Minimum fasting length required for autophagy | Guido Kroemer

Minimum fasting length required for autophagy | Guido Kroemer FoundMyFitness Clips 87.1K subscribers Subscribe 16K Share Download Clip Save 1.5M views 4 years ago #autophagy #aging #cancer A key regulator of the process of autophagy is: a drop in cellular levels of acetyl CoA, an end product of nutrient metabolism. As one would expect, fasting – the abstention from all nutrients – is a potent inducer of autophagy. This is especially true in mice, which begin to experience autophagy within a few days of fasting. However, critical metabolic differences between mice and humans make it difficult to extrapolate these findings to humans. In this clip, Dr. Guido Kroemer describes: the current state of knowledge about the minimum amount of time required for fasting-ind … 1,900 Comments Add a comment... Pinned by FoundMyFitness Clips @FoundMyFitnessClips 4 years ago (edited) Watch the full episode: https://www.youtube.com/watch?v=Gm626MgpveI&t=6s FoundMyFitness episode page: https://www.foundmyfitness.com/episodes/guido-kroemer More clips from this guest: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gJJa4R_-vlojMyq0GJK6xkn 62 Reply 3 replies @ksveness 8 months ago Unfortunately I came down with stage 4 metastatic prostate cancer acouple of years ago that has spread throughout my bones. Hormonecdeprevation therapy and radiation only hurt me so I refused continued treatments. I'm Canadian so the doctors now suggest suicide. F' that! I did a 21 day water fast in January and feel the best I've felt in two years. I'm following an intermittent fasting schedule and do a 4 day fast each month. I've beat their odds and I'm still alive! 1.2K Reply 114 replies @TerriblePerfection 4 years ago Please keep in mind that fasting isn't just about weight loss. I did a 3-day fast that cleared up months of atopic dermatitis on my face. Nothing helped before that. I encourage you to try it, but keep it to yourself. Friends and family are skeptical, and worry needlessly. 4.7K Reply 262 replies @kgfes @kgfes 2 years ago Family members who love you are the biggest drawback when fasting. They will discourage you out of fear of you suffering 406 Reply 20 replies @danphili3303 @danphili3303 3 years ago Been eating OMAD for two months now. Am in ketosis constantly. Only drink salted water during fasting. All my health problems have gone. No more pain. Dropped 18 kilos so far and had my first training session at the gym today. Feeling like a new man. I am 51. Oh yeh I also quit smokes and alcohol was a heavy user of both. 2.4K Reply 130 replies @softcolly8753 @softcolly8753 6 months ago The fact that his first response was "we don't know" makes me think this guy is worth listening to, he shows some honesty. 181 Reply 4 replies @edwardcoyle5425 @edwardcoyle5425 4 years ago Best answer ever, "We dont know". 420 Reply 18 replies @askseeknock7 @askseeknock7 2 years ago Respect on the learned who say ‘I don’t know’ 140 Reply 4 replies @dlg5485 @dlg5485 8 months ago I do 16:8 IF for 3 years now and I not only lost 65 pounds, but it fixed ALL of my health problems (hypertension, cholesterol, etc). I also do strength training for 60-90 min 3x per week. At 53, I am now in the best overall health and fitness of my entire life. My next step is to extend my daily fast to 18 hours and eventually incorporate a 48-72 hour fast once per month, for additional longevity benefits. I wish I'd learned sooner that fasting really is the key. 187 Reply 2 replies @jelenaninic3787 @jelenaninic3787 8 months ago I fasted 11 days. Best thing for body, soul and spirit ever!!! 24 Reply @ricardomendoza4464 @ricardomendoza4464 2 years ago When you fast really keep it to yourself, because then people try shoving food down your throat coming up with myths about “you’re going to get sick” or “god made 3 meals you shouldn’t be ungrateful for having that privilege” blah blah blah. 50 Reply 1 reply @threeone6012 @threeone6012 2 years ago I fast for 84 hours (3.5 days) once per month. The first day is easy, after that each day gets progressively less fun. Fasting and the CDED diet keeps my Crohn's in complete remission without any medicine. I've been doing it for over a year. 676 Reply 36 replies @Lorianne-1111 @Lorianne-1111 2 years ago Finished a 72 hour fast Wednesday. (Second one I’ve ever done). I always feel worse on the first day, which I think is more to do with cravings as opposed to actual hunger. Days 2 I woke up full of energy, went crazy clearing out the kitchen cupboards and went to bed that night with my body singing. Day 3 I was much more tired, and fantasising about my first meal later in the day, but it was manageable as I wasn’t having hunger pains. I didn’t weigh before or after, I did it purely to eradicate the inflammation issues that had cropped back up since the first fast at the beginning of 2019. It worked, as I knew it would. My glands went down, knee, ankle, lower back pain all gone. I had also been suffering with acne on my neck, which all disappeared. 