulzen 2 months ago As an Exercise Physiologist I applaud how accurate the exercise based information was! I did a little cheer when he said ‘no one type of exercise is the best’, because people are constantly saying there is a secret special exercise that fixes it all. 32 Aman Sharma Aman Sharma 2 months ago Perfect timing as I’m out walking in shorts and it’s the English winter 😂 5 Olivia Pos Olivia Pos 2 months ago Sinclair is only a few years younger than my parents and his skin has no signs of ageing in any photos and arguably looks younger than some photos on the internet from the past !?!? 2 ANGELA ELIZABETH MCCULLOUGH ANGELA ELIZABETH MCCULLOUGH 2 months ago Dr David, Do you have any advise/opinion/evidence on the effect of aromatase estrogen blockers when given as a 5 year post preventative treatment after mastectomy/breast cancer? .is there any protocols to offset this deficiency in women(as read women suffer huge age acceleration due to this)? Thank you… 6 Marco Peretta Marco Peretta 2 months ago Dr. Sinclair, What do you think about high calorie, high protein diets like the ones that are recommended for muscle building (hypertrophy) programs? For what I understand, you can't have that much calories overall in a single meal, but it's been proven to be effective on building muscle. Is it worth it to go that path if slowing down aging is your goal or it's actually not beneficial? 3 Hohmann Transfer Window Washer Hohmann Transfer Window Washer 2 months ago 3:48 Yasss!!! He gets it! I've made the same mistake when I was like 14 y.o. It was such a yucky chicken yellow-ish hue, omg. I cringe at the memories! But... I don't regret it, somehow. Kasia G Kasia G 2 months ago Question, do these things change (eating less, taking cold showers etc etc...) if you live somewhere that is already damp and cold? 2 elizabeth mallen elizabeth mallen 2 months ago Meditation reverses telomere damage as well! 2 클롸드 Klaude Vlog 클롸드 Klaude Vlog 2 months ago Reminds me of Huberman Lab. Another great channel! Thanks! 3 David Sinclair Courtkneeee Courtkneeee 2 months ago "Ill burn 10." Hahaha oh my god, I was dying after he said that 😂 Merlin Merlin 2 months ago (edited) I have been doing all this for years without knowing :) I ride my motorcycle in winter in the uk (cold) to the gym (exercise) then have a shower (heat) then back on the motorbike (cold). The motorbike also gets my heart pumping 11 אליאל בן-דן אליאל בן-דן 2 months ago Swim a mile every day, 50 minutes in a sauna, then five minutes in an ice cold shower. My energy levels and feeling of wellness go through the roof. 4 Cat Steinhilb Cat Steinhilb 2 months ago I’ve loved and learned from every single one of these so far ! I am so grateful to you both. I really feel there should be a Dr. Sinclair health class taught at every level of education! Starting now. 27 David Parker David Parker 2 months ago This channel is going to the Moon! I have watched every video and will watch every video. This information is more valuable then all the gold in the world! Thank you both for all you have done are continue to do. 57 David Sinclair Judyta Judyta 2 months ago Started with cold water at the end of the shower... will get there, comfort is such a trap! 3 Ramiro R Ramiro R 2 months ago OOOO MY GOD... I've been doing this for YEAR.. giving my stomach a break. Intermitted fasting for the past 24 year.. Im 53 in June and still in great shape. Thanks Dr. Sinclair.. Also im preparing for my MCAT, will be a Dr. soon myself.. 4 David Casey David Casey 2 months ago Love the podcast, I’ve listened to many podcasts, initially with Joe Rogan. I read the book as well. I started taking NMN and Resveratrol a year or so ago. Prior to taking the supplements I got a blood test and determined my internal clock with Inside Tracker, a couple years later I Re tested my blood and my internal clock reduced by 4 years. Amazing! 14 Alex Kits Alex Kits 2 months ago Dr. Sinclair is always interesting. One hour goes so fast 💨 and the topics are so amazing 🤩 5 Dave Whipp Dave Whipp 2 days ago Excellent information - thanks. However, as a "Hoffer" I would love to know David's opinion on the Wim Hof method esp his breathing exercises going from hyperventilaton through to the extended breath holding. Silja Niemistö Silja Niemistö 2 months ago Great podcast!!! ❤️ In case you could do Q&A in a future episode I'd love to know how pregnancy and breastfeeding affect ageing and whether the suggested protocols have been studied on pregnant and/or breastfeeding women. 