lifespan review

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it. top positive review Positive reviews› Jim 5.0 out of 5 starsoutstanding book Reviewed in the United States on December 6, 2023 This book is as close to the truth about aging as it is possible at this time. There is an enormous amount of wisdom in this book. There are many things in here that will help a person live a more healthful longer life. It is a very optimistic book about the future of our health care and the human condition. You can learn some biology. The author is very knowledgeable and at the top of his profession. Everyone should read this book. Top critical review Critical reviews› mofolotopo 3.0 out of 5 starsGreat while it sticks to the biology Reviewed in the United States on July 16, 2021 I found approximately the first half of this book to be really fascinating - a great overview of the current state of the art and near future of anti-aging research. Once it gets to the societal and environmental impacts of longevity, though, the whole thing goes entirely off the rails with Sinclair basically just wishing away massive societal issues and hoping for the best. In particular the bit where Sinclair fantasizes about people staying in leadership positions is extremely poorly thought out, to the point of being infuriating. For every person in a position of seniority who does not retire there is a younger person (or more than one) whose career advancement is put on indefinite hold. One would think this would be fairly obvious to an academic - a career where this exact issue is the bane of early career researchers everywhere. If you can't think of a better answer than this, all of your attempts at life extension are going to fail because the young people are going to realize that there will be no opportunities until they start shoving the old people off of the nearest cliff. More generally, however, he shies away from any solutions that might seem too extreme (e.g., with respect to the global distribution of wealth), and resorts to vague handwaving about how everything has always worked out in the past. That's not particularly convincing in any line of argument, but in particular it's not convincing when you've just spent half a book arguing that the future isn't going to look anything like the past. I think these choices are largely made to make the book palatable to a broad audience, because I suspect that Sinclair is smart enough to know that a revolution in aging is going to require, or even precipitate, some profound changes to our society. Anyway, it's worth a read but honestly you can stop right after he covers his daughter's concerns with his research. If the rest of the book is any indicator, she's right. Read more 13 people found this helpful Search customer reviews Search SORT BY Top reviews Top reviews FILTER BY All reviewers All reviewers All stars All stars Text, image, video Text, image, video 10,284 total ratings, 968 with reviews From the United States Jim 5.0 out of 5 stars outstanding book Reviewed in the United States on December 6, 2023 Verified Purchase This book is as close to the truth about aging as it is possible at this time. There is an enormous amount of wisdom in this book. There are many things in here that will help a person live a more healthful longer life. It is a very optimistic book about the future of our health care and the human condition. You can learn some biology. The author is very knowledgeable and at the top of his profession. Everyone should read this book. Helpful Report S. Mims 4.0 out of 5 stars One of the most important books that I’ve read in the past decade. Reviewed in the United States on October 28, 2019 Verified Purchase Lifespan: Why We Age – And Why We Don’t Have To This is one of the most important books that I’ve read in the past decade. I’ve been excited about scientific progress against aging for the past 40 years, and have been taking supplements of various kinds since I was in my 20’s. David Sinclair’s book details most of the real progress in the field, with the best examples coming rather recently – in the past few years. Sinclair exudes optimism, which matches my own natural tendency. As a narrative, the book succeeds in bringing the reader to an understanding of David’s initial motivation in his field, using the story of his grandmother Vera’s lifelong vitality giving way to decline and, ultimately, death. The reader also gets an historical retracing of the road to knowledge of telomeres, CRSPR, Sirtuins, and cell reprogramming. Did you know that there were sharks that have had life spans measured to have exceeded 500 years? Twice, while in bed reading the book late at night, I bolted upright when a new fact was revealed. The first wake-up was an anecdote in the book about one of Sinclair’s researchers coming to him for help on an issue with the young man’s mother. Seems she had started having menstrual periods again after starting to take a supplement (NMN, I think) that many on David’s research team were taking themselves. Another shock was hearing of the reprogramming of optic tissue cells, using 3 of the 4 activators known to enable an adult cell to become a pluripotent stem cell. The 3 activators were CRSPR’d into the DNA of the receiving tissue, along with an activation mechanism that depends on receiving a certain antibiotic. So, dosage modulated regeneration of Optic nerve tissue was achieved in rats. That fact opens up the possibility of not only slowing or stopping aging, but actually reversing it. The first half of this book covers the history and amazing scientific discoveries, but unfortunately the second half oozes with virtue signaling as it reveals David to be an altruistic collectivist with all manner of political prescriptions he thinks are needed to save humanity from itself – from gun control to climate activism. I suppose it is inevitable that the progressive bubble of an academic environment blinds its inhabitants by disallowing any political disagreement. However, it made me come to question Sinclair’s own scientific rigor. If he hasn’t read of the hiding of temperature data, and suspiciously always lower “adjustments” to past temperature records which is central to the global warming hoax, what alternative aging hypotheses might he be ignoring as well? I dug into this a bit, after remembering that GlaxoSmithKline spent nearly a billion dollars back in 2008 for one of David’s startups working on Sirtuins (Sirtris). Back then, I was hoping that we’d see new anti-aging pharmaceuticals within a decade. Glaxo shut down the unit in 2013. That sounds ominous, right? But, comments on Glaxo’s page say that core researchers were offered positions in other parts of the company, and that Glaxo still thought the Sirtuin drug candidates were valuable. In the book’s “Cast of Characters”, it is stated that Elizabeth Blackburn was “controversially dismissed” from Bush’s Council on Bioethics “allegedly for her advocacy of stem cell research and politics-free scientific inquiry.” What’s missing from this statement is that said advocacy was for “embryonic stem cell research”. Bush’s constituency believed that this meant using human lives (albeit very young lives) for research, and this constituency did not want their tax money to pay for what they considered an immoral act. Again, the book seems to be using the material to make political jabs. Perhaps Dr Sinclair doesn’t realize this, perhaps he does. Much is also made in the book’s second half about trying to guarantee that anti-aging therapies would be made available to all, regardless of cost. I would hope that the examples of pricing in the space, auto, and computer industries show how capitalist countries succeed in bringing costs down for everyone, without government mandates. Space Shuttles used to cost roughly $20,000/kg for orbital flights. SpaceX has brought that cost down to around $2,000/kg. It is still way too expensive for the average American tourist. However, cars were once only affordable to the wealthy. Henry Ford employed capital to force down prices, extending affordability to the middle class. Prices start out high, which enables start-ups to raise capital. Then as volume goes up, unit costs are driven lower by competition. That’s how we got to 256GB USB sticks for $32. I once paid $10,000 for 0.004% of that much space. Drug prices would be driven down faster if the FDA only mandated safety testing, instead of both safety and efficacy. If drugs are guaranteed by the FDA to be safe, then we consumers should be allowed to try anything we want. Companies that want more market share would pay for efficacy trials, the results of which could be used in advertising. Drug development costs/prices might drop by 90% in that kind of market. Sure would cut the wait time for anti-aging therapies. 127 people found this helpful Helpful Report lucinda 5.0 out of 5 stars This book changed our life! Reviewed in the United States on November 27, 2023 Verified Purchase Every senior should read this book, but have a dictionary available because it can get technical. When all doctors want to do is dispense pills and treat illness - it is refreshing to embrace health and wellness. A well documented book. Helpful Report The Hobbyist 5.0 out of 5 stars Brilliant book from a brilliant man! Reviewed in the United States on October 10, 2023 Verified Purchase David Sinclair is a very big deal in the world of longevity, and he brings unparalleled knowledge to the masses with this book. I have the CD set, and it actually has some updated information from the book. I wasn't sure about listening to this book on CD, But Dr. Sinclair does an absolutely exceptional job of orating some very important and also very technical research results. What a time to be alive! 