PhenoAge and the Epigenetics of Age Acceleration — can we change the pace?

#Aging #EpigeneticClocks #TrueAge Morgan Levine, PhD, on PhenoAge and the Epigenetics of Age Acceleration — can we change the pace? 40,443 viewsPremiered Apr 12, 2022 FoundMyFitness 413K subscribers Morgan Levine, Ph.D., developed the phenotypic aging clock called PhenoAge and is a Founding Principal Investigator at Altos Labs, a biotech company that seeks to understand the mechanisms that drive the aging process and age-related diseases with the hope of identifying possible interventions. Additionally, Dr. Levine is an assistant professor of pathology at the Yale University School of Medicine, where her research focuses on the science of biological aging. Dr. Levine completed a postdoctoral fellowship with previous guest Dr. Steve Horvath, a pioneer in the field of epigenetic clocks. Show notes and transcript available: https://www.foundmyfitness.com/episod... Pre-order Dr. Morgan Levine's new book True Age: https://www.amazon.com/True-Age-Cutti... CHAPTERS: 00:01:19 - What is aging? 00:03:20 - Why biological aging matters to scientists 00:04:45 - Hallmarks of aging 00:05:24 - What are the drivers of aging? 00:06:58 - What CpG methylation says about aging 00:08:59 - The advantage of epigenetic clocks in research 00:10:12 - New generation epigenetic clocks: GrimAge and PhenoAge 00:11:51 - Clinical biomarkers vs. epigenetic clocks 00:12:50 - Differences in aging between organ systems 00:16:47 - Do some people age faster than others? 00:19:05 - Epigenetic age acceleration 00:20:39 - Is age acceleration a genetic risk inherited from your parents? 00:22:27 - The effects of menopause on aging 00:23:16 - Does the pace of epigenetic aging change throughout life? 00:24:39 - How does obesity and human disease affect epigenetic aging? 00:26:12 - Why genes from development may be key to understanding aging 00:27:13 - Determining epigenetic age in non-human mammals (all of them) 00:27:50 - Is aging an accident of evolution or by design? (See also 00:48:20) 00:30:17 - What happens to the epigenetic age of immortal cells if you grow them forever? 00:31:40 - Effects of cancer treatment on epigenetic age 00:35:43 - Severe COVID-19 and accelerated epigenetic 00:36:40 - Are epigenetic changes in aging a cause or consequence? 00:39:23 - Are the CpG sites used by epigenetic clocks functionally meaningful? 00:42:15 - Reversing epigenetic age with interrupted reprogramming techniques 00:49:27 - Therapeutic plasma exchange in aging and pro-geronic blood factors 00:53:23 - The effects of neutral plasma exchange on the brain 00:56:01 - Lifestyle factors that accelerate epigenetic age 00:57:56 - The aging acceleration effect of smoking 00:59:37 - Omega-3 hypermethylation of inflammatory pathways 01:03:23 - Reliability of consumer epigenetic clock tests 01:06:12 - Construct validity of epigenetic clocks 01:12:06 - Thoughts on most exciting research in aging field 01:13:44 - Dr. Morgan Levine's lifestyle habits 01:15:00 - Intermittent fasting effects on epigenetic age Dr. Morgan Levine on Instagram: https://www.instagram.com/dr.morganle... Dr. Morgan Levine on Twitter: https://www.twitter.com/drmorganlevine Dr. Rhonda Patrick on Instagram: https://www.instagram.com/foundmyfitness Dr. Rhonda Patrick on Twitter: https://www.twitter.com/foundmyfitness SUBSCRIBE TO THE FOUNDMYFITNESS YOUTUBE CHANNEL: https://www.youtube.com/user/FoundMyF... Get notified of new videos by hitting the bell icon. This episode is available as a podcast on Apple Podcasts and Spotify: https://podcasts.apple.com/us/podcast... Listen to FoundMyFitness on Spotify: https://open.spotify.com/show/5QjpaU0... Premium subscribers of FoundMyFitness get access to a Google Presentation for the graphics in videos, earlier access, a two-times-per-month science news digest and commentary, and some kind of live online event usually every month. Learn more at: https://www.foundmyfitness.com/crowds... #Aging #EpigeneticClocks #TrueAge 125 Comments rongmaw lin Add a comment... FoundMyFitness Pinned by FoundMyFitness FoundMyFitness 10 days ago (edited) Find Dr. Levine's new book True Age on Amazon! If you enjoy the material we produce, please consider liking, sharing, and subscribing with notifications. We develop the extra resources