lifespan book review

From the United States S. Mims 4.0 out of 5 stars One of the most important books that I’ve read in the past decade. Reviewed in the United States on October 28, 2019 Verified Purchase Lifespan: Why We Age – And Why We Don’t Have To This is one of the most important books that I’ve read in the past decade. I’ve been excited about scientific progress against aging for the past 40 years, and have been taking supplements of various kinds since I was in my 20’s. David Sinclair’s book details most of the real progress in the field, with the best examples coming rather recently – in the past few years. Sinclair exudes optimism, which matches my own natural tendency. As a narrative, the book succeeds in bringing the reader to an understanding of David’s initial motivation in his field, using the story of his grandmother Vera’s lifelong vitality giving way to decline and, ultimately, death. The reader also gets an historical retracing of the road to knowledge of telomeres, CRSPR, Sirtuins, and cell reprogramming. Did you know that there were sharks that have had life spans measured to have exceeded 500 years? Twice, while in bed reading the book late at night, I bolted upright when a new fact was revealed. The first wake-up was an anecdote in the book about one of Sinclair’s researchers coming to him for help on an issue with the young man’s mother. Seems she had started having menstrual periods again after starting to take a supplement (NMN, I think) that many on David’s research team were taking themselves. Another shock was hearing of the reprogramming of optic tissue cells, using 3 of the 4 activators known to enable an adult cell to become a pluripotent stem cell. The 3 activators were CRSPR’d into the DNA of the receiving tissue, along with an activation mechanism that depends on receiving a certain antibiotic. So, dosage modulated regeneration of Optic nerve tissue was achieved in rats. That fact opens up the possibility of not only slowing or stopping aging, but actually reversing it. The first half of this book covers the history and amazing scientific discoveries, but unfortunately the second half oozes with virtue signaling as it reveals David to be an altruistic collectivist with all manner of political prescriptions he thinks are needed to save humanity from itself – from gun control to climate activism. I suppose it is inevitable that the progressive bubble of an academic environment blinds its inhabitants by disallowing any political disagreement. However, it made me come to question Sinclair’s own scientific rigor. If he hasn’t read of the hiding of temperature data, and suspiciously always lower “adjustments” to past temperature records which is central to the global warming hoax, what alternative aging hypotheses might he be ignoring as well? I dug into this a bit, after remembering that GlaxoSmithKline spent nearly a billion dollars back in 2008 for one of David’s startups working on Sirtuins (Sirtris). Back then, I was hoping that we’d see new anti-aging pharmaceuticals within a decade. Glaxo shut down the unit in 2013. That sounds ominous, right? But, comments on Glaxo’s page say that core researchers were offered positions in other parts of the company, and that Glaxo still thought the Sirtuin drug candidates were valuable. In the book’s “Cast of Characters”, it is stated that Elizabeth Blackburn was “controversially dismissed” from Bush’s Council on Bioethics “allegedly for her advocacy of stem cell research and politics-free scientific inquiry.” What’s missing from this statement is that said advocacy was for “embryonic stem cell research”. Bush’s constituency believed that this meant using human lives (albeit very young lives) for research, and this constituency did not want their tax money to pay for what they considered an immoral act. Again, the book seems to be using the material to make political jabs. Perhaps Dr Sinclair doesn’t realize this, perhaps he does. Much is also made in the book’s second half about trying to guarantee that anti-aging therapies would be made available to all, regardless of cost. I would hope that the examples of pricing in the space, auto, and computer industries show how capitalist countries succeed in bringing costs down for everyone, without government mandates. Space Shuttles used to cost roughly $20,000/kg for orbital flights. SpaceX has brought that cost down to around $2,000/kg. It is still way too expensive for the average American tourist. However, cars were once only affordable to the wealthy. Henry Ford employed capital to force down prices, extending affordability to the middle class. Prices start out high, which enables start-ups to raise capital. Then as volume goes up, unit costs are driven lower by competition. That’s how we got to 256GB USB sticks for $32. I once paid $10,000 for 0.004% of that much space. Drug prices would be driven down faster if the FDA only mandated safety testing, instead of both safety and efficacy. If drugs are guaranteed by the FDA to be safe, then we consumers should be allowed to try anything we want. Companies that want more market share would pay for efficacy trials, the results of which could be used in advertising. Drug development costs/prices might drop by 90% in that kind of market. Sure would cut the wait time for anti-aging therapies. 127 people found this helpful Helpful Report lucinda 5.0 out of 5 stars This book changed our life! Reviewed in the United States on November 27, 2023 Verified Purchase Every senior should read this book, but have a dictionary available because it can get technical. When all doctors want to do is dispense pills and treat illness - it is refreshing to embrace health and wellness. A well documented book. Helpful Report The Hobbyist 5.0 out of 5 stars Brilliant book from a brilliant man! Reviewed in the United States on October 10, 2023 Verified Purchase David Sinclair is a very big deal in the world of longevity, and he brings unparalleled knowledge to the masses with this book. I have the CD set, and it actually has some updated information from the book. I wasn't sure about listening to this book on CD, But Dr. Sinclair does an absolutely exceptional job of orating some very important and also very technical research results. What a time to be alive! 4 people found this helpful Helpful Report Tom Hunter 5.0 out of 5 stars If you read one book this year--let it be this one. It will show you how to live a longer life! Reviewed in the United States on December 20, 2021 Verified Purchase Of the 34 books I have completed reading this year, this is the best. Pay close attention to the subtitle. Though as we age, it's natural for humans to focus more and more on extending their lives--this book, written by the world-leading authority on aging and what it will take to extend our lives, gives concrete actionable guidance on what you personally can do to increase your life: * It shows the already known value of fasting, in that the act of skipping meals causes the body to switch to a life-extending mode. That means you at the very least skip breakfast. Your goal is to go as long as possible every day without eating. * It shows how the commercially available supplement NMN, a precursor to NAD, can have direct and noticeable effects on one's health and lifespan. * It shows how lots of small effects, such as exposing yourself to extreme cold for brief periods of time also triggers your body's natural life-extending mechanisms. I am not attempting to reproduce a 310-page book. To fully understand, read this book or the many follow on talks given by the same author. Sinclair begins this book by describing the "information theory of aging". Until his theory, the generally accepted idea has been that aging comes when the "digital" information that is held on DNA using the 4 base pairs becomes corrupted through information loss. Sinclair posits that aging is not a result of the corruption of DNA (which the body can fix) but the corruption of the companion to DNA that controls gene expression, the epigenome--which is separate set of chemicals and proteins that GOVERN how the DNA map is used to build proteins. Sinclair shows that it's possible to correct these epigenomic errors. The mechanism for doing this is quite interesting. It has been used to cause a damaged mouse optic nerve to re-grow. Absolutely fascinating and plausible in terms of the science involved. So, I will give you what you came here to see. The author near the end gives his own personal regime for extending his life: * 1,000 MG NMN supplement every morning * 1,000 MG resveratrol every morning * Daily dose Vitamin D, Vitamin K, aspirin * Keep sugar, bread and pasta intake as low as possible. * Allow yourself to be hungry for part of every day. Delay your first meal of the day as late as possible. * Skip one meal a day or at least make it really small. (Try to go as long as possible between eating.) * Lift weights * Expose yourself briefly to extreme cold, because that also triggers your body's survival mechanisms. This was a great and interesting read that I tore through. In no cases did the author make logical fallacies. It was scientifically convincing and legitimate-seeming all through. If you read one book this year--let it be this one. It will show you how to live a longer life. 92 people found this helpful Helpful Report Paul H. 5.0 out of 5 stars Very Informative and Fun to Read Reviewed in the United States on September 22, 2023 Verified Purchase I really enjoyed this book. David A. Sinclair AO and Author Matthew D. LaPlante did a great job of delivering a ton of information to the reader (in this case, me!) and still managed to make it lighthearted and enjoyable to read. After reading this, I have a feeling my life is not only going to be longer, but a whole lot healthier too. 5 people found this helpful Helpful Report Andrea Pgh 5.0 out of 5 stars Excellent Read; Excellent Author Reviewed in the United States on January 20, 2020 Verified Purchase This book is a very comprehensive view of not only the current research in anti-aging, but a sincere consideration of the implications of prolonging average lifespan and health span. Dr. Sinclair makes the science understandable while also bringing personal passion to the issue of aging and long-term health - it really means something for him. The book discusses WHY we age at a biological level, what that means for the pathways in which to stop that biological process, and the current research of what health practices, lifestyles, and most importantly which molecules can prevent or slow the process. After all, our bodies do not simply say "Well, looks like we are 60, time to start shutting down." There must be something happening at a cellular and biological level in our bodies that causes us to be "60" and not "20", so what is it? And given that there must be a process, why should it be impossible to intervene in it? On this premise, Dr. Sinclair discusses how a loss of information and DNA degradation contributes to a loss of cellular function that precipitates aging. He then goes on to explain not just THAT diet and exercise are helpful in increasing health span, but WHY - a much more scientific approach than just saying "eat your grems, they're good for you." Beyond that, and most interestingly, he relates the latest research on naturally-occurring molecules that can reactivate cellular function, and the promise such molecules may have - which to-date have demonstrated little to no negative side-effects and have moved into human trials. Because Sinclair himself is leading much of the research in his Harvard lab, this is not just another health book from another health guru attempting to peddle "advice" for money. It is a true attempt to communicate actual findings from esteemed research laboratories, and an attempt to do so so that the public can understand the latest science themselves instead of waiting for a patented pill to be offered via a doctor's office years from now with only half-baked information. I also want to note that, per his numerous statements in public forums, interviews and the book itself, Dr. Sinclair does not promote or profit from the sale of any commercial product - such as NMN, Resveratrol or NR. Though his name is invoked on many websites to give clout to commercial products, he makes a point to never endorse or sign a deal with any such commercial producer, precisely so that his integrity and the validity of the research cannot be called into question. Any stake that he has in any related company is disclosed and the nature of the involvement discussed, but again, he purposely does not profit from or endorse any commercial product. Personally, I recommend coupling or preceding the book with podcasts on which he has been a guest so that you can get a light, layman's background in the science before delving into the depth of the text itself. While the text is reasonably easy to follow, the information is still weighty and may be benefit from hearing a more high-level version first. 12 people found this helpful Helpful Report Blackbird 4.0 out of 5 stars great and important book, but with deficiencies Reviewed in the United States on August 30, 2022 Verified Purchase This is a well written and deeply researched book written by an expert in the field, with the help of a professional writer, that focuses on research, gene therapies and supplements that are intended to extend human, and even non-human, lifespans. As such, it succeeds brilliantly as it presents a wealth of material in a concise introduction to the subject and provides an excellent review of what he and other aging researchers and geneticists have learned up to 2019. Where I think the book falls short is in more thoroughly linking the effects of diet on health and in making, even in an Appendix, specific dietary recommendations, both pro and con, and providing a more thorough basis for the reader to make informed decisions. Yes, there are many other books that do this, but they do not provide the related genetic and supplement information, so readers are required to look in multiple volumes to get a more complete view of linkages between diet, health, and longevity. The book also makes very few references to exercise although it encourages the reader to be active every day. I think that a second edition of this book could be more useful by providing the core information covered in this edition, and updates, plus specific recommendations on what to and not to eat (or specific recommendations on where to get that information) as well as what kinds of exercise are recommended for each age group (or where to get that information). The obesity epidemic so prevalent in Western countries and food insecurity issues prevalent worldwide are not mentioned, and probably ought to be. There is emphasis at the end of the book on global food waste and on consumerism, and how these affect the planet's ability to sustain increasing human populations, but these are not integrated into the overall thesis that great strides in extending human lifetimes are upon us and solutions are not offered. A very thought-provoking book and one which offers a very optimistic view of the future, but one that I think ought to be expanded to integrate diet and exercise into the theme of extending lifespan. 35 people found this helpful Helpful Report Opinionated 5.0 out of 5 stars Easy to use Reviewed in the United States on October 5, 2023 Verified Purchase Much to learn about health and longevity in this book by the famous Dr Sinclair. One person found this helpful Helpful Report john doba 5.0 out of 5 stars Entering the age of miracles & sci-fi Reviewed in the United States on March 19, 2023 Verified Purchase One of the world's leading aging researchers shows here it's not inevitable that we suffer a miserable, debilitated and perhaps senile finish. He offers not just some great health ideas, but a truly radical (and genuinely hopeful) new worldview, a revolutionary paradigm-shift on what it means to be a human being--it's that good. A bold new information-theory approach to aging--now already in place in leading labs---perhaps may make possible incredible sci-fi outcomes: regenerating lost limbs; actually reversing aging, through cellular reprogramming and other methods; and maybe even immortality one day. To those who say this is playing God: we've been doing that a long time. Our kind's quasi-divine creativity----"made in the image of God," according to the Bible---has already created many miracles; we've put men on the moon, eliminated smallpox, and brought ourselves up from the caves, by human ingenuity. To deny our own further self-improvement, would be the truly unnatural thing. And he backs this view up with some unexpected and startling economic and hard-nosed money views that persuade me he's right: aging we should see as a disease, that not only can be treated and cured---but must be, if we are going to survive as a species on this increasingly crowded and politically dangerous planet. The view looks a bit socialistic to my conservative American brain, but there's no going back to the caves---or so we hope. A game-changer, but will it be in time? Our clock, individually and collectively, is ticking. 15 people found this helpful Helpful Report Jaime S 5.0 out of 5 stars Arrived on time in good condition. Reviewed in the United States on September 29, 2023 Verified Purchase Arrived on time in good condition. It is what I ordered. It was what I ordered. Helpful Report Lifespan - David Sinclair, PhD (overview & thoughts) The Sheekey Science Show 39.8K subscribers Subscribe 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 Share Clip Save 18,135 views Dec 28, 2019 I recently read "Lifespan - Why We Age - and Why We Don't Have To" by David A.Sinclair PhD, so I have made a video summarising the key messages from the book and also my thoughts and opinions on it! It was hard to summarise everything in 12 mins without revealing too much from the book, so you should go buy and read the book for yourself! Lifespan - https://amzn.to/3QVW3KB Is Calorie restriction legit - • Is epigenetic aging reversible? Eric Topol - Deep Medicine (REVIEW) - • Deep Medicine - Eric Topol (Overview ... Chapters View all Transcript Follow along using the transcript. Show transcript The Sheekey Science Show 39.8K subscribers Videos About 4:37 What are the hallmarks of aging? by The Sheekey Science Show 7:42 Is calorie restriction legit? by The Sheekey Science Show 9:01 Deep Medicine - Eric Topol (Overview & Thoughts) by The Sheekey Science Show 43 Comments rongmaw lin Add a comment... @doratheillegalalien9183 Pinned by The Sheekey Science Show @doratheillegalalien9183 3 years ago you need a hell of a lot more subscribers and views 21 The Sheekey Science Show Reply @moshefabrikant1 @moshefabrikant1 1 year ago (edited) 1:30 Your cells getting old is like a cd which is new getting more and more scratched till it's not useable 3:30 Caloric restriction helps live longer 7:00 MMN is great drug 8:00 Exercise more. 8:1/ Go out the termonetural zone. Do cold shower Go outside when it's cold. Do sauna 10:30 Interesting 12:13 Old age is a diesase 6 Reply 1 reply @larrykraft2743 @larrykraft2743 2 years ago I’ve recently come across your channel and I’ve greatly enjoyed several of your videos. Thank you very much for the energy and time you have put into A, getting so smart and B, making such important information accessible to the rest of us! If I may make one suggestion (and please excuse me if you’ve already adopted this in later videos), could you please add like a 2 second pause whenever you get done building an image before jumping to a new image? For example, at about 4:45 in this video I had a hard time discovering what the final E in that acrostic was for. I finally had to slow it down to 1/4 speed to see that the final E in CALERIE (sic) was for “energy.” I look forward to watching your video on calorie restriction. For a good laugh take any speech from anyone and slow it to 1/4 normal speed. It makes them sound like they’re half asleep. Thanks again! 1 The Sheekey Science Show Reply @Natalia-Millan @Natalia-Millan 6 months ago Thank you, i don't have any background in science therefore it was hard for me to follow this Author, however you summarized the information in a really simple and visual way! Also, since I am not a native English speaker, seeing how you write the words and pictures on the screen facilitated the job and made it very visual for me so now I can retain a few concepts . Reply @intaek60 @intaek60 2 years ago I bought the book and read the first part of it. Your concise video is very helpful in summarizing the book. Thank you! 2 The Sheekey Science Show Reply @deasmiles @deasmiles 3 years ago I loved this, you broke it down and made it easy to understand. Thank you! 6 The Sheekey Science Show Reply The Sheekey Science Show · 1 reply @hollywoodianiit516 @hollywoodianiit516 2 years ago Hi Eleanor! May I suggest you to read the book "Cracking the aging code" that presents a very original theory of aging that I found very compelling. It is not much about the biochemical mechanisms but more about the evolutionary underpinnings. That could be another video idea... 2 The Sheekey Science Show Reply The Sheekey Science Show · 1 reply @robertscott1660 @robertscott1660 2 years ago Dear Sheeky , I enjoyed Sinclair's book very much and your review is helpful. Sinclair is a serious researcher who has devoted his career to understanding the biology of ageing. But after reading Andrew J Steele's book "Ageless" and delving into the literature, partly with the help of your channel, I find Sinclair's perspective rather narrow. He claims to have found the theory of ageing, yet other researchers in the field seem to tell a more complicated story. The 2013 review article by Lopez-Otin et al., seems to be quite influential with over 7000 citations on Google scholar. They cite 9 halmarks of ageing, one of which is epigenetic alterations and seems to include Sinclair's work on sirtuins. In other words, perhaps epigenetics is important to ageing but there is much more too it. For example, one might ask how are pathways involving sirtuins going to help us live longer if we die of a heart attack or stroke because of increased blood pressure because the artery walls lost the flexibility to expand? 2 Reply 1 reply @G3orgianSoldier @G3orgianSoldier 2 years ago I am a mathematician and have just made a presentation about Claude Shannon's works in my university. It's so cool to see it here :D 2 The Sheekey Science Show Reply @katiescarlett5249 @katiescarlett5249 2 years ago (edited) Great review! Who was the scientist that came up with the Free Radical Theory of Aging? Each copy of the cell that is made after the Free Radical Damage has been done, is like a bad xerox copy till the original is very different from the copy. Inflammation is the same premise. Then the activation of the SIRT 1 Gene has been something that has been discussed in the past as well. Mitochondrial has not been addressed by anyone except physicians active in Chronic Fatigue Syndrome. So that would be interesting. Reply @pickaxingoneuropa8457 @pickaxingoneuropa8457 1 year ago These book reviews keep getting better and better. 🐳 Reply @bjorn2fly @bjorn2fly 3 years ago Nice video, still a problem with the microphone, but better than last video. Also In many countries Metformin is without prescription. Also loved your last video on aging, pity you dont get a bigger audience here on youtube, but maybe you can live forever, now that you know so much about reversing ageing :-) 3 Reply The Sheekey Science Show · 1 reply @adriansolis7760 @adriansolis7760 1 year ago Feels like I'm back in my college adv. Bio Chem class 💯 great video The Sheekey Science Show Reply @scottherf @scottherf 3 years ago Thanks Sheeky, Lifespan is jampacked but really fascinating reading. 3 The Sheekey Science Show Reply @yusunliu4858 @yusunliu4858 2 years ago After listening to your several videos, my eyes can not stop following your sketching and writing. 