857 Reply 47 replies @marleneg7794 @marleneg7794 3 years ago You had me at we don't know. 77 Reply 3 replies @supersonicdiesel4836 @supersonicdiesel4836 1 year ago Autophagy is only one of the benefits of a prolonged fast. Fasting, whether prolonged or intermittent, has tremendous benefits for metabolic health in general and for reversing Type 2 Diabetes. It is truly a miraculous thing 359 Reply 20 replies @charlesmartel342 @charlesmartel342 1 year ago This lady is scary smart. I can attest though to fasting and autophagy. Years ago I suffered a severe wound on my forehead from falling off of a house. When everything was healed and I was well, I still had a growth of scar tissue or some hard fibrous material just above my right eye and just under the skin. It was larger than a dime but smaller than a nickel. It was there for about 5 years. Then I started fasting. usually intermittent 16/8.But a 48 hour fast once a week. My growth thing just simply wasted away. There is a tiny remnant left, that is about the size of a pinhead, that I expect to completely disappear as I began fasting again. 16 Reply @tombaranowski6413 @tombaranowski6413 3 years ago Done 3 day and 2 day. It gets easier. Key, stay busy. Hoping for internal benefits. My age 70. 133 Reply 1 reply @davidmciver9483 @davidmciver9483 1 year ago At 76 I wanted to lose the final 5 lbs. to reach my goal of 175 lbs. Nothing was working. I went on a keto regimen and now have stabilized my weight at 165! I am never hungry. Have an eating window daily of 6-8 hours and a 24 hour fast is no problem. I feel great, play pickleball 3-4 hours 5 days a week. The physical energy and mental acuity I am experiencing has caused me to get annoyed at my peers physical and mental slowness. I thank God and ask for His help dealing with this newfound personality defect. 300 Reply 8 replies @imstilltyping @imstilltyping 2 years ago No wonder micky mouse always in a good shape! 18 Reply @adespade119 @adespade119 3 years ago Couldn't I just have a shot which puts me to sleep for 4 days. 23 Reply 3 replies @southpole9450 @southpole9450 1 year ago I had fasted once straight for 14 days. One thing I have noticed is that after 3 days you don't feel the hunger pain. 141 Reply 15 replies @subwaymirdif @subwaymirdif 9 months ago Started at age 60 fasting Mondays and Thursdays. Dry fast for 16 hours each. Had stents placed in my heart and was on a heavy medication. Given up all medicine and it's my tenth year without any problems. Moderate exercise and heart healthy diet is also part of my life. 124 Reply 11 replies @AZ-le8wl @AZ-le8wl 1 year ago Asking the question has taken 2 minutes of my life. The answer took 1 sec😂😂😂😂 5 Reply @JAnx01 @JAnx01 2 years ago (edited) Rodents have to almost starve themselves to death to induce autophagy. Humans: "Can we get the same benefits by not eating for 14 hours?" 31 Reply 6 replies @keerthidelwatta2785 @keerthidelwatta2785 1 year ago I have been fasting for 18 hrs daily and have my lunch after 12 noon and dinner before 6pm in the evening. I was able to achieve my ideal body weight by doing strength training once in three days. I feel very relaxed and healthy. 300 Reply 16 replies @christyhoffmann6056 @christyhoffmann6056 8 months ago I did IF 18/6 for three months & it healed the terrible psoriasis on my scalp in three months, amazing. I am now doing IF with Keto to get off BP meds & build muscle. I feel fantastic at age 65. I look 40, no face wrinkles or saggy arm or belly skin from weight loss. Thanks autophagy! 83 Reply @syn16 @syn16 9 months ago Love seeing these comments on peoples stories. I too have a very positive reaction to longer fasts. More energy, skin clears up, chronic inflammation goes away, etc. 21 Reply @champtech8755 @champtech8755 1 year ago According to Yoshinori Ohsumi (the 2016 Nobel Prize) it’s 24 hour fast triggers autophagy 33 Reply @mrrolandlawrence @mrrolandlawrence 1 year ago i totally agree with the sentiment about if you are fasting to keep it from people close as they will pressure you to stop. i did a 21 day fast. im no one special, just an average guy. up to day 5 was hard but after that was super easy going. after i had loads of energy, my eyesight had improved. i had also successfully killed the carb crash rollercoaster of emotions that many get throughout the day. the world record for longest fast though is a scottish guy in the 1950s who fasted for 380+ days. 169 Reply 28 replies @lilareed2320 @lilareed2320 3 months ago I did a 5 day fast mimicking diet and on day 4 The eyesight was noticeably better! I was shocked! 