provided with each episode through the support of our premium members. Learn how to get exclusive bonus content and other added perks here: https://www.foundmyfitness.com/crowdsponsor True Age: Cutting-Edge Research to Help Turn Back the Clock." You can pre-order it on Amazon now: https://www.amazon.com/True-Age-Cutting-Edge-Research-Clock/dp/0593329287 10 RWH RWH 9 days ago I appreciate Morgan's no nonsense approach. Everybody wants to hear there is a quick fix but she serves up the truth as she sees it. 9 FoundMyFitness Taylor Libby Taylor Libby 10 days ago I always have to lisren to these discussions from Dr Patrick at least twice to make sure my dumb brain gets a glimpse of the knowledge.😂🤣 38 Cheryl R Leigh Cheryl R Leigh 8 days ago CHAPTERS: (from Dr. Patrick's description box) 00:01:19 - What is aging? 00:03:20 - Why biological aging matters to scientists 00:04:45 - Hallmarks of aging 00:05:24 - What are the drivers of aging? 00:06:58 - What CpG methylation says about aging 00:08:59 - The advantage of epigenetic clocks in research 00:10:12 - New generation epigenetic clocks: GrimAge and PhenoAge 00:11:51 - Clinical biomarkers vs. epigenetic clocks 00:12:50 - Differences in aging between organ systems 00:16:47 - Do some people age faster than others? 00:19:05 - Epigenetic age acceleration 00:20:39 - Is age acceleration a genetic risk inherited from your parents? 00:22:27 - The effects of menopause on aging 00:23:16 - Does the pace of epigenetic aging change throughout life? 00:24:39 - How does obesity and human disease affect epigenetic aging? 00:26:12 - Why genes from development may be key to understanding aging 00:27:13 - Determining epigenetic age in non-human mammals (all of them) 00:27:50 - Is aging an accident of evolution or by design? (See also 00:48:20) 00:30:17 - What happens to the epigenetic age of immortal cells if you grow them forever? 00:31:40 - Effects of cancer treatment on epigenetic age 00:35:43 - Severe COVID-19 and accelerated epigenetic 00:36:40 - Are epigenetic changes in aging a cause or consequence? 00:39:23 - Are the CpG sites used by epigenetic clocks functionally meaningful? 00:42:15 - Reversing epigenetic age with interrupted reprogramming techniques 00:49:27 - Therapeutic plasma exchange in aging and pro-geronic blood factors 00:53:23 - The effects of neutral plasma exchange on the brain 00:56:01 - Lifestyle factors that accelerate epigenetic age 00:57:56 - The aging acceleration effect of smoking 00:59:37 - Omega-3 hypermethylation of inflammatory pathways 01:03:23 - Reliability of consumer epigenetic clock tests 01:06:12 - Construct validity of epigenetic clocks 01:12:06 - Thoughts on most exciting research in aging field 01:13:44 - Dr. Morgan Levine's lifestyle habits 01:15:00 - Intermittent fasting effects on epigenetic age 9 Cody Johnson Cody Johnson 8 days ago Listening to these podcasts always makes me want to go back to college for biomedical engineering. 7 FoundMyFitness Robert Anderson Robert Anderson 9 days ago Another brilliant upload. Although I amazed that most people don't realise there is difference between chronological age and biological age. 8 FoundMyFitness Joe Schmoe Joe Schmoe 10 days ago So thankful Rhonda! Life-changing information - for free! Such a public good. Science educators have no idea how much they impact the population. Truth is the greatest medicine. 4 FoundMyFitness Stealth Machines Stealth Machines 10 days ago I need like 10 times on repeat with these intellectuals...always educational!!! N fun!! 9 FoundMyFitness T D T D 10 days ago Thanks, as always, Dr Patrick... a gift. 12 FoundMyFitness Aldraz Aldraz 6 days ago This was really great and informative talk! Stuart Berkowitz Stuart Berkowitz 10 days ago Would cell free dna tests like Grail allow us to capture fragments of dna from various tissues with high specificity (~90%), and at the same time allow epigentic aging by tissue type if enough fragments from each tissue are captured? Obi z Obi z 10 days ago (edited) I use Morgan Levine's PhenoAge to track the impact of my diet. Interestgly, I did slightly better on a vegan + sardines + yogurt + cheese diet than I did on a vegan + sardines diet. 9 FoundMyFitness Bruce Hutchinson Bruce Hutchinson 10 days ago (edited) Discovering and listening to Dr Patrick on Joe Rogan's podcast was the beginning of me learning about nutrition getting off the SAD= standard American diet. And thus going down all the rabbit holes I have found -- many Physicians, physician researchers and researchers about diet nutrition 3 FoundMyFitness A W A W 9 days ago Grateful for this knowledge and these strong and skilled women! FoundMyFitness Krissi Berry Krissi Berry 10 days ago HCG treatments are currently used to reverse inflammation. How does this affect epigenetics in cells? 