9 Sanjar Shermat Sanjar Shermat 2 months ago There’s some serious bromance going on between these dudes! 1 Fred Winslow Fred Winslow 2 months ago (edited) She he said lovely I was certain he was talking about his wife or a lady guest. It’s perfectly unisex. But is Dr Sinclair gay? 1 Be Strong and Love Yourself Be Strong and Love Yourself 2 months ago I love this podcast so much! 🥰 I work out everyday, but I prefer short 15-20 minutes workouts and 20 minutes stretches, and it is hard for me to work out 1 hour at a time and then do stretches, I just don’t have time for that. So it is good to know that 15 minutes per day can be enough ☺️ Plus, I walk every morning for 30 minutes. I should be fine 😁 Thank you for making me feel good about my routine! 🙏❤️ 11 청ずらたん 청ずらたん 2 months ago I'm so happy for my grandkids that they will probably see the cure of aging happen in their lifetimes (maybe when they are my age). It's a huge system engineered with many odds and ends to kill us in the long term. A truely sad state of affairs. For my wife and I, it will come too late. It's all falling apart under our feet. Allowed to see the promised land, but we shall not enter it. It's alright though when you know that others continue. 2 lover lover 2 months ago "Move your ass to live happier and healthier"🙏 Thank you for this tremendous WORK! Nowadays - scientific knowledge is a real power Eric Chu Eric Chu 2 months ago "Help" by the Beatles is exactly what I picture Dr. David Sinclair would listen to! haha Brittany Storey Brittany Storey 2 months ago Hey thank you both for this PodCast! I am trying to make a new life long routine starting at 26. Can't wait to track myself. 21 Jimmy Cheung Jimmy Cheung 2 months ago Amazing to learn about the science behind Wim Hof's entire practice! 1 Arnaldur Björnsson Arnaldur Björnsson 2 months ago Premium quality content. Thank you so much Dr. Sinclair. Reading your book and listening to these podcasts has fundamentally changed the way I view human life and it's duration. 26 johnny roberts johnny roberts 2 months ago Hey doc , can’t you super oxygenate your blood with breathing methods , like used in Wim Hoff and others ? Seems like the results may be similar 🤷🏻‍♂️ 2 samsarah samsarah 2 months ago Watched this video while on my elliptical. The podcast sure kept me motivated!! 8 Esther Lihn Esther Lihn 2 months ago Dr. Sinclair you are awesome! Thank you for the insights, very pleasant to listen to. I've been learning a lot from you. Thank you for the free information! 21 David Sinclair rickyu1978 rickyu1978 2 months ago "ill burn 10" 😂 38:38 Wednes Day Wednes Day 2 months ago That intro is just so beautiful chef's kiss 1 Captain Pike Captain Pike 2 months ago David is one of THE best science on the level understandable to the layman - 4 Ligia Sommers Ligia Sommers 2 months ago (edited) I wait for this podcast as my favorite one 🙏🏻✨🌹⭐️⭐️⭐️⭐️⭐️ps: I take AGreens and love it 🥰 1 Natalie Axl Natalie Axl 2 months ago Anti-aging and Longevity is Priceless!! Never stop investing in yourself. THANK YOU DAVID 😊 💓 5 Jimmy Essien Jimmy Essien 2 months ago Excellent episode. However, I was a bit disappointed that there wasn't much talk about saunas 😅 2 Lucas Mark Lucas Mark 2 months ago When it comes to the world of investing, most people don't know where to start. Fortunately, great investors of the past and present can provide us with guidance 💯 38 The BroSirs The BroSirs 2 months ago "So your average person will burn 20 calories, I'll burn 10..." 😀 Kate Alvo Kate Alvo 2 months ago Thank you for this amazing information! I was wondering if you had any information regarding using Breathwork such as the Wim Hof method or Buteyko breathing to induce hypoxia. Is the hyperventilation / hypoventilation we see in Wim Hof doing the same thing as the Hyperbaric chamber you mentioned, due to the large differential created during the practice? Thanks again! 3 二零二一年十二月 二零二一年十二月 2 months ago (edited) Your voice is full of life…… And I’m the queen of England. Lmao 🤣 The Path of Eudaimonia The Path of Eudaimonia 2 months ago One of the few channels/podcasts I am eagerly waiting for the next episode! 