1 The Sheekey Science Show Reply @simplrhealthctf @simplrhealthctf 2 years ago For the resveratrol side, the issue is with bio availability. And wine and absorbing through the lining of the mouth is the most bio available process. And while true as to the amount of wine required to be effective, dr Phil Norrie has developed “the wine doctor” wine and resalixer. So in the case of the resilixer, you take 50ml and rinse around your mouth for a few min and it’s the equivalent resveratrol to 10 bottles of red wine. While the bottle of wine doctor wine contains the equivalent resveratrol to 20bottles of red wine. Feel free to contact for more info Reply 1 reply @jayahn9399 @jayahn9399 3 years ago Thank you very much for the concise and artistic presentation. I liked also your English accent. 8 The Sheekey Science Show Reply 1 reply @thepathofeudaimonia947 @thepathofeudaimonia947 1 year ago Searching for "Lifespan summaries" got me here, and I am so happy for finding your channel! The Sheekey Science Show Reply @yavuzbahadrtaktak8020 @yavuzbahadrtaktak8020 1 year ago nice and precise. here is a thing: if scientists manage to achieve prolongation of life and if it will be accessible to anyone, human population will exponentially grow (do we have enough energy to keep growing and keep nature clean :P); if it stays as a privilege in rich guys' hands as Harari mentioned we are creating superhuman beings. Reply @emmanueltrejo3531 @emmanueltrejo3531 3 years ago Excellent, thank you very much 1 The Sheekey Science Show Reply @kirasenna6054 @kirasenna6054 2 years ago is a hot shower also considered a thermoneutral zone? i would prefer this over a cold shower though Reply @ZombieProdigyUS @ZombieProdigyUS 3 years ago (edited) I have a question! :) He claims that we need to put our body into "stress modes", to activate our sirtuins, and that by doing so, they will help repair damage caused by "epigenetic noise." The thing Im not understanding is that he says sirtuins going back in the wrong spots sometimes and slicing genes not meant to be sliced, is what causes aging. So why on Earth would we ever want to send out more sirtuins??? Maybe I'm confused here, but why is moderation good? I know it is, but why is almost all activity not harmful?? Say even weight lifting, where you tear your muscles to build new ones. He says that fine, but why?? Would that not causes sirtuins to repair and then maybe go back into the wrong places??? Thanks so much for helping! :) 1 Reply @christopherellis2663 @christopherellis2663 2 years ago (edited) I'm reading the Romanian edition. (The editor cannot decide whether it's Sydney or " Sidney. The Spaniards are similar confused" The FDA is an American problem. Reply @Buzz231094 @Buzz231094 2 years ago This was interesting The Sheekey Science Show Reply @gioloogy @gioloogy 3 years ago Nice video and work 1 The Sheekey Science Show Reply The Sheekey Science Show · 1 reply @walterjab @walterjab 3 years ago Nice, thank you. 1 The Sheekey Science Show Reply The Sheekey Science Show · 1 reply @Jz-en9pi @Jz-en9pi 3 years ago Thanks! 1 The Sheekey Science Show Reply @huydao9802 @huydao9802 4 months ago thank you BOOK SUMMARY: Lifespan: Why We Age and Why We Don't Have to — David Sinclair Book Success 5.36K subscribers Subscribe 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 Share Download Clip Save 6,135 views Sep 12, 2021 In this book summary, I’m explaining the key ideas of David Sinclair's book: "Lifespan: Why We Age - and Why We Don't Have to". In more detail, we're discussing the following topics: 1. Why do we age? (0:35 - 2:14) 2. What can we do to slow down the aging process and reverse it? (2:15 - 7:35) 2.1. Eat less (3:04 - 4:12) 2.2. Exercise more (4:13 - 4:50) 2.3. Expose yourself to extreme temperatures (4:51 - 6:19) 2.4. Supplement yourself (6:20 - 7:35) Want to read the entire book? Click here: ​https://amzn.to/3lgqpsX Here is also a blueprint for how a day in the author's life looks like: - David takes 1 gram (1,000 mg) of NMN every morning, along with 1 gram of resveratrol and 1 gram of metformin - David takes a daily dose of vitamin D, vitamin K2, and 83 mg of aspirin - David strives to keep his sugar, bread, and pasta intake as low as possible. He eats a lot of plants and tries to avoid eating other mammals. - David tries to skip one meal a day or at least make it really small. - David tries to take a lot of steps each day. - David doesn't smoke. He tries to avoid microwaved plastic, excessive UV exposure, X-rays and CT-scans. - David tries to stay on the cool side during the day and when he sleeps. - David aims to keep his body weight or BMI in the optimal range for health span, which is 23 to 25 for him. Cheers, Anthony Chapters View all Transcript Follow along using the transcript. Show transcript Book Success 5.36K subscribers Videos About 9 Comments rongmaw lin Add a comment... @booksuccess9836 Pinned by Book Success @booksuccess9836 2 years ago Hi guys, hope you enjoy this video. Leave a comment and let me know if you learnt something new :) 2 Reply @jimacarr @jimacarr 1 year ago Thanks for the great work summarizing the book. One point of clarification is that supplementing directly with oral NAD is not recommended since NAD is not absorbed (due to the size of the molecule and other factors). Rather, Sinclair (and others) supplement with a NAD precursor such as NMN or NR. These are converted by the body into NAD+, which increases mitochondrial energy, thereby reducing the rate of aging (or so it is claimed). 1 Reply @Kommentar125 @Kommentar125 2 years ago loving the detailled boom summaries <3 (I'd love even longer/mire in-depth discussions) 3 Reply Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52 Andrew Huberman 4.43M subscribers Subscribe 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 K Share Download Thanks Clip Save 2,974,206 views Dec 27, 2021 Huberman Lab In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022. In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it. #HubermanLab #DavidSinclair #Longevity Thank you to our sponsors: ROKA - https://www.roka.com/huberman InsideTracker - https://www.insidetracker.com/huberman Magic Spoon - https://www.magicspoon.com/huberman Dr. David Sinclair Links: Lifespan Podcast: https://lifespanpodcast.com Twitter: / davidasinclair Instagram: / davidsinclairphd YouTube: / davidsinclairpodcast Lifespan (book): https://amzn.to/3mAZQjF Aging Test Waitlist: https://www.tallyhealth.com Harvard Lab Website: https://sinclair.hms.harvard.edu Our Patreon page: / andrewhuberman Supplements from Thorne: http://www.thorne.com/u/huberman Social: Instagram - / hubermanlab Twitter - / hubermanlab Facebook - / hubermanlab Website - https://hubermanlab.com Newsletter - https://hubermanlab.com/neural-network Timestamps: 00:00:00 Dr. David Sinclair, Harvard Medical School 00:03:30 ROKA, InsideTracker, Magic Spoon 00:07:45 “Aging as a Disease” vs. Longevity & Anti-Aging 00:10:23 What Causes Aging? The Epigenome 00:15:53 Cosmetic Aging 00:17:15 Development Never Stops, Horvath Clock 00:20:12 Puberty Rate as a Determinant of Aging Rate 00:23:00 Fasting, Hunger & Food Choices 00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy 00:34:50 Caffeine, Electrolytes 00:35:56 Blood Glucose & the Sirtuins; mTOR 00:37:55 Amino Acids: Leucine, “Pulsing” 00:44:35 Metformin, Berberine 00:50:29 Resveratrol, Wine 00:53:20 What Breaks a Fast? 00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing 01:09:10 Are Artificial Sweeteners Bad for Us? 01:12:04 Iron Load & Aging 01:15:05 Blood Work Analysis 01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary 01:26:02 Amino Acids, Plants, Antioxidants 01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen 01:40:35 Neuroplasticity & Neural Repair 01:46:19 Ice Baths, Cold Showers, “Metabolic Winter” 01:48:07 Obesity & How It Accelerates Aging, GnRH 01:52:10 Methylation, Methylene Blue, Cigarettes 01:56:17 X-Rays 01:59:00 Public Science Education, Personal Health 02:05:40 The Sinclair Test You Can Take: www.doctorsinclair.com 02:08:13 Zero-Cost Support & Resources, Sponsors, Patreon, Supplements, Instagram The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Audio Engineering: Joel Hatstat at High Jump Media Chapters View all Explore the podcast 171 episodes Huberman Lab Andrew Huberman Podcasts Transcript Follow along using the transcript. Show transcript Andrew Huberman 4.43M subscribers Videos About 4,691 Comments rongmaw lin Add a comment... @hubermanlab Pinned by Andrew Huberman @hubermanlab 1 year ago (edited) The first episode of Dr. David Sinclair's new podcast launches Wednesday, January 5, 2022. You can subscribe now to that podcast, "Lifespan with Dr. David Sinclair", on all podcast platforms ( https://lifespanpodcast.com ) and here on YouTube: https://www.youtube.com/davidsinclairpodcast. Thank you for your interest in science! 1K Reply 110 replies @1234highman @1234highman 10 months ago I'm extremely impressed with Dr. Sinclair's insights on aging - it's incredible how much progress is being made in understanding our biology! I recently heard about a study that showed certain dietary modifications could extend lifespan and I'm excited to see what other discoveries we uncover on this fascinating topic! 634 Reply 4 replies @suckeggs84 @suckeggs84 4 months ago 🎯 Key Takeaways for quick navigation: 00:30 📚 Dr. David Sinclair focuses on understanding why we age and how to slow or reverse the effects of aging through behavioral, nutritional, and drug interventions. 01:54 🎙️ Dr. David Sinclair is launching the "Lifespan" podcast, delving into the biology of aging and tools to intervene in the aging process. 10:11 💽 The aging process involves a loss of information in the epigenome, the system that controls which genes are switched on and off in cells, influencing their function and identity. 17:28 📈 The biological clock (Horvath's clock) shows that there is a period of accelerated aging during the first few years of life, followed by linear aging for the rest of one's life. 19:26 🔍 Accelerated aging can be caused by DNA damage, broken chromosomes, and massive cell damage or stress. Understanding and controlling these factors can influence the aging process. 21:27 🍽️ Fasting and low growth hormone levels have been linked to longer, healthier lives in animals and humans. 23:23 🏋️‍♀️ Epigenetic changes can be influenced by lifestyle, allowing individuals to have a significant impact on their longevity. 26:18 🥦 Intermittent fasting and avoiding constant food intake activate longevity genes (sirtuins) and down-regulate mTOR, leading to numerous health benefits. 27:43 🔬 Hunger itself may have some beneficial effects on longevity, beyond just low blood glucose and insulin levels. 31:14 🍽️ Personalized approaches to diet and fasting, as well as adjusting meal timing, can be effective in promoting longevity and overall health. 43:33 🍷 Resveratrol, a compound found in red wine, can extend the lifespan of mice when taken every other day on a normal diet. 45:00 🏋️‍♂️ Metformin, a drug for type 2 diabetes, may increase longevity and reduce the risk of diseases like cancer, heart disease, and dementia. 49:00 🌿 Berberine, a compound found in plants, may have similar benefits to Metformin and can increase insulin sensitivity. 51:26 🍇 Pure resveratrol supplements (light gray or white in color) are recommended as red wine alone won't provide enough resveratrol for its beneficial effects. 57:25 🧪 NMN and NR are NAD precursors that can help boost sirtuin activity and potentially slow aging when taken as supplements. NMN is more effective in increasing NAD levels compared to NR. 01:04:13 💊 Look for NMN supplements from well-established companies with high levels of quality control (GMP). 01:05:14 ⏰ Take NMN and resveratrol together in the morning, as NAD levels in the body naturally increase during this time. 01:07:41 🏃‍♂️ Some athletes claim increased endurance and performance with NMN supplementation. 01:09:38 🚫 Artificial sweeteners might have small effects on pro-longevity pathways but are generally not a major concern. 01:13:08 ⚠️ Excess iron intake may accelerate aging due to increased accumulation of senescent cells. Personalized medicine and optimal ranges for health should be considered. 01:24:58 🍳 Dietary cholesterol has almost zero impact on blood cholesterol levels, so eggs and butter might not be as harmful as previously thought. 01:26:27 🌿 Plants offer high-density nutrition and xenohormetic molecules that can activate our own defenses against aging and improve health. 01:30:14 🍇 Antioxidants are beneficial in moderation, but turning on the body's natural defenses is more effective than supplementing with antioxidants. 01:35:10 🏋️‍♂️ Regular exercise, especially maintaining muscle mass, is crucial for hormone levels and overall health, including reversing age-related changes. 01:41:06 🔬 Scientific advancements, like manipulating transcription factors, show potential to reverse aging and restore function in cells, offering promising future prospects for anti-aging treatments. 01:45:36 💡 Home colon cancer tests are available, providing an alternative to colonoscopies for early detection. They are close to being as accurate as colonoscopies but cannot remove polyps like the latter. 01:47:09 💡 Challenging your body's thermoregulation, like sleeping cool and dressing lightly, may help burn more energy and potentially have positive effects on metabolism and obesity. 01:49:08 💡 Obesity may reduce NAD levels and accelerate aging due to the presence of senescent cells in fat tissue, which secrete inflammatory molecules. Inhibiting inflammation in the hypothalamus may extend lifespan. 01:55:40 💡 Overexposure to x-rays, such as dental x-rays, may be cumulative and potentially harmful. Limiting unnecessary exposure is recommended. 02:02:38 💡 Scientists' public education efforts are becoming increasingly important to provide trusted sources of information, especially when addressing complex health topics and countering misinformation. 02:05:42 📋 Dr. Sinclair aims to create a "credit score for the body" to help people track their health and predict future health and lifespan. 02:06:10 📊 He has developed a biological age test, a simple mouth swab, to measure biological age, and plans to make it affordable and accessible to everyone. 02:06:39 🎉 People who manage to reverse their biological age will receive a "negative birthday card" from Dr. Sinclair to celebrate their progress. 02:08:07 🧠 Dr. Sinclair discusses mechanisms, global protocols, and individualized approaches for improving health and extending lifespan. 02:09:04 📚 The Lifespan podcast featuring Dr. David Sinclair will launch on January 5th, offering valuable insights into aging and how to slow and reverse it. Made with HARPA AI 50 Reply 5 replies @brandonbarnes6493 @brandonbarnes6493 2 months ago Why I love Dr. Sinclair. He always answers so honestly. “We don’t know, but I’ll give you my best answer.” I appreciate you both for taking the time to educate us! 24 Reply 1 reply @TREEfool @TREEfool 2 months ago This was an absolute goldmine of knowledge. Thank you guys so much for sharing. 8 Reply @mss_tanja @mss_tanja 3 months ago Dr. Huberman is really creating an amazing legacy of information. The only problem I have with him is that I get lost in those eyes and forget to listen. 29 Reply 5 replies @kcmaxwell1509 @kcmaxwell1509 1 year ago My father is 97 years old. He is a WWII vet and has survived double pneumonia, sepsis and Covid in the last two years. And he rides his recumbent bicycle 30 minutes daily. His longevity, in my opinion, is directly related to his low caloric intake (and great caretaking). He’s eaten once or twice per day for his entire life. Super interesting science. Thank you. 1.6K Reply 84 replies @Jbsa1998 @Jbsa1998 7 months ago I felt like I was sitting in on a lecture and I was engaged the whole time! Super informative and insightful! Thank you so much! 16 Reply @jonahalldors5488 @jonahalldors5488 2 months ago Thank you both for a fantastic podcast, I can’t thank you enough for your great work and for sharing this with us ❤ 6 Reply @cyndijoylee @cyndijoylee 10 months ago This was so very awesome. I’ve watched both of you on other podcast and I’ve learned so much. Thank you so much for the work you are doing and for the lives you are saving and changing. 4 Reply @lizzie4469 @lizzie4469 10 months ago David Sinclair; the guy who promotes NMN whilst working in a company that has now essentially had it banned as a supplement in the UK! Great guy, a shame that Andrew hasn’t picked up on this! 10 Reply 2 replies @abdulsattarali8220 @abdulsattarali8220 10 months ago Truly what these incredible human beings are doing is amazing. People should follow their findings and listen to their advise and try to live healthy life and keep helping others. Together we need to spread this information as much as possible. 5 Reply @akashprathod @akashprathod 1 year ago Two scientists that I follow all the time, now on one podcast. This is a Christmas gift. 1.6K Andrew Huberman Reply 28 replies @Susan-L193 @Susan-L193 3 months ago I freaking love this conversation! Wow, the iron levels. When I was pregnant with my first child I was advised strongly by my doctor to take iron. I did so, and when my daughter was born, I could smell the iron in her/our blood! That frightened me and have only ever taken it in moderation and rarely since then. Fast forward two years, the same daughter was pale in skin tone as she inherited her father's celtic skin, and a different doctor was concerned but at least didn't go hard on advising supplements and I knew her diet was good. Fast forward a few decades and when I started donating blood, noticed my iron level was lower each time I donated, so I limited my donations to annually despite being told that it is 'safe' to do this every 6 weeks. It is so refreshing to hear the science with acknowledgements that everyone is different, as is our upbringing. 4 Reply @bio_vet @bio_vet 1 month ago That was a mindblow. What a conversation to shake everything we heard before about diets and health. Thank you for doing this podcast! 3 Reply @kathyannk @kathyannk 9 months ago (edited) Dr. Sinclair looks easily twenty years younger than his chronological age. He obviously knows what he’s doing. Thank you both for an interesting conversation. 14 Reply @gabrielledavis7491 @gabrielledavis7491 9 months ago Thank you SO MUCH to both of you for allowing us to listen to this spectacularly insightful conversation. Us viewers are sincerely appreciative. 3 Reply @amalsoliman7072 @amalsoliman7072 10 months ago Thank you so much for such an amazing & inspiring episode where our future is wisely speaking to us to change our lifestyle routines into more healthy ones:) 3 Reply @jaynanewbold8263 @jaynanewbold8263 1 year ago In addition to the generosity and vast knowledge provided, can we all agree that this podcast is most enjoyable due to the fact that these two gentlemen utilize the art of conversation very well? No interrupting, grandstanding, one upmanship, talking over one another. A lost art, indeed. Well-directed by Dr .Huberman and cooperative responses by Dr. Sinclair. Riveting!! Thank you both! 282 Reply 13 replies @KipIngram @KipIngram 8 months ago Absolutely LOVE how Dr. Huberman handles this - he carefully brings out all the right things. Fantastic interview! 3 Reply @melinadimitriadis1615 @melinadimitriadis1615 10 months ago Hey Dr H & S. Amazing podcast. Thank you so much. I was wondering if you would recommend the same for pregnant or breastfeeding females? Also I would love love love a podcast on the right nutrition for young kids (2-10 perhaps). With no nuts in school and picky taste I often worry about my child’s overall nutrition. I definitely give her a multi vitamin so when I heard you and Dr. Sinclair talk about multi-vitamins I was like “oh F. That was my back up to make sure my daughter gets everything she needs”. Anyway. Would love some content around kids, pregnant women and breast feeding women if you have an expert in these area’s in relation to fasting and diet. Thanks so much. 3 Reply @chrissienewtosupps7733 @chrissienewtosupps7733 3 months ago Again another information packed interesting interview.. both you Andrew And David are incredibly knowledgeable... extremely enjoy listening to the depth you went to... thankyou for sharing your incredible work :) 2 Reply @avinashrockstar @avinashrockstar 4 months ago Great job Huber🎉 All your videos should get language subtitles for most of the used languages so that it reaches all over the world. 4 Reply @karenvantuyl901 @karenvantuyl901 3 months ago What an Amazing pod cast 🎉 Im grateful for the information from scholars in the fields. 2 Reply @vickihughes9476 @vickihughes9476 11 months ago I am a practicing physician assistant and went into medicine because my family has always been on the wholistic/ natural path. We grew our own veggies, bought farm fresh eggs and grass fed local beef, had fruit trees and grape arbors. We ate fruits and veggies all day. We were physically active all day. My father is 93 and not on any meds. My mom is 89. They do not smoke and rarely drink alcohol. They have never had cancer, diabetes, dementia, heart disease. I have been telling patients for years that it is not rocket science and the best treatment I can give them is to eat only to live and keep moving. I could talk for hours about this! Our food production and lifestyles are killing us. It is that simple!! I would love to help get more of this information out there! And I would love to meet you both! Thank you and Keep up the great work! 419 Reply 19 replies @MB-my5kc @MB-my5kc 5 months ago Thank you both for this most informative share. Health is wealth and knowing how to achieve that is key. Thank you for your transparency, so very refreshing! Reply @vegaelmasbuscado @vegaelmasbuscado 10 months ago (edited) They should make a documentary about this with animations and everything, it just sounds fascinating to see how far this has come to from a microcosm perspective making an impact to our lives. I wonder if people that started working out in their late 60s like Takishima Mika now in her 90s and now fitness instructor had that genome sort of awakening by just changing into a healthy lifestyle.I wonder if she kind of rewrote her cd sort of speak. genetically speaking. 3 Reply @alisontomsett5248 @alisontomsett5248 3 weeks ago Angina completely gone since taking reservatrol and NMN. Also doing intermittent fasting. Amazing info thank you. Life changing literally. 2 Reply @vka82055 @vka82055 9 months ago Very excited about these facts we can apply to our lives instantly with amazing results❣ Many thanks to you and David Sinclair! 2 Reply @luiscrespo9902 @luiscrespo9902 4 months ago Awesome interview, Andrew! Your detailed questioning was superb! 4 Reply @hariprasanth2727 @hariprasanth2727 1 year ago This was the collab I was eagerly waiting for. I am a researcher in robotics and I am very excited to learn about a topic that is completely out of my research interest all because of you how interesting you guys made this. Thanks for all this work 92 Andrew Huberman Reply @franciscochacon5542 @franciscochacon5542 2 weeks ago Thank Andrew and David. This is the best video I've ever seen about aging so far. Thank you for sharing all the good knowledge 💯 Reply @user-cc1gp9jg4v @user-cc1gp9jg4v 4 months ago Very difficult subject, but a great episode, thank you Andrew. I think it would be very useful if you made a series of episodes explaining each pathway in the brain and body, what it does etc, and also how it is affected by the various chemicals. I think it will help us understand deeper the issues that you explain. Nevertheless, great work keep up, and I personally want to thank you a lot for your contribution to the evolvement of my thinking. <3 1 Reply @anyaturker412 @anyaturker412 8 months ago Brilliant ! ❤❤❤ so very impressive to hear about your great grand parents winning the NOBEL PRIZE with critical periods (The apple does not fall far from the tree). Can you PLEASE do a podcast specifically how to reopen critical periods even if briefly due to infants getting ill during a critical period and having long term developmental issues ? PLEASE? This would be incredibly helpful. THANK YOU SO MUCH for sharing all this information with the public, truly brilliant ! 