4 people found this helpful Helpful Report Tom Hunter 5.0 out of 5 stars If you read one book this year--let it be this one. It will show you how to live a longer life! Reviewed in the United States on December 20, 2021 Verified Purchase Of the 34 books I have completed reading this year, this is the best. Pay close attention to the subtitle. Though as we age, it's natural for humans to focus more and more on extending their lives--this book, written by the world-leading authority on aging and what it will take to extend our lives, gives concrete actionable guidance on what you personally can do to increase your life: * It shows the already known value of fasting, in that the act of skipping meals causes the body to switch to a life-extending mode. That means you at the very least skip breakfast. Your goal is to go as long as possible every day without eating. * It shows how the commercially available supplement NMN, a precursor to NAD, can have direct and noticeable effects on one's health and lifespan. * It shows how lots of small effects, such as exposing yourself to extreme cold for brief periods of time also triggers your body's natural life-extending mechanisms. I am not attempting to reproduce a 310-page book. To fully understand, read this book or the many follow on talks given by the same author. Sinclair begins this book by describing the "information theory of aging". Until his theory, the generally accepted idea has been that aging comes when the "digital" information that is held on DNA using the 4 base pairs becomes corrupted through information loss. Sinclair posits that aging is not a result of the corruption of DNA (which the body can fix) but the corruption of the companion to DNA that controls gene expression, the epigenome--which is separate set of chemicals and proteins that GOVERN how the DNA map is used to build proteins. Sinclair shows that it's possible to correct these epigenomic errors. The mechanism for doing this is quite interesting. It has been used to cause a damaged mouse optic nerve to re-grow. Absolutely fascinating and plausible in terms of the science involved. So, I will give you what you came here to see. The author near the end gives his own personal regime for extending his life: * 1,000 MG NMN supplement every morning * 1,000 MG resveratrol every morning * Daily dose Vitamin D, Vitamin K, aspirin * Keep sugar, bread and pasta intake as low as possible. * Allow yourself to be hungry for part of every day. Delay your first meal of the day as late as possible. * Skip one meal a day or at least make it really small. (Try to go as long as possible between eating.) * Lift weights * Expose yourself briefly to extreme cold, because that also triggers your body's survival mechanisms. This was a great and interesting read that I tore through. In no cases did the author make logical fallacies. It was scientifically convincing and legitimate-seeming all through. If you read one book this year--let it be this one. It will show you how to live a longer life. 93 people found this helpful Helpful Report Andrea Pgh 5.0 out of 5 stars Excellent Read; Excellent Author Reviewed in the United States on January 20, 2020 Verified Purchase This book is a very comprehensive view of not only the current research in anti-aging, but a sincere consideration of the implications of prolonging average lifespan and health span. Dr. Sinclair makes the science understandable while also bringing personal passion to the issue of aging and long-term health - it really means something for him. The book discusses WHY we age at a biological level, what that means for the pathways in which to stop that biological process, and the current research of what health practices, lifestyles, and most importantly which molecules can prevent or slow the process. After all, our bodies do not simply say "Well, looks like we are 60, time to start shutting down." There must be something happening at a cellular and biological level in our bodies that causes us to be "60" and not "20", so what is it? And given that there must be a process, why should it be impossible to intervene in it? On this premise, Dr. Sinclair discusses how a loss of information and DNA degradation contributes to a loss of cellular function that precipitates aging. He then goes on to explain not just THAT diet and exercise are helpful in increasing health span, but WHY - a much more scientific approach than just saying "eat your grems, they're good for you." Beyond that, and most interestingly, he relates the latest research on naturally-occurring molecules that can reactivate cellular function, and the promise such molecules may have - which to-date have demonstrated little to no negative side-effects and have moved into human trials. Because Sinclair himself is leading much of the research in his Harvard lab, this is not just another health book from another health guru attempting to peddle "advice" for money. It is a true attempt to communicate actual findings from esteemed research laboratories, and an attempt to do so so that the public can understand the latest science themselves instead of waiting for a patented pill to be offered via a doctor's office years from now with only half-baked information. I also want to note that, per his numerous statements in public forums, interviews and the book itself, Dr. Sinclair does not promote or profit from the sale of any commercial product - such as NMN, Resveratrol or NR. Though his name is invoked on many websites to give clout to commercial products, he makes a point to never endorse or sign a deal with any such commercial producer, precisely so that his integrity and the validity of the research cannot be called into question. Any stake that he has in any related company is disclosed and the nature of the involvement discussed, but again, he purposely does not profit from or endorse any commercial product. Personally, I recommend coupling or preceding the book with podcasts on which he has been a guest so that you can get a light, layman's background in the science before delving into the depth of the text itself. While the text is reasonably easy to follow, the information is still weighty and may be benefit from hearing a more high-level version first. 12 people found this helpful Helpful Report Blackbird 4.0 out of 5 stars great and important book, but with deficiencies Reviewed in the United States on August 30, 2022 Verified Purchase This is a well written and deeply researched book written by an expert in the field, with the help of a professional writer, that focuses on research, gene therapies and supplements that are intended to extend human, and even non-human, lifespans. As such, it succeeds brilliantly as it presents a wealth of material in a concise introduction to the subject and provides an excellent review of what he and other aging researchers and geneticists have learned up to 2019. Where I think the book falls short is in more thoroughly linking the effects of diet on health and in making, even in an Appendix, specific dietary recommendations, both pro and con, and providing a more thorough basis for the reader to make informed decisions. Yes, there are many other books that do this, but they do not provide the related genetic and supplement information, so readers are required to look in multiple volumes to get a more complete view of linkages between diet, health, and longevity. The book also makes very few references to exercise although it encourages the reader to be active every day. I think that a second edition of this book could be more useful by providing the core information covered in this edition, and updates, plus specific recommendations on what to and not to eat (or specific recommendations on where to get that information) as well as what kinds of exercise are recommended for each age group (or where to get that information). The obesity epidemic so prevalent in Western countries and food insecurity issues prevalent worldwide are not mentioned, and probably ought to be. There is emphasis at the end of the book on global food waste and on consumerism, and how these affect the planet's ability to sustain increasing human populations, but these are not integrated into the overall thesis that great strides in extending human lifetimes are upon us and solutions are not offered. A very thought-provoking book and one which offers a very optimistic view of the future, but one that I think ought to be expanded to integrate diet and exercise into the theme of extending lifespan. 35 people found this helpful Helpful Report Paul H. 5.0 out of 5 stars Very Informative and Fun to Read Reviewed in the United States on September 22, 2023 Verified Purchase I really enjoyed this book. David A. Sinclair AO and Author Matthew D. LaPlante did a great job of delivering a ton of information to the reader (in this case, me!) and still managed to make it lighthearted and enjoyable to read. After reading this, I have a feeling my life is not only going to be longer, but a whole lot healthier too. 5 people found this helpful Helpful Report john doba 5.0 out of 5 stars Entering the age of miracles & sci-fi Reviewed in the United States on March 19, 2023 Verified Purchase One of the world's leading aging researchers shows here it's not inevitable that we suffer a miserable, debilitated and perhaps senile finish. He offers not just some great health ideas, but a truly radical (and genuinely hopeful) new worldview, a revolutionary paradigm-shift on what it means to be a human being--it's that good. A bold new information-theory approach to aging--now already in place in leading labs---perhaps may make possible incredible sci-fi outcomes: regenerating lost limbs; actually reversing aging, through cellular reprogramming and other methods; and maybe even immortality one day. To those who say this is playing God: we've been doing that a long time. Our kind's quasi-divine creativity----"made in the image of God," according to the Bible---has already created many miracles; we've put men on the moon, eliminated smallpox, and brought ourselves up from the caves, by human ingenuity. To deny our own further self-improvement, would be the truly unnatural thing. And he backs this view up with some unexpected and startling economic and hard-nosed money views that persuade me he's right: aging we should see as a disease, that not only can be treated and cured---but must be, if we are going to survive as a species on this increasingly crowded and politically dangerous planet. The view looks a bit socialistic to my conservative American brain, but there's no going back to the caves---or so we hope. A game-changer, but will it be in time? Our clock, individually and collectively, is ticking. 