6 TheBladeMasterOfLove TheBladeMasterOfLove 2 months ago Why do you look so disappointed? We love you, David and co-host! 2 Bartosz Ulkowski Tattoo Bartosz Ulkowski Tattoo 2 months ago i am waiting for next episodes as i am waiting for A PREMIERE of a NEW MOVIE!!!! 2 Rich Finaldi Rich Finaldi 2 months ago I love this podcast and everything about staying young as long as possible , but I thought of something recently , I would NEVER want to live as long and outlive everyone I love , nope , especially my wife and daughter , mortality has many wisdoms , and "everything that has a beginning has an end" As Agent Smith Said in the Matrix lol , Watch the green mile , tom hanks in that movie his character lived to 108 and was still going he outlived everyone he loved , and it was sad , BUT all being said the way I live is not to die, the way I live is dying to live 4 DJ Rampage DJ Rampage 2 months ago I just spent 4 hours learning how the mitochondria works because of this amazing episode ... Life is bazar. Thank you David & Matthew! 17 Vera Arena Vera Arena 2 months ago Excelent podcast, two intelligent brains, fantastic educative and pleasant discussion of very important health issues! Thank you!! 6 Dr. Sammy Pryor Dr. Sammy Pryor 1 month ago Haha, Matthew LaPlante said, "I would burn 10." A little self-deprecating humor! Silh S Silh S 2 months ago 3:50 🍊😪🍊😂😂 the things we do during quarantine ! Eric Wiese Eric Wiese 2 months ago Dr. Sinclair thank you for your information. Loving the podcast too. 5 jules153 jules153 2 months ago Does "cold" have to be actually cold or just relative? For example if you live in the Middle East with no air conditioning even a 20degC bath would seem very cold, where as a resident of Alaska would thing the same 20degC bath to be quite warm I'd think..... 3 Axolotl Axolotl 2 months ago 9:58 David belike: Yeah!, I am just a highschool biology teacher Pit Bull Pit Bull 2 months ago (edited) HA HA HA ..."I'LL BURN 10" CALORIES .... LOL LOL LOL 1 Swamp Hawk Swamp Hawk 2 months ago "Free radicals" in portland oregon. haha, I love it. Based. Josh Prowse Josh Prowse 2 months ago "I'll burn 10." Nice. Tom Olofsson Tom Olofsson 2 months ago We get our annual dose of cold in Chicago. 2 Kylie Buschgens Kylie Buschgens 2 months ago Love these podcasts but…. OMG I want a little, cold, dwarf mouse for my friend 🐭 Lisa Falanga Lisa Falanga 2 months ago At 57 & 1/2…I am making progress❣️Blessings to you, Dr. Sinclair..Staying close to your podcast, Here, Lake Tahoe, NV🏔 6 Kinga Korska Kinga Korska 2 months ago Non-substantial side note: the intro to this podcast reminds me of Monty Python's "It's the mind" 🤓 Biff Tannen Biff Tannen 2 months ago G'day Dave! Anxiously awaiting breakthroughs in glaucoma treatment, mate! Full speed ahead ay? Pit Bull Pit Bull 2 months ago LOVE THE RAIDERS HAT HELL YEAH ! 1 David Kim David Kim 2 months ago Thank you sir for these amazing podcasts !!!! :) 2 David Sinclair Esra Malakasis Esra Malakasis 2 months ago This discussion is so satisfying. This science is insanely interesting 🚀I want to turn on all the good turn off all the bad. I’m getting my lab work with inside tracker in the morning! Thank you for sharing 1 Faisal G Faisal G 2 months ago Man loves to trademark everything 1 Lar Lar 2 months ago (edited) I wish this other guy would stop feeling the need to throw in his 2 cents and just let Dr Sinclair speak. 1 Ja Or Ja Or 2 months ago Physical Activity and Senescent Cells 47:50 --- You mentioned there would be a link to an article in Aging Cell about physical activity and removal of senescent cells. Do you have time to point that out? I don't see the link. 1 Wayne Cutler Wayne Cutler 2 months ago You're amazing, thank you for all you do :) 5 Andres Pinzon Andres Pinzon 2 months ago (edited) Hi David! Great podcast, I have been following your work for years. On the other hand, having a standing desk injured me. I was standing half of the time and my foot got injured. I recommend doing 5 minute active pauses each hour instead 5 Qeva Qeva 2 months ago Watching your great Podcast while smoking 😹 1 Claudia Fernandez Claudia Fernandez 2 months ago Dr Sinclair, Thank you for the time and dedication to share this valuable information. I appreciate it. 7 Daddy Dustin Miller Daddy Dustin Miller 2 months ago Subscribed before 1.2 seconds in to the Ad. 1 A. Blake Throne