The Science Behind Why We Age | Lifespan with Dr. David Sinclair #1

Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks. #Aging #DavidSinclair #Longevity Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsincla... Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclai... Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introduction 00:03:14 Goal of the Lifespan Podcast 00:07:11 Acknowledgement of Sponsors 00:10:45 Aging is a Controllable Process that can be Slowed & Reversed 00:16:42 Organisms with Extreme Longevity 00:21:47 Genes that Regulate Aging: mTOR, AMPK, Sirtuins 00:21:55 mTOR & Rapamycin 00:24:33 AMP-activated protein kinase (AMPK) & Metformin 00:30:57 Sirtuin Proteins as Epigenetic Regulators of Aging 00:35:33 Ex-Differentiation 00:43:30 Measuring Aging - Biological Age vs. Chronological Age 00:49:30 "No Law That Says We Have To Age" 00:50:33 Episode Summary & Key Takeaways - Why Do We Age? 00:54:00 Information Theory of Aging 00:57:59 Aging is a Medical Condition 01:01:00 Aging Myths - Telomeres & Antioxidants 01:01:55 Options for Subscription and Support Links: Weapon fragments in bowhead whales - https://bit.ly/3eP7rqP Rapamycin extends lifespan in mice - https://go.nature.com/3F0yud3 Targeting Aging with Metformin (TAME) Trial - https://bit.ly/3eU9ABk Metformin improves healthspan and lifespan in mice - https://go.nature.com/3JSRZbs Metformin reduces all-cause mortality - https://bit.ly/3pWNiWc Reprogramming to restore vision - https://go.nature.com/335iysI DNA methylation age - https://bit.ly/3sUAUYB Genome-wide methylation profiles & human aging rates - https://bit.ly/3ETPXnK Reversal of epigenetic aging in humans - https://bit.ly/3eUior3 Danish twins study - https://bit.ly/3eToU13 Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Chapters Introduction 0:00 Goal of the Lifespan Podcast 3:14 Acknowledgement of Sponsors 7:11 Aging is a Controllable Process that can be Slowed & Reversed 10:45 Organisms with Extreme Longevity 16:42 Genes that Regulate Aging: mTOR, AMPK, Sirtuins 21:47 1,161 Comments rongmaw lin Add a comment... Gadinata Gadinata 3 months ago I have been following Dr. Sinclair since I was 33. I am 30 now. 1K Chris Williamson Chris Williamson 3 months ago Love this. Congrats mate! 95 Belinda Belinda 3 months ago Love the dynamic, having someone to bounce ideas and questions about this topic is important! Thank you both for this platform 🙏 13 Zala Reverie Zala Reverie 3 months ago I have been counting down and now this podcast is finally here! I am greatly inspired by you and Dr. Huberman and i'll be forever grateful to Lex Fridman to introducing you both to me. Keep changing the world for the better! <3 456 Jennifer Donnelly-Monte de Oca Jennifer Donnelly-Monte de Oca 3 months ago I loved your book and recommended it to countless other healthcare professionals. Really exciting stuff! This podcast was excellent. I just can't say enough great things about you and your work. I'm so grateful that you are doing this podcast so that everyone can get as excited about these incredible advancements as I am! 11 Jeff Nixon Comedy Jeff Nixon Comedy 3 months ago This is going to be such a powerful podcast. Can’t wait! 130 Bill Garner Bill Garner 3 months ago David, I would like to personally thank you for your life‘s work and the work that you are doing in reversing biological aging. As one of your students applying the information gleaned from your research to my personal life and to the lives of the medical practices and companies we serve. All I can say is this is a hell of a lot of fun :-) 72 Maciej Kiszka Maciej Kiszka 2 months ago Excellent stuff! I read the book about a year ago, so I'm really looking forward to finding out what' changed and the greater specifics on how to have a greater healthspan. 2 Luis Rodriguez III Luis Rodriguez III 2 months ago I'm SOOOOOO happy that we finally have a David Sinclair podcast. Please keep this up, I look forward to the future of the show and the science that it'll teach. 2 Wednes Day Wednes Day 3 months ago I'm sure I speak for all of my fellow science lovers when I say, thank you for doing a podcast. It's so exciting! 😊 28 Vladimir Ivanov Vladimir Ivanov 3 months ago Awesome first episode! Really looking forward to future episodes. This field definitely needs more popularization to change people's perspective on aging. 8 Brent Nally Brent Nally 3 months ago I’m stoked David finally has his own YouTube channel! Let’s all work together to solve aging ASAP! 186 Tonya Mckimmy Tonya Mckimmy 3 months ago On my last leg of treatment for Lyme Disease. I sincerely thank you and Professor Huberman. Your teachings have given added strength to my hope that helps me carry forward. 