15 people found this helpful Helpful Report Bhargav Patel 5.0 out of 5 stars The future of anti-aging explained in this book, secrets to a long life Reviewed in the United States on September 25, 2020 Verified Purchase David Sinclair is a brilliant scientist and leader in anti-aging research at Harvard and around the world. This book is a must-read for anyone. And I mean anyone! He and his team of scientists have discovered the revolutionary anti-aging breakthroughs such as the sirtuin genes which slow the process of aging by stabilizing our epigenome and preventing the loss of information in our cells. What that means is simply we live longer when these sirtuins are active. How can we do that? Read on. Keep yourself healthy now because a plethora of innovations are coming down the road that will revolutionize and lengthen our lifespans and healthspans (how many healthy functional years we live). How can we maximize our health now according to Sinclair? My 3 key takeaways 1) eat low protein diets 2) take Resveratrol, Pterostilbene and Nicotinamide Riboside or Niacin 3) let your body be exposed to healthy stressors like the cold or exercise Resveratrol and pterostilbene both directly activate the sirtuins which repair the epigenome as well as induce a state that mimics fasting and all its associated benefits. You can increase their absorption by combining them with BioPerine/piperine black pepper extract since they are not very bioavailable on their own. And NO your red wine won't make you live much longer since the amount you need to get the benefits would probably destroy your liver. Sinclair says he takes resveratrol every day. NAD+ is a cofactor for the sirtuins and necessary for their function. NAD+ is made either through niacin, or a newly discovered supplement/molecule called nicotinamide riboside which can easily convert to NAD in the body. It is very expensive compared to regular niacin but may be worth it depending on your age. I think younger people should just take a niacin supplement (but not "no-flush niacin", that has no benefit and has not been shown to increase NAD levels). Older people can take NR or NMN. Currently, there is more evidence backing nicotinamide riboside than NMN or nicotinamide mononucleotide. There a lot of great information in this book and it is certainly worth a read. David gives examples of his father and how following these methods have changed his life and have him thriving and fit in his 80s or 90s and climbing mountains and going on hikes and more. He also explains many of the scientific studies and discoveries behind this information. I would definitely check this book out either in text or audiobook format 14 people found this helpful Helpful Report Previous page Next page A Science-Based Review of the World’s Best-Selling Book on Aging Charles Brenner Author information Copyright and License information PMC Disclaimer The publisher's final edited version of this article is available at Arch Gerontol Geriatr Go to: Dear Editor Herodatus, the father of ancient Greek history, recorded lore about a what has been termed a fountain of youth 2500 years ago. Innumerable adventurers searched for the legendary waters and countless hucksters sold the dream and/or known false promises to enrich themselves. While age reversal is an old grift, the latest version has reached new heights of feigned legitimacy and hype. Lifespan: Why We Age and Why We Don’t Have To, written by Harvard scientist David A. Sinclair with assistance of journalist Matthew D. LaPlante (Sinclair and LaPlante, 2019), proposes two counterfactual questions on the back cover: “what if aging is a disease—and that disease is treatable.” The second counterfactual attempts to neutralize the first in the sense that if there were a gene or a pill that could treat aging, one could be convinced that we don’t have to age. In such a world, people could choose to receive longevity medicine to reverse the disease called aging. There are similar rhetorical setups in Dr. Sinclair’s public presentations: what if you could keep your grandparents alive and healthy for another hundred years so that they could meet your great grandchildren? These dreamy counterfactuals transport people away from three basic facts about aging that are not addressed in the bestseller. First, all vertebrate animal species have a distribution of natural lifespans that are limited by their gene sets—human longevity appears top out at about 120 years (Gavrilova and Gavrilov, 2020). Second, animal gene sets evolved to allow individuals to acquire food, avoid predation, find mates and successfully reproduce. Long-lived species like humans also provide a substantial investment in caretaking of offspring until they can obtain food, avoid predation and reproduce for themselves. The advantages conferred to youth by parents mean that genetic selections for parental health are extant in caretaking species. Such genetic selections for post-reproductive health are not extant in non-caretaking species (Brenner, 2022a). Third, for animals that can mate multiple times, longevity is an emergent property of the ability to continue to do all the things required to reproduce and promote the success of offspring. Animal gene sets have been subject to genetic selections for guile, strength and famine-resistance but haven’t been directly selected for longevity because, as a rule, animals are able to successfully reproduce when they are relatively young (Rose, 1994). Think of it this way: if foxes can reproduce at 6 months, what genetic selections are present for them to live for six years? The ones that live for 6 years might reasonably produce 6 times as many offspring as those who perish in a year but those who die in a year would still contribute to the gene pool so long as they are successful at reproducing. Indeed, experiments done in flies that were selected for the ability to reproduce late in life suggest that hundreds or thousands of genes, not single dominantly acting genes, are modified to allow every organ system to function better over time in the resulting long-lived flies (Burke et al., 2010). However, animals in the wild are under little to no direct genetic selection for longevity beyond that to produce reproductive success. A more fanciful science of aging is presented in Lifespan. According to the book, Sinclair discovered genes called sirtuins that extend lifespan in organisms from yeasts to humans and he found sirtuin activators in red wine and elsewhere. Why do we age? Sinclair’s theory is poor information transmission that can be fixed by greater sirtuin function. Why we don’t have to age? He says that we can take sirtuin activators every morning and soon, we’ll take chemicals that will safely reprogram our genes to restore youthful vigor. Readers can also sign up to measure their age (there will be a subscription for that) and join the author’s community of age-hackers who will reverse aging together. With the book having been translated into dozens of languages, expanded into a podcast, social media outlets, a newsletter, and a tease of sequels, it is high time to examine the book’s claims. Is aging a disease? Age is clearly a risk factor for a wide variety of diseases but aging is not itself a disease. The most powerful mutations ever identified—from worms to rodents—that can extend lifespan inactivate genes controlling growth (Bartke, 2021). Worms and mice with disruptions in these genes are small, infertile, and very long lived, thereby establishing the connection between growth and development and the process of aging. Indeed, Sinclair has voiced support for the idea that aging begins shortly after the fertilization of eggs. Thus, to say that aging is a disease is to pathologize life itself. Is aging treatable? In the sense that the rate of aging can be modified by genes and the environment, yes. However, aging is easy to accelerate, i.e. by smoking, overweight, infectious diseases and other factors, and much harder to slow. Caloric restriction extends animal lifespan when compared to caged animals with constant access to food. However, it is more accurate to say that unrestricted access to food is a life-shortening condition that is unlike conditions in the wild to which animals are adapted (Sohal and Forster, 2014). To be sure, lifestyle changes that improve fitness improve people’s health trajectory such that a person can go from an aging-worse lifestyle to an aging-better lifestyle. Getting healthier isn’t age reversal though. Do sirtuins extend lifespan in yeast, invertebrates and vertebrates? Has Sinclair discovered sirtuin activators? Based on 25 years of work by academic and industrial investigators, the clear answer to both questions is no (Brenner, 2022b). Whereas Lifespan claims that sirtuins are dominantly acting longevity genes from yeast to humans (Sinclair and LaPlante, 2019), analysis of the work reveals that in yeast, sirtuin genes help 1 in 5 million cells live longer in one model of aging whereas they shorten lifespan for the entire culture (Brenner, 2022b). Early reports of sirtuins extending lifespan in invertebrates could not be independently replicated. In 2011, researchers from 7 institutions published together that sirtuin genes do not extend lifespan in worms or flies (Burnett et al., 2011). We learned in 2016 that, just as it does in yeast, the fly sirtuin gene antagonizes lifespan extension in conditions of dietary restriction (Slade and Staveley, 2016). While all the positive results made global headlines and are described in Lifespan, the negative results have not been amplified by mass media. Resveratrol is the molecule found in red wine that Sinclair claims as a sirtuin activator. There is a global consensus that resveratrol disturbs the assay used to measure sirtuin activity and generates a false signal (Brenner, 2022b). Sinclair’s theories were au courant for two decades. Indeed, sirtuins and resveratrol have been subjects of hundreds of stories in the mass media. A 2008 New York Times article reported that sirtuin activators would be developed as diabetes medications that, as a side effect, would extend lifespan (Wade, 2008). The global interest in sirtuins and sirtuin activators was such that companies—most notably GSK—spent many billions of dollars trying to get a positive result and could not because the so-called sirtuin activators don’t activate sirtuins and because sirtuins are not longevity genes. Lifespan therefore represents a pivot in which a person central to the failure of the largest longevity medicine program in pharmaceutical history turns to the general public to retell his story. In the retelling, sirtuins are longevity genes and sirtuin activators are real. The tech and cryptocurrency bubbles of 2020–2021 pushed a great deal of private funding into companies in the longevity space. From afar, it may seem like breakthroughs are on the horizon. For example, Lifespan tells us that one can rejuvenate mice by partial reprogramming with Yamanaka factors that are used to convert cells from a grown person into stem cells (Sinclair and LaPlante, 2019). Lifespan does not tell us that when these treatments are performed on cells in the laboratory, one gets