4 Reply @carolfairfieldmua9040 @carolfairfieldmua9040 8 months ago Currently watching this. Only recently discovered Dr David Sincalir and Huberman this morning. An absolute pleasure to listen to these 2 gentlemen. I'm defo going down this rabbit hole lol 3 Reply @shay5025 @shay5025 8 months ago (edited) I took resveratrol because of his research in the 2000s in my early 30s. I had a critically bad response and all of my tendons became really weak and I had massive onset of what felt like arthritis throughout my body. I was on the Imminst/Longecity forums back then and there was a subset of people on resveratrol who had very bad tendon responses. Sometimes they would just get up out of their chair and rip their Achilles tendons. Never touched resveratrol since then and it took years to recover, and I don't think I ever fully did. 10 Reply 4 replies @Nightowl1947 @Nightowl1947 1 year ago What a gift for us, your audience. I do the fasting at 74 and feel great. Implementing new ways to maintain good health, never felt so good! Thank you both for you kindness and willingness to share . 133 Reply 1 reply @alritchie25 @alritchie25 9 months ago This was a fabulous interview! I learned so much ❤ Reply @adrianbalteanu6095 @adrianbalteanu6095 3 weeks ago Andrew, fantastic job! You've placed all the right questions in order to complete the image of what Dr. David's explained, great work! Reply @mohamadhasanansarizadeh7420 @mohamadhasanansarizadeh7420 1 month ago Super informative, I really enjoyed it as a researcher in the biotech field. this is perfect to share such videos and making them viral instead of superficial medical suggestion on social media 1 Reply @annap214 @annap214 3 months ago People really thirst for this type of information!~ thank you for sharing all the amazing and extremely useful information in this channel ❤ 4 Reply @susanhenley8844 @susanhenley8844 8 months ago I am so happy to have stumbled upon this podcast and will be listening to more. Thank you! 6 Reply @xxlegitfailxx @xxlegitfailxx 1 year ago Was on the borderline of checking myself into drug treatment this month until i started reading Why We Sleep by Matthew Walker, watched a few of the podcasts in this series followed by a responsible psychedelic experience...can't explain how grateful I am for resources like yours, Dr Wakers, Dr Sinclairs etc. People don't talk enough about how diet, exercise and proper rest enable making the right decisions in other areas of your life so much easier. Normally i shitpost and troll in the comments but with 100% of my sincere-ness thank you. 241 Reply 15 replies @tijen_ @tijen_ 8 months ago My father lived to be 90 years old; my mother is a healthy 93 year old. In my opinion, their longevity is based on good genes, a healthy vegetable heavy; meat light diet and, a physically active and social life style. We have a citrus orchard & they ate a lot of citrus fruits. Perhaps, vitamin C can take some credit too. Most of their senior years they lived in a Blue Zone, south-western corner of Turkiye where the seas Aegean and Mediterranean meet. There are four seasons and only summers are hot. I have been told by a doctor that continuously living in a hot climate tends to result in shorter life spans. 6 Reply @germandaria @germandaria 9 months ago The best what I like about how Andrew is handling an interview is that he really does not interrupt. In this case its even more important than saying things. 7 Reply @deniseunknown4576 @deniseunknown4576 7 months ago (edited) I could listen to Dr. Sinclair for eternity. Great interview. I rarely stick around for 30 minutes much less 2 hours. So great job Andrew & David. Thank you for such amazing information. Enlightening to those of us that aren’t on that biological level of information. Eye opening. Truly appreciated. 4 Reply 2 replies @jayebejer7431 @jayebejer7431 9 months ago Yo, Andrew.. thank you, your insights have helped me in my life immensely, with my addictions and behaviors and family relationships, I cannot thank you enough for the hard work you do and these free podcasts (or whatever this is) .. everyone donate some $$ to Mr Andrew. He works hard to benefit those seeking wisdom. I was playing Tony hawk and listening to rancid and pennywise and I couldn't help but think of this Rouge Neuro Genius. Love you man. 1 Reply @angelamontes9571 @angelamontes9571 9 months ago Love you guys , congratulations on this amazing program ! ❤ 2 Reply @rubyblu21 @rubyblu21 1 year ago I knew it was only a matter of time until Dr David Sinclair made his way onto your show. Thank you Andrew! 313 Andrew Huberman Reply 3 replies @johnburton9772 @johnburton9772 9 months ago Very informative! Useful, “actionable” trustworthy health information from scientists. 🙏🏻 1 Reply @danilomarch @danilomarch 10 months ago Excelent interview and explanation, well done both of you. 1 Reply @abhisheksinari1451 @abhisheksinari1451 10 months ago Hey Andrew...much love from India...love your work and I want to thank you for putting your best work. Been listening to your podcast for more than a year now and these topics sparks curiosity all the time. One small request is to put small clips as well for 5-7 min. It will be better to watch the video for smaller duration after listening to whole podcast. Cheer mate. All the best. Reply @supremecanine6848 @supremecanine6848 8 months ago Dr. Huberman, thanks for making the world a better and healthier place. 3 Reply @kathysandvoss5043 @kathysandvoss5043 6 months ago (edited) Love this. Learned so much. How does a person really not lose muscle with the fasting? Reply @AB-zq4fw @AB-zq4fw 1 year ago Thank you Dr. Sinclair and Dr. Huberman for all you've done and do! We appreciate you 🙏 78 Reply @Night17Man @Night17Man 8 months ago Once again , I really enjoyed it ! I follow both of you and I will continue. Very good when David Sinclair said « my doctor finds me very annoying »😄 1 Reply @georgeyung6185 @georgeyung6185 9 months ago Thank you for reminding us simplicity and paying attention to our nutrition, body changes, and supplementing. Also changing our habits. i like using these tools to gauge my aging and my husband’s. 1 Reply 1 reply @bonniekaliko8695 @bonniekaliko8695 9 months ago I’m a healthy 55-year-old female. I’m so fascinated with the science of longevity. Dr. Sinclair has a wealth of information and I am very happy to have come across this interview. I will say he may have changed my mind about taking bio identicals by equating it to a second puberty. I would also like to find a doctor to prescribe Metformin without a diagnosis of diabetes. 3 Reply @Sr-yo7cz @Sr-yo7cz 4 months ago Such an inspiring conversation. Thank you very much! Reply @nohandlerequired3607 @nohandlerequired3607 10 months ago Very interesting. I've always believed all this and most of my life I was living proof of this as very young looking and no illnesses, even now. I used to do alot of fasting and just a small eater most of my life. I once read those who eat lighter live longer. However, to my shock, at a certain age in 50 it all changed, suddenly, and suddenly had some wrinkles and a few gray hairs but my physical body gained wsight suddenly. This is normal for females at this age. I have to suggest it is true as I never suspected it would go down like that but it did, without warning and reason for it either. Besides age and hormone changes. Testerone controls weight and muscle mass and women by 50s have about 50% of the testerone they once have in their 20s. I don't care yet it was shocking as it was so sudden. It wasn't gradual. Maybe there is a reason, not sure what it is besides hormones. I don't care about age and getitng old. Aging gracefully. I'm glad the life I have lived, want to continue to be proud of this life and the compassion and empathy I lived the way of my life depsite what others can sometimes do or try to do to us. Living our life with our values is most important, not if we have wrinkles or get old. I still feel young and young at heart on the inside. Inner beauty is the most essential! 8 Reply @oliround @oliround 1 year ago This channel/show is a gift to mankind and we should be forever grateful to this man 129 Andrew Huberman Reply 2 replies @BloomByCC @BloomByCC 3 months ago 100% into following Sinclair's guidance on health. Brilliant. Reply @lisabeaumont @lisabeaumont 9 months ago Fascinating conversation - I'm presently working on optimising my own health and have taken notes. Thank you. :) Reply @EatingHormoneHappy @EatingHormoneHappy 9 months ago Hey! Love these videos. So I have a question and it would be amazing if anybody out there knows anything in regard to these issues. Two questions infact. The first is in relation to Gilberts syndrome. This is something that it’s not uncommon in people and it is an elevated level of Bilirubin in the blood. It results in a range of symptoms such as fatigue and jaundice. I have always been advised that if you have Gilbert syndrome that you should not fast as it will exacerbate your symptoms. I would love to know how it relates to this, and if there’s a way to benefit from fasting if you have Gilberts syndrome. My second question is in relation to female hormone health. So my research has also led me to understand that fasting tongue be quite bad for females to do because at different times and I cycle we have different dietary requirements. I would really love to know some more about this and if anybody has a view on this 1 Reply @lennertgainz @lennertgainz 5 months ago Sinclair seems like a smart guy who is not afraid to speak facts or offend anyone 👍 4 Reply @alisonmcintosh937 @alisonmcintosh937 1 month ago This was one of the most exciting things I've listened to in a long time. So interesting. Thank you both! Reply @laurenwinters6897 @laurenwinters6897 1 year ago What a difference it makes to have well practiced professors explain these ideas! This is such a gift. 75 Reply @gaellelebray @gaellelebray 10 months ago I am 47 soon to be 48… my Garmin tells me my fitness age is 39… I’d love to see from a biology perspective how accurate this is 😉 thank you for you fantastic insights 🙏 1 Reply @diornewlookgirl8061 @diornewlookgirl8061 9 months ago Very interesting. Actually I’ve been a health freak for so many years and struggled to always work out 7 days a week and eat so much vegetables every day for about …actually 32 years now. Actually I love it. It’s not a struggle except for it takes alot of time and effort. It worked so well. Up until I was 42 I looked 25. However. Last summer I went in the sun for a prolonged time during the day. I could feel the sun burn like fire that day. I was under a parasol but it was almost transparent it was so old. In just a day; deep lines formed under my eyes. I basically destroyed my face in one day. I am quite saddened by this, not gonna lie. Reply @ildiko-martasimon267 @ildiko-martasimon267 10 months ago Hi,this was an amazing and educational episode. Thank you so much for this. I would consider taking resveratrol,but I am afraid I will make the wrong choice.Which product is the best on the European market? Is there any specifics which can guarantee a good quality and not something harmful for your body? Thank you in advance! KR, Ildiko Reply @blissbrain @blissbrain 9 months ago (edited) This is such a great podcast! I wonder if eating at 9pm implies sleep is best undertaken at least 3 hours after finishing the last bite/sip? 1 Reply @lauralockie @lauralockie 1 year ago After viewing this podcast, I grabbed a copy of "Lifespan" by David Sinclair, and I was completely unprepared for what a well written, intriguing theory of life itself on our planet it would contain. Everyone should read this book to gain an understanding of the science of themselves and how to live a better life. Thank you so much for introducing us to his work! 148 Reply 17 replies @rosalindadehoyos5697 @rosalindadehoyos5697 2 months ago (edited) two of my favorite humans in one podcast, thanks for sharing this info guys!!! . Reply @Niceonthefrenchriviera @Niceonthefrenchriviera 9 months ago (edited) The video starts at 8:00 (for those who want to avoid the advertising and marketing) 😉 36 Reply @debbieamirault8745 @debbieamirault8745 6 months ago I’d love to see a podcast specifically on osteoporosis, bone health, and the treatments for it. There is such mixed information about what prevents or reverses osteoporosis, the effects of physical activity and what types of activity, vibration therapy, supplements, nutrition and prescription medications, physical therapy vs chiropractic care, bracing, etc etc. This disease will affect many of us as we age and can be quite debilitating and a risk for death in the case of broken hips for older folks. 5 Reply @kathy8389 @kathy8389 4 months ago Wow, even from the first question posed by Huberman and then Sinclair's answer to that, it's a paradigm shift. Now, will continue listening to the rest of the podcast. Reply @katewenzell @katewenzell 1 year ago One thing I question is the exposure to cold. I was homeless for 6 years and it wrecked my health. I have to say right here that I don't do drugs, that was never my problem, because a lot of people on the streets self-medicate, but I never liked drugs, not even pot. The main contributing factors for my health deterioration were were chronic stress (bordering on PTSD), especially due to constant police and societal harassment, and poor diet, due to being poor, eating old, cold and cheap foods. However, one other thing started really messing my hormones up, and that was living through winters and snow without heating. I lived in my van, so I would get under the feather comforter and sleeping bag at night and shiver for about an hour until my own body heat would heat up the space. I was able to get warm during the days at a cafe or library, but there was no refuge at night from the cold. The last couple winters, my body started having trouble self-regulating its heat. I would be so cold, and then I would suddenly overheat and be sweating. I have gone into early menopause in my early 40's. I am totally traumatized by the cold now. I feel like Scarlet O'Hara in "Gone With the Wind," except I would say, "As God is my witness, I will never go cold again!" Dr. Sinclair saying he wears a T-shirt in winter gives me shivers. So I respect deprivation of our ancestors (and the current indigent) as something that can be absolutely damaging. The homeless have a much lower lifespan than the rest of society. Controlled deprivation is still privileged deprivation. That being said, we do live in a society of sickening over-abundance. And I do notice that wealthier people often seem less happy than the homeless, where the smallest thing is appreciated. I watched your video on dopamine, and it finally made sense to me why that is. Now that I am housed, I am able to rest and heal and have some peace, but I'm also in a slump. Being alive in this world is a difficult balance between security and thrill. 631 Reply 137 replies @nebojsa973 @nebojsa973 3 months ago Dear Sir, on the topic of cholesterol, I believe t would be very good if you would bring Dr Robert H. Lusting to discuss the topic. His work has been really amazing and, from personal experience, it changed my life for the better as much as your did. Thank you. Reply @rainruns2708 @rainruns2708 10 months ago Thank you for this free educational video! It adds value to my life 1 Reply @ursulahutmacher2707 @ursulahutmacher2707 2 months ago Very interesting pod cast! I wonder, if Dr. Sinclair has taken the blood theory by Dr. Peter J. D'Adamo into consideration in regards to his diet. It works very well for me. What you both said about meat, makes me believe you could both have blood group O. Reply @MrZendude @MrZendude 10 months ago This is absolutely brilliant information! Is there anything on hair regrowth that can be triggered because of anti-ageing supplements? 3 Reply @marikacartwright2548 @marikacartwright2548 2 weeks ago I love you guys for educating us amazing ,l follow you both ,from this podcast l have some idea how l ought to use my supplements, thank you so much ,l have forwarded this to my clients ,friends ,family .Marika Australia Reply @jessikalove4788 @jessikalove4788 1 year ago I feel like Professor Huberman is my friend on the inside at this point, lol. I look forward to these weekly podcasts. Such a wealth of information. Also, he seems to have such a positive aura. Keep up the great work, Professor! ♥️ 128 Reply 7 replies @mymadness2010 @mymadness2010 3 months ago Thank you Dr. Huberman for this podcast, I have a question about Resveratrol. Taking it causes a shoot in my BP and makes me weak and just can't function during the day. Is there any reason for this? How can I benefit from it without this side effect? Reply @davidedados5405 @davidedados5405 3 months ago Hi Dr Huberman, a question if possible: I have just discovered your channel, in your opinion is it possible to counteract the process of hair colour loss and pigmentation of one's natural pigment? Is there any protocol to date to counteract such loss? Reply @rosebuddloved @rosebuddloved 1 month ago Excellent interview!! Thank you ❤ Reply @bitsbard @bitsbard 1 month ago You're reading some supreme content. I've perused a book on this topic that was equally gratifying. "Adapting with Aging" by James Crescent Reply @julianosanm @julianosanm 6 months ago (edited) "That's why you're such a great scientist" You two get a room already! 😂 I'm kidding this episode is one of the best. It feels like the year is 2123. Thank you so much! 1 Reply @lotfibouhedjeur @lotfibouhedjeur 1 year ago (edited) Both of my favorite professors get together! This was so exciting I could listen to them all day. I love how they treat anyone who gets close enough as a potential science experiment 😂 Thank you both for making this happen. 27 Reply @aminakhan4199 @aminakhan4199 9 months ago Very informative, thanks for sharing this incredible information. Also wondering what device Dr Sinclair mentioned to measure biological age ( 1:56) Reply @NicoleBL2 @NicoleBL2 7 months ago This is such a wonderful, important, useful video! Thank you Reply @veryannoyingname @veryannoyingname 4 months ago Thank you for an amazing discussion. Re listened couple of times! Reply @eferrie2167 @eferrie2167 4 months ago What an incredibly informative conversation Reply @cindyd.5507 @cindyd.5507 9 months ago One of my clients just passed at 102 she had a very clear mind no problems with memory she ate everything in moderation she was never heavy over the course of her life she did enjoy a sweet treat from time to time. My mother-in-law just turned 93 she is in good health worked until she was 80 and ate everything she was heavier when she was younger but is smaller stature as she aging . I do think sometimes living a long life is luck that you were born with good genes but taking care of yourself helps being natural not having surgeries to change ones appearance unless it interferes with vision and not obsessing with becoming younger it is natural to age we do not live forever, We are organic like a piece of fruit that ripens only it takes a little longer for us but it is the inevitable. Will all these supplements keep you from aging? No .Will you live a longer life as a result? 3 Reply 1 reply @Borromeo377 @Borromeo377 1 year ago My two favourite scientists who I deeply admire 🙌🏼 Thank you Andrew for bringing David to your podcast 🙏🏼 I am grateful to both of you for sharing your precious knowledge and experience with us ❤️❤️❤️ 15 Reply @KKragh @KKragh 5 months ago Would love an updated conversation soon that includes some of the results of the research being discussed! Reply @eonoeeonoe7647 @eonoeeonoe7647 9 months ago this is very interesting.. so many things unheard of. i hope these 2 scientists collaborate. thank you for sharing this to us. Reply @liameneuk @liameneuk 9 months ago I just watched another video from Dr. Sinclair released 8 years ago and it seems that his was actually younger in this one released one year ago. I wish he could disclose whether he used any "artificial method" other than mere improving diet, exercising and taking supplement cocktails. If these 3 are all he has been doing to achieve this, then it would be amazing. 1 Reply @michaelwellner8151 @michaelwellner8151 9 months ago Thank you, gentlemen for such forward thinking about humanity moving forward in being healthy Reply @andreak.6752 @andreak.6752 7 months ago Very informative! I live a pretty active life, I intermittent fast every day, as well as eat a high protein diet & drink alot of water. I'm also almost 40 years old. 🦋 1 Reply @YananoBere @YananoBere 1 year ago I love how sensitive you both are to people's mental health. So many doctors are alarmist and turn people into hypochondriacs 17 Reply @agatasla5925 @agatasla5925 5 months ago Thank you for your passion for sharing knowledge! Reply @user-kd5lx6rm5t @user-kd5lx6rm5t 1 month ago You are a visionary - more power to you! Reply @ioncorbu4947 @ioncorbu4947 8 months ago This is extremely informative. Well explained so basically everyone can understand. If I may ask what's your view on dr. Sinclair's study concluding that low intermittent doses resveratrol is more effective for longevity, vs high dose that is more effective against mortality rate. And why dr Sinclair take 1g of resveratrol daily, which is a very high dose? Reply @dinezeazy @dinezeazy 8 months ago Damn !! I have read this Book Lifespan during my lockdown days!! Good to see him here. I was already doing 16-8 fasting back then. Reply @gabriela2946 @gabriela2946 9 months ago I am still not quite sure which age is appropriate for supplements like these. Because I am pretty young (21years old) and I would love to know more about the age you should or it’s okay to start taking supplements ( considering you’ve done all the other essential parts of the process). Could you provide more info about stopping aging from young age perspective? 2 Reply @highdeepak @highdeepak 1 year ago Going to buy the book. Insane podcast. I didn't take him seriously until I knew he was 52. 314 Reply 31 replies @filomelavarisco8183 @filomelavarisco8183 8 months ago So interesting! I could listen to David Sinclair all day long 1 Reply @One.-- @One.-- 6 months ago (edited) Dr. Outstanding work. Wish I could return back to 5 years old & had parents or a 😮parent like yourself & could of started a whole new perspective on life, & intake of food. The quality & geographic ground the food is from is 😂 very importants as opposed to soil types or grow your own, pesticides, chemicals genetically engineered as we know are killing us. The saying is you are what you eat & add excersise, sleep, fast, & most of all as what the good Dr has done is what you learn & put into your brain. Good Stuff Bravo 1 Reply @Epp638 @Epp638 8 months ago About the whole warrior diet theme: research almost completely points in the direction that we as humans are diurnal eaters. Would love Oris stand on that. Great podcast as usual! Reply @gregoryjones9829 @gregoryjones9829 10 months ago Two brilliant minds working to make are life's better if we're willing to listen thank you for sharing your knowledge Reply @BudoReflex @BudoReflex 5 months ago (edited) Considering Dr Sinclair could pass for the average 25 year old in Australia, I just took a page of notes on this interview. 1 Reply @anonona1 @anonona1 1 year ago I just watched the "best gratitude practices" episode, where he shows one of the best ways to practice gratitude is to replay a story of someone being genuinely grateful to someone else, and here Andrew himself provides us with that story, such a heartfelt moment. Thank you both for all you've done. 44 Reply @SorayasFierceCookingShow @SorayasFierceCookingShow 10 months ago Amazing information. Thank you both! Reply @rosaarega4416 @rosaarega4416 4 months ago This video is so good ❤ thank you you two guys Reply @alamore5084 @alamore5084 6 months ago Every word of this chimes with me and much of it validated based on my personal experiences. In my 40's I have discovered 2 meals a day and not 3 are better. I excercise with cross training every day. I feel happier and prefer the burn of being always on the hungry side. Versus the old porcine me with bulging stomach always feeling too full. Sugar is the work of the devil also. Why they have to pack seemingly everything with sugar is beyond me. 1 Reply @andreaslynen6113 @andreaslynen6113 9 months ago So great. Dr. Sinclair and you changed my live. I read his book. Great interview. Thanks so much🙏🙏🙏 1 Reply @Prof_Loredana @Prof_Loredana 4 months ago My great-grandma died at the age of 96. She was fasting 2 days a week, was vegan 2 -3 days a week (and full vegan 40 days before xmas and Easter) and she would fast 72h during the high holidays. She was also very very petite (less than 150cm), would pray 3 times a day and raised a family of over 40 offsprings (she was a war widow with 7 kids who each had 4-6 kids). Is interesting that fasting and height was mentioned in this video... Reply @dannypiper383 @dannypiper383 1 year ago Time flew by while I watched this 2 hours and 10-minute video; it was equivalent to watching a great movie. It's refreshing to see the dialog and hear unfiltered information directly from the source instead of through an intermediator. A wide array of subject matter was extrapolated from this podcast. Well done! 13 Reply @Smalltime89 @Smalltime89 9 months ago GREAT SHOW. Can you please at some point speak to the loss of bladder control in over adults . Thank you sincerely for the work that you do. I am over 50 with a wife and a 5yr old daughter at home. By the grace of God I hope to be alive and healthy for a long time :). 