4 Reply @albondsgalaxy @albondsgalaxy 3 years ago at 43, i have been doing IF with my 5 hour eating window from 3pm to 8pm. outside of this im only drinking water with lemon, salt and ACV. so far my belly is flattening out slighty. about an hour after eating my last possible meal ill fall asleep no problem. ill wake up real early almost too early but with that im totally awake feeling. its totally worth the try if your tired of feeling and looking like crap as i was. plus its the cheapest diet on the planet (please dont fact check). Think about it, you really dont have to eat so much AND eat all the time. you save money, food tastes better, you start getting attention i think there is some truth the idea that IF makes you smarter (dont judge, this is such a rough draft). peace! 184 Reply 15 replies @ydakda7233 @ydakda7233 9 months ago In Aug 2021, I decided to fast for 7 days. When just 1 hour was left to complete 4th day my brain went nuts and I ended up having veg. augratin and apple pie 🤣 4 Reply @musicboy2003 @musicboy2003 1 year ago I am 68, began 16/8 sprinkled with 20/4 and OMAD at age 62. Have completed 8 5-day fasts during the past 6 years. Many benefits perceived by doing this, including better overall health, weight loss and body transformation, I.e., prolonged fasting can lessen or even remove old fat in places ordinary diet and even exercise cannot reach. Rhonda has been an absolutely fantastic resource throughout my journey. One thing I think we need to consider when comparing mouse to human models is the much shorter lifespan of mice. I’m sure it’s not a simple straight line comparison but it’s vital to understand and I appreciate the questions Rhonda poses to Guido along this line. 167 Reply @ube4856 @ube4856 1 year ago High intensity Health did a video on how regular exercise helps you get into autophagy easier. When your sedentary and eat poorly your body is less efficent at switching into autophagy. 19 Reply @PInk77W1 @PInk77W1 2 years ago I eat breakfast at 1 pm I eat dinner before 6pm I fast 19hrs a day 15 Reply 1 reply @TheHoth1 @TheHoth1 8 months ago I combined apple cider vinegar with my 16-8 fasting. Just a table spoon mixed with a glass of water. It seems to work. I lost 30 lbs in three months. I weighted 190 before that. My pre-hypertension is gone too! 19 Reply 2 replies @JokerScribe @JokerScribe 1 year ago Don't forget that fat loss is also a form of Autophagy...self eating so to speak. If you are overweight and losing weight from fasting...then some autophagy has a occurred. If no weight loss has occurred, then no autophagy has happened, but it has to done over at least a week period as weight can easily go up and down depending on water and food in the body. 18 Reply 1 reply @solaacefrooty6437 @solaacefrooty6437 3 years ago Fasting for 14hrs overnight is pretty effortless 53 Reply 8 replies @think_again82 @think_again82 1 year ago Yah I also did this fasting thing and it made me sleep better, i feel lighter, I move quicker than before I just do the 18:6 sometimes 20:4 fasting ratio, I feel hungry but the pains in my body gradually disappeares. 42 Reply @soundsidecolour @soundsidecolour 1 year ago I am a male, 6 foot tall and do OMAD, OR 23/1. Its great. If you stick at it your love handles melt away lol. 5 Reply @redcenterau @redcenterau 3 years ago (edited) Currently, I am on Day-One of a planned 5-day water fast. Will find out tomorrow if I am a rodent. If I don't update this comment in a couple of days, you would all know that I was indeed a rodent. 🐀 Back soon. 😛 Weight on Day 0: 78KGs. Day 1: Intense cravings between 22 and 24 hours after last meal. Managed to continue fast. Drank enough water to stay hydrated. Day 2: Woke up in cold sweat, feeling weak, felt ok after a few minutes of breathing exercises. Feeling energised later during the day. 👍😁 Day 3: Woke up full of energy, feeling great today with very little cravings for anything. Exercised as usual and still energetic throughout the day. 👍 Day 4: Very little hunger pangs. Light exercise. No fatigue. Feeling good. 💪One more day to go! Day 5: Had some trouble with acid reflux. Bit of searching on the net revealed that even if a person watches videos on food and eating, gastric juices are released in the stomach. So, while lying down, I experienced some unpleasant sensation with acidity. All good otherwise. Feeling great. 👍💪😁 Weight at finish of fast: 75Kgs. 146 Reply 41 replies @lahendrique @lahendrique 8 months ago For those who only looking for weight loss, it's actually just an extra benefit! The real or main benefits are improvements in your overall body condition. 