NAD+ Boosters for Longevity

Better than NMN & NR: Future of NAD+ Boosters for Longevity | Dr. Nichola Conlon & Beyond Sapiens Beyond Sapiens 8.2K subscribers 62K views 2 months ago #nmn #aging #nr In this interview with Dr. Nichola Conlon, founder and CEO of Nuchido Laboratories, we shed light on NAD+, its significance, and ways to increase it. We also delve into the scientific aspects of NMN and NR while discussing the next-generation NAD+ supplement Nuchido TIME+. … 189 Comments rongmaw lin Add a comment... @beyondsapiens Pinned by Beyond Sapiens @beyondsapiens 2 months ago The clinical trial mentioned in the video is currently being peer-reviewed. It will be published in a prestigious scientific journal, and we'll update the description with the link once available. Thanks for your views and support!😊 22 Reply @mustafademirkol82 @mustafademirkol82 2 months ago Here is a summary of the key points from the video: - NAD+ is a critical molecule for cellular energy production and repair that declines with age. Boosting NAD+ may promote longevity. - Popular NAD+ precursors like NMN and NR may provide some benefit but don't address the root causes of NAD+ decline. - The root causes are declining NAD+ recycling enzymes and increased inflammation. NMN and NR simply provide more raw material. - Dr. Nichola Conlon created Nuchido TIME+ to target the root causes. It contains nicotinamide plus ingredients to boost NAD+ recycling and reduce inflammation. - A placebo-controlled, double-blind crossover study on TIME+ showed it significantly increased NAD+ levels, NAD+ recycling enzymes, sirtuins, and reduced biological age in 28 days. - Future Nuchido products will likely target cellular senescence. - Dr. Conlon believes future anti-aging treatments will make age-related decline seem inhumane, much like current views on allowing cancer. In summary, the video explains how Nuchido TIME+ targets root causes of NAD+ decline and showed significant anti-aging effects in a robust clinical trial. Future longevity treatments may make aging as we know it obsolete. 80 Reply 7 replies @Travelbythought @Travelbythought 2 months ago I would prefer regular niacin over the non-flushing kind, as the flush has some benifits and is more gentle on the liver. It is good that there are more options out there becoming available. We are still in the early days of this research. 13 Reply @fxn @fxn 1 month ago I like the science she explains, but also what she transmits as a person. I was on NMN + Resveratrol, but Nuchido got a new customer. 3 Beyond Sapiens Reply @vivaldez @vivaldez 2 months ago 🎯 Key Takeaways for quick navigation: 00:00 🧬 Introducción a NAD+ y su importancia en la longevidad. 03:23 📉 Consecuencias de la disminución de NAD+ en el envejecimiento. 07:16 🏃‍♂️ Formas naturales de aumentar los niveles de NAD+. 10:20 🧪 Funcionamiento de NMN y NR como precursores de NAD+. 14:39 🔬 Limitaciones de los precursores NR y NMN. 19:51 🆕 Nuchido TIME+: Una nueva generación de potenciadores de NAD+. 22:41 🧬 Importancia de la nicotinamida como precursor de NAD+ 26:35 🧪 Estudio clínico de doble ciego y controlado con placebo 32:47 🔮 Futuro de la longevidad y Nuchido Laboratories Made with HARPA AI 3 Reply @Tron-Jockey @Tron-Jockey 2 months ago One of the issues with NMN and NR is that it only affects blood levels of NAD. These have not been shown to increase the levels of NAD in the bone or muscle tissue. Has anyone heard anything else about how this product is different? 7 Reply Beyond Sapiens · 1 reply @catman4471 @catman4471 2 months ago £60.00 for a months supply or £165.00 for 3 months as opposed to £99.00 for 100 days NMN from donotage. I'm getting great results from NMN, not sure why I should change to something more expensive. 17 Reply Beyond Sapiens · 8 replies @fasteddylove-muffin6415 @fasteddylove-muffin6415 1 month ago My God this is deep. It's going to take a whole lot more research as far as lifestyle & diet to get those optimal NAD levels up & running. 1 Beyond Sapiens Reply @metaphysicalArtist @metaphysicalArtist 2 months ago What is the Optimal NAD+ levels ? , yougotthis and if you have way to high NAD+ levels is it BAD? - Typical NAD levels vary considerably by age and unit of measurement. NAD levels within cells can range between 10 and 1000 μM. Additionally, total NAD values were observed to range between 0.3 and 0.4 μmol/g. 3 Reply @Dr.AnonymousPro @Dr.AnonymousPro 2 months ago I'd advice an alternative, one brand I have the best experiences with is: Greenfood. They have Vitamin B3 (Niacin) high dose. And yes, it causes the flush, but you can limit that with some tricks. The other ingredients of the rather expensive Nuchido time stuff are easily available from nature. I mean, just take the parsely and green tea fresh! Grow your own if you can. 5 Reply 2 replies @peterz53 @peterz53 2 months ago (edited) Follow up NAD+ effects of Time+: Please correct me if math is wrong. NAD+ has a molecular weight of about 660 grams per mole. Typical NAD+ levels appear to be on the order of 40 to 60 micromolar intracellular although some google scholar papers mention blood as opposed to intracellular. The Jinfiniti site which does NAD+ testing reports in micromolar and shows optimal values roughly on the order of 50 micromolar, so expect typical baseline to be lower. Converting 50 micormolar NAD+ to ng/ml I get over 30,000 ng/ml which is huge compared to the increase Nuchido showed of about 17 ng/ml. Calculation below. 660 grams/mole for NAD+ 50 micromolar is 0.00005 mole/L 0.00005 mole/L x 660 gms/mole = 0.033 gm/L 1,000,000,000 ng/gm x 0.033 gm/L = 33,000,000 ng/L 1000 ml/L 33,000,000 ng/L x 1L/1000ml = 33,000 ng/ml If someone here has the skill to do the conversion and check this please do as I don't want to misrepresent Nuchido's results, but so far Nuchido has not clarified what the baseline values of their subjects were or offered up typical values for comparison. One poster noted that he got 33 ng/ml but I did not see his work and he has not yet commented on my details shown above.. 3 Reply 2 replies @adamcohen1391 @adamcohen1391 2 months ago The only really important question here is, how does this product compare to NMN or NR. I’m sure that comparison study will never be done, though. 2 Reply @chucklohn522 @chucklohn522 9 days ago I think that the good thing about these supplements is that you can actually measure the results with blood tests to measure the Telomere lengths? Has this been done for this supplement approach? 1 Reply @cravarc @cravarc 2 months ago Sounds great but too pricey compared to the NMN powder I use (RBS). I like that TIME+ is a pill rather than taken sublingually. I use apegenin with my sinelytic cocktail; I'll research if I should also take it daily with NMN and TMG. 7 Reply 5 replies @4406bbldb @4406bbldb 2 months ago I’m so happy with my 76 year old energy level. A young lady I talk with said, you have the energy of someone 30 years younger, maybe I have more work to do. I MB routinely don’t eat sugar or processed food ect. Thanks for the video. 3 Reply @berdi4berdi4 @berdi4berdi4 2 months ago (edited) Niacin (or Ncotinic Acid) is another NAD+ precursor which isn't mentioned in the video, much cheaper than NMN and NR. 63 Reply 40 replies @user-ex6wb8mu8i @user-ex6wb8mu8i 2 months ago @beyondsapiens If fasting activates NAMPT and NAMPT signals to convert NAD precursors such as NMN or NR into NAD then it is clear that taking them during fasting should increase NAD levels. Can this assumption be addressed to Dr. Nichola Conlon? 6 Reply @thewizardTim999 @thewizardTim999 2 weeks ago Niacin (B3) and niacinimide (nicotinamide) both enter cells through passive transport. No ATP is required. NMN must be converted into NR and then can be absorbed through ACTIVE transport. Niacine and niacinamide are less expensive, can be taken in higher molar concentration, and are likely to be more quickly absorbed. Niacinimide is the primary and limiting storage substrate of the salvage pathway to make NAD. Ribose is present in abundance. Reply @normacatlin5199 @normacatlin5199 2 months ago I understand you want to give us the latest and greatest but I’ve yet to hear about the purity I know N M, and can be real sketchy as far as how it’s made in the purity of it and I love the idea that a lot of your additives come from the real deal as far as plants go 1 Reply @cathompson58 @cathompson58 2 months ago Interested but skeptical.. this was more like an infomercial than scientific discussion... staying on DoNotAge NMN 1500 mg/d + TMG 1500 mg/d + Apigenin for now but I will watch this with interest 14 Reply Beyond Sapiens · 3 replies @brent2630 @brent2630 2 months ago I would love to see if there is a benefit to taking Time+ and taking NAD+ through an IV. 2 Reply Beyond Sapiens · 4 replies @luckssj @luckssj 2 months ago I have increased my NAD by NMN and taking Fisetin to lower CD38 so it can work 6 Reply Beyond Sapiens · 4 replies @jimmiandersen3099 @jimmiandersen3099 2 months ago Great interview. 1 Beyond Sapiens Reply @fasteddylove-muffin6415 @fasteddylove-muffin6415 1 month ago At around @36:30, granted we have turned the corner on cancer but not completely, I get it though. That it is over the course of many decades that our attitudes & approach to cancer & aging change. I pray for a more humane approach to both. Beyond Sapiens Reply @karenfarrell6158 @karenfarrell6158 1 month ago Thank you so much for this info. Beyond Sapiens Reply Beyond Sapiens · 1 reply @craigmears943 @craigmears943 2 months ago (edited) I haven't watched the video all the way through but at 24mins and 55 second it talks about methylation. I take NMN with TMG, too which TMG supports methylation. If I switched to Nuchido Time+, would I need TMG or a version of it? Also if using Nuchido Time+ would I still receive the same benefits of NMN (1000mg) like increased energy, eye sight correction etc? 1 Reply Beyond Sapiens · 2 replies @polpolo7352 @polpolo7352 2 months ago I saw a research about NAD and publications that say that as nad increases so much energy to high levels, can be dangerous for cancer of pancreas in particular. Do you agree with that? Reply 1 reply @criostoirashtin11 @criostoirashtin11 8 days ago B3 (NAD) and apigenin (CD38) Reply @CyrilAndPriscilla @CyrilAndPriscilla 2 months ago I notice that this product ALSO includes an NAD+ precursor, niacinamide. If the argument is that we don't NEED NMN precursors if we just address the recycling problem, then why bother including an NMN precursor in the Nuchido formula at all? Also, why include the NMN precursor niacinamide and NOT the precursors NMN or NR? Is there some benefit to niacinamide versus NMN or NR? Reply Beyond Sapiens · 3 replies @treinos5528 @treinos5528 4 weeks ago great information Reply @rajeshchheda456 @rajeshchheda456 2 months ago Nuchido is just the beginning, going ahead, we will have more cocktails and all of them will work. 3 Reply 1 reply @metaphysicalArtist @metaphysicalArtist 2 months ago What is the optimal NAD+ level per decade (I am 63 on 1gr of NMN) 1 Reply 2 replies @user-qc4sf4pt3t @user-qc4sf4pt3t 2 months ago But by comparison to supplementation how much does fasting raise nad? Reply 2 replies @alexandrina...966 @alexandrina...966 2 months ago Thank you👏😎🥳 Reply @edmundodante4091 @edmundodante4091 2 months ago The question is: does the advertise product indeed elevate NAD levels withinth cells???. SO fan Neither MNM or NR do elevate NAD levels in cells. How about your advertised product ? Reply Beyond Sapiens · 1 reply @redpillsundayschool6450 @redpillsundayschool6450 1 month ago In reading these obnoxious comments, has anyone had any experience in trying both supplements, that is, MNM combined with this new TIME+ ? Seems like they would be either complimentary or co-beneficial to one another, or that the one would be protective from the other's potential side effects? Anyone? Reply 1 reply @primobadboy @primobadboy 2 months ago The treatment looks great. The website to purchase the product is useless to me. No paypal, no pay by check, does not accept my debit card. I wish this was not in my feed. Reply @peterz53 @peterz53 2 months ago (edited) Data ?? The slide you showed at 30 min was old preliminary data and has nothing to do with the more recent trial which was discussed. The trial which now has slides on the Nuchido web site and which was discussed here shows about a 17 ng/ml increase in NAD+ above "baseline." This might be "statistically" significant but how does this compare to baseline levels. Baseline levels are not disclosed, but from what I can gather a 17 ng/ml increase in cellular NAD+ is fairly small compared to normal levels at most any age. None of the slides on the web site show data in which one can tell approx percentage change above normal levels for the parameter in question. Do you have baseline data to disclose? 14 Reply Beyond Sapiens · 3 replies @myoption100 @myoption100 1 month ago What is the MNM process for purity and potency Dr. Sinclair has enzymatic process Reply @danielalbuquerque3909 @danielalbuquerque3909 2 months ago Nicotinamide (NAM) and nicotinamide mononucleotide (NMN) are both precursors of NAD+, but they have different bioavailability. Nicotinamide is a direct precursor of NAD+, but it is less bioavailable than NMN. This is because nicotinamide needs to be converted to NMN by the body before it can be used to produce NAD+. NMN is an indirect precursor of NAD+, but it is more bioavailable than nicotinamide. This is because NMN can be absorbed directly by cells and converted to NAD+ without the need for additional conversion. A study published in 2022 in the Journal of the American Medical Association found that NMN was absorbed more rapidly and efficiently than nicotinamide in humans. The study also found that NMN increased blood NAD+ levels by up to 20%, while nicotinamide had no significant effect. In summary, NMN is the best NAD+ precursor with the highest bioavailability. This means that NMN is more effective at increasing NAD+ levels in the body than nicotinamide. However, it is important to note that more research is needed to determine the long-term efficacy and safety of NMN and nicotinamide. ::::: According to available scientific studies, fisetin is the best natural supplement for activating NAMPT and recycling NAD+. ::::: Fisetin is a flavonoid that is found in fruits such as grapes, strawberries, and onions. In vitro and in vivo studies have shown that fisetin can increase the expression and activity of NAMPT. A study published in 2022 in the Journal of Cellular and Molecular Medicine found that fisetin increased NAMPT expression in human cells by up to 50%. The study also found that fisetin increased NAD+ production, which is an essential cofactor for many cellular functions, including ATP synthesis, DNA repair, and stress response. Another study published in 2022 in the Journal of the American College of Cardiology found that fisetin increased NAMPT activity in mice. The study also found that fisetin reduced inflammation and improved cardiac function in mice. Rutin (quercetin) is another flavonoid that has been associated with NAMPT activation. However, the studies on rutin for NAMPT activation are less conclusive than the studies on fisetin. Resveratrol, EGCG, and coenzyme Q10 are other natural supplements that can activate NAMPT, but they are less effective than fisetin. In summary, fisetin is the best natural supplement for activating NAMPT and recycling NAD+. However, other natural supplements, such as rutin, resveratrol, EGCG, and coenzyme Q10, may also be beneficial. But again Fisitin is better. ------------------------------------------------------------------------------------------- Which cells cause more inflammation? T cells or B cells? In general, T cells are considered to be the main drivers of inflammation. They secrete pro-inflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), which stimulate the inflammatory response. B cells can also contribute to inflammation, but in a more indirect way. They produce antibodies, which can bind to antigens and trigger the activation of T cells. Additionally, B cells can produce pro-inflammatory cytokines, such as IL-6. However, it is important to note that inflammation is a complex process that involves multiple cell types and molecules. The role of T and B cells in inflammation can vary depending on the type of infection or disease. In some cases, B cells can even suppress inflammation. For example, regulatory B cells (Treg) secrete anti-inflammatory cytokines, such as IL-10. In summary, T cells are considered to be the main drivers of inflammation, but B cells can also contribute to this process. The role of T and B cells in inflammation can vary depending on the type of infection or disease. Basic advice Based on the latest scientific studies, the best way to reduce inflammation is to take Fisetin and NMN and you can also take Apigenin (optional) in the form of powdered parsley. Fisetin will lower CD38 inflammation in T cells by up to 70% and apigenin CD38 in B cells by up to 80%. Plus, fisetin will activate NAMPT and still eliminate senescent cells. 3 Reply Beyond Sapiens · 6 replies @denellesheridan4599 @denellesheridan4599 2 months ago Is this available in Australia? How much does it cost? Reply Beyond Sapiens · 3 replies @swim610 @swim610 2 months ago Could this help long covid? Reply @HH-gv8mx @HH-gv8mx 1 month ago Why not just take NAD? Reply @vimlafries5485 @vimlafries5485 2 months ago ❤️🌹🙏😀👍 1 Beyond Sapiens Reply @jakobw135 @jakobw135 2 months ago WHERE are is her nicotinamide supplement available? Reply @y.g.1313 @y.g.1313 2 months ago (edited) Dead end, cured nothing, achieved nothing meaningful either (like extending max lifespan). Yet, to her credit, looks like she is making genuine effort Reply 1 reply @Mike-vb6qw @Mike-vb6qw 2 months ago When is the best time to take this supplement? Reply Beyond Sapiens · 1 reply @Sweetp520 @Sweetp520 2 months ago Couldn't find a place to use your code , so havent purchased yet. Reply Beyond Sapiens · 1 reply @whiskerske3218 @whiskerske3218 2 months ago I tried to purchase her supplements but I guess they don’t ship to Hawaii. Bummer! Reply @BK-dy8jk @BK-dy8jk 1 month ago I just can’t take niacin. It just makes me nauseous and sick and very uncomfortable. NR or NMN. Starting to sound like we have to block CD 38 otherwise NAD is gobbled up before it does anything. Reply @laszlok53 @laszlok53 7 hours ago Extremely, I mean EXTREMELY expensive supplements. Reply @thecryptobunker @thecryptobunker 3 weeks ago Wish there wasn't seed oils in it ugh (sunflower oil), was just about to purchase. Reply Beyond Sapiens · 3 replies @Helium333-pj2jt @Helium333-pj2jt 2 weeks ago She's good looking AND smart. Ticking all the boxes..... I wonder what she takes herself?! Reply @tadpoleman3879 @tadpoleman3879 2 months ago I wish experts would stop using acronyms in their video titles. I generally skip these videos because I ask myself, why do I want to waste my time if it's over my intellectual level. "😢" I'm a non-smoker, a non drinker, and an avid vitamin/mineral taker. I still lack energy! I live a low sugar diet. Reply @williamtomkiel8215 @williamtomkiel8215 2 months ago waiting to see when Dr. Rhonda Fleming chimes in . . Reply @WW-fr6um @WW-fr6um 3 weeks ago She looks like the doctor in Saw 10 Reply @nadeemkhanftii @nadeemkhanftii 2 months ago Not convincing and. far too expensive 2 Reply 1 reply @vickybiagini8623 @vickybiagini8623 2 months ago There is no such thing as longevity. I dont know why this word gets thrown sround do much. You start sging st 40, snd are old by 50. Sging is hard, brutal and ehy would a person want to live in a decaying body for 100 yrsrs? Reply 12 replies @wmp3346 @wmp3346 1 month ago I am following Nicola’s advice. Smart and pretty 🙌 Beyond Sapiens Reply @valeriehopebennett @valeriehopebennett 8 days ago GREAT THANKS WILL TRY LOVE IT THANKS .face-red-droopy-eyescat-orange-whistling Beyond Sapiens Reply Vitamin B3 & NAD Boosting: Unexpected NMN Alternative? Wellness Messiah with Rimon 61.9K subscribers Join Subscribed 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 Share Clip Save 8,897 views Aug 26, 2023 Are you worried about the NMN ban? If the NMN ban prevents you from buying NMN or you cannot afford NMN... There is niacin , or nicotoinc acid. How do you use it properly for longevity and NAD+ boosting? This is taken from Project120. Discover if it's for you Here: https://wellnessmessiah.com/course ---------------------------------------------------------------------------------------- ✅ The favourite videos on this channel - playlist: • Longevity Favorites ---------------------------------------------------------------------------------------- The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast. ---------------------------------------------------------------------------------------- Credits: Scott Buckley Track: Midnight — Declan DP [Audio LibraryRelease]: • Midnight — Declan DP | Free Backgroun... https://alplus.io/midnight-declan-dp Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities. Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease. Transcript Follow along using the transcript. Show transcript Wellness Messiah with Rimon 61.9K subscribers Videos About 52 Comments rongmaw lin Add a comment... @WellnessMessiah Pinned by Wellness Messiah with Rimon @WellnessMessiah 3 months ago This is taken from Project120. Includes PDF slides, excel, and 3 modules in video recordings: https://wellnessmessiah.com/course 4 Wellness Messiah with Rimon Reply 1 reply @marlobardo4274 @marlobardo4274 3 months ago Thank you for your tireless research and self-experimentation what are your views of supplementing with TTFD (thiamine tetrahydrofurfuryl disulfide) or Fursultiamine instead of Benfotiamine? Wishing especially your wife well. 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @Mousehunter09 @Mousehunter09 2 months ago What is better for increasing NAD+ Level? Niacin or Niacinamide? Could you please explain that? 1 Reply @jackrabbitism @jackrabbitism 3 months ago Dr Stanfield didn’t speak against Niacin. In fact, he speaks in favour of Niacin but speaks against NMN, claiming that Niacin works better at getting NMN into muscle cells. He takes 50mg each day. 7 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies @marianaranjo1814 @marianaranjo1814 2 months ago Hallo Rimon, when you say that NMN supplement should be 1g a day to increase NAD+ levels because of gut bacteria and liver, do you refer to NMN taken in capsules or do you refer to NMN powder that is maintained below the tongue until it is completely absorbed and passed directly to the blood without going through digestive system? Thanks in advance for your answer. 2 Reply 1 reply @renasafarova1672 @renasafarova1672 2 months ago @WellnessMessiah Good evening. I'm 44. And I would like to start use NAD resveratrol, Coenzym c10, Niasinamid B3. Can you tell me how to use, how mush mg and how long? Thank you🙏🙏 Reply @oolala53 @oolala53 3 months ago I haven’t seen your videos come up recently. Glad to see a short one. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @oolala53 @oolala53 3 months ago (edited) How does it “give energy?” And with most things, there is a threshold, so it’s often NOT the more, the better. Board-certified cardiologist Dr. Alo says it is no longer believed that raising HDL has any value. Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @johnbarryyallagher1128 @johnbarryyallagher1128 3 months ago Doesn't niacin increase homocysteine? Reply @rickyida971 @rickyida971 3 months ago If take 100MG NIACIN with Vitamin C, it will reduce flushing. Will this combo reduce NAD and reduce Cholesterol effect？ 5 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies @oliverneumann210 @oliverneumann210 2 months ago What about taking NMN powder sublingual ? Reply @johngibson7693 @johngibson7693 3 months ago Are you saying a daily dose of 50 mg and divide that over the day or are you saying take 50 mg a few times a day? 2 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies @douglaswatson232 @douglaswatson232 3 months ago What form of niacin is best? 1 Reply @Leo-wo4rx @Leo-wo4rx 3 months ago I am ok with the feeling of flush, but is a flush not good for us? Reply @raelin8388 @raelin8388 2 months ago Hi Rimon .. I'm taking course 120 but don't own computer . can you make download phone friendly.. perhaps PDF file? Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 2 replies @CyrilAndPriscilla @CyrilAndPriscilla 3 months ago What about NR, Nicotinamide Riboside? Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @hunthenion @hunthenion 2 months ago So, 500 mg of sustained release niacin causes liver damage and inflammation? Reply 1 reply @Sandy-bm9qc @Sandy-bm9qc 3 months ago Will it hurt or benefit to take low dose niacin for high cholesterol along with nmn ? 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @jenxsj3902 @jenxsj3902 3 months ago I bought a year’s supply. 1 Wellness Messiah with Rimon Reply @maximebegin1454 @maximebegin1454 7 days ago 5 mins of flush for 1gr niacin??? no way i use niacin since 3 years and 500mg last 20-40mins Reply @fingersm @fingersm 3 months ago (edited) Fasting is cheapest alternative. And best 4 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 3 replies @lawnmower11 @lawnmower11 3 months ago That Alex guy interrupting you every 3 seconds was incredibly distracting Reply @liwenshih6537 @liwenshih6537 3 months ago Drink Kombucha B3? Reply @4Lights.5Liights @4Lights.5Liights 5 days ago too confusing talk show; please be clear and concise; take turns talking Niacin Increases NAD (Test Results) Conquer Aging Or Die Trying! 43K views 4 months ago Join us on Patreon! / michaellustgartenphd Discount Links: … Shop the Conquer Aging Or Die Trying! store Black Comfort Tee $25.00 Spring Black Women's Classic Tee $25.00 Spring Black Classic Long Sleeve Tee $30.00 Spring White Comfort Tee $25.00 Spring White Women's Classic Tee $25.00 Spring White Classic Long Sleeve Tee $30.00 Spring 443 Comments rongmaw lin Add a comment... @justsaying7065 Pinned by Conquer Aging Or Die Trying! @justsaying7065 4 months ago Just a minor correction: nicotinic acid is not in the salvage pathway. It's in the Preiss-Handler pathway. There are 3 pathways to make NAD: 1) de novo (starts with tryptophan) 2) Preiss-Handler pathway (starts with nicotinic acid), and 3) salvage pathway (which includes nicotinamide, NR, and NMN). 60 Reply Conquer Aging Or Die Trying! · 24 replies @edwhite2255 @edwhite2255 4 months ago Michael, i really appreciate your detailed explanation of the pathways for these biochemical reactions. You explain complex concepts in a clearly understandable way. Thx Ed 36 Conquer Aging Or Die Trying! Reply Conquer Aging Or Die Trying! · 1 reply @jrb_sland @jrb_sland 4 months ago I'm an aging [74] Canadian man who has been taking 2g/d [yes, 2000 mg] of niacin for over 25 years for "cholesterol control". My GP back then had persuaded me to start on Zocor. A couple of months later some blood tests confirmed it was working, but I whined about the cost. The GP thought for a minute, then stated that he'd forgotten to mention niacin because he himself had very bad flushing reactions. I said I'd give it a try, and here we are. My present GP tells me my blood numbers are all boringly within normal limits. The trick with niacin is to ease into large doses slowly, and if for any reason you miss a day or two, to cut the next dose to 1/4 normal & work up slowly again. For those utterly new to niacin, I'd suggest starting with half a 500 mg tablet per day for a couple of days, then start increasing every couple of days by no more than 250 mg/d until you reach your desired target, somewhere between 1500 mg/d and 2500 mg/day. At these high doses, I'd also suggest taking half the dose in early morning & the remainder in early evening to reduce the likelihood of annoying flushing. BTW, I am NOT obese, & do NOT suffer from T2D, so I'm not terrified that high-dose niacin will do me any harm. 20 Reply @r.d.7248 @r.d.7248 4 months ago Thank you for another outstanding video! Your commitment and dedication are greatly valued and appreciated. 24 Conquer Aging Or Die Trying! Reply @Liface @Liface 2 months ago Lustgarten out here straight up running one of the most valuable n=1 experiments known to humanity. This man will be talked about for years in the future. 2 Reply @johnbarryyallagher1128 @johnbarryyallagher1128 4 months ago Interesting, as usual. It is always hard to remove the time response component as I noticed what looked like a decay function after your NMN peak. Then of course it is difficult to control for life style such as change in excercise regime etc. Nevertheless, you are looking for big size effect which can overcome variability constraints, I guess. Looking forward to you blood test results😊 1 Reply @Elaba_ @Elaba_ 4 months ago The effect of taking vitamin B3 on angiogenesis and its impact on cancer growth is an interesting topic that has been investigated in scientific literature. Vitamin B3, also known as niacin or nicotinamide, is an essential nutrient that plays a significant role in various biological processes. Angiogenesis is the process of forming new blood vessels from existing ones. It is a crucial step in tumor growth and development as it supplies the tumor with nutrients and oxygen, which are essential for the proliferation and survival of cancer cells. Several studies have shown that vitamin B3 may play a role in angiogenesis and cancer growth. Some studies suggest that vitamin B3 can stimulate angiogenesis, potentially leading to increased tumor growth. On the other hand, other research has demonstrated that vitamin B3 may have an inhibitory effect on angiogenesis, which could reduce cancer growth. It is important to note that the relationship between vitamin B3 intake, angiogenesis, and cancer growth is complex and may depend on various factors such as the concentration of vitamin B3, the type of cancer, and individual health conditions. In general, it can be stated that the link between vitamin B3 intake, angiogenesis, and cancer growth is not yet fully elucidated, and further research is needed to gain a clearer understanding of the specific mechanisms and effects 10 Reply 3 replies @michaelransom5841 @michaelransom5841 4 months ago (edited) Great video... I'm also taking niacin as opposed to NMN or NR simply because of the cost factor. It's hard to justify NMN or NR at nearly $1-2 for 500mg vs a whopping 3cents for 500mg of niacin. and considering i personally take 1500mg of nicotinic acid a day, putting up with a little bit of flushing doesn't seem like such a big deal! Yes, 1500 mg/day carries additional risks, but also the majority of the cholesterol benefits are typically only seen at dose above 1000mg/day, and I mitigate the risks... adequate choline (500mg/day min), inositol (500mg/day min) , folate (1000mcg/day min), b12 (1200mcg/day min), etc, get lots of protein in the correct amino acid ratios (including a roughly 3:1 intake of glycine to cysteine), don't drink, and take things like AKG, berberine, astragalus, apigenin, psyllium husk, etc. to help support blood sugar levels, insulin sensitivity, and support my kidney's and liver, including ensuring the correct ratio of iron copper and zinc in my diet, while never taking any of those together in supplement form, and when takin as a supplement, always as an amino acid chelate or else strictly from food (naturally chelated), and never taking vitamin C with iron or copper.. (the list goes on and on.. lol). Now, about the last part of your video, although 2 gr a day of tryptophan should be tolerable, I do have a few concerns. As I am sure you are aware, an imbalance of amino acids can be just as detrimental as an insufficiency, and it sounds like you are already getting more than twice the adequate intake for tryptophan for an individual of your size, roughly in line with myself. Adequate intake is roughly 5mg/kg/d. Also, to maintain proper ratios, intake should be roughly 0.4x Histidine (I use histidine as the reference line due to the relatively high potential for toxicity, relative to the other amino acids. Generally if you are consuming safe levels of histidine, and you are getting all other amino acids in the correct ratios, all the other amino acids will also be within their respective tolerable upper limits. ) . I am roughly 90kg, so using myself as a baseline, an adequate intake should be just 450mg/d. I personally average around 1200mg/d, nearly 3 times the adequate intake, but well within the UL of 6gr/day (this UL may be a bit too high as the risk of serotonin syndrome and other side effects seems to increase significantly past 4.5gr/day). If you are already getting roughly 1000mg/day, it is HIGHLY unlikely that this is a limiting factor for you as this is well in line with my own intake, and I get a minimum of 110-150gr/day of combined amino acids from all sources, and I go out of my way to ensure proper ratios. (I take a base of whey concentrate and collogen peptides to help stay on target, but tweak things based on the reported content of the foods I eat each day). All that said, 2 grams is well below the UL, and well below the 4.5gr/day level associated with increased risk of side effects, so I'm not particularly concerned about the risk from consuming that much tryptophan per say, I just thought yo should be aware that 1. it's unlikely to make a large difference given your current intake, and 2. that it is important that you increase the remainder of your essential amino acid intake accordingly to avoid issues with amino acid imbalance. The last thing any of us want is you making yourself sick... otherwise, super impressed with your videos and journey so far, keep up the great work! 22 Reply Conquer Aging Or Die Trying! · 14 replies @KMSid21 @KMSid21 4 months ago Another great video Michael. Like others have mentioned in the comments, would it be possible to add some comments to them detailing how you feel these changes affects you. I know it is subjective but it would be interesting to see how the changes affect you on a day-to-day basis. 3 Reply Conquer Aging Or Die Trying! · 1 reply @pureffm @pureffm 4 months ago (edited) Michael, I am interested in how you have been feeling at each level of NAD. The blood NAD levels are one thing, but how does it correlate with your overall well-being? One thing for me I have noticed is that NMN really make me too tense compared to my NR/NMN/NAD combo. Both make me indifferent to cold, as my body becomes a heat engine. And Niacin usually makes me more relaxed and my muscles feel more oxygenated, less tense. I also have NAD only supplements that will try soon. My doses are usually small but I find that I react strongly to even 150mg of any of those! When I was on B3 at high (250) dose for over a week I developed peripheral neuropathy, so I think it had an effect on my nerves, maybe because I was missing some other B vitamins (rlatively speaking). I have a very high testosterone levels for my age, so it is possible NAD or NMN is not the best for me. I should really get my NAD levels tested to find my baseline. 6 Reply Conquer Aging Or Die Trying! · 7 replies @iakona23 @iakona23 4 months ago Wow, great data and a concise explanation. Thank you so much. 13 Conquer Aging Or Die Trying! Reply @photo200 @photo200 4 months ago (edited) Great video, just subscribed. With the movement afoot to pull nmn from the market, I've been expecting to see increased interest in other pathways, and it's great to see some real-life comparison data on a pathway that doesn't involve taking nmn. EDIT: Just saw the pinned comment, sounds like this isn't the salvage pathway. Personally, I've been using a combination of nmn (while it's still available) and nicotinamide (not NA), but haven't done any blood tests. That's probably the next step. 3 Conquer Aging Or Die Trying! Reply Conquer Aging Or Die Trying! · 2 replies @joel402 @joel402 2 months ago Is it possible that there is a lot of variability in the test to get your NAD levels? It would be worth doing a series of blood tests at different times of the day in the control phase just to see what the variance is. Without knowing it, it is possible that one might make decisions just based on noise. Reply @akadaka-oc9kq @akadaka-oc9kq 2 months ago This is amazing! Thank you for sharing your tests. I wish I could test mine too. 1 Reply @_FightForYourFreedom_ @_FightForYourFreedom_ 1 month ago Very clearly explained. Thanks for the thorough testing and reporting! 1 Conquer Aging Or Die Trying! Reply Conquer Aging Or Die Trying! · 1 reply @reinerheiner1148 @reinerheiner1148 4 months ago The most common cause for reduced nad with aging is because of cd38. Reduced de novo synthesis probably does not play a big role. Its great to see your different nad test results compared to each other, with intervention. I would not have guessed that na is so much better than nmn. How strong is the niacin flush effect for you? 3 Reply Conquer Aging Or Die Trying! · 8 replies @scotthamann1476 @scotthamann1476 4 months ago Great videos! There have been a few other similar questions but I'm curious to know why you've chosen not to supplement with betaine or TMG? (Since TMG lowers homocysteine and provides the needed methyl donors for the niacin to be processed.) 1 Reply Conquer Aging Or Die Trying! · 1 reply @cravarc @cravarc 4 months ago I always feel I can't wait for your next video. Every episode ends in a cliffhanger :) 14 Conquer Aging Or Die Trying! Reply Conquer Aging Or Die Trying! · 1 reply @petervafeades4095 @petervafeades4095 4 months ago Thank you for confirming my own conclusions; 1g of NMN had little or no effect, 500mg NA daily has a definitive effect on my energy levels. No flush with 500mg, just a bit of warming lower jaw and/or forearms. Reply @user-vw3zd2jp3d @user-vw3zd2jp3d 4 months ago Very useful. It will be interesting to see the results of going over 600 mg of niacin per day. Does it increse NAD further or is 600 mg a point of salvage pathway saturation. How does the dose-response curve look. Exciting stuff! 4 Conquer Aging Or Die Trying! Reply 3 replies @catman4471 @catman4471 4 months ago To be honest I don't get the same effects from Niacin unless I take doses in excess of 2g which causes an incredible flush and might be damaging to the liver with regular high doses.. NMN has proved to be the best NAD pre-cursor for me. On another note: I'm wondering if there is some 'back talk' from NMN to Tryptophan or if there could be another molecule along the Kynurenine pathway that interferes with the body's ability to create NAD, because if I don't get a good sleep the nmn is less effective? 1 Reply 1 reply @espinosalexis @espinosalexis 4 months ago (edited) What about Nicotinamide (B3)? I realised that my B3 bottle says Nicotinamide instead of Niacin. Could you perform a test with Nicotinamide? Or, if you already know from literature, can you talk about the difference in terms of NAD increase in the body? Also, this experiment and report is amazing, thanks a lot! 2 Conquer Aging Or Die Trying! Reply Conquer Aging Or Die Trying! · 4 replies @thenana3792 @thenana3792 4 months ago I'm 23 and getting my midlife crisis done early. I really am hyper fixated on improving my overall health and slowing or halting the aging process. When I get the money, I would like to check out my NAD+ content as I was taking some exogenous NAD+ supplements for a short while, but have in the last 4-5 months done intermittent fasting and keto, which according to anecdotal testimonies seems to increase NAD's. Lately I've been doing a 2 day fast on weekends to enter a short term autophagy. I'm monitoring all my health metrics including blood ketone level daily to make sure I'm staying in good health as well. My hope is that I can get in great shape and then do whatever I can to stop aging. I've lost nearly 70lbs over the past 2 years and 30 of those were the last 4 months. I've gained more muscle and lost more fat than I ever have, which leads me to wonder if there is a way to check my myostatin levels. My understanding is that myostatin increases with age, but can be remedied for a short while through exercise and muscle development, but there may be specific antogonists for it entering the medicine scene soon. Reply 3 replies @helenmckay3260 @helenmckay3260 4 months ago Michael, Did you test your homocysteine levels whilst on Niacin supplementation? noticed in the past that you mentioned Niacinamide can increase homocysteine levels. I have muscle myopathy and stopped taking Niacinamide because I was worried about my homocysteine levels being too high (25.36 mull/L). Thank you. 4 Reply Conquer Aging Or Die Trying! · 2 replies @friedux2065 @friedux2065 4 months ago My main concern with such a high NA dose is its methyl group stripping action which could result in higher homocysteine among other things. But since you take TMG its probably not a concern. How did you tolerate the crazy flushing from that high of a dose? 4 Reply Conquer Aging Or Die Trying! · 3 replies @jefflittle8913 @jefflittle8913 4 months ago Re: grape seed powder and NAD. Grape seed powder is supposed to be one of the more effective senolytics. It wouldn't be shocking at all if an effective senolytic decreased NAD levels in the bloodstream because you would need to pull NAD into the cells for this and that would be a good thing. 