tumors and teratomas (Friedmann-Morvinski and Verma, 2014) and that there is no published study in which even 20 mice have been examined carefully for safety after trying these types of techniques. Moreover, while the general public is now relatively aware of CRISPR technologies and may think that it will be simple to modify our genome to increase our lifespan, they do not understand that there are no known dominantly acting mammalian longevity genes (and in fact Sinclair’s book implies sirtuins are just such genes despite the fact that they don’t extend lifespan). As the premise of the book is that we don’t have to age, it is no surprise that the book includes Sinclair’s daily regimen, which includes 1 gram of type 2 diabetes drug metformin in addition to aspirin, resveratrol and three vitamins. While Sinclair tells people these are not recommendations for others, he advertises the page number on social media in response to being asked what to take for longevity. Indeed, there is clear evidence from social media that there are huge numbers of followers that believe that Sinclair is providing them with an inside track to extend healthy aging. The regimen is potentially damaging for individuals without type 2 diabetes as there is strong evidence that metformin use blunts the beneficial effects of physical activity (Konopka et al., 2019). As maintenance of high degrees of physical (Lee and Paffenbarger, 2000) and mental activity (Valenzuela and Sachdev, 2009) are clearly geroprotective and polypharmacy is associated with greater mortality when controlled for comorbidity and age (Chang et al., 2020), the most highly reproduced page from Sinclair’s book may be contributing to significant health risks. In the accompanying Lifespan podcast, Sinclair makes innumerable non-evidence based statements about benefits of time-restricted eating, statements about age-reversal as evidenced only by changing biomarkers (Fahy et al., 2019), and even potential immortality by repeatable drug treatments. The latter statements were particularly shocking because one of the drugs used to lower biomarkers of aging was growth hormone, which is clearly defined by genetics as a pro-aging molecule (Bartke, 2021). For decades, the “worried well” were typically middle-aged people with a high health preoccupation (Miller et al., 1988). Today, at least on social media, longevity followers appear to include a significant proportion of young adults, suggesting that anti-aging fad diets, drugs and practices are being adopted in ways that could add many years of exposure to drugs that lack an evidentiary basis for their off-label adoption. Sinclair’s attempts to commercialize scientific discoveries have an abysmal track record—these include the multibillion dollar investment of GSK in his sirtuin story (Schmidt, 2010) and Ovascience, whose work in female fertility could not be replicated (Powell, 2006; Weintraub, 2016). For scientific discoveries to be developed they need to be real but for books to sell, the stories just have to be good. The reach of Lifespan is a problem for the world precisely because a Harvard scientist is telling fictitious stories about aging that go nowhere other than continuing hype as legendary as anything in Herodotus. ​ Members of the general public and investment community have caught the longevity bug and appear to believe that major breakthroughs have been made in extending human lifespan Lifespan, a book by Harvard scientist David Sinclair, has become an influential source of misinformation on longevity, featuring counterfactual claims about longevity genes being conserved between yeast and humans, the existence of supposed activators of these genes, and claimed successful age reversal in mice based on partial reprogramming The book has popularized a stack of drugs and supplements with significant potential to harm the general public The reviewer suggests that scientists and physicians emphasize to the general public that aging is known to be a highly polygenic developmental process and that the most important things that people can do to age better are to maintain high physical and mental activity Go to: Funding: CB was supported by a grant from the NIH (R01-HL147545) and the Alfred E. 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[Google Scholar] Lifespan Summary July 13, 2022 Maria Deac Education, Health, Science, Self Improvement 1-Sentence-Summary: Lifespan addresses the concept of aging and defies the laws of nature that humankind knew till now by presenting a cure to aging that derives from exetensive research in biology, diet and nutrition, sports, and the science of combating diseases. Read in: 4 minutes Favorite quote from the author: Lifespan Summary The human life cycle is pretty simple: we are born, we grow up, we mature in age, we age, and then we die. It’s simple, predictable, and unchangeable – or that’s how it used to be till now. Lifespan by David A. Sinclair addresses a new perspective on life itself and presents a cure for humanity’s biggest fear: aging. While there’s no cure to death, molecular biology, nutrition, and medical advancements found a way to treat aging just as if it was a disease. And since aging is one of the main causes of death, we’re getting pretty close to solving the big maze. It all starts from our perspective on aging, and it moves up to everyday actions. To get a better understanding of how we can combat the aging process, let’s look at three of the most important lessons from this book: Aging is the result of a loss of information in the DNA, but the process can be helped. We can programme our genes to live longer and preserve our organs better. Telomeres shortening is one of the primary reasons of aging. To get a better understanding of these lessons, I’ll try my best to go over these scientific concepts in detail and get the main idea out of each and every one of them. Let’s start with the first one! If you want to save this summary for later, download the free PDF and read it whenever you want. Download PDF Lesson 1: Genes are fragile and can easily alter if we don’t take care of them Aging is a complex process that is a result of many internal and external factors. In big lines, it occurs as a loss of information in our DNA. Simply put, our genes forget how to replicate the healthy cells and lose the ability to reproduce good genes altogether. DNA alters when genes are replicated incorrectly, and this happens because our body forgets how to replicate them perfectly. The root of this negative occurrence lies within the very moment of our conception, when information is transmitted to the epigenome, who relates the message to our body. Our body receives a gene marking map, where all of our genes have a tag that defines whether they are brain, kidney, liver, or any other type of cells. Sadly, they sometimes forget that, and end up becoming unstructured cells. They don’t reproduce anymore, and when they do, they create even worse cells. To reverse this declining process, we’ll have to look at nutrition and the superfoods of the world, what the most longevive populations do to reach an old yet active age, and how to use plants to activate genes in a good way. Lesson 2: You can nourish you body and prevent aging with food, exercise, and sleep It’s no secret that a healthy life will keep your body in good shape for a long time. However, you’ll still end up all aged, wrinkled, and senile – you may think. Wel, according to this book’s extensive research, you can avoid that! How? Just look at the Blue Zones. The Blue Zones are essentially territories like Greece or Okinawa Island who are well-known for their nonagenarian people. So what do they have in common? A plant-based diet with low intake of animal protein, a fasting period, and a lifestyle that promotes “the desirable state of stress”. This state of being implies that our body must not keep consumption high, but rather seek the survival mode to have its cells stay awake and reproduce themselves. This happens through fasting, when your body gets enough to get by, but not too much to enter a latent mode. In terms of food that activate the genes and protect your body, the author highlights red onion, capers, kale, and a mushroom from Chile that it’s also used to combat the immunostate where your body rejects new transplants – rapamycin. On top of that, a good amount fo exercise, physical stress, and fresh air can add years to our life. Lesson 3: DNA can get damaged and produce zombie cells that speed up aging Aging happens for a number of reasons, and one of them has a lot to fo with zombie cells. These cells are essentially senescent, which means that they forgot how to replicate. What’s worse is that they’re not dead wither, which means that they linger around in our body and affect the healthy ones. In other words, they speed up the aging process. Cells become senescent due to the shortening of the telomers, or the protective caps of the DNA that occurs when cells divide. Sometimes our body interprets that in the wrong way, thinking that the DNA is damaged and needs urgent repair. During this process, ells are often repaired wrongfully, which leads to cancer. Another thing that can happen is that the system shuts down the process and these cells become senescent, or zombie. The trick is to get rid of them, and the current state of medicine fortunately allows for that to happen. Senolytics, or nutrients found in kale, red onion, or capers, are here to help! Another potential solution is to reprogram our cells from the little seed that stayed intact since day one. This is called the Yamanaca method and it’s quite a new technology. Medicine is yet to provide a definitive procedure for this process. Transcript of Lifespan Book Review Books With Brett 0:07 hey everybody how's it going welcome to 0:09 another video 0:10 um it's a really cold day so i'm 0:13 all zipped up in my big old thick jacket 0:17 so today i want to make a video about 0:18 this book 0:20 lifespan why we age and why we don't 0:23 have to 0:24 by david sinclair so 0:27 i mean the title of that book in and of 0:29 itself you know 0:30 when it says why we age and why we don't 0:32 have to that 0:34 obviously is gonna catch people's 0:35 attention i know what caught my 0:37 attention when i saw it in the bookstore 0:38 because 0:39 because obviously we all have to age we 0:42 can't just 0:43 you know go on being the same age 0:45 forever age seems to just be 0:47 a part of you know living a natural 0:51 life and ultimately um after reading 0:54 this book 0:54 i do feel that that's