3 Leonard M Leonard M 6 days ago Great information as always. 👍 Sean Byrne Sean Byrne 10 days ago Much looking forward to this discussion! 1 Bruce Hutchinson Bruce Hutchinson 10 days ago Discovering and listening to Dr Patrick on Joe Rogan's podcast wasted beginning of me learning about nutrition getting off the standard American diet. And this going down all the rabbit holes I have found hope Physicians physician researchers and researchers about diet nutrition Orange Banana Orange Banana 8 days ago If there is ANYONE talking about longevity and aging, this is the woman to listen to; leading by example. Brilliant podcast! FoundMyFitness NML NML 10 days ago Thank you so much! So interesting! FoundMyFitness Martin Tippins Martin Tippins 1 day ago She said "there is no one cause of aging" but different species live very different life spans. Dogs and cats live only 20 years or so and parrots live to 90. So in my view there must be a genetic clock and we should be able to switch it off. I'll definitely subscribe if you can switch my clock off. beepbeepnj beepbeepnj 9 days ago George Burns on his 100th birthday speech with typical martini and cigar in hand told the audience, "If I knew I was going to live this long, I would have taken better care of myself." 5 Rayana Keita Rayana Keita 9 days ago Smart ppl beautiful inspiring women amazing podcast informative talk just love this channel FoundMyFitness Angelic Annihilator Angelic Annihilator 9 days ago (edited) She is the perfect spokesperson for longevity research, she looks amazing and she's super smart :) 2 Melkiyad Melkiyad 10 days ago Amazing info :3 thank you for this 1 Melkiyad Melkiyad 10 days ago What a great format update! 1 FoundMyFitness The Al Stewart Archives The Al Stewart Archives 9 days ago (edited) So what are the actionable steps regarding optimising one's Omega 3 index? I eat Salmon twice a week, flaxseeds daily, but take no Omega 3 supplements - should I be getting blood work and supplementing based on the results in the same way I do with Vit D? - David Ruthу Robbins Ruthу Robbins 4 days ago ❤️ Hermosa eleccion 4.FO/elizeid de mejor 1 (elecciones ) 9.9/10 2 ( culturales ) 9.7/10 Son unos de los mejores conciertos , no-puede-ir-pero-de-tan-solo verlos desde pantalla,, se que estuvo Sorprendente . LUNGSlikeKlRBY LUNGSlikeKlRBY 11 days ago Love it! 2 FoundMyFitness Larry Kraft Larry Kraft 8 days ago @FoundMyFitness, Thought you might enjoy knowing that I first heard of Joe Rogan as a result of taking in as much as I could find of your content here and on FoundMyFitness. Keep up the good work! FoundMyFitness UHFStation1 UHFStation1 7 days ago I hope we find something that reverses aging without drastically changing lifestyles aside from not smoking and bad habits like that. I don't think fasting all the time is for most people. youtuber42 youtuber42 5 days ago Any studies on GrimAge comparing long term diet effects? e.g. on long term low-carbers? William Dias William Dias 10 days ago Two beautiful and very intelligent woman talking about one of my favorite subjects , this one is going to be great !! 5 Barre86 Barre86 10 days ago This woman is going to be a super super super centinarian Jojo Jojo 10 days ago Mitochondria is the powerhouse of the cell. 1 aa bbb aa bbb 7 days ago (edited) Great podcast but the point ultimately becomes what does all this effort actually accomplish? Through not overeating and exercise alone you are getting the lions share of the benefits. Everything else seems like noise, including intermittent fasting, which is not even reproducible beyond mice data so far. The obsession is just a waste of time 3 Kj Jacobs Kj Jacobs 11 days ago With all due respect Dr Rhonda please try to shed light on the livers ability to heal cells by sending out photochemical compounds attached to amino acids and antioxidants to seek and heal the cell instead of only researching the cell. We fully get it oxidative stress is bad and antioxidants are good but the liver needs some light shed on it’s more than 2000 chemical compounds Yes 2000 not 500 3 ChessMasterNate ChessMasterNate 7 days ago I watch everything double speed, even this, and I understood everything...I think...except...where the floor ends and the wall begins. 