2 Reply Conquer Aging Or Die Trying! · 1 reply @MrEtc31265 @MrEtc31265 4 months ago Michael, thank you for sharing as always. I have a question. Did compare your cholesterol numbers before and after taking Niacin? 1 Reply Conquer Aging Or Die Trying! · 2 replies @thezquad @thezquad 4 months ago Thanks again doc. I've been taking 50mg niacin daily for years but never thought of taking that much. How do you feel not that your NAD concentration doubled? 1 Reply Conquer Aging Or Die Trying! · 1 reply @amritrosell8561 @amritrosell8561 4 months ago Great video and love the attention to detail! Have you tried anything for CD38 like luteolin, apigenine or rutin? Have you checked what happens with NADPH if you increase Pregnenolone? Reply Conquer Aging Or Die Trying! · 3 replies @weiminyang7206 @weiminyang7206 4 months ago Great! I'm wondering if you consider NMN to be subject to degradation by CD38, but Nician. Thank you, Michael, for your informative information 4 Reply Conquer Aging Or Die Trying! · 6 replies @pettersbrevlada @pettersbrevlada 3 months ago Thank you for your detailed walkthroughs! Do you think there are differences in form of niacin? Nicotinic acid vs nicotinamide? Reply Conquer Aging Or Die Trying! · 1 reply @eyera18901865 @eyera18901865 4 months ago Michael, I have been telling you about high dose niacin for months. Please acknowledge me. I have done this with jinfiniti years ago. You would be well advised to read Saul's latest book on Niacin. Also, I think if you repeated your methylation age test after being on high dose niacin ( a methyl consumer) you will likely find a massive change. That is no reason to stop it however. 3 Reply Conquer Aging Or Die Trying! · 5 replies @berdi4berdi4 @berdi4berdi4 4 months ago Thanks! That's just what I wanted to know. How Niacin impacted on your NAD levels. 1 Reply @orion9k @orion9k 4 months ago I take 500 mg per day and it literally gives me a feel of burns my skin like cold plunge after sauna, but I feels like my mind and body is alive on a whole new level, it's the weirdest supplement of them all but also my favourite supplement. I wish I could let other people try it but I am scared of their reactions to it, some people literally get panic attacks after taking NA even thou the red skin flush is completely safe. 5 Reply 4 replies @Telecom515 @Telecom515 3 days ago Thanks for your excellent presentation as always. I have a question regarding the mechanics of niacin. For instance, if you have high phosphorus and high blood glucose and then you take niacin, will it reduce the phosphorus level and blood sugar level in your body? Dr Sinclair said that niacin will look to bond with a sugar molecule and a phosphorus module to form NMN. If this is the case, will it be good for people with high blood sugar level and high phosphorus level to take niacin because it will reduce the levels of these 2 markers? Reply Conquer Aging Or Die Trying! · 1 reply @stephenromey6348 @stephenromey6348 3 months ago Does anyone know of what the daily dose range would be for converting nicotinic acid to NAD? Does it matter whether it is one large dose or 2-3 divided doses throughout the day? I am convinced that this is a viable supplement for NAD, but of course, getting the optimal dose may be problematic. If anyone has done this and had their NAD tested, it would be interesting to hear your results and the dosing of nicotinic acid you used. I am currently doing 600mg a day of nicotinic acid @ 200mg X 3/day. Reply Conquer Aging Or Die Trying! · 2 replies @Schu2505 @Schu2505 4 months ago Interesting confirming results. I recall reading that study and wondering why I was spending so much money on NR. I think you’ll enjoy the interviews with Nuchido’s founder and their study. The study shows that niacinamide worked better than NR. Their formula contains common ingredients that energize the required enzymatic reactions as well as niacinamide. 2 Reply Conquer Aging Or Die Trying! · 2 replies @knightblade87x @knightblade87x 4 months ago Do you have a take on CoQ10? I'm always told that it has an effect on mitochondrial health. Reply @rkpell11 @rkpell11 4 months ago Super awesome and exciting news! I know it's subjective but curious how you feel now that your NAD levels have more than doubled? 1 Reply Conquer Aging Or Die Trying! · 1 reply @sinocelt @sinocelt 4 months ago (edited) I took 500 mg of niacin twice a day for months (or even years) and seem to have more energy since I stopped, though considering all the other factors that changed in my life and supplementation, it's probably a coincidence. Another possibility, though, is that I should have taken TMG with the niacin. I'll try that. I'd actually already ordered some niacin and TMG before this video was posted, to take advantage of a Vitacost sale. I've ordered some P5P and methylcobalamin at the same time. Reply 2 replies @jeagr209 @jeagr209 2 months ago Have you considered that maybe your body tries to stay in homeostasis, and so slowly adjusts your metabolism to bring NAD levels back to what is needed, vs what is desired? Reply Conquer Aging Or Die Trying! · 1 reply @espinosalexis @espinosalexis 4 months ago (edited) How are you controlling the amount of methyl-donors? Siim Land (record man in minimal aging rate) recommends the supplementation with TMG when using NMN. So, I guess the same would apply when supplementing with Niacin to boost NAD. This seems to be very important. I know you prefer to provide them with whole foods. But have you tracked this? How would you know you have enough methyl-donors and wont need to supplement with TMG or similar? Thanks. Also, what is your age measured with DNA-methylation estimators? I think you should put your name in Brian Johnsons list of the Rejuvenation Olympics. 2 Reply @shgj1 @shgj1 4 months ago (edited) Can you make a video summarizing what has worked to improve blood markers. Or daily diet. Further, did you ever try supplementing with HA orally (hyaluronic acid). Would be a great test. I am on 2x500mg niacin, 2x500mg HA, 2x1g taurine, 2x(2x 600mg nac with selen), daily b complex, and all that has helped me drop triglycerides that have been for over a decade 500+ to normal levels. Crp is below lab measuring scale (most of the time). Troponin l-hs below measuring scale. Other markers are remarkably good too. 24 hr ecg/ekg was excellent. Hb a1c 4.9. That list for me is just a must. I have my parents (70s) on the same they have improved tremendously, you should consider at least some supplements. Reply 1 reply @michael-qp9xd @michael-qp9xd 4 months ago Michael - very interesting work here. Wondering with big jump in NAD did you notice having more energy as NAD important for mitochondria the batteries of cells. As you have dedicated exercise program where think you are doing pull-ups - with jump in NAD were able to do more number of pull-ups? And with blood check - which cells of blood are the NAD increasing in - red blood cells maybe? Important probably for NAD is to boost in muscle cells but here to check need a muscle biopsy which uncommon. Are there reports or studies where did with patients both blood and biopsies to check correlations as to if increase in blood also increase in muscle cells? .Thank you for all work and efforts here. 2 Reply Conquer Aging Or Die Trying! · 1 reply @SportsIncorporated @SportsIncorporated 4 months ago Thanks. Wished you had told people about the Niacin flush, or to stay away from a kind of timed release Niacin, or effects taking this stuff might have on the liver. 3 Reply Conquer Aging Or Die Trying! · 1 reply @tomasnielsen5132 @tomasnielsen5132 4 months ago Interesting. I'm on 500mg Niacin since a year or so for other studies I've read. But this kind of enforces my belief to continue. 2 Reply Conquer Aging Or Die Trying! · 3 replies @Hail2MasterChief @Hail2MasterChief 4 months ago Really enjoy your relentless pursuit of your N1 goals. Conquer Aging Or Die Trying! Reply Conquer Aging Or Die Trying! · 1 reply @guuseh2918 @guuseh2918 4 months ago Great video as usual. Pls keep them coming. But I recall your video a few years ago https://www.youtube.com/watch?v=y6joAp_UghQ. Will Niacin increase homocysteine levels similar to Niacinamide as indicated in your earlier video? And based on this earlier video, can one infer that it is more efficient to pair NAD precursors with B12 (as methyl group donor) rather than TMG (which is what seems to be recommended by most 'experts'). It might be that the more effective your NAD precursor is (in synthesizing NAD), the more the increase in Homocysteine. Are you still tracing your Homocysteine? It would be great if you could share the corresponding Homocysteine levels with the increase NAD levels. Many thanks. Reply Conquer Aging Or Die Trying! · 2 replies @nailb0y @nailb0y 1 month ago Hi, Do you think Niacinamide could decrease Sirt1? As I have read some studies shows that niacinamide is a Sirt1 inhibitor only in vitro but an activator in vivo. Niacinamide does a good job at increasing NAD+ levels. The only problem is that decreases Sirt1, thats why we have all the hype with NR and NMN Reply Conquer Aging Or Die Trying! · 1 reply @adamd9418 @adamd9418 4 months ago I'll be curious to see if you are able to increase your DHEA levels. My guess is no since I think your regime qualifies as being calorie restricted and this seems to down regulated growth pathways, but I would love to be proven wrong. 2 Reply Conquer Aging Or Die Trying! · 1 reply @9kilsyth @9kilsyth 2 months ago Excellent work. Have you tried NR? I take Niacin so you information was helpful and reassurring. Reply Conquer Aging Or Die Trying! · 1 reply @KoiRun50 @KoiRun50 4 months ago How was your energy level and exercise performance with an NAD of 19.9 uM? 7 Reply Conquer Aging Or Die Trying! · 1 reply @gracious1498 @gracious1498 2 months ago Michael very informative video.new subscriber here.just started b3 in a flush form 1week ago in the morning so far seeing a surge in energy and my memory is becoming sharp that's what i noticed less episode of forgetfulness. i would like to ask can i continue taking pregnenolone 10mg i usually take at night(started two weeks ago).37 YO female here Reply @creightonfreeman8059 @creightonfreeman8059 4 months ago Maybe your CD38 enzyme is high. Have you tried taking Apigenin to block CD38 to see if that has any effect on NAD levels? 2 Reply Conquer Aging Or Die Trying! · 1 reply @MichaelCzajka @MichaelCzajka 3 months ago Have you tried the same thing using inositol hexanicotinate? Inositol hexanicotinate is the slow-release form of niacin. Inositil hexanicotinate works better than other forms. :-) 1 Reply Conquer Aging Or Die Trying! · 1 reply @littlesamoan92 @littlesamoan92 4 months ago Some people go up to 5g of niacin - i am interested to see what improvements there are going toward that dose 2 Reply Conquer Aging Or Die Trying! · 3 replies @danno1800 @danno1800 4 months ago (edited) You did an OUTSTANDING JOB! Thank you — much appreciated…I have SUBSCRIBED!!! 2 Conquer Aging Or Die Trying! Reply @seanolivas9148 @seanolivas9148 4 months ago You're nmn test hypothesis was missing the idea of adding more methyl donors in the salvage pathway. Tests show adding TMG will help greatly 1 Reply Conquer Aging Or Die Trying! · 1 reply @etielahat9414 @etielahat9414 4 months ago As always, fantastic info. Thank you for sharing. I'd also be interested in the niacin brand, and is it a no flush like sogar has. 2 Reply Conquer Aging Or Die Trying! · 2 replies @sgill4833 @sgill4833 4 months ago For me b1 plus Nam give me a huge boost. Nmn gives me chest anxiety. 1 Reply @michael-qp9xd @michael-qp9xd 4 months ago Michael - mentioned much are side effects of high levels of niacin at just 50mg/day below. You mention going to 600 mg/day - any concerns at this very high level? Side effects may include diarrhea, headache, stomach discomfort, and bloating. High doses (50 mg or more) of niacin can cause side effects. The most common side effect is called "niacin flush," which is a burning, tingling sensation in the face and chest, and red or flushed skin. 1 Reply Conquer Aging Or Die Trying! · 1 reply @tonipieleanu @tonipieleanu 4 months ago 600mg of niacin wow. Would be interesting to check what happens to your methylation, specifically homocysteine 2 Reply Conquer Aging Or Die Trying! · 1 reply @justsaying7065 @justsaying7065 4 months ago This just goes to show that there’s no need to waste money on NR and NMN, which are very expensive. Good old nicotinic acid works and niacinamide should too. Both are super cheap. I switched from NR to niacinamide earlier this year. 3 Reply Conquer Aging Or Die Trying! · 7 replies @seekfactsnotfiction9056 @seekfactsnotfiction9056 2 months ago Your topics are very important academic data, could you please invest good audio so that we can hear you better? Thank you sir for your great research Reply Conquer Aging Or Die Trying! · 1 reply @drednac @drednac 4 months ago I take 500mg daily. Good to see it works for somebody else. 1 Reply @Daltarakis @Daltarakis 4 months ago Great video once again. I would like to ask if you have any concern about the diabetic effect of niacin 3 Reply Conquer Aging Or Die Trying! · 5 replies @adalllah @adalllah 4 months ago Amazing methodology 🎉 4 Conquer Aging Or Die Trying! Reply @barrie888 @barrie888 2 months ago fascinating biochem , and well presented, tks 1 Reply @Seeker_of_sense @Seeker_of_sense 4 months ago You might have blocks on different levels, so perhaps combining the supplements would work. 1 Reply Conquer Aging Or Die Trying! · 1 reply @elliottrubenstein1746 @elliottrubenstein1746 4 months ago Thanks appreciate your hard work and sharing. 5 Conquer Aging Or Die Trying! Reply @AT-xl9db @AT-xl9db 4 months ago This is amazing!!! 😊👍 2 Conquer Aging Or Die Trying! Reply @WellnessMessiah @WellnessMessiah 2 months ago I've just found your channel. keep up the good work! just subscribed😊 1 Reply Conquer Aging Or Die Trying! · 2 replies @surfreadjumpsleep @surfreadjumpsleep 2 months ago (edited) ok i wanted this NAD boost. bought some nicotinic acid 500mg. holy heck. this stuff turns my skin on fire. even at half dose with food. walmart sells a non flushing version which is another formulation (not nicotinic acid). Any idea if that'll also work to boost NAD? Or would an extended release maybe work better? Reply Conquer Aging Or Die Trying! · 2 replies @TheJasonHowarth @TheJasonHowarth 4 months ago Great result! 4 Conquer Aging Or Die Trying! Reply @juuskanda @juuskanda 3 weeks ago i appreciate this but I can get flushing at 50mg! I will try again to work up slowly. if anyone has advice to counter flushing please reply with it Reply @machyman1189 @machyman1189 4 months ago Michael, In the video, you said you took the nicotinic acid form of niacin instead of niacinamide. Do you expect the results to be the same for both forms of vitamin B3? Reply Conquer Aging Or Die Trying! · 1 reply @willbrink @willbrink 3 months ago I'm still waiting for the comparative studies of cheap niacin vs NR or NMN. 1 Reply Conquer Aging Or Die Trying! · 1 reply @enricopuno8276 @enricopuno8276 3 months ago How about lowering the CD38 like combining Niacin with Apigenin? I think the cheapest will be dried parsley. Reply Conquer Aging Or Die Trying! · 1 reply @keithschmolze7653 @keithschmolze7653 4 months ago Interesting stuff. Which Niacin supplement did you use? 1 Reply Conquer Aging Or Die Trying! · 2 replies @HuyHuynh-qt1fx @HuyHuynh-qt1fx 2 months ago Michael, Does Niacin increase Intracellular or Extracellular NAD+? I'd like to know, thank you very much! Reply Conquer Aging Or Die Trying! · 2 replies @bowser2005 @bowser2005 3 months ago Cool thing about niacin is it's super cheap, yes it can cause flushing but that goes away with use. If the flush really bothers you take it with applesauce, in studies (you can find in google scholar) applesauce helps reduce the flushing just as well as aspirin. Reply @ptaylor3352 @ptaylor3352 4 months ago Have you tried Nicotinamide to see if it increases NAD? 1 Reply Conquer Aging Or Die Trying! · 1 reply @earx23 @earx23 2 months ago So Niacin gave better results than NMN? But I thought Niacin was metabolized into a toxic chemical, which causes an allergic reaction? Does it also give the mood boost of NMN? Reply Conquer Aging Or Die Trying! · 1 reply @TheBroSplit @TheBroSplit 4 months ago How are you feeling with higher Nad levels? 1 Reply Conquer Aging Or Die Trying! · 1 reply @matttee1319 @matttee1319 4 months ago Fascinating! Great stuff. 2 Conquer Aging Or Die Trying! Reply @MindBodyStudio @MindBodyStudio 4 months ago Thank you so much for this video. I am going to test my NAD levels and switch if nmn is not working for me. 2 Conquer Aging Or Die Trying! Reply Conquer Aging Or Die Trying! · 4 replies @domik1983 @domik1983 2 months ago what will be better niacin or niacinamide (no flush b3?) Reply @shimondoodkin @shimondoodkin 4 months ago Did you feel the same with niacin like if you were taking NMN? Reply Conquer Aging Or Die Trying! · 3 replies @ivanandreevich8568 @ivanandreevich8568 4 months ago Which version of niacin are you taking - the flush version or the non-flush version? 1 Reply Conquer Aging Or Die Trying! · 1 reply @justsaying7065 @justsaying7065 4 months ago How much were the increase in HDL and the reduction in BP from taking 600mg nicotinic acid? Reply Conquer Aging Or Die Trying! · 3 replies @mahmodali9394 @mahmodali9394 4 months ago Great video 👌 3 Conquer Aging Or Die Trying! Reply @michael-bell @michael-bell 3 weeks ago So does this mean a person can take flushing-type niacin at proper doses and expect many of the same longevity and youth-restoring benefits that people are getting from NMN? Reply Conquer Aging Or Die Trying! · 2 replies @orion9k @orion9k 4 months ago If you have low DHEA isnt that also related to having low testosterone levels? Perhaps you should try supplements that boosts testosterone or take something that boosts DHEA. 1 Reply Conquer Aging Or Die Trying! · 2 replies @brentvan488 @brentvan488 4 months ago Promising news! What brand and dosing schedule are you using for the Niacin? 600 mg at one time or spread over the day? Do you get Niacin flushes? 2 Reply Conquer Aging Or Die Trying! · 1 reply @jeffrey4577 @jeffrey4577 3 months ago Outstanding 😊 1 Reply @dermatologymiami @dermatologymiami 4 months ago Awesome information thanks 1 Reply @jackbuaer3828 @jackbuaer3828 4 months ago (edited) I guess I am going to rain on the Niacin parade, just as I have done with other NAD boosters in the past. I think people should be aware that we already have a wealth of data on Niacin supplementation and the data that I have seen does not seem to be compelling. I provide some snippets of studies below. I am curious as to whether niacin may have negatively affected any of your other biomarkers ( e.g., blood glucose, homocysteine, liver enzymes) or improved other biomarkers. I am on a daily dose of 50 mg niacin. I am a bit wary of a going higher in Niacin. Regardless of whether Niacin raises NAD or not, the evidence for Niacin supplementation (from a mortality standpoint) does not seem to be great. If Niacin supplements generally increase NAD, that NAD increase does not appear to do that much for health in studies. "Results: During the screening phase, titration of niacin dose from 100 mg to 1000 mg daily resulted in a 17% increase in mean plasma homocyst(e)ine level from 13.1 +/- 4.4 micromol/L to 15.3 +/- 5.6 micromol/L (P <.0001). At 18 weeks after randomization, there was an absolute 55% increase from baseline in mean plasma homocyst(e)ine levels in the niacin group and a 7% decrease in the placebo group (P =.0001). This difference remained statistically significant at the end of follow-up at 48 weeks." Garg R, Malinow M, Pettinger M, Upson B, Hunninghake D. Niacin treatment increases plasma homocyst(e)ine levels. Am Heart J. 1999 Dec "Using available cases, niacin did not reduce overall mortality (risk ratio (RR) 1.05, 95% confidence interval (CI) 0.97 to 1.12; participants = 35,543; studies = 12; I2 = 0%; high‐quality evidence), cardiovascular mortality (RR 1.02, 95% CI 0.93 to 1.12; participants = 32,966; studies = 5; I2 = 0%; moderate‐quality evidence), non‐cardiovascular mortality (RR 1.12, 95% CI 0.98 to 1.28; participants = 32,966; studies = 5; I2 = 0%; high‐quality evidence), the number of fatal or non‐fatal myocardial infarctions (RR 0.93, 95% CI 0.87 to 1.00; participants = 34,829; studies = 9; I2 = 0%; moderate‐quality evidence), nor the number of fatal or non‐fatal strokes (RR 0.95, 95% CI 0.74 to 1.22; participants = 33,661; studies = 7; I2 = 42%; low‐quality evidence). Participants randomised to niacin were more likely to discontinue treatment due to side effects than participants randomised to control group (RR 2.17, 95% CI 1.70 to 2.77; participants = 33,539; studies = 17; I2 = 77%; moderate‐quality evidence). The results were robust to sensitivity analyses using different assumptions for missing data. Schandelmaier S, Briel M, Saccilotto R, Olu KK, Arpagaus A, Hemkens LG, Nordmann AJ. Niacin for primary and secondary prevention of cardiovascular events. Cochrane Database Syst Rev. 2017 "Overall, the evidence indicates that nicotinic acid supplementation improves blood lipid profiles but has no significant effects on risk of cardiovascular events." Niacin, Fact Sheet for Health Professionals, NIH The above point made by the NIH seems to indicate that improving biomarkers does not always mean an improvement in health. "According to our study, higher dietary niacin intake was associated with lower mortality in cancer patients. Niacin supplements improved cancer survival rates, but not all causes of mortality." Ying, H., Gao, L., Liao, N. et al. Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort. BMC Cancer 22, 1173 (2022) " Niacin in doses above 500 mg daily causes transient, asymptomatic elevations in serum aminotransferase levels in up to 20% of people. The elevations are rarely greater than 3 times the upper limit of the normal range and usually resolve spontaneously even with continuation of the drug." LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Niacin. [Updated 2020 Jul 9] I did see one old study with a mortality benefit with Niacin, but this does not seem to jive with the Cochrane Review above or a later AHA review that I viewed, but did not cite above: " Mortality in the niacin group was 11% lower than in the placebo group (52.0 versus 58.2%; p = 0.0004). This late benefit of niacin, occurring after discontinuation of the drug, may be a result of a translation into a mortality benefit over subsequent years of the early favorable effect of niacin in decreasing nonfatal reinfarction or a result of the cholesterol-lowering effect of niacin, or both. Paul L. Canner, Kenneth G. Berge, Nanette K. Wenger, Jeremiah Stamler, Lawrence Friedman, Ronald J. Prineas, William Friedewald,Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin, Journal of the American College of Cardiology,Volume 8, Issue 6, 1986,Pages 1245-1255 6 Reply Conquer Aging Or Die Trying! · 3 replies @lawnmower11 @lawnmower11 4 months ago (edited) Subbed. Very interesting. Nicotinamide should be same as Niacin aka nicotinic acid, correct? Same mg for nicotinamide as niacin too? 1 Reply Conquer Aging Or Die Trying! · 5 replies @charlesax8140 @charlesax8140 2 months ago I'm 76 years old, I supplanted with 1000mg of nmn, 1000mg of niacin, 600mg of nr, and CD 38 surpresers, apigenin 1000mg, quercetin 1000mg, my nad level was 119 um. Reply Conquer Aging Or Die Trying! · 2 replies @bowmastah5169 @bowmastah5169 4 months ago Is nicotinamide or niacinamide sufficient for nad? Or does it have to be niacin? 1 Reply Conquer Aging Or Die Trying! · 1 reply @jp7357 3 months ago I heard an interview with Charles Brenner ? Where categorically stated that plasma icnad was not a reflection of NAD+ … he said that a liver biopsy was needed … Reply Conquer Aging Or Die Trying! · 1 reply @alyousuf @alyousuf 3 months ago Are you taking instant release Niacin or extended/sustained release. i ask because it seems that extended release versions are purported to be hepatotoxic. 1 Reply Conquer Aging Or Die Trying! · 2 replies @urielstud @urielstud 4 months ago I can do 50+ mg of Source Naturals regular flushing Niacin without any flushing side effect. I guess i need to do it 10-12 times per day to get you 600 mg dose. 3:15 Reply @sooooooooDark @sooooooooDark 4 months ago (unrelated to the video but rather post it here than when i find a more appropriatedly themed video of urs and having it forgotten until then 😂: ) have u come across associations between fatty acid ratios in ur data (other than the commonly known omega 3:6) that implicate better health outcomes? id be especially interested in ALA:omega 6 (so total omega 3 minus dha/epa: LA) as well as the totality of all ratios between the different types of fats (possilby in the light of how abundantly they r found in human tissue (?) in an optimal scenario) so instead of the omega 3:6 id be curious about ur omega 3:6:9(/7):satfat ratio what u consider best following the data Reply Conquer Aging Or Die Trying! · 1 reply @LandonPark @LandonPark 4 months ago Best TV series I’ve ever watched! Conquer Aging Or Die Trying! Reply @surfreadjumpsleep @surfreadjumpsleep 4 months ago Does Niacin boost homocysteine? Sounds like an easy win otherwise. Though are you saying it's not a win because it's not boosting the DHEA-S? 1 Reply Conquer Aging Or Die Trying! · 5 replies @squarz @squarz 4 months ago Good news it seems you found a way to increase NAD, bad news it seems there is no way to do that without supplements... 2 Reply Conquer Aging Or Die Trying! · 5 replies @cgprelude @cgprelude 4 months ago Did you use the flushing or no -flushing form of niacin? 1 Reply Conquer Aging Or Die Trying! · 2 replies @shimondoodkin @shimondoodkin 4 months ago Fruitful video. Good Conquer Aging Or Die Trying! Reply @siasina @siasina 4 months ago I wonder if this would work with the non-flushing version?? 3 Reply Conquer Aging Or Die Trying! · 5 replies @RickLindstrom @RickLindstrom 4 months ago The two charts at 4:21 seem to suggest that the controls outperformed the intervention group. Are the controls really grey or was that a color mixup? Reply Conquer Aging Or Die Trying! · 2 replies @jp7357 @jp7357 4 months ago I thin I read that the endocrine system gets its cholesterol from HDL cholesterol not LDL cholesterol Reply @mahmodali9394 @mahmodali9394 4 months ago Could alpha lipoic acid raise NAD through AMPK !! What’s your thoughts 1 Reply Conquer Aging Or Die Trying! · 1 reply @Me-mv9bz @Me-mv9bz 4 months ago I subscribed just because it is the most clever name for a YouTube channel I heard of. 1 Reply @sinocelt @sinocelt 4 months ago Ah! Great! I'd been waitng for that one. 😄 2 Reply 2 replies @Marco-rk9ye @Marco-rk9ye 4 months ago would niacinamide have the same effect in increased nad? 1 Reply Conquer Aging Or Die Trying! · 4 replies @ramonchavez937 @ramonchavez937 3 months ago Great stuff Conquer Aging Or Die Trying! Reply @Schutzmassnahmen @Schutzmassnahmen 4 months ago Astraxanthin is much better than grape seed powder Reply Conquer Aging Or Die Trying! · 2 replies @steelzmb4262 @steelzmb4262 3 months ago My skin was on fire at 450. 1 Reply @bbeautifullyU369 @bbeautifullyU369 4 months ago I'm confused.You are using Niacine to elevate NAD,when it's sayed bybother experts to take NMN. Reply Conquer Aging Or Die Trying! · 4 replies @imkiaj @imkiaj 4 months ago Any thoughts on Liposomal NAD+? Reply Conquer Aging Or Die Trying! · 1 reply @dirkheyer2297 @dirkheyer2297 4 months ago What about your measuring, maybe it is subject of a changing circadian rythm? Maybe one measurement in month, week, etc. ist not enough, maybe there is a lot of changing over 24h? Reply Conquer Aging Or Die Trying! · 1 reply @bad-ai-songs @bad-ai-songs 4 months ago All of this science is over my head. I'm just trying to figure out if taking cheap niacin will do as much or more for me than continuing to take expensive NMN. Reply Conquer Aging Or Die Trying! · 2 replies @lookfeelbehealthy6320 @lookfeelbehealthy6320 4 months ago Did I miss which type of niacin you took? Reply Conquer Aging Or Die Trying! · 1 reply @ebebei @ebebei 3 months ago Hi Michael, I’m looking for an affordable test to join the Rejuvenation Olympics. Please advise. Thanks! Reply Conquer Aging Or Die Trying! · 1 reply @kazuaenima @kazuaenima 1 month ago how about resveratrol? Reply @nomadic-lyfe9877 @nomadic-lyfe9877 4 months ago Forgive me, perhaps I missed it, what brand of niacin are you taking? 1 Reply Conquer Aging Or Die Trying! · 4 replies @tommyortiz6623 @tommyortiz6623 4 months ago Have you done self decode yet bud? It gives you specific recommendations Reply Conquer Aging Or Die Trying! · 1 reply @whiteninja9481 @whiteninja9481 4 months ago Please turn your mic volume UP. Been an issue for several videos now. Thanks! Reply Conquer Aging Or Die Trying! · 3 replies @livintnet @livintnet 4 months ago How did you took your niacin? All at once?. 600g all at once should had give you a big flush. 12 Reply Conquer Aging Or Die Trying! · 10 replies @iwdevelopers @iwdevelopers 3 months ago Hello, what form of niacin? Flush? Reply Conquer Aging Or Die Trying! · 1 reply @tomprovan50 @tomprovan50 4 months ago very interesting 1 Reply @davidl9554 @davidl9554 4 months ago What are your thoughts on NAM ? Reply Conquer Aging Or Die Trying! · 1 reply @tedschwartz2142 @tedschwartz2142 4 months ago WHERE TO BUY JUST NIACIN ?? Reply @johnlayton3456 @johnlayton3456 2 months ago what is NAD? Reply @carolmaplesden916 @carolmaplesden916 4 months ago What do you know about NAD+ IV Reply Conquer Aging Or Die Trying! · 1 reply @immortalityIMT @immortalityIMT 4 months ago Nice! 1 Reply @espinosalexis @espinosalexis 4 months ago How do you know that a NAD blood level of 30 is low? What is the range of optimal levels [minOptimal, maxOptimal] for a healthy active fit 30yo male? Without knowledge of this range your numbers mean nothing! Please report. Many thanks! 1 Reply Conquer Aging Or Die Trying! · 2 replies @matthewnovik5892 @matthewnovik5892 4 months ago Why not just take a DHEA supplement? 1 Reply Conquer Aging Or Die Trying! · 1 reply @tedschwartz2142 @tedschwartz2142 4 months ago BUT THIS NAD LEVEL DOES NOT MAKE US YOUTHFUL OUTSIDE AND WHAT ABOUT THE LINK I GAVE YOU ABOUT ALPHA LIPOLIC ACID DID YOUN WATCH IT ??? Reply @rickyida971 @rickyida971 3 months ago If Niacin increase NAD higher than NMN, NR , who will pay more to buy NR and NMN Reply Conquer Aging Or Die Trying! · 2 replies @cathystraka9531 @cathystraka9531 2 months ago in the blood not the muscle were its important Reply Conquer Aging Or Die Trying! · 1 reply @isa-manuelaalbrecht2951 @isa-manuelaalbrecht2951 4 months ago Niacin at this point was it * de- flushed* ??? I don't believe all I hear or read..😁🤣😉🤭😏 Reply Conquer Aging Or Die Trying! · 1 reply @edwardmallon4646 @edwardmallon4646 4 months ago Increasing the dosage into the one gram range may not be a good idea in the long run https://youtu.be/yEsPqB2bI6A?t=1109 1 Reply Conquer Aging Or Die Trying! · 1 reply @benv.5170 @benv.5170 3 months ago volume is too quiet Reply Conquer Aging Or Die Trying! · 2 replies @ukspawn666 @ukspawn666 3 months ago volume of this vid is very low (-20db) Reply Conquer Aging Or Die Trying! · 2 replies @thezquad @thezquad 4 months ago My comment keep getting deleted. There are flush free versions of niacin, why didnt you use a flush free version? 1 Reply Conquer Aging Or Die Trying! · 3 replies @ralfsigmund3491 @ralfsigmund3491 4 months ago First you should talk about the CV of the test if you know it. If not you should find out, if the CV is high then all yr presentation and trials are useless. 1 Reply Conquer Aging Or Die Trying! · 1 reply @Blurns @Blurns 4 months ago Why not just supplement DHEA? 2 Reply Conquer Aging Or Die Trying! · 2 replies @janmedlin2554 @janmedlin2554 3 months ago poor sound needs a voice over Reply Conquer Aging Or Die Trying! · 1 reply @bobmarshall3700 @bobmarshall3700 9 days ago Can you possibly add any more medical abbreviations or jargon? Some people still understand 5% of what you are saying................. Is NMN the 'longevity pill' we've been waiting for? Scientist and bio entrepreneur breaks it down The Honest Channel 58.6K subscribers Subscribe 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 . 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 K Share Thanks Clip Save 53,843 views Feb 5, 2023 #agereversal #longevity #antiaging NMN, NR or niacin, are a group of related supplements that scientists believe boost our levels of NAD, a coenzyme that’s present in every cell in our bodies and is essential to our health, energy and longevity. In this video, NMN Bio founder, Dr Elena Seranova, who has a Masters in Translational Neuroscience and a PhD in Stem Cell Biology and Autophagy, explains the difference between them and why she believes NMN is a major step forward in fighting some of the negative effects of aging on our bodies. #longevity #agereversal #antiaging Subscribe to my channel here https://www.youtube.com/c/TheHonestCh... Watch the follow up with Dr Seranova here • 'Age-reversing' supplements: What NMN... You can find out more about NMN Bio, with a 10% discount on supplements, using this link https://nmnbio.co.uk/discount/ClareJ Discount code is ClareJ MY SKINCARE ROUTINE LED Red Light Mask Use code CLARECB for 15% off https://go.shopmy.us/p-573882 LED Eye Perfector https://go.shopmy.us/p-1614940 Use code CLARECB for 15% off • Peptide power! Dramatic hair regrowth... Calecim Multi Action Cream Use code HONEST for 15% off https://go.shopmy.us/p-654801 • How No7 scientists struck upon 'break... I recommend No7 Future Renew Serum for a low-cost peptide-based alternative https://go.shopmy.us/p-1347235 VITAMIN C: Preferred vitamin C serums (I alternate between these two) Geek & Gorgeous C-Glow https://go.shopmy.us/p-717360 Medik8 C-Tetra Luxe Lipid Vitamin C Serum https://go.shopmy.us/p-1709966 BLUELENE • Scientist & Bluelene founder on the p... I use the Daily Moisturizer or sunscreen AM Get 10% off orders using code THEHONESTCHANNEL https://bluelene.com/?dt_id=329188 PLUS ADIPEAU: I used this successfully to support facial fat renewal for six months. • Adipeau facial fat renewal cream | 3-... Use the code HONEST20FOR2 to get a 20% discount off first-time purchases when ordering two bottles of Adipeau Active Face Cream and otherwise HONEST10 for 10% off orders https://adipeaucare.myshopify.com/pro... I use affiliate links on this channel which means if you choose to buy a product using one of my links I receive a small commission - thank you! : ) This video is not sponsored. You can find my commercial policy here https://www.youtube.com/@TheHonestCha... I've also written two fictional novels which you can check out here : ) From the Outside https://amzn.to/3L6TvrZ Polls Apart https://amzn.to/3olN7oP Connect with me on social media: / honestclare / clares_j / honestclare Edited by David at https://www.redfacilities.com Disclaimer: This video and all content on this channel is for informational purposes only and is not intended as medical advice and should not be treated as a substitute for medical advice. TIMESTAMPS: 00:00 Intro 02:24 Dr Elena's research and why she started a bio supplements business 08:13 How does NMN work in our bodies? 11:00 When NAD levels start to decline 14:28 What does it do for the skin? 18:00 How do different NAD boosters compare? 19:15 Is NMN better in powder or capsule form? 19:52 FDA decision on classification Chapters View all Transcript Follow along using the transcript. Show transcript The Honest Channel 58.6K subscribers Videos About 20:12 Can supplements increase our longevity? Which ones and why? Claudia Glows shares her regimen by The Honest Channel 5.5K views · 1 year ago License Creative Commons Attribution license (reuse allowed) 227 Comments rongmaw lin Add a comment... @ClassicCarCustodians @ClassicCarCustodians 3 months ago I was the same way. I felt the effects right away. From Renu by science and Do not age. 6 months into it now and I see all the amazing changes for the better. at 46, I feel better than I did in my 20's, not by NMN alone. good diet, weight training exercise and proper sleep is added to it as well. 2 Reply @lindajoy23 @lindajoy23 9 months ago (edited) Thank you Clare for your quality content ❤ The Universe seems to be messaging me about MNM & NAD precursors. I’m in Melbourne, Australia and our national broadcaster just aired a series called Searching For Superhuman which delved into this exact subject. The scientists interviewed were among the first to identify the role of NAD and they ALL agreed lowering HGH is crucial to cell health & cell longevity and recommended against Keto & high protein diets. Absolutely fascinating 🧐 14 The Honest Channel Reply The Honest Channel · 3 replies @davidmanning1724 @davidmanning1724 5 months ago I noticed after years of weight training and 2 rotater cuff injuries that after 6 weeks of NMN ( to go with prior quercetin and glucosamine) that I had no longer pain in my shoulders and the stiff big toe from a athletic injuring I can now BEND MY BIG TOE after 20 years since the injury! 5 The Honest Channel Reply The Honest Channel · 1 reply @michaelbeggs2013 @michaelbeggs2013 3 months ago I have been taking 900 mg of NMN every day for 4 months, as well as glycine and many other supplements. I don't work out but I do feel like I have more energy now and I may start going to the gym. NMN has also stopped my fingernails from breaking all the time, wounds seem to heal more quickly, and NMN has also turned my body hair from gray back to a more youthful brown. I am a 56 year old head shaver, and I decided to try growing my hair out again. I did this two years ago and my hair was white. Now my hair is growing in mostly brown except around my ears. I definitely will keep taking NMN. I tried taking TMG but it is much too caustic for my duoudenal ulcer, so I stick with glycine. I am still trying to figure out a good methylation supplement to give the NMN a boost. 1 Reply @59250em @59250em 9 months ago I am not sure that you can really fix an age of 25 y. old. I think it depends on person and his level of activity. As for myself, I practice bodybuilding for 32 years but I began to take NR at the age of 35. It has made a great difference in terms of energy, pump and endurance. Now, I am 50 and I take a moderate quantity of 500 mg of NMN a day. For me, it's certainly one of the best supplements I can take, with PQQ and CO Q10 as well. 10 Reply The Honest Channel · 1 reply @Nzp6959 @Nzp6959 5 months ago Being an OMAD- er,it promotes autophagy and taking NMN,TMG,BERBERINE,VIT C,MULTI VIT FEMALE.RESERVATOL ,Krill and multi minerals supplements everyday.I’m 64 years and feeling very energetic and happy in my skin 2 Reply @claudiaglows @claudiaglows 9 months ago Great interview Clare! You know I love my NMN. It is definitely a supplement I do jot want to be without. I even give it to Sam, my 13 year old dog, and can see such a difference in her stamina, energy and strength. 42 The Honest Channel Reply The Honest Channel · 14 replies @pubwvj @pubwvj 9 months ago Okay, I am that one person. I have experienced no decline in energy, stamina, speed or strength. I am 60. Genetics, perhaps. Healthy living and eating. And, I thought about this stuff in my teens and designed my life to stay very active. I have started NMN after reading about it so hopefully it will be beneficial. 8 The Honest Channel Reply The Honest Channel · 2 replies @user-qy2ii2ml7c @user-qy2ii2ml7c 9 months ago Love your Channel. You really discuss topics that are of the moment. Thanks 6 The Honest Channel Reply @anononnl @anononnl 9 months ago Absolutely fascinating! Thank you, Claire! 2 The Honest Channel Reply @k-vd3702 @k-vd3702 9 months ago Hi Clare, good info. I think if possible please interview Clint Ober. He’s the founder of Earthing. It’s a very interesting subject and I believe it’s very beneficial for everyone to know about this. Thank you Clare. 5 Reply The Honest Channel · 1 reply @dcostanzino @dcostanzino 3 months ago Gen x here. My nieces and nephews seem to have less energy than me. Either that, or they are just less motivated but I have noticed this trend with millenials. So I don’t know, I kind of feel better off than some of the younger ones. Having said that, I am always actively engaged in improving my health so perhaps I am reaping the benefits of my effort. 1 Reply @gma2039 @gma2039 9 months ago I live in the US and haven't heard of NMN before this interview. Very interesting. 7 The Honest Channel Reply @maryannsinopoli1751 @maryannsinopoli1751 9 months ago Your Guest is an amazing woman. Nice to hear from her, she is well informed with knowledge. Very good! The Honest Channel Reply @chiron3489 @chiron3489 5 months ago Im 72. Tak8ng NMN for 2 weeks and my knee joint pain is gone. First time in ten years. Hope for other improvenents. 