not the best title 0:57 for this book because ultimately 0:59 in this book the author is not offering 1:02 us 1:02 immortality or a solution that's going 1:04 to grant us 1:06 immortality this book is not about 1:09 how we are going to stop aging 1:12 or end aging to the point where we no 1:15 longer age 1:16 as individuals we're always going to age 1:19 what this book is offering is it's 1:21 offering some insight into how 1:23 potentially 1:24 with more time with more patients 1:27 and with more research um science may 1:30 eventually in the future be able to make 1:32 breakthroughs 1:34 that allows us to drastically slow the 1:37 aging process 1:38 um and in the process extend 1:42 the average human lifespan by decades 1:45 right now i think the average human 1:47 lifespan is still at like 1:49 80. um but 1:53 this author is claiming that if 1:56 scientific 1:57 research into aging continues which in 2:00 this book he actually talks about and 2:01 says that aging research and science is 2:05 you know really making advancements and 2:07 that 2:08 reputable scientists from all over the 2:10 world meet 2:11 i think like every month to talk about 2:13 the advancements that are happening in 2:15 aging research 2:15 where they can eventually like really 2:17 slow down the aging process 2:19 and if this stuff works the way that it 2:22 looks 2:23 like it might work um in the not too 2:26 distant future we might be able to 2:28 extend 2:28 the human lifespan from 80 2:32 to something like 100 or 115 2:36 or 130 which sounds crazy 2:39 um and initially the first reaction a 2:43 person might have is 2:44 you know no that sounds terrible like i 2:47 don't want to live to be a hundred or 2:48 130 because 2:50 obviously as we get really really old 2:52 our bodies become 2:53 you know less durable um you know we're 2:57 weaker 2:58 we need people to help us out and take 3:01 care of us you know life really isn't 3:03 the same after 3:04 a certain age so it's kind of like if 3:06 you 3:07 if if life isn't the same at 80 do you 3:09 really want to live another 3:11 20 to 50 more years doesn't that seem 3:13 like a little 3:14 overkill haven't you already lived your 3:16 best years but 3:18 david sinclair the author he argues and 3:20 says that you know such a concern one is 3:22 valid 3:23 because obviously you don't want to have 3:25 this very long lifespan 3:27 and have a really bad life in terms of 3:29 what you can do 3:30 and just the quality of life but the 3:32 author says that the same kind of 3:34 research that would look into 3:36 increasing the human lifespan because 3:38 the lifespan is 3:39 how long in terms of length how long 3:42 your 3:42 your life is that the same research 3:45 that's looking into 3:46 increasing the human lifespan is also 3:48 looking into increasing the human health 3:50 span 3:51 meaning that if the researchers can 3:53 actually extend the human lifespan to 3:55 like 100 or 130 3:57 something like that then they're also 3:59 going to be able 4:00 potentially they'll be able to also 4:02 extend 4:03 the human health span meaning you won't 4:06 feel 4:07 like you can't move at age 100 you'd 4:10 actually would feel 4:11 really good at age 80 you might feel 4:13 like you're 4:14 60 years old when you're 100 years old 4:17 um 4:18 you might feel you know really good 4:22 and it's kind of funny to think about 4:24 this and even like say it 4:25 but like if we can actually make these 4:27 advancements it would be possible 4:29 um where you would feel 4:32 good at like age 115 or something 4:35 you know you know you have to obviously 4:37 be skeptical because 4:39 you know is it really going to be the 4:43 case that we can 4:44 live to be that old i have no idea you 4:46 know i mean this is outside of my 4:49 domain of knowledge you know i don't 4:51 really know much 4:52 about biology and this is a biology 4:54 based book about how to 4:57 increase the human lifespan but 5:01 um you know 5:05 you know one of the things this book 5:06 talks about and something that i do 5:08 believe 5:08 is before you eventually accomplish 5:11 something 5:12 or like as a you know as humanity 5:14 eventually you know before we 5:17 before we tend to accomplish some great 5:19 thing like 5:21 landing on the moon or 5:24 inventing airplanes just the 5:27 technological advancements we're making 5:31 as humans you know if you had looked 5:33 back 5:34 years and years ago and talked about how 5:36 right now on this phone that i have i 5:38 can make phone calls i can record videos 5:41 and i can upload them to something like 5:42 youtube where everyone in the world can 5:44 see 5:44 i mean just 40 years ago that would have 5:46 been like mind-blowing you know but here 5:48 we are 5:48 and you guys are watching this video 5:50 with all of these advancements that have 5:51 been made by technology 5:53 so you know when it comes to the 5:55 advancements of science 5:56 thinking about extending the human 5:58 lifespan 6:00 to live over a hundred years old it 6:03 sounds crazy it sounds 6:06 insane it sounds like something that 6:09 might 6:09 be you know unfathomable but 6:12 with time and with research and with 6:16 more work and more innovation something 6:19 that sounds 6:20 crazy or far-fetched actually could 6:23 potentially 6:25 become a reality when you really think 6:26 about it so 6:28 is it a big idea yeah is it kind of 6:31 far-fetched yeah 6:32 but far-fetched things with enough time 6:36 and with enough work and with enough 6:37 innovation 6:38 end up becoming reality you know so 6:43 i'm optimistic because i mean if you 6:46 could tell me that i could live to be a 6:47 hundred years old 6:48 and you know not not be falling apart 6:53 you know by age 80 but like still have 6:55 good 6:56 healthy enjoyable years you know 7:00 before i die then that would be awesome 7:02 you know sure i'll take an extra 20 7:04 years from my life who wouldn't want to 7:05 do that you know 7:06 so this book is broken down into 7:08 different parts and the first part 7:10 um is about the science behind what he's 7:13 talking about 7:14 so like the research and like the 7:16 biology behind how we can advance the 7:18 human lifespan 7:19 i'm not really going to go into that in 7:21 this video if you're interested in that 7:23 you can pick up the book and you can 7:24 read it because i mean the biology is a 7:27 little complex and i don't really know 7:28 too much about that stuff even 7:30 after i read the book there's still 7:32 certain things i'm kind of like you know 7:34 i'm just trying to understand the best i 7:35 can but 7:38 essentially what i will say 7:42 is that you know he talks about certain 7:44 studies that have been done 7:45 on things like yeast which when you 7:48 think about yeast you're like 7:49 research on yeast and aging but the 7:51 thing about yeast is 7:52 it actually shares like 70 of our dna 7:56 and yeast can age very rapidly 7:59 like yeast can age within like the span 8:02 of a week 8:03 like really rapidly like east can age a 8:06 lot over a week whereas humans obviously 8:08 we age over a longer period of time but 8:10 yeast 8:11 makes good participant for 8:14 something like this because you can 8:16 actually look and see okay if this 8:18 can stop or at least slow down aging 8:21 then we can do it on yeast and within a 8:23 within a week we'll see 8:24 the effects and if it does actually help 8:27 reduce aging 8:28 so they've done research on yeast 8:30 they've done research on like 8:31 mice and rodents and monkeys and 8:35 different stuff and what they found is 8:38 they have these 8:40 they have this idea of what they call 8:41 longevity genes or 8:43 uh sirtuins and these are some 8:46 things that may be playing a role in 8:49 aging so essentially the idea is that 8:54 with the research they've done in these 8:56 different areas 8:58 there's some research that suggests that 9:00 if we learn how to 9:02 utilize certain kinds of 9:06 certain kinds of things in biology we 9:08 may be able to tweak 9:10 our dna or our bodies in a way where we 9:13 can actually 9:15 you know live much longer and slow down 9:17 the aging process like 9:19 by a lot in humans now 9:22 that all sounds good or at least most of 9:24 it sounds good maybe there are people 9:26 who don't want to live longer even if 9:28 they do have quality years and they're 9:30 not in pain and 9:32 not super super brittle right but 9:35 even for those who say that sounds good 9:37 there are still 9:38 very serious problems you have to think 9:42 about 9:43 when you think about us living that long 9:46 so the first problem that comes to mind 9:47 is careers because 9:51 if people plan on retiring at 65 9:54 if we're live to be 130 years old 65 is 9:57 like 9:58 only like halfway there you know you 10:00 just you're only like halfway through 10:02 life at that point so you can't retire 10:03 at 65 anymore 10:04 you're gonna have to work for decades 10:06 and decades and decades and decades more 10:08 you're going to have to continuously 10:10 reinvent yourself in your career 10:12 you're going to have to continuously you 10:14 know put forth and 10:17 um you know just more decades of work 10:20 and that doesn't always sound so 10:21 appealing to many people many people are 10:23 like i got to work for 50 more years 10:25 you know a lot of people don't even like 10:27 their job to begin with you tell them 10:28 they got 50 more years of it 10:30 they're not going to be too happy about 10:32 that right so 10:34 that's one thing just to think about in 10:36 terms of retirement 10:38 and career and social security and being 10:41 able to provide for people who have 10:42 retired but they're living and living 10:44 and living and living 10:45 so something like extending the human 10:48 lifespan not only would it obviously 10:50 change our lives in terms of the length 10:51 of our lives 10:53 but it would also change our lives in 10:55 terms of how we think about our career 10:57 how we think about taking care of people 10:59 who are retired 11:00 you know it kind of drastically changes 11:03 everything that we think about with just 11:05 that alone 11:07 then you have the problem of 11:09 overpopulation 11:10 because if we're living longer 11:14 and we're still reproducing and we're 11:16 still having kids 11:17 the problem is is now you're going to 11:19 have less and less room and less and 11:20 less resources 11:22 and in this day and age where climate 11:24 change is already a problem 11:26 where things like you know everybody is 11:29 extending 11:32 you know in