26 Adam S Adam S 3 months ago Waiting an entire week to hear the next episode is aging me significantly 😂 fascinating stuff and can’t wait to hear more! 12 Paul o connor Paul o connor 3 months ago I've been so excited about this podcast....Here we go. Love your work David and thanks for bringing us this free information. 12 Danovic Danovic 3 months ago Love this! Every bit of knowledge I can get about longevity I'll gladly take. Thank you David, for everyone you do for humanity! 12 brooklyn brooklyn 3 months ago Way to go David! I've watched many of your interviews on Rogan, and Lewis Howes and Impact Theory, glad to see you made your podcast! Congrats! 3 teddy teddy 3 months ago I cannot wait to see what’s this podcast going to bring to the table! I learned about Dr. Sinclair on Whitney Cummings’ podcast and immediately after I read your book! Fast forward a few days and I decided to study Molecular Science in University to hopefully research aging one day! I cannot express my admiration for you enough! 34 Satbir Aulakh Music Satbir Aulakh Music 3 months ago Thanks again David. Your book has changed my life and life of hundreds of my patients. I work as a GP in Darwin 18 Simon Foo Simon Foo 3 months ago Excellent way to allow layman like me to understand better about the science behind aging. I have listened many of Dr. Sinclair's talks and interviews but this podcast is really well orchestra to enable viewer to better understand the subject matter. Thank you very very much to both of you. I really enjoy watching it and forget to eat my lunch, which is a good thing to miss! 8 Brittney Tan Brittney Tan 3 months ago (edited) I can't wait for the next episode. This topic is near and dear to my heart, i want to live forever, or as long as i am able. I enjoyed the podcast, I never knew you're so funny Dr. Sinclair! 32 tygrera tygrera 3 months ago I am so glad that this is happening, I've been a fan for a long time, absolutely love your book, much love from the Netherlands 6 Microwave Engineer Microwave Engineer 3 months ago The combination of a scientist and a journalist for a podcast is just a match made in heaven. This is gonna be great! 22 Drew Moon Drew Moon 3 months ago Congratulations on your official appreciated podcast. As an Aussie living abroad, you are a guiding light of inspiration. Thank you, Mate! 25 Milorad Milutinovic Milorad Milutinovic 3 months ago (edited) He finally got his own channel, was much more difficult than to reverse the aging 😂 15 Longevity Plan Longevity Plan 3 months ago We’re super jazzed David has his own YouTube channel and podcast now! The future is looking great! 69 Nick Dirienzo Nick Dirienzo 3 months ago Thanks so much for starting this podcast series Dr. Sinclair! Matt's inclusion on this podcast is immediately evident to me to be a great decision, acting as an audience member (in a sense) asking the questions that many of us would in real time. Great format 👍 34 RennieV RennieV 3 months ago Thank you so so much for bringing this to the world. Dr Sinclair, you are a gift! And Mr LaPlante, thank you for the questions you bring to the discussion. It really helps reiterate and clarify the information. Thank you both so so much! 4 Janis Gailis Janis Gailis 3 months ago (edited) Dr. David, I have been following you for ages already, so happy to see you starting your own Podcast. Looking forward to every moment with you. 2 Paul Camdar Paul Camdar 3 months ago This is simply incredible. Thank you Dr. David Sinclair. 25 Ali Haji Ali Haji 3 months ago Dr. Sinclair is a hero. We owe him a debt of gratitude. I have been following him and his work since 2016 like every single week. I'm so glad that there is a podcast now! The only thing that I'm worried might derail this fantastic and groundbreaking research is the political turmoil in the US. We need to make sure that this research reaches fruition no matter what. 8 Sam Heine Sam Heine 3 months ago (edited) I appreciate everything you guys are doing. And I'm glad to see an official channel dedicated to your work. I know you've got things in the works right now that you can't discuss that are in trials right now, but maybe some hints on your progress would be exciting. Thank you. Sam 44 Marta Ilieva Rangel Marta Ilieva Rangel 3 months ago Happy New Year David - a long awaited podcast 🙌🏼Thrilled to find out more in the subsequent episodes. Thank you 🙏🏼 10 Odminey Piju Odminey Piju 3 months ago I am 27 and in the last few years I began to notice, that some of my peers are aging much faster than me. This observation caused me to often contemplate the topic of aging, and when I listened to Dr. Sinclair on Huberman Lab, I subscribed to Lifespan right away. Thank you for your work and for making this information accessible! 