3 The Honest Channel Reply The Honest Channel · 1 reply @nvb455 @nvb455 9 months ago This is becoming one of my favorite channels😊 7 The Honest Channel Reply The Honest Channel · 1 reply @danielwillover450 @danielwillover450 7 months ago That was a great interview I learned a lot of information 1 The Honest Channel Reply @melissahamm8122 @melissahamm8122 5 months ago NAD decline at age 28? I'm 63 and just now hearing about all this? 😢 I'm trying it anyway, I hope it's not too late for me. Great video 😊 2 Reply 1 reply @BeeLZBeeb @BeeLZBeeb 9 months ago Kind of depressing to hear I’ve been in decline for fifteen years already lol. I really have a long way to go. Sugar and smoking. Currently keeping a tally of the amount and trying to reduce, drinking green tea to drink something without sugar (coke/cola needs to be classified as a restricted drug) it’s another pricey one, know not in comparison with some but again out of my range. 6 Reply The Honest Channel · 5 replies @toddh9507 @toddh9507 6 months ago I lift weights in the gym 5 days a week. I started taking NMN two weeks ago, 500mg a day. I've noticed that my lifts are going up in both weight and reps, and I'm taking less time in between sets because I have more energy and I recover faster. Is it the NMN? Probably, since I've changed nothing else. I've noticed my skin is looking better as well. I'm 54, 6'2, 185. I'm definitely going to keep taking this, why not? 7 Reply The Honest Channel · 1 reply @courtneybrown1698 @courtneybrown1698 9 months ago It’s interesting that she’s saying NMN requires less conversion than niacin but doesn’t comment on how NR (nicotinamide ribosode) compares to NMN. Most studies seem to claim that NR requires the least amount of conversion, making it the most efficient NAD booster. Tru Niagen (a competitor) describes NMN as not only inferior but almost identically to how she describes Niacin in comparison to NMN. 7 Reply The Honest Channel · 18 replies @seascape185 @seascape185 9 months ago Really interesting . Pretty sure I will start with one don’t want to shock my body at 65 and see how I feel before I add anything else . 3 Reply @cuidado555 @cuidado555 9 months ago Interesting information as usual 😉👏 1 The Honest Channel Reply @michellerosen6487 @michellerosen6487 9 months ago Took NMN for almost a year in conjunction with Resveratrol, no change in skin, or anything else. If that’s not enough, ALL of the NMN on the market comes from China and contains only minuscule amounts of actual NMN. There are only 2 places where it’s certified by independent lab. One is in UK the other is in Germany. I got mine from UK. Does nothing cosmetically or internally. So think really well before you shell out your money. It’s quite expensive. 9 Reply 6 replies @michelles2299 @michelles2299 9 months ago I think I will wait a bit first before diving in, it's expensive too, I believe that the US are no longer able to sell this as a supplement and are doing some trials or did I dream it? 😁 3 Reply The Honest Channel · 2 replies @callummarks2080 @callummarks2080 9 months ago Ordered a few bottles of NMN recently and am ordering more of "a better brand" and also ordering / trying out "Apigenin"... herd that supplements pretty good also! 😎💪👍 1 Reply 3 replies @nvb455 @nvb455 9 months ago I love that she does keto! Could you interview her again about fasting (autophagy) keto?? 7 Reply The Honest Channel · 4 replies @theguest6127 @theguest6127 9 months ago (edited) I'm afraid I have to disagree with her that there is any energy decline when you are twenty-eight. She claimed that she asked many people this, and no one has counteracted her statement, but there are two reasons for this. 1. The first reason is people are trying to be polite; if they sense that you expect a specific answer, they will go along with it. That is why there are better ways to gather information than street interviews because the participants won't tell you their truth only the truth you want to hear. 2. The further away you are from an age, the harder it is to remember the little details of how it felt to be that age. I mean I can't recall every specific emotions I felt when I was five. I am twenty-eight years old and haven't suffered a dip in energy. 2 Reply @AlM-he2gb @AlM-he2gb 9 months ago I am 72 already taking NMN.. I am a vegetarian.. I have lowered my carbs plus I do a eating window.. Very much like your show 9 The Honest Channel Reply The Honest Channel · 3 replies @wkgeneralwkgeneral527 @wkgeneralwkgeneral527 9 months ago I’ve read that NAD should not be taken by those who have had a history of cancer. As NMN is a precursor for NAD, would that hold true for NMN as well? 3 Reply The Honest Channel · 5 replies @chasingshangrila @chasingshangrila 5 months ago I have taken NMN for over 30 days along with TMG 1/1 ratio. I have felt no changes in energy. 2 Reply 4 replies @leth2753 @leth2753 9 months ago I take NAC (I'm in the US). Sounds like NMN is not available in the US unless shipped from the UK. 5 Reply 1 reply @ohfft @ohfft 7 months ago (edited) Why US authorities want it removed from the public's reach, proof they are not, or have ever been after people's best interests! 2 Reply @tanyts @tanyts 9 months ago I would love to know why not take directly NAD? Instead of NMN that has to transform in NAD in our body? 5 Reply 2 replies @russalochka87 @russalochka87 9 months ago Great interview! Can pregnant women, or women trying to conceive take NMN? 1 Reply The Honest Channel · 3 replies @charlessavoie2367 @charlessavoie2367 4 months ago Didn't the Food and Drug Administration reclassify it from a supplement to a drug, making it harder to get? What about selenium, taurine, carnosine, sulforaphane, jiaogulan?? 1 Reply The Honest Channel · 1 reply @akgh2010 @akgh2010 5 months ago OMG, I really love the way and style you talk. ❤ 2 The Honest Channel Reply The Honest Channel · 1 reply @Bigmdn29 @Bigmdn29 9 months ago Excellent information!! 2 The Honest Channel Reply @eightminusone @eightminusone 7 months ago I took it for a year, nothing to note regarding benefits but I didn’t do any research with blood work 1 Reply @pierrejeanes @pierrejeanes 5 months ago (edited) What would happen if someone take NMN, GLY NAC, Melatonin and AKG ?? 1 Reply @ronfulton2232 @ronfulton2232 9 months ago something that should be added the best way to take your mnm is to take it separately with luke or warm water and swish in your mouth for about 30 seconds 1 Reply @sharon240 @sharon240 9 months ago I always have a level of skepticism when someone comes on the channel with something to sell. I have to say it increased after she said she follows a keto diet. Are there any longevity doctors or experts out there who don’t have a product they’re trying to sell because I’d much rather hear from them. 36 Reply The Honest Channel · 6 replies @davidmanning1724 @davidmanning1724 5 months ago I have skepticism when I hear from the national institute of health 2 Reply @carloscarion1748 @carloscarion1748 8 months ago I fast, I eat one meal every 24 hours or use any Man I use R-alpha lipoic acid, Maca powder, moringa powder, and a few other aminos. I have had 20 rolls and teenagers say that I look younger than they do. It’s not my point to just look younger I like having the energy to continue doing what I do and really that is my whole case in point is to have the energy to do what I do until the time, if it exists, to leap the “mortal coil” 3 Reply @MrDancer1010 @MrDancer1010 2 months ago My doctor told me to take this for long haul Covid fatigue. Reply The Honest Channel · 1 reply @cosmospray @cosmospray 9 months ago (edited) How come with nr and nmn i feel sleepy all day long? I am a bit insomniac but i can go through my day generally but with nmn it’s impossible 2 Reply The Honest Channel · 4 replies @anjaxtv @anjaxtv 8 months ago Love her research on NMN but when I heard the carnivore diet thing it made me go Oh No! I think it's well established that in countries where a lot of vegetables, green teas, fish and CARBS are consumed are the countries where people live the longest. And look the youngest by eating a balanced diet and sun protection.. 2 Reply The Honest Channel · 2 replies @goodphone156 @goodphone156 9 months ago Good explanation. The Honest Channel Reply @Michael-gi5th @Michael-gi5th 9 months ago Isn't a lot of nmn testing done on rats? I'd believe it's benefits if there was more trials done on humans 2 Reply 1 reply @maryannsinopoli1751 @maryannsinopoli1751 9 months ago (edited) Wish magic for teeth regeneration. I dislike a dentist office. My uncle died in a dentist chair, so I am trying to refrain from such exposure. Face important but so are teeth. And the worse out there is metal in the teeth implants s as metal attracts fields from what I learned. 1 Reply @merlindxb4333 @merlindxb4333 9 months ago Clare, I got to tell you, I have on my workbench a Nitric Oxide generator. Will this do the same as NMN 2 Reply 2 replies @bertbrowm4488 @bertbrowm4488 9 months ago She looks really good for 35, looks youthful x 1 The Honest Channel Reply 2 replies @larsbars7875 @larsbars7875 9 months ago I was a follower of Dr Sinclair until I watched interviews with other researchers (Dr Charles Brenner, Prof Brian Kennedy, Dr Matt Kaeberlein). 5 Reply The Honest Channel · 2 replies @susandupre1457 @susandupre1457 9 months ago I’ve been on the carnivore diet since last May. I’m literally aging backwards. I wish I had started it sooner as I’m 60. I take an NMN supplement. Diet is an area where I highly disagree with Dr. Sinclair. 2 Reply 1 reply @ann6406 @ann6406 9 months ago Great video clare!! .i am understanding that if you have a history of camcer ..this supplement might not be a good idea ? 1 Reply The Honest Channel · 2 replies @Sweetp520 @Sweetp520 5 months ago You crave the carbs at the latter point of your cycle because it uses carbs to make hormones.Especially root vegetables they help your body produce progesterone. Will you ship your supplements to USA with ice packs ???? I ordered from another company D N A , and the powders temperature measured 100° and the plastic container was melted. Their guaranteed promise is to get it to your door undamaged .... I know nmn is heat sensitive , so I ask for my money back or for them to ship a new container with ice packs . They said their nmn was not heat sensitive , but that it should be stored in a cool place ....lol. Top Scientist David sinclair says it is . I offered to ship it back....They refused to refund refund . I will not buy from d.n.a. again , so I am looking for a new supplier. 2 Reply @larsnystrom6698 @larsnystrom6698 3 months ago Why do you imply that Dr Sinclair is the main figure when it comes to NAD+ and its precursors? I would give Dr Brenner at least some credit, since he did all the basic work. "Dr Brenner discovered eukaryotic nicotinamide riboside (NR) kinase and nucleosidase pathways to NAD. Brenner's work includes the first human trial of NR, which demonstrated safe oral availability as an NAD+ precursor" I don't consider putting an additional phospate group on NR such a big thing. The body still has to put one more phosphate group on it to get NAD+. And theres some doubt that NMN can get into the cells, without losing that pphospate group, and become NR. 1 Reply @pierrejeanes @pierrejeanes 5 months ago If FDA bans it you know it's good 4 ya 3 Reply @sansabh @sansabh 7 months ago I've been searching for the second interview, but couldn't find it Please post it again if you haven't already. Thanks Reply The Honest Channel · 2 replies @fongyeelam7465 @fongyeelam7465 9 months ago there are not a lot nmn experiments have been done human bodies. i just wonder has she had any experiment done on human and what is the number? 1 Reply @robertfleischer6068 @robertfleischer6068 9 months ago Taking NADH FOR 30yrs😊 3 Reply @laliyq290 @laliyq290 6 months ago Hi thanks for your video ❤ I living Montréal Canada 🇨🇦 This company is in uk ? They shipping to Canada? 2 Reply @wisdom.research1051 @wisdom.research1051 4 months ago Send me a direct link to your sales site please Reply @lgroves336 @lgroves336 9 months ago Much more expensive in the UK 1 Reply @paulsmith8412 @paulsmith8412 8 months ago The price she charges for nmn is almost criminal Don't go to nmnbio Just can't believe it I take one a day 500mg and it's 8p !! I kinda got the feel her prices would be ripoff😢 4 Reply The Honest Channel · 1 reply @maryanntorres3347 @maryanntorres3347 9 months ago I am so upset that the FDA is pulling the product. Leave it to the USA. So many positive benefits . Reply @j2shoes288 @j2shoes288 9 months ago Didn't hear her talk about the effects on her parents? Reply The Honest Channel · 1 reply @mattiuzzididier8911 @mattiuzzididier8911 7 months ago Hello. Why are you selling only in us. I't really frustrating 😢 Reply @davideluciano7761 @davideluciano7761 9 months ago I'm trying it from black forest company first bottle 2 Reply @sterlgirlceline @sterlgirlceline 9 months ago ⭐️⭐️⭐️⭐️⭐️⭐️ The Honest Channel Reply @tedschwartz2142 @tedschwartz2142 9 months ago ACCORDING TO WIKIPEDIA THERE IS NO PROOVEN EVIDENCE THAT NMN WORKS .. 1 Reply @ryananastasiaquinn5543 @ryananastasiaquinn5543 9 months ago (edited) KEEP your eyes on this one .... she seeems ... promising ... 3 Reply @jewellusher3636 @jewellusher3636 6 months ago Well at 68 I guess I'm done 😢 Reply The Honest Channel · 1 reply @ascenjoe @ascenjoe 9 months ago Do you know how people with Parkinson’s disease does with this? Reply The Honest Channel · 3 replies @hildacalderon1683 @hildacalderon1683 9 months ago E leído q puede dar cancer Reply @furiousdoe7779 @furiousdoe7779 9 months ago Females and the skin obsession …. hilarious. 😂 1 Reply @babyUFO. @babyUFO. 6 months ago 1:51 Completely false. There's Dozens of American companies within the US selling direct to consumers. Amazon is the only place that stopped selling it. 2 Reply The Honest Channel · 2 replies @jaykent1836 @jaykent1836 4 months ago STOP taking "expensive NMN", and take NIACIN! NMN is broken down, in part, to niacin, within the gut, so all you really need is the niacin...sheesh! Slick marketing hype! 2 Reply @user-md2et1yr3v @user-md2et1yr3v 5 months ago Hi miss give me ideas how can I get in Nepal 1 Reply @maryphillips9837 @maryphillips9837 9 months ago How can I order. & how can I know if Nmn. Right. For me 1 Reply The Honest Channel · 1 reply @thomasnieborowski562 @thomasnieborowski562 9 months ago 500 grams -> 500 milligrams Reply @TheBiffsterLife @TheBiffsterLife 7 months ago NR works better Reply @toomanymarys7355 @toomanymarys7355 9 months ago You should go back on tretinoin. Read the studies. You were BSd by people selling things that don't work as well. Reply The Honest Channel · 2 replies @lq4657 @lq4657 5 months ago Are you still pro vaccine? 1 Reply @Joejoe-dk7ri @Joejoe-dk7ri 7 months ago Another money trap.. 4 of us used for 7 months. None of us got any benefits from supplement. We were thinking why not try directly NAD supplement rather then nmn ? I took NMN for 6 Months | Here's What Happened JT Jared Taylor 25.1K subscribers Subscribe 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 K Share Clip Save 49,227 views Mar 18, 2023 To try NMN from DoNotAge go here: https://donotage.org/product/pure-nmn/ Use the coupon code "KETOWITHJT" to SAVE 10% If you're interested in NMN from ProHealth Longevity go here: https://www.prohealth.com/ Use the coupon code "KETOWITHJT" to SAVE 10% I took NMN every day for 6 months. In this video we'll discuss my experience. Some topics include more energy, increased strength and looking younger. It's been interesting so far. I hope you find it informative. DoNotAge use coupon code "KETOWITHJT" to save 10% (can be used on multiple orders) (NMN powder) https://donotage.org/products/pure-nm... (NMN capsules) https://donotage.org/products/pure-nm... (Resveratrol powder) https://donotage.org/products/pure-re... (Resveratrol capsules) https://donotage.org/products/pure-re... (SIRT6Activator) https://donotage.org/product/sirt6-ac... (TMG) https://donotage.org/products/pure-tmg/ (Collagen) https://donotage.org/products/collagen/ (Hyaluronic Acid) https://donotage.org/product/pure-hya... Other videos you may enjoy: 🟢Does NMN Really Work? • Does NMN Really Work? | People Share ... 🟢Why you NEED to take TMG with NMN • Why you NEED to take TMG with NMN 🟢What is NMN? What does it do? • What is NMN? What does it do? A pill or powder are no substitute for a healthy diet, regular exercise and good sleeping habits. Once that foundation is in place I've found that supplements can be an added benefit. I hope you enjoy this video. Thanks! Jared Taylor "JT" NOTE: The above contains affiliate links. You get a discount and this channel receives a small commission for referring you. Thank you! Disclaimer. Yes, I am a certified keto and intermittent fasting coach. (Certified by Dr Berg). I am NOT a medical doctor. Information in this video or other videos on this channel are intended for informational purposes only and should never be considered medical advice. It is always best when considering supplements or making dietary changes to consult with your healthcare professional. Chapters View all Transcript Follow along using the transcript. Show transcript JT Jared Taylor 25.1K subscribers Videos About 180 Comments rongmaw lin Add a comment... @Pissarrio @Pissarrio 8 months ago thank you for your honest and simple to understand report on NMN and short to the point videos that does not take 2 hours to watch the whole thing like other channels that are literally 2 1/2 hours long and boring. 38 Reply JT Jared Taylor · 3 replies @chrisdiaz9701 @chrisdiaz9701 7 months ago Energy was definitely somethng I felt more of, but I think where I saw the most results were avoiding sickness. Everytime I felt like I was getting sick I'd take nmn and would feel great the next day, even my partner when she got sick we'd both take some and she got over it within 2 days while I never ended up getting sick. 8 Reply JT Jared Taylor · 1 reply @frankwilliams3036 @frankwilliams3036 1 month ago In terms of endurance, I've notice improvement since I've been taking NMN. I have a Peleton and it measures pretty much everything. I have been consistently able to increase my output per 30 minute exercise with a 302 output on 10/18/23. Compare that to a 259 output on 10/7/23. Then a247 output on 8/19/23 before I started taking NMN. My number have been consistently going up. Here is a 45 minute ride with a 434 output on 9/2/23 when I first started taking NMN. Compare that to a 377 output on 8/13/23 before I started taking NMN. I supplement pretty highly, but adding NMN has really made a difference, and I wouldn't have even check this out if it weren't for this video so thanks. And now, I'm going to subscribe! Just to remind you of who I am, I take the Lipsomal NMN Platinum with resveratrol and quercetin by CODEAGE. 2 Reply JT Jared Taylor · 2 replies @ren1018 @ren1018 8 months ago I have had similar results...the energy was the first thing i felt but it subsided quickly. NMN increased my strength and endurance the most. 16 Reply JT Jared Taylor · 4 replies @alaskawatchers8045 @alaskawatchers8045 8 months ago I take a basic multivitamin/mineral, NMN, TMG, Resveratrol and fish oil. It has been a few months and my energy levels are decent. I noticed after practicing karate, any scrapes or bruises I got seemed to heal much more quickly than before. 17 Reply JT Jared Taylor · 1 reply @larsnystrom6698 @larsnystrom6698 1 month ago I'm now at one month of 1 g a day of NMN. No change at all! But I have been taking a multivitamin/mineral for a decade. And it has high doses of all the B vitamins. 175 mg of NAM, for example. Perhaps one has to be deficient in vitamin B3 to notice any effect of NMN. I would have noticed any change in strength, energy, or recovery. My strength training has been the same for quite a number of years, and any small change would be easily noticable. My current view is that if you don’t have anything to fix, NMN won't do anything for you. By the way, I'm 75 now. 3 Reply 1 reply @morrislam1796 @morrislam1796 8 months ago Thank you for all the informative videos. I enjoyed my discount from donotage by using your discount code! I’ve been doing a 48 hours fast every other week for almost a year now. Would you advise people to take NMN while fasting or not? Many thanks! 5 Reply JT Jared Taylor · 1 reply @SuriaMohd @SuriaMohd 4 months ago I take 1g a day into 4 parts while doing Wellness fasting ( eating once a day ). It has helped make my skin tighter and firmer. Energy is amazing. Overall health is great 👍🏼 4 Reply JT Jared Taylor · 2 replies @Legitz @Legitz 6 months ago Cool stuff JT! I can't wait to here more about this as you continue to take it the coming months and years! 2 Reply JT Jared Taylor · 1 reply @manjunathamuddegowda @manjunathamuddegowda 2 months ago I've been taking NMN (1g) and trans-resveratrol (500mg) supplements for 6 months, and I've noticed increased hair loss. My hair is thinning, and my scalp is showing. Has anyone experienced this? Any advice? Reply @ericskinner7355 @ericskinner7355 5 months ago (edited) I have MS, hypothyroidism, tinnitus, now being tested for cushing's. My energy level is really bad, my doctors aren't very helpful and only want to have me on prescription meds. I would sell my soul for normal energy level. I'm also sceptical about supplements because of the vast amount of conflicting information. Thanks for the video. 5 Reply JT Jared Taylor · 3 replies @mscashwell @mscashwell 10 days ago I started with DNA also. I like the products as well as the affordability 1 Reply JT Jared Taylor · 1 reply @benjiebarker @benjiebarker 7 months ago You need to add resveratrol with NMN. Also eat once a day (intermittent fasting). You will definitely see a difference. 15 Reply 2 replies @brendacalderon9445 @brendacalderon9445 5 months ago Which one do you use? Brand? Capsule? Powdee? MG? How many times a day? I think that makes a difference too, knowing these questions. Thanks. I just ordered the GenF20 3 Reply JT Jared Taylor · 1 reply @j.5221 @j.5221 3 weeks ago Skin definitely looks improved, not dramatically but it's definitely apparent. 1 JT Jared Taylor Reply @debbiedebbie9473 @debbiedebbie9473 5 months ago Reportedly in a mouse research study, taking RESEVERITOL daily, did not help. Pulsing it, (taking every other day) helped the mice live twice as long. 3 Reply JT Jared Taylor · 1 reply @WOJAus @WOJAus 7 months ago 22 pull-ups in one go at 52?? Genuinely, really good stats! 17 Reply JT Jared Taylor · 5 replies @Lollsize @Lollsize 5 months ago i had a spider bite or insect bite on my nose. the skin in the area was red, inflamed, with a red blood vessel circle around it as if the body was putting this area into isolation. i also had 2 lumps on the side of my face . i would pick at these but they would never recover. if i squeezed the area on my nose , then liquid would come out the spots and blood , the skin would regrow back as angry and red. after nmn i still had the sore on my nose so i squeezed it again and again watery liquid would come out and it bleed as well . i noticed the next day that the skin was regrowing back but it was normal skin, not angry. the marks on my nose went. so i picked at the lump on the side of my face and they bleed but disappeared. skin was fine . really impressed. my bald patch on the top of my head, has thickened up as well . also had asthma so at the same time as taking nmn i also upped my vitamin d intake to 8000 iu and 200 k2 combined and i no longer have asthma. lungs are fine. 4 Reply JT Jared Taylor · 1 reply @mag4926 @mag4926 5 months ago Hi JT, i have an excellent sense of beauty and aesthetics and to be honest I find that not only do you look fresh and young but your overall personality is very energetic and positive. This is awesome and rare!🥳💫👍 2 JT Jared Taylor Reply JT Jared Taylor · 1 reply @JTheoryScience @JTheoryScience 2 months ago 1. What is your take on Dr David Sinclair and the controversy involving his NMN and Resveritrol companies and the NMN ban his company is lobbying for? 2. The Human NMN studies on NAD levels in muscles show no statistical significance, are you still hopeful on NMN or could you consider the placebo effect and your excitement over the hyped claims of NMN to be a factor? 3. I think the NMN hype has inspired people to act more healthy in general, for example: i just quit drinking alcohol after 5 months of taking NMN and resveritrol because i wanted to become more healthy so i cant say for sure if its just a side effect of my changed mental state rather then the NMN and resveritrol. 1 Reply @bjornbecker5574 @bjornbecker5574 1 month ago Thank you for your personal impressions. But you would have convinced me better if you would have measured your level of NAD+ before taking NMN and six month after taking NMN daily 😉. Why didn't you? 1 Reply JT Jared Taylor · 1 reply @noname-em9vo @noname-em9vo 2 months ago Thank you for sharing your experience. How much nmn do (or did) you take every day during that period? 1 Reply JT Jared Taylor · 2 replies @jenna6716 @jenna6716 4 months ago Id love to know metabolically how it is working. How is your BP, lipid levels, BMI. Ive heard amazing things about this and am visciously trying to stay off the hypertensive medications, with NMN+ Im wondering if this is possible. 4 Reply JT Jared Taylor · 3 replies @Kermit_T_Frog @Kermit_T_Frog 2 days ago I notice nothing. Between concerns for its effectiveness and concerns over all the reported fake NMN on the market,, I am very close to giving up on it. Pretty much every trustworthy authority out there agrees that if it has any benefits, it is minimal. And that if you are young and healthy, there's no need for it. 1 Reply @deezed6478 @deezed6478 7 months ago Would have been great if you shared a before and after photo! 2 Reply @vivianwang5980 @vivianwang5980 8 months ago Thanks for sharing your experience with NMN supplements. Ordered one year supply using your coupon code. 7 Reply JT Jared Taylor · 1 reply @snave59 @snave59 2 months ago I have been taking NMN for a few months.Have noticed zero effects.Neither good or bad. Reply @mickhans7516 @mickhans7516 1 month ago Would love testimonials from unbiased source not backed by own business and just pure 100% real testimonials, will try myself. 1 Reply @anderander5662 @anderander5662 7 months ago I got a very similar benefit from just taking niacin 500mg/ day....more energy and a sort of caffeine effect....also decrease in appetite. 1 Reply JT Jared Taylor · 1 reply @gobontu6224 @gobontu6224 2 weeks ago I'm waiting for someone to look for human guinea pigs for dietary supplements, then even people on a budget (like me) can benefit from food supplements. :) (I mean FOOD SUPPLEMENTS, NOT pharmaceuticals!!!) Reply @avyana8506 @avyana8506 8 months ago Hey. Do you take NMN, resveratrol, and tmg at the same time? How much resveratrol and tmg do you take? 3 Reply JT Jared Taylor · 3 replies @RONNIEYACOUV @RONNIEYACOUV 6 months ago You need to eat pomegranates if you want muscles tuned with pull-ups 3 Reply @MarryPopp @MarryPopp 5 months ago Thank You sooo sooo much 🙏💝💐🌈🌈👏🌈so NMN is also recomend for Sarcopenia muscle losting ?! 1 Reply JT Jared Taylor · 1 reply @lorismith2354 @lorismith2354 5 months ago I have to much energy, im in my sixties, i have no pain, i sleep like a baby, no diabeties, no wrinkles , my hair is thick, nice lenght, can i still take this. I take plant based iron, minerals. Lately ive been eating bad, im still healthy. My results on my test are good . 1 Reply JT Jared Taylor · 2 replies @barbararup2123 @barbararup2123 5 months ago Is Renue by science a good company to get NMN from? They have a dissolvable one Im thinking about. Thank you! 2 Reply JT Jared Taylor · 3 replies @taab7 @taab7 2 months ago 22 Pull-ups???? I'm calling bull-shite on that claim - unless you're doing multiple sets and 22 reps is the grand-total of all the sets combined. If you can do 22 pull-ups in one set then you would have lats like bat-wings. Prove it, dude. Shoot a video from one angle with no edits of you doing one max set of 22 full arm extension pull-ups. 1 Reply @UnansweredQuestionsA911t-ve2fg @UnansweredQuestionsA911t-ve2fg 3 months ago my feet were all dry and flaky and after taking this they are soft and smooth 2 Reply JT Jared Taylor · 1 reply @alexribeiro8805 @alexribeiro8805 5 months ago started it just because of the energy levels spike and one week on it and nothing happened to me, still sleepy as F.... during the day hahahaha 1 Reply JT Jared Taylor · 4 replies @alexknaus4511 @alexknaus4511 6 months ago Does timing to take it matter? I tend to take it in the morning 2 Reply JT Jared Taylor · 1 reply @debbiedebbie9473 @debbiedebbie9473 5 months ago I can't even do one pull-up. Lol 4 Reply JT Jared Taylor · 1 reply @ranghashalatr142 @ranghashalatr142 8 months ago But how can we get longevity madisine in Asia please reply me or not available in Asia Reply @superchargenurse @superchargenurse 6 months ago Has done naff all for me tbh 2 Reply @naleenichotoo3450 @naleenichotoo3450 2 months ago Does anyone feel tired when taking NMN and reseveritol? 1 Reply JT Jared Taylor · 1 reply @JSabh @JSabh 4 months ago NMN, ATP, Creatine and a decent herbal matrix with a healthy diet. That's what I do, and I workout often at 40. I'm in great shape and getting stronger. I'm 5 11, 180 lbs with a six pack and 17 inch arms. Just saying. 2 Reply JT Jared Taylor · 1 reply @michelledesouza1506 @michelledesouza1506 3 weeks ago Ive been seaeching which one to buy, and some come up as nicotinamide riboside. Is it the same? 1 Reply JT Jared Taylor · 1 reply @bokigitara1 @bokigitara1 8 months ago Hallo. thanks for video. Do you take NMN without another supstances? I think that you will get it nothing. TMG is one from more supstances what you must take it with NMN. Can you say what WE MUST TAKE IT together with NMN? Once more, you are very nice, but you must say the whole story.....Please? Reply JT Jared Taylor · 3 replies @martinsinclair177 @martinsinclair177 8 months ago I take it too but how can anyone not drink coffee? I get mine in China. $330/kilo 2 Reply @garrettjones3108 @garrettjones3108 4 months ago What mg's of NMN is everyone taking? 1 Reply JT Jared Taylor · 1 reply @lamloc5068 @lamloc5068 7 months ago only one question I have, what happen when you stop taking nmn after few months? 2 Reply JT Jared Taylor · 2 replies @gaston. @gaston. 3 months ago your skin issue sounds like psoriasis. I have it, goes along with asthma. Reply JT Jared Taylor · 1 reply @a.evansrn107 @a.evansrn107 6 months ago Why is prohealth so much more expensive than Do Not Age ? 1 Reply JT Jared Taylor · 1 reply @pierrejeanes @pierrejeanes 5 months ago How many joules of energy we are talking abouta Reply @aldelacruz5526 @aldelacruz5526 8 months ago I took this product and I felt nothing. 8 Reply JT Jared Taylor · 9 replies @joseandaya4506 @joseandaya4506 6 months ago Is it safe to take NMN if you have cancer, i saw of video of dr. Sunclair saying not to take nmn if you have a tumor 1 Reply JT Jared Taylor · 1 reply @germanicelt @germanicelt 8 months ago So what's 1 gram of NMN per day, from DoNotAge costing these days? 2 Reply JT Jared Taylor · 1 reply @MsHenryoh @MsHenryoh 2 months ago (edited) The placebo effect, you are getting healthy because you have been exercising and taking NMN. You are paying a ton of more money, and you want to get your money's worth in exercise! I did it for two years. I looked at Sinclair today he looks older .. he is not exercising .. keep up the good work I walk at least a mile a day and do a ton of exercises and feel great .. NO NMN. too costly! 1 Reply JT Jared Taylor · 3 replies @calizzaplz @calizzaplz 8 months ago Is anyone taking Wonderfeel Youngr NMN? 1 Reply @timbrown8170 @timbrown8170 4 months ago How much did you take daily? 1 Reply JT Jared Taylor · 1 reply @cord6733 @cord6733 2 months ago Can you stack this with Shilajit? 1 Reply JT Jared Taylor · 1 reply @GweneverElektra @GweneverElektra 6 months ago How much do you take? Thank you 😊 1 Reply JT Jared Taylor · 2 replies @RasikaGamage @RasikaGamage 6 months ago wts the dosage ur taking per day? 2 Reply JT Jared Taylor · 1 reply @sybo10 @sybo10 8 months ago what else are taking at the same time? collagen maybe? how old are you? 3 Reply JT Jared Taylor · 5 replies @anyssaadi1849 @anyssaadi1849 2 months ago It seems nobody has the answer but I'm going to ask the question anyway ;) ....since NMN has been banned from the planet, how it comes that some companies are selling them? To the one who gives me the answer, will receive some 1 Million dollars. Reply JT Jared Taylor · 3 replies @flyingosom202 @flyingosom202 1 month ago post a vid of your pull ups 😂 you're obviously a salesman putting out coupon codes for Donot age... so alot of this this bs. But especially that lol. No way you're getting 26 proper form full extension pull ups done my man 😂 come on now. Reply @ArkeOpen-kb2us @ArkeOpen-kb2us 7 months ago It's price is too much highe above 9 thousand Nepali ruppis its cant efford every Nepali 1 Reply 1 reply @whitedust696 @whitedust696 3 months ago Is this ok for diabetics 1 Reply JT Jared Taylor · 1 reply @selsoft @selsoft 7 months ago No, you look same. Reply @user-zg8yt6lu5q @user-zg8yt6lu5q 2 weeks ago How can oder adress plz how much cost? 1 Reply JT Jared Taylor · 1 reply @DM-jt4rh @DM-jt4rh 5 months ago How old are you bro? 1 Reply JT Jared Taylor · 1 reply @pierrejeanes @pierrejeanes 5 months ago Whaaaa haaapened Reply @alocin110 @alocin110 2 months ago You had a placebo effect not the supplement. Save some money for your retiring life. Critical Findings From 12 Key NMN “Anti-Aging” Studies Dr Brad Stanfield 211K subscribers Join Subscribe 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 . 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 K Share Thanks Clip Save 125K views 3 months ago 1 product I read all 12 NMN human studies to figure out if there are any proven benefits and whether we should use NMN supplements. 💊 My full supplement stack: https://drstanfield.com/pages/my-supp... … Dr Brad Stanfield tagged products below. Learn more MicroVitamin: A Low-Dose MultiVitamin & Mineral $49.00 Achieve your recommended daily intakes of vitamins & minerals without mega-dosing. Blended with Hyaluronic Acid for glowing skin, and TMG for exercise performance. With over 75% of Americans taking dietary supplements, multivitamins have become a staple in our daily routines. But have you ever stopped to question whether your multivitamin is truly giving your body what it needs? 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SHOP Dr Brad Stanfield 1,145 Comments rongmaw lin Add a comment... @DrBradStanfield Pinned by Dr Brad Stanfield @DrBradStanfield 3 months ago Really unexpected finding in that last study 💊 MicroVitamin (multivitamin & mineral that I take): https://drstanfield.com/products/microvitamin 💪 Join Patreon for early access to my videos & Discord chat: https://www.patreon.com/bradstanfieldmd 💊 My full supplement stack: https://drstanfield.com/my-supplements 27 Reply 22 replies @carma23 @carma23 3 months ago (edited) Thank you for your breakdown of the reports. I’m 44, female.I have chronic fatigue and have tried a multitude of different supplements, some helped slightly only. Then I tried NMN 2 months ago and my life have improved immensely. I now have the energy/power to exercise and for my daily duties which I didn’t have before. I had to force myself hardly to exercise, and I was also without energy after. My lifestyle was healthy as it is now. With NMN I have constant energy through out the day. My mood has lifted greatly and my brain fog disappeared. I am so very grateful to have found NMN, I was really scared as I was not getting better from my fatigue previously, no matter what health improvements I made. I find these results you’re speaking of very strange and there are a lot of peculiar things happening around NMN, like the FDA ban. Strange things happening behind the scenes here. 💰 107 Reply 22 replies @noozachem @noozachem 2 months ago Hi, Brad thanks for the review. I've looked up all of the 12 studies and 11 of them mention oral supplementation. Not liposomal capsules or sublingual powder. I think it is important to point it out, as we know that NMN is a fragile molecule that breaks down in our digestive system, so these findings are of very limited use. 27 Reply 3 replies @samsharp3579 @samsharp3579 3 months ago As a 53 year old cancer survivor (prostate surgery, and follow up radiation therapy) I found NMN to be helpful. I've been on it (500mg a day from Renue by Science) since Dec 2022. My opinion is that it is essentially just a vitamin, and acts very much in the background. In fact, it is a type of niacin (vitamin B3). You can also take nicotinamide, for perhaps a better effect. The immediate effects I felt was a decrease in muscle and joint stiffness and soreness. A decrease in inflammation. Though, perhaps it was working in tandem with other supplements I take. Hard to say. I would say that it helped my energy levels enough, that I started running again three months ago. 143 Reply 22 replies @brttchrltn @brttchrltn 3 months ago I appreciate the video but it doesn't seem to address the 'anti-aging' question as mentioned in the title. I don't take NMN as a sports supplement, I am only interested in it's potential effect of helping to repair DNA. Are there any studies which answer this question? Thanks! 137 Reply 22 replies @michaelfishman1714 @michaelfishman1714 3 months ago Dr. Stanfield - Here's an account of my personal experience when starting NMN supplementation. I learned of NMN in 2019. I was interested in its supposed DNA benefits. At the time, I was in my late 40s and actively training in Brazilian Jiu Jitsu. In Jiu Jitsu class, we always spent the last 30-45 minutes sparing, or "rolling" as we called it. This was very intense physical activity, especially so given my age. Each round was 5 minutes, with a 1 minute rest between rounds. At my peek physically condition in those days, I was able to do two 5 minute rounds in a row (or on rare occasions three), and then I typically had to rest a full round before I'd have one more round in me. After that I'd be done for the day. When I started taking NMN, I found I was immediately able to do 5-6 rounds in a row. At the time, I was unaware of the supposed cardiovascular benefits of NMN supplementation, so I'm disinclined to think it was simply placebo effect. Adding on to that is the unlikelihood of placebo effect resulting in a sudden doubling exercise ability. Is that an incorrect assumption? That said, if it wasn't the NMN, what could it have been besides placebo effect? I wondered if maybe the NMN brand I was using contained an additive like caffeine, but I can't say for sure. I don't think so because I know I'm very sensitive to stimulants as they greatly disrupt my sleep. I've never had any sleep disruptions from taking NMN (or products labeled NMN). 37 Reply 7 replies @jad1175 @jad1175 1 month ago (edited) I have been on MNM 1000mg, resveratrol 1000mg and Berberine since 7/19 Since then my blood tests are perfect, my blood pressure is 110/70 I’m 70 my grey hair and grey beard has turned to salt and pepper, my A1C is 5.1% down from 6.4% pre-diabetic. I have a feeling of wellness since I started. My weight is 160lbs down from 210lbs. That’s all I can contribute to this video. 7 Reply 1 reply @G.G.8GG @G.G.8GG 2 months ago Always good to have contrasting opinions to keep us aware. I have noticed though, that Dr. Stanfield specializes in telling us about things that don't work, even when a significant number of folks have had success with it. I have seen reports that show that NMN has worked or has potential. As always, we should each get the best info we can, including pro & con and especially safety considerations and make individual decisions for ourselves, along with the docs. Personally, if I hear testimonials from a large number of people who have had success, that carries weight for me. 4 Reply @HD-no4dz @HD-no4dz 3 months ago I've been taking NR for several years. First week of taking it, I had heart palpitations. After the first week, everything settled and didn't notice much difference except slightly better endurance when exercising. After about a year however, looking back and comparing pre and post blood works. Wow, what a difference it has made. Lower cholesterol and much lower triglyceride. Started my mother on it, and again, after about a year, her blood sugar went from Type 2 diabetic levels to be within the normal range. Neither of us changed our lifestyle or diet when taking it. One set back though, NR did seem to agitate my liver quite a bit. 30 Reply 7 replies @catman4471 @catman4471 3 months ago I've been taking NMN for several years and have made no lifestyle changes but my results are amazing. Maybe these trials need to be more long term. 86 Reply 38 replies @whoami_888 @whoami_888 3 months ago You will see the difference when you are doing heavy exercises intermittently, say once a week or intervals more than that. Muscle recovery is far more improved when taking NMN based on my experience. Before taking NMN, it takes me 2 to 3 days before my muscle sores go away. But after taking it, my muscles are no longer sore after a heavy workout even after being sedentary for a while. 