A. Blake Throne 2 months ago Sinclair, you mentioned you take your AG1 in the morning does that break your fast?? Brook Ma Chatte Brook Ma Chatte 2 months ago (edited) Shoutout Eugene, OR lol 1 Captain Tennille Captain Tennille 2 months ago (edited) Ooof, I lost over half my hair 3 months after having Delta. It’s finally starting to grow back but I lost so much. So overwhelming. They are calling 2021 The Year Americas Hair Fell Out. Maybe do a cast on the Covid hair loss? There’s a yoububer who is losing hair 17 months after just losing her smell and taste a few days. It’s insane. Feels like radiation sickness. My Thyroid test came back normal but I am always iron and D deficient no matter what I do it seems. There are articles all over the internet about Covid hair loss. I’m not on Fb but a lot of my friends and family are coming to me telling me more and more they are seeing people sharing about their Covid hair loss experience. It’s becoming a sort of an epidemic of its own. 😣 not fun at all. I went from my hair very thick and long to filling the toilet every day for almost two months. I’ve heard of plumbers posting about pulling wads of hair out of the septic lines from Covid hair loss. It’s no joke. Bless. 2 Kunal Singh Rathore Kunal Singh Rathore 2 months ago Here we go.. after listening to the entire episode3 on Spotify 2 hours ago..waited for this here..One more time.. Cheers to taking another step towards a better future for humans evolution 8 Connor L Connor L 2 months ago 35:55 My BMW will last forever *after 11 years 450.000 km - Next stop 1.000.000 *but there is a secret ... Graf video, btw Hailey Nichelle Hailey Nichelle 2 months ago Thank you! Could you review various sleep devices (like Oura, Fitbit, etc.) and rank them by accuracy/comfort/value? cjcj2010 cjcj2010 2 months ago (edited) Funny, i let my daughter bleach my hair early on in the "pandemic." It turns orange after only a few washes after coloring. Using Surya Cream Henna. Really easy on the hair. Your hair looks natural from here. Thanks for all of the info! kennylo8423 kennylo8423 2 months ago Can't get enough DR! THANK YOU! YOU ARE CHANGIN LIVES ! 1 Aloha Grace Aloha Grace 2 months ago Get off your ass!🔥❤️‍🔥🔥 62 and loving life. I gave up driving in 1998 and choose to live within 2 miles from where I work. I ride my beach cruiser bike and walk everywhere. I am always amazed how people tell me those are strange choices, yet clearly they are healthy choices. I look far younger than most my age, but more importantly, I feel younger. Your health is your wealth. We must take accountability for our own health and happiness. Love this podcast. I did a lot of intermittent fasting in my youth, not understanding how healthy it was for me, I only knew I felt better while doing it. Thanks for explaining it all here. Andrew Fortin Andrew Fortin 2 months ago Information like this should be spread to the masses. Thank you for your hard work & research! 2 Cenot4ph Cenot4ph 2 months ago (edited) Not mentioning The Iceman when it's about cold therapy is a missed opportunity 1 Shaktinath Poudyal Shaktinath Poudyal 2 months ago love watching this channel, please some light on hair fall and baldness. 1 Sally Griffen Sally Griffen 2 months ago HOW MUCH TIME PER DAY AND PER WEEK ON THE 3RD PART - MUSCLE BUILDING? 1 Natasha Kharitonova Natasha Kharitonova 2 months ago Sooooo does it mean that breathing using Buteiko method should in theory bring the same benefits as the exercise (in terms of bringing on the hypoxia)? 2 robert towner robert towner 2 months ago man this podcast is very good. looking foward for the next ones. subbed 1 Dr. Brad Shook Dr. Brad Shook 2 months ago Amazing work! I really appreciate the sharing of your knowledge and time. 5 Explorers of the World Explorers of the World 1 month ago thank you for very valuable and useful knowledge, I would be interested in the topic of fertility in women, how to care for it and whether it can be kept J B J B 2 months ago I have to know how much Dr. Sinclair deadlifts!! Do tell!! Eric Mikkelsen, LMFT Eric Mikkelsen, LMFT 2 months ago Do glad you're continuing to keep us up to date! Thank you so much! Could you please put together a terminology glossary that could be understood by a lay person not in your field. 