1 Reply @henrietadale5079 @henrietadale5079 7 months ago Professor Huberman could play Zeus in the movies! Amazing interview as always. Thank you doctors 🙏🏻♥️ 4 Reply @mikeramgopal3912 @mikeramgopal3912 4 months ago Thank you Andrew Huberman for another very informative interview. Lots of good info, although very surprised on his take on LDL and statins, when there is so much evidence to the contrary....... Reply @thefinancesplan @thefinancesplan 3 months ago 🧬🕰 Crack the code of timeless living with Dr. David Sinclair on the Huberman Lab Podcast #52! From unraveling the mysteries of aging to unlocking the potential of longevity, this episode is a treasure trove of scientific wonders. Get ready to rewrite the chapters of time! ⏳✨ 1 Reply @alexandrelevesquemtl @alexandrelevesquemtl 9 months ago Wow!!! Such a great interview! Great job interviewing a great guest! Reply @jonathandaniels5825 @jonathandaniels5825 1 year ago This was the best interview of Dr. Sinclair and I've seen a lot of these interviews over the years. Too many times interviewers ask Dr. Sinclair questions that his book or prior podcasts answer. You asked some to unassumingly baseline an understanding and go further to ask questions I would have asked (e.g., dietary cholesterol, iron, finer protocol practices, etc). We got answers we hadn't heard before. Nicely done! 24 Reply @ckuttzolt @ckuttzolt 5 months ago I’m about 10 episodes in and am enamored by the science. Just finished Reversing Aging and am excited about what I’ve learned. My mother is 97 and fairly robust. Can I make it to 110? 120? Now I just need to figure out how to afford to live that long! 😉 Btw, I also have a huge teacher crush on you. I’m 68 years old and wondering if I can make myself 20 years younger utilizing science and these techniques, if you’d date me… 🤔 😂 Reply @roljicb @roljicb 9 months ago Thank you Andrew for all informations! I will try to do so as much as posible. I wish to look young as Dr.Sinclair who is 52!!! Awesome! 1 Reply @tippyzuk1 @tippyzuk1 2 months ago Great questions and answers, learned so much Reply @AggieBuilder08 @AggieBuilder08 1 month ago Modern medicine always amazes me. Hope I’m around to see the days of regenerative cell breakthroughs. Reply @JiuJitsuMasterCaique @JiuJitsuMasterCaique 10 months ago My own experience with cholesterol is that oatmeal definitely helps to low the numbers. Just eat it every day. I do and my numbers went down from 220 to 190 in 4 months. 1 Reply @segfahlt @segfahlt 1 year ago This was a phenomenal discussion. Thank you both for your time, your knowledge, and your dream to bring your knowledge to the masses. 33 Reply @atsaivan @atsaivan 3 months ago (edited) Thanks! Really good content as ussual! Any guidance on how to choose an NMN, Resveratrol, etc.? 1 Reply @beldir1701 @beldir1701 7 months ago Both really thank you, 🙏🙏🙏they explained many things clearly and now I am thinking to question everything👍 Reply @markjohnson8642 @markjohnson8642 2 days ago Dr Sinclair, after an accident in which I lost half my blood volume I developed (suddenly) bilateral NAION. This was March 2023. I'd be interested in participating in a study if applicable to my case. Reply @ashleygeorge8520 @ashleygeorge8520 8 months ago One of my favorite episodes. " We are drowning in information and half of its false." Reply @m.talmagemoorehead @m.talmagemoorehead 9 months ago Andrew, Thanks for interviewing David Sinclair. Respectfully, I wish you wouldn't interrupt him so often during the interview. Thanks. You're doing great work. Keep it going, Andrew. Reply @stevegreen65 @stevegreen65 1 year ago I love Dave. He is such a smart guy, has a great sense of humor and he is able to break down complicated subjects in easy to understand pieces. 26 Reply @wboyle9721 @wboyle9721 4 months ago One of the best channels on you tube full of great science information plus it is free to watch 1 Reply @mandyb2000 @mandyb2000 9 months ago Really good podcast, I've followed Dr Sinclair for decades, same lifestyle choices as he chosen, I'm 44...pple think I am 25, I trust his advice completely, his intelligence continues to amaze me!! 1 Reply 2 replies @saidfarid6382 @saidfarid6382 8 months ago Hello Professor and Doctor. Thank you so much for your interesting information about Health, i do appreciate your job. I wish you peace and happness under the sky of prosperity. All the best. Take care and have a good time. Your Student from Algeria. Reply @keyomikothari @keyomikothari 10 months ago 2 god's and best minds together! What a wonderful podcast episode!! Thank u! Reply @KARATEbyJesse @KARATEbyJesse 1 year ago Happy new year Dr. Andrew! 🥳Thanks for the life-changing lessons in 2021 🙏 Can’t wait to see what you have in store for 2022 🌟 61 Reply @jeffseymour8908 @jeffseymour8908 2 months ago I have been doing the protocol of Sinclair for a couple years and have seen my InsideTracker show my age drop to the point where it is now 10years less than my chronologic age (48 instead of 58). For the next few months I have stopped this longevity regimen to build muscle. I'll switch to a balance of both afterwards. My question is this: if I were to now reintroduce the longevity regimen: fasting, resveratrol, metformin, NMN-> will this materially reduce my ability to continue to grow muscle? It seems like these processes are in opposition. thanks Reply @brandonrice9650 @brandonrice9650 6 months ago Watching the video I started the 3 X nose breathing and 4th ,doing the test right away . Life long battle with Asthma. 82 seconds 20min out of bed. I know I could probably hit 100 with a day of practice. Reply @avidal754 @avidal754 4 months ago Incredible podcast! Reply @lendalennuk2484 @lendalennuk2484 10 months ago Thank you! Integrity of a true science is illuminating and empowering. Reply @catherinemumbi8191 @catherinemumbi8191 1 month ago Awesome invaluable information!!! Thank you Reply @mashantha @mashantha 1 year ago What a brilliant podcast! In absolute awe - extremely grateful to you both for your service to humanity and your commitment to educating the public! loved this. 77 Reply 1 reply @gericrouch4234 @gericrouch4234 10 months ago This was so interesting. I'm honored to be a part. Reply @gstudio33 @gstudio33 3 months ago Andrew, I'm 30 years older than you, wow. I have no arthritis, no joint problems. But, I have been a type 1 diabetic for 40 years. It's been a struggle at times. I get challenged at times about my age. Reply @deedsterskater3011 @deedsterskater3011 4 months ago So much good info. Also a bit obsessive. My sister and I started shopping in health food stores when they were all run by Seventh Day Adventists. We take no pharmaceuticals. I don't go to doctors. No insurance save my last year in college.. It wasn't worth it! We both look much younger than our years. We do lots of things to maintain great health. But, it helps to have good genes. Reply @jordanong5114 @jordanong5114 4 months ago Thanks for interviewing him. I may want to be his student one day. Reply @SilverFan21k @SilverFan21k 10 months ago Thanks for having David on! 1 Reply @Darnabymom @Darnabymom 1 year ago I just turned 60 and am the caregiver for my mom who this week turns 100!!!! For her age she is doing amazingly well. As I see her quality of health, it spurs me on to increase my health span not just my life span. 78 Reply 6 replies @DaddyEZ545 @DaddyEZ545 8 months ago ❤thank you so much for both of your helpful important information thank you 🙏 Reply @mordie31 @mordie31 3 weeks ago I had a friend when I was younger who was bulimic and really skinny. Her cholesterol was through the roof! It was ridiculous that her doctor was telling her to eat less fatty foods . Reply @MasterBrain182 @MasterBrain182 2 months ago Thank you Dr. Andrew 🔥🔥🔥 1 Reply @davidhoover2446 @davidhoover2446 6 months ago Something no one talks about is indoor air quality. The last 100 years we have built more and more air tight homes. High C02, VOC’s, and particulates are causing short and long term health conditions. I was one of them. We had to add ventilation to our home because I couldn’t sleep due to discomfort. Once we did that, I can now sleep well and I feel much better overall! It plays a big part in how we feel. But, you can’t see it so no one cares. But, we breathe 40lbs of air per day. 1 Reply @susanstultzhauss132 @susanstultzhauss132 1 year ago Dr Huberman and Dr Sinclair. Thank you so much for sharing your passion and knowledge, for free, with us!! It is very frustrating that a lot of sources want you to buy their book first or pay for the "secrets". I loved this podcast!! 32 Reply @allyjoy5943 @allyjoy5943 10 months ago Incredible information. Thank you. Reply @fabiodias5958 @fabiodias5958 2 weeks ago “It’s full of stevia “ you guys are awesome 👏🏻 Reply @ShugarFuk @ShugarFuk 3 weeks ago First, I'm not a vegan, but I lean heavily on plants and I, too, come from a family of heart disease. I'm 63 and my father made it to 48 and my brother made it to 49. When I was 40 a lab technician noted significant signs of atherosclerosis while reviewing a scan of my lower back. A CT angiogram in my mid-50s showed no signs and that was after 3 years of strict plant-based eating in which I tracked my own lipids. Indeed, cholesterol studies are a mess, and this likely has something to do with the billions. of dollars in profits related to cholesterol-based foods. I can promise you that my serum cholesterol is dramatically influenced by cholesterol in my diet, and if a study doesn't start with a vegan or those that consume little to no cholesterol, then I would ignore their results. I also do not know the landscape of research in this area; however, I do know of at least one study on eggs that started with a group of Americans who were already consuming a lot of cholesterol. In that case, adding eggs--astonishingly ; ) --had no impact on serum cholesterol. "Amazing! Let us eat eggs!" it was funded by the egg industry or those with a vested interest in profits from the sale of eggs. The test is easy. Live without cholesterol for a month, get your lipids, then go back to a diet full of cholesterol and check it again. We don't need studies to prove this. And we don't need animal foods for amino acids: we need plants for the essential amino acids, which we can get from the animal that ate the animal that ate the plants, or we can get them from the plants directly. Heart disease is a choice for the vast majority of people, and I'm choosing to not have it. Reply @adilkarabagl5792 @adilkarabagl5792 9 months ago Hello there, and thank you for all the amazing content. Are these supplements Resveratrol and Nmn safe for people who has a long cancer history? Reply @ZeepXanf1orp @ZeepXanf1orp 2 months ago Can we please get ATTIA, SINCLAIR and GALPIN in the same room together to parse out a fitness regimen specifically geared to garner every longevity& immediate health adaptation that is possible from the various exercise strategies? 1 Reply @Livingwithadog @Livingwithadog 1 year ago Imagine how the internet has changed the world. You can now easily prolong your life for free because of technology and intelligent people like Andrew 761 Reply 30 replies @markgoals7519 @markgoals7519 2 months ago Well Done. I learned a lot. Great job. Reply @afonsogarcia9997 @afonsogarcia9997 9 months ago Would have been interesting to hear the subject of stem cells addressed. Could stem cells cancel out the downside to HgH ? Reply @sunnyinvladivostok @sunnyinvladivostok 6 months ago 34:38 "I need to eat once a day unfortunately" It's interesting hearing the early part of discussion and the emphatic value of maximizing the time not eating (e.g. not eating for 2 - 3 days at a time), and framing it within the psychopathology of various eating disorders like anorexia (which also wreak havoc on the body, in a likewise clinical and scientific way). I understand the math works out for the total nutrition received, but the high level concept or ideal of the healthy way to live seems to be something of a contrast. Reply @sandrajezowski1194 @sandrajezowski1194 10 months ago QUE INTERESANTE INFORMACION QUE NOS BRINDO EL DR.DAVID SINCLAIR. A TRAVES DEL PODCAST PODER ACCEDER AL CONOCIMIENTO DE NUESTRA VERDADERA EDAD BIOLOGICAYPODER REVERTIRLA CON LOS DIFERENTES RECURSOS ,QUE NOS BRINDO. ME EMOCIONO Y MEFUE DE MUCHA AYUDA POR FAVOR QUISIERA SABER MAS Reply @blue_samurai_zero @blue_samurai_zero 1 year ago #52? Congratulations on your first year of podcasts! Discovered you 3 months ago. Just starting to get into the swing of running through your channel. Good stuff! Discovered Sinclair some time ago and still haven't worked out a good place to order some of what he recommends... and then it got banned wrongly when being misrepresented to the FDA. Will check out this interview soon! 10 Reply @JosephAccetturoII @JosephAccetturoII 9 months ago I've done this and worked out and I never had stamina. One day I ate a bowl of oatmeal an hour before I went to the gym and I stayed at the gym for 3 and 1/2 hours and had unlimited energy. I felt like I could just keep working out all day. Reply @whitedragondojo @whitedragondojo 4 months ago Brilliant discussion, lots of gold nuggets. 1 Reply @LisaAllenFitness @LisaAllenFitness 7 months ago Oh my gawd. I spit my water across the room when you said you do experiments on your sister. Laugh out loud hilarious. 😂Thank you! 1 Reply @davidramirez7362 @davidramirez7362 2 months ago While education and experience of these gentlemen speak for themselves, I felt entirely overwhelmed by the information. Trying to find a doctor who would remotely be on the same page would be utmost challenging in order to talk through the numerous supplements they spoke about, the varied timing, which to dissolve, etc., all balanced against expensive blood tests that most insurances won't cover. Truly wish there was a simpler path forward for those of who want to do better. Reply @Jblksrollin @Jblksrollin 1 year ago (edited) As a shorter person (5'7), atleast compared to the average in my area. It is certainly comforting to hear that height can affect aging negatively even if it is minor. I will be sure to let my tall siblings and friends know of this great advantage over them next time they bully me for being shorter than them. 24 Reply @leafy6182 @leafy6182 2 months ago Sir in India Fasting is practised from 1000 of years in Hinduism can you make an podcast.Ancient eastern traditions dating back thousands of years lay much importance on fasting as an adjunct to a full-fledged life. Prominent Hindu scholars believe that the purification of the body at the cellular level happens when the stomach is empty and the systemic functions are allowed to re-synchronize themselves. Most commonly, fasting in Hinduism takes the form of a spiritual sadhana, festival observance or penance. 1 Reply @rpratt7718 @rpratt7718 5 months ago Wonderful discussion!!! Reply @AbdulDean448 @AbdulDean448 7 months ago It makes sense, so many body builders have died young from taking growth hormones 2 Reply @brushbros @brushbros 9 months ago Long story made short: "Some people eat to live. Others eat to live." Greatest video ever. Reply @earx23 @earx23 3 months ago I've heard before about low caloric intake. The common tip from people who reach very high age. The rest of the research is simply brilliant, though. This will change the way we live in the 21st century. Reply @roadrunna. @roadrunna. 1 year ago This is still better than any movie released since this episode. Such a high repeat value I can watch it for fun sadly not with popcorns, two of my most fav scientists today 160 Reply 4 replies @googleuser-one @googleuser-one 9 months ago (edited) Lol you guys are more knowledgeable than the drs you see … or they simply dont care. Bottom line is to learn from your videos how to self evaluate. Thanks!!! Reply @kamsinmirchandani @kamsinmirchandani 8 months ago This was incredible. According to Dr David Sinclair - what is the right level / number for Ferritin? Reply @user-cz6gm4dd2h @user-cz6gm4dd2h 6 months ago amazing info, thank you both Reply @CptDangernoodle @CptDangernoodle 9 months ago An interesting observation about his Metformin regiment: Here he says he takes Metformin along with Resviratrol in the morning. However, a month later on his own podcast he says he now takes Resviratrol and NMN in the morning, and Metformin after dinner. 1 Reply @x83ix @x83ix 2 months ago I am a US MD graduate from a top 20 medical school, soon to be board certified in Internal Medicine. I practice Primary Care in California, and much of my time is spent counseling patients about blood test results. Many patients ask for blood tests that they have no idea how to interpret. For the general public without any science or medicine background, I don’t like to order a panel of blood tests that won’t lead to meaningful changes in their lifestyle or health status. Sure, it can increase a level of health-consciousness if there is an abnormal result, but it just as frequently leads to illness anxiety and increased healthcare utilization that doesn’t make a long-term impact. 1 Reply @maesingsmaeplays3407 @maesingsmaeplays3407 1 year ago Trick to getting your blood work done is tell them you've been eating vegan! I've been vegan 8 years (perfect bloods) and they panic every time and say we should check everything ASAP, hahaha. Also, thanks Andrew and David, been hoping for this one and it did not disappoint! Well wishes to you both for 2022. 47 Reply 5 replies @jamesgarvey8402 @jamesgarvey8402 4 days ago I want that podcast to go longer! Reply @mrb5606 @mrb5606 4 months ago I completely believe in calorie restriction and longer life. And it only in a very limited amount of experience but I've got two clear examples. My gran is 94. About ten years ago I told her she was too underweight when she told me she was just below 8 stone. I went through the amount of calories she ate with her in a day and it was coming out at 1100 calories! She eats an old school meat and two veg diet although regularly eats dinners such as boiled potatoes, boiled eggs and boiled cabbage! She's still going strong today and I wouldn't be surprised if she easily makes 100. The next one is my dog. I've got a 15 year old spaniel. It wasn't until recently I was told by the vet that I'm probably under feeding her and have done for years. She's always been really lean and full of spaniel energy so I'd thought she was OK with what if fed her. However, when I looked at the recommended amount of food a day she should be eating I've always under fed her. Yet she's 15, which is very old for a spaniel and still going strong. Reply @dayyego @dayyego 10 months ago 80% of our longevity is up to our life choices. 20% is up to our genes genetics. This is good news 1 Reply @RenaWith @RenaWith 9 months ago This was really helpful 👍 Reply @viktorija97 @viktorija97 1 month ago So shame I found this podcast too late.. but better later than never 1 Reply @juicebox86 @juicebox86 1 year ago Huberman Team; You're truly making a positive impact in my life. The information and the way in which it is presented leaves me feeling empowered. Finally caught up to your most recent podcasts after binging all last year to catch up. I look forward to being hooked to the Lifespan Podcast as well! 5 Reply @brefishburn7478 @brefishburn7478 6 months ago (edited) This is very interesting. If eating less is helpful, I wonder then, why people with restrictive eating disorders lose their vitality. This obviously valid scientific information seemingly goes against all the eating disorder recovery protocols (basically never skip meals and eat consistent macros several times a day) and makes me wonder if all that advice I got in my own recovery process actually did me more harm physically, while it may have still been psychologically helpful.... 🤔 Also, I wonder how this advice might be different for menstruating women. 1 Reply @user-gz2hl7qt6o @user-gz2hl7qt6o 8 months ago I recently listened to your conversation. I wanted to share some information that may be of interest to you. Research papers indicate that niacin does increase NAD+ in both muscle and blood, but the effect may be dose-dependent. In a study conducted by Pirinen et al, blood NAD+ increased up to 8-fold, and muscle NAD+ of patients reached the level of their controls when they administered an increasing dose of NAD+-booster niacin (750-1,000 mg/day) to patients and their matched controls for 10 or 4 months, respectively (Cell Metab. 2020 Jun 2;31(6):1078-1090.e5). Similarly, in another study by the same group, a dosage of 100 mg of niacin did not significantly increase NAD+ levels, while a dosage of 500 mg increased NAD+ by 5.6-fold. These findings suggest that NAD+ production may indeed be dose-dependent. Although I am not an expert in this field, given that niacin is one of the precursors of NAD+ and the historical success of Vitamin B3 in treating Pellagra and mitochondrial myopathy in patients over the past 40 plus years, it seems reasonable to expect that Vitamin B3 supplementation could increase NAD+ production in the muscle and blood. I greatly respect and appreciate your public health education podcasts and would love to hear your thoughts on these findings. Eun-Hee (Park) Cirlin, Ph.D. 2 Reply @veramentegina @veramentegina 9 months ago amazing conversation. thank you! and Dr Sinclair looks so young.. hard to believe he is in his fifties. I am glad he doesn't do cold water stuff. I was feeling guilty.. Reply @MistyAndBonnie @MistyAndBonnie 2 months ago One of the best podcasts ive seen. 1 Reply @310sbell @310sbell 10 months ago I was forced to quit drinking in 2021 (DWI) the result was that I started focusing on being a better version of myself. Actually applying the data I've harvested off YouTube. I'm no doctor but I've been able to coach friends and family members to weight loss and improve their T2D and HBP. I wish I'd known about/had access to an age test when coming into this life change. I just turned 47 and I still think I'm 25. Feels awesome to be healthy. Living a better life than I ever have thanks to videos like these. 🛩️☁️🪂🤙 Reply @supremecanine6848 @supremecanine6848 8 months ago Dr. Huberman, thanks for making the world a better and healthier place. Reply @thor373 @thor373 7 months ago About stevia: noticed on myself and little later on wife that after prolonged (2 years) daily usage started getting hunger bangs with very specific desires (foodwise, down to ingredients) and depression. After 1 day without it everything went to normal. Reply @jmc0369 @jmc0369 7 months ago Great discussion. Almost shocks me too, that a "longevity" scientist would drink soda. But then I looked and he also got mRNA'd and called that science. Reply @DonRua @DonRua 9 months ago Thank you for an informative lecture. My wife and I take 250gm each of NMN and resveratrol a day with a small cup of yogurt. We both suffer from excessive flatulence. I usually get this when I eat a lot of heavy/greasy food that my stomach can not digest. My wife is extremely lactose intolerant as well (yogurt?) All inputs are welcomed. Thank you in advance. Reply 1 reply @FreeAllenWrench @FreeAllenWrench 9 months ago I remove 6 layers of my skin with scotchbrite pads and expose my internal organs to oxygen every day. Thank you Dr. Eclair. Your advice has change my life. 1 Reply @demimack5837 @demimack5837 4 months ago Hi I have a question. What is the best regimen to get the longevity benefits of fasting but also eat enough protein and calories for muscle gain? Also how does a 24 hour fast affect my muscle gain? Is it best to do the 16:8 and just eat 1g per body lbs of protein in that window? Reply @potbellygoblin2495 @potbellygoblin2495 10 months ago thanks for putting education stuff out there for everyone. I never adapted well to the standard educational system and didn't do well at college, but I still love learning. Thanks to this kind of content I can still feel like I am learning and broadening my horizons. 