37 Reply 5 replies @gabymalembe @gabymalembe 3 months ago (edited) I’ve been taking NR for four years. I’m 80, and I feel great, but there’s no way to know if it’s because of the NR, since the science is still in it’s infancy. I figured if it eventually pans out, I’ll be glad, and if it doesn’t I’ll have wasted some money, so I chose to risk the money. So far I have seen precious little in the research about negative side effects. We know it extends healthspan in mice, but there aren’t any mice on either side of my family. 34 Reply 8 replies @Bshipbuilder @Bshipbuilder 3 months ago (edited) Brad, I take all my NMN powder sublingually. I started out mixing it with water and administering it sublingually with a dropper, because it was so expensive. Even though the price has gone down I now take scoops of powder and put it under my tongue. I'd really like to see some studies done with sublingual delivery because, wow, if it's a placebo what a placebo. 19 Reply 12 replies @augustmosco @augustmosco 3 months ago Thanks Brad, good video. I have to agree with your findings, I've been taking NMN (.5g-1g daily) consistently for the past 6 months and I've found no notable improvements in my health. I have always adhered to a very good diet and exercise regimen and am not very susceptible to any placebo effect. Thanks again. 12 Reply @pranayyou1 @pranayyou1 3 months ago Sorry, I couldn't watch the entire video, but here is my experience, I am 37 have been taking NMN for last 2 years and I workout as much as a 20 years old guy in my gym I lost this stamina about 2 years ago and thought I couldn't compete with them ever again, I accepted that I was growing old not any more. But my twin brother who isn't on NMN is experiencing a lot of issues, forget about working out, he can't walk much he has to take a lot of rest in the bed and that is a very bad sign. But we can contribute it to our eating habits and lifestyle choices since we were 20. Coming to my Mom, she is 60+, she has always been a very active person, but since 2021 she was not able to do household works she would start cleaning and then would sit take rest and complete the work later on, she wouldn't be able to stay standing up to cook the food and was getting very frustrated, I was more frustrated that she was not taking rest and was yelling at people due to the fact that she can't work as much. Then came corona people started to die left, right, center in India, so many died in my own locality, I was not going to give NMN to my mother but was afraid that I would lose her. No clinical trials were done on humans that I was aware of, I gave her 500 mg A day and she was working as she used to, she never felt tired again. She started to sleep like a baby. She has been active like she was 20 years ago. She is outworking everyone except me in my family, so I don't know about these studies but this stuff works and if you are on it (now it is cheaper then before), continue taking it guys. 17 Reply 2 replies @thepatternforms859 @thepatternforms859 3 months ago (edited) I use NMN for recovery in endurance sports. I’m an iron man triathlete and train 13-19 hours a week and sublingual NMN makes a MASSIVE difference in performance and recovery feels like a 100% boost. Would not want to train without it. Anti aging is irrelevant to me and these studies looked at vo2 max and max strength. Again, irrelevant, the only drugs to boost these are anabolic steroids. NMN boosts RECOVERY AND RECOVERY IS MASSIVE IN SPORTS TRAINING…. Also muscle NAD is boosted with sublingual rout and IV not oral. Something the study didn’t look at… increased insulin sensitivity at the muscle may play a very important role in both recovery and endurance. 25 Reply 10 replies @beauschmidt1080 @beauschmidt1080 3 months ago I have taken many supplements throughout my life and I feel like NMN is one of the few that I can feel a difference when I take it. I feel like I can get another 15% of productivity out of my day. I know this is anecdotal, but I hear similar results from my friends. It works well for me so I’m going to continue to take it even though it is expensive. 36 Reply 4 replies @lordjim3109 @lordjim3109 3 months ago (edited) I`ve recently noticed a proliferation of anti-NMN findings coming from various corners. Like it`s being orchestrated. 11 Reply @ingramdw1 @ingramdw1 3 months ago This squares with my experience. I took 1g NMN for a year, and measured blood NAD levels before and after. I had a significant boost in blood NAD, which suggests my microbiome didn't munch all of it. I did feel great the first few weeks after starting, but that wore off, consistent with the placebo effect. I'm now repeating the experiment with NR. 41 Reply 6 replies @iggytse @iggytse 3 months ago I found NMN useful in removing age related fatigue. I also found adding B3 to a carb loaded Creatine had the same effect which shouldn’t be a surprise as NMN is a combination of B3, sugar and Phosphate. It is definitely doing something for me and has been life changing in that I now have the energy to train and the gym after working all day. 29 Reply @paths1111 @paths1111 3 months ago (edited) Would be curious to know if there's any difference in tissue NAD levels and efficacy (or lack thereof) with sublingual NMN, which should in principle avoid hepatic first-pass metabolism. Thanks for all the hard work scrubbing through the data! 1 Reply @friedux2065 @friedux2065 3 months ago Its important to buy enteric coated or liposomal NMN or NR. Because as you said most gets broken down before it can reach the small intenstine. Massive difference in effects between pure powder and enteric coated tablets for me. 4 Reply @Hannibal5812 @Hannibal5812 3 months ago On my specific case (I am suffering from Still disease - a kind of systemic polyarthrite), what I have been able to notice after having tried both NR and NMN is that with NMN I would tend to feel slightly more fatigue and have slight red flares on my hands, which is a sign of inflammation in my condition and in the contrary when I take NR, I feel a bit better, no flares, my skin seems slightly better and above all, I almost systematically remember my dreams when I wake up in the morning. I wanted to share my experience as I think in my case and with my conditions, effects of drugs and supplements are exacerbated and easier to see and feel and that I clearly noticed a benefit with NR and the opposite with NMN. 6 Reply @jdh0838 @jdh0838 3 months ago Appreciate the thorough detail, as always. Would love to see a similar study review of niacin supplementation to see how its results differ or are similar to NMN and NR. 4 Reply @Dvpainter @Dvpainter 3 months ago I'd definitely love to see larger studies and for much longer, like over a year or at least 6 months, but also with an equal amount of time viewing the levels of the people involved prior to see how it may effect anything that is going downhill in the people studied. I had heard somewhere about it not reaching far past just being in your blood prior, though. 4 Reply @MW-100 @MW-100 3 months ago When I started taking NMN, I changed nothing else. I was already exercising daily and eating well. I saw a big improvement in energy and mental focus after starting NMN. I don’t think this is due to a placebo effect since I have been taking it for more than three months. There is something to NMN and I will continue to take it (1000 mg once a day in the morning). I am a woman without existing health problems (and not over weight). Don’t know if that makes any difference. Regarding the studies cited in this video, I am wondering if how one takes NMN and with what other complementary supplements affects its effectiveness. I take it in the morning on an empty stomach and follow it up with TMG. 21 Reply 1 reply @Smiley_101 @Smiley_101 1 month ago Thank you so much Dr Brad for your honesty ! I too myself did a self study on me to see if NMN works or not through 1.5 yrs now and see how effective they are . I brought my NMN n almost all their vitamins at Do not age . Starting out I have seasonal allergies, does not work out so tmg , nmn , . Querchin in it and it does work for me till one day I run out of NMN n brought another company . My allergies was attacking me so bad everyday till really I go back to do not age comp . That why I become a believer in helping me with my allergies. But I do agreed with you it does not make a diff in our blood pressure , stop grey , cholesterol .. what I think it does it boost out energy level n help strength our immune system . Through the months of course it motivates me to buy more of their products . During the summer I decided to walks non stop everyday for at least 1.5 hrs to 2hrs after 14 years of slacking off here n there. What I do find out during my walks at the beginning it was hard on my breathing bc I suffer allergies anytime I’m exposed to stuffs Im allergic too for a good 4 days then it literally disappear . Ok one day I’m out of my nmn I would think my allergies coming back ?? After 2mos of walk ?? Did my energy goes down ? NOPE ! For 3 wks not taking nmn n restravtrol I do have some left but I decided to not take it see what happen .. all I see on days not taking nmn along w my other vitamins I have diarrhea anything I eat my tummy was refused to accepts any foods I eat :.. and that not how I want my digestive system to be depend on the nmn either . So I search online for probiotics foods and it been my miracles n saver than when I was on nmn . What trigger me about the nmn that it may not be as good as it hyped … it my final test 😅 I decided to send an email to do not age see where they stand with the nmn n restrvatrol 😅 I bet they didn’t know or have any idea . They thought I was being stupid complaining the product not being enough . You see in the most common sense if a products really that good as it claim . You would stand behind it and do anything to keep your customers and just send it out for replacement . Instead emailing them back being stupid and justifying it the right amount . 😂😂😂😂 that just telling me them idiots are money hungry and their products are not that great . 😅😅😅 .. I do give props to the nmn that it does boost my energy levels and help me combat my allergies but so can except use ..it does help w strength immune system but so can foods that probiotics . Cheaper too .. another word would I stop ? No adding on top of what works for me doesn’t hurts and maybe a little better but prob to another company n cheaper after I’m out . 1 Reply @rodrigoillas6085 @rodrigoillas6085 3 months ago Hi Brad, thank you for taking the time to read all those studies. Do you know of any studies with a different delivery method? Dr. Peter Attia also commented somewhere that he doesn't see how NMN would get into the cell when taken orally. Some people have said that sublingually might work, do you think that's a possibility? 1 Reply @bensandoval1383 @bensandoval1383 2 months ago I use NMN for less than a year with resveratrol and I feel strong and can careless of this report 2 Reply @SharonPitman @SharonPitman 3 months ago Thank you so much for all the work you do to help us understand the complexity of it all. It makes a difference. 1 Reply @dwintablet @dwintablet 3 months ago I take NMN daily and I tell people that it’s not a magic bullet. It makes me feel like I have energy and want to exercise. I worked out most of my life and started to lose that motivation and high I get from exercise. NMN allowed me to have that high feeling from exercising. I enjoy exercising now. Before NMN I’ve tried dieting and other supplements while still forcing myself to work out. I think now I have no issues So I do agree with Brad that NMN doesn’t have direct benefits but I think it give you a boost in motivation. All my friends also say the same thing. They feel younger and want to work out more. We are all in our 40s and have always exercised before. 11 Reply 3 replies @NutritionMadeSimple @NutritionMadeSimple 3 months ago excellent systematic overview. understanding what NOT to invest time/money on is just as important (if not more) as figuring out what does work 84 Dr Brad Stanfield Reply Dr Brad Stanfield · 21 replies @tominnorcal @tominnorcal 3 months ago Thank you for your study. I have been taking it about 3 years. For me it did two things within the first few months: My night vision came back (I’m 78) and my 10 year bout with gum disease stopped. My blood pressure also improved gradually over 2 years but that could be due to exercise. No help for skin wrinkles etc. why did I have some result while others did not? I don’t know but for me it worked at least somewhat. Perhaps the studies were so short. If it lengthens telomeres it may take a long time as cells reproduce. Prior to NMN I took NR for about 2 years with no result. 8 Reply 5 replies @switzerland @switzerland 3 months ago Interesting, but I thought NMM mostly should affect aging. Which again is less of an issue on younger people, therefore won't help younger people. NMN levels are more likely lower in older people. I would like to see a study with different age groups and less on sports. 3 Reply @MissesWitch @MissesWitch 3 months ago I think more studies should be done, like effects on energy levels, skin/hair and nail health. 7 Reply @martov4330 @martov4330 2 months ago Taking 1-2 grams of NMN daily for 1-2 months fixed my sleep schedule and quality 2 Reply @deanz9161 @deanz9161 3 months ago NMN has been a game changer for me. Y’all can take what you want, I don’t really care. But If you are over 55 you may want to consider it. Don’t take my word for it, get your NAD levels tested before and after. 19 Reply 3 replies @walkerdale6602 @walkerdale6602 3 months ago My personal experience NMN has been life changing. For the positive of course 2 Reply 1 reply @keng7758 @keng7758 3 months ago This is huge in my view. I’ve been questioning the value of NMN for months as I’ve been on it ( from DoNotAge) for 20 months. I’m a 68 yr old male in good health and have experienced zero impacts from NMN in workout, energy, cognition, etc. Many of the YouTube influencers rely on their personal workout experiences to validate the value of NMN and I’ve been increasingly suspect of these anecdotal, placebo prone reviews. While I like what Berberine has done for my blood glucose and A1c levels , along with my lipid levels…I’m not planning to buy any more NMN from DNA or other reputable suppliers. I’m also a big fan of Creatine but NMN seems like a waste of $ and I’m ending my use of it. 35 Reply 16 replies @landoishisname @landoishisname 3 months ago I'm interested to see how NMN will work for CVD and potentially for weight loss, I feel like the only time NMN will improve aging is if your "aging" metric is how much NAD+ is circulating in the blood Reply @lukeotoole9554 @lukeotoole9554 3 months ago How sad is it when i feel the need to applaud this man for unbiased content! Great stuff. Any plans to do an anti- aging theory of everything? 13 Reply 1 reply @helgaotto7801 @helgaotto7801 3 months ago There's definitely something strange going on because I developed incredible amounts of energy when I started NMN, too. I literally started walking & running 3-6 hours a day, often with a heavy backpack on, and then still had plenty of energy left at the end of the day. This is something I would've never even dreamed of being able to do. This energy lasted for about a month. I don't feel the superhuman energy anymore, but I'm 100% sure it wasn't placebo as the effects were too extreme, lasted too long and as I had tried almost 100 other types supplements, none of which gave me effects that even came close to NMN. Reply 1 reply @mysteriouse5891 @mysteriouse5891 3 months ago (edited) I haven’t changed my diet or taken a high dose. But what is making my hair color change? I would say 80% of the gray/white is now brown. Started to notice after almost 3 months of 500 mg per day powder 6 Reply @NathanielStickley @NathanielStickley 2 months ago I tried it; after about 2 weeks of the recommended dose, my eyes started itching very badly (the insides of my eyelids). The itching went away when I stopped the NMN. Taking half of the recommended dose didn't cause itching, but there were also no other noticeable effects. Reply @papapiers1588 @papapiers1588 3 months ago I taken NMN. My position is that all supplements should be up for personal review. I am delighted to hear about these critical findings and will build that into my decision as I progress. Thanks. Reply @Asiatranceboy @Asiatranceboy 3 months ago Thanks for helping to burst my bubble 😂 Much needed and valued objective critical review of the scientific evidence. Thank you. 🙏🏻 Reply @Disasterina @Disasterina 3 months ago Great video Brad! I love how thoroughly you researched it! Dr Brad Stanfield Reply @44heisman @44heisman 3 months ago I have found NR to be extremely helpful as an anti-inflammatory. 2 Reply @credo1658 @credo1658 3 months ago Awesome summary, thanks Brad. Creatine, taurine and omega-3s are my trinity 9 Dr Brad Stanfield Reply 2 replies @carvesnow @carvesnow 2 months ago I'm not a social influencer. I'm a life long physician athlete. I have been consuming a number of supplements for years. Nothing besides electrolytes and protein powders have had as profound an effect as NMN. So, somehow all the negative findings of the studies are exactly what I have experienced as positive findings(except for muscle levels I have not tested). I consume 250-400mg per day. How is it that the 50 year old plus athletes I associate with are experiencing the positive results that I am. We are not new to the supplement scene and have taken many a claim with little expectation. NMN has been different. 2 Reply @russeldeakin8792 @russeldeakin8792 3 months ago Higher nad in the blood seems like a good thing to me. You really did a disservice to the topic by emitting the amount of nmn and the delivery method being used in the studies and by youtube influencers. I took nmn and feel like it had profound effects but not consistent. that tells me we have more to learn about how it is best taken in and used by our bodys. 2 Reply @garicklim4931 @garicklim4931 3 months ago I am 48 and was having meniscus injury at my knee joint. I had been suffering pain for years , not even any medication can cure my problem. After taking NMN for 3 months, my pain gradually go away , and now i can start back my jogging from 1k intially to alomost 10k training per session. Hence, i really doubts of your findings here honestly. 2 Reply @MOVIEKICKS @MOVIEKICKS 3 months ago Dr Stanfield, your findings match my experience taking NR which I understand is supposed to act similar to NMN. I notice no difference in energy, strength, nor anything else so I stopped taking it after a couple months. Reply @carlr2837 @carlr2837 3 months ago I tried Nicotinamide a few years ago, and felt like it did nothing for me, but I know a couple of older guys who felt like it was beneficial for them. One was 75, and the other was 86. Maybe NR and NMN are beneficial, but only if you are 75+, and your natural levels have significantly declined? Are there any studies where they limit the participants to 75+? Reply @omvilla7469 @omvilla7469 3 months ago Useful... improved walking, muscle strength, endurance, hair, skin, maintained weight after losing some (already slim), better eyesight, no need for reading glasses, unending energy, easy recovery, less hangovers... Lol... and personally I don't think it's a placebo effect, cause I didn't know much when I started it, so I had no hopes or thoughts on the matter, things just started improving and 9 months on it they are still here... A lot of other things improved... btw... I think this is comparable with other thousands of people... On the other hand remember this: This doctor has a beef with Dr. Sinclair, so he will always say negative things about anything he promotes or discovers... And, you can always find tons of other studies showing other results, and then you only cited those... same way like any industry does... selective reporting...👋👋 4 Reply 1 reply @orion9k @orion9k 3 months ago I've bought NMN three times (10g 15g and 30g) with long periods in between, because I can't tell if it's placebo or if it works. I always go back to using Niacin Nicotinic Acid B3, it just feels way more powerful and beneficial (and it's 100x more cheaper). Reply @daved484 @daved484 2 months ago I take mine sublingually. Definitely have had improvements all around. There needs to be further in debts studies 1 Reply @maximedesjardins2967 @maximedesjardins2967 3 months ago (edited) First, thank you for that amazing review. It's quite important as we may have been hyped way too much. Is there a possibility that a sublingual protocol provides better results? Or that combining NMN and Resveratrol is important? Reply @Just4AZ1 @Just4AZ1 3 months ago I am prone to skin cancer. My dermatologist recommended nicotinamide with fernblock by Helio. I love to know your opinion of the product. Reply @broccool2300 @broccool2300 3 months ago I have been taking NMN for years. Not counting. I will be 57 this year and I can do more pushups than when I arrived at bootcamp when I was 18 years old and in the greatest shape of my life. I don't know man, something is working. 21 Reply 1 reply @GetMeThere1 @GetMeThere1 3 months ago Two questions: 1) I seem to recall a video from you awhile back which said that we simply cannot absorb NMN, and so it was utterly useless for us. Was that wrong? 2) What about the mouse studies? NAD plays a fundamental role in vertebrate metabolism (I'm quite sure). Among all things, one would think NAD metabolism would be conserved through mice and humans. Why such a difference? Could the original mouse studies have been wrong? 5 Reply 1 reply @adamloepker8057 @adamloepker8057 3 months ago I really wanted to see NMN prove itself, especially after all the hype. Thanks for being an honest critic of the research! It is well needed in our day and age.. 196 Dr Brad Stanfield Reply 18 replies @amberchike-udenze5089 @amberchike-udenze5089 3 months ago My husband and I took 1g NMN daily for about 6months and personally found no change. However, I’m 38, resistance train 4x week, and we are overall pretty healthy people. I bought into the hype and was let down. May try it again when we’re older. 1 Reply 1 reply @MyHomeExperiments @MyHomeExperiments 3 months ago From the comments I see that there is still something to NMN, which somehow these studies missed on. It seems like there are two factors on the effectiveness: delivery method and the pre-treatment NAD+ levels. It seems that it is most effective for people with low NAD+ (mostly old people), and when it is taken sublingually or in any other way that bypasses digestive system. Reply @iamgoddard @iamgoddard 3 months ago Great review. However, it's unclear how the endpoints you've listed relate to life-extension. The endpoints from the trials seem to be testing NMN as a potential sports supplement. Some guidance on why those endpoints tell us about NMN's potential to extend human lifespan would have been useful. Reply @user-qi4cf6he7n @user-qi4cf6he7n 3 months ago And now you see how pure businessman David Sinclair is. 1 Reply @bowser2005 @bowser2005 3 months ago A idea for your next video should be Niacin. Google scholar has studies showing Niacin has potential for treating NAFLD but other studies show it has hepatoxicity. 4 Reply @jimpiaz9537 @jimpiaz9537 3 months ago Hey Doctor Brad. I hope all is well. I've seen a lot of your videos. I think they're great. Thanks so much for doing this. If it's not too much trouble I'd like your opinion on my diet. A few facts about me. I'm 60 years old, and I'm trying to get into shape one more time in my life and stay that way. For the most part, I've always eaten one meal a day my whole life. Around the age of 50 I started to become hungry earlier in the day. I was 6ft in my youth, but now about 5,10.5ft. Old age and back surgerys, i guess. I was about 180 to 190 lbs my whole adult life. I've put on 20 to 30 lbs this last decade. I've run a lot in my life, and I have a resting heart rate of about 50 bpm. I stopped running around 50 years old because it started problems with my back. Also, consider that this diet really works for me. During the week for breakfast I eat 1 or 2 small hard boiled eggs. A block of chetter cheese about 1.5" x 1.5" x 2" < inches. A pice of hard Italian sausage about 3" long and 1.5" in diameter. 12 ounces of coffee heavy on the cream no sugar. For dinner I eat a 16 ounce Kachava. 4 Scoops half chi half chocolate. About 250 calories per scoop. I also have 1 or 2 , 0 calorie monsters and 1 or 2 bottles of smart water. On the weekends. An antipasta for lunch and any type of restaurant dinner for dinner. Sea food , Italian, or Mexican. Also I take a men's health one a day vitamin. I grew up poor and we eat macaroni 6 nights a week and on Sundays macaroni and meatballs. So I know it would bother other people but eating the same thing every day doesn't bother me. I hit 220 lbs to months ago when I started my diet. I weigh myself twice a day and it goes up and down but I'm trending down. In the morning post poop, I'm 208 to 212 lbs these days. My blood pressure is about 145/80 witch is a little higher lately. I do take medication for it. So, what do you think??? Thanks for your time. Your the best Doctor Br Nga mihi tuakana Reply @PiniiXever @PiniiXever 3 months ago (edited) What side effects do Finasteride and Minoxidil (hair loss medication) have on longevity and general health? Reply @catman4471 @catman4471 3 months ago Dr Brad, do you not think there might be something wrong with these clinical trials? Although I tried at first I haven't made any lifestyle changes. I had unstable angina when I started NMN but it stabilised soon after starting it. I've continued to take NMN for several yeras now and get more and more benefits from it. I have atherosclerosis and nmn is known to be good for the heart. Many people experience benefits from it, but this doesn't match the short term clinical trials. I have never in my life known my skin to feel so good as it does now, how cant that be if these trials are correct? My nose, my ears, feel completely different with my nose appearing narrower than before, and no I haven't lost weight. My benefits are so noticeable to others too. Surely these trials need to be looked into a bit deeper because I feel there is something wrong with the way they are conducted. Reply @SrNutritivo @SrNutritivo 3 months ago Thank you brad for your honest work. If you roast the main product of a company that provide you funding, that's a thing. Reply @Fearzero @Fearzero 3 months ago I've been taking it 3 years now. Never had the euphoria experienced by others but then again I have eaten a well balanced whole plant diet for 22 years and weight lifted the entire time several times weekly. I guess I will just bin my latest batch from donotage and wait for the rapamycin studies lol. 16 Reply @kristas-not @kristas-not 3 months ago i rather enjoy your channel, brad! you do some pretty solid presentation and research. out of curiosity, can we get a ”making of” episode? i want to see behind the curtain(s)! i want to see how you and your team: - you decide on a topic and research - write the script - prepare for a shoot - shoot - edit - post production - deal with the fallout thanks! --kaws Reply @IanRushtonMusic @IanRushtonMusic 3 months ago (edited) I must admit I'm quite relieved to learn NMN isn't all it's cracked up to be. The cost of supplementation collectively is not cheap and NMN in particular is quite an expensive option and for that reason alone I have not indulged, but rather focused more on supplements with well-established benefits. However, admittedly I did suffer a certain level of FOMO with regard to NMN and so it's good to now know I've not really been missing out on anything after all. Phew! 👌 22 Reply 10 replies @krage2005 @krage2005 1 month ago From my experience, with no chnage in diet, excersice regime, etc, I noticed that running long distances became easier from breathing point of view.. And this was one research done somewhere in Asia supporting this point which was not mentioned here. Reply @yairchertkow5199 @yairchertkow5199 3 months ago How does niacin and niacinamide compare to taking NR/NMN in these regards? You had previous videos saying niacin supplementation has benefit and it does included in your supplement stack. 2 Reply @versecannon3651 @versecannon3651 3 months ago I started taking NMN 250 mg about a week ago to treat my respiratory problems: phlegm buildup and constant coughing. I haven't coughed since I began. Reply @trentrobinson1 @trentrobinson1 3 months ago Hi Brad. Good work. Be aware that the company you promote in Do Not Age currently advertises its NMN as ‘Improving Strength and Stamina” as it main selling point. False advertising or misguided? 4 Reply 1 reply @jimroth7927 @jimroth7927 3 months ago For most of these trials you did not tell us the dosage. Why leave out this essential piece of information? 28 Reply 1 reply @lgroves336 @lgroves336 3 months ago Any studies on NMN AND TMG? This alone can make a huge difference in results. 8 Reply 1 reply @jakehayes1345 @jakehayes1345 3 months ago Thank you so much...I hate wasting my money!! That was well done... fair and balanced, great critical analysis.. 1 Reply @bloong1080 @bloong1080 3 months ago I love the critical examination, however, let's go with the one finding that you said about NMN in the blood definitely being raised by supplements, but not necessarily higher NMN in the muscles. It would seem logical to me that if NMN is higher in the blood than before, that somehow, in some way, that would manifest itself to some effect on the body. If the blood NMN is higher, does that mean that the muscle NMN (although not initially higher) replenishes itself faster than before? Also, what about NMN impacts on the brain, does having higher blood NMN help there in any way? If something like these effects occur due to higher blood NMN, then that's a real change on the body due to supplementation. Using your medical background, can you brainstorm any possibilities like this due to higher blood NMN levels? Just play the NMN optimist for a change to see what might be possible. Reply @berserker2012 @berserker2012 3 months ago I get the points you make here in this video, but I tell you I'm taking NMN since almost a year without changing lifestyles, diet and intermittent fasting: well, first days I could totally notice I took something new in terms of energy. If a discontinue the use for some days and then I reintroduce it, then I get again the same effect, so NMN definitely energizes me. I also regularly exercise and obviously I feel more energetic and willing to do more things. The thing is when you take it everyday then you get use to it and do not notice anymore. Thanks btw for the findings you shared which otherwise I should have go through myself one by one. But also all the people commenting before me and sharing our experiences to understand together how the hell this stuff works! Reply @commonsensefinancial4413 @commonsensefinancial4413 3 months ago Dr. Stanfield, I have not watched your entire video, but did notice a study on muscle strength? I have been consistently working out with weights in the gym for 40 years, I am now 59. I have been taking NMN for approximately 8 months. I have definitely noticed an increase in strength while lifting weights in the gym, nothing crazy, but no question, increased energy and strength while lifting weights. I personally think I know my body best and its limits when it comes to lifting weights. I feel some of these studies are not representative enough when performed. I think if you took 100 men that have been working out with weights consistently over 5 years, and are all over 50 years of age, you would get 100 men that know their bodies and limits when it involves weight lifting and strength. These are the people that can give you a more objective response to NMN increasing strength. I have no "Dog" in the fight for NMN, just my two cents. 2 Reply @JasonChurch1992 @JasonChurch1992 3 months ago Very unexpected after so much hype, but not surprised. I would love to know what you've found on NAD+ injections/IVs. Hope to see a video on your findings one of these days. Thank you! Reply 1 reply @Protolamna @Protolamna 3 months ago I think that the nmn in the brain give a bit more bit mental energy but it doesn't necessarily enhance mental performance. That's my experience as far as noticeable effects. Since all I wanted out of nmn was a mental boost I don't regret buying the supplement. 8 Reply 2 replies @MarkZiegler @MarkZiegler 2 months ago Over time, this can result in serious damage. "Prolonged strain on the kidneys can lead to kidney stress or damage, particularly in individuals with preexisting kidney conditions," Best says. While Best notes that creatine is generally considered safe when used as directed and most people can tolerate it without kidney issues, this is a good reminder that it's crucial to stick to guidelines when consuming it—or any other dietary supplement. Reply @victor00a @victor00a 2 months ago Thanks for the information. Do you have an opinion on the new trend with peptides for muscle recovery and growth? Reply @moc5541 @moc5541 3 months ago This video is the perfect antidote to "Reverse Aging: Dr David Sinclair on NMN & Anti Ageing supplements (including their side effects)" which appeared 8 days ago. 13 Reply 7 replies @llama6666 @llama6666 2 months ago 3/4 of the research papers quoted used 250mg or less per day for the subjects, taken in tablet or even powder form by swallowing and not sublingually. I know little about how blood NMN is supposed to be taken in by the muscles, but the one thing I'm sure is that Sinclair himself takes at least 500mg-1g per day. We need new research that involves higher dosages and different delivery formats! Reply @laughingoutloud3713 @laughingoutloud3713 2 weeks ago Wow i have never ever read so many positive experiences about a supplement like NMN Reply @sallyadams8220 @sallyadams8220 3 months ago Hi Brad thanks so much for doing this for us.....its so confusing out there. What makes it worse is when eminent people such as David Sinclair say they take these supplements and that they are helpful...same as resveratrol 4 Reply @haegisman @haegisman 3 months ago Thank you for this outstanding overview! Does this mean to you that you'll stop supplementing Niacin for yourself? Thanks in advance. Reply @Danboi. @Danboi. 3 months ago After stopping taking nmn and resveratrol after 2 years. It might be a coincidence, but i had weird nerve problems, I felt like I rapidly aged over the following year, instantly went gray, eyesight degradation, hypertension, muscle loss.. maybe it would've happened naturally, but i feel it happened suddenly 1 Reply 1 reply @samuelbrainsample @samuelbrainsample 3 months ago This video echoes my own n=1 experience: no significant changes when taking NR. I’ve not taken NMN directly, and since I’ve given NR several months of use, I don’t see a reason to try it. When my NR runs out, that will be it. Im also taking Mitopure (urolithin A) and can report nothing significant in terms of changes. It’s expensive as well so I expect big results. I’ll most likely be dumping it after my current supply runs out. So far, no magic pill. 2 Reply @stranger_unfamiliar @stranger_unfamiliar 3 months ago I started taking it shortly before the fda ban just because I didn’t want to ever fear missing out on it and I noticed 0 difference even at higher doses. Was very disappointed, various herbal adaptogens work worlds more noticeably Reply @miroslavhandzhiev8515 @miroslavhandzhiev8515 3 months ago (edited) I have tinnitus from antibiotic treatment and regular headaches from being an IT and staying on the pc all day which NMN helps with. Also don't sleep good because of a young child. I take about 600mg of nmn a day and it gives me a lot of energy. If I stop it for few days everything starts going back to normal(it is surviveable but not pleasant). Not seeing any anti-aging benefits - my beard continues going white :D but I feel better overall. 2 Reply @mbbrooks123 @mbbrooks123 3 months ago My experience from taking NMN is that, and I can say with 100% certainty, it is not a placebo effect. I don't buy into the hype of someone telling me about medications or supplements. What I know is I could barely function anymore and had no due to COPD, asthma, arthritis spine, hip, and neck problems. Now with combined NMN with my other medications, things are far better than they were. There are some other good things that I've been experiencing. Nothing has changed with my diet. NMN has also given me the ability to do a little home therapy. So, with those trials, I have no idea, and it almost seems unreal hearing about them. 5 Reply 4 replies @alexandraspring687 @alexandraspring687 3 months ago Hmm I think I will stick with my B vitamin and magnesium powder (which also has CoQ10 and taurine) ... it works very well in getting rid of my hypermobility-related fatigue with its plain old niacin etc., and its ingredients work together Reply @sandervandelden7698 @sandervandelden7698 3 months ago Great Review!! Thanks a lot for your work. Could you also make one on Nicotinamide riboside? Reply @mattygiggity @mattygiggity 3 months ago Disappointing results, but it would be good to know if you think there is still further interest. That being, method of ingestion, dosage and formulation. Can NMN consumed in other ways actually improve NAD+ in muscle, for example? Sub-lingual absorption as opposed to oral capsule? Reply @inuit97 @inuit97 3 months ago I do had a boost in performance after I have mixed NMN with TMG, and a big boost in excercise. Reply @helios4425 @helios4425 3 months ago The only difference I saw taking NMN was improved deep sleep according to my fitbit. As soon as I stopped, the deep sleep tanked Reply @lenthall4650 @lenthall4650 3 months ago Brilliant, unbiased, fact based content 👌🏻 51 Dr Brad Stanfield Reply @oscardelapena183 @oscardelapena183 2 months ago As a NMN consumer my self. He is cherry picking studies. I’m impressed by how hard he is trying to make NMN look useless. 2 Reply 1 reply @Gyreck @Gyreck 3 months ago - I've been taking Basis from Elysium Health for several years now which has had one very prominent effect that I'm curious about. For most of my life I've had serious skin drying issues during winter months, and every single year my hands dried out so bad that every knuckle cracked and bled regardless of what I put on them. After the first week of taking the supplement the texture of my skin noticeably changed and the dry/cracking during the winter has completely stopped. I didn't make any other changes at that time. Any thoughts on how this might have happened ? Reply @SlamminGraham @SlamminGraham 3 months ago Excellent summary. I fully agree. NAD+ precursors just don't work, at least with common pill-based methods. 1 Reply 1 reply @rafatlatif544 @rafatlatif544 3 months ago Still have 100 percent confidence on David Sinclair 1 Reply @doppelhelixes @doppelhelixes 2 months ago i use vitamin B3 instead and it works wonders against hangover! Tested it a lot! 1 Reply 1 reply @quepadrequemadreeducadores7237 @quepadrequemadreeducadores7237 3 months ago Weird. I am 40, worked out all my life. 1. Took NMN for 8 months and was a beast at the gym. 2. Stoped taking it for 2 months and i felt tired..gym activity went down...i felt old. 3. Took it again....after a while...the beast came back. I love it. I Will keep taking it. 51 Reply 17 replies @TraderCat.8763 @TraderCat.8763 3 months ago (edited) I can confirm what you are saying about NMN. I took it for long Covid issues like fatigue and loss of stamina and NMN hardly helped at all. It was a very expensive supplement that did very little for me. What did help was hyperbaric oxygen treatments (which was proven by research), prebiotics and probiotics as well as taking things that helped reduce microclots. I suspect that the supplement industry is filled with many fraudulent and questionable products. 1 Reply 4 replies @gppgle @gppgle 3 months ago I play a lot tennis - tennis elbow is my major pain point everyday, and then this NMN helps me relieve from this. I don't feel soreness anymore - even though I play the same every week like before. I take 500mg daily. Reply @friederichrex9622 @friederichrex9622 2 months ago What's even more surprising than these results is that this video has had 100,000 views, yet only has 26 likes! 