a situation where a lot of 11:33 people are already consuming 11:35 more than they really should in order to 11:38 actually live an environmentally 11:40 healthy lifestyle um 11:44 you know having people con having more 11:46 people 11:47 consuming and consuming consuming over 11:49 time on the planet all at the same time 11:51 is going to have a lot of detrimental 11:54 effects on 11:55 the environment and on the planet even 11:57 more over consumption 11:59 than we initially have that's that's 12:01 another problem 12:03 so you know those are things that 12:06 even if we could extend the human 12:08 lifespan those are all problems that we 12:10 could still 12:11 run into and issues that we could still 12:14 have 12:15 and the author dr sinclair 12:18 um you know he 12:21 he thinks those are all valuable things 12:23 to consider he's not like you know 12:24 brushing that off as like oh that's who 12:26 cares we'll just extend the human 12:27 lifespan and there's no problems to 12:29 think about at all 12:31 but while he does believe that those are 12:32 issues that require a lot of attention 12:35 and thinking um he is optimistic 12:38 that humans will use innovations and 12:41 technology 12:43 and society to allow us to 12:46 adapt to those kinds of scientific 12:48 advancements 12:50 and he points out you know times in 12:53 history where you know for example 12:55 when people were saying that the earth 12:57 was already getting too overpopulated 12:59 like hundreds of years ago you know 13:01 inventions like the sewage system and 13:03 other inventions made it so that more 13:05 people 13:06 could still live on the planet without 13:08 exhausting its 13:09 natural resources so he you know his 13:12 answer is 13:13 he is optimistic that human innovation 13:17 you know not only will human innovation 13:18 allow us to live longer 13:20 but human innovation can also allow us 13:22 to 13:24 you know learn how we're going to live 13:25 on this planet with those advancements 13:28 so um hopefully he's right because 13:30 that's 13:31 that seems to be like a glaring issue if 13:34 we could extend the human lifespan 13:36 which i would like to extend the human 13:37 lifespan because yeah i would like to 13:39 live longer as long as the years are 13:40 quality years 13:42 but i don't think that you know i do 13:44 think that 13:46 the problems of overpopulation and like 13:48 i said before 13:49 career those are all things that you 13:52 have to take into consideration 13:54 but overall i really enjoyed reading 13:56 this book this book is really really 13:57 cool 13:58 i would definitely recommend this book 14:00 um to anyone who likes to read about 14:03 you know the future like what the future 14:05 could be like um anybody who likes to 14:08 learn more about 14:09 um you know innovation 14:12 in terms of how science you know 14:14 scientific innovation can change the 14:16 world and 14:17 where we might be headed i would 14:19 recommend you read this book 14:20 um should you believe everything you 14:23 read in this book 14:24 no i don't think so i think that you 14:26 need to have a little skepticism 14:28 um you know even the author has some 14:30 skepticism but he's 14:31 pretty confident and he runs a lab at 14:35 the harvard medical school 14:38 and this is just one lab in the world 14:39 that he says um 14:42 that right now they do research and they 14:44 do work every single day 14:46 um it's a lab filled with reputable 14:48 scientists who do work 14:49 looking into how we can extend the human 14:52 lifespan and he argues and he 14:54 says in his book that this is becoming 14:57 more and more accepted in the scientific 14:58 community 14:59 that with some time it's going to happen 15:04 that with some time it is going to be 15:06 the case 15:07 that we are going to live longer um and 15:10 he's pretty confident so 15:12 i mean could it happen i think it could 15:14 happen but 15:15 i'm you know 15:18 it might be the case that he's a little 15:20 overconfident and maybe he 15:23 isn't taking other factors into 15:25 consideration 15:26 so anyway i'm excited to see what 15:29 happens as time goes on this book has 15:31 actually 15:33 um you know i guess motivated me to like 15:35 kind of like look up 15:37 what's happening in the science of aging 15:40 as time goes by and just kind of keep my 15:41 eye on like okay like what new stuff are 15:43 they finding 15:44 what new studies are being done you know 15:46 because now 15:48 this book's left me like a little 15:50 curious as to how this is gonna 15:52 continue forward and where it's going to 15:53 take us so anyway 15:55 um i hope you guys enjoyed this video 15:57 give it a thumbs up if you liked it 15:59 subscribe to my channel if you haven't 16:02 um go ahead and let me know in the 16:04 comment section what you think about 16:05 this idea 16:06 do you think that eventually humans will 16:09 be able to live a lot longer 16:11 um do you want to live longer 16:14 or does the idea of you know living to 16:17 be 16:18 120 or 150 like 16:21 scare you or sound really bad or 16:24 something is it too much time to you 16:26 or are you excited are you are you 16:28 pumped to potentially 16:31 live to be like that old are you like 16:33 excited about it so let me know in the 16:34 comments section what you think 16:36 um if you know somebody who likes to 16:38 think about you know 16:40 extending the human lifespan or someone 16:42 who just loves science and 16:43 innovation in general let them know 16:45 about this video let them know about 16:46 this book 16:47 anyway i hope you guys enjoyed the video 16:49 and i'll see you guys next time bye Unlock LONGEVITY Secrets with Dr. David Sinclair's "Lifespan" | Levels Book Club Levels 90K subscribers Subscribe 767 Share Clip Save 27,392 views Jan 3, 2022 Levels advisor and author of Lifespan, David Sinclair, sat down with Levels Chief Medical Officer, Casey Means, Head of Growth, Ben Grynol and Head of Research & Development, Taylor Sittler during our Levels Book Club on December 16, 2021 to take questions from our team and our members. Sign Up to Get Your Ultimate Guide to Glucose: https://levels.link/youtube?utm_campa... 00:00 - Intro 02:19 - The concept of death 05:44 - Extending youth vs old age 07:47 - Health needs to start young 14:29 - Using Inside Tracker 33:40 - Chronological vs. biological age 52:19 - How Levels will help make longevity research more equitable 56:43 - Research is evolving quickly 01:05:54 - The role of biomarkers 01:11:17 - The impact of COVID 👋 WHO WE ARE: Levels helps you see how food affects your health. With real-time, personalized data gathered through biosensors like continuous glucose monitors (CGM), you learn which diet and lifestyle choices improve your metabolic health so you can live a longer, fuller, healthier life. 🔗 LINKS: Subscribe here on YouTube: https://youtube.com/levelshealth?sub_... Chapters View all Transcript Follow along using the transcript. Show transcript Levels 90K subscribers Videos About Become a Levels Member Become a Levels Member Ultimate Source for Metabolic Health Information Learn more on the Levels blog 74 Comments rongmaw lin Add a comment... @ximenadalel828 @ximenadalel828 1 year ago Thank you Dr Sinclair,you are so big, you are our blessed 🙏🏻👌🏻😍 1 Reply @madalinastoica @madalinastoica 1 year ago Could you please discuss your views on ASD and ADHD please? I am very interested to know what you think of it. I specifically want to help my almost 6 year old twin boys, one being non verbal. I would truly appreciate any feedback from your side. I believe you are doing revolutionary work and I thank you so much! We need more people like yourself 👍🤗 4 Reply @thesystemera @thesystemera 1 year ago Woot. Have jumped into this exciting new world. 😂🌍 3 Reply @kennylo8423 @kennylo8423 1 year ago Thank you guys ! For this! Do more ! 🥰 7 Reply @dongyanchenschannel @dongyanchenschannel 1 year ago thanks for the information! I wander how to join the book club with David Sinclair? 2 Reply @bradleypoe-laulu433 @bradleypoe-laulu433 1 year ago I love this 3 Reply @galespressos @galespressos 1 year ago Envy the fat loss and age reversal. That’s super! Reply @calleymeans @calleymeans 1 year ago Wow 2 Levels Reply @hotchicsf @hotchicsf 1 year ago Just a quick note: I took metformin while exercising (I have to take it every day because of diabetes), but I grew muscles anyway, from weight training. My goal wasn't to gain muscles, it was to strengthen my joints, which it did, but the muscles grew also. I know that's just one data point, and from an Asian female, which is not even a target subject, but I thought it might be interesting to someone. 2 Reply 3 replies @scruffyhenry8277 @scruffyhenry8277 1 year ago @ 1:17 his forgetfulness kicks in - oops! so much for his biomarkers! hahaha Reply 1 reply @JolicoeurAbear @JolicoeurAbear 1 year ago looking forward to watching this and hoping that some of them are from the meat eating, fasting, low carb keto crowd. 1 Reply @lizmallen3461 @lizmallen3461 1 year ago The last question…is it only synthetic melatonin only causing this calcification on the pineal gland or natural melatonin as well? Anyone know???? Reply @annetcell-ly4571 @annetcell-ly4571 1 year ago What about lectins in plant based foods? Reply @denisamuresan1418 @denisamuresan1418 1 year ago When will the product be available in Canada? I was SO excited when I heard David mention Levels on his first podcast episode but quite disappointed to see its only available for signup in the USA. Any timeline update? Is the company taking initiative to go to Canada or are you focused solely on USA right now? Very curious to know. Thanks for your time! Reply Levels · 2 replies @semaaral2498 @semaaral2498 1 year ago Steve Simpson, I check on him from YouTube. Thanks for mentioning on him one of Dr Sinclair’s podcasts 👏 But didn't come across Prof A. Simpson’s any of his podcasts yet but will check on his tweets if there is any. Australian Professor, The Author of the book "Eat Like The Animals" and mentioning highly from Dr Sinclair's #lifespan book on his front page🔬🐭 Probably advising protein-free eating style. I'm pretty convinced after recently has lost my mum because of dementia and Amino Acids coming from Meat & kind protein and if mTOR can't clean my old proteins because of these new arrivals🥴than will help my mTOR and leave eating may be fish kind of protein once a while even though like Dr Sinclair's daughter or my grandsons like age 5/6, turn into total vegetarian which I hate to be one. But Looking forward to hearing more protein cleaning relation mTOR on humans. Thanks a lot If it's our health that matters here then we will stop eating Protein-based Amino Acids as Our Valuable Dr Sinclair says and listen to his researchers 👏🔬🐭 Thanks 🕺⭐️💫🦄🌈 Reply @lizmallen3461 @lizmallen3461 1 year ago My husband and I both started taking NMM one gram a day. My husband felt like he was coming out of his skin so he stopped it. He felt better. Upon resuming it, he had the same side effect. Can anyone address this for me on Sinclair’s team? Reply 3 replies @kefirheals7383 @kefirheals7383 1 year ago Extending lifespan can have implications we haven't even thought of. The most obvious one to me is, that people have a goal to retire from years of work, and they put aside adequate savings towards that goal, so they can enjoy the remaining years. If lifespan increases, will people then work longer? Will they have enough savings to support that longer lifespan? I'm talking the middle-class, not the millionaires who obviously can afford any scenario that crosses their path. Well, it will be interesting to see where it all leads. 