42 Reply @BloomByCC @BloomByCC 3 months ago Menopause is brutal. It led me to David Sinclair and life changes... i feel so much better but still not the same as before. We desperately need more research to address this bro real issue affecting over half the population. Reply @oceansoflorewi @oceansoflorewi 4 months ago I'm turning 38 this year and I look a solid 25-28. As good as it sounds and appears- It's actually quite aggravating to be youthful as people respect you less than you would if you looked 40. It sounds like a petty complaint but once you hit the wise age of 40 you are tired of most things and beyond over being bossed around and demeaned as you figured out how to do things your own way. I'm treated like a boy and not a man. I never thought i'd care but now I know what people mean when they are in this situation. In my 20s I hated responsibility I just wanted to have a light hearted day and have fun- turning 40 I want to be respected and be useful. Aye Reply @soje113 @soje113 8 months ago This interview is beautiful. 1 Reply @markjohnson8642 @markjohnson8642 2 days ago I read Ori's warrior diet book when it first came out. It had an influence on my habits. Reply @tormentoxx @tormentoxx 10 months ago I'd love to see this guy in 10 years. Reply @ijaz8888 @ijaz8888 1 year ago Two of my most admired science professionals in the same room together - Happy New Year to both and keep up the great work !! You both are Awesome 👍👍 19 Reply @Overland_Scenic_Remote @Overland_Scenic_Remote 7 months ago Super podcast, love it😎 1 Reply @melissaperez5982 @melissaperez5982 6 months ago You very quickly made reference to different heritages genetically being predisposed to better metabolize different foods. My brother and I were just discussing this. Did you do a video that discusses this more fully I can look at. Reply @thomasgibbs1825 @thomasgibbs1825 10 months ago Long Live Dr. David Sinclair! 1 Reply @eyeswideopen8735 @eyeswideopen8735 9 months ago Aussie Aussie Aussie !!! I think im a closet nerd...I love this and all your interviews Andrew. I think I'm addicted. Love ya work Sir. Reply @carlosjuvencio-ew9xn @carlosjuvencio-ew9xn 3 months ago Would love a video on LGS - a Seizure Disorder I have. Thank you. I am non-epileptic. Reply @julielynn972 @julielynn972 1 year ago I would love it if you were to do a video on Alzheimer's Disease and other dementia processes some day. My mother has it and her father did also. (Hers could be a mixed dementia and we're not 100 percent sure it's AD but we think it is because the majority of dementias are. Supposedly.) It is heartbreaking. Anyway, thank you so much for this channel. 154 Reply 38 replies @computerhelpcc @computerhelpcc 3 months ago TallyHealth is Sinclair’s co to provide cheek swab test of biological age 4x/yr. Alas, my first 2 tests rated me 5.5 yrs OLDER than my age and I am fit, unstressed and eating well. So, added serious cardio 2x/week, and now thinking switch away from red meat to chicken. Regular bloodwork has looked very good for decades too so just goes to show newer tech can be illuminating…. Reply @nancyreilly1873 @nancyreilly1873 2 months ago Please accept an infinite Thank you Dr. David Sinclair and the one and only Huberman. Reply @amyjohnson6866 @amyjohnson6866 3 months ago My doctor has recommended Red Yeast Rice Supplements to lower my LDL. Wondering what your perspective is on this with regard to any potential connection to memory loss/Alzheimer’s. My mother is in a memory care facility, therefore I’d like to avoid traditional statins. 1 Reply @varusquinctilius3309 @varusquinctilius3309 9 months ago David‘s 52? 😮 early 40s was my guess… I‘m following his protocol right away😄👍🏼 Reply @tabimansour @tabimansour 3 months ago Wow, I never knew that my favorite scientists are both in one video. Reply @barbarayorkwoodside3716 @barbarayorkwoodside3716 1 year ago Looking forward to Dr. Sinclair’s podcasts! Thank you for adding him to your roster of great guests. Happy New Year to you and your including your great staff and support teams. 7 Reply @sacredpaw @sacredpaw 2 months ago I used to listen to Ori Hofmeklers podcast, also have his books. Loved all his information and protocols. Reply @iVidyut @iVidyut 1 month ago It is very strange to hear two doctors discuss how to get tests done. I'm like seriously? You got bodybuilders doing them. In India you can just book one on whim... and then I realise it is a plug for inside tracker. Facepalm. Well played. Reply @jiujitsubeast15 @jiujitsubeast15 9 months ago I would love to know how to approach a child’s diet with this in mind! Reply @annamartino5681 @annamartino5681 5 months ago (edited) Dear Dr Andrew Huberman! Thank you very much for your Videos and amazing guests. Could you please explain would eating more Carbs in the late afternoon or evening be stored as Fat when most likely people don't exercise after dinner? Also, wouldn't it be true that Milk and Diary products which undeniably have milk proteins which our body easily converting into Blood Glucose (aka Sugar) is not much different than eating other Carbs especially if together with other Carbs - essentially fueling our steady supply of Blood Glucose and might be helpful for challenging Brain Tasks such as for Students and Professors and Professionals and maybe even Gym Exercises? Also, if one wants to Lose Weight and their BMI hits the personal spot of just 2-4 kg above ideal and they noticed they are at their age becoming almost Pre-Diabetic based on Fasting Bloodwork Tests even after 2 days fasting for example for a small outpatient surgery such as UFE or something else like Gastroenterology upper and lower endoscopy, then what would be the ideal food choices for breakfast, lunch and dinner based on Hormonal Energy Metabolism and especially if due to their life in the office at work for 12-16 hours they typically don't have a chance to even get a 15 min lunch break away from work... (as that's how most of professionals lives are especially if they have any Career path and want future in their Professional field). Thank you very much for your recommendations. Reply @fannyvalentino.1951 @fannyvalentino.1951 8 months ago Great podcast ! Reply @ssiddarth @ssiddarth 1 year ago (edited) This conversation is like one of the best Christmas gifts ever, thanks Dr Huberman for having Dr Sinclair on the podcast and asking such great questions 4 Reply @s-eyesel @s-eyesel 3 months ago Another awesome interview! Fasting fasting 🎉🎉🎉 Reply @gb4939 @gb4939 9 months ago Super interesting ! Thank you very much for sharing. Reply @transformwithloveandrespec3881 @transformwithloveandrespec3881 8 months ago I use the reverse aging technique highlighted in Sergio Magana Chapter 10 "Caves Of Power". 18 minute routine used daily. Reply 1 reply @ana3256 @ana3256 10 months ago I would like Dr Sinclair talks more in this podcast with out interruptions. Reply @s.a.l.450 @s.a.l.450 8 months ago How does one keep inflammation down in the hypothalmus? What supplements would you recommend as applicable for anti-inflammatory effects and for cartilage regeneration, or preservation for those with arthritis? Reply @motherofcrows5911 @motherofcrows5911 1 year ago Every time I hear Sinclair talk I learn something new. Your interview here was just perfect and covered a wide range of actionable longevity strategies. 22 Reply @drunkensessions @drunkensessions 4 weeks ago I miss this guy, RIP David 😢 1 Reply @ccagle449 @ccagle449 8 months ago (edited) Who else has never heard of these supplements before? The other population has access to different kind of information. Thanks for sharing . Reply @drironmom6815 @drironmom6815 2 weeks ago About ordering labs - as a functional medicine doc, I’d love to get all kinds of labs - and I used to just order them until my patients showed me bills they got from the lab for over $15,000. Insurance won’t cover much beyond the basics Reply @brittanyirvine1448 @brittanyirvine1448 9 months ago This is some of the best content on the internet. Thanks very much. Brittany - U of Ottawa Epidemiology. Reply @walterleipzig @walterleipzig 1 month ago Dr Huberman was looking for a method to identify a method to identify tumours in the body. I was recently given a PET scan, after ingesting a radioactive sugar solution that was supposed to be attracted to cancerous cells. (I was given a clean bill of health.) Reply @sharonp.6505 @sharonp.6505 1 year ago What an amazing podcast! I've watched dozens of interviews with David Sinclair. Dr. Huberman asked different and intriguing questions that no one else has asked before. Two brilliant and forward thinking scientists together, sharing provocative ideas and insights. This podcast gets my vote for "best of 2021". Thank you!!!!i 7 Reply @NinZine @NinZine 9 months ago A bit surprised he has not heard of Warrior Diet or Ori as a researcher about longevity and intermittent fasting. I mean, it would have come up. Smells funny. On the other hand, he takes a lot of knowledge and put it in a decent package, which is his protocol and own literature. Reply @DharmaDharma11 @DharmaDharma11 1 month ago Thanks Doc. I notice your short video get a magnitude higher view rate than your long videos. Would it be an idea to take your 1 or 2 hr videos and also produce a short summary (under 10min?) thanks Reply @0121bassline @0121bassline 8 months ago I do the 18/6 fast starting from 6pm so I'm asleep during most of my fast which makes it way easier. I do this twice a week for a month as I do bodybuilding and struggle to keep my size. Would that be enough to gain all benefits though? I also read that its more beneficial to do alternative day fasting so you fast one day then not the next then fast again etc . Unsure why it could be better than just fasting for 2 continuous days though ? Reply @rocoHuana @rocoHuana 10 months ago Thank you so much but what I am missing is a short summary of most important things people should do to kind of reverse ageing or at least slow it down Reply @ValeriaVincentSancisi @ValeriaVincentSancisi 4 months ago Please have him back for an update on the regenerative research... Reply @allangraham3649 @allangraham3649 1 year ago Thank you to yourself and David for your time and to everyone involved in making these happen as ever ! 6 Reply @magicalmothers @magicalmothers 8 months ago I thought this man was in his 30s. He said he is 52. Obviously, he knows what's up! I am 37, but look like I'm in my 20s. I feel like I'm reverse aging. I fast every day simply because food makes me sleepy and I have a lot to get done. So I'm 104lbs, 5'2 and look super young. Full set of abs. Extreme muscle tone and I do not work out. Someone should study me! Reply 1 reply @Grox44 @Grox44 10 months ago 32:04 what helped me greatly with less plaque build up in the mouth is taking a strong Probiotic with a strong Prebiotic. Any legit HMO (human milk oligosaccharides) is good. Was taking Holigos before was the best one for me. Reply @1giveme @1giveme 10 months ago Love these guys work Reply @maxyousofirahimi4555 @maxyousofirahimi4555 5 months ago Amazing people and amazing information! Reply @phytopanacea1141 @phytopanacea1141 10 months ago The causes of aging are: cellular toxicity, malnutrition, psychological trauma 1 Reply @bernardradcliffe6240 @bernardradcliffe6240 1 year ago One of the all time greatest podcasts in relation to health and longevity. Thank you guys. 7 Reply @gstudio33 @gstudio33 3 months ago When I was flying, I just stood before the scanner. Someone came over to me and said, Are you opting out?, I said yes. They then took me around the scanner and basically patted me down. I had a pacemaker and wasn't about to be wanded...no problem. I think they encounter all kinds of medical issues and concerns. Reply @RenaWith @RenaWith 9 months ago (edited) I am 46, people think I'm 30 and some thought I'm in my 20s and were shocked that I have 18 year old boys. However, I have many illnesses pre diabetic, sinus issues, female issues, thyroid issues, gut issues, vain issues, I can't even name them all..my skin looks great and it's soft, I have no wrinkles, no grays. I'm just saying...for me I can't agree with being healthy looking young. Unfortunately I'm just surviving which is why I'm here...to learn even more. 1 Reply @kefilia @kefilia 1 month ago Thank you for this!!!! Reply @yuwishiii2155 @yuwishiii2155 10 months ago Sir can you do a podcast on neurobiological aspect of genes and how it makes someone smart physically attractive and so on and how does father and mother gene contribute to overall wellbeing of the child !? Reply @cosmospray @cosmospray 10 months ago This man is fascinating Reply @ES-ex5it @ES-ex5it 1 year ago I have watched many hours of David Sinclair interviews and I was able to gain new insight thanks to your interviewing skills. You posed certain questions with a clinical edge that other interviewers lacked, and you also relayed questions that "lay people"/non-scientists asked you. It was very well rounded and accesible. The timing of the podcast is great too. As we approach the new year it is refreshing to have scientifically proven ways to improve one's life paired with actionable steps. Thank you for this interview. 8 Reply @michaeleppel1126 @michaeleppel1126 10 months ago The second he drops his age the entire video becomes so relevant. 2 Reply @Kavaitsu @Kavaitsu 3 months ago "NMN is a precursor to NAD, a life necessity molecule, and makes the NAD molecule in one step. Two weeks of proper dose of NMN will double your NAD levels in the blood" Reply @cezarpereira761 @cezarpereira761 1 month ago Besides the useful information I like Sinclair's attitude Reply @clairebeane3455 @clairebeane3455 8 months ago (edited) Welp, that settles it, I didn’t hit puberty until I was in my teens, I didn’t even get my wisdom teeth until I was in my thirties, and was carded for drinks into my fifties. I am also 4’9” tall and weigh about 95 lbs. I should live a long and healthy life … Then again, I have dealt with a great deal of stress in my life and have not always been kind to my body. So I suppose it really is all a bit of a crap shoot. Reply @jamison1280 @jamison1280 3 months ago Body size and duration of life equation (in my hypothesis) has to do with how far the blood has to travel to reach the vital organs and (not mutually exclusive) the strength of the veins. There is also a relationship (in my hypothesis) between the size of the organs in relationship to the size of the body. Reply @agnieszkalorens4246 @agnieszkalorens4246 1 year ago I love how you encourage other scientists to start their podcasts! But also episodes with guests, no matter how interesting they are, just make me appreciate episodes fully conducted by you. I love the logic in the sentences.. it’s so pleasurable to follow🤤 42 Reply 3 replies @dr.gangaa1641 @dr.gangaa1641 10 months ago Regarding cholesterol: I’m a dr from India, here we eat mostly carbs and we all are with higher levels of cholesterol. I personally think after seeing many pts reports and mine too… ppl having high LDL are low in Vit D3, Vit B12, low Sex hormones and they have gastritis (low bile). LDL is the precursor of all hormones. In vegetarian I see high nonHDL, low HDL and high Tgl/ LDL/ total/ CRP/HsCRP, with low Vit D3, b12, sex hormones. Few races are very sensitive to statins in terms of rhabdomyolysis. Loss of muscle with in months times of statin initiation and HbA1C seems to be increasing. As per my practice I don’t use statins as prophylactic. Higher level of LDL doesn’t cause any heart disease. High Tgl has to be treated with ezetimibe or finofibrate depends upon sex. Should never try to reduce the level of LDL, it’s the mother hormone for all conversions likes 17 to 25 hydroxy cholecalciferol, to produce bile, intrinsic factor cells in stomach & sex hormones. Correct me if I’m wrong. 1 Reply @genesisauctions @genesisauctions 7 months ago You could also try using Gynostemma pentaphyllum (Jiaogulan) considered as the herb of immortality, as a replacement for Berberine, Reply @marilyngilman5666 @marilyngilman5666 10 months ago I have take Berberine for years. I believe it mimics the effects of Metformin. Reply @rosiek649 @rosiek649 3 months ago (edited) really colloidal silver is the only fluid that has helped calm and moistens my eyes. I've used it for over a decade! I have thrown away all the other brands. No other eye drop works even went to the Optometrist recently and what they suggested on amazon was good but it doesn't beat colloidal silver! Can't believe Andrew Huberman is saying this. It also instantly heals cut wounds whereas no other works! Yes I've seen people with thick mucous in their lungs, also they are non-smokers. They take it and it's helped them if it wasn't for that they'd have to run 5 miles a day to clear out the mucous. So what do you have to say about that? That's not it there's tons more people that have got so many benefits from colloidal silver. 1 Reply @auroranight9934 @auroranight9934 8 months ago so happy you mention Estrogen every time talking about Testosterone Reply @raquelvidales7568 @raquelvidales7568 11 months ago Thank you Andrew for this awesome podcast! I’ve read Dr Sinclair’s book, and I’m so grateful that you have covered a lot of open questions that are not so easy to Digest, specially for the non-scientific people (like me). It really helped me and clarified a lot of the Q’s I had myself, and that you have covered them in a very easy going chat with him, by sharing, discussing and doing a deep dive on how the ageing can be reversed and so forth… it was such a great idea on inviting him to your show! I’m looking forward for your next updates and shows! 9 Reply @richa2982 @richa2982 10 months ago It has a rather separate system for women , tuning inn their menstrual cycles. Cover that too 💙 1 Reply @SubtleYoga @SubtleYoga 10 months ago (edited) So, as much as I love your podcast and the work that you do, there is an elephant in the room - disordered eating issues. When Dr. Sinclair talks about how optimal his 2 hour windows of eating is , this gives license to folks with disordered eating and addictive tendencies to continue their behavior - which is quite harmful. Eating is not just biological process - it is psychological, social, spiritual, and global as well. The psychological stress of severely limiting times and foods is radically unhealthy for many people - it contributes to the upregulation of the SNS, perhaps even more detrimental to digestion and metabolism. Maybe it's okay to live 10 years less? Maybe it's okay to have happy, festive, familial, social approaches to eating where people eat to feel the love of the food being served, to live, and to be together. Maybe it's okay not to have a perfect photoshopped bod. Maybe it's okay to be human. Reply @WildernessgalM @WildernessgalM 9 months ago Y'all should read, "Nutrition & Physical Degeneration", by Dr. Weston A. Price. Also, I personally "don't believe drugs are part of the answer".... Thank you for sharing. Enjoyed your video/discussions 😉 Reply @Mohammadali_9999 @Mohammadali_9999 8 months ago I love you Mr.Huberman, I've said it before and say it again, you are my hero. Wish you the best,from Iran. Reply @ginacardarella @ginacardarella 9 months ago That was the very first book I read about fasting he also talks about Roman or yours I believe and how they only ate one meal a day great book Reply @JenniferMyers @JenniferMyers 1 year ago This was excellent. I’m sharing this with all my loved ones; required viewing for my family. Thank you for the education. I feel ahead of the game because my family and I have been practicing time-restricted feeding for a number of years now. 80 percent of aging and disease comes down to epigenetic factors. I’m always emphasizing that, but many people seem to grossly undervalue the impact of lifestyle habits, thinking everything is the sole and direct consequence of our genes; simply untrue. Also, “if you don’t enjoy life, what’s the point?” 👏👏🙏 52 Reply 5 replies @keewatinrealestategroup @keewatinrealestategroup 10 months ago ahhh - if you follow people long enough the truth always comes out. While an interesting topic and factual there is always a reason why these programs/projects are funded and explored. After seeing several of Dr. Sinclair's sessions on the web (Rogan et al) the real reason for advancing this is finally mentioned. While Dr. Sinclair is in the know or is just being used is not of question here. He does mention it at the end. A "kind of Credit Score". We can monitor everyone and know everything about your health and give you a score. And what pray tell are the masters of the universe going to do with this data and your "health score".....ask the Chinese. Mad science....can you say Pfizer/Moderna....just saying 1 Reply @belindaratcliffe6673 @belindaratcliffe6673 5 months ago I love your show! Reply @ihateandreykrasnokutsky @ihateandreykrasnokutsky 9 months ago (edited) It takes some courage to talk about death from aging. Most people prefer not to think about it and even insist that we shouldn't fight death, which is a pretty cruel thought. We fight a flue or cardiovascular diseases, why shouldn't we fight death from aging and seek immortality? Reply @elizabethsilk2195 @elizabethsilk2195 4 months ago Thank you guys ❤🙏 Reply @Tony-un3vf @Tony-un3vf 3 months ago I’m curious, I have thought of disease as basically being excess oxidative stress , when the body cannot keep up with the pace in which the oxidative stress is being produced, thus becoming a disease. However, you said that antioxidants didn’t turn out to be what you expected in regards to the anti aging process (my words, not yours). Yet, if a person develops a disease, the first thing I would think of doing is using antioxidants, primarily vitamin C as the first line of defense and using other more powerful antioxidants to recharge the vitamin C when it uses up its two electrons. These other antioxidants would be glutathione and alpha lipoic acid. In fact, anyone who is sick, is deficient in glutathione levels. My question to you is; isn’t aging as we now know it, an excess oxidative stress condition? Reply @Consistent30 @Consistent30 1 year ago Would love a whole episode on Electrolytes and it’s importance to the human body. I feel like electrolytes are really overlooked by many doctors 19 Reply @jamesb2166 @jamesb2166 5 months ago I was shocked when this doctor said he gave up sugar when he was 40. I thought he was about 25! Reply @SunilKumar-es1gb @SunilKumar-es1gb 9 months ago I love your work Reply @airmedh @airmedh 9 months ago I wonder, are regular saunas pro aging? In the 70s there was a lot of research done in Finland because people were dying early. I think they concluded that it was due to diet, as they drank a lot of milk. I wonder if the sauna, causing high HGH levels, was at least partly to blame. Reply @MP-kj8to @MP-kj8to 4 months ago I'm currently 29, in nearly optimal health and training 6 times a week, taking zinc, omega3, magnesium malate, eaa's, vitamin D, a few B, creatine and taurine. I feel fantastic but i don't know if someone of my age and physical state could get benefit out of taking NMN and Resveratrol. Should i wait till i'm 35/40? I have the same doubt about ca-akg and glynac (glycine + n-acetyl Cystine) 1 Reply @jessedavis13 @jessedavis13 10 months ago I’m really surprised he called Diet Soda a 1 on the scale of bad for you foods 😮… I would have guessed diet sodas were worse than regular. I don’t drink any, but for the general population, I hope he’s right! Reply @denisemc607 @denisemc607 1 year ago Thanks so much to you both for outstanding content in a friendly and accessible format. I am so grateful for this content. Like David said the world needs good cutting edge science to inform their doctors. I showed mine Inside Tracker in the UK 🥰 5 Reply @DariaRatliff @DariaRatliff 3 months ago By the way, guys... we are gonna all die 🤭Just being funny, well, ok. Love this podcast. Love Huberman! Reply @gratitudehealingarts @gratitudehealingarts 10 months ago I have worked with clients to reduce their CRP levels by only manual therapy of the Vagus nerve and visceral manipulation, as well as increasing ACH levels through gotu kola and huperzine A. My client had dramatic reduction in CRP and his PCP did not believe it was from my work with him, but there was nothing else he was doing. Reply @leanndove7546 @leanndove7546 10 months ago I agree with everything he said except taking Metformin. I don’t understand why he would take it. That drug has so many terrible side effects. 