12 Edison Ryan Edison Ryan 3 months ago I'm 15 and I'm so fascinated by the forefront research and discoveries in the field of longevity and I'm so glad you started this podcast! Thank you so much, can't wait for future episodes! 5 Red Pill Lense Red Pill Lense 3 months ago (edited) This is AWESOME! Thank you, Dr. Sinclair, for doing the good that helps humanity. You are God sent! 19 Farhad Khan Farhad Khan 3 months ago I’ve read Lifespan several times and been eagerly waiting for the latest updates from David Sinclair’s research. So glad to see this podcast. 2 Jeff Middlebrook Jeff Middlebrook 3 months ago Thank God for leaders like David who genuinely want to help mankind. My wife and I are 65 yo and we want life after 65 to be our active second life not a death sentence. We plan to share this information to whomever will listen and become disciples of longevity. 140 Elena Teplushkina Elena Teplushkina 3 months ago I'm very excited about this. I've just finished the episode from Huberman Lab podcast. You and Dr. Huberman briefly touched on the topic of fertility and age-reversing. I would be happy to learn more about it and the protocols women can benefit from to extend their fertility age. Thank you! 126 james carpenter james carpenter 3 months ago I would just like to thank you for your courageous efforts in keeping us all healthy and young if possible. I am sure that your grandmother is really proud of you now. I have been following you for several years now and find that Your explanation of your research is down to earth and clear especially for a nonscientist. I truly do hope that when you come out with formulas for the rest of us to take they will be available to all at an affordable price as you have said you would in past talks. NMN sounds very promising. Keep up the great work looking forward to all of your talks and podcast and once again I👏Applaud you 8 Vicky Daisy Vicky Daisy 3 months ago Happy New Year Dr- David Sinclair. Thank you for developing the podcast. Amazing contents to be followed. 14 Divya Bhatia Divya Bhatia 3 months ago Thank you so much for starting such an amazing podcast and providing amazing information free of cost. You are an amazing researcher, human being and an inspiration. And thanks so much for amazing research you do and for teaching how we can use that information and implement it in our daily lives to make it better. 3 Perla Chavarría Perla Chavarría 3 months ago It's inspiring to see people in the scientific field working towards the wellbeing of people (spreding the word outside the field). Thank you for the wonderful work! It will have a huge impact on people :) Here to learn! Greetings from Monterrey, Mexico :) 3 Sam Patterson, P.A. Sam Patterson, P.A. 3 months ago (edited) Amazing content! Thank you for starting these! Have purchased the book-which is amazing! 15 Armie Flores Armie Flores 3 months ago I have been following you Dr. D. Sinclair, so excited to hear all brilliant information for longevity and healthy life.Thank you an awesome work with your team and sharing it to us. 2 Roberto Benedit Roberto Benedit 3 months ago Excellent, first Andrew, now David, life can't be better! Cheers for science! #scienceRules! 24 colin young colin young 3 months ago Looking forward to following this podcast. May it be fruitful with a long lifespan. 10 Lotfi Bouhedjeur Lotfi Bouhedjeur 3 months ago I'm bursting at the seams with excitement! Dr. Sinclair has an official YouTube channel. I love how assertive he sounds talking about what he knows. 6 Larmik VonHorshley Larmik VonHorshley 3 months ago I really appreciate Dr. Sinclair and the work h puts into making information so crucial to a long and healthy life available and accessible. The child in me can't help but see The crocodile hunter and The House of Pain guy having a casual conversation about epigenetics. We live in amazing times and are so fortunate that such dedicated people are willing to give so much of their valuable time to share their life's work with the world. I am both filled with gratitude and deeply humbled by this generosity, thank you both so much. 3 Dylan Dylan 3 months ago I discovered you thanks to Andrew Huberman, currently reading your book and am hyped for this podcast!. I have a feeling its going to be an amazing one. 20 Better Humanz Better Humanz 3 months ago So excited this is finally happening :0. I started your protocol 6 months ago aswell as a few other things and can't wait to start sharing my journey when I get the 2nd bloodtest from Inside Tracker...What I can tell you is I feel incredible....Lets get this train rolling! 