1 Lisa Love Lisa Love 2 months ago (edited) You're very cute David Sinclair!!! Your practices and research all look good on you! I am following your advice so I can be the same in my 50's. You are impressive on many levels. James Kirkland James Kirkland 2 months ago Great podcast. Would love to hear some commentary on how protocols and methodology changes for those that haven't started "getting old" yet 8 JohnnyBravos JohnnyBravos 2 months ago (edited) hahaha What a Bozo! He suggests paying for hyperbaric chamber where you would watch tv while mimicing exercise, and he finds cold showers unpleasant!!! 1 Sherry Boxall Sherry Boxall 2 months ago Wed morning is my fav time of the wk! Thank you❤ I'd love to hear re reputable supplements. Im having a very hard time finding a good source of reservatrol 2 David Vergel David Vergel 2 months ago I loved the Portland Oregon joke at the beginning 😂 L'amour Alice L'amour Alice 1 month ago omg hypoxia actually is something that I am feeling it myself that's works! Thank you so much for bring this up💜, I really feel that have a lot to do with qi kung and hydrogen related benefits! So grateful for all this boardcast！ BoydyGuns BoydyGuns 2 months ago If high iron levels in the body is associated with early death, then would giving blood 1/2/3 times a year be beneficial to longevity?? 4 BeeBop Gaming BeeBop Gaming 1 month ago “I don’t eat breakfast or lunch, and I just focus on dinner”. 20 seconds later…. “I drink this product every morning” lol. Make that money my dude. 😂 Geoff Malone Geoff Malone 1 month ago Good afternoon Dr Sinclair, First let me say I loved your book and I am finding your podcasts amazing. My question is: lots of people say stressing your body is so good for you for several reasons, heat, cold, hunger etc. But no-one mentions if dehydration can benefit you? disease /health /diets disease /health /diets 2 months ago Thank u so much! dr David sinclair .. Ur all episodes so amazing which giving us deep knowledge for long life..sir! i want to know that all human cells made by DNA, it synthesise due to many important molecules,Such as aminoacids minerals.. But is oxygen more imp. than other for long life cell.. Lord of T Lord of T 2 months ago Love 1 Keith DeFiebre Keith DeFiebre 2 months ago I like it when you do the advertising - business regarding the sponsors of your podcast, and your eyes lock into the wording as you read the data and the stare forward and the eyes look all serious and locked into each letter. As you talk about getting younger as you take trips around the sun! My mindset too 👍👍 Isabelle Ebel Isabelle Ebel 2 months ago Dear Dr. Sinclair, this podcast is amazing ! Thank you so much for your time and dedication! What a hightlight of the week! Unfortunately, the link to levels does not seem to work, would you be able to provide us with the right one? Thank you! 5 Roberto Benedit Roberto Benedit 2 months ago this is so truth, love it saxon gregory saxon gregory 2 months ago (edited) I really want to know what your thoughts are on ghrelin suppressants would you recommend people take them? 3 HeartHugz HeartHugz 2 months ago As someone who lives in Eugene Oregon, I laughed out loud, hard on your comment about free radicals! 😂 Abdul Rabbani Abdul Rabbani 2 months ago Great episode, I was looking forward to this episode all week! I usually watch all podcasts at 1.5x but I watched this at 1x so I could enjoy it longer :D 4 Md Habi Md Habi 2 months ago Thank you so much, this is a lifesaver . Chris Upcroft Chris Upcroft 2 months ago It is crazy anyone can come and get this information for free!!!! Thanks so much for putting these together. 1 Dan Guidi Dan Guidi 2 months ago Imagine having to be the finish carpenter in that room, so many damn corners... Maximillian Lundin Maximillian Lundin 2 months ago Hi Dr Sinclair Amazing podcast, thank you for sharing this 👍 Question: What can you expect in muscle gains if you are staying within a healthy level of protein intake per day (all plantbased) with regards to not increase mTOR causing faster aging. Is there a threshold of % calories of total daily requirement that can come from protein? I eat 2 wholefood meals per day and one smoothie in between with different wholefoods and plant proteins. Is the level of concentration of amino acids activating mTOR more important than if they are plantbased or animal based? Background to question: 2 months