2 Reply @surahalani @surahalani 1 month ago In Islam we have a 30 day fasting a year in Ramdhan from sunrise to sunset , also (optional ) but encouraged religiously fasting Mondays and Thursdays of every week with the same hours . Reply @chrisevans8920 @chrisevans8920 9 months ago With regard to the X-ray topic. How does that relate to DEXA scans, MRI's, and other medical scans? Is there any info out there about which are most harmful so that I could assess the risk against the need for information? Reply @poshpasha @poshpasha 1 year ago The internet creates a spawn of information, but information isn't intelligence. Thank you for continually putting out a sense of logical thought and allowing the public to sit in on conversational engagements between intellectuals like this. Excellent work. 4 Reply @martythibodeaux5461 @martythibodeaux5461 3 months ago What is your take on TMG along with NMN? If recommended together what is the protocol? Take together or one in the morning then the other in the evening? 1 Reply @hi_saylee @hi_saylee 10 months ago I knew I wasn’t crazy. Lol. I do this too 33:22 I train fasted and feel stronger. If I break my fast, it’s only because I would drink a Gatorade or Powerade zero to make sure I have some electrolytes. Reply @huenjeffrey5924 @huenjeffrey5924 4 months ago Are we not going to talk abt the fact that Dr david Sinclair looks like he is in his 30s while he is already 52?! thats real reverse aging right there! 1 Reply @shishi-uq1nu @shishi-uq1nu 9 months ago There are many different types of NMN, they differ by numbers. As an ordinary customer, I have absolutely no idea of which one is suitable. Please dive a bit deeper in this issue in the future podcast, 🙏 please 1 Reply @jordanmeija7384 @jordanmeija7384 4 months ago Dr Mindy Pelz, brilliant expert on fasting. 1 Reply @eliotsalandybrown @eliotsalandybrown 1 year ago Thanks to you both for bringing us this valuable wisdom 🙏 13 Andrew Huberman Reply @2011ekon @2011ekon 6 months ago Regarding Dental cavity X rays around 1.58 min : interesting that he had to dispute it in the US because in Poland you don't get an X ray that easily (you have to ask or you only get one of the dentist can't see or diagnose clearly what is wrong) and you pay extra. Not usually paid by insurance or workplace covered incentive. So he did the right thing by questioning why he needs those by default if his teeth are fine! I always question things that don't make Sense and seem to result from some old fashioned procedures. Please do the same , we have choice and a say! We are the client . The client is always right 👍 Reply @jakejessen8927 @jakejessen8927 7 months ago Is developing gallstones a concern when doing fasting? That is my biggest worry. Reply @davidminkin8861 @davidminkin8861 10 months ago Really intriguing interview! Reply @firepowerjohan @firepowerjohan 9 days ago (edited) My big question that I am seeking answer to is. Does increased strength without gaining weight increase longevity since you will lose strength eventually as you get older? I find if doing only fasting and some cardio activity that my muscles lose some strength. I also find if I do both cardio and resistance training, my body will not be able to do as much fasting as without. Sometimes I need to fill up energy, even eating sweets. Now, if this can be done and maintain a constant lean weight at abou ät 22 BMI improve longevity better than being more extreme with fasting? Im talking doing 16/8 around 5 days a week and then be a bit more loose 2 days due to all the recovery from exercising. I do Very strenuous exercises sometimes, like a recent record was 181 average heart rate during 40 minutes on cardio machine (Stair master), but I also rest every other day. Reply @HomoLuminous33 @HomoLuminous33 3 months ago So funny watching about anti aging I am evolving into the new Human Homo Luminous We don't do age and heal different I am a sun gazer that activated my DNA ❤ Reply @sunnypreps7394 @sunnypreps7394 1 year ago "We'll all be like Dead Pool." The same day I listened to this, my mom commented on my 92 year old step dad's uncanny ability to heal quickly. She was a nurse and nursing instructor and has noticed this ability over their 40 years together. 37 Reply @tylerjcranford @tylerjcranford 8 months ago The problem with meat and eggs isn't the cholesterol, it's the saturated fat (among other things - heme iron, neu5gc, TMAO, et cetera). Eating saturated fat raises LDL cholesterol, not eating cholesterol. 2 Reply @JM-dv1zq @JM-dv1zq 10 months ago I say this with the utmost respect for David Sinclair , and Andrew Huberman. I find it insulting to state that you can "reverse" the aging process !! Reply @brianw8165 @brianw8165 5 months ago Thoughts on Urolithin-A or, more specifically, Mitopure from Timeline Nutrition? They claim through scientific studies to increase and improve mitochondrial health and thereby reduce aging and improve performance and strength. Thanks! Reply @perunstrength4598 @perunstrength4598 7 months ago (edited) Ok, but in regards to strength athletes, or even just hobbyists/amateurs who partake in intense training regimes - example like myself, someone who's 6ft8 and weights 220-230lbs - how do you maintain optimal level of protein intake (1.6.-1.8g per kg of BW, so in my case somewhere around 175g of protein per day) and calorie surplus around intense training sessions? Knowing that much larger protein bolus doesn't actually help stimulate muscle protein synthesis, so eating let's say 60g of protein per meal wouldn't really be optimal? Considering day job, etc, maintaining even a 16/8 protocol would make it practically impossible, wouldn't it? Really curious about this, as this is a very important part of my lifestyle and health, but I'm very curious about incorporating regular fasting into my daily regime. He also talks here about reduction in growth hormone, but some studies have shown that particularly long periods of fasting actually increase GH quite significantly, not to even mention the importance of GH on muscle growth/maintenance? Reply @venomsorceress @venomsorceress 8 months ago This is great, for decades we were told that breakfast is the most important meal of the day. They lied to us. Reply @billkemp9315 @billkemp9315 1 year ago Great podcast! I always love to hear what David has to say and you Andrew ask all the right questions. 18 Reply @davidvandeusen3424 @davidvandeusen3424 9 months ago Sinclair had the supplement NMN off the market so that he can tinker with it,patent it, and personally profit from it at the the expense of ordinary people who no longer have access to it. What a guy 2 Reply @gratitudehealingarts @gratitudehealingarts 10 months ago If you have a candida overgrowth, would you then want to avoid resveratrol because it extends the lifespan of yeasts? Reply @Motorsportsinjapan @Motorsportsinjapan 8 months ago Start of the day is best for fasting. Breakfast is best a few hours or so after you've woken up. Reply @gaellelebray @gaellelebray 8 months ago (edited) I seem to have big stomach sensitivity to the combo NMN and resveratrol. I started with the initial dosage recommended in smoothie and then coconut yogurt. Tried a spoon of olive oil before i have the small spoon of both mixed together (in powder form). Was fine for 2.5 weeks… then I halved the dosage… I have now stopped for 3 days and stomach almost back to normal. So need to get test/biomarkers before I carry on. Reply @Kylie-wc4gx @Kylie-wc4gx 3 months ago You should have Dr. Mindy Pelz on, she's got a book "fast like a girl" and she knows the nitty gritty details of how fasting activates those longevity pathways, and has actionable steps you can take to improve your health through fasting, cus it's similar, but different for woman than it is for men 1 Reply @sonals2021 @sonals2021 1 year ago I am impressed that AH is sharing content during the holidays as well. Super organised! 👌 42 Reply 5 replies @SybRyss @SybRyss 8 months ago (edited) I’m wondering if Helen Keller’s language acquisition post intense sensory deprivation provides an example of what Huberman is talking about regarding the re-activating of neural plasticity w regard to language development? Language acquisition equivalent to an infant’s capacity is supposed to cease after the sensitive period (thanks to neural pruning) and Keller’s case (seems to) provide a unique exception to this. (Discussed around 1:38) Reply @jorymaloney4025 @jorymaloney4025 4 months ago Dr. Sinclair mentions taking an NMN supplement to synthesize NAD. Is this somehow better than supplementing NAD directly? Reply @reginaerekson9139 @reginaerekson9139 6 months ago 4:12 😂 if I were bad Huberman: this podcast is my volunteer work to help all you sloppy messy people out because you’re just too clueless to figure it out alone. I’m helping you free as a public service in addition to my full time job as a super fancy world class scientist and part time super model (I flex at this point and tear my shirt 😂) - because helping you is helping myself and elevating humanity. (Then I spin on one foot to turn around and walk off like a rock star) 🤣 Reply @kathrynwatkins5510 @kathrynwatkins5510 10 months ago Dr Sinclair can you answer this : where does multiple sclerosis fit into this ?I had perfect health until the age of 40 .Is multiple sclerosis a disease of ageing ? I dont think it can be so I would really appreciate your feedback on this .... Reply @zofiahejaz @zofiahejaz 10 months ago Brilliant .....trully amazing discussion...... 😯 1 Reply @barbarawarren9443 @barbarawarren9443 1 year ago Excellent podcast and an amazing episode! ❤ Loved this! It's 1:30 am and I don't usually stay up this late, however, absolutely couldn't turn it off -- and I'll watch it again when I'm even more awake. 8 Reply @sunnysuze7705 @sunnysuze7705 8 months ago So if high HGH stunts longevity, how do we ensure that sauna (which I’m doing to live longer and reduce all-mortality cause) isn’t just aging us even further? 1 Reply @tonytravels2494 @tonytravels2494 8 months ago David Sinclair cares only about money and his own ego gratification. What a piece of work! Reply @Superfreq69 @Superfreq69 2 months ago With many benefits , when talking anti-aging, has Dr Sinclair ever experimented with C-60 the Carbon Molecule ? Reply @user-wb1gz6ce8d @user-wb1gz6ce8d 5 months ago Hi David this is Daddy writing you, i hope you are doing well. You have a year to come up with a reverse aging therapy that is applicable to human beings. Abrey de Grey will try to do it in a year if you could beat him , we will all appriciated. Reply @jostsomuan8012 @jostsomuan8012 9 months ago David Sinclair looks his age. I hope he aged not bc of his methods but bc of the amount of stress he’s under. I’ll be damned if I spent most my life trying to stay young and end up getting old regardless. Reply 1 reply @caliskanutkan @caliskanutkan 1 year ago I can't even dare to explain how valuable this podcast was. Thank you very much! I would also LOVE to listen to your philosophical conservation. Please consider that. The youth/future needs real influencers like you guys! 16 Reply @richardjosephnovak @richardjosephnovak 8 months ago Sinclair spending years promoting NMN and convincing millions of people to take it and those people reaping great health benefits and longevity is a wonderful thing. But then Sinclair taking part in the banning of NMN appears it could be a problem for his own longevity. I am not really sure if he can hide from this conundrum. 1 Reply 1 reply @ELSAYANG98 @ELSAYANG98 2 months ago Thanks. You are good. This is really very informative! I am a fan of Dr. Sinclair. He is correct. The medical community has concentrated on reacting to diseases when the cure is really slowing down aging. If they had studied aging a decade ago, we may have a lot fewer diseases today, and healthy old people. Reply @honibi628 @honibi628 6 months ago Andrew Huberman is so fascin fas 🥱😴 1 Reply @claraelenadejesus8008 @claraelenadejesus8008 9 months ago Excellent! Question: What's wrong with colloidal silver in the eyes? I've used it successfully mixed with DMSO to reverse the need for glasses. Reply 1 reply @dion789 @dion789 6 months ago (edited) 21:25 Well damn, I was given estroegen treatment as a kid to reduce my eventual height which triggered my period earlier on. I didn't know this was going to be one of the side effects. Reply @nikaa.9408 @nikaa.9408 1 year ago David and Andrew, thank you for your hard work and for sharing its results with the world, and yet for free😊 Can't wait for the pill that will reverse ageing! Good luck with all the research, Dr. Sinclair. 5 Reply @gratitudehealingarts @gratitudehealingarts 10 months ago Acetylcholine levels are a big part of how a person can fast and how their body deals with different nutrients. This guy you are interviewing must have innately high ACH levels and that has been linked to longevity… he likely has genes that are efficient in creating and maintaining ACH levels or potentially a low level of Acetylcholinesterase production. Reply @luciemurphy4436 @luciemurphy4436 9 months ago I'm a little confused because Sinclair was talking about the benefits of taking Resveratrol every 2nd day and then later said he takes 1000mg everyday. Does anyone know if it was everyday or every second day? Reply @sreejithomkaram @sreejithomkaram 8 months ago pure gem Reply @ivanlevtetov6599 @ivanlevtetov6599 2 weeks ago (edited) "I gave up sugar when I turned 40." That guy looks 20 years old! I am amased! Another thing.. kudos to professor Huberman for saying Bulgarian yogurt not Greek yogurt. :-) I am a Bulgarian and I appreciate the accuracy. :-) Reply @juanblanco1267 @juanblanco1267 3 months ago i have the genes that make you look young. i’m 43 but everybody thinks i’m in my 20s. i get it from my mom 1 Reply @drnitz @drnitz 1 year ago Drs. Huberman & Sinclair: I enjoyed this episode immensely. All of the information provided is absolutely fascinating, exciting, and potentially life changing. I was especially intrigued by the discussion at 1:57:32 and beyond, regarding dental radiography. I am an oral maxillofacial pathologist, which is a specialty of dentistry. I graduated dental school and then completed residency training in head and neck pathology. The dental profession does frequently employ radiographic study to identify dental and oral hard tissue pathology, such as dental caries (cavities). Dental school training in radiology heavily emphasizes the physics involved, but does not delve as deeply into the effect of ionizing radiation upon the target living tissue. Student dentists are generally taught that, with the proper lead shielding, periodic radiographs are no more harmful than a few hours in the sun. From what you said, it appears that research indicates that may not be the case. Radiographic studies at the dental office may be more harmful than we think. Unfortunately, dental care providers really have no other way to discover and diagnose oral diseases such as dental caries, bacterial infection of the teeth roots (periapical disease), cysts, tumors, or bone pathology. You mentioned you went 6 years without dental radiographs. Your dentist must have given you a VERY thorough clinical examination, because radiographs provide the majority of the clinical information about what's going on with the teeth and jaws. If your dentist had suspected the possibility of tooth decay or any other dental pathology, he/she would have insisted upon radiographs. We dentists simply don't have any other way to detect and diagnose tooth and jaw problems. I wish we did, and perhaps the future will bring rapid developments in that regard. For the time being, however, please try to understand that your dentist is simply trying to perform due diligence in examining your teeth and oral structures. Keep up the Huberman Lab Project! It benefits the world much more than you may realize. Thank you. 33 Reply 1 reply @mirandaburke3331 @mirandaburke3331 8 months ago I wish they discussed at what age would one benefit from NMN supplementation. Is 20 years old too young? Reply @ritz6982 @ritz6982 6 months ago Retinol is used as a powerful anti-aging active in skincare, because it accelerates skin cell turnover. This leads to increased collagen etc, so it gives a more youthful look. But; I’m wondering if it isn’t actually accelerating the aging of the skin? The more cell turnover, the more copies and “scratches” of the DNA - am I correct to assume this? Retinol makes the skin LOOK younger, but it is wearing the chromosomes faster. Anyone? Reply @pabloramos1750 @pabloramos1750 7 months ago I am surprised Dr. Sinclair did not mention anything about AMLA, neither Plant Sterols when talking about Cholesterol levels. Reply @AnnKrilanovich @AnnKrilanovich 10 months ago I lowered by total Cholesterol 56 points in 41 days with food, fiber, exercise and supplements. How can you say there is no relationship between dietary and blood cholesterol? Reply @claudiaboyden2902 @claudiaboyden2902 3 months ago Great Information!!! 1 Reply @edumontero2953 @edumontero2953 1 year ago I have been following David Sinclair for few months now and he has been interviewed by very smart guys here on youtube, but this was his best interview ever. Great job Andrew, You asked him some amazing questions, this is very educational, I am going to follow you closely from now on. 13 Reply @alexkramer5499 @alexkramer5499 6 months ago Have you considered mental attitude? Positive vs negative mindset and how it affects biology? Reply @ctguitarguy8510 @ctguitarguy8510 10 months ago (edited) Electrolytes only become an issue when you do long-term fasting for say a week or more. I have done up to 3 weeks without eating, and you 100% need electrolytes. It's not really an issue if you fast for 48 hours or less. Berberine has the effect that it does by damaging your liver. Reply @anitamcdonald6626 @anitamcdonald6626 9 months ago Fantastic information 1 Reply @mamacean1 @mamacean1 10 months ago How many times a month/year should you fast 48-72 hours to reap the benefit of autophagy? Reply @lyvsix @lyvsix 2 months ago (edited) I am laughing so fucking hard.... my family and friends have spent my whole life telling me I would die soon bc of my habits... well well turns out that those things are the ones he recommends (eating once a day, exercisiong without taking protein supplements, being a vegetarian, not eating every time I was hungry or not eating breakfast lunch and dinner etc...) also they now come to me looking for advice as to how to look like I do (slim yet strong and younger than I am.... i also like everything to do with skincare so I guess my life habits and all the skincare I do really do work bc most ppl dont believe my age when they meet me...) 1 Reply @luciasanchez5687 @luciasanchez5687 1 year ago Dear Dr. Huberman, thank you so much for staging this wonderfully insightful interview. I was wondering if you could do a podcast on thyroid and it’s role within the body especially with regards to females and of course including all the imbalances that can occur in the thyroid and their downstream effects as well as protocols to heal and care for the thyroid. Thank you so much. 21 Reply 1 reply @adamcraig9834 @adamcraig9834 9 months ago I’m curious - would a low calorie (15) fiber supplement taken in the morning impact the benefits of fasting? Reply @stephanieopenshaw @stephanieopenshaw 10 months ago “If I don’t eat a steak I feel terrible” same!!! 2 Reply @sandraholman1551 @sandraholman1551 10 months ago thank you for superior information on reversing againg! Reply @traceygratch95 @traceygratch95 2 weeks ago Dietary cholesterol absolutely has an effect on serum cholesterol. Most people who follow a plant-based diet so a drop in cholesterol. My cholesterol dropped significantly after switching to a plant based diet. Reply @AdisMoshi @AdisMoshi 2 weeks ago But what about the adrenals in regards to fasting? Or when you are already fasting without knowing because of stress or horrible work circumstances. Reply @JoyOnTheDaily @JoyOnTheDaily 1 year ago What a gift! Thank you to both of these brilliant scientists, Sinclair & Huberman, for being not only articulate in their thoughts & data, but also entertaining! I’m on my second listen & have shared with many friends & family. Great takeaways for living an optimally healthy, long life! 🤓♥️✨ 3 Reply @alyzimm1741 @alyzimm1741 7 months ago Question, will the nine essential amino acids supplement do the same thing? Thank you in advance. Reply @vikas_nagarr @vikas_nagarr 3 months ago Hello Mr. Huberman and Dr. Sinclair, Can we reactivate "🍖Growth plates 🍖" especially in the leg bones to increase the overall height? Reply @diegobarreto8662 @diegobarreto8662 5 months ago HUBERMAN PREPARES HIS INTERVIEWS... HE IS ALSO A DR. VERY INTERESTING! Reply @erwin_888 @erwin_888 6 months ago Comment on the first minute (before watching it all): For over 3.500 years Chinese culture knows about longevity and slowing down the aging proces by prevention, medicine and health-care. Think (but not alone) QiGong, Tai Chi, Tai Yin (Chinese Yoga), Kung Fu, acupuncture, Tui Na (massage and manual therapy), cupping, plants and herbs, and so on. Based on YinYang and or 5 Elements, An integral and holistic approach for health including reversing / slowing down aging. Just start with what resonates with you, get some intel and go from there. You won't regret it. Having said that, iam gonna watch the vid now ;-) And many thanks for Andrew Huberman for his free series on health. I've learned a lot 🙏 2 Reply @Ppomia @Ppomia 3 months ago Doc Andrew, do video on gastroparesis disease. Is there new information on how to cure it or new meditation for this horrible disease 😢 Reply @TheSheekeyScienceShow @TheSheekeyScienceShow 1 year ago I'm intrigued to hear Dr Sinclair's podcast when it comes out! It is great to see scientific research presented in such an engaging manner. 82 Andrew Huberman Reply 8 replies @Magicmaggi_13 @Magicmaggi_13 7 months ago I have a vague question. And I don’t have full clarity on this. Weight training seems to boost growth hormone production - would this mean we’re inadvertently accelerating ageing? Reply @zecatarino6548 @zecatarino6548 10 months ago Andrew Huberman, at 1:45:28 ... That machine already exists. Oberon software and interface. There are 2 competing manufacturers. It gives you huge information in minutes. Reply @bartoszkleszcz5420 @bartoszkleszcz5420 10 months ago Hi! Has anyone got the list of supplements and recipes in the podcast? Reply @sedgieroobets @sedgieroobets 4 months ago 'We should study the hypothalamus together' 😊 Reply @JaneyBrown @JaneyBrown 9 months ago "If I don't eat a steak I feel terrible" Huberman read my mind. lol Reply @stevehunt2125 @stevehunt2125 1 year ago Brilliant interview. So refreshing to have two genuinely intelligent people with such insightful questions. Also great interviewing skills not asking too many questions at once and really listening to the answers. 17 Reply @Maniahg @Maniahg 10 months ago Hi Andrew ! 