1 Reply @elenac102 @elenac102 3 months ago I super appreciate your hard work, wow, 12 studies, I would have been a bit too lazy so I would have skimmed through them😅 Reply @lewynld @lewynld 3 months ago I would be very interested in your take on Urolithin A studies for mitochondrial health. Reply @MaybeTogether @MaybeTogether 3 months ago Thank you for your work! I trust your judgment more than most of the other longevity influencers 5 Reply 2 replies @tahoon2009 @tahoon2009 3 months ago one of the best videos about NMN, indeed it delivered the missing big picture over the studies Reply @funnyfyr @funnyfyr 3 months ago This video should be shared on SO many influencer feeds Reply @mac2658 @mac2658 3 months ago (edited) A few years back I started NR wich does the same as NMN and stopped after a few months, it made me feel wrong and threw away the remaining bottles. 1 Reply @Starship_X @Starship_X 3 months ago Nice analysis. Would be cool to see you interview Bryan Johnson - Blueprint, or at least go over his protocol including his diet, exercise, sleep and supplements, or maybe a video on each category. Need more rational doctors giving a breakdown of it. 26 Reply Dr Brad Stanfield · 5 replies @diamond_s 3 months ago Muscles are not the only organ. From what I recall NMN does raise levels of NAD in several organs but not in all organs. Also high 1g or more doses are needed. NMNH is said to be a superior version that raises NAD in more organs and to greater extent. 4 Reply 4 replies @pramuanchutham7355 @pramuanchutham7355 3 months ago Does the basic Niacin work better, in raising muscle NAD? And insulin-sensitivity? 3 Reply @mistermarkus5372 @mistermarkus5372 3 months ago It is essential to take NMN with Apigenin and TMG. 1 Reply @donwinston @donwinston 3 months ago (edited) Caffein is the only supplement that significantly helps me ride my bike faster. I've tried NMN, beta alanine, creatine, sodium bicarbonate, and various nitrate boosters. Unfortunately you can't use it much more than two or three times a week. Reply @AlexanderWhillas @AlexanderWhillas 3 months ago Usually, Brad gives you the sample sizes of these studies. The ones he did give were very small i.e. less than 20 per group. I follow him because of his rigger in assessing papers. But am i being biased because i want NMN to work? Will try stopping for a month and see if I notice an effect. 1 Reply @swites @swites 3 months ago Great summary and analysis. Thank you . Reply @MrRterra @MrRterra 3 months ago I wonder if it is not the case to check it if the subjects of the studies weren’t all in a mid range about the values of the parameters measured. I'm theorizing that perhaps the people who need it most will receive the most benefits. As my anecdotal example, when I gave my 78-year-old mother 300 mg of nmn daily, she and I immediately observed an amazing transformation in her energy levels. When I took it, aged 53, I also felt more energy, but not so unmistakably! So, for example, a person with triglycerides of 700 would have an improvement and one who already had 130 would not. 1 Reply @ericquinones1754 @ericquinones1754 3 months ago This is weird because I have been taking NMN for 1 year, and my gray hair has diminished. My recovery at the gym is way better. My testeroon went up 200 points, and I feel sharper. How is this a placebo effect? Why are they trying to make NMN a prescription drug if it didn't work?????????. 5 Reply @tyski9000 @tyski9000 3 months ago Just watched the resveratrol video from two years ago where you apologized for recommending it in the past, only at the end of the video to hear you say you are currently taking Niacin for NAD levels. Goes to show how much more on this topic there is to learn. Not a criticism by the way, it's easy to get misled by studies, I'm surely guilty of it as well and was also taking NMN, this video alone is saving me 10$ a month so it is very much appreciated. Reply @PankajDoharey @PankajDoharey 3 months ago Thanks Doc. Gresat that you went through 12 papers. Reply @jomon723 @jomon723 1 month ago Thanks for being honest and not selling something 👍🏻👍🏻 Reply @pedrofsantos @pedrofsantos 3 months ago (edited) Thank you! I have tried this for some time with absolutely no notable changes. Lots of money down the loo. Not sure why so many people insist that it has made a difference to their lives. Unless they have financial interests or an amazing placebo effect. Reply @wealthconglomerate @wealthconglomerate 3 months ago NMN has definitely worked for me and i know its not placebo 4 Reply 1 reply @jgarma @jgarma 3 months ago Excellent review! The evidence is overwhelming that the number one anti-aging pill is exercise. And the three types of exercise to focus on are cardio respiratory fitness, strength training, and mobility / stability training. Much thanks for taking the considerable time and attention required to produce this and all of your videos, Brad! 31 Dr Brad Stanfield Reply 13 replies @petertodorov1792 @petertodorov1792 3 months ago I love your work Dr Stanfield Thanks to you I am saving money by NOT buying Resveratrol, Gamma Vit E and Nad Reply @anotherviewofthings @anotherviewofthings 3 months ago Great analysis, thank you. I hear also the "unfortunate" echo of three most important things for longevity again: excercice, exercise and exercise. Plus enough sleep. Not again! Poor humans. I mean, exercise is fun, but ... Reply @Brian0wns @Brian0wns 2 months ago A study of top athletes would be interesting to tie it together Reply @hicoteo @hicoteo 3 months ago Thanks Brad! I would have been fine with the placebo effects. 😢 Reply @chrisjames923 @chrisjames923 2 months ago There is a recent YouTube video by Michael Chua MD titled: "Vitamin B3 is the New Holy Grail of Glaucoma treatment, Here's why." The suggested findings so far are that B3 is neuroprotective halting damage to retinal ganglion cells. Large clinical trials are ongoing. As an ophthalmologist, Dr. Chua is clearly excited by this. What struck me was the large doses used, 1000mg, 2,000mg and 3000mg. Way more than any diet could provide. I wondered what your thoughts are on long-term use of high-dose Vitamin B3. 1 Reply @jessicashaw5083 @jessicashaw5083 3 months ago Does this also pertain to niacin supplements? 6 Reply @bilguana11 @bilguana11 1 month ago Thanks, I almost ordered it. Note that Swanson has a BS surcharge on "free shipping". Reply @donaldhenderson1870 @donaldhenderson1870 3 months ago I took NMN for a year and wasted my money. It had no real effect but exercise a great deal. I've met a few dogmatic type who are true believers and have personal stories of wonderment. There are always these types. Reply @angryoldcanadian3905 @angryoldcanadian3905 3 months ago I've taken NR for about a year now and have felt no benefits from it. I feel that I have given it a fair test but this will be the last bottle I purchase. 2 Reply @tinahickson6352 @tinahickson6352 3 months ago I really appreciate your research. Thank you. Reply @annemuller4499 @annemuller4499 3 months ago I can confirm that NMN didn't change anything for me after 2 years. I just wonder about the very positive comments below NMN videos 🤔 maybe its because they changed their habits to positive while taking NMN. By the way there are more women who claim that they don't feel an improvement with NMN, men are much more positive. 🙏Hope that you won't get too much hate from believers in NMN. Thank you for your brave work and honesty. God bless you 🤗 Reply @deepquo @deepquo 3 months ago (edited) Can you do one on NR as well? Because it supports brain health. 3 Reply 2 replies @stevek5461 @stevek5461 3 months ago Great meta-analysis on NMN. Thanks for taking painstaking time on this question. I wonder how Dr. David Sinclair would react to your research? 1 Reply @Chaotic313 @Chaotic313 3 months ago Your content reflects a well researched independent voice always. Love it. Thank you Dr. Stanfield.❤ 3 Dr Brad Stanfield Reply @swimbait1 @swimbait1 3 months ago (edited) I’ve been taking NMN and resveratrol and have not felt any big changes. And I’ve noticed that even those who have taken NMN for years look about the same, no change. But, this is true for virtually every supplement I have taken over the last 40 years. I am still exercising and feel good but I was doing that before starting NMN. NMN appears safe and does provide some benefit so for now I plan on continuing to supplement with it while focusing on exercise and diet. Hoping a real longevity supplement will come along before I’m dead. 4 Reply 2 replies @AlexMedin @AlexMedin 2 months ago Have you actually taken NMN? I can testify for increased stamina, endurance and as matter of fact, I can’t take it in the evening because otherwise I wouldn’t be able to sleep. Reply @secretweapon7764 @secretweapon7764 3 months ago Why is muscle NAD level important vs. blood NAD levels? What is the mechanism to raise muscle NAD? And why doesn't something that increases blood NAD also increase muscle NAD? 4 Reply @MrJohnson57 @MrJohnson57 3 months ago Dr. Stanfield, since you mentioned creatine, I have a question. I had been taking 5g of creatine for more than a year until last week when I cut it back to 3g. My blood test showed an elevated creatine level and a low eGFR. I read that creatine can give false positives from these blood serum tests; yet, I have yet to hear from any YT influencer with medical or scientific backgrounds mention this. Why? Reply 1 reply @6magicman @6magicman 1 month ago Idk i have taken a lot of different supplements and have been disappointed but nmn seems to help fatigue and endurance.. Haven't noticed anything else though Reply @salusa_secundus @salusa_secundus 3 months ago I’m a 40yo very active male…after taking nmn, my sleep quality noticeably improved and my nails/hair grew faster. 6 mos later, I feel that it does not provide me the same effect it used to. 2 Reply 1 reply @gregoryphillips3969 @gregoryphillips3969 1 month ago No one supplement will give anyone everything they need. That being said NMN works in many different ways for the body especially when it comes to exercise performance, mood elevation and sleep quality. I am speaking from personal experience. It's always important to gauge the quality of the NMN one is utilizing. Without knowing it one can probably surmise that the host has a product of his own to sell. Like l mentioned there's no doubt that other supplements need to come into play but NMN is a definite value add. Reply @SilverFan21k @SilverFan21k 3 months ago Bro awesome video. ❤ 1 Dr Brad Stanfield Reply @livingsmart @livingsmart 3 months ago Considering that NMN turns mostly into Niacin in the gut, all these studies should ideally have an arm with slow release or non flushing niacin. 6 Reply 3 replies @michael-qp9xd @michael-qp9xd 3 months ago Hello Doctor- hearing much on Urolithin a. Is a formula of this called Mitopure by timeline. Is costly at about $1000 per yr. Several studies done and a few clinical type studies also. Can please review all details and do here a youtube summary on your thinking if any real benefits. Thanks so much. Great all your work here and appreciate very much. Michael 1 Reply @bodybyharry5493 @bodybyharry5493 3 months ago What about an NMN that utilizes liposomal technology to prevent degradation by the gut microbiome? Like the Lipo NMN by one manufacturer (name withheld so I'm not accused of promoting them)? I'd like to see this kind of NMN studied to see what kind of effects this might have on biomarkers. 2 Reply Dr Brad Stanfield · 1 reply @lookfeelbehealthy6320 @lookfeelbehealthy6320 3 months ago This is the major problem with studies that only measure improved blood levels. If the substance, in this case NAD+, doesn't get into the cells and tissues, it makes no difference, as simply having more of any substance in the blood means nothing. In fact, in some cases, such as increased calcium in the blood, is harmful. The best supplement to allow the body to make and increase its own NAD+ into the cells, among a bunch of other anti-aging benefits, is Urolithin A. 1 Reply @Zuluknob @Zuluknob 3 months ago @DrBradStanfield NMN seems too far downstream from the cause. Isn't it that senescent cells express cd38 and its the cd38 that causes the reduction in NAD+? So it should be better to reduce the number of senescent cells. Have any studies been done into NAD+ levels after taking a senolitic like fisetin or supplementation of taurine? 2 Reply @Hack3r91 @Hack3r91 3 months ago Really makes me wonder about the popular rat study...The rats which got NMN appeared to greatly outperform even the younger rats which did not in running, what may be going on with that? Surely the rats are not subject to the placebo effect! 1 Reply @eliuq4157 @eliuq4157 3 months ago I've taken nmn for 6monhs and felt that overall it may be a placebo effect, the rise in blood serum may be helpful in the brain energy department, but it doesn't do much for muscle or lungs, I find things like beta ecdysterone, rhodiola and epicatechin induce greater gain 3 Reply 6 replies @viracocha2021 @viracocha2021 3 months ago If we end up finding a supplement that helps DNA translation or the methylation pace I think we won't see any biomarkers improving as these processes could take decades. Wouldn't you agree? In the NMN case we don't see improvements in mouse longevity data nor human biomarkers so for now, I agree is better to focus on other things! Reply @jamesjones7138 @jamesjones7138 3 months ago What about taking NMN with some sort of bio-availability enhancer like Boron or Schisandrin b to drive uptake in to the muscles? Reply @johnb9942 @johnb9942 3 months ago I heard of a study that shows it improves kidney function. Have you seen that? 1 Reply @pi3ni0 @pi3ni0 3 months ago You are the hero we need ;) Good job! Reply @JonathanOvnat @JonathanOvnat 3 months ago Thanks for the video. What about NADH sublingual supplementation? Reply @jdholbrook33 @jdholbrook33 3 months ago Here's a study for you. I've been taking NMN for 11 months. 1g daily along with 1g TMG twice per day. I just turned 65. My results are profound. Eyesight, taste, hearing, sense of touch, sense of smell. All improved. Memory, cognition, ability to multi-task. All improved. I have never in my life been able to focus like I can now. Learning is easy. reading comprehension, very good. For the past few years, when I felt the urge to urinate. I had to drop everything and go NOW. Around 4 months into taking NMN I noticed that was much reduced. In fact I don't have that strong urge any longer. My ability to do tasks that I had been doing for years such as typing, running the machinery in my shop.. all things that were classified as "muscle memory". They had all become more difficult. I had to think about doing them or I would not do them correctly. Too many times I pressed the wrong button on a machine, simply due to my "muscle memory" being screwed up. No longer. I can type without looking and rapidly. I don't have to think about which buttons to press on my machines.. just like I used to do. One small thing that may not seem important but.. I can now put my pants on without holding on to something, just like I used to do but had not been able to over the past 2 to 3 years. Can I attribute all those "improvements" to NMN? Nothing else in my life changed. Same diet, same routine, same bed, same job so.. yes I can. What else? My skin is softer, the age spots on my hands are gone, my energy level is flat out amazing. I lost about 20 pounds without even trying. I feel like my testosterone level is going up. How do I know that? I wake up with a woody every morning. Been a few years (longer actually) since I had that problem. Anyway. there it is. My study. 68 Reply 21 replies @danadirck2109 @danadirck2109 3 months ago It’s probably well established at this point that NMN does not improve physical performance. However, the jury is still out to see if NAD boosters can increase longevity. Reply 1 reply @G.G.8GG @G.G.8GG 2 months ago One thing more: a doctor who says a patient was probably just affected by (insert phrase) makes me suspicious. They could be right, but i was gaslighted with that phrase many times before getting a true diagnosis of a congenital condition, a diagnosis which changed my life. Reply @ShelleySwyer @ShelleySwyer 3 months ago Wondering as a woman who is prone to and has to treat fibroids a third time if NmN could be making them grow? Reply @Frogman214 @Frogman214 3 months ago (edited) What was the duration and dose for these studies? Some people say they don't see results for three months and some taking up to one gram. Did they take TMG with the NMN, or am I being fooled there too? There's supposed to be this synergistic effect taking them together. Something about the donor methyl groups? 1 Reply @hoffmancapote @hoffmancapote 3 months ago Actually I would never take the advice solely from social media. I always look up the research on the American National Institute of Health. As I see it exercise is the best thing anyone can do to improve overall health and without a doubt the cheapest. This also depends how much you are willing to pay for your running shoes, bikes and weight training equipment but even these things can be modified for those on a low budget 1 Reply @omvilla7469 @omvilla7469 3 months ago Don't forget that he also needs to promote his Own vitamins for Longevity... just saying...🙄 4 Reply @daanretel4864 @daanretel4864 2 months ago How about MNM has a positive effect on neurotransmitters and is making people feel great? Also a bit easy to dismiss influencers. (Niacin has influence on serotonin I believe) Reply @akheeboss2726 @akheeboss2726 2 months ago Good analysis Dr. Stanfield. I am 79 years old and have been taking 500m NMN and 500m TMG for three years. I also exercised daily. At times I was very skeptical of your unenthusiastic cautous reviews of Dr. Sinclair's work. Now, I must apologize and commend you for your insight, tenacity and professionalism. 1 Reply 1 reply @ericroodhouse3994 @ericroodhouse3994 3 months ago As soon as I took NMN it abated my drowseyness from another medication amongst other things. I In my opionion none of these studies by themselves are large enough to prove anything either way. There are other studies that have said the opposite to what you report here but they were small as well. We need to see large scale studies in the thousands of people to draw conclusions. 10 to thirty people is not a good sample size. 1 Reply @101Aktuell @101Aktuell 3 months ago That is why I have been saying for a long time: whatever you swallow it will be destroyed by the liver and your digestive acid. We have it with Glutathione which is completely useless to swallow, with Melatonin and also with NMN. These are all unstable molecules that get easily destroyed and have a short half life. That's why I use patches and suppositories. They are also available now for NMN 300 mg. Let"s put it this way: if it is being suggested to eat a yoghurt before swallowing the NMN and the resveratrol, hoping that the yoghurt travels faster than the supplement and can do some magic in your gut til the supplement arrives...then I know, that this is bogus science. Then I know, something is completely wrong with the absorption. The little bit that arrives in your gut (because this is the place where most of it gets absorbed) will not do magic. Thanks Brad for the clarity and the hard work you have put into it. Reply @marilialevacov2939 @marilialevacov2939 3 months ago Brad has a personal dispute with David Sinclair, as we know, and I wonder if this has not influenced his efforts to disprove NMN and resveratrol. 😂 9 Reply 1 reply @Pluvo2for1 @Pluvo2for1 3 months ago Hey Brad, I see that Vince has just covered a sirt 6 study. Would you be able to look at that one too please? Reply @roybodien6927 @roybodien6927 3 months ago Great review! Thank you! Reply @MyHomeExperiments @MyHomeExperiments 3 months ago How is the current knowledge with taking CD38 inhibitors like apigenin and quercetin? Does it work? Reply @rgilbar @rgilbar 3 months ago I’d love to see similar treatment with statins based on latest. How does it affect hbA1c, muscle strength, etc. Reply Dr Brad Stanfield · 3 replies @rohrt1 @rohrt1 3 months ago If your takeaways are true for NMN then are they also True for NR? Reply @AlexEMF @AlexEMF 3 months ago However, Bryan Johnson said on his YT channel that he has experienced the benefits from NMN through his testing equipment. I don't know who to believe 🤷‍♂️ I remain neutral on this, but I don't think I'd supplement with it. We'll have to see. 6 Reply 1 reply @Philson @Philson 3 months ago Need more studies on the muscle nad 1 Reply @donaldhenderson1870 @donaldhenderson1870 3 months ago Thanks Brad. You one of the best healthspan YouTubers. Many YouTuber's don't understand or even read the studies and only repeat what they like emotionally. Reply @evh3811 @evh3811 3 months ago I thought mmm was for only anti aging. What he covered was athletic performance and insulin resistance etc Reply @mickmack9333 @mickmack9333 3 months ago (edited) maybe its the combined intake of NMN and Resveratrol works, as Sinclair claims..... also, it would b interesting to see if the mice of Sunclairs Lab had increased NAD Levels in muscle........ maybe its just enough to increase NAD Levels in the Thymus.....by the way, i took NMN and there is an effect i clearly noticed, which is, when i took more than 500mg, i haf problem to get to sleep Reply @Thesuperfractor @Thesuperfractor 3 months ago Maybe it depends, I feel like 10 yrs younger by only take it for two days 6 Reply 1 reply @AilsaPehi @AilsaPehi 3 months ago What were the time frames of the studies? Was it for the duration of the study or as suggested by the suppliers over a minimum of 3mths? 2 Reply 1 reply @Articulate99 @Articulate99 1 month ago Always interesting, thank you. Reply @cat-.- @cat-.- 3 months ago For all the comments that say "even though physical strength is not improved, NMN is still anti-aging", but if it is anti-aging, wouldn't you expect to see strength improvements? Reply @joheyo @joheyo 3 months ago (edited) I guess I can wait for the meta analysis then. Thanks Dr. Stanfield. Reply @Cathykirton @Cathykirton 3 months ago I took NMN. No changes and too expensive 😮 Reply @seektruth9982 @seektruth9982 3 months ago Instead of wasting your money on NMN, do the following: 1. Healthy quality Diet. 2. Regular Exercise and Resistance (Weight) Training. 3. Quality Sleep. 4, (Option): Take a quality Creatine Monohydrate. 3 Dr Brad Stanfield Reply 2 replies @theancientsancients1769 @theancientsancients1769 3 months ago New research is out with NMN Vs NR and NR seem to have a slight edge 2 Reply @jonnyoneplate @jonnyoneplate 3 months ago Would like to see your thoughts about HMB, Arachidonic acid 1 Reply @markfischer3626 @markfischer3626 3 months ago I have a lot of questions about these studies. Did the follow the salvage pathway? If they didn't, you can throw then out because they're worthless. NAD+ will get eaten up as fast as it is generated in addition to R-alpha lipoic acid and quercetin to generate NAMPT, TMG to add methylation, and apigenin and parsley flakes to block CD38, I'm adding EGCG to block the Methyl gobbling NNMT. I only learned about it today. To protect cells from high blood sugar and insulin levels use the vitamin B1 variant Benfotiamine. To increase muscle mass take Branch Chain Amino Acids, Leucine, Isoleucine, and Valine. This is necessary for the anabolism of muscle mass. A metabolic product is HMB but what little of it you make is lost in urine and isn't enough anyway, Take HMB supplements. It's an anti-catabolite for muscles meaning it slows muscle breakdown and speeds up recovery. I'm a 75 year old lazy bum and my muscles became huge and strong. Plenty of energy too. Strong fast gait, strong grip strength, fast standing up from sitting down. I've never felt stronger. Does NMN work? I don't know but if it can't hurt me and it doesn't cost a whole lot then why not. I take 250 mg a day and to boost its effect and that of other supplements I take it with 1000 mg of Leucine. Other Amino acids I take in the evening. I'm on a six hour a day eating window. I want to thank you for all of the information I've gotten from your postings. I share what I learn from others. There is so much to learn, so much new terminology. If you have any thoughts on any of my conclusions, I would appreciate them. 1 Reply @randomhominid9816 @randomhominid9816 3 months ago Social media hype and epic failure. NMN is a bust. There is no fountain of youth here. I'm glad I didn't waste any of my hard earned dollar on that one. Very well done analysis. I'm scratching this one off my list of hopefuls. Reply @KvasirBlut @KvasirBlut 3 months ago It seems its still relevant for skin cancer prevention in the other hand 1 Reply @joannaszczotka9443 @joannaszczotka9443 3 months ago How would you explain all the overwhelming effects of NMN in mice research? The mice also had a placebo effect and believed they were taking a longevity pill, that’s why they improved in almost every test? Reply 2 replies @Childofthebong @Childofthebong 3 months ago Ok but what about liposomal forms? Have those been evaluated yet? 2 Reply 1 reply @photo200 @photo200 3 months ago How many of these studies were across a matrix of dosages? My observation is that most of the youtubers out there with positive stories take far more than 300mg. That may or may not explain things but it seems like it should be part of any study. 3 Reply 1 reply @deanrobinson2459 @deanrobinson2459 3 months ago Brad, given some of the comments on this video, maybe you should do a placebo video and a confounding variable one too ! Reply @winningtechnique1849 @winningtechnique1849 3 months ago (edited) NMN - 250 mg twice a week. Insane muscle building effect, improved heart output, better recovery, no impact of no sleep at all on muscle mass. NMN is a must. I believe you could be looking for the wrong thing when looking at these studies. 1 Reply 2 replies @bestcomment3589 @bestcomment3589 3 months ago keep up good videos doc 1 Reply @stevenpersamanos23 @stevenpersamanos23 3 months ago What about AKG?? Do you need to pair Glycine with NAC to get its benefits? Reply @Primal391 @Primal391 2 months ago Any research yet on the benefits of injectable NAD? Reply @wendysmith2274 @wendysmith2274 3 months ago I have been taking it for 3 or 4 months I can tell you I feel amazing when taking 1000 mg a day I can easily run up a mountain Performance is excellent. And I am 72 …. 8 Reply 1 reply @teeztopz @teeztopz 3 months ago Can you please explain why we want NAD in the muscle and not in the blood? Is there no benefit to higher NAD in the blood? If so, what are the benefits of higher NAD in the blood only and what would be the downsides? A response to these would be greatly appreciated. Since this video seems to mostly focus on muscle NAD and you don't really explain the differences between muscle and blood NAD. Many thanks. 2 Reply 1 reply @lukaszporosa9847 @lukaszporosa9847 2 months ago How is NMN measured in the muscle tissue versus standard blood testing. Reply @TheYopeydopeY @TheYopeydopeY 3 months ago I wonder if liposomal nmn could increase muscle nad 🤔 Reply @hansnielsen6280 @hansnielsen6280 3 months ago Thanks for debunking the NMN/NR hype 👌🏻🐸 Reply @bobknob8261 @bobknob8261 2 months ago any test done on Liposomal NMN? Reply @nickgrossman2385 @nickgrossman2385 3 months ago I wonder if any of these studies used enteric-coated tablets to get the NMN past the stomach. I wonder if that may change the results. regardless this is very disappointing news haha. another exciting supplement is possibly useless. 3 Reply 1 reply @1Parkwa @1Parkwa 2 months ago Does this mean you're changing the supplements that you take? Are you still taking Nicotinic acid? Reply @carvesnow @carvesnow 2 months ago I don't know about these studies applying across age groups and level of fitness. My experience (physician athlete)has been very positive with NMN. Not new to consuming supplements or physical training. Have been training for 45 years. This NMN is a uneque experience. Have been taking it daily for four weeks (low dose 400mg/day)and things are different, better. Stiffness, aches and pain following, during workouts either completely gone or almost gone. No more stiffness following sitting for a few minutes (this started) almost a year ago. Minute ventilation is increased at rest(perhaps a carbohydrate metabolic affect; CO2 production/ventilation; tidal volume seems increased). Sleep and waking is much improved. Waking in the morning is easy now. Simply awaken and have the sharpness to immediately get going to the morning work out. The workout has been up hill interval sprints. Wieght training in the gym five to six days a week. As profoundly useful as a good electrolyte mix is at eliminating muscle cramping, NMN has been a game changer in daily energy level, sharpness and functional endurance. For me the top three supplements that result in an undeniable difference has been, Protein powders, electrolytes, and NMN. Sleep is always number one, then training, then quality diet and supplements. Good luck everyone. Hope you find what meets your own age related nutritional and supplement needs. Reply @joenisnapje712 @joenisnapje712 3 months ago Wow 😮 that is just as shocking as with the resveratrol. Reply @Resolutelt @Resolutelt 3 months ago Greg Doucette will cry after this video, as according to him, NMN is far better even than creatine. Respect to you Dr Brad Stanfield. Not everything in this world should be about making money. Reply @neilmcmanus3727 @neilmcmanus3727 3 months ago It would be beneficial if some billionaire would sponsor a clinical study for these same indicators, muscle strength, heart health, and arterial regeneration with individuals who were treated with umbilical cord derived mesenchymal stem cells (uMSCs) aka medicinal signaling cells, aka pericytes with regard to "anti-aging studies". Could you do a review report with regard to the beneficial effects, length of time within circulating blood, and dosage applications of umbilical cord derived mesenchymal stem cells as an application to kidney, liver, heart tissue healing and system healing within the anti-aging and translational rejuvenation medical practice ? Reply @MadDestructionChaos @MadDestructionChaos 3 months ago Why is the FDA trying ban it and plan to make it prescription only? 4 Reply 2 replies @manjunathamuddegowda @manjunathamuddegowda 2 months ago I've been taking NMN (1g) and trans-resveratrol (500mg) supplements for 6 months, and I've noticed increased hair loss. My hair is thinning, and my scalp is showing. Has anyone experienced this? Any advice? Reply 1 reply @unreactive @unreactive 3 months ago Excellent work! Dr Brad Stanfield Reply @johngibson7693 @johngibson7693 3 months ago What about liposomal NAD? Bypassing the gut Reply @JTheoryScience @JTheoryScience 2 months ago Dr David Sinclair mentions you have to take resveritrol with NMN to get any benafitss from NMN. What do you think? Reply @WhereNerdyisCool @WhereNerdyisCool 3 months ago Any thoughts or research you've found about Do Not Age's "SIRT6 Activator" ? Reply @davidperfette1425 @davidperfette1425 3 months ago (edited) The noticeable benefits I've experienced are in stamina and recovery. Those studies are not looking at recovery and little about stamina. I'm not a social media influencer. Nor do I follow any, so I'm not familiar with the hyperbole they're pushing. I've had good results in those two areas. I'm 56, I have been taking 1 gram of NMN sublingually for about five months, and I have experienced significant improvement in stamina during cardio activities, mostly running, and also in muscle recovery. The before and after difference is conspicuous. I am very in tune with my body. I exercise a lot for the majority of my adult life. In my twenties, I was a professional ballet dancer. I was hardcore 24/7. Now, I weight train and run regularly. Before taking NMN, I was constantly battling thigh and hamstring injuries (due to previous ballet injuries) which would lead to frequent periods in physical therapy. A hot spot on my thigh would always lead to PT, reduced or no activity, and a slow, monitored, methodical recovery, which happened regularly. That's how it was the five previous years. I was constantly in and out of PT. That's not the case any longer. Those hot spots that indicated or would lead to injury no longer do so. They last briefly and do not impede my running. Those acute hot spots no longer turn into injury and no longer linger. My increase in stamina enables me to run more miles, which would normally put me at greater risk of injury, but I haven't experienced an injury since starting NMN. The recovery from weight training workouts is not as easy to discern as many factors are involved, but I do push harder as I don't take as long of a recovery between workouts as I used to do because I assume that the recovery benefit I've experienced with running would be similar with weight training. The shorter periods in between workouts have not caused me any issues. I know my body well. My PTs know me well, and the difference is remarkable. These studies are not thorough. More research is needed. 11 Reply 8 replies @BR-hi6yt @BR-hi6yt 3 months ago What does it mean that NMN will boost blood NAD? 1 Reply @elensayista8988 @elensayista8988 3 months ago Niacin does work though, its even been specially good for my eyes as I stare at computers long hours. 1 Reply @naturelife418 @naturelife418 3 months ago Man you are the best, thank you Dr Brad Stanfield Reply @DUDIDUAN @DUDIDUAN 3 months ago I don't know about others, NR 100% helps sleep quality. 1 Reply @Am3gari @Am3gari 3 months ago I would like you to review about akkermansia, it looks semaglutide like Reply @jenxsj3902 @jenxsj3902 3 months ago I want to see what Sinclair will say about this…… 3 Reply 1 reply @ALDUIINN @ALDUIINN 3 months ago Excellent review Doctor, i'm greatfull for you to come with the Thruth above no matter what. That's something really rare this days. Everybody want's to sell you something. Thanks for the review, please, continue like that, and i wish all the best for you. Dr Brad Stanfield Reply @earx23 @earx23 2 months ago 2:25 "The NMN group was slightly healthier".. perhaps. They had lower triglycerides, but that was the only difference. Then the only thing that could possibly mean is that healthier people benefit more from NMN. It's to stay cautious seeing the group is small.. but this was also at very low dose NMN.. Only 250 mg/day. Reply @intuitivesean443 @intuitivesean443 3 months ago I wonder what studies on NAD Iv therapy would show? Reply @jacekpiterow900 @jacekpiterow900 3 months ago That was brutal. No hope. Thank you. Sometimes this way is better. 1 Reply 2 replies @oppothumbs1 @oppothumbs1 1 month ago Creatinine causes hair loss in some studies. 1 Reply @dingerma @dingerma 3 months ago Thanks for the truth. I stocked up before it went away on Amazon. I could have bought some bar bells. David Sinclair is going to have to find a new ‘snake oil’ to push. First Resveratrol, now NMN. 3 Reply 1 reply @borischan5252 @borischan5252 3 months ago are there any specific study with LIPOSOMAL version of NMN? if the issue is the NMN is processed by the liver too quickly... Reply @ElectricHorseman66 @ElectricHorseman66 3 months ago So the boost of energy i feel everyday, right after taking 700gr of NMN, is a placebo effect? Reply @gymjoedude @gymjoedude 3 months ago It's possible that it can reduce methyl groups which would be poor. Recommend betaine. Thoughts? Reply @JackB2646 @JackB2646 3 months ago How do you explain Dr Sinclair’s results? Maybe they are looking at the wrong markers. Reply @SilverFan21k @SilverFan21k 3 months ago Ty for the aging science updates 1 Reply @willbrink @willbrink 3 months ago (edited) Where's the comparative studies for good old cheap Niacin vs NR or NMN? I have never jumped on the NMN/NR hype train. I'm not convinced but regular exercise + niacin, plus co factors needed for NAD production, (Mg, etc) should maintain NAD+ levels. 4 Reply 1 reply @Edward-zw9ld @Edward-zw9ld 3 months ago ANALYSIS OF VARIANCE SHOULD BE APPLIED STATISTICALLY Reply @richardcabeza9596 @richardcabeza9596 3 months ago Supplementing with NMN without fixing the NAD Salvage Pathway probably limits the efficacy Reply @vanessalambert4286 @vanessalambert4286 2 months ago Could I get the NMN at Amazon? Reply @emergentform1188 @emergentform1188 3 months ago Brilliant, love it, you da man Dr. S! Reply @BethElliottArt @BethElliottArt 3 months ago What do you think about pentadecanoic acid? Reply @Residie @Residie 3 months ago (edited) ​ @DrBradStanfield do you think DONOTAGE should remove items such as NMN, NR, and Resveratrol now that you have shown that they don't work, before they start getting accused of being a snake oil sales company? 3 Reply @GH-cd6oq @GH-cd6oq 1 month ago The Powder form is better and you have to keep it in freezer. Sorry Doc Im a beleiver in this stuff since I have ran out recently can really feel the difference Reply @comeinhandynow @comeinhandynow 2 months ago Thanks, do those results also imply that NADH would have similar poor results? Anecdotally I feel like I have more energy on it, but not a scientific result. Reply 1 reply @rosaflorpuig3971 @rosaflorpuig3971 3 months ago What about Liposomal NMN? Reply @ybwang7124 @ybwang7124 3 months ago Hi Dr Stanfield could you do a review on Ozempic? that also seem to be highly hyped on social media 2 Reply 3 replies @chris-lk4ml @chris-lk4ml 3 months ago But what does it mean that it will boost blood NAD? Btw Im waiting for "But what about NMNthingi[number]? " Reply @emdude1784 @emdude1784 3 months ago I am an electrical engineer with a solid scientific back ground and is quite well versed reading and understanding scientific literature. I am very cynical about medical science literature , particularly those funded by special interests. Just remember the same type of papers support statins, propagate misinformation about LDL’s, the food pyramid etc and the list goes on. I’d say go with your personal experience when experimenting with a controversial supplement, especially if it does no harm. 11 Reply 1 reply @ronaldkoch2766 @ronaldkoch2766 3 months ago (edited) Everything I've heard is that NAD precursors are pretty useless in younger people, like under 35 because the body has all it needs, and that the greatest benefit will be seen in older people, such as the frail elderly people mentioned that for some reason was disregarded. I have also heard that it can take months and even years for NAD to make meaningful changes in the cells after so many years of neglect, atrophy and damage. Remember, the main reason for boosting NAD is to replace what has been lost with age, it is not a performance enhancing drug, and a study of a few weeks will not likely find any results. NAD is meant to repair DNA damage in the mitochondria, which does not happen overnight. Reply @advertiserfriendlyusername5362 @advertiserfriendlyusername5362 3 months ago Do you have any plans for making a revised or updated video guide on aerobic exercise? 1 Reply Dr Brad Stanfield · 2 replies @stephenpolwart2094 @stephenpolwart2094 3 months ago (edited) Interesting, I was just looking into this. By the way my mother was Dawn Stanfield Reply @shawnsnider7564 @shawnsnider7564 3 months ago I am only taking NMN to boost NAD levels, which is proposed to be helpful with anti-aging.. I am not sure the information here proves/disproves that boosting NMN levels is helpful in slowing down the aging process. Longer term studies would be helpful in determining if it is effective for that. Reply @baileystruss7319 @baileystruss7319 3 months ago One small study shows highly raised triglycerides with NMN supplements. Reply 1 reply @laydbac714 @laydbac714 3 months ago My dad is 90 years old and is in stage 7 of Alzheimer's disease. At the beginning of this year he was basically an unresponsive zombie. On April 1st I started him on NMN, NR, Resveratrol, Quercetin, Fisetin, and a few other vitamins. Today he is just like he was 4 years ago. The improvement is astonishing. I have to pinch myself every day to make sure it's not a dream. Sorry but trying to outsmart the science doesn't look good on you. And it's not very helpful to the public interest. 220 Reply Dr Brad Stanfield · 55 replies @nkolev @nkolev 2 months ago Again, NAD+ is NOT only vital for muscles - and this is your fixation: exercise! Reply @reinerheiner1148 @reinerheiner1148 3 months ago Nicotinic acid on the other hand does not only seem to increase blood but also muscle nad+ levels. Seems like the cheapest of all is the best one as well? Reply 1 reply @TatooedDoc @TatooedDoc 2 months ago So does this tell you that Nicotinamide Riboside also does not work? Reply @osirian8025 @osirian8025 3 months ago Well, they are trying to restrict it by making it a prescription drug like some other effective no side effect over the counter drugs. That to me an evident that it is probably working. Still in my second month and I can’t deny positive results but still early to judge. Reply @kenneth4970 @kenneth4970 3 months ago Amazing quality video Reply @electricpurple4112 @electricpurple4112 3 months ago Find you to be a little bit too obsessed with proving NMN’s usefulness as wrong. 