4 Reply 4 replies @ohgee8804 @ohgee8804 9 months ago May I pm or email with Dr Sinclair Reply @bwryuun @bwryuun 1 year ago In lubbock, some people think living forever is bad because you’d never get to die and live with Jesus in heaven (But they’re not in a hurry to die today!) Reply @mimilove6360 @mimilove6360 1 year ago How do I get in this book club?? Reply @semaaral2498 @semaaral2498 1 year ago Help please I didn't understand a word this lady asked but I’m stressed from her long questions and her voice tone😔😔😔 Will stop this interview here for now. Dr Sinclair has a huge patient. But like to listen to his answers as well😔her voice is in my ears😩 Thank Lord 🙏She has said someone else will ask you questions. Ladies are making life difficult with their different styles of ( strange) questions🤗 Thanks..pls. We like to go forward but with these questions, we can’t go forward. What is their worry no idea I think they like to begin this programme but will decide after these interviews? If you are a health fanatic you go for it without digesting the results etc. if Longevity is your lifestyle, I think. There is one Lady who asked the best question how these people will be fed if life extends while the food is an issue in the world related to the climate changes or other issues on the planet👏 Reply @rariri1 @rariri1 11 months ago As long as mankind wants to improve lifespan, you can do it to some level, but when God wants to take you out because of your lack of fear of God, nothing you do will help you. Your life is in the hands of God. If God did not take you out for your lack of fear of God, God will allow the devil to do it. Have you ever asked yourself why people commit suicide?? Your life is controlled by spiritual forces you cannot fight against. Science cannot help you to live long life when the wrath of God comes against you for your devil worship and lack of fear of God. Ungodliness is a death warrant. What is the point of trying to live long when you live in Darkness where there is no life for separating yourself from God and being controlled by Satan. Those who have been kicked out of the kingdom of God for lack of fear of God are a living dead. Your flesh is alive, but you are spiritually dead: a dead man walking. You can live a hundred years on this earth and never live a true life from God. Can any man fight against God and win??? You are just deceiving yourself. I am a man of God, and I know things about this world you know nothing about. Life comes from God not from Satan that most of you worship. How can you worship the devil and want to enjoy the life that God created?? Ask yourself that question. God will allow the devil to enslave you with pains and suffering, diseases and sickness and death until your last day on this earth to punish you with God's authority for your lack of fear of God. I am a man of God sent by God to warn all mankind about the coming End Time. Apostle R. Reply @bwryuun @bwryuun 1 year ago I want to life “forever” and healthier than I am now. I saw A YouTube video a year ago (I forgot name) that 400 yrs is the maximum life span just due to accidents that kill people. Reply @bydezine1 @bydezine1 1 year ago Ok Reply @galespressos @galespressos 1 year ago . Quercetin? Can it be any kind of Quercetin? Is synthetic okay? Reply @donotmissDutch @donotmissDutch 1 year ago Hello The Future in the Netherlands are many problems with the climate, heating, wrong water, bad food, overcrowded, no houses and bad air because of TATA STEAL. please do something about that also. 1 Reply @nancybeyers8469 @nancybeyers8469 1 year ago Can you rejuvenate kidneys my husband has stage 4 1 Reply 1 reply @matthewferguson7084 @matthewferguson7084 1 year ago They don't like saying its a disease because it could be offensive to old people..but the truth will set you free just makes you angry first Reply @harlankraft578 @harlankraft578 1 month ago Watching a opposite ideology. Trying to be open even though I won’t ever trust Pharmaceuticals!! Reply @jackmwa902 @jackmwa902 1 year ago How can I join this book club? 1 Reply Levels · 1 reply @SquatFull @SquatFull 5 months ago If he has the cure for aging, then why does he dye his hair? Is he hiding gray hairs which is a sign of aging? Reply @bendikkirkbakk1833 @bendikkirkbakk1833 1 year ago Look around. Life and death is all around You. Its the most natural thing ever. I get calm watching tomb Stones. Nice place in the sun 3 Reply @jamesanastasius2756 @jamesanastasius2756 1 year ago I would like to die after meeting an alien from other dimensions and hugging them….that is my wish….I hope I could live longer until I see or meet aliens or be with their colony Reply @scruffyhenry8277 @scruffyhenry8277 1 year ago has he had botox..anybody know Reply 2 replies @nancybeyers8469 @nancybeyers8469 1 year ago Can you rejuvenate kidneys Reply 2 replies @bostaurus1 @bostaurus1 1 year ago Lisa she/her. Because I thought Lisa is a man's name. Reply @riddlescom @riddlescom 1 year ago He died his hair and is using filters. Lol What a joke. He should be natural 2 Reply 8 replies @elenabenjamin9980 @elenabenjamin9980 1 year ago Dr Sinclair you are my “Hero”, but this kind of comments about Trump are not good . It was only bad for the weak liberals! Because it was my funny and healthy time. Sorry about bother with my opinion.I follow and believe in you! Reply @dinomiles7999 @dinomiles7999 3 days ago Smoke and mirrors. Sad . $$$$$ Reply Remarkable Science: Understanding lifespan and why aging might be reversible with Dr. David Sinclair WBUR CitySpace 4.58K subscribers Subscribe 601 Share Save 33,572 views Streamed live on Dec 14, 2022 Harvard research and biotech founder Dr. David Sinclair is one of the world’s foremost thinkers on human longevity. A professor in Harvard’s Genetics Department and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Sinclair has found the ability to restore vision in aging mice with treatments that regenerate neurons. Sinclair is determined not only to slow but even reverse aging. In his New York Times best-selling book, “Lifespan: Why We Age – and Why We Don't Have To.” Sinclair provocatively suggests that aging doesn’t have to be inevitable. In the second part of our miniseries on longevity, join On Point host Meghna Chakrabarti for a conversation with Sinclair focused on his research and the latest on living a long life. Subscribe to WBUR CitySpace's YouTube channel here: / @wburcityspace Click on the bell icon to get notifications when WBUR CitySpace goes live. Visit WBUR CitySpace's website: https://www.wbur.org/cityspace Sign up for the WBUR Events Newsletter: https://www.wbur.org/events/newsletter WBUR CITYSPACE ON SOCIAL Follow WBUR CitySpace: / wburcityspace Like WBUR CitySpace: / wburcityspace Follow WBUR CitySpace: / wburcityspace ABOUT THIS SERIES We’re living in a time of scientific discovery and achievement that is, well, remarkable. In this regular series, host Meghna Chakrabarti will take your questions in deep dive discussions with researchers, scientists and innovators offering audiences access to what’s behind incredible scientific advances in a region world renowned as a hub of science and technology. Chapters View all Transcript Follow along using the transcript. Show transcript WBUR CitySpace 4.58K subscribers Videos About 98 Comments rongmaw lin Add a comment... @MarkZiegler @MarkZiegler 10 months ago I would stick with PHD's for moderators. 28 Reply 1 reply @juliak2591 @juliak2591 10 months ago I wish the interviewer would have asked more questions about the actual science of anti-aging than debating the anti aging concept. 27 Reply 3 replies @kingo55 @kingo55 10 months ago David handled that interviewer expertly. She can choose to live a shorter life if she wants... not sure why she was so offended. 45 Reply 8 replies @corinaglavan4528 @corinaglavan4528 8 months ago Another amazing dialogue! Thank you. David, I hope you are right and that by following your advice from your research I’ll live longer, otherwise I haunt you! 😊 I was joking. The truth is that I feel that I am reversing my age in following for the last two years your theories. Whether I live to 150 or die at 70 it does not matter, instead it matters the quality of my life that I am living. I’m very grateful. 4 Reply @brett7077 @brett7077 10 months ago This interviews was meh - David is great 14 Reply @digitalsyanide1746 @digitalsyanide1746 10 months ago Someone explain to me how sinclair looks like a Vulcan from start trek which is great due to their advanced technology and skills and Aubrey de grey looks and talks and has a name like a damn wizard if this is the timeline cern switched us to I am perfectly happy about this timeline with what is available in tech and possibly immortality lol 11 Reply 2 replies @warriorpathstudios1126 @warriorpathstudios1126 8 months ago Bro... for 53, Sinclair looks amazing and excludes youthful energy. 1 Reply @BarsandNightclubsAU @BarsandNightclubsAU 10 months ago Probably best not to let this lady near a microphone for a while. My god. 7 Reply @sherryrogers426 @sherryrogers426 10 months ago While I appreciate the questions of the host, they could’ve been stated, and more polite, less devils advocate way. Dr. Sinclair came across as a completely gracious wonderful human being. A person you would like to be friends with. The host was in my opinion, not very professional. 7 Reply 1 reply @almost-infamous7833 @almost-infamous7833 10 months ago (edited) This moderator made this discussion very awkward to watch. 