1:11:48 I was wondering if you'd be willing to do a video on this topic of covering which sceince sources/media outlets who have a clearly biased agenda or if you already have would love to watch it Reply @danieloleary6947 @danieloleary6947 9 months ago Hi AH! I love all your stuff, great content, and never as a rule comment but I have a question this time. I btw, am not some nefarious troll or keyboard warrior lol, not seeking conflict, just clarity. I have an amateur interest, ever so amateur ha!, in neuro science, quantum, metaphysical, the whole gamut but I am an out and out layman. I extrapolate, do a bit more research and then act accordingly. On this basis, same process for myself, I ended up buying some Resveratrol, and began my ingestion thereof. More IF watching, more listening and learning when I came upon this somewhat bellicose difference of opinion exchange about the effects of the stuff, not just Stanfield but he one of the leading protagonists of the other perspective. Their arguments appear as compelling as Dr Sinclair's, the scientific data employed seemingly ( I am amateur don't forget!) hard to refute, and actually pointing not just to inert influences but actually to deleterious impact of Resveratrol. I have now stopped taking but I WANT Sinclair to be right lol!! Have you any view on these opposing positions? You are logically driven man, emotion not your ethos in these wonderful podcasts of yours, and your insight in relation to this I would enormously welcome and value! Thanks! Daniel Reply @jerry11385 @jerry11385 7 months ago Just out of curiosity did Dr. Sinclair tell us his age? Reply @PenelopeRyder @PenelopeRyder 10 months ago (edited) Can you do a video on hormone replacement therapy for women? I heard Andrew mention at 41:40 that HRT if done correctly can give more energy but that it has the effect of ageing the body more rapidly? Reply @Ppomia @Ppomia 3 months ago Exactly Sinclair, I don't believe others information except those whom coming doing podcasts. Reply @elizabethl3392 @elizabethl3392 1 year ago (edited) The warrior diet … great book 🙂 I loved that you referenced this book. I like the pulse idea, I naturally do this because I can’t always remember to take supplements and they last longer. So it is a positive 😊 12 Reply @jasonzayas5487 @jasonzayas5487 2 months ago I'm very very curious as to Dr. Sinclairs outlook on Semaglutide. Reply @BloomByCC @BloomByCC 3 months ago Dynamic duo right here😊 Reply @roblouzon4811 @roblouzon4811 8 months ago Does NMN have a negative effect on people with Bi-Polar? Thank you Reply @teriliebmann3491 @teriliebmann3491 8 months ago C shaped spines used to be from aging, I see a lot more younger people already there due to device use 😢 Reply 2 replies @markoglavic2581 @markoglavic2581 1 month ago Does taking NMN & Resveratrol come with any risk of negative side effects? @hubermanlab Reply @statikz3249 @statikz3249 1 year ago This has been amazing. Thank you so much Dr. Huberman! I would love to see more info or an episode on auto-immunu diseases and prevention, particularly related to the skin! Thank you so much! 5 Reply @manuelkertesz5887 @manuelkertesz5887 3 weeks ago Does anybody know if one could get rid of eye floaters through autophagy? I've read somewhere that people with eye floaters have weak autophagy. I'm wondering could that be made better through prolonged fasting? Reply @traceysundberg1940 @traceysundberg1940 9 months ago Lol...how do we explain ALL my clients in their 90s eat Candy! Bahahaha My theory is...food has changed, my 97 Lois...ate alot of fresh deer liver..so..ick😅🤣🤣🤣 Thank u for your awesome info you two!! I've watched you both separately and this is awesome 🎶 Reply @whiteloria @whiteloria 3 months ago Is Greek yogurt allowed on the anti aging diet? I like the 2G brand, but now I'm reading that dairy shortens telomeres. I've been eating one a day for years. I did buy a plant based yogurt, but the lowest sugar I could fine is 8g. Any advice on yogurt in general would be much appreciated. Thanks! Reply 1 reply @janellebrown5520 @janellebrown5520 2 months ago What about O- RH factor blood? Any info on this blood type is appreciated🙏 Reply @robinr5669 @robinr5669 2 months ago I'm trying to optimize... great words! Reply @eleanorbatson3478 @eleanorbatson3478 1 year ago The whole podcast is excellent! Weird/interesting about people ingesting Methylene blue. True story: About 9 years ago, our son was using his microscope set and had powdered methylene blue for his slides. Unfortunately, our rat terrier got into it, and knocked over and ate some of the methylene blue and caused it to get airborne. For days we found deep blue blooms of it all over our white tile floor. We took her to the vet, and found out that methylene blue is given to dogs when they have Tylenol/acetaminophen poisoning and have developed Methemoglobinemia. Our rat terrier was fine (and is still fine), though she had dyed her insides and created a lot of work for this gal. Another fantastic podcast! Learned so much! 7 Reply @JenP2776 @JenP2776 9 months ago The other interesting thing about epigenetics are the studies on how our consciousness and our thoughts, beliefs, and emotions, have a direct effect on our DNA! 1 Reply @razmiihsan8897 @razmiihsan8897 8 months ago Doing experiments on our siblings seems to fun 😂 1 Reply @BeingMe23 @BeingMe23 10 months ago The natural aging starts in the late 20s. Not to say premature aging won't start before. Reply @vjr5362 @vjr5362 7 months ago Its not his microbiome when he eats stake, it's when we don't eat certain food for a while, the body does not have the needed enzymes for it. But in 1 or 2 days the body starts to produce these enzymes again so you can eat any food again. 1 Reply @gratitudehealingarts @gratitudehealingarts 10 months ago I’ve heard also that high cholesterol can be related to neurotransmitter imbalance because cholesterol can act as a neurotransmitter. Is this true? Reply @aye7373 @aye7373 1 year ago Oh, my goodness how amazing and informative is this conversation -For me it was a class! I took notes and study every bit of it, it took me two days to actually finish watching the whole conversation. Thank you both for helping us ask the right questions, and be aware of all the goodness that can helps us do better in our health. 12 Reply @andrechequetti4048 @andrechequetti4048 8 months ago Brilliant podcast! Loved it! Where can I find a good source of NMN? Momentous supplements does not sell it…. Reply @chocopopskiller @chocopopskiller 9 months ago How do you manage the fasting if you're lifting weights and are trying to gain muscle ? Reply @Jen-M. @Jen-M. 6 months ago I have to side with Andrew on the eating steak part... lol great podcast! Reply @franciscochacon5542 @franciscochacon5542 2 weeks ago When David says that his testosterone levels were going down, I wonder if this is because of the supplements that he is taking? And is it bad that those levels are down, or should we get a testosterone booster supplement to compensate? Reply @keelyevans7692 @keelyevans7692 3 months ago 2421 your body is directly relative to the need to fast. It's done before surgery so you don't choke and die on your own vomit. It's imperative that you not eat or drink or at least 12 hours. Sometimes your doctor will have you take pills with just a sip of water, but nowadays we could give most of them. Intravenously where you don't have to swallow anything, so make sure you check with your doctor or nurse about your medicines at home or in the hospital. You don't give medicines the nurse does. That's what I'm saying. I've been in this position for a long time with the medical malpractice attorneys and the lawyers and judges stuck in the middle like everyone else. So I hate when I defame and slander anyone just like I'm tired of having it happen to me. It's actually narcissistic abuse and it was definitely happening to the police. They were getting used like puppets to start the war Reply @melisahidalgo6412 @melisahidalgo6412 11 months ago Thank you so much for all the information you provide to us!! I’m so grateful for your intellect as well as your dedication to humanity!!! 41 Reply @quaterman1270 @quaterman1270 6 months ago I'm a bit disapointed that he did not bring up the point that the effects of resveratrol could not be reproduced and were actually proven false. But I guess he did not want to offend him. Dr. Sinclair always avoided this topic and is still advertising it. I would even bet that he does not take resveratrol but advertises it because he soled the company back then 1 Reply @robertareed2294 @robertareed2294 3 months ago I'm 61 and trying to get in shape with 2 hip replacements, I'm doing ok and no longer diabetic, but I'm have trouble with my joints. They hurt all the time. I stretch, I take supplements, I exercise, qigong, HIIT, strength but my joints continue to hurt. Any suggestions Reply @AdisMoshi @AdisMoshi 5 months ago GENIUSES TOGETHER!!!!! Reply @noksuan59 @noksuan59 3 months ago (edited) In the same way eating too much can accelerate aging, I wonder if theirs a strength and muscle mass threshold where having too much also accelerates aging? 1 Reply @wikaalai4569 @wikaalai4569 8 months ago love your show i dont speak in english so good, but i have a recuest, can you speak about INOSITOL please, i heard that metformin is not good for health, and inositol does something similar. i have pocs and the only thing that help me far is inositol. and actually all the ginecologist that i had they give me anticonceptiv pills who in long term i got stones in the ovaries. really mess up. So i think is super important to talk about inositol and insuline. thanks! cheers from chile Reply @alfred6316 @alfred6316 1 year ago Great content. Unfortunately, I have to skip ads when watching but whenever I have to think about the information I let the ads run as I can't have the ads interrupt my thoughts. Also, if there was summary notes about the key topics (supplements, time of use etc) the podcast/channel will be god-tier level. Keep up the good work Dr Huberman. 8 Reply 1 reply @theherobesidemepodcast7262 @theherobesidemepodcast7262 9 months ago Question…is there any reason why you wouldn’t take an NAD supplement vs NMN? Reply @mayacayaba6874 @mayacayaba6874 9 months ago great podcast. and funny Reply @Spooky10211 @Spooky10211 8 months ago I had a 160 pounds dog, who died of none natural cause at 16 years old. Reply @00dfm00 @00dfm00 10 months ago The latest dental x-ray tech has such a low dose of radiation you don't need any protective coats or anything. It's like 1/1000 as strong as the ones from years past. 1 Reply @_christinathechemist @_christinathechemist 6 months ago Hi! I've been hearing a lot about nmn and Resveritrol supplimentation but having a hard time finding reputable companies to purchase from. Do you have any links on your site to any helpful resources? Reply @KristySRN_Yogini @KristySRN_Yogini 1 year ago I’d really love to know more about fasting and women’s health, particularly during peri/menopause. I’ve done IF once, for 6 weeks, and my hormones became imbalanced, I gained weight, and lost my hunger cues and overall appetite. My overall calories were appropriate and I was getting optimal nutrition. I suspect there was something in the particular IF pattern I was using that was ill-suited to my physiology. But I’d like the health-benefits of it. Is there any literature on IF for women in or nearing menopause? 125 Reply 26 replies @joannk5259 @joannk5259 9 months ago He looks fantastic. I wish I could see how young his dad looks. Reply @erwinrogers9470 @erwinrogers9470 10 months ago Love it 🔥 Reply @leahannwhite1111 @leahannwhite1111 4 months ago Age is imagined. 💞 1 Reply @neilgelinas9926 @neilgelinas9926 10 months ago I juiced for one year I lost 70 lbs and I had given up all meat except for fish. I was eating only once a day when I was 39. I felt better than when I was in high school. I am now 47 and overweight, and I feel the worst that I ever have. Time to go back to the natural life. Eating by juicing 3 cups of juice. 3 cups of my water keffer. Reply @techwithdipufrom0ton621 @techwithdipufrom0ton621 7 months ago "Hunger is a tool for anti aging" but can't hunger for an extended period of time cause gastric problems and stomach ache debilitating the stomach ache? Reply @Shepard2295 @Shepard2295 1 year ago I could listen to you both for hours! Videos like make YouTube worthwhile. 23 Reply @TEEANVEE @TEEANVEE 4 months ago Could someone help me understand the cholesterol part? Is good cholesterol bad or not? How do you get bad cholesterol if not from food? Reply @jane907 @jane907 3 months ago I've gotten so used to not eating breakfast that I do intensive 1-hour CrossFit workouts on an empty stomach. If I eat before 8am then I get sluggish and need to take a nap. So when I need to sleep in, I wake up, have a snack and go back to bed. Reply 1 reply @kosisochiifediba4709 @kosisochiifediba4709 5 months ago I assumed this man was in his 30s. He was 52 at the time of this taping 1 Reply @alinao625 @alinao625 8 months ago I thought the myth of resveratrol’s efficacy in longevity was debunked a few years ago. Reply @marilyngilman5666 @marilyngilman5666 10 months ago I try to extend the time I eat breakfast past the time of feeling hungry. A little uncomfortable but manageable. then I use Fastbar by L-Nutra. Iits a fasting mimicking 200 Kcal breakfast. I take all my supplements first thing on an empty stomach and have for many years. Reply @dalendaghouthi9967 @dalendaghouthi9967 11 months ago One of my favourite episodes from you Dr. Huberman. This is cutting edge stuff. The extent to which we can manipulate our inherited bodies is mind blowing. At 39 I am looking to research further with a view to exploring some of these health protocols for myself. Thank you so much for making these science-backed tools available to the general public. Oh and a proud day for Argentina :) 13 Reply @karenvantuyl901 @karenvantuyl901 3 months ago Any info on over methylation. I personally have done the testing and came back as a over methylator. Any tips? 1 Reply @randyk7699 @randyk7699 7 months ago Andrew...is so mesmerizing Reply @primitivadizor51 @primitivadizor51 8 months ago Thank you, from Philippines. God bless. 1 Reply @s.a.l.450 @s.a.l.450 8 months ago Does NMN stand for Nicotinamide? I can't find it sold, only the NAD seems to be easily available for sale. Reply @havelife @havelife 9 months ago Awesome, awesome video. Reply @JeffNixonComedy @JeffNixonComedy 1 year ago Just finished reading Lifespan last night and now waking up to this podcast. Pretty sure this means I’ll never die. Hell ya, time to get into hobbyist sky-diving! 47 Reply 3 replies @rarebird_82 @rarebird_82 7 months ago (edited) Sorry, WHAT? I had to rewind that... did he just say he's 52?! This man does not look a day over 30! Since turning 40 six month ago, I've become much more mindful of my overall health, I've increased excercise, put more thought into my diet, my sleep habits and cut out alcohol (having reduced from drinking 2 nights a week, to 1 night, to once a fortnight, to once a month, to once a quarter). I'm naturally slim and have never eaten more than 2 meals a day, usually just 1. Dr Hubermans podcasts have had a real positive impact on my life, and this one didn't disappoint. Thank you gentlemen 🤍 1 Reply @danielgarza1810 @danielgarza1810 10 months ago Anytime I have done intermittent fasting I would get shaky if I had any caffeine and without caffeine I would feel sluggish typically and I would go back to food before reaching any ketosis, was going to try nutritional yeast and supplements but then lost my job, got depressed about it and developed a bad drinking habit and my new job doesn't pay well. I gained 50 lbs, trying to quit drinking and struggling to do so and I am willing to try anything to regain health but I don't make much money & soon as I feel nauseous I go for what works to prevent vomiting but I don't know what I could do better....IDK. I have quit smoking cigarettes a year ago and I don't understand why I struggle more with this or how to lose weight I gained. I wish I had a health coach or something. Reply 1 reply @ismailvally118 @ismailvally118 10 months ago Can one take a small dose of Metformin..eg..250mg after breakfast. Would that help? Then gradually increase to 500 or more Reply @bemydinosaur13 @bemydinosaur13 8 months ago I’m not so sure about “skip a meal a day” being good advice whew. Eating disorder experts literally look for that as a sign of serious disease and in your treatment plan, consistently eating 3 meals a day will be a goal you have to hit in order to finish treatment. Fasting now and then is one thing but skipping a meal every day will land you at an inpatient mental health treatment facility Reply @enriquegonzalez9434 @enriquegonzalez9434 8 months ago "he just called me poor" - "woman can take it too" 😂😂🤣 1 Reply @jezebellab1779 @jezebellab1779 1 year ago Best ever. I nerd out trying to figure out my ADHD brain and my genetics from my 23 and me data through other companies. I’m a 51 yr old female and people think I’m 35. I’m so signing up on Dr Sinclair’s website!! Thank you for this amazing podcast!!! 9 Reply 3 replies @CharlotteFairchild @CharlotteFairchild 10 months ago I turned the sound on slow, and fell asleep the first time I played this. Knotweed is not kudzu, which I know much more about than knotweed--a relative of buckwheat. I take many supplements and few minerals and I am over 60. My father had no grey hair until he was 69 and had a heart attack. I wish Dr. Sinclair could study Andrew B. Chung, MD/PhD. He measures the Omer and eats few greens. He bicycles much more than he drives. He was trained as a cardiologist and geneticist from Emory. He lives in Mapleton, GA. Are either of you colorblind? I would like glasses that do not break. I am not colorblind. Reply @danarosesturgeon @danarosesturgeon 2 months ago freaks....age isn't a disease. Growing old gracefully can happen if you take care of yourself. You don't have to make a cult out of it. My granny lived to be 105. She was a hard working ranch wife and everything they ate came from the ranch. They also drank quite a bit of whiskey about once a month. 1 Reply 1 reply @denny3161 @denny3161 8 months ago Regarding Methylene Blue, Dr.Mobeen Sayed has a recent video on it. Reply @00dfm00 @00dfm00 4 months ago Sinclair's research into resveratrol resulted in a paper in 2006. Since then, there has been a lot more research and they show that resveratrol is useless - at best. Yet, he still keeps going on about resveratrol as though all that research never happened. I kind of wish Huberman would push back once in a while or do a minimal amount of challenging in these conversations. After all, isn't this program supposed to be exploring the latest health information with the best unbiased information? I'm feeling a bit let down from both Sinclair and Huberman right now. :( 2 Reply @JasherOne @JasherOne 10 months ago I will believe in reversing of aging when he will make the interview with a baby 1 Reply @captiongeeza @captiongeeza 1 year ago Makes me proud as an Aussie to see one of our own, an expert in his field mixing it with the best in the world 👍🏻 32 Reply 3 replies @Anleifr @Anleifr 10 months ago Hi, I am curious if Protein Powder is OK to take to hit the bodyweight = amount of protein one who works out is supposed to get? Reply @monagallant9141 @monagallant9141 3 months ago Yes, I regularly eat fish & seafood at least once a day. And very occasionally eat meat, pasta. processed foods. So now I shall be OK, not concerned if I don't eat before 4 pm. I do have my coffee in the morning, could have more tea though.. I am 67 yo. It has taken this long to let go of the programming I must EAT 3 meals a day. I am rarely hungry until the evening. 2 Reply @somedandy7694 @somedandy7694 3 months ago Getting older is inevitable. Getting old is not. Reply @DinkaPignon @DinkaPignon 8 months ago (edited) At 51:07, Dr. Sinclair says: "Pure Resveratrol should be light gray or white in colour. If it is brown, throw it away because it has either gone bad or is contaminated." The Natural Factors' Resveratrol (capsules) that I just bought is brown. The exp. date on the bottle is April 2025, so it's supposed to be good. Natural Factors is a reliable manufacturer and Dr. Sinclair is also to be trusted I suppose. ??? Any advice from anyone? Reply @TS-nb5mb @TS-nb5mb 10 months ago Very interesting, thank you. one thought, the Southern Ocean whales, have a lifespan of 150 years,.. are quiet large... Reply @MMyL7 @MMyL7 1 year ago (edited) OMG. JE SUIS TROP HEUREUSE QUE CETTE INTERVIEW AIT LIEU 😭 MERCI Perfect end of the year, best wishes for this podcast, its crew, and all of the viewers that are interested in science. 🥳 23 Reply @user-vn9pf7dh6e @user-vn9pf7dh6e 10 months ago What is the effect of fasting on women who have PCOS? It is a hormonal disorder that is linked to insulin. I am always told to eat regularly Reply @kathyscott8009 @kathyscott8009 7 months ago How about women in their last 60s and intermittent fasting. Any good articles or books out there to read with re to this. I was doing intermittent fasting for a few months to the best of my ability but found it can cause some disruptions in your BMs Other than that I found it quite easy!! Reply @goolsbycf @goolsbycf 9 months ago If I am taking bioidentical testosterone (I’m post menopausal)will metformin lower my levels? Reply @s.a.l.450 @s.a.l.450 8 months ago Is the recommended supplement NAD3 or NAD, or liposomal NAD+ ? What is the full name of NMN? Reply @markl1617 @markl1617 5 months ago Be fasted, live to 150 but be weak as a kitten and vulnerable to attack. Ludicrous 2 Reply @waynewestly4468 @waynewestly4468 1 year ago This podcast was/is just simply jaw-dropping. Very very well done. I as others are so appreciative of your efforts to communicate your insights in ways that are understandable and actionalbe. Thank you!! I am hooked and on board. 25 Reply 1 reply @bridgette7980 @bridgette7980 9 months ago Can you do an episode on impact of heavy metals and how to remove them from body ??? Thank you Reply @sakshiupadhyay2816 @sakshiupadhyay2816 9 months ago Does this also answer that most of the yogic lifestyle practices are based on intermittent fasting eating once or twice only . We need more research on them as well Reply @jimstretch6109 @jimstretch6109 10 months ago I've heard that metformin can cause muscle wasting Reply @davidfarrall @davidfarrall 6 months ago You can build your serotonin, dopamine-use, neurotransmitters, hormones and enzymic activity at any time in life. You find your own life support factors over time by empirical means and coping mechanisms, alleviating a lot of mental illness as well. Reply @josephcaprino6096 @josephcaprino6096 10 months ago It took you 8 minutes to describe one man someone pays attention to detail Reply @treyd3433 @treyd3433 1 year ago Stuff like this is a representation of some of best attributes of our species. Thank you doctors for sharing your knowledge!! 28 Reply @cherriecarse3389 @cherriecarse3389 8 months ago Dr. Huberman, I enjoy your podcasts so much. I wonder what is the story about taking NMN now? I recently tried to order from Momentous. I have some from another lab but did not understand why Momentous gave me an answer which was convoluted when I questioned them. I know I feel better when I take NMN. Please advise. Cherrie Carse Reply @zvndmvn @zvndmvn 6 months ago Two high quality humans full of valuable insight right here. 👌 1 Reply @jossylopes @jossylopes 8 months ago The Good Doctor Reply @bobgibby9292 @bobgibby9292 9 months ago David Sinclair—same category as mr gates.....scammers.....stay the course Andrew —biology , your better than the people you sometimes interview 1 Reply @ifnotnowthenwhen9063 @ifnotnowthenwhen9063 13 hours ago I AM 1/4 of the talk And i AM fascinated that ithis info can be stare with us. Reply @belkisalvarez2085 @belkisalvarez2085 1 year ago What fantastic information you share with the public. This is invaluable. Thank you very much for the work you do and the impact it has on the human race. 4 Reply @Livefreeman @Livefreeman 9 months ago (edited) I don't understand why not just take nad instead of nmn when nad is deficient. What's the advantages of nmn over nad? I am trying to decide whether to buy nad or nmn? What's the difference between nadh and nad, which supplements do you recommend Reply @monagallant9141 @monagallant9141 3 months ago OK... here I am feeling guilt that I am NOT taking my supplements everyday! So relax. As I am older, I take glucosamine, collagen, calcium (incase my bones and teeth grow at my age...?) and the usual vitamins. 