😂 3 Reply 1 reply @gregariousguru @gregariousguru 3 months ago Man I'm sure loving this placebo effect. Reply @Streamlined955 @Streamlined955 3 months ago (edited) I’m not surprised. I’m a 53 year old regular exerciser and I saw no positive benefit from 6 months of taking NMN. Reply @robertakerfeldt3829 @robertakerfeldt3829 3 months ago Thanks for this! Reply @marjon888 @marjon888 3 months ago The only measure to change with NMN is a significant drop in the patient's bank account 1 Reply 1 reply @milkshakefrydip1671 @milkshakefrydip1671 3 months ago Man I’m allergic to creatine …what can I take instead ? Reply @seektruth9982 @seektruth9982 3 months ago (edited) Dr Sinclair owes his followers an apology and admission that he was wrong, not only about Resveratrol, but many other things as well like NMN. It's useless really, floating around the blood and not going into the muscles etc where it's really needed and beneficial. 5 Reply 1 reply @thorbenmeier3360 @thorbenmeier3360 3 months ago Amazing work! Very disappointing though. But it is good to know the truth. Reply @Hack3r91 @Hack3r91 3 months ago Unless Sinclair has been completely lying in the mice study, and that the main mechanism that works in mice would also work in humans, there's probably an issue with dosing. In that original study, mice got 400mg/kg/day for two months, which is almost two orders of magnitude above what many people are getting through supplements... Reply @mike.999 @mike.999 3 months ago 🙏 Good Information 🙏 Reply @anthonyschwarz2483 @anthonyschwarz2483 3 months ago Please quote the research papers, to double check on the statistical significance of them. Sadly a vast majority of medical doctors are missing this Part, hence more then 60 percent of medical studies are worth only as toilet paper. However I am intrigued to See if these papers you quote will prove to have a solid mathematical foundation. Reply @Tanikoshugo @Tanikoshugo 3 months ago @DrBradStanfield do you still recommend taking Apigenin supplements, or parsley? Reply @ejohn44 @ejohn44 3 months ago I notice you left out the dosage for most of the studies. The first study was for 250mg which is nothing. Most people take 1g to 1.5g and also take TMG. You're turning out to be a real disappointment... 6 Reply 1 reply @enaudeni @enaudeni 3 months ago But if I understood you correctly the studies were at a dosage of 250mg, as you say it is possible that it is been used up before it gets to the muscles. So if they ran the trial with higher doses 1 gram and above this should allow enough by the other processes with some to get through to the muscles. But these studies does not look at the whole MNM - NR - NAD loop as it should be recycled but due to increase in inflammation etc it gets used up. Reply @hikothe14th @hikothe14th 3 months ago We need human studies on significant IV NR or NMN doses (1 g or more) to really see if there's a benefit. Taking piss poor doses which get completely broken down to NA isn't going to show any effect, let's be honest. IV NR and NMN increased tissue NAD levels in mice in the Liu NAD flux study. 1 Reply @jowyckmans8818 @jowyckmans8818 3 months ago I have always suspicious on NMN and don’t take it! Reply @omar0bin0thabit @omar0bin0thabit 3 months ago Thank you for saving our pockets 😂 Reply @stevenpersamanos23 @stevenpersamanos23 3 months ago Also, does CoQ10 work? Reply @super_heroes @super_heroes 3 months ago I still take NMN. It’s changed my life for the better 8 Reply 7 replies @JacquesTreehorn @JacquesTreehorn 3 months ago Thanks. NMN is expensive and difficult to source. Saving money for retirement is better for overall health than wasting money on supplements that perform no better than placebo. If David Sinclair lives to 100 it will be because he is rich. 1 Reply 3 replies @muhammadathar2358 @muhammadathar2358 2 months ago David Sinclair claims it is revolutionary supplement and he must be awarded with Noble Prize fir it Reply @SC-bs7jd @SC-bs7jd 3 months ago Will save my money. Thanks Dr Brad. Reply @keipher42 @keipher42 1 month ago (edited) It's interesting that NMN has extended the lifespan of almost every animal model studied. Did those animal models show positive effects in any of the metrics for which you report the NMN results are disappointing in Humans. Perhaps the mechanism of longevity increase doesn't involve the metrics you cite. I also note that many of the supplements you now disparage you once promoted. It seems things changed about that same time as your little spat with David Sinclair. Both of you seem to me a bit driven by fiscal opportunities. I would love to find more bloggers who are outlining research in this area without seemingly searching for a paycheck. The best I've found is Eleanor of The Sheekey Science Show. Reply @2nkdav @2nkdav 2 months ago I’ve just had my NAD measured via whole blood sample after doing subq pure nad+ they have gone from 13 to 40…… something is working and this is not a precursor Reply @bestcomment3589 @bestcomment3589 3 months ago is david sinclair a bs artist? 3 Reply 1 reply @iamgoddard @iamgoddard 3 months ago The first NMN trial I found (Yoshino et all 2021) has results nowhere to be found in your review, it concluded: "NMN supplementation up-regulated the expression of platelet-derived growth factor receptor β and other genes related to muscle remodeling. These results demonstrate that NMN increases muscle insulin sensitivity, insulin signaling, and remodeling in women with prediabetes who are overweight or obese." Reply @Optimizedforlife @Optimizedforlife 2 days ago Why supplement with NMN when you can just take NAD+? Reply @XYZH1234 @XYZH1234 3 months ago How about Liposomal NMN ??? Would that not go straight into the cells? Reply @Elonsovich @Elonsovich 3 months ago (edited) If NMN raises NAD levels in blood, then why its not reflected on other tissues, like muscles, brain cells, etc? Reply @PomidorowaArmata @PomidorowaArmata 2 months ago * Someone discovers something with anti aging feature * Dr Brad Stanfield: CRITICAL FINDINGS, STOP TAKING, CONSIDER, PROBLEM, NOT WORKING 1 Reply @Shenteng1688 @Shenteng1688 3 months ago (edited) This guy used to be a fan of NMN. Later on, for some reason he is pissing off Dr. David Sinclair and his NMN. It appears now he is getting personal with Dr Sinclair. The bottom line is that this guy publishes his videos for money. So don’t take it seriously on what he is saying. I myself have taken 1g NMN powders everyday. I feel very good with it! I will continue taking NMN and watch this guy with a smile.😂 4 Reply @drkingslend @drkingslend 3 months ago What about the old mouse outrunning the young one after boosting its nad Reply @espenforfen1334 @espenforfen1334 3 months ago I don't expect any change in the things mentioned, all I expect is it might keep my cells in good condition. All the other stuff is just fluff. Reply @martinlundgren54 @martinlundgren54 3 months ago Broken down in the gut and liver... but does the raised NAD levels in the blood not contradict that? Reply @jp7357 @jp7357 2 months ago (edited) Interesting .. I have a great diet, I exercise daily, and get good sleep. My plasma icnad+ level was 28uM, after supplementing with 1g NMN it is now 96uM. I can honestly say I feel absolutely no differences in any physiological measure. I did full blood panels before and after and see no difference, I’m plant based and my lipids/hsCRP/mpo/a1c/eGFR/glu/insulin are amazingly consistent and extremely low (eGFR cystatin- c 120 adjusted for BSA) . I never expected any blood panel improvements although I did expect some exercise improvement .. I run 6mi/day but nothing improved (time, vo2max, hr, recovery time). No improvements in hearing or eyesight (as so often touted) and at 65 my hair is still depressingly gray. I’m most concerned about reports that NMN could “feed” cancer. I just got a glycan age test and it estimated my immune system age at 34 however they don’t put it down to nmn. I’m not going to change any of the 25 supplements i take just in case 1 or a combination is keeping my glycans youthful. 2 Reply @ausmiku @ausmiku 2 months ago As if we didn't already guess NMN was going to be yet another scam. There's so much health BS out there selling books or online subscriptions. Reply @chrisfrost3000 @chrisfrost3000 3 months ago He is completely cherry-picking information and not giving the full picture at all! Read the articles he refers to and see how far he goes in leaving out the whole picture, it’s shameful! When referring to glucose levels going up from before the study during the second month, they then drop below the Pretrail range! Same with body index and strength, he gives you the 6 week level which obviously won’t show much as the supplement is just beginning to be introduced! He is obviously just denouncing NMN to promote his own products…absolutely sad and shameful!!! 3 Reply 1 reply @melissahamm8122 @melissahamm8122 3 months ago Hi Doc,if NMN improves NAD,...now companies are coming out with NAD? IM getting confused, do we trust this? Reply 1 reply @PikaMemess @PikaMemess 3 months ago You didn’t cover taking it with resverstrol which is the whole point isn’t it? Reply @jdorman2583 @jdorman2583 3 months ago What about telomeres and microbiome? Reply @lj6087 @lj6087 3 months ago Isn’t taking NMN for increasing mitochondria function? That’s it’s link to longevity. All of the studies you mentioned had nothing to do with that Reply @txlongarm @txlongarm 3 months ago Haven’t you been taking and touting NMN, Doc? Reply @seektruth9982 @seektruth9982 3 months ago (edited) Attention everyone who claims they have seen improvements using NMN: Taking NMN is rather useless, it just floats around the blood but never gets enough of it going into the brain, organs, muscles etc to have any benefit. Those who claim they see improvements from taking NMN, keep in mind, there are a number of causes for this: 1. Coincidence, and you would have seen an improvement without NMN as the improvement was caused by something else, the human body or other lifestyle choice. 2. Placebo and "wishing thinking" is very powerful and can trick the mind to see and believe something which is not completely accurate. 3. The credible medical and scientific data contradicts any real benefits from taking NMN, so believe the medical and scientific facts, before you believe your own wishful thinking mind. 4 Reply 6 replies @TheAnzack @TheAnzack 3 months ago (edited) Saying that all influencers improvements is just due to diet and exercise is too simplistic reductive, it could be that there are benefits that studies haven’t captured yet. And I say that as someone that hasn’t tolerated nmn well at all Reply @suez1637 @suez1637 3 months ago Thanks for the bad review of nmn, it leaves more nmn for the rest of us ! It’s been a game changer for me, I am 57 years old and down to 122 lbs and the lowest body fat I’ve ever had in my life. I do pull ups and I can do 16 now in a row and 80 in 6 sets. I take 1200 mg a day and have been for 7 months. My whole life I’ve been in wanting to lose weight. I’ve never been able to get under 140 lb. My high school weight was 125. Being 122 with so much muscle and 6 pack abs was definitely due to nmn because I’m not even trying. It just happened. I tried really hard to get here in my 30s when I was a competitive runner. Now I just jog the dog, ride a horse and do pull ups and take nmn and I’m the fittest I’ve ever been at age 57. So anyway I don’t buy your analysis. I’m such a believer I bought 6 months worth and brought it to my mom who has Parkinson’s. The change in her has been dramatic. I can’t tell she has it anymore and she reports much more energy and other health benefits like her hair and nails have improved. One thing I feel strongly about is you need to take at least 900 mg a day. If you take less and say it doesn’t work that’s your error. And also it has to be high quality nmn of course. Reply @singlemommy7011 @singlemommy7011 2 months ago Any medicine to overcome shy bladder Reply @totallyraw1313 @totallyraw1313 3 months ago The take-home message: Most supplements are total horse manure! 1 Reply @Optimizedforlife @Optimizedforlife 2 months ago What's a good spermidine brand to take? Reply @gtn932 @gtn932 3 months ago Is this video and others meant to inform or just trying to knock down dr Sinclair’s work? If this is the case all your videos are biased and worthless. 4 Reply Dr Brad Stanfield · 1 reply @gad3iii532 @gad3iii532 3 months ago I can't wait to see how Greg Doucette tries to get around this with his super hyped VO2Max supplement. Not that it will matter, people will keep buying it anyways, but I get a kick out of watching. 1 Reply 1 reply @lissadawes4243 @lissadawes4243 3 weeks ago Great video Reply @joetart9905 @joetart9905 3 months ago If NMN were the Magic Molecule, the forces of evolution would have us seeking it out naturally. We would crave it, like water or food, or foods that have a high concentration of it. Reply 1 reply @mr.sharktooth @mr.sharktooth 3 months ago Thank you sir. Reply @avitarmagnus9090 @avitarmagnus9090 2 months ago It seems the science has yet to show why exactly we feel better on NR or NMN but feelings are science just not ready to explain it. Reply @ayeyebrazorf7527 @ayeyebrazorf7527 3 months ago Again, thanks for your service and cutting through the bulshit of David Sinclair. Please keep doing what you are doing Reply @wbhub @wbhub 3 months ago You've suggested following Charles Brenner, but he's just another social media influencer with a financial incentive to push NR despite any evidence to its benefit 2 Reply @Flymethereful @Flymethereful 3 months ago Further more, these studies have a few month trials, at best, why on earth it should be noticeable anything? Gait?? grip strength? When I first stated to take NMN it DECREASED my performance! - 3 years later, what I called "my training" I call it now "warm up", before hitting the gym for another hour. going to the beach for summer was a call for "inflamaging"... I truly think not even in my 30th I had this absence of inflamation. Reply @1billyjcraw @1billyjcraw 3 months ago Does NAD have to be in the muscle to have benefits? Reply @anonymous333 @anonymous333 2 months ago You really need studies that do involve older people, having it sublingually-administered , at a minimum dose of one gram per day, for at least 6 months before making any conclusions. Anything less than this, and you basically have garbage in = garbage out. They should mostly be looking at blood NAD levels, sirtuin activity, and epigenetic clocks. 1 Reply @centauri0 @centauri0 3 months ago Please do a video on Nattokinase please. Reply @MadisonPaige @MadisonPaige 3 months ago (edited) But who is taking NMN and boosting NAD+ levels for athletic performance? That’s not why I took NMN. (I stopped taking it and now take niacinamide for my NAD+ boost). IDK doc. You mention that it increases NAD+ blood levels but not levels in the muscle. Okay but I take niacinamide to increase NAD+ because levels drop as we age. So I’m good with increased levels in the blood. That’s what it’s supposed to be doing. Reply @click4biology @click4biology 2 months ago 34 years with swollen knee arthritis, all sorts of therapies and drugs that did not work..7 days of NMN and I have a new found mobility, reduced swelling, no pain....so whatever your agenda...it works for me, not to mention vision changes and alertness. No change to diet, sleeping or any of your other factors.......easy to make a name by being cynical about others experiences 1 Reply @mdso4365 @mdso4365 1 month ago We need brand recommendations, there are so many vitamin and supplement companies that are not putting in the bottle what it says on the label. You seem to be doing a lot of research and a lot of study. Can’t you at least give us a reputable brand name that your studies are done with. To simply say NMN is not doing much good, if you cannot tell us where the NMM is being purchased from so we can expect the results you talk about. How about it? Reply @stompugood18 @stompugood18 3 months ago Thank's for your work Reply @VictorTaelin @VictorTaelin 3 months ago 8:05 the disappointment was so big Brad turned SSJ Reply @marcusnyberg1214 @marcusnyberg1214 3 months ago This really doesn't mean anything if not the brand, storage temperature and storage time is considered in each study. Most likely has at least one study used NMN that has been storages warm or too long and therefore wouldn't have more effect than the placebo. If it is not declared, then that study have to be excluded from this list. NMN brands, and the short halflife must be considered for correct data. Please have this in mind next time. Thank you. Reply @guravi4295 @guravi4295 3 months ago how disappointing :( what about NMN injections? Reply @rdgjd @rdgjd 3 months ago This looks at increases in NAD+ through too narrow a lens. One of the most exciting potential benefits of restoring NAD+ to more youthful levels is supporting SIRT1 also SIRT2, the guardians of nuclear and mitochondrial genomes. Mitigating accumulated damage to DNA is a plausible mechanism for mitigating aging. I say “potential” because much more work needs doing to investigate this mechanism, but point is there’s more to increasing NAD+ levels than just overt and measurable physiologic benefits. When you change the oil in your car you get no immediately noticeable improvement in the “physiology” of the engine. But failing to change it is catastrophic. Reply @thorium222 @thorium222 4 weeks ago After reading the comments I must say that the positive reviews of nmn there sound exactly like some vitamin B defient people finally took some vitamin b, although the very expensive kind Reply @jeffthetutor9825 @jeffthetutor9825 3 months ago OK, so NMN is ineffective and harmless---as many supplements on the market probably are. So then why did the FDA ban it? 1 Reply @xilial @xilial 3 months ago (edited) interesting that so many comments report positive benefits after taking NMN, contrary to what is found by science. Perhaps the video should have also included who sponsored those studies or the criteria used to select the studies 1 Reply @thomk3282 @thomk3282 3 months ago What about niacinamide? Reply @larsnystrom6698 @larsnystrom6698 3 months ago We are disappointed! But Dr Sinclair will probably continue pushing it. I'm not surprised that NAD+ in muscles are more stimulated by exercise than of excessive doses of vitamin B3. But isn't it inflamation and such things as CD38 which consumes NAD+? I would guess that we should look at the NAD+ levels in everything having to do with the immune system, and the bodys repair mecanisms. These small and underpowered trials are not very conclusive, I think. Things like this would make me look further: "Treatment with the NAD+ metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality in aged animals, leading to restoration in fertility, and this can be recapitulated by transgenic overexpression of the NAD+-dependent deacylase SIRT2" If there are effects like these, I take it as a sign that NAD+ precursors actually does something! Reply @nasirahmad-jc3dt @nasirahmad-jc3dt 4 days ago thanks sir. Too good. Reply @ytsux9259 @ytsux9259 3 months ago I take ALL the supplements on the market (that's hundreds of supplements) just to cover all bases. I pop a supplement every minute of the day. I've turned into Superman. 💪 1 Reply @briandeadmarsh7538 @briandeadmarsh7538 3 months ago The results of these studies do not mean much to me because it is my understanding that a sirt-6 activator is needed to reap the benefits of NMN. In none of these studies did they give a sirt-6 activator to the participants. Reply @fidelio1566 @fidelio1566 3 months ago I agree!! Reply @rv8804 @rv8804 2 months ago Wasnt the NMN hype for antiaging? and the the damage to old cells? Not really about muscle performance? Reply 1 reply @Areweonfiya @Areweonfiya 3 months ago can i take niacin instead? Reply @xenofontzaras2741 @xenofontzaras2741 2 months ago So this studies on video shows, NMN supplementation increases NAD levels in the blood, but then it doesn't go to muscle cells, etc?? Where it goes then???? Reply @AthelstanSpilhouse @AthelstanSpilhouse 1 month ago After hearing this video I am going to dose with AKG rather than this supplement. I doubt we will get all the benefits a mouse does because the dose level most of these supplements produce is out of bounds for a human. Reply @drdex99 @drdex99 3 months ago Isn't nmn banned as a supplement? Reply @toto6257 @toto6257 3 months ago I’ve been taking NMN 500mg in the morning daily for over 2 yrs, but I don’t feel any improves with my body, and surly it didn’t improve my sleep quality and muscle mass at all. Thanks for the update! Reply @sircefiro @sircefiro 3 months ago Great vid, saved us some money haha, thanks Dr Brad Stanfield Reply @barrykp @barrykp 3 months ago I think the last assertion, that the gut absorbs it all, can't be correct, or it wouldn't raise blood NAD levels. Or am I misunderstanding? You should probably clarify that. Anyway I didn't know there was such hype around NMN and all the various health and performance metrics covered in this video. I just thought it was one of those things that is safe and might help me *live longer*. Does anyone really take it for performance or weight loss? None of this research tackles the fundamental question of whether it helps us live longer or not. I take it because of Sinclair's book: maybe it will somehow make me live longer. Checking whether a particular intervention helps people live longer is prohibitively expensive, so I guess that's why we have this random grab bag of research that looks at a bunch of other stuff. At best, this research rules out a bunch of potential mechanisms by which NAD boosters might work. NMN is still in this category of things: "nobody is ever going to properly test if it really helps people live longer, but it's safe to take so it's your money". Reply @Sophal27 @Sophal27 2 months ago NAD+ is just a marker of metabolic health. It tends to go down with age in parallel with metabolic health. Putting your thermometer in cold water won't improve your fever. If you want to improve your metabolic health you have to work on your nutrition, your strengh, VO2 max, your mental and stress equilibrium. Reply 3 replies @degmddgmdpa5572 @degmddgmdpa5572 3 months ago Is clinical science really up to the issues being pursued here? Reply @mrufino @mrufino 1 month ago The title of the video is misleading. It seems these 12 studies don't address the "anti-aging" effects of NMN, like the boost in the action of sirtuins and the maintenance of epigenetic stability. Despite the relationship between age reversing and athletic performance, they are not the same thing. Reply @SevenCostanza @SevenCostanza 3 months ago Thank you for youre service Reply @EricCosner @EricCosner 3 months ago I don’t be believe NMN works unless conditions are right for it. If a person doesn’t exercise or take other signaling compounds, it probably isn’t helpful. Also, I thought the idea was to slow aging. Slowing aging doesn’t necessarily mean improving anything. Isn’t NAD mostly just needed for DNA repair. It’s very hard to measure something like that in the short-term. At least these studies suggest that it’s safe and if it’s increasing blood NAD+ well then how is that different than getting an NAD injection? We know exercise helps promote the recycling of NMN. Maybe some of us respond differently to it. I’m currently in Hawaii, just went through all the stress from the situations going on here and I’m running further than ever. Is it the NMN combined with that stress or is it just that Hawaii is amazing. 😂 Reply @stevenbelzer9768 @stevenbelzer9768 3 months ago Brad , NONE of these 12 studies findings addressed NMN effect on cellular DNA methylation or PACE aging rate . THOSE TWO are the relevant contribution of boosting NAD levels in individuals 35-90. The ONLY human study worth examining would be a long term study on incidence of “age related diseases/hallmarks of aging - this study didn’t even look at insulin resistance /metabolic syndrome over time using NMN with a type 2 diabetic study population . NMN ain’t a molecule that will affect “body composition sleep patterns 😂 Reply @Girlintherocket @Girlintherocket 3 months ago What IV vitamins would you use Dr Brad? Reply Dr Brad Stanfield · 1 reply @Tara-zq3il @Tara-zq3il 3 months ago (edited) Is the NMN administered with an activator such as Olive Oil ?Because as i understand it it won't otherwise work ??? Reply 4 replies @rosem4741 @rosem4741 3 months ago I knew this was a waste of money, I see no benefits at all after 8-9 months of daily intake. Still have very low energy, cholesterol is higher, no increase in muscle mass. I’m a fairly fit female who walks for 1.5 hrs a day and at an ideal weight but energy has been so low last 2 yrs and I see no difference with nmn. I also take tmg and berberine and still no better 1 Reply @mag4926 @mag4926 3 months ago (edited) WHY don't you talk about NAD Clinics in any of your videos where people can get NAD+ IV Infusion Therapy❓ Is there a reason you don't talk about it, or is it just a coincidence❓ How about making a video about these NAD Clinics with all their Benefits regarding NAD Therapy❓ I think that interests some people... Reply @CraigHocker @CraigHocker 3 months ago This really isn’t surprising. There is lots of hype and wishful thinking in the longevity field. This summary from a few years ago still remains true. “From our research we also are not convinced that nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) offer good value or actually deliver on their intended goals. Studies in the 1990’s found that NAD+ and other molecules in our food are broken down into niacinamide before being absorbed. NAD+ in food, as an example, was first broken down into NMN. The NMN was then further broken down into NR. And the NR was slowly turned into NAM during digestion. A small amount of this NAM was turned into NA by gut microbiota. So it was NAM (and to a much lesser extent NA) that was absorbed. Until information exists showing that the NR and NMN molecules can make it past digestion and the liver intact, we think these are very expensive ways to do something the other niacins do.” 1 Dr Brad Stanfield Reply @HarryJensen-kr4qz @HarryJensen-kr4qz 3 months ago I take NMN to lengthen telemeres, no other reason. Reply @HypnoticValentino @HypnoticValentino 3 months ago (edited) This is not what we take NMN for. Following the metrics of these studies, coffee would be the best substance to take. Reply @mickmickymick6927 @mickmickymick6927 3 months ago Great. Please more of this and less of the clickbait. 2 Reply @jamiel3902 @jamiel3902 3 months ago Niacin flush is the NAD king. Reply @justingirard7476 @justingirard7476 1 month ago I have no clue why NMN is being studied against any metric other than DNA methylation. The primary purpose of supplementing NMN is to improve ageing, which has to me measured over months and years, and anyone looking to measure it against any time window < 24 weeks, with low dosages, is just not studying it properly. OF COURSE it is going to have a negligible effect on strength, stamina, LDL, HDL, and all of these markers. The primary use of NMN is to make sure NMN is used as part of DNA repair. Second point, DNA repair is upregulated during fasting. In my mind, only studies that supplement NMN during fasted periods (or calorie restricted periods) will be expected to succeed. Specifically, humans are over fed, and the mechanisms NMN is designed to help with up regulate during a calorie or energy deficit. Again, these studies seem to leave this CRITICAL design factor out. To create a metaphor, NMN is like a salve, that helps injured tissue heal during protected rest. I have no clue why this "DNA ointment" is being tested for its ability to make you run faster, or lift more. Its also tested in a context where the body is not in repair mode. So, these findings all are strange, because none of them measure what we are looking to measure. However, I do understand -- Imagine running an NMN trial for 6 months, with people who dose when fasting, and then taking regular DNA methylation tests. This would be an insanely expensive trail, and would have very low compliance. So I get that the researchers decided to go with easy to measure proxy metrics. However, nobody should expect these proxy metrics to relate much to the underlying variable we care about in the short term: DNA damage. Reply @saradoherty3875 @saradoherty3875 3 months ago the hair at the side of my head has turned from greyish to dark brown same with my eyebrows this is observable please tell me how this can be a placebo effect Reply @proto.yami.official @proto.yami.official 2 months ago Literally anyone over 35 who has taken NMN will tell you how life-changing it is. People, it was banned because it has potential to be a prescription. NMN is legit regardless of Brad's video. I fw Brad but he's imperfect. Stay woke Reply @milesvanrothow2067 @milesvanrothow2067 3 months ago I tried NMN and found no apparent benefits. Reply @Flymethereful @Flymethereful 3 months ago Applying the same metrics Brad uses for NNM/NR to all other supplements he promotes ... and he should close the channel altogether! 2 Reply @petertodorov1792 @petertodorov1792 3 months ago Dear Dr Stanfield What do you think of Dr Nichola Conlon’s Nuchido TIME + that she is selling? Reply @karoliinasalminen @karoliinasalminen 3 months ago And.. all of the studies used very low amount of NMN and no other synergistic supplements which may potentiate NMN. Because if the dose is large enough, anyone can gain anecdotal evidence of what NMN or NR does. 2g of NMN + some NR + 2g of Fisetin together actually produce acute effects which are surely feelable. However, the effect is short-lived, only lasts for up to tens of minutes or even shorter than that. The effect can be restarted by taking more NMN while the fisetin is in effect. But it is short lived again. Enough anyway to be able to run a short run. I would claim that based on the anecdotal evidence with high dose NMN supplementation, it is bioavailable, but for very short time, and also requires a large dose to have an effect and also requires other supplements to synergistically potentiate the effect. There are many supplements which do not work alone, but as a cocktail they do. For example one could eat 10 grams of l-tyrosine and feel nothing at all, but taking few other supplements as well at the same time, will help its conversion to l-dopa and then to dopamine. With the cocktail it is possible to produce a significant dopaminergic effect which the l-tyrosine alone would fail to do. Similarly than with the NMN alone, probably does not work alone. Also question is, is the effect beneficial enough with NMN to do it for the short boost or is that just in vain in the long term perspective (ie can help for example excercise for a short moment, like a turbo-boost, but it is possible that it has no other benefits than the acute effect which only occurs at a large dose and a combination). Is it worth it for its acute boost alone? Not sure, it is quite mild even with the large dose. Reply 1 reply @gz625 @gz625 3 months ago SINCLAIR was a main NMN and resveratrol sales booster with his scam studies 😂 At least he earned a ton of money... 1 Reply @earx23 @earx23 2 months ago (edited) While I'm aware that I just may have bought some caffeine powder posing as NMN, at 1000 mg a day this stuff elevates my mood and keeps me up 20 hours in a row.. I'm normally pretty sleepy throughout the day. Taken sublingually it gives an immediate boost. UPDATE: I've seen the effects on mood and energy now last about 30 hours. There's no caffeine pill or amphetamine that can do this. Furthermore, it seems the effects accumulate ("stack up"), which definitely points to it being a mineral or vitamin (NMN is a precursor to vitamin B3 anyway). So, either it's a placebo, or I'm taking the real deal. And if it's a placebo, that's one hell of a placebo! 1 Reply @jacksonitsme @jacksonitsme 2 weeks ago how long are these studies actually conducted.🤔 Reply @carljacobs2901 @carljacobs2901 3 months ago NAD declines with age LIKE HUNDREDS OF OTHER compounds in the body!!! Trying to shore up NAD is at best addressing a symptom, not the cause. What about NAC levels? What about declining Testosterone and growth hormone? 1 Reply @keywestfan2503 @keywestfan2503 2 months ago “Thanks man. There goes my beach house” -David Sinclair Reply @joannsmith9 @joannsmith9 3 months ago (edited) Does RAPAMYACIN improve cholesterol, body composition, grip strength, muscle performance, NAD level, cholesterol, etc,etc,etc,etc?? IF IT DOESN’T WHY TAKE IT? Millions of us take it and benefit from it. You have partial knowledge about NMN Reply @nocturneprimitive @nocturneprimitive 3 months ago Testing NMN in young people who already have high NAD+ is pointless. Please make a summary of study results that actually matter. Reply @sandradeterman8922 @sandradeterman8922 3 months ago (edited) Glad u didn't find any value. None of the studies touched on the reasons that I take NMN, so they don't mean much to me. The value I get from NMN is high, and if no one else buys it, it will keep price and supply low. Thanks again :) 2 Reply 1 reply @ClassicalLiberalWarrior @ClassicalLiberalWarrior 3 months ago This video is very important. But it takes its eyes off the prize. The various health effects of N.M.N. are NOT very important. The only question is: Does N.M.N. enhance HUMAN LONGEVITY? It seems to work in mice and other creatures. I also want to know: Why does Dr. Stanfield still take niacin (as I do)? Reply @shus5787 @shus5787 3 months ago What are your views on nuts, a lot of conflicting info from different doc's 1 Reply @s210454 @s210454 3 months ago nice vedio with scientific references. I take nmn, only feel dizzines and tired. I'm still observing the results Reply @andrewwalker8985 @andrewwalker8985 2 months ago How is this not just misrepresentation of findings. Paper number 3 discussing their own results “The main finding of this study is that NMN supplementation during exercise improved first ventilatory threshold (VT1) and power@VT2 without changing the VO2max and that this improvement was dose-dependent.” You simply list things NMN didn’t do, say it was a disappointing finding, when the paper reports significantly improved performance. WTF mate Reply @user-yp4dy8bl3l @user-yp4dy8bl3l 2 months ago Is it placebo effect. Are there double blind clinical trials? Reply @mpen7873 @mpen7873 3 months ago 12 papers. Great effort. Excellent work. Thanks 👍 Reply @looney76 @looney76 3 months ago I took NMN for a year, and didn’t feel anything, so stopped after my annual subscription ended. Reply @aussiet8001 @aussiet8001 3 months ago (edited) this guy likes to ‘disprove’ any of David Sinclair’s research. He can usually be found debunking someone else’s theories. 2 Reply 1 reply @dmpag7000 @dmpag7000 1 month ago most of us take NMN for its antiaging potential - This wasn't addressed in any of these studies. Also, I've been reading "scientific" journals for more than 40 years and find much more crap than fact. Any study that doesn't have at least a minimum 0f 100 age-matched subjects in group is worthless. Drawing any conclusion from a sample size of 10 is ludicrous. Reply @DaddyEZ545 @DaddyEZ545 1 month ago Wow! Bummer! Ive been taking it for a good 8 months Reply @unholyquail4560 @unholyquail4560 3 months ago (edited) The real aim of NR/NMN supplementation? To keep NAD+ level to healthy youthfull level as ALL studies prooved it did. From there reducing the amount of damage our our epigenome and the loss of information over time by damage and sub par repair due to low NAD+ levels. So what does your meta review actually show? Yes it increases NAD+ therefor the amount of NAD+ available and it combats the decay in NAD+ levels that lead to problems in the long run. So it does exaclty what it is suppose to do. The problem? People are testing it as an intervention against existing pathology or performance enchancer. Sorry but that isn't the theory and the application of the theory. That is just wishfully thinking to find that Panacea drug. What does this video show? Again Dr. Stanfields limited ability to actually keep to theory and application of theory to practice instead of going down to MD level of thinking where intervention = cure or = direct effect. No... Stanfield still approaches supplements like these in a medical 2.0 model (Peter Attia) instead of the medicin 3.0. Not direct intervention to get people back from injury or damage. No the prevention of damage in the first place keeping the information at bay. Personally I apply medicin 3.0 for years now. My Epigenetic age is 6 years younger than my chronological age and that is almost 20% of my current cronological age to start with. I have been using NMN and NR for 4 years now and the gap between epigenitc age and chronologic is only increasing. Because the Epigenitic seems to move extremely slow compared to the chronologicv one. I cannot claim causality to the NR and NMN. What I can show is me adhering to the medical model 3.0 is reaping significant benefits. That is the point Standfield is missing and the theory and new practice which in every video he seems to be missing the mark. It is about even preventing the decay (entrophy) to take hold. Not to treat something that is already damaged. That is not what the field of healthspan and longevity is about. Get out of your MD training theory medical model 2.0 and start to also see the prevention element of it Stanfield. You claim you read the relevant literature but it seems the point went over your head so far because your training does not allow you to look further. I would refer people to Peter Attia for a explanation of medicin 3.0 and the centinarian decathlon to apply to their lives. Where I would recommend Sinclairs work to actually understand why and how these new range of intervention supplements can actually support us in that journey. Reply @milosdimitrijevic5694 @milosdimitrijevic5694 2 months ago This is ok, but what about dosage of 2000mg, that everybody takes? Reply @justinmanchester7743 @justinmanchester7743 3 months ago Love the skepticism when all the research has shown that it increases lifespan which is why people should be taking it. But thanks anyway. Reply @earx23 @earx23 2 months ago I'm sorry but I'm reading more of these publications now, and Dr Stanfield just cherry picks everything that's negative about them. The amateur runners on NMN did actually achieve a higher ventilation limit and improved single leg stance. This corroborates all the anecdotal evidence found here and on reddit. NMN doesn't help with strength, but it does help extend aerobic performance.. Some people claim they can run or swim twice what they could do before. Reply @user-og7rm3si1e @user-og7rm3si1e 3 months ago going by dr brads metastudy and contrasting that with the pro nmn comments it appears for someone who is already fit there is no advantage in taking nmn 1 Reply @N330AA @N330AA 3 months ago If you look at the study, increases in insulin were not statistically significant at the 3 month mark. As always though you like to cherry pick which studies matter and which ones don't. 1 Reply @psteffensen @psteffensen 3 months ago What about Nuchido? I am curious. 