5 Reply @samanthaporter6662 @samanthaporter6662 1 year ago I love fasting on a regular basis, if I am not fasting, I don't feel good! 6 Reply 1 reply @Jimbob-zn6bl @Jimbob-zn6bl 1 year ago Fasting 72 hours every month. Intermediate fast every day 18 hours!! 🙏💪😊 5 Reply @jovenvillanueva2852 @jovenvillanueva2852 6 months ago (edited) Couple of months back i had started to cut carb to minimum + eliminate sugar on my diet, I initially doing 3 light meal a day and after 1 month 2 meal a day, i had also started to do exercise during that time while making sure my calorie intake is less than what i burn. I am now ready to do omad starting next week. My goal is to fast for at least 3 days once i got comfortable with omad. Btw i lose 12 kg since, and my back pain, knots and constant migraine 24/7 is now just memory, i had multiple doctors and medication for that. i also think i am sharper now specially during reasoning and my stress level had gone down significantly. People around me is seeing the effect but they dont believe me when i say that all they need to do is just not eat at all. 😅 but some of them are now cutting carb a bit, while some are joining me during exercise, Well i am.happy with my accomplishments so far and determined to reach my goal to fast for days soon! 5 Reply @LTPottenger @LTPottenger 3 years ago Every second fasted is more autophagy and you always have autophagy going on. It will take 3-4 days to get into maximum autophagy however, which is much more dramatic than what most people experience day to day. 49 Reply 6 replies @0vermars520 @0vermars520 3 years ago Wow Hans Gruber survived the fall? Interesting. 21 Reply 3 replies @lorenzovillegas2457 @lorenzovillegas2457 1 year ago there are probably varying factors that influence the onset of autophagy 5 Reply @andrewd5135 @andrewd5135 3 years ago At least they can admit that they don't know. 4 Reply @biohackshq4072 @biohackshq4072 9 months ago He was very honest about not knowing the minimum about of time for autophagy to begin. But fasting has great benefits with or without autophagy. 3 Reply @ronn68 @ronn68 9 months ago Spreading eating over 10 hrs doesn’t really seem like intermittent fasting to me that could literally be breakfast at 7 am, lunch at noon, and dinner at 5 2 Reply @jerrydesu @jerrydesu 4 years ago Wow! Big difference between mice and humans. Going to have to do some prolonged fasts, not just intermittent or OMAD. :P 37 FoundMyFitness Clips Reply 6 replies @i__________i @i__________i 2 years ago Besides weight loss the benefit of fasting that I noticed is my skin become softer... Even im a male 24 Reply 2 replies @mikereiss4216 @mikereiss4216 1 year ago (edited) I've been doing intermittent fasting for at least six months(probably longer) where I typically don't eat for 16 hours or more (but not usually more than 20) and have noticed a lot of improvement with some of my issues. I don't know if 16 is the magic number but I will say fasting can help heal your body. The weird thing is longer dry fasting ( I did a few 1 and 2 days of it and 2 four days of it) didn't seem to do much for me. Everyone is different though and needs to experiment and find out what works best for them.For me, long termintermittent fasting has worked the best for me so far. 37 Reply 2 replies @92OnTV @92OnTV 8 months ago (edited) I've been doing 20/4 intermediate fasting since September 2022. Couple times was 24 hour fasting, like OMAD, now at the end of March 2023, went from 89kg 109cm weist to 69kg 81cm weist. It could be better, but I have some loose skin at lower abdominal part. But I've notised some improvment in last 7-10 days. If not loose skin, I could say, that I'm completely happy with the result, but even now I'm preetty much got what I wanted. Would try 2 day fasting in some time this spring. 7 Reply @brucewayne5221 @brucewayne5221 4 years ago I think it depends on many things besides just the time in the fasting state. You have to take in to consideration lots of variables such as activity levels (exercise or stagnant), what was consumed prior to beginning the fast (carb heavy or not), environment itself (temperature in particular, causing more or less metabolism to cool or heat the body), stress (heavy stress vs relaxed state)... etc. With that being said, there will never be an exact answer that works for all, since no one can ever share the exact same circumstances. I personally feel that by 48 hours of a fast, my body has begun autophagy. How far along, I couldn’t say. But I also work out very hard, lots of cardio, hot saunas, cold showers, black coffee, and sometimes green tea while fasting, so I know I enter autophagy much quicker that way. 124 Reply 6 replies @thomasdudoso @thomasdudoso 4 months ago I found after 18 hrs I could really feel it. Reply @abbasmukhtar6703 @abbasmukhtar6703 1 year ago This has been a challenging time, and I appreciate you so much Dr Igudia, you have created a life that I thought was lost, thank you so much for curing my type 2 Diabetes 18 Reply @garthly @garthly 2 years ago Surely there is a significant difference if you exercise in the fasted state. I do IF 8 16, but most mornings I run for an hour or so. I have noticed that on long runs at a certain point I can feel my body starting to use fat when glucose has run out. I also notice I feel quite different in other ways. I know if I just sit around I have to fast much longer to get those feelings. 98 Reply 14 replies @karlton7841 @karlton7841 1 year ago When you feel the power kick is signal that you're doing great!!!!! 1 Reply @AngloSaks666 @AngloSaks666 1 year ago (edited) I've experimented with various 'rhythms' of calorie intake over the last few years, also thinking about the type of food I'm taking, also keeping in mind simply ways of getting used to the process (I hit on the idea of using nuts for high calories to get used to small meals, for instance) and it's ended up with me being on OMAD pretty much all the time for about 4 years, a period of one meal every 2 days, gradually getting used to fasting and going from just a couple of days a few times, then 3, then up to 4 or 5 a few times, then 6 a couple of times, then 10 twice, 11 once, then 14 twice, with a month or two at least between each. The key seemed to be getting used to it psychologically, also understanding it (knowing I was feeding myself all the same; also being very aware that getting into the full autophagy and fat burning would be set back to zero if I consumed any food), making sure I was getting the necessary electrolytes for cell function, i.e. sodium, magnesium and potassium, consuming it all the time with water, and just leading normal days that take my mind off of food, that I enjoy, but relaxing. I did it in the summer mainly, and also during holidays, and also while living alone, so that made it much easier. The worst thing is temptation. It's amazing how easy it can get when your body adjusts to it, but the psychological aspect is a big one. I actually would walk past the grocery store nearby all the time and not feel tempted to go in, and even went around the supermarket buying cleaning stuff, but also checking out what best to buy later to finish my fast later, and still not tempted. Results are enlightening. Once fully into it, over the hurdle of the first stages (worst generally is the fourth, I found), better mood, more energy, sharper thinking, better sleep, incredible weight loss (about 4kg per week once properly into it). I lost more than 15kg with this approach. Though, it's true, it made me more relaxed about eating between fasts, so I could have kept more weight off (slow creep sometimes, especially over Christmas). It's true also that doing it with others around, and doing it while working makes it a lot harder. I did it during breaks, long weekends, holidays, and generally alone, keeping the apartment clear of food, of course. I also should add that this developed out of a combination of health problems I was having, plus weight gain, so developed over time and experimentation, so doing it suddenly is maybe not doable. Also I had experimented a lot with low carbs and ketogenic diets, so had gotten used to being in ketosis too, so that maybe made fasting easier for me as well. Also, the fact that I had these reasons and did this experimentation, taking it quite far, is kind of out of some level of desperation, and I can't be sure that the more extreme things I did, the fasts of 10 days and more, etc., do not have some harmful effect, at least in the long term. Short term benefits, weight loss, fine, but I'm still not sure that there might not turn out to be good reason to not take it as far as I did, so 'beware', I'm no expert. Learn about it. Stuff on the channel 'what i've learned' helped a lot in understanding the processes. I think there's more for me to learn, for example what better to eat in the days before it, and how best to come out of it. 56 Reply 4 replies @lisakaye3919 @lisakaye3919 3 years ago Autophagy or not the best I have felt in a very long time is when I did intermittent fasting for a month!!! 34 Reply 1 reply @SenseiEli @SenseiEli 1 year ago I fasted for 45 hours I felt like a new person. I once did a 33 hours fast that gave me a headache.... I am usually not eating for 12-20 hours each day. Eating window of 4-12 hours. Most days 8 hours... But sometimes I am changing because of family dinners etc... My new try is no carbs for one week. 8 