1 Reply @savssavs8559 @savssavs8559 10 months ago That joke about the bath 😂 Reply @scuttarockz @scuttarockz 9 months ago Wish for every videos , there will be a summary of actionable insights for the audience who do not understand what all the medical terminology means :/ Reply 1 reply @megmckinney7254 @megmckinney7254 3 months ago I need this thank you 1 Reply @YEE087 @YEE087 1 year ago Thank you Andrew, what a great episode. You've asked the questions that I've been thinking about over the last few years since I first listened to David. 4 Reply @0121bassline @0121bassline 8 months ago I researched that liposomal nad+ is better than NMN or are they the same thing ? Reply @LorinaCoble @LorinaCoble 9 months ago I would really like to know who he buys his Resveratrol and nmn from. So far on anything I've listened to he's never told. Reply @SMcC501 @SMcC501 3 months ago I shall not spend my days trying to prolong them; I shall use my time. Reply @celestesenters1052 @celestesenters1052 10 months ago I grow a big garden every year. I love gardening ❤ Now I’m going to stress my plants more Reply @edmund_teoh @edmund_teoh 6 months ago (edited) 1:02:35 protocol ~ 1000~2000mg nmn + 1000mg resveratrol + metformin 1 Reply @diedinky1358 @diedinky1358 1 year ago (edited) G'day ! I learnt SO SO much about the science and mechanics of our amazing human body - I thank you both SO SO much for your endless pursuit of knowledge in this field (you've worn out your trousers studying this subject at school desks over years!) - I thank you both SO SO much for the candidness of your deliveries - it motivated me SO SO much to lower my biological age - I thank you SO SO much for giving me hope for better health - G'day ! 4 Reply @TheSparkle45 @TheSparkle45 3 weeks ago Would be interested in knowing if there is anything you take to retain hair colour? Thank you in advance, much appreciated. Reply @gary_michael_flanagan_wildlife @gary_michael_flanagan_wildlife 10 months ago When you are watching a podcast on longevity and you get a casket, funeral commercial…😂 Reply @techwithdipufrom0ton621 @techwithdipufrom0ton621 7 months ago Is the reverse aging pill on the market yet? Reply @yowaiomae914 @yowaiomae914 3 months ago 1:15:00 we need to personalize med as everyone is different Reply @nicolatesla5786 @nicolatesla5786 10 days ago I got blocked from using YMCA because I was telling three random young people in a Jacuzzi about the long term health benefits of delaying aging and extending the life span. Reply @lovnmyworld1922 @lovnmyworld1922 1 year ago I am only in 18mins and This conversation is so interesting between two great educated minds. I am hooked, love it already Oh and NOT drinking alcohol is definitely not boring AT all. Love it 24 Reply 1 reply @frugalcooking523 @frugalcooking523 6 months ago It is named communication noise and the recipient may end up sometimes with something totally different. Reply @melaniel7263 @melaniel7263 6 months ago Highly informative podcast but I’m trying to get body language cues from the arm crossed over the chest. 😂 Nerves, hesitancy maybe? Reply @DJ-zm5qb @DJ-zm5qb 9 months ago He just HAD to clarify it was “two” different ice baths. They weren’t in the same one “just to be clear” 😂😂😂😂 Reply @SrtaLuizaLou @SrtaLuizaLou 5 months ago The dude looks 40 at max but he’s 52. That’s quite amazing. Reply @crono21three @crono21three 9 months ago This guy says he is 52 and looks better than me (36), he got my attention. Reply @jamiemason7423 @jamiemason7423 1 year ago Really, really enjoyed this. I'm curious now about cycling or "pulsing" my supplements. I've had this instinct that perhaps I don't need all of the things every single day and part of your discussion seemed to hint at that. Perhaps Dr. Sinclair will talk a bit about that in his own podcast. Thanks for your wonderful podcast! 6 Reply @JenP2776 @JenP2776 9 months ago Because berberine has been found to be almost as strong as Metformin, I would think that it would be a more safe, natural, and healthful alternative. Reply @gailkoelmeyer7650 @gailkoelmeyer7650 8 months ago What are the supplements( athletic greens?) that David has in the morning with yogurt? Reply @Alvinytt @Alvinytt 6 months ago To get to the root of a problem, question everything, including your perception. Reply @Jonjonjonny @Jonjonjonny 1 month ago Fasting spikes growth hormone production. So if growth hormone speeds up aging as Dr. Sinclair stated surely it would counteract fasting’s anti-aging benefits to some degree no? 2 Reply @motheofbean @motheofbean 10 months ago Would like to work with you Dr Huberman🙏🏻❣️ Reply @paduraruovidiu201 @paduraruovidiu201 1 year ago I believe this is the 7th episode I'm listening to, in the past 4 days. Thank you again, Mr Huberman! 33 Reply @KA-ux3tz @KA-ux3tz 10 months ago Dr Sinclair says he supplements every other day then said he takes 1000mg resveratrol per day...? Guess we have to fiddle it out for ourselves Reply @jjp3515 @jjp3515 10 months ago My grandparents are well into their 90's now and I wouldn't wish it on my worst enemy. People should not live forever. 1 Reply @deborahpiquant2523 @deborahpiquant2523 4 days ago I also gave up sugar and its true, your teeth will thank you, a great unexpected benefit! Reply @pebblepuds5163 @pebblepuds5163 4 months ago I know that whatever he says is scientifically backed up and as someone pursuing research in dna damage repair, I understand his claims but the media we consume and everything propagating 3 meals a day and so many things about nutrition is just refusing my pea brain from accepting what he’s saying. Damn it’s weird to see how hardwired we are… Reply @ftakenouchi1464 @ftakenouchi1464 9 months ago No meat. No sugar no alcohol yes those are bad and everyone is diff yes we hear you. At end of day people: everything is okay in moderation, listen to your body always and adjust accordingly, and don’t forget to LIVE socialize and importance of emotional health…find a purpose. Reply @marcuslehman670 @marcuslehman670 1 year ago (edited) An MD/MBA/explorer here...a lot of joy for me comes from excellence in various domains, so I've really enjoyed this podcast series for the great introductions to content! I struggle when it comes to application to real life: would love to talk to the marathon runner mentioned--long workouts or athletic success of any kind would be very hard to do without eating for major phases. And then you add in all the other great podcasts! Maybe a future podcast on integration of different podcasts would be interesting i.e. hot is good, cold is good, exercise good, fasting good, speeding recovery...how we do it all for long enough to learn what works while juggling the hospital, relationships, etc...hopeful thoughts, not critical ones! Any suggestions appreciated! 3 Reply @CollegeWebMag @CollegeWebMag 8 months ago I keep coming back to this. Today, I have two words: KEITH RICHARDS. Reply @gloriagolemboski4515 @gloriagolemboski4515 7 months ago How do you fit in calcium, d3, K2/m7, magnesium,zinc, fish oil etc. which I take lots of vitamins due to osteoporosis , had melanoma so need highD3 because I don’t go in sun. So if I add resveratrol and NmN 100 each per day how do I fit it in. I would appreciate your answer that any people who won’t or can’t take drugs for osteoporosis need these vitamins. 😊 Reply @vinzecerda4833 @vinzecerda4833 3 months ago Huberman : he just called me poor Dr Sinclair : women take it to 😂😂😂😂 Reply @warriorinchrist9585 @warriorinchrist9585 9 months ago The Western diet that doctor Sinclair refers to I really like to call the bellious ogatis disease. Lol Reply @emilklingberg1623 @emilklingberg1623 7 months ago Its interesting what he says about diet coke, because all my friends who drink that kind of stuff are really unhealthy and fat. 1 Reply @markanderson8146 @markanderson8146 1 year ago As a fit and active 67 year old this was the podcast I was waiting for! Great listening to two experts working at the cutting edge. I have wondered about the apparent conflicting avenues of maintaining or even increasing muscle size as one ages (activating the mTOR pathway?) versus apparently living a longer healthy life by shutting down the mTOR pathway. It appears that if one goes all out trying to increase muscle size through an appropriate exercise program and ingesting supporting levels of amino acids such as leucine a person is actually increasing the risk of aging faster. It seems so contradictory to be trying to reduce muscle loss as one ages yet at the same time trying to extend healthy lifespan. By my understanding Dr Sinclair is effectively suggesting that you have to forgo maybe a little peak muscle performance in order to gain the "longevity" benefits of the supplements and compounds he personally uses. Happy to take comments on this 28 Reply 6 replies @theobserver9131 @theobserver9131 5 months ago I'm kind of tripping out on seeing someone built like a mountain speaking as a scientist. It's a cool juxtaposition! :D Reply @Ninfarose @Ninfarose 10 months ago So beautiful sublime ❤️ 🥰 Thank you so much ❤️❤️🥰🥰 Reply @guillermopadilla5840 @guillermopadilla5840 3 months ago Love you guys ❤❤❤🎉 Reply @33Treez @33Treez 9 months ago Better "indexers and Oracles" in the body is needed 🙌 Reply @yolandagrabowski6043 @yolandagrabowski6043 8 months ago Good for you for not consuming alcohol! Reply @isabelleebel8552 @isabelleebel8552 1 year ago What a great episode! Thanks so much for (finally) bringing David Sinclair to the show! One question that I have been asking myself for a while now and it seems that there is not much out there about this (yet): When it comes to Menopause, is it good for longevity if menopause starts early in life? As we see this often when women eat too little or do strict IMF and thus have less or too little „Storage“, therefore their period stops early, is this good or bad and what are the recommendations here? Are there differences between sexes that need to be further considered? I am missing this in the conversations about Longevity and IMF and would love to get your opinion on this! 16 Reply 1 reply @StrongwillGameTheory @StrongwillGameTheory 4 months ago How abt fruits, do yo let it over ripe or slightly rot a bit? Does that activate resveratrol? Reply @danielgarza1810 @danielgarza1810 10 months ago I would gladly be a lab rat, so to speak, with regard to trying supplements to rejuvenate. Reply @BeingMe23 @BeingMe23 10 months ago We can only slow down aging. It can't be stopped. Every species of Animals have a life span. Reply @fncr070 @fncr070 4 months ago I like caloric restriction, and even fasting here and there. But, if you’re regularly training, not eating all day is a recipe for disaster. Reply @cindybecker4725 @cindybecker4725 8 months ago What are the blood test they recommend ? They mentioned HGBA1C and CRP. What else ? Reply @chadboy5385 @chadboy5385 1 year ago May God bless you Andrew Sir.You are like modern Prometheus,bringing flame of knowledge to us. 6 Reply @ivapetrova4447 @ivapetrova4447 3 months ago I have a question- is eating red meat or meat in general speeding the aging process? Is it best to avoid red meat ? I was told it’s essential to our wellbeing? Thanks Reply 1 reply @enkibumbu @enkibumbu 8 months ago Sinclair looks a fair bit better than I do! Reply @rahulvaidya6753 @rahulvaidya6753 1 month ago (edited) David Sinclair is 53 years old... he literally looks 30 Reply @elisalatkovich4704 @elisalatkovich4704 8 months ago We were designed to live forever..just saying❤ Reply 1 reply @Fummins139 @Fummins139 10 months ago Time stamps please! Reply @Professional-ki2uk @Professional-ki2uk 1 year ago This is what every Science fan would love to attend. Thank you so very much Dr. Huberman for your extraordinary efforts. Keep going 3 Reply @TheWisdomOfTheAges_PsyM_Revd @TheWisdomOfTheAges_PsyM_Revd 9 months ago (edited) 45:00 Berberine is the poor man's form of Metformin, thank you for this. Reply 3 replies @AnnKrilanovich @AnnKrilanovich 10 months ago Do you find Metformin research (and longevity) credible? Reply @davealan2541 @davealan2541 2 months ago From David Sinclair face looks he’s 35 but in fact he’s 51. This means what says working for him 1 Reply @christylabrentz2984 @christylabrentz2984 7 months ago Can you post a link to the supplements (Resveratrol, NAD, NMN, NR) that Dr. Sinclair takes? I am feeling lost on where to source them. Reply @francishiraldo9313 @francishiraldo9313 12 days ago Listening on the treadmill now ❤ Reply @guidoaxmann5167 @guidoaxmann5167 1 year ago As an MD I am enjoying your amazing work greatly, Andrew. Thanks a lot. As trust and consistency matter when it comes to cutting edge science and innovative medical protocols, I have a question, which you could help clarify. In this episode (#52) David Sinclair says @ minute 87:28 (check transcript): "I don't take multivitamins". In his recently started podcast, which you announced earlier, he promotes sponsor Athletics Greens claiming that he drinks it every morning for a few years. As Athletic Greens clearly classifies as a multivitamin we could face an inconsistency, which we should overcome. I left David a comment on his show to clarify and perhaps you want to pick this up as some followers listen mindfully and we do not want to erode trust in the overall science being so carefully presented due to a promotional inaccuracy. Thanks! 14 Reply 4 replies @curiouskittycat5977 @curiouskittycat5977 9 months ago I don't have any plaque and have never had it! I am abs convinced it is foods choices the most and the regular teeth brushing... food mainly. Reply @user-gz2hl7qt6o @user-gz2hl7qt6o 8 months ago I recently listened to your conversation. I wanted to share some information that may be of interest to you. Research papers indicate that niacin does increase NAD+ in both muscle and blood, but the effect may be dose-dependent. In a study conducted by Pirinen et al, blood NAD+ increased up to 8-fold, and muscle NAD+ of patients reached the level of their controls when they administered an increasing dose of NAD+-booster niacin (750-1,000 mg/day) to patients and their matched controls for 10 or 4 months, respectively (Cell Metab. 2020 Jun 2;31(6):1078-1090.e5). Similarly, in another study by the same group, a dosage of 100 mg of niacin did not significantly increase NAD+ levels, while a dosage of 500 mg increased NAD+ by 5.6-fold. These findings suggest that NAD+ production may indeed be dose-dependent. Although I am not an expert in this field, given that niacin is one of the precursors of NAD+ and the historical success of Vitamin B3 in treating Pellagra and mitochondrial myopathy in patients over the past 40 plus years, it seems reasonable to expect that Vitamin B3 supplementation could increase NAD+ production in the muscle and blood. I greatly respect and appreciate your public health education podcasts and would love to hear your thoughts on these findings. Eun-Hee (Park) Cirlin, Ph.D. 1 Reply @findthecheese3692 @findthecheese3692 1 month ago If I don't eat a steak I feel terrible. -Dr. Andrew Huberman 1 Reply @DigitalRaider1 @DigitalRaider1 9 months ago (edited) Yea, I have a problem with Metformin blunting muscle growth. As a person who goes to the gym 3-4 times week actually wanting muscle gains (they look better)...I dont like the effect of Metformin on that. 1 Reply 2 replies @amna378 @amna378 8 months ago thank you ❤️ Reply @susanwoodley8171 @susanwoodley8171 1 year ago Thank you! Glad to see you two together in this interview. Question: You talk about how dietary cholesterol doesn’t influence blood cholesterol - how can a person control their blood cholesterol without diet or statins? For future episodes: 1. As mentioned above, I’d love to hear more about dementia and how to prevent or slow it based on current day research. 2. As a menopausal woman, I’m always wondering how a lot of what you talk might impact me differently. So I’d love to hear an episode talking specifically about women’s health, hormones, aging, etc and maybe have someone like Dr Jen Gunter to debunk myths and stray from the patriarchal world of medicine. Thank you for bringing us accessible and brilliant science that is so relevant to our lives. 22 Reply 2 replies @kapekacava @kapekacava 10 months ago This is interesting, but I believe met Forman being a chemical is not good for somebody to take. I think it’s best to just exercise every day instead of taking met Forman on a day that you might not exercise. 1 Reply @StephenOrion @StephenOrion 9 months ago If this dude is 52 and looks like this, I’m going to have whatever he’s having lol Reply 1 reply @frankierebekah @frankierebekah 10 months ago Which nmn should I get & can I take a nad instead of mnm has anyone heard of tru niagen Reply @carrieg8779 @carrieg8779 4 months ago Bernerine is as efficacious as Metformin. Reply @bobbibullock1433 @bobbibullock1433 3 months ago Dr Hubermqn I want to know what you think of cryotherapy? I respect your opinion Reply @yakan01 @yakan01 1 year ago This is the perfect episode for the new year! Love this podcast because it cuts through the deluge of information, much of what is misleading or just plain wrong. Already subscribed to InsideTracker and have found my biological age is elevated... so there is some work to do. As for future episodes, can I put Parkinson's on the list? Like Alzheimer's, it's a terrible disease that's more common as we age and that devastates so many families. 6 Reply @lawrencefitzgerald @lawrencefitzgerald 3 months ago two good companies, Thorne and ProHealth Longetivity 1 Reply @joanchapman6219 @joanchapman6219 8 months ago (edited) What are your thoughts on the FDA ruling banning the sale of NMN in the USA? Are we going to be able to find this supplement? 1 Reply 2 replies @callumraine4100 @callumraine4100 8 months ago Does taking creatine increases aging? Reply @debbiedebbie9473 @debbiedebbie9473 8 months ago (edited) 37:58 AMINO ACIDS DOES LUCINE CAUSE AGING ? 40:00 Aurie Hoffneckler (so) ? Fasting and pulsing, nourish the body, boosts vitality. Reply @myyoutubechannel506 @myyoutubechannel506 2 months ago I'd love to know if these guys took the clot shots 💉 1 Reply @armasconi @armasconi 1 year ago (edited) Incredible podcast, truly a breath of fresh air. You and David have an amazing dynamic together! 6 Reply @young_rich @young_rich 4 months ago Why not take the NAD itself then? Instead of NMN? 2 Reply @runninghighOG @runninghighOG 2 months ago Please have Dr. Francisco Gonzalez-Lima on to talk about Methylene Blue. He's also a neuroscientist and has been researching MB for decades. When you laughed at people and said that they should see a psychiatrist for using MB b/c they most insight you have about it was you used it as a kid to clean your fish tank, you sounded no different than Don Lemon on CNN referring Ivermectin as horse paste. 1 Reply @rachelrobertsmeditation-mo9456 @rachelrobertsmeditation-mo9456 1 month ago Hi I'm not sure if you can help or if you will ever recieve this comment. I have only just started taking st johns wort, primarily to help stabilise my emotional state as I fluctuate transitioning through peri menopause. I'm really interested in taking resvertol. My question is will they interfere with each other? I appreciate any feedback thanks. X Reply @manmustbuild @manmustbuild 10 months ago Hasn't the science behind Resveratrol been basically debunked? Reply @username8771 @username8771 10 months ago But aging cannot possibly be stopped. People are mortal. 1 Reply @andresfernandez304 @andresfernandez304 1 year ago They really took us to school on this one. Had to rewind and research often. Great job. 9 Reply @leilaali6041 @leilaali6041 4 months ago metformin is also great for women with PCOS better alternative to birth control, especially if you're not sexually active Reply @stefdiazdiaz7067 @stefdiazdiaz7067 10 months ago How saturated your cell membranes are also predict longevity since it makes your cells more resistant. That is why seed oils are such a bad bad idea... Reply @shanadido @shanadido 1 month ago (edited) Dr Sinclair looks 35 not 53-he must've followed his own advices...:) Reply @surferdudemi @surferdudemi 8 months ago Aren't airport scanners millimeter wave devices, not x-rays? The stuff on the belt gets x-rayed. Millimeter waves supposedly do not penetrate the skin Reply @bobbybouchey4122 @bobbybouchey4122 8 months ago Why is it literally everything andrew or his guest recommend can never be bought from a reputable vendor. I'm from uk biggest supplement store is Holland and Barrett and dont stock anything , NMN, resveritol, magnesium threonate, theanine, tong kat ali, fadogia agresis. 2 Reply @meimei2630 @meimei2630 1 year ago what a time to access knowledge, narration as easy as it gets and being accessible to those who seek!! thank you. 6 Reply @RigemortisTheGoth @RigemortisTheGoth 4 months ago This is great but does this guy train? I am interested in the benefits or disadvantages to 24/48hr fasts when you are weight training and not taking in any nutrients to repair what you have damaged. Also it would be nice to have this guy film every second of his week to prove his claims of long weekly fasts, as when it comes to diet it is SO easy for people to lie. Reply @markgoslett6334 @markgoslett6334 4 months ago Has anyone from the UK done the research and found reputable sources of Resveratol and NMN in the UK? Something about Amazon doesn't fill me with confidence Reply @artikhandelwal7291 @artikhandelwal7291 5 months ago Please do a podcast on skin. Reply @irenadurakic-edwards9577 @irenadurakic-edwards9577 1 month ago I watch this obviously much later but im just getting into this and Dr Sinclers work and my question is-Why,if they found that mice(or rats) on normal diet who took every day resveratrol didnt have prolonged lifespan,but those who were given it every second day did,why than Dr Sincler takes resveratrol every day? As far as i understood only mice on high fat diet had prolonged life when getting resveratrol every day.But dr Sinclairs far from living on high gat diet. Im asking as i plan to do interminent fasting now,so,based on those results,should i or not take resveratrol every day as Dr Sinclair or not?🤔 Reply @askerali5794 @askerali5794 9 months ago I wanna do dna test in kerala india. Where is it available Reply @rajitakumar8811 @rajitakumar8811 1 year ago This is amazing and am glad i found this. Two great minds in conversation and so generous ! The best experience in life i am having getting this knowledge 4 Reply @dominicmutzhas6002 @dominicmutzhas6002 8 months ago Wouldnt it be better to much eat in the morning and Not or little at night? Circadian benefits wise? Reply @brandonframe7159 @brandonframe7159 4 months ago A year of inside tracker is over $2500. I don't think someone cutting back at starbucks is going to be enough to absorb that cost. I am all for the idea of people getting their labs from home but the pricing has to come down drastically. Reply @rosenguyen4181 @rosenguyen4181 8 months ago 👏👏👏👏 Reply @Tizoc85 @Tizoc85 9 months ago I love the information but I would rather look like Dr. Layne Norton than Dr. Sinclair. Ideally a combination of both depending on your goals in life would be nice. I think feeling positive about yourself while having the physical strength and intellectual capacity to help others may also have a positive benefit along with a mind set of gratitude. Reply @DG-kr8pt @DG-kr8pt 6 months ago 1:12:18 Thank you for recognizing that both men and women can menstrate. Reply @breathbodybalance3695 @breathbodybalance3695 1 year ago What a wonderful gift for this new season! Thank You For sharing what many of us are discovering to be the most valuable information for our species!! I learned many years ago to be the best in the world to really hone in on the basics of that particular skill because the basics build a solid foundation for us to launch from. Thank You for basically sharing this incredibly valuable information, you are truly the best in the world at what you are doing!!! Thank You 🙏🏼 May Much Love & Many Blessings continue to flow through you and us as we become healthier individuals all together 🌀🙏🏼🌀🎁🌀🕊♥️😁🌀🙏🏼 🌟🤩🌟 🌀 ⭐️⭐️⭐️⭐️⭐️ 4 Reply @keymonkey1230 @keymonkey1230 3 months ago im confused, how come fasting is good for slowing down aging when fasting stimulates growth hormes? 1 Reply @johntl4503 @johntl4503 5 months ago He said death comes fast at the end of life. It sounds like he is optimising health at the expense of his bodys mechanism. 1 Reply @JamesBond-wg6ov @JamesBond-wg6ov 7 months ago