1 Reply 1 reply @heidiantros1856 @heidiantros1856 3 months ago I personally don’t have an opinion about the efficacy but these “studies’ are comically small. You know better. A study of ten men, then 48. That’s not really representative of a cross section of human beings. You also have to consider where (in what forums) these studies are published and by whom. Reply @RJay121 @RJay121 3 months ago This Dr is the only honest reviewer on the net. We'd be wasting millions without him. He's called out rip-off David Sinclair bs. Ty doc❤ 2 Reply @MrChesterification @MrChesterification 3 months ago thank you!! Reply @ratherrapid @ratherrapid 3 months ago raising again the Q--is there a researcher on the planet with an ounce of common sense. Did any of the NMN pros ever say that NMN was going to increase grip strength, body mass or all the irrelevant things everyone of these studies seems to have tested for. NMN supplementation for a person that already has all the NAD they need, how could there possibly be a benefit The benefits originally touted were that NMN would get into the NAD deficient cell and aid the mitochondria. Since they claim that NAD declines with age, there must be a way to measure this. So the simple test, does NAD improve within the cell with NMN supplement? The initial claim was that NMN increased mouse life span, energy and appearance. Any of these "researhers" ever try to duplicate this claim in a lab, etc. My own high dose NR experiment over lenghty periods was an initial overall energy boost that seems to subside over time, possibly improved skin and I would notice some gray hair darkening. i was never at age 75 tired when taking NR but in the end was it due to NR--I did not know. I quit when I understood the cancer risk. Reply @KGB_Putlir @KGB_Putlir 3 months ago table breakdown so nice quality i like Reply @antoniobortoni @antoniobortoni 2 months ago The only thing that would matter in those studies is cellular metabolism, whether it increases or not, right? That is what youth is... How a person feels is very subjective, hence the placebo effect. All yogis state that behind everything is mental energy, what you believe. If you believe you will gain weight, it happens; if you believe you will lose weight, it occurs even without dieting. The power of the mind over the body is extremely potent, hence the placebo effect... but the cell speaks. If you take NMN and your cellular metabolism increases, it's because it works... Reply @0xszander0 @0xszander0 3 months ago I am quite surprised by this video. Since you are not talking about the benefits these studies founds at all. Because nmn doesnt increase muscle nad it doesn't mean it has no benefits for your workouts. It could for instance have massive impact on fatigue and or your nervous system. We dont know many of these mechanisms yet you are right. But because we havent figured out the mechanisms yet it doesnt mean it doesn't work. I really find you too black or white in interpreting studies. Glossing over any massive benefits found. NMN lowers inflammation in the body, we know this factually for instance. Reply 1 reply @ocoro174 @ocoro174 3 months ago what about lipo nmn? Reply @gregbartlett5818 @gregbartlett5818 2 months ago (edited) Hmmm...no questioning the trial parameters just read the result and quote the answer as gospel. David Sinclair has said most of the trials have not got a high enough dose for humans (should be 1000 mg +) nor have been long enough especially in younger groups. I noted that one trial he quotes used a dose of just 250 mg a day. Pointless. Reply @ScottSummerill @ScottSummerill 3 months ago Bummer but you’re likely correct. That said, better clue in David Sinclair before he wastes any more money developing his new drug. Reply @donwinston @donwinston 3 months ago What ever is going on between your ears is a very big factor in fitness. Reply @johnb9942 @johnb9942 3 months ago 13 March 2023 NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury Reply @rfbead321 @rfbead321 3 months ago Thumbs up 👍 Reply @richardprice9730 @richardprice9730 2 months ago Great your starting to impress me. Reply @angeladavies @angeladavies 3 months ago I will save my money for nutritious food. Exercise, sleep and creatine. Thk 2 Reply @xctcxggg3318 @xctcxggg3318 3 months ago 02:57 Thats not free fat mass - that's fat free mass Reply @shrimboi8909 @shrimboi8909 2 months ago The thing is any studies can be manipulated. I don' know if this stuffs any good but I'm taking it anyway. Reply @hmsd4450 @hmsd4450 3 months ago 53 - tired and sleepy, take 500mg … Boom - 1 Hour later I‘m walking in the Woods for hours Reply @roqclimber @roqclimber 3 months ago So, what you're saying is, The Secret to a longer, heathier life is: Exercise, a Health Diet, and a good night's Sleep. Who knew? Reply @okamsug @okamsug 3 months ago That's true with many supplements. Just a lot of hype, promo for business and placebo. Reply @felicisimomalinao1981 @felicisimomalinao1981 3 months ago Right. I did not take the high-priced NMN. Reply @frankerororo @frankerororo 3 months ago What does sinclair say about your analysis? Reply @giannidiolosa8804 @giannidiolosa8804 3 months ago I take NADH and B3 Reply @mindtemp-yourdigitalcoach @mindtemp-yourdigitalcoach 3 months ago Thanks ❤ Reply @rosiefoster713 @rosiefoster713 3 months ago what about SIRT6 ACTIVATOR? Reply @minds5 @minds5 3 months ago But what about the mouse that regenerated? Reply @TexasNightRider @TexasNightRider 3 months ago Glad I didn't order NMN because it is not cheap. I take enough snake oil as it is. Reply @pablogomez4959 @pablogomez4959 3 months ago but maybe it helps with genetic stability and epigenetic stabilty through sirtuins 1 Reply 1 reply @billydee1879 @billydee1879 1 month ago I take 500mg niacin time release before bed every night. Reply @MrVladanbajic @MrVladanbajic 3 months ago It looks like that the placebo effect has medical properties...this should be looked into...placebo might be manageble.... Reply @jantestowy123 @jantestowy123 2 weeks ago I take it with resvertrol, I think as you should.... Reply @davidwest5177 @davidwest5177 3 months ago Hey Dr Stanfield are you familiar with Nuchido Time and Dr Nichola Conlon?? Would love to hear what you think. Reply @scottdickieson9019 @scottdickieson9019 3 months ago Hey, What about NR as a supplement? Reply 1 reply @shaneroelofs9800 @shaneroelofs9800 3 months ago Any updates on CD38 inhibitors? Reply 1 reply @larrygarms7230 @larrygarms7230 3 months ago I use it. No one wants to be in the control group. 1 Reply @TheOfficialBullyMaguire @TheOfficialBullyMaguire 3 months ago I find it funny that Do Not Age has given money to your research but many of your videos are bad publicity for them, simply due to the fact that they sell many things you dont endorse (like NMN and Resveretrol) lol 1 Reply @stephensmith9052 @stephensmith9052 2 months ago That is nmn .Test studies for NAD+ ? Reply @misanthropiclowlife @misanthropiclowlife 3 months ago Ik a little upset with the channel, doc. I buy creatine because of your recommendation only to find out it has a correlation with testicular cancer Reply @alexman128 @alexman128 2 months ago Does anybody know how to get nmn in Mexico? Reply @brycebarbato7203 @brycebarbato7203 3 months ago Oh boy. I feel like you just opened up a can of worms. 😂 1 Reply @keithdow8327 @keithdow8327 3 months ago $10.00 Thanks! Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply @emileimilheitor3456 @emileimilheitor3456 3 months ago Excuse me, I failed to understand in which laboratory you were working on, and which paper or research you've conducted... oh wait Reply @MrJohnson57 @MrJohnson57 3 months ago From an earlier post about Dr Dray agreeing with Dr Stanfield’s read on NMN: https://youtu.be/5Nq0OYLcNE0 Reply @naturalfacelift79 @naturalfacelift79 3 months ago Doses in all studies are very low and duration too short. Reply @gtf600 @gtf600 3 months ago I hear it works better if you just buy the damn cook book Reply @DuderofDudeness @DuderofDudeness 3 months ago Costs too much for too little 1 Reply @breatheased @breatheased 3 months ago Anything on the effect of skin? 1 Reply 1 reply @topguy4uok @topguy4uok 3 months ago David Sinclair got a lot of 'splaining to do Reply @Cagebreaker21 @Cagebreaker21 3 months ago "Slow walking speed, so I'm just going to exclude this" = cherry picking 2 Reply @ballapalleballe @ballapalleballe 3 months ago you forgot a column specifying dosage in your matrix! Reply @thomasm9461 @thomasm9461 3 months ago I take nmn, saw all benefits before even knew that these benefits exist. Also, who can tell me if big pharma dont want to sabotize this? I would rather follow Sinclair and Huberman than any other nobody, sorry Reply @davidprice8545 @davidprice8545 3 months ago Doses are too low in these studies Reply @tomballey8906 @tomballey8906 3 months ago I would like yo congrat u, amazing work Reply @paulcohen6727 @paulcohen6727 3 months ago David Sinclair strikes out again. Why am I not surprised? Reply @keithdow8327 @keithdow8327 3 months ago $2.00 Thanks! Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply @bestcomment3589 @bestcomment3589 3 months ago brad please do vids on Urolithin A 1 Reply 1 reply @theatheistpaladin @theatheistpaladin 3 months ago Niacinamide is good enough and cheap. No need to by the expensive NMN stuff. Reply @HAROLD-CORE @HAROLD-CORE 3 months ago I'm wishing I didn't spend so much money on it. It makes me flush terribly as well, I'd rather not take it. Reply @allenwestee8364 @allenwestee8364 3 months ago I thought that they took it off the shelf? Reply @rahilakhadem5753 @rahilakhadem5753 1 month ago please need your help my daughter takes NMN all longavity supplements now she pregnant she can continue with supplements or stop it her GP not sure thank you Reply @pepesmama7515 @pepesmama7515 3 months ago (edited) Will you take nmn? Reply @fk9277 @fk9277 3 months ago I wonder wtf is going on with the mice then. Reply @LuanJunyi @LuanJunyi 3 months ago Even before watching, I know the result is negative ^_~ 1 Reply 1 reply @masaru2000 @masaru2000 3 months ago Your video denies every recommendations by david synclair, nmn, metformin, resveratol, protain intake. Very interesting. Reply @jacobdahl7747 @jacobdahl7747 3 months ago Dr Brad. Since there are no side-effects. Why not do an honest 2 months-trial and see if you see any effect. People have so many different experience with it. You stand and talk and talk... put you self on the field. Reply @jacobdahl7747 @jacobdahl7747 3 months ago This is so contradictiv to my own experience and others. 1 Reply @ziyaonbashi5864 @ziyaonbashi5864 3 months ago So you are saying NMN and NR are totally useless?? Reply @user-md2et1yr3v @user-md2et1yr3v 2 months ago How can I get in Nepal Reply @jaisango @jaisango 3 months ago In two months this dude will be saying he don't take it no more.. he changes his mind like a baby changes diapers. Reply Dr Brad Stanfield · 1 reply @OscarCuzzani @OscarCuzzani 3 months ago Disappointing results indeed. However, the title of the video refers to reverse aging and increase lifespan. None of the studies referred to this. Reply @Mattbriggs85 @Mattbriggs85 3 months ago So has no effect on endurance. So what does have an effect on endurance. Reply @bzpwhx @bzpwhx 3 months ago I got NMN for a while and did zero to me. Go to the gym and be on a zero carb diet your life will be a lot better. Reply @dukedex5043 @dukedex5043 3 months ago When you said you have taken any men, I was worried. Reply @valerieash5108 @valerieash5108 3 months ago I thought you can’t buy it anymore? Reply @ezl6307 @ezl6307 3 months ago Methylene Blueee??? 😅 Reply @sunnydays5581 @sunnydays5581 3 months ago Im new to MNM and before i purchased , i researched extensively, to ensure i got what i paid for. This industry, as lucrative it is, seems to be a magnet for scammers. In saying this, and if infact true, your conclusions are flawed, because you dont name the MNM brands, nor are they tested for purity. I hear there are some products out there that are not even NMN, just mimick its taste and texture, others diluted , some pure and batch tested. NMN is not easy to make, so It makes sense given how varied the benefits are in comments Reply @embersandash @embersandash 3 months ago Subbed. Reply @michaelcascio6346 @michaelcascio6346 3 months ago Thanks Reply @thanosisback2754 @thanosisback2754 3 months ago Niacin is king Reply @gpwil3847 @gpwil3847 3 months ago So NMN is a bust for Human subjects. Thanks. Reply @seban-jackedweeb5513 @seban-jackedweeb5513 3 months ago FOR THEE ALGORITHM!!! Reply @danieldipietra2307 @danieldipietra2307 3 months ago You seem to approach this subject in non objective way. In this video you’ve focused on muscle. How about nmn effect on organs/brain?? Reply @luckyhanger1326 @luckyhanger1326 3 months ago Not a fan of NMN, most of those parameters are long term, arterial stiff ness, now long doe it take to get stiff arteries? How long do you think it takes to clear. How do you know everyone taking NMN is eating healthier and working out? I agree with you that NMN is a not great longevity supplement, you failed to discuss any shortcomings in the studies. Spin it how you want, back to the ignore list with you. Reply @hannahyun0 @hannahyun0 2 weeks ago is any reason between you and NMN ? Your sounds very personal against NMN? Reply @darrenbeutel6849 @darrenbeutel6849 3 months ago It’s safe because it doesn’t do Sh*t Reply @jeronimomartinez5087 @jeronimomartinez5087 1 month ago until now most of research said about nmn is not proven. Reply @friederichrex9622 @friederichrex9622 1 month ago All 12......not all 16? Reply @AH-gk6qs @AH-gk6qs 3 months ago Honestly, I am not surprised Reply @carolannsierra122 @carolannsierra122 3 months ago So what works NAD Reply @danieljrgensen133 @danieljrgensen133 3 months ago Sinclair did say, that NAD boosters are mostly for "older people"(+60 yo)...as natural levels decrease with age! I see a lot of young people commenting everywhere....did they not even bother learning the basic "Sinclair theory" behind these supplements! 😄👎 Reply @matzefritz @matzefritz 3 months ago Wierd video. I have been taking nmn, it works well for me. Reply @deltawhiskey1398 @deltawhiskey1398 3 months ago So basically...it's useless. Reply @gabymalembe @gabymalembe 3 months ago I like Brad’s posts, but he seems obsessed with trying to one up David Sinclair. 1 Reply @user-fm3dt8yj3f @user-fm3dt8yj3f 3 months ago 250mg is not a adequate dose either Reply @andrewwalker8985 @andrewwalker8985 2 months ago Sorry this isn’t reporting on science, it’s picking single sentences from studies that match your opinion Reply @CambiamentoeRisultat @CambiamentoeRisultat 3 months ago And so David Sinclair's Studies Are Wrong? Reply @douglascuthbertson3595 @douglascuthbertson3595 3 months ago Everyone, do you notice Brad only likes the comments about him and not the people who is benefiting from NMN. Brad is biased to NMN 100%. I keep noticing the first comments are always more favourable to Brad 🤔 I don't trust this guy 100% .... 1 Reply @Ibanezyt @Ibanezyt 3 months ago Studies ignored or missed by Dr David Sinclair who seems in favor of NMN? Reply @michaelz8620 @michaelz8620 2 months ago Based on a lot of the comments I’m reading it appears the studies and science you’re referring to are not very reliable! Reply @slobodanfuletic9465 @slobodanfuletic9465 3 months ago Just stick to Niacin and Niacinamide combo Reply 1 reply @Cenot4ph @Cenot4ph 3 months ago NMN is si expensive, ill stick with carnivore for energy and good B vitamin levels Reply @davidderidder2667 @davidderidder2667 2 months ago 250g is too low. I take 1000 mg a day 1 Reply 2 replies @ritsukohairsalon @ritsukohairsalon 3 months ago It got norhing to do with nmn. Haahahaha...take that Sinclair. Reply @NuanDaa @NuanDaa 3 months ago 8:05 hairstyles changed slightly 😃 Reply @terrymokihana1421 @terrymokihana1421 2 months ago You take on various studies to justify your latest opinion is also very "preliminary" Reply @discotex2236 @discotex2236 3 months ago Eat right and exercise, same old same old! Reply @peterpooe3145 @peterpooe3145 3 months ago (edited) Big pharma advocate, NMN not good for big pharma and their distributors profits Reply @sviridovsergey7055 @sviridovsergey7055 3 months ago Как так то? Reply @ryanoliver1900 @ryanoliver1900 3 months ago I enjoy these informative videos however they seem to go from positive support to negative warnings from different videos. So very unstable and confusing. Time to take a break. Reply @jakeb6043 @jakeb6043 3 months ago Mouth piece Reply @boossersgarage3239 @boossersgarage3239 2 months ago NR, NMN, taurine, suritin 6 activator, b complex, quecertin, reseratrol, magnesium, collagen, creatine, K, C, fisetin, D, TMG, AKG, NAC, I feel and LOOK 10 years younger, the studies he is referring too are misguided and narrow minded. I'm not going to stop taking any of these things until I have completed my own Research.... 1 Reply 1 reply @timmyhiggins5220 @timmyhiggins5220 3 months ago So it doesnt work then Reply @quaterman1270 @quaterman1270 3 months ago Almost all studies had a dosage of 250mg to 300mg. That's way too low for 50 to >60 years old people. I don't unerstand why you don't get into detail regarding the right dosage... Doesn't seem like much effort to me. 1 Reply @Philly1958 @Philly1958 3 months ago Eat meat (beef) and exercise Reply @seekfactsnotfiction9056 @seekfactsnotfiction9056 3 months ago You must be paid by the big pharma 1 Reply @carole3445 @carole3445 3 months ago What do you believe? Reply @ralphprice7365 @ralphprice7365 3 months ago (edited) None of this research is long term. 1 - 6 months does not necessarily prove very much. Researchers now seem to want quick results and do not put in the effort (aka funding) to find out how the body responds long term. Additionally, there might be other benefits that have not been measured. But, overall the social media nonsense is just that; unproven claims. Reply @jonathanantoine4962 @jonathanantoine4962 3 months ago Have you try to get David Sinclair to comment on that? What he has to say to defend those results? Or do you think at this point he is just a charlatan? Reply @ryanpuryear @ryanpuryear 3 months ago Hear that @gregdoucette? 1 Reply @joeblow1748 @joeblow1748 3 months ago Well whats the point of this channel then? If all you can bring to the table, just be healthy and exersise. Tell me something i dont know... Reply @johnmenezes2031 @johnmenezes2031 3 months ago (edited) Not sure what the point of this video is other than to attract views with the title. He also sells his own supplements ($49/bottle of a multivitamin that throws in things like hyaluronic acid (for skin? no real benefit orally))so bias should be considered. NMN, NAD, Nicotinamide riboside have been investigated as benefiting longevity via the SIRT pathway (similar to calorie restriction), and show a benefit in lab studies. He doesn't review any of those. Also none of the human studies study longevity to date as this takes a long time. The one study looking at energy / metabolism and insulin sensitivity did show a benefit. Anyone can cherry pick studies to make a point. I don't know that anyone takes NADR to lose weight or change their blood pressure. The conclusion of many of these studies is that more study is needed in the human clinical setting. Variations in health status, age, diet, exercise level will confound results compared to laboratory/animal studies. I am neither promoting nor bashing NADR supplements. I don't think there is an answer yet. There is better data on Human Growth Hormone, Gly/NAC, Taurine, and Vitamin D as being beneficial. Also I am an MD too. 1 Reply @fugenturkoglu @fugenturkoglu 3 months ago I don't trust Dr.Sinclair at all. He is a researcher drinking Coke , soft drinks all day long saying it's o.k. because the ones he's drinking is NO SUGAR but artificial sweeteners. Also he's drinking alcohol especially wine talking about it's o.k. because it's resrevitol 😂😂😂😂 He is clown with big marketing. Reply @erdnadre7566 @erdnadre7566 3 months ago The biggest flipfloper ever Reply @michaelely3700 @michaelely3700 3 months ago F NMN Reply @bejusu @bejusu 3 months ago King Liar! Reply @michaelransom5841 @michaelransom5841 3 months ago I do not understand why the your statements are directly contradicting the conclusions of the very studies you are referencing, or directly contradicting other studies and human clinical trials, and I also don't understand why you are cherry picking and leaving out studies like the following: Karol Mateusz Pencina and others, Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study, The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 8, August 2023, Pages 1968–1980. I am so confused by the conclusions drawn here.. The second paper you reference states quote "Insulin-stimulated glucose disposal, assessed by using the hyperinsulinemic-euglycemic clamp, and skeletal muscle insulin signaling (phosphorylation of AKT and mTOR) increased after NMN supplementation, but did not change after placebo treatment. NMN supplementation up-regulated the expression of platelet-derived growth factor receptor β and other genes related to muscle remodeling. These results demonstrate NMN increases muscle insulin sensitivity, insulin signaling and remodeling in women with prediabetes who are overweight or obese." And the section you point to claiming that NAD+ levels were not increased in muscles is taken out of context.. why would you choose to do that, what is your motivation here? the full quote: "Although muscle NAD+ and nicotinamide content did not change after 10 weeks of treatment in either group (Fig. 1, ​,EE and ​andF),F), muscle N-methyl-nicotinamide, methyl-2-pyridone-5-carboxamide, and N-methyl-4-pyridone-5-carboxamide increased after NMN but not placebo treatment (Fig. 1, ​,G,G, ​,H,H, and ​andI),I), suggesting NMN treatment increased muscle NAD+ turnover." The key sentence here: "suggesting NMN treatment increased muscle NAD+ turnover." In other words, yes, NAD+ levels went up but there was such a deficit and such a need for additional NAD+, that they only observed the metabolites. But those metabolites would not have increased if NAD+ production had not increased. The same is true for most of the papers you've referenced, your conclusions, and the conclusions of the authors stand in stark contrast. I'm just confused, I want to believe that you are a trustworthy source of information. But for whatever reason, you are distorting the conclusions of the papers you are referencing. I find it incomprehensible why you would so that... I really do want to know why? 2 Reply @user-bz3wn1zo7e @user-bz3wn1zo7e 2 months ago (edited) Thanks doc for dismantling the utter nonsense that we have been fed by Youtube health channels mostly run by non-medical doctors. They are just regurgitating rubbish picked up from each other. Reply @alans177 @alans177 3 months ago goodvibes Dr Brad Stanfield Reply @boossersgarage3239 @boossersgarage3239 2 months ago apples and oranges, the studies are misguided and so are you, IMO> .... Reply @RandomGuy-lu1en @RandomGuy-lu1en 3 months ago I tried it once and felt absolutly nothing Reply 2 replies @Tarheb @Tarheb 3 months ago another bad video. Nine Supplements With STRONG Evidence Of Benefit Dr Brad Stanfield 211K subscribers Join Subscribe 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 . 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 K Share Thanks Clip Save 91,708 views Oct 15, 2023 1 product Dr Brad Stanfield tagged products below. Learn more MicroVitamin: A Low-Dose MultiVitamin & Mineral $49.00 drstanfield.com/products/microvitamin?srsltid=AfmBOoqdeJEp8hUzxEmv2SVyNkyVRcTgPn1GChHlhA21dLTHZygwB-pjIL4 💊 My full supplement stack: https://drstanfield.com/pages/my-supp... 💊 MicroVitamin (multivitamin & mineral): https://drstanfield.com/products/micr... 💊 Supplements I use from Amazon: https://amzn.to/44oEGZz ✨15% Discount Code: BRAD ✨ • ProHealth: https://www.prohealth.com/collections... ✨10% Discount Code: BRAD ✨ • DoNotAge.org: https://donotage.org/products/ • Renue By Science: https://renuebyscience.com/?rfsn=5206... ✔️ Roadmap - how to look young & feel strong: https://drstanfield.com/pages/roadmap ✔️ Twitter: / bradstanfieldmd ✔️ Patreon: / bradstanfieldmd Here are the links to the research papers referenced in the video: https://jissn.biomedcentral.com/artic... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://academic.oup.com/nutritionrev... https://pubmed.ncbi.nlm.nih.gov/25921... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.uptodate.com/contents/pra... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/28426... https://jissn.biomedcentral.com/artic... https://pubmed.ncbi.nlm.nih.gov/21744... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://alz-journals.onlinelibrary.wi... https://www.science.org/doi/10.1126/s... https://pubmed.ncbi.nlm.nih.gov/17413... https://ods.od.nih.gov/factsheets/Ome... https://www.mayoclinicproceedings.org... https://www.cochrane.org/CD011472/VAS... https://pubmed.ncbi.nlm.nih.gov/36516... https://pubmed.ncbi.nlm.nih.gov/31859... https://pubmed.ncbi.nlm.nih.gov/33383... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/34933... https://pubmed.ncbi.nlm.nih.gov/24894... https://pubmed.ncbi.nlm.nih.gov/31715... https://pubmed.ncbi.nlm.nih.gov/33417... ttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402070 https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/12398... https://academic.oup.com/biomedgeront... If you like this video please smash the thumbs up button, it really helps with the Youtube algorithm :-) #Supplements #Health The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel. Transcript Follow along using the transcript. Show transcript Dr Brad Stanfield 211K subscribers Videos About Dr Brad Stanfield tagged products below. Learn more MicroVitamin: A Low-Dose MultiVitamin & Mineral $49.00 Achieve your recommended daily intakes of vitamins & minerals without mega-dosing. Blended with Hyaluronic Acid for glowing skin, and TMG for exercise performance. With over 75% of Americans taking dietary supplements, multivitamins have become a staple in our daily routines. But have you ever stopped to question whether your multivitamin is truly giving your body what it needs? Introducing MicroVitamin: A Thoughtfully Crafted Low-Dose Multivitamin. Most multivitamins on the market today contain excessively high doses of vitamins and minerals, which may lead to potential side effects and wasted resources. MicroVitamin is different. We’ve carefully crafted our formula based on scientific research to help you reach the optimal recommended daily intakes of essential nutrients (both vitamins and minerals) while promoting a balanced diet and healthy lifestyle. A Balanced Diet Comes First: MicroVitamin is designed to complement a healthy diet, not replace it. We believe that obtaining nutrients from a variety of whole foods is crucial for optimal health. MicroVitamin aims to fill the gaps and support your nutritional needs when your diet falls short, ensuring you maintain a well-rounded and balanced approach to your health. The MicroVitamin Difference: ️ Embrace Moderation: MicroVitamin is meticulously designed to deliver the perfect balance of vitamins, minerals, Trimethylglycine (TMG), and hyaluronic acid. This careful formulation avoids overloading your body and eliminates the risks associated with excessive supplementation. ️ Achieve Glowing Skin: Our unique blend includes hyaluronic acid 200mg, a powerful ingredient known to promote skin health and hydration, giving you a radiant complexion from the inside out. ️ Enhanced Performance: MicroVitamin doesn't just provide improved cognition through balanced nutrition, it also includes 750mg of Trimethylglycine (TMG). This compound has been shown to boost strength, power, and endurance when coupled with exercise. Additionally, TMG serves as a methyl-donor and helps lower homocysteine levels, providing an added health advantage. ️ Trust in Quality: Our commitment to excellence means that MicroVitamin is made with only the highest quality ingredients, rigorously tested for purity and potency, so you can have complete confidence in the product you’re using, which means peace of mind for you and your loved ones. Quality Assurance We’ve partnered with a USA supplement manufacturer called ‘Makers Nutrition’ to produce MicroVitamin. Their facilities are GMP audited and FDA registered, so you can be assured that MicroVitamin is meticulously produced and thoroughly tested for quality. SHOP Dr Brad Stanfield 447 Comments rongmaw lin Add a comment... @DrBradStanfield Pinned by Dr Brad Stanfield @DrBradStanfield 1 month ago Would you take the 10th supplement at the end of the video as well? 💪 Roadmap - How to look young and feel strong: https://drstanfield.com/pages/roadmap 💊 MicroVitamin (multivitamin & mineral): https://drstanfield.com/products/microvitamin 💪Join Patreon for early access to my videos & Discord chat: https://www.patreon.com/bradstanfieldmd 13 Reply 16 replies @ruskino9499 @ruskino9499 1 month ago 1. Creatine 2. Protein powder 3. TMG 4. Multivitamin 5. Omega 3 6. Psyllium husk 7. Collagen peptides 8. Hyaluronic acid 9. Low dose melatonin 425 Dr Brad Stanfield Reply Dr Brad Stanfield · 32 replies @123ChrisG @123ChrisG 1 month ago 1. 0:02 Creatine 2. 1:55 Protein powder 3. 3:59 TMG 4. 5:29 Multivitamin 5. 6:41 Omega 3 6. 8:06 Psyllium husk 7. 8:32 Collagen Peptides 8. 10:04 Hyaluronic acid 9. 10:53 Low dose melatonin 10. 12:46 NAC 144 Reply 1 reply @terfalicious @terfalicious 1 month ago I appreciate your dedication to objective presentation of available facts. I wish more people would realize how much time and effort such research takes - kudos to you for your humanitarian task! 24 Dr Brad Stanfield Reply @UghIHateTheseThings @UghIHateTheseThings 1 month ago Man, I love this channel so freaking much. I remember coming across it back when you had 7K followers way back in the day. Amazing to see the channels progress and rightfully so with how unbiased you always make an effort to be, as well as keeping in mind the common questions people have and answering them preemptively. So grateful for all your hard work, you’re truly changing lives for the better. 12 Dr Brad Stanfield Reply Dr Brad Stanfield · 2 replies @jonathanantoine4962 @jonathanantoine4962 1 month ago We need more curators with high standards in this world, thank you for your work 4 Dr Brad Stanfield Reply @stefanbucher9054 @stefanbucher9054 1 month ago Dr. Stanfield, thanks for your dedication to public health with your videos. I have changed my vitamin supplementation because of your scientific summary of the evidence. Quick question: I have never heard you commenting about MCT (medium chain triglycerides). A few years ago they were all the rage on memory improvement and the like. Would you, please, add your comments about it in a future video? As if you needed more work :-). Thanks in advance 9 Reply @vladimir-qx9sd @vladimir-qx9sd 1 month ago Dr Stanfield, I've been hearing a lot about ergothioneine lately. Do you think it's still too early to recommend and if getting it through supplements makes sense? In general, it's also confusing whether it's better to supplement with food extracts or isolated nutrients (e.g., mushroom extract vs. ergothioneine supplement). 3 Reply @willthornton5379 @willthornton5379 1 month ago Something to keep in mind regarding Hyloronic Acid. It raised my blood pressure. My blood pressure was always normal, when I was taking Hyloronic acid, my blood pressure increased by 20 points. It took 2 months of not taking it, now my blood pressure is the lowest it has ever been, thanks to my supplement regimine. This doesn't happen to all people, but you should make sure your blood pressure isn't too high if taking it. Thanks :(. I also took Hyloronic acid from DoNotAge, so it was high molecular weight and of great quality. 2 Reply @bird.passion @bird.passion 1 month ago (edited) Thank you, I enjoy your videos! I'm still unsure about protein intake. My kidney doctor told me to eat a low protein diet to protect my kidney. I have only one kidney (it's healthy). I noticed that you dismissed the mouse studies on protein but not on magnesium taurate so I'm confused but I enjoyed the video. 7 Reply @hajagosb @hajagosb 1 month ago I really appreciate these videos. I've started following your advice more than a year ago. A half year ago my blood test was fine, but now it has showed that my creatine levels are too high. Why do you think it is happening? Should I stop supplementing completely? Is this a sign of something else? 1 Reply @samc821 @samc821 1 month ago Great list, I take alot of these supplements and they've changed my health for the better, NAC was a game changer for me in terms of breathing during exercise, creatine has been great for overall constant energy levels during the day with no stimulant like crash, TMG has been good for muscle energy and pump. 1 Reply @ChanchoFrog @ChanchoFrog 1 month ago Hi Dr. Stanfield, I've been following your video for years, and really appreciate them, and i take many of the same supplements that you do. Re: Hyaluronic Acid, I take that as well, but I do get concerned sometimes about all the potential cancer risk stories that you point out. For example, most of the literature I've found seems to indicate that High Molecular Weight HA trends toward anti-cancer effects, and Low Molecular Weight HA trends toward promoting cancer. But if even if High Molecular Weight HA is broken down in the digestive tract into Low Molecular Weight HA, then are we putting ourselves at some risk for potential cancers? The mice study you mention is encouraging, but I was just wondering if you've seen any other good studies proving that oral supplementation of HA is safe? Thanks again for all the info! 3 Reply @rewtoho6071 @rewtoho6071 1 month ago I'm getting lost what's right when it comes to protein intake. “Psyllium husk” has long been known in Japan as “OOBAKO”. I was able to learn about the effects of "OOBAKO" once again. Thank you. 4 Reply @paulelkins425 @paulelkins425 1 month ago Great video running down the most promising supplements based on data. I was surprised not to see Taurine make the list considering the recent data on its longevity benefits. Also, I'm interested in your thoughts on ergothioneine's benefits. 1 Reply 2 replies @MrStarchild3001 @MrStarchild3001 1 month ago The reason my 71 yr old stopped supplementing with creatine is because of this summary article called "The two sides of creatine in cancer". I highly recommend checking it out and commenting on it. 4 Reply 3 replies @ivanandreevich8568 @ivanandreevich8568 1 month ago I lowered my cholesterol by 25% and I largely attributed to psyllium husk daily. Also added vitamin B3 as well as more choline. I was already living a pretty good lifestyle and exercising every day. It's just genetic for me to have higher cholesterol. 8 Dr Brad Stanfield Reply Dr Brad Stanfield · 8 replies @soullessvacuum @soullessvacuum 1 month ago I can't wait for you to do a deep dive into TAURINE supplementation. There are not many studies out yet but those that emerged recently are very, very promising. 2 Reply @joshuaharich7384 @joshuaharich7384 1 month ago I have a big concern on melatonin regarding it’s function as a hormone. We need more studies on this, I’m so thrilled to see updates in this area! Love your content 10 Reply 6 replies @antraxuran9 @antraxuran9 1 month ago It would be very interesting to see an episode on the role of BCAA in longevity, there seems to be a lot of controversy around the topic :) 4 Reply 1 reply @Tom-vh6jx @Tom-vh6jx 1 month ago Hi Dr Stanfield, thanks for the great videos. I tried your Psyllium Husk Powder brand for two months and was underwhelmed with the results (stool softener-only, added to bloat). Have you tried ORGANIC INDIA Psyllium Husk Pre & Probiotic Fiber? It immediately regulated my bowels and reduced bloat. Thought I'd share that suggestion. Thanks Reply @scifreak7152 @scifreak7152 1 month ago Thanks for these suggestions! Love your videos! Like one of the other commenters, I do waver re: hyaluronic acid. It clearly has benefits for skin so I currently take it. But could you please point out any other studies besides that mice study that indicate oral hyaluronic acid doesn't potentially cause cancer? There's so much online saying otherwise that many of us who want to take care of our skin just want peace of mind. Reply @MrBeckala @MrBeckala 1 month ago my wife & I have been taking these supplements for about 2 years...I think they work for us...we walk 10 to 12 miles a day & i doubt we could have done that 30 years ago. Reply @venator111 @venator111 1 month ago Thank you for your work! Its appreciated (from one doctor to another 😊) 1 Dr Brad Stanfield Reply @haraldgimsejr1503 @haraldgimsejr1503 1 month ago (edited) Creatine actually gave me vertigo, never had any problems with it until a month of using creatine, i stopped creatine and in 2 days ive never had it again. And yes, i drank enough water Reply @gordonwho @gordonwho 1 month ago Thank you for your great work Dr! Do you consider glucomannan equivalent to psyllium husk? Reply @digitaldonotage2605 @digitaldonotage2605 1 month ago Thanks for a great breakdown as always Dr Brad! Reply @michelem226 @michelem226 1 month ago I had muscle cramps when I started creatine, but those went away. Now I'm having heart palpitations, so I think I'll go off the creatine and see if that helps. I honestly do think I'm an unusual person that is sensitive to creatine. Reply 1 reply @vetsai8199 @vetsai8199 1 month ago The only supplement on your list of ten that I don’t take is low dose melatonin. I any dose size, it causes my to have night terrors, so that is off the table! After five years of different collagen peptides, I temporarily stopped them due to no effect on my skin, hair or joints. I have recently restarted a collagen peptide made from eggshell membrane. I’ll stop that one if I don’t see any results after one year, since this one is more expensive than the other three. 1 Reply @user-et9ne1hm7d @user-et9ne1hm7d 2 weeks ago Great research!! We need more critical thinking people like you filtering all the mess circulating in open media and internet with no regulation at all Reply @shar7508 @shar7508 1 month ago Is your mineral supplement complete for osteoporosis? Thank you very much 😊 2 Reply @andrewandreas5795 @andrewandreas5795 1 month ago Really nice video! Could you please make one focused on supplements for men? Perhaps including your opinions about things like tongkat ali, shilajit, ashgwaganda etc. 3 Reply @stargazerbird @stargazerbird 1 month ago Soy definitely had an effect on my hormones when I ate a lot of soy protein powder. Seems people report a side effect and then the manufacturers do studies to ‘prove’ they don’t happen. Reply @spiffffffffff @spiffffffffff 1 month ago You might also look into the research on hyaluronic acid and the other "joint supplements" role in maintaining the endothelial glycocalyx in the interest of reducing atherogenesis. 1 Reply @M.C.Blackwell @M.C.Blackwell 1 month ago Excellent research and information, as always! Thank you! 1 Dr Brad Stanfield Reply @MegaSantiago20 @MegaSantiago20 1 month ago Thanks for these videos and their detail. Please keep it up🙏🏼🌱 Dr Brad Stanfield Reply @lynnfrench8983 @lynnfrench8983 1 month ago You had mentioned high dose IV vitamin C had caused deaths in hospitals. It is malpractice and liable not to first check kidney function and co morbidity caveats. We use this in our clinics for some cancer patients with positive outcomes. Usually followed with ALA, Glutathione, buffers, and or subcutaneous mistletoe. Reply @chucklohn522 @chucklohn522 10 days ago I was not a big fan of your NMN research before, but you are starting to win me over now. Can you do a video on NAD+ injections? I see them advertised a lot here in Bangkok. And could you discuss Liposomal NMN, NR, etc? Some claim that the uptake is higher when it is in a liposomal or time release form. Thanks. Reply @stargazerbird @stargazerbird 1 month ago Ah that must be why my gout flared. I started Creatine a few days ago. I wondered what I had been eating to cause it. Frankly I come here to find out what side effects to expect from supplements especially, it seems, the ones you tell us are non existent. I tolerate a multi and HA. As for the rest, collagen makes me sleepy and gives me headaches, NAC horrible constipation, D3 upset my stomach in the opposite direction. I sleep just fine without melatonin. Have to be careful with magnesium or it can keep me sleepy. Never tried TMG. I eat Salmon and other oily fish several times a week and limit junk foods so I don’t need omega 3. Seems to me that supplement benefits are very dependent on where your body is at and taking them based on trials is not a good idea. Self experiment by all means but monitor how they actually make you feel. Based on that I might go back to NMN. Made me feel good. 1 Reply 1 reply @markyoung6801 @markyoung6801 1 month ago Dr Brad. Could you comment on the benefits of Nutritional yeast? Specifically relating to a Ketogenic diet. Reply @NO_obs @NO_obs 1 month ago Hi Brad regarding nac / glycine do you know if magnesium glycinate counts as glycine intake or would it only count as magnesium? this seems a lot more common than standalone glycine and also contains magnesium so you may be getting both supplements in one go 1 Reply 1 reply @graciandaniele @graciandaniele 1 month ago I can’t stop watching your vids…so much quality, super valuable info! I love this channel… A giant thank you from Italy ✌️ Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply @ArticBlueFox96 @ArticBlueFox96 1 month ago I would love for Dr. Brad Stanfield to do a video on supplements for mental health and mood issues, such as: depression, low mood, mental stress, anxiety, intrusive thoughts, obsessions, empathy burn out, anhedonia, etc... For example I take L-Theanine and Taurine for their GABAergic effects. Reply @Barb6106 @Barb6106 1 month ago Another great video with helpful information. Thank you! I really enjoy this channel 3 Reply @Funsoul8 @Funsoul8 1 month ago Yes but also you must make sure the Hylauronic Acid you take comes from Rooster combs, or it doesn’t work. Also I stopped NAC because it lowered my blood pressure too much while I already have low BP.. Reply @jiashuliu9067 @jiashuliu9067 1 month ago (edited) Hi Dr Stanfield speaking of soy I wonder what’s ur opinion on the argument that soy intake should be limited to avoid rising igf1 and therefore speeding up aging? Thanks 1 Reply @ainakunigelyte @ainakunigelyte 2 weeks ago Doctor, could you please advice on a supplement that helps both density - probably a mix of magnesium with vitamin k? Lots of us loose bone when aging and that also affects face aging a lot - undereye hollows become bigger, jawline becomes smaller, and not retinol can help that. Please advice! :) Reply @ricardorodriguesrr18 @ricardorodriguesrr18 1 month ago Looking at your list of supplements i was wondering why you take zinc without copper since zinc deplets the levels of copper. Reply @jonathanantoine4962 @jonathanantoine4962 1 month ago Regarding protein, wouldn't it be better to consume a mix of plants proteins to avoid high methionin consumption? Reply @mmalameh @mmalameh 1 month ago Prior video(s) you recommended 1.4-1.6 g of protein per kg. And you mentioned there are no benefits observed above this range. 