1 Yuval Kapellner Yuval Kapellner 4 days ago (edited) You mentioned women epigenetic age being younger than man with same chronological age assuming similar lifestyle is adopted with women and as long as they get their period this stays consistent. Later you talked about the current hot topic which is young and old plasma exchange or even dillution which shows rejuvenation effect. Well, thete is a relationship here- women age is affected by their period since they lose blood which helps with rejuvenation procedures forced by the body. Now, most likely this could be observed just by drawing blood from men once a month for some time to validate the same. That is why prp treatment which is often used as hair growth catalyst or wound healing could also have this side effect on aging in a positive manner. Especially when done repetitively every x time. Some data suggests that there is a negative over accumulation of iron in aging blood and removing some of it enables rejuvenation to take effect Krissi Berry Krissi Berry 10 days ago Any studies on epigenetic age reversal? 4 DjProjectus DjProjectus 5 days ago WRhongda, Bart Kay did a very good video on your opinion expressed on Joe Rogan interview about the carnivore diet! 1 silverhranch silverhranch 10 days ago Hey Dr.Patrick, what do you put on your skin that makes it shine so much? vindictii vindictii 10 days ago Damn, Dr. Levine looks like she has already reversed her aging 3 StarKiller StarKiller 8 days ago Using a sunua and being in a fasted state before a Biological age test sounds like a good trick to cheat the results :) Annuar Zirene Annuar Zirene 7 days ago 🙏🙌 Jason Guay Jason Guay 9 days ago Why are you not on Spotify as well? I will talk to them about offering you a deal! This is life-changing information. eric sevyn eric sevyn 7 days ago Great conversation. It would be even better if longevity researches like this would stop saying plant based diets are better for longevity. This is an archaic notion regarding mtor stimulation. Dig a little deeper please. Betsy Westbrook Betsy Westbrook 10 days ago My mom got double pneumonia at 16 they read her the last rites. TB at 17 relapse at 36 cancer at 54 cancer again at 78. She is now 93 and going strong so I am not sure where disease is predictive of other serious illness shortening lifespan? 6 Nuke Laloosh Nuke Laloosh 9 days ago and this one time, at age acceleration camp Bob Bobson Bob Bobson 10 days ago Where can we get a GrimAge test?? Justin P Justin P 10 days ago Just wondering - how old is Morgan Levine? 1 spine1955 spine1955 1 day ago Poor Audio for YouTube. Please use better mics. Thanks, Katana Katana 10 days ago Some folks age like milk. Menstrel Menstrel 11 days ago You only have to look at the English to realize that some people age in an accelerated fashion. 4 dlb dlb dlb dlb 10 days ago Unless you can can change the epigenic clock all you are doing is looking at the speedometer. Augusto Semplice Augusto Semplice 10 days ago May I pay a compliment? Very smart and attractive Ladies indeed. :) Bryan Interlaken Bryan Interlaken 4 days ago Yeah, good luck with your plant based diets. lol Emily Stornetta Emily Stornetta 6 days ago Genetics are only 10-20%...then why is the most significant predictor of your lifespan how long your parents lived? Henley JJ Henley JJ 1 day ago mRNA vaccines and epigenetic aging? Emily Stornetta Emily Stornetta 6 days ago Plant based...ugh. Not great if you are trying to drive protein synthesis or mostly trying to be low carb. Works for her as a very slender woman, not for a man that is trying to be muscular. Earwaxfire909 Earwaxfire909 10 days ago What do longer lifespan animals have that differs from shorter lifespan animals? thejackocat thejackocat 10 days ago Good content, of what I could hear. Stop mumbling please 2 Annuar Zirene Annuar Zirene 7 days ago