8 Reply 1 reply @RajuGogul @RajuGogul 10 months ago He has several points to his credits!!!! Mindfully reading or listening to his book “Lifespan: Why We Age – and Why We Don't Have To.” might give us deeper dive into his insights and for our practice. 9 Reply @milamaslen3594 @milamaslen3594 10 months ago The interviewer represents the point of view that many people have. She does ask a lot of questions many so-called normal people ask when talking about aging and reversing it. And there is a widespread sentiment many people have that we are supposed to die or that aging is part of life or that it is natural, making it somehow good. Nature for many is associated with healthy and wholesome and right. Mind you, viruses and cancer and flesh-eating disease are also very natural, but we don't put them on a pedestal. Evolution has no mind of its own. It is a mechanism for survival and we really are the vehicle for genes. What happens to us - thinking, conscious, sentient creates the evolution doesn't care. We've battled the evolution for thousands of years now. By fighting diseases, by creating dwellings - safe, comfortable environments protecting us from weather elements, by taking care of our old who cannot hunt and gather themselves. We do care about survival past the age of reproduction. Aging is one more frontier on the path we are already on. But many are so used to the idea of aging, in many cases propelled by the ideas of Christianity, which says that is just another stop along the journey, that it shocks them to even think that that's something we can change. We do have a mechanism blocking the thought about our own death because it is too horrible to really think about. And I know some people make some kind of peace with it. But, I personally, will never do. I do think that however radical the idea of fighting aging is, it is just one of those important ideas we have to rethink and reevaluate and re-adjust to. Fighting aging will have a great pushback in society which will ask the same kind of questions - for example - what about God and soul and the end amount of resources. If this type of treatment became a reality there would be ethics committees and fears much worse than we have now about GMO, fears of inequality and overpopulation. But we already went through cultural changes that made unthinkable normal. We can do things right now that we would be shunned and put in jail for just a half of a century ago. 6 Reply 1 reply @johndoyle4468 @johndoyle4468 10 months ago As always David Sinclair is awe inspiring. However the interviewer is totally crap. Surely someone could have found someone better to interview David. She had a lot of nonsensical questions. 15 Reply 2 replies @gunjangupta6690 @gunjangupta6690 10 months ago I agree. It was good that she was asking lot of "obvious questions" that may seem unfair to Sinclair's fan but are out there. It really helped clear up the air on lot of Elon-Musk-Style anti-David-Sinclair propaganda out there... 7 Reply 1 reply @hulamei3117 @hulamei3117 10 months ago Peter Pan... major shade. 3 Reply @robynhope219 @robynhope219 2 months ago I'm beginning to think this whole thing about slowing or reversing bio aging is bullshit. I bought the book and was enthused about it, but now skeptical. For instance, I took Metformin for a year and felt no different. In addition I took some of the neutraceuticals he recommends...no change in my chronic fatigue. A strict diet hasn't helped, either. Maybe I'm too old to expect a change. I'm on DHEA now and hope for more energy down the road. Alas, I had to quit metformin bc of bad side effects. And as far as NMN and NAD, they're way too expensive for the average person. Overall, this business of anti aging medicine is for the rich😢 Reply @voiceanddrum @voiceanddrum 8 months ago The pursuit of “anti-aging” is about kicking the can down the road as much as possible. Imagine maintaining the youthful health of your twenties well into your 40s. And imagine reproducing in your 40s and 50s rather than from your late teens to your thirties. Wouldn’t you be a much better parent? The gap in her understanding is that the additional years are on the front end…pre-disease. Moving a disease state to much later in the human experience and allowing our end to happen quickly instead of over the course of years. It’s painful to think that humanity might improve their plight in such a significant way, but not in time for her own parents. Nor for mine. Rather than the terrible bandaids applied at the end of life, the idea is to create a youthful level of health for much longer on the front end. Reply 1 reply @ivascunicolae8920 @ivascunicolae8920 6 months ago Congratulations to Lifespan! Reply @alessandrobalboa3536 @alessandrobalboa3536 9 months ago amazing talks. the interviewer is amazing, all great questions Reply @gsferreira3048 @gsferreira3048 4 months ago Dr David por favor ja tem tradução de lifespam em portugues? Reply @slimbuttermilk @slimbuttermilk 3 weeks ago I’m a living example of proof that aging can be reversed! That’s why I’m going through my second childhood😊 Reply @rebeccah1437 @rebeccah1437 1 month ago Speak for yourself lady, I didn’t care for her attitude towards David. My husband died at 34 from cancer and I was his caretaker for years, I won’t be able to go though that again with the rest of my family members. His main point is to not die in a long and dragged out painful way where the person suffers in a living hell… she came off to me as passive aggressive towards him and he’s truly trying to help humanity. I like David, he seems really compassionate towards his loved ones that have suffered. I personally don’t believe we were meant to age this rapidly, life goes by too fast and humans used to live a lot longer Reply @rtnjo6936 @rtnjo6936 10 months ago Nah, she's actually good. I first wrote angry comment, but it's better to ask hard questions. THank you! 2 Reply @lisanidog8178 @lisanidog8178 10 months ago (edited) So what you look younger than you are. So am I! So were all the ones on both sides of the family. I just have “good genes” as dad used to say. I started graying at 35. Not completely white at 63. Not a wrinkle, and I don’t do a thing. My joints feel like 90. I take aspirin and creak along the best I can. I’m not age obsessed like this society. No wonder no one enjoys life. You can’t beat the clock. We’re all gonna go eventually. It’s called life. Reply 5 replies @martaschaffner6709 @martaschaffner6709 8 months ago En español, please Reply @secretname2670 @secretname2670 8 months ago David; "well we could heal aging as bodily decline instead of sticking a band aid on problems caused by aging" Interviewer; "then what would people die from? Someone should die" Well in my humble uneducated peasant's opinion , you shouldnt say out loud that other people should die, even if you want them to. She's also unprofessional constantly stopping sinclair mid-track and whatnot. Reply @elvisburgerking8675 @elvisburgerking8675 7 months ago (edited) 46:25 my partner who'd have guessed ? longevity is irrelevant without reproduction of the species LOL 1 Reply 1 reply @DeadGirlDeadSpace @DeadGirlDeadSpace 6 months ago The video audio is off… not mono… Reply @kelliesiwicki7398 @kelliesiwicki7398 9 months ago I can't take the echoing mic Reply @dorisford7313 @dorisford7313 5 months ago Echo Reply @dover1129 @dover1129 7 months ago i dont see any point in dying, so i hope we can get around that like integrating with AI or something Reply @yibichen @yibichen 1 month ago Aging research is for over come death obstacle , it's painful when you grow old and got disease ,the most is death itself. Many old peoples were suffering this and these are not right for us to thinking about it is a right things got disease and death. I am gotting to call you if you already successfully in human. No matter what I am gotting to finish this research work. Reply @zack_120 @zack_120 10 months ago Well, whatever and however much you eat less, you must have been eating enough energy and protein to allow you to get those biceps unless you've got ultra-thrifty genes. For people to believe what you said here you must explain this apparent discrepancy first. 1 Reply @robynhope219 @robynhope219 2 months ago (edited) Notice his choice of words "why aging MIGHT be reversible, NOT that it IS. Reply @marionharris5952 @marionharris5952 10 months ago Interviewer could have been better. 1 Reply @felipenajera787 @felipenajera787 9 months ago What she wants.. it’s an ok I’ll make you young for free, because you need it . Reply @lq4657 @lq4657 8 months ago She sounds confused lol 1 Reply @TaniaSeabock @TaniaSeabock 9 months ago I did not like this interviewer at all and thought it was just me. But after reading all the comments, it looks like I was not the only one. She made me cringe. 1 Reply @lisanidog8178 @lisanidog8178 10 months ago (edited) I don’t care how old Mr. Sinclair is. It doesn’t matter. 3 Reply 1 reply @rg-cb2wd @rg-cb2wd 10 months ago and now you can buy his subs for 5% less use the code scammer Reply @andreamazzaferro5168 @andreamazzaferro5168 10 months ago a waste of David’s time … and ours 7 Reply @reneoyanadel3377 @reneoyanadel3377 9 months ago The host the only bad thing in this video 1 Reply @margaritaa5780 @margaritaa5780 10 months ago David looks like his grandmama Reply @frankwilliams3036 @frankwilliams3036 2 weeks ago Why shouldn't we live forever? Reply @monag.769 @monag.769 10 months ago The moderator doesn‘t seem to accept nor understand what Dr. Sinclair explains. She is also very negative…what a waste of time and energy. 2 Reply @thomasjust2663 @thomasjust2663 10 months ago This woman was very annoying 5 Reply @thebeautiestbeast @thebeautiestbeast 10 months ago (edited) What is wrong with this woman ... She obviously never witnessed someone die in pain .... Dying is a real disaster ... 3 Reply 2 replies @dv8760 @dv8760 10 months ago Loved the interviewer 1 Reply @jerardogonzalez007 @jerardogonzalez007 10 months ago She meant half a millennium not plural millenia. She was annoying. 1 Reply @roberthadley4157 @roberthadley4157 10 months ago Worst moderator ever! 1 Reply @bororobo7036 @bororobo7036 8 months ago Dr is a dreamer with heavy vested interest between science/marketing and she is sort of intelligent, but boring to death. Reply @lq4657 @lq4657 8 months ago She's trying too hard to sound smart 1 Reply @haydukethor @haydukethor 9 months ago turned it off after hearing the host for a minute so annoying I’m out 1 Reply