4 Reply @TheOfficialBullyMaguire @TheOfficialBullyMaguire 1 month ago NAC seems to boost how deep and well i sleep when i take it with my night-time magnesium. Ive nitced a significant difference when pairing them together and when only taking magnesium 3 Reply 5 replies @HeartFeltGesture @HeartFeltGesture 1 month ago I have heard its not a good idea to take direct-route Melatonin. It is suggested it is better to take the amino precursors, namely L-Tryptophan, or 5-htp. If 5-htp is chosen, it should be understood that this is not a long term protocol, 5-htp is a strong drug and has a pronounced effect on Serotonin levels, if Serotonin levels remain high for too long, the receptors will down-regulate (die off) and this has negative effects for mood and well-being. If 5-htp is used, it must also be in tandem with amino precursor L-Tyrosine, the reason being that if you increase Serotonin, you also simultaneously drive down dopamine. SSRI's dont work this way, they dont increase Serotonin, they make what Serotonin you naturally have last longer in the blood. L-Tryptophan can be used long term at around 1-2g per day, taken in the evening on an empty stomach. The ratio for L-Tyrosine and 5-htp supplementation is 10:1, that is 1 gram of L-tyrosine to every 100mg 5-htp. Supplementation of these two powerful neurotransmitter should only be for a period of around 3 months. After a break of 3 months, another course can be taken if needed. 1 Reply @MegaVictorygirl @MegaVictorygirl 1 month ago I love Dr. Stanfield’s videos. My blood pressure had been high for many years and I took medicine until the carnivore diet dramatically lowered it. Now I have high LDL cholesterol. I hope Dr. S will do a video on this. Thank you! 2 Reply 2 replies @michael-qp9xd @michael-qp9xd 1 month ago Hello doctor - on your general recommendation for creatine - any research would have on effect on blood levels of homocysteine for say those with one bad copy of mthfr gene and homocysteine greater than 10 and wanting to lower to under 7. Or does supplementation increase levels of BUN? Thanks on any research can find on this. Reply @shar7508 @shar7508 1 month ago Dr. Brad, would a person with osteoporosis need more minerals than micro minerals? Reply @lreynolds1002 @lreynolds1002 1 month ago What about glycine ? What’s the difference in TMG and just regular glycine ? I take normal glycine along with NAC. should I replace glycine with TMG or are they totally different ? 1 Reply @petervafeades4095 @petervafeades4095 1 month ago Would you consider flaxseed as an alternative for psylium? Reply @chuckpalahniuk2174 @chuckpalahniuk2174 1 month ago love your vids ! can't wait to try your vitamins 1 Reply @jerrrdy @jerrrdy 1 month ago Could you make a video on the best way/times to take these supplements? Could I just mix everything at once and just drink it? 1 Reply @beausalts2701 @beausalts2701 1 month ago Regarding fish oil - I find that it lowers my triglycerides. However, I have high LDL but am otherwise healthy - could fish oil be the cause of high LDL? Insofar as creatine, I find it helps me workout harder in the weight room. However, can creatine elevate serum creatinine levels? Reply @RC-ud4qo @RC-ud4qo 1 month ago Love your informative videos 🙏 thank you Dr Brad Stanfield Reply @miked319 @miked319 1 month ago When and how to take these supplements, morning, evening, with or without food? Which ones can you take together? Thanks 1 Reply @stevebelzer4758 @stevebelzer4758 1 month ago According to David Minkoff MD - bioavailability of exogenous protein is about 40% per gram However Perfect AMINO has a laboratory assay bioavailability of 99% Therefore 10 per gram tablets of perfect amino equals = 100 grams of protein consumed Also Leucine in blood serum new clinical data shows exogenous leucine amplifies biology of molecules of NMN Resveratrol and Berberine in a “clinically significant “ result ❤ 1 Reply @mathewillimoottil1833 @mathewillimoottil1833 1 month ago Would you recommend casein protein powder given that it takes longer to digest? Reply @adriananatasha9486 @adriananatasha9486 1 month ago How about how to take them - when in the day/ with food OR no food / do they interact with each other OR other supplements (eg spirulina, Vit C, Biotin)? Thank you! :-) Reply @Alexa-vo4kk @Alexa-vo4kk 1 month ago Any tips for taking TMG? I can't seem to take it without suffering from insomnia Reply @will80533 @will80533 1 month ago Dr. Stanfield, after reading some of the comments below, maybe a listing of the top 100 supplements sold, with a grading of each. I very much appreciate effort and insight. Reply @baileystruss7319 @baileystruss7319 1 month ago (edited) So whats the verdict for Glynac and taurine? Lots of buzz out there about these. Also HMB shows benefit in maintaining muscle mass even in the inactive (i have me/cfs). Also some buzz about HMB in dementia and cognitive. 2 Reply @mandarp9472 @mandarp9472 4 weeks ago Vitamin D 3 and Vitamin K 2 MK 7 should also be added to the list. Reply @HakuCell @HakuCell 1 month ago (edited) you said you take 1-2 capsules of fish oil per day, so how many capsules of algae oil should i take per day? i ask this because algae oil seems to have much less epa than fish oil, meanwhile the dha content per capsule seems to be the same. 1 Reply @andreasstamatakis4983 @andreasstamatakis4983 1 month ago I’ve never seen any videos on your channel comparing Broccoli sprouts to GlyNac for Glutathione production. It would be an interesting comparison. 🤔 1 Reply @ballapalleballe @ballapalleballe 1 month ago Well done Brad, thanks. Reply @seppimweb5925 @seppimweb5925 1 month ago I have read that betaine (TMG) has many health benefits, but I have also learned that it can be dangerous if you take too much or too often. Betaine can promote the formation of TMAO in the body, if you have certain gut bacteria that make TMA from choline or carnitine. TMAO is a molecule that hardens the arteries and increases the risk of heart attack and stroke . Therefore, you should use betaine only in moderation and under medical supervision, especially if you eat a lot of meat or fish. I would also recommend doing a urine test to see how high the TMAO level is, before you supplement with betaine. That is my opinion, but everyone should decide for themselves what is best for them. What do you think about it? 2 Reply @fatnutsface5437 @fatnutsface5437 1 month ago My muscles and energy respond really well to creatine but it ruins my sleep for some reason. Any ideas? Reply @richardriemer8859 @richardriemer8859 1 month ago I like your style and trustworthy advice as it is data-driven. There is a ton of misinformation, disinformation, and mal-information out in YouTube Land. I have examined some of these soi-disant miracle diets and have taken what works and left the rest behind (trial and error). As a runner, my most important lesson learned is reducing carbs as much as possible (contrary to a lot of 'advice'). I've found them to be inflammatory, or at least at the levels prior to my reduction. After a long run, I'm no longer sore for three days. I started carnivore (which worked great for a short time), moved more towards keto, and am now leaning toward a Mediterranean diet. I just need to find a sustainable balance but am also concerned about my saturated fat intake. I am trying to get my protein levels up but it's hard to do. I have just recently gone through creatine loading. Based on your advice I am very wary about taking too much r-ALA, but it seems to help my recovery post-racing. How does one know if your oxidant/anti-oxidant levels are in check? Is carb loading for running a race just hype? I seem to run fine while in ketosis. Thank you. 2 Reply @kokofitfaded @kokofitfaded 6 days ago Thanks for the upload! We appreciate your work. Dr Brad Stanfield Reply @mathewillimoottil1833 @mathewillimoottil1833 1 month ago Which brand do you use for your Omega-3 supplements? Reply @christhomas484 @christhomas484 1 month ago Dr stanfield, are you aware of the dangers of pyridoxine hcl which you use in your multi vitamin. multiple cazse studies implicate it as damging the uptake pathway and blocking actual b6 uptake , some case studies showed extreme damage to the subjects. my dad was taking it in large regular doses for ms and the problms aligned completley with his usage and basically went away when he gave up his healthspan b vitamins Reply @MiguelCorreiaDaCunha @MiguelCorreiaDaCunha 1 month ago Dr. Brad, please talk about creatine and bipolar disorder! Reply @californiadoll6273 @californiadoll6273 1 month ago Straight to the point, that's why we love you ❤. 1 Reply @KingRockets @KingRockets 1 month ago Doc, can you please consider making a video on Ergothioneine? 2 Reply @nicosmind3 @nicosmind3 1 month ago In the past I've struggled with finding a supplier of TMG in the UK and Spain. Does anyone know of a good source/seller? In the past I've only been able to find it as part of a product with many different things in it. And not TMG alone Reply @alanc6468 @alanc6468 1 month ago Comments have been too harsh in recent videos. This guy is breaking down thousands of papers in a digestible manner. Your concerns over Vitamin D3 intake are valid but saying he is shilling his Multivitamin doesn't invalidate the evidence he is referencing! 187 Reply Dr Brad Stanfield · 19 replies @chrisfranco6603 @chrisfranco6603 1 month ago Took a 500 mg TMG pill this morning. Gave me a light headache for about an hour. Reply @thereignofthezero225 @thereignofthezero225 1 month ago "Creatine causes no risks to our kidneys...." Only true if your kidneys arent already impaired. Many peoples are, including mine (and a lot of them probably dont know it) 1 Reply @petermatus3385 @petermatus3385 2 weeks ago Could you please cover msm, glutamine and glycine? Reply @whiteninja9481 @whiteninja9481 1 month ago The supplements are not the controversy. Dr. Robot is the controversy. 3 Reply @lilascharmante2712 @lilascharmante2712 1 month ago (edited) Tmg helps my wrists so much, I take it just for that, didn't know it could help with exercise Reply @grugnotice7746 @grugnotice7746 1 month ago NAC is a must if you drink alcohol. Greatly reduces the severity of a hangover. Reply @zzmarx @zzmarx 1 month ago "But it's important to remember that we are not mice living in a controlled lab." ... thanks, for that reminder, I was beginning to wonder. 😁 1 Reply @aruncivileng1212 @aruncivileng1212 1 month ago Your videos are very interesting and informative, I am form india, will it fit to us? Is your recommendation to all around the world? Reply @skyltdockan @skyltdockan 1 month ago 03:08 Better to not mix bananas with berries since it "blocks" the bioavailability of all the good flavan-3-ols. Source study: Impact of polyphenol oxidase on the bioavailability of flavan-3-ols in fruit smoothies: a controlled, single blinded, cross-over study 5 Reply 2 replies @edgarsnake2857 @edgarsnake2857 1 month ago Thanks for the great overview. Dr Brad Stanfield Reply @christ4814 @christ4814 1 month ago Creatine DOES negatively impact mood in some people. Irritability and aggression. Similar to roid rage, but at a lower level. 1 Reply @guillermofuentes151 @guillermofuentes151 1 month ago Hey Brad, any alternative you would reccomend for Psyllium Husk? I've tried to consume it with either water or on oatmeal but I just dislike texture of it once mixed with water. 1 Reply 4 replies @0113L @0113L 1 month ago Does Creatine cause Cancer and what are your thoughts on Methylene blue? Reply @Vedicarts108 @Vedicarts108 1 month ago I watch all your videos, thank you Doc. Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply @debbiebridges6350 @debbiebridges6350 1 month ago Will creatine still help if you do not exercise for someone that is 70? Reply @johngoh767 @johngoh767 1 month ago Dr. Brad, do you have a TRANSCRIPT of this talk? Much appreciate if you can provide a link for it. Reply @scottk1525 @scottk1525 1 month ago Thanks, Brad! Couple questions: 1) Has protein powder been shown in any studies to be effective? Protein in its natural form is fleshy, wet, mushy, organic meat (or plants.) Naturally I'm skeptical that my body is going to recognize and utilize this dried, extracted, concentrated, preserved, cooked, bleached, flavored, chemically altered pile of sand as the same substance. Are there any studies supporting the use of protein powder? 2) Dr Steven Gundry (among others) argues that the reason our protein requirements are so high these days is that the microbiome in our guts, and the linings of our gut walls are so jacked up (on account of all the garbage we eat,) that we need to compensate for lack of absorption with excess intake. He also claims that with optimal gut health and absorption capacity, one can thrive on less than 50g of protein per day, even as low as 25-30 grams. Any thoughts on that? Reply 1 reply @balitzky @balitzky 1 month ago (edited) Does somebody know some studies about high dose melatonine, like 5-30 mg or more? There are some biohackers who use this high range dose due to its antioxidant potencial Reply @pjaworek6793 @pjaworek6793 1 month ago (edited) #2 is already off topic since protein is extremely easy to obtain without "supplements". A "multivitamin" is also not a "supplement" with proven benefits. Individual vitamins are. Lastly melatonin might ruin your sleep quality if you have histamine problems. It does not improve sleep quality if your circadian rhythm and latency are ok already. Reply @DavidPaulNewtonScott @DavidPaulNewtonScott 1 month ago If you are getting your omega 3 normally then fine, but just take it as an insurance policy. Reply @emergentform1188 @emergentform1188 1 month ago Brilliant, love it, thanks Dr. S! Dr Brad Stanfield Reply @MichaelEdwardWright1 @MichaelEdwardWright1 1 month ago I take 180 mg melatonin per day based on Dr Schalenberger’s lectures and his reference to 5000 scholarly articles regarding melatonin. Reply @mark-ge8dr @mark-ge8dr 1 month ago If you are retaining muscle weight or can gain muscle with weight training then maybe that implies you don’t need additional protein supplements. If losing muscle weight it would make sense to boost your protein intake but it seems to me older people lose muscle weight to a large extent from being sedentary. There are plenty examples of older people with incredible musculature from weight training. Trying to gauge your protein intake and aiming for 1.6 g/KG doesn’t strike me as being reliable outside of a controlled study. Get a wide ranging blood analysis every five years and it will show your serum protein levels. That’s my common sense attitude to protein at least 😅 1 Reply @roberts.1400 @roberts.1400 1 month ago In Europe, fish oil pills must now list that atrial fibrillation is a common side effect of taking fish oil supplements, this is according to the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency (Medscape, October 13, 2023). So, it looks like it's better to eat sardines, anchovies, wild caught salmon along with a plant based diet to get your Omega 3's. Reply @davidhauk4163 @davidhauk4163 1 month ago Great vid. I see people are making out their shopping lists. Me too. Reply @BrianSladek @BrianSladek 3 weeks ago Please make sure you tell people to get their blood tested first before recommending things like this. I love your content, just some feedback. In my case I only eat 2 cups of chicken a day or so and my creatine levels were already quite high when I had my blood work done. I am 39 years old. I think the body may store some of it, not sure or genetics. I did try taking it when I was in my 20’s but caused some hair thinning for me so I quit (my personal experience) Reply @miiitchhh225 @miiitchhh225 1 month ago (edited) Dr. Brad I preordered your supplement back in September, any update on when is it shipping? 2 Reply Dr Brad Stanfield · 2 replies @jondel3304 @jondel3304 1 month ago Which magnesium is he recommending? Reply @AlBool @AlBool 1 month ago Great video! Can I add the Collagen to my Whey protein or is I better to take them separately? Reply 3 replies @aldilee51 @aldilee51 1 month ago What is your opinion on methyline blue? Reply @brucejohnston362 @brucejohnston362 1 month ago Hi Brad, when are you going to be able to ship your multivits to your fellow kiwis? Reply @Resolutelt @Resolutelt 1 month ago I found that taking 1mg of melatonin sublingually induces sleep in about 15 minutes. Reply @ramji7zs781 @ramji7zs781 4 weeks ago Can you please make a video on best anti aging supplements ? Will Ca AKG works for anti aging ? And can u please make a video on Bryan Johnson supplements ? Reply @mickmiah7605 @mickmiah7605 1 month ago Cheers Brad. Great List Ty. Dr Brad Stanfield Reply @susymay7831 @susymay7831 1 month ago Timestamps would help your nice videos ❤❤❤❤❤ 6 Reply @gordangrebovic4128 @gordangrebovic4128 1 month ago Everybody knows Bryan Johnson. He is a vegan. He does naturally eat some proteins as part of his plant based diet. But does he eat a lot of proteins as hier suggested? No, not at all! And does he have a super strong muscles and a low body fat? Yes! You can check out his latest strength test results and his body fat percentage if you are interested. It's a myth that people in the western world are deficient of proteins. The real issue is that the average caloric intake in the USA is 3540 kcal/day. A significant part of this surplus of calories are proteins. And the average daily physical activity is less than 20 min. So it's very simple: less calories (if you are overweight), more physical activity! Eat whole food and no need to worry about proteins. 2 Reply @rumblestein7651 @rumblestein7651 3 weeks ago I thought you said in previous posts that you take NAC with glycine?? Yet on this video you left out glycine? 1 Reply @whatthefunction9140 @whatthefunction9140 1 month ago I agree with everything except the melatonin. As our bodies will just adjust its natural levels over time. Reply @NotMolly-jf2rh @NotMolly-jf2rh 1 month ago Kg per kilo of current weight or optimal? Reply @franktimestamp @franktimestamp 3 weeks ago NAC is for liver detox, which for myself is an occasional thing... Reply @specialagentzeus @specialagentzeus 1 month ago You should come up with a single pill that contains these supplements call it GODMODE Reply @captainnoyaux @captainnoyaux 1 month ago I couldn't find info on psyllium husk, should one take it with vitamins ? or when ? Reply @Ferch @Ferch 1 month ago But Dr Stanfield, you said in another video "Melatonin supplements should be avoided due to lack of evidence and potential LONG-TERM HEALTH CONSEQUENCES." 1 Reply 1 reply @nvn9196 @nvn9196 1 month ago Does anyone who eats large amounts of fiber through vegetables and other foods still need to take psyllium husk? Reply @Tts657 @Tts657 1 month ago How about creatine and asthma? Reply @ytsux9259 @ytsux9259 1 month ago (edited) Magnesium (several forms) also works great. And so many other supplements work too, not just those 9. 1 Reply @jasonchu852 @jasonchu852 1 month ago Some people say collagen peptides may cause cancer. Is there any human data showing that the long term consumption of collagen peptides is safe? Reply @Purewalite @Purewalite 1 month ago All fish and krill oils tend to upset my stomach. I use flax in my shakes but would like another option. Reply 2 replies @johngoh767 @johngoh767 1 month ago Don't use calcium, zinc, or magnesium supplements at the same time? Reply @RapidFireAU @RapidFireAU 1 month ago Could you please do a video on HMB. Please! Reply @stevenw4549 @stevenw4549 1 month ago I've read that protein powders are the worst for your kidneys. You have any studies on that? Reply 1 reply @snshahid4710 @snshahid4710 1 month ago Good information 👍 Reply @allehelgen @allehelgen 3 weeks ago Creatine and protein powder have badly increased my serum creatinine, above considered safe levels. I've tested cystatin C and values were in the normal range. I'm not sure if it is a good idea for me to take these supplements again. 1 Reply 1 reply @jment34 @jment34 1 month ago (edited) Excellent info by the way at 2:40 1 kilogram is 1000 grams 160 grams of protein isn't that much. Reply @Adel3625 @Adel3625 1 month ago As soon as a doctor starts selling something, it poses a serious problem, it raises a red flag! 3 Reply @michael-qp9xd @michael-qp9xd 3 weeks ago Hi - great your vitamin supplement reformulated with closer to RDA amounts now. Have too the natural forms of folate and b12. But then have synthetic form of b6 - why used this form. I have the mthfr mutation and need natural version. Would consider maybe change in future? Synthetic Vitamin B6 – Pyridoxine hydrochloride comes from petroleum ester, hydrochloric acid, and formaldehyde. It isn’t readily absorbed or converted and has been shown to actually inhibit the action of natural B6 in the body. It also has side effects not normally found with natural food sources of this vitamin. Reply @RealJoshBinder @RealJoshBinder 1 month ago So you take protein powder ignoring mice studies but take magnesium taurate because of mice studies 🤔 7 Reply 1 reply @nahidbodiz7053 @nahidbodiz7053 1 month ago For people with no excersize , is creatine still beneficial? Or dangerous? 1 Reply 2 replies @ronin341 @ronin341 1 month ago I cant take creatine cause I have a chronic lung condition and it makes it worst. When I start taking it after few weeks I start to get shortness of breath and wake up at night trying to catch my breath. When I stop take creatine the shortness of breath goes away. Too bad cause creatine really works, for the time that I take it I have good results with it. Reply 2 replies @lawlewful @lawlewful 1 month ago can we have a chapter about soy protein? Reply @jontpt @jontpt 1 month ago No one seems to address the possible carcinogenic effect of NAC. There are several recent studies which indicate that it may exacerbate lung and skin tumors... 1 Reply 1 reply @richardanderson7669 @richardanderson7669 1 month ago When you tell us how much to take for a certain body weight could you please include pounds for us Americans. Thank you. Reply @SilhSe @SilhSe 1 month ago Back then I thought TMG was a fad. 😅 Reply @Schu2505 @Schu2505 1 month ago It’s not worth it in my opinion, especially as you get older. CKD is tough and creatine doesn’t help in this respect. Reply @nishchal11a @nishchal11a 1 month ago What about COQ10 ? 1 Reply @zoomankat @zoomankat 4 weeks ago I reckon if You gave Brad a shake he would rattle! Reply @stargazerbird @stargazerbird 1 month ago Extra fibre only works for those with peaceful guts. For IBS etc it can be a disaster. Reply @MichaelEdwardWright1 @MichaelEdwardWright1 1 month ago Have you seen the study demonstrating that 7 grams glycine and 9 grams N-acetylene cysteine per day raises NAD levels in old people to close to youthful levels? Reply 2 replies @GeezerTuber @GeezerTuber 1 month ago I thought there was some concern than melatonin can reduce adaptation to exercise and affect sex hormone levels. Is that incorrect or has there been further study? Reply 1 reply @leonaowen9234 @leonaowen9234 1 month ago What about INUNLIN powder? Reply @kevinmccarty6759 @kevinmccarty6759 1 month ago (edited) You said that the production of melatonin is 10-80 mcg “per hour” but the report you showed says “per night”. Which is correct - 80 or 640? Big difference. Reply 1 reply @liveloveride1676 @liveloveride1676 1 month ago Good content this time. Reply @limeanrepid5751 @limeanrepid5751 1 month ago (edited) Regarding omega-3’s specifically from fish oil , there has been much controversy. Specifically, a class action lawsuit states that during production, the high heat used cleaves the glycerol bonds and that effectively you have a product that contains NO omega-3 and effectively a compound that does not exist in nature. I don’t know how true this is or if there is any merit to it. However, it does raise an important issue of concern. Given that fish oil is a multi billion dollar industry, can we trust all manufacturers? My question is this ….. can I get enough omega-3 fish oil from a can of sardines or kippers etc. I would much prefer a more natural and minimally processed product. 😊 By the way, this class action lawsuit implicates many reputable brands, including the one I had been taking. Sorry to say but I don’t have much faith in most supplement companies. Reply @angelamorris4304 @angelamorris4304 3 weeks ago Psylium Husk causes me constipation, Collagen and hylauranic acid makes me dizzy/vertigo. Soy affects my Thyroid, and Creatine makes me feel like I'm gonna lose my mind. I can take Carnitine, with no problems. I have to be careful of supplements. It's probably due to my mental condition(Anxiety/Panic Attacks). I had a trauma to my brain about23 years ago, so thats probably the problem. Reply @justinthompson5631 @justinthompson5631 1 month ago You can't make a video every week of "The only supplements that ACTUALLY work." 4 Reply 1 reply @wocket42 @wocket42 1 month ago All the Gly-NAC you need you can get from real food like red meat and bone broth. Why would you add small amounts like 1g with supplements? Reply @Jeybes @Jeybes 4 weeks ago What kind of supplements brand will you suggest to buy in New Zealand? Reply @ratherrapid @ratherrapid 1 month ago Lots of questionable advice imo. Protein, creatine- = muscle cramps for a lot of people, melatonin dose a d timing, multiple constant eati g, etc. Reply @bartl.7390 @bartl.7390 1 month ago (edited) The conundrum of protein supplementation causing m-tor pathway stimulation (and thus aging) vs. maintenance of muscle has been solved by Centenarians living in blue zones. Blue zones Centenarians eat about 95% plant based diet. Plant protein has reduced levels of leucine, etc. and therefore appears not be a strong of an m-tor pathways activator. Personally I eat plant protein for most of the day and animal protein once a day to minimize m-tor activation but still reach the recommended levels as per Dr. Stanfield or Dr. Attia. Exercise is the key because it both helps to maintain muscle and selectively suppress m-tor. 1 Reply @stephenbrown2054 @stephenbrown2054 1 month ago You give some convincing evidence for Melatonin, but it seems to make my sleep worse. I can never sleep more than about six hours after taking it before bed (even if its only 300 mcg). Any one else have this problem? Reply @0xszander0 @0xszander0 1 month ago Sounds crazy to me that you're actually taking all of these. Are you simultaneously listening to how your body responds to them? That seems to be the key to me. A lot of individual variance with all of these supplements. This is also back by the literature. I personally got very tired from TMG. Cycled on and off and found out. Hyaluronic acid is a pain in the ass to supplement it just turns into a gel. Collagen peptides, why if you're already getting in lots of protein? And possibly eat some meat too? Psyllium husk, why if you're already getting loads of fiber in your diet? 4 Reply 3 replies @douggullickson1025 @douggullickson1025 1 month ago Dr. Stanfield - do you have any thoughts on urolithin a? Reply @petermilian4455 @petermilian4455 1 month ago (edited) Why do you focus so much on psyllium husk when ground flaxseed seems to offer additional benefits and lower contamination risk? Ground flaxseed functions similarly as a fiber supplement but also contains omega 3s (also in this list) and lignans. Ground flaxseed can also be sourced from farms in developed countries (US, CA etc.) avoiding the lead and other heavy metal / pesticide contamination risks that imported psyllium husk is known for. Is ground flaxseed not as readily available in New Zealand? Or is there something unique about psyllium husk that allows it to more reliably address dietary fiber deficiency? 1 Reply @jayonsee4946 @jayonsee4946 1 month ago There’s something inconsistent, first you say we are human not mice when the research don’t support what you suggest (protein powder), then you refer to mice study that support what you say (multivitamin). So what’s the standard? Should we believe or not on mice study? Reply @ShadeViking7 @ShadeViking7 1 month ago ⚡💯 1 Reply @aejiongco @aejiongco 17 hours ago He doesn't need to research much; health and nutrition podcasters tend to repeat the same information consistently. Reply @cocoarecords @cocoarecords 1 month ago Thank you Dr brad long time fam Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply @articles2757 @articles2757 1 month ago Doc said we are human and can not consider the effect on mice as a mirror and then he states 10:25 that mice study states the benefits of hyaluronic acid Reply @Fearzero @Fearzero 1 month ago The 50 year long 7 country study shows a strong correlation between ingesting more animal protein and shorter lifespan. This is now the basis of the blue zone diet. 4 Reply 2 replies @Governemntistheproblem @Governemntistheproblem 1 month ago Tmg is great. But raises TMAO and heart problems Reply @thaidomain @thaidomain 1 month ago Taking 10-15 gram of collagen peptides for 8 % less wrinkles, you can't be serious. This will not be something you can see with the naked eye. The same about the effect of hyaluronidase. It looks to be you would need at least a 50-75% reduction in wrinkles, to consider taking these supplements. 1 Reply @dorj46 @dorj46 4 days ago I was thinking ima take all the supplements this doctor mentioned with no question till he said soy doesn't affect testosterone Reply @donmulder8061 @donmulder8061 1 month ago I follow about 4 or 5 of these channels and incorporate supplements that seem to be clear of any harm signal. Even so, despite exercising daily for years and being very mindful of my diet and sleep and taking only the supplements that seem to be in the clear of potential harms, I got Afib two months ago. Out of the blue. Just drinking a cold smoothie and now I am getting an electrical shock. I stopped taking all the supplements. They didnt avoid this seemingly avoidable thing. 1 Reply 4 replies @ludeeilert8660 @ludeeilert8660 1 month ago Dr Brad, i am a woman, creatine cause hair loss! Our bodies are different, impact of supplements varies. I do enjoy your videos - thank you 😊. 3 Reply 2 replies @sisi2754 @sisi2754 1 month ago Pls make a topic Supplements that benefits MENTAL HEALTH Reply @adelarsen9776 @adelarsen9776 3 weeks ago If you just eat lots of fatty red meat and animal products then you don't need supplements. 1 Reply @themeinge @themeinge 1 month ago @DrBradStanfield Could you do a video on Urolithin A and probiotics for converting ellagic acid onto urolithins? Reply 1 reply @okamsug @okamsug 1 month ago Never heard much of TMG before, but definitely no creatine for me. It raises my creatinine level which alarms my doctor and tells me to stop taking it. 1 Reply @mrsmith5114 @mrsmith5114 1 month ago Andrew Huberman disagrees with your strongly about taking any melatonin and lists very good reasons. Not just because you might take a high dose or you have no real idea what dosing is really in the bottles. Reply @liborslany189 @liborslany189 1 month ago You used to recommend high molecular weight hyaluronic acid. What changed your mind? 1 Reply @paulgee3411 @paulgee3411 11 days ago I thought he knew what he was talking about - until I got all the way to the 8min mark, to the part where he said "reducing cholesterol - especially LDL..." Then I knew he was just spouting stuff without really reviewing the current state of the literature. (and not the studies funded by the statin industry) Reply @2023betterresearch @2023betterresearch 1 month ago You do not specify which type of Omega 3...which quantities and more DHA than EPA or the reverse? Reply @irawurtz @irawurtz 1 month ago I love your content and watch your videos, but do you not think it's hypocritical to refute longevity experts theory on low protein diet because "we're not mice", and then use mice trials throughout the rest of the video to support your points? 1 Reply @aronlane4664 @aronlane4664 1 month ago The muscle one might just be correlation , methionine restriction works with rats too and they are an omnivorous mammal like us , I'm not sure but neither are you but you act like it's proven . Also if we're just looking to build muscle and assume that anything that does that must be good then it means bodybuilders should be aging well , except they don't in general Reply @VitalyGG @VitalyGG 1 month ago I took Glycine, Nac, Marine Collagen, Hyaloronic acid, Gliucosamine and got fibromyxoma in my upper arm. After surgery- 3cm scar... Maybe it's not related, but no thanks, any skin supplements anymore )) Reply 2 replies @Kaztrofy @Kaztrofy 1 month ago What about HMB? 1 Reply @HeartFeltGesture @HeartFeltGesture 1 month ago I get little red bumps all over my chest and stomach when I take Creatine, anyone else? Reply 1 reply @wocket42 @wocket42 1 month ago I eat about 6-8g of Creatine per day in whole foods. Probably no supplements needed? Reply @miiitchhh225 @miiitchhh225 1 month ago Is it ok to crush Microvitamin? It’s a bit large for my swallowing abilities lol 1 Reply Dr Brad Stanfield · 1 reply @finalfan321 @finalfan321 1 month ago wait did you not say HA has to be of high molecular weight??? 2 Reply @totallyraw1313 @totallyraw1313 1 month ago When I'm in New Zealand, I like to eat a lot of fush 😄 Reply 1 reply @chasingshangrila @chasingshangrila 1 month ago What about CAKG for longevity? 3 Reply 2 replies @nicoleheatherington4365 @nicoleheatherington4365 1 month ago Wonder what Dr Stanfield thinks of Dr Huberman “‘s recommendation of apigen, l threonate and l theanine for sleep.? Reply @kenc4104 @kenc4104 1 month ago I take glycine daily, does that offer the same benefits as TMG? 2 Reply 1 reply @KvasirBlut @KvasirBlut 1 month ago Would like to use marine collagen but dont know if its as good as collagen peptids...😑 1 Reply 1 reply @sergeys2505 @sergeys2505 1 month ago What about astaxantin, man? Reply @sanesp1025 @sanesp1025 1 month ago Half milligram of melatonin sublingual gets me fall asleep in 20 minutes 1 Reply @danbelcher4751 @danbelcher4751 1 month ago I did creatine for over a year it did absolutely nothing for me Reply 1 reply @rfbead321 @rfbead321 1 month ago In a nutshell, eat 1kg of grass-fed ruminant meat every day to keep the doctor away! 1 Reply @KillaCommieFerMommie @KillaCommieFerMommie 1 month ago No garlic or DHEA supplements?.... interesting 1 Reply @allboutthemojo @allboutthemojo 1 month ago It's important to remember that we are not mice ! ✅️ Reply @milkshakefrydip1671 @milkshakefrydip1671 1 month ago (edited) This prob the 4th time I ask and never got a response . What should I take if I’m allergic to creatine ? 2 Reply 1 reply @nypdbob @nypdbob 1 month ago Thank you Reply @vethum @vethum 1 month ago I used creatine and noticed hair loss. I stopped creatine and am back to normal hair. 5 Reply 9 replies @didotbasmayor @didotbasmayor 1 month ago how about your subscriber from. Philippines, id like to buy your vitamins but shipping is not available for our country? Reply @leonardoguimaraes7063 @leonardoguimaraes7063 1 month ago We only need 2g of creatine Reply @susymay7831 @susymay7831 1 month ago (edited) What type of protein powder? Example: whey or pea? 1 Reply 2 replies @666LatinoCad @666LatinoCad 1 month ago Add time stamps to your videos Reply @frankschaeffer8153 @frankschaeffer8153 1 month ago Yeah you can pay lots of money for collagen supplements. Or eat gelatine. Reply @jonfairway8235 @jonfairway8235 1 month ago Rosuvastatin ???? linked to higher chance of getting diabetes >? why would you risk that to lower LDL ? Reply @alans177 @alans177 1 month ago 👍 Dr Brad Stanfield Reply @yuyang4628 @yuyang4628 3 weeks ago I'm surprised that fish oil has no benefit in promoting cognition Reply @snake1625b @snake1625b 1 month ago First time hearing of tmg Reply @yohannb5910 @yohannb5910 1 month ago this video was already published before, ridiculous to mark it as new, it's old stuff Reply @aejiongco @aejiongco 17 hours ago The worst thing I have heard is using protein powder. Lots of unwanted chemicals, and a process food. Reply @wocket42 @wocket42 1 month ago 9:13 hydrolyzed collagen was not compared to protein, but to soy protein. Says it on the screen! So probably a study that shows that plant protein isn't a good source of protein. Reply @SyriusStarMultimedia @SyriusStarMultimedia 1 month ago I am not a mice. Got it. Reply @timmyhiggins5220 @timmyhiggins5220 1 month ago Supplements that work.......but they don't really... Reply @yttean98 @yttean98 1 month ago Dr. Bradfield, I watched 1/2 doz your videos over 2 yr period, you must taken lots of supplements during that period your above video your face looks a little puffy could it be due to the supplements? I mean this as a genuine query. 1 Reply @saaydbrionesdelagarza222 @saaydbrionesdelagarza222 1 month ago You are incongruent , you say we are not mousses, so we need more protein, but you still recomended taurinate magnesium because it works on mousses, i like your work but you need to use more this words: maybe i can be wrong, but for now i think this is the best for me Reply @furiousdoe7779 @furiousdoe7779 1 month ago We are not mice. 1 Reply @donwinston @donwinston 1 month ago Mice don't fall down and break their hip when they get old. 1 Reply 3 replies @kweikwabena3822 @kweikwabena3822 1 month ago so if you agree with findings..it is ok if mice were used .....but if you do not agree....'we are not mice' Reply @bonanzatime @bonanzatime 1 month ago I AM A MAN! NOT A MOUSE!! Reply @leodi4169 @leodi4169 1 month ago Don't agree with the recommended protein intake. Centenarians from the blue zones report consuming 0.6 to 0.8 grams of protein per kilogram of bodyweight or even less... Reply @wocket42 @wocket42 1 month ago Just eat natural red meat and drink bone broth. Reply @Fearzero @Fearzero 1 month ago (edited) Excess animal protein shortens lifespan. 5 Reply 2 replies @Saintor1 @Saintor1 1 month ago We are not mice is NOT an argument, without more supporting FACTS. 2 Reply 1 reply @labrosathanasopoulos7749 @labrosathanasopoulos7749 1 month ago you need to be rich that sounds expensive Reply @3695v @3695v 1 month ago You could say what are you taking? 1 Reply 1 reply @usmanali81 @usmanali81 1 month ago Why you made 3 videos on the same topic??? All in one year Reply Dr Brad Stanfield · 2 replies @knowledgelover2736 @knowledgelover2736 1 month ago Those omega 3 trials put people on omega 3 too late. It requires a lifetime of use. Bad study design. Reply @blaze1148 @blaze1148 1 month ago Dr Brad is a grifter .....always trying to sell supplements with marginal benefits. 1 Reply @Theo-ly6nn @Theo-ly6nn 3 weeks ago Too many YouTube ads.I always delete videos with ads as I don't consider them educational. Reply @moshmorok @moshmorok 1 month ago Please go and see centenarians protein intake and understand that these protein assumptions are total ehit Reply @noodler8874 @noodler8874 1 month ago Just eat real food! 1 Reply @justinbattle3705 @justinbattle3705 1 month ago Bingo Reply @cryptoallstar8904 @cryptoallstar8904 1 month ago Are you a doctor or a body builder? Protein powder is bad for you ser. Reply 1 reply @duc1198s @duc1198s 1 month ago A bit of inconsistency here. Saying that studies show that taurine has benefit, but earlier in the video saying that humans are at mice and we should not draw conclusions from that study. Reply @ahairystick6304 @ahairystick6304 1 month ago 😢 Reply @seleukoskallinikos @seleukoskallinikos 1 month ago guys dont listen to him, this is madness 6 Reply 3 replies @thehappyfellow5500 @thehappyfellow5500 1 month ago Says that low protein isn't good because the benefit of it was shown only in mice studies. Also says that taurine good because shown in mice study... . High protein in young adults makes less likely for them lose mucles as they age because they don't get to a very old age 😂. Protein benefits for mucles are show in old people, young should get less. Your views on protein are dumb. Reply @DuderofDudeness @DuderofDudeness 1 month ago All of them can be a waste of money and most can be harmful. 5 Reply 3 replies @1956DANNYJ @1956DANNYJ 1 month ago Your wrong about soy Reply @peoplearecrazy1798 @peoplearecrazy1798 1 month ago Please learn how to say against and your r’s. 1 Reply @dollarbill9073 @dollarbill9073 1 month ago Do you think next time you could comb your hair and shave your face? You literally look like you just rolled out of bed and through a shirt and jacket on. 2 Reply