4 Heath Company Heath Company 3 months ago I eagerly await every Monday for Andrew Huberman's life-changing podcast. And now you're telling me that I get another podcast on Wednesday? Amazing! 9 Przemyslaw Petka Przemyslaw Petka 3 months ago Wow That was great conversation. I saw your conversation with Andrew Huberman but I found it just too bit complicated for a newbie to digest TBH, but this podcast is different. I feel like you and Matthew have a power to propagate those complex topics to people who have never heard/read about this stuff. Cant wait for the next podcast! Thank you for that! :) 26 Becca Petit Becca Petit 3 months ago Thank you greatly! The fact that aging can be stopped and reversed is amazing! I love that we have geniuses like you David who care to share this information in a simplified educational and applicable way! You and Andrew Huberman are in my top podcast favorites! Thank you again and please keep it up. 1 Massimo Massimo 3 months ago Wish you good luck with this new endeavour! I've started reading your book recently, so interesting and fascinating can't wait to learn more 4 turkishromeo83 turkishromeo83 3 months ago Huberman Lab & Dr. David Sinclar, absolutely the Best of Best 🙌🏼 Thank you so much for sharing all your knowledge for free with us 🙏🏼 13 Jennifer Strahan Jennifer Strahan 3 months ago Absolutely amazing. This was more than I had hoped for, so much fantastic, mind blowing information. I cannot wait to be able to test my biological age affordably and often. I am very much looking forward to the subsequent episodes and the upcoming book! Thank you Dr. Sinclair for taking the time out of your very busy schedule to make this happen for all of us, this is truly a gift! 2 Kriz Wang Kriz Wang 3 months ago Congratulations Dr. Sinclair! This podcast is going to be epic 👍 17 carpe diem jonah carpe diem jonah 3 months ago (edited) What a great way to go around the mainstream medical establishment and present the greatest research in real time directly to the common man. Your research is benefiting mankind at speeds unheard of, and imagined by the mainstream. The "mainstream" is withering from old age. 18 Cat Steinhilb Cat Steinhilb 3 months ago (edited) Thank you both for this … this is immensely valuable to all us humans striving to live longer, healthier lives ❤️ Steve Lacy Steve Lacy 3 months ago This was a great podcast, thank you ,can't wait for the next one. 6 Pietro Adorni Pietro Adorni 3 months ago Read Lifespan and now listening to this. What a great opportunity to solidify the concepts expressed in the book and be up-to-date with new research. 3 Maria Morris Maria Morris 3 months ago I discovered Dr. Sinclair when Andrew Huberman had him in his podcast, love and appreciate how they are informing us. Thank you, gracias❤ 3 GG Brait GG Brait 3 months ago THANK YOU!!! This is awesome! Grateful to my favourite members of the humankind, Lex and Andrew, for introducing Dr. Sinclair to someone like me🙏❤️ 9 Jeen34 Jeen34 3 months ago Hello doctor! I've been waiting for this for a while, really happy to finally see it! My question for you (or anyone on the production team) is: are insidetracker and levels available in Europe? Specifically I'm in the Netherlands, and I would love to try both of them! Thank you for the amazing podcast :) 18 Natalie Axl Natalie Axl 3 months ago Love you David!! Appreciate all the study and research you do and keeping us in the loop of your discovery 🙏🎊💕 Blessings 🙏 6 Milda Goes Wild Milda Goes Wild 3 months ago It's good to have a podcast coming directly from David as opposed to random interviews by others. 3 Asad Asad 3 months ago This is such an amazing thing David has done to fans. It's going to be great! 3 Better Humanz Better Humanz 3 months ago Incredible, loved all of it..got some amazing new information for example the HbA1c and how Metformin can help. My levels were at 5.6% when I had my first Insidetracker test done last October so will be interesting to see what they are at soon. Can't wait for the next episode! 