ago I started fasting on 14/10 regiment. Past 2 weeks I scaled up to 16/8 and intend to stay there. Taking the science of hypertrophy from Dr Andy Gaulpin, the need for protein is higher than normal which makes it hard to have a 8h feeding window and reach the levels of adequate protein. I'm thinking that there is a framework/limit for muscle gain per individual person that is regulated by how much exercise you can get in during a week and how many calories you can eat and how many of those calories can come from protein. Plus some genetics. Thank you again // Max 1 Elizabeth Rider Elizabeth Rider 2 months ago Great episode! Looking forward to the next one 😀 1 martin stephenson martin stephenson 2 months ago This really really outstanding. Naturally with David Sinclair. Covering so much ground in a little over an hour is so useful. I think the 1 hour podcast will become the new standard. 1 Park SuMin Park SuMin 2 months ago (edited) Very thankful for this video from Korea. I also would like to know more on relationship between sleep and longevity through the view of Dr. Singlair ! 2 Jawad Karim Jawad Karim 2 months ago (edited) Professor David Sinclair, I just salute you from my Heart..... 1 B T B T 2 months ago It's great to finally have interesting things to watch and listen to. Mainstream TV and BBC radio only hits the average iq. With this, I am pressing rewind and writing things down, looking up and listening again. Thank you. 1 Victor Affaro Victor Affaro 2 months ago How amazing it is to have all this info direct from the fount and for free. Thanks a lot Emilio V Emilio V 2 weeks ago this is insane. I love this podcast jules lloyd jules lloyd 2 months ago I’d be interested to know if there are benefits to starting this at a younger age say before 30 or if you still get the same benefits starting after 30? 5 Will Green Will Green 2 months ago Please podcast with Leo and Longevity 2 Bilbo Baggins Bilbo Baggins 2 months ago Thank you Sinclair! Hope you don't succumb to the jabs you've taken. Faith MacWatters Faith MacWatters 2 months ago I recently found you, talking to Tim Billyeu, fascinating stuff! I will be an inspired lifetime follower for sure!!!! I would like to clarify. Piriformis, is the biggest of a group of four muscles, the lateral hip rotaters. Of which only the obturator externus travels threw the hole in the pelvic bone. The other stay more superficial. Fyi... Gabriela Madorno Gabriela Madorno 2 months ago I have been supplementing with zinc forever. After listening to you I will stop, but how can I get rid of the excess zinc in my body? 2 Chrispys Camping Adventures Chrispys Camping Adventures 2 months ago (edited) This is an excellent podcast. Really enjoying the episodes 3 Midhun Arja Midhun Arja 2 months ago Been following you since your episode in Tom Bilyue's show. The way you explain things in awesome. Thank you for sharing your knowledge. rebaked rebaked 2 months ago Amazing series. Can't wait for the next episode 2 Marina Foglietti Marina Foglietti 2 months ago Thank you a lot for all these interesting informations. I have began to assume Reveratrol, I practise sport at home for 20/30 minutes three times a week in the afternoon; sometimes I go out for walking, not all days, but I never stop moving at home. I wait for the next post.😍😍😍🇮🇪 Peter Peter 2 months ago Thanks! Question: what form of iron? Ferritin? Optimum range? This is rarely measured and is not on basic CBC panel as plasma iron is. 2 Wileydj Wileydj 2 months ago Hey... you called out my town in Oregon. Cheers. Alex Gordin Alex Gordin 2 months ago Hi David and team, thank you so much for this podcast. It’s great! Do you think that recreational diving with nitrox (oxygen enriched air with 32-36 percent oxygen) will have an effect similar to oxygen hyperbaric therapy? 1 chris tinley chris tinley 2 months ago Im all ready addicted to all the wonderful info you both have here!! Keep up the great science guys!!:) 1 Farzin Solaimani Farzin Solaimani 1 month ago Thank you David Sinclair Bicycle Seat Thoughts Bicycle Seat Thoughts 2 months ago Absolutely love this channel. Reading the book, been listening to every podcast and you tube video since last May. Taking some of the supplements and at 46, I have noticed a difference. Thank you! This is the best thing to listen to while you walk you dog, folks. 3