3 Esdras Almeida Esdras Almeida 3 months ago Learned a lot on this episode, i'm definitely watching all of it! I am facinated on how much science has developed so far about aging and so enthusiastically about researching it. 6 John Judson John Judson 3 months ago Thank you Dr. Sinclair and Mr. LaPlante for your book and now this podcast. When it comes to health, I feel like I have been stumbling around in the dark my whole life. The context and data that you have structured so beautiful is giving me hope that an actual and manageable path to health is within reach. You guys rock! 7 Bernard Radcliffe Bernard Radcliffe 3 months ago I am looking forward to the next 7 podcasts. And I can't wait for the new discoveries just around the corner that will change everything we know about age related diseases. 3 Volodymyr Surma Volodymyr Surma 3 months ago Thank you so much for sharing this with us! I’d very much like to also hear your thoughts about ASD, Dr. Sinclair. 1 in 44 children in the U.S. is diagnosed with an autism spectrum disorder (ASD) and this epidemic is global. There is no known single cause for autism spectrum disorder, some say it’s genetics, some say it’s environmental. most children have gastrointestinal, mitochondrial, sensory issues, inability to detoxify and the list goes on. These kids are born with ASD. Please share your thoughts on this disorder, is this related to early aging and can we fix these so called “dirty genes”. As a mother of an autistic 3 years old child, I’m eager to learn more about this and help my child as much as I can. 3 timvw01 timvw01 3 months ago Great podcast, very interested in the following episodes. Well done!💪 2 Alvaro Mengual Alvaro Mengual 3 months ago AWESOME!!!! I see great success for this podcast! Maybe the Science behind aging got its iPhone moment!!!! Great work guys I can't wait to see future content and the result of future research! By the way your mics sounds great however, the mic captured a little bit of eco form the room. I already subscribe and visit your sponsors so that you guys keep building the podcast. 2 Alain Kelder Alain Kelder 3 months ago So excited for this! After reading Lifespan wanted to keep following the developments and maybe add longevity molecule supplementation to my regimen of IF, exercise, sleep, breathing and cold exposure, but finding it hard to weed out the BS. Looking forward to the latest info from the leading researcher himself! :-D 1 Aeon Proelium Aeon Proelium 3 months ago Great podcast. Seen you, David, on Rogan and Andrew's podcasts and been waiting for this to happen. Love it and look forward to more! Thank you 1 Sebastian Niemann Sebastian Niemann 3 months ago Amazing podcast 🙏❤️- already looking forward to part 2 5 porchzombie porchzombie 3 months ago Can't wait to hear the rest of this series... this is some amazing stuff! 3 DeepMindOfMe DeepMindOfMe 3 months ago I have been looking forward for your podcast for a while now and I am happy it is finally here :) thank you and keep changing the world for the better :) 3 Alexander Toronto Alexander Toronto 3 months ago Thank you Dr. Sinclair and to your colleague for starting your own podcast- I have been following your youtube broadcasts for 2 years now and find it fascinating. If you require any volunteers for your work - I am ready, thank you :) 3 Howitz Howitz 3 months ago (edited) Covid made me reconsider my life priorities and made me decide to go back to school and study biochemistry and molecular biology. I've read some of your works about the expression of 3 of 4 yamanaka factors in mice and it made want to focus my studies on trying to prolong human life / quality of life. Thank you! I feel like our current lifespans are a bottleneck to our civilization's advancement. Imagine what could be if our greatest minds could live and thrive for 30-40 more years in their prime. 3 Dennis Wiersma Dennis Wiersma 3 months ago Amazing dr Sinclair! Love the work you're doing. 3 Volker Hiddemann Volker Hiddemann 3 months ago Thank you Dr. Sinclair for this insanely insightful work that you provide. It’s a pure pleasure to listen. It makes me smile to whiteness the similarities between your and Dr. Huberman’s podcast, knowing of course that he helped to ramp this up. It’s great to have such powerful people see collaborate. Matthew La Plante brings a nice twist to the topic. Highly enjoyable. Looking forward to the following 7 episodes. 3 Melissa Ebbert Melissa Ebbert 3 months ago Yes!!!!! So excited for this! Just started taking NMN a week ago and have been feeling so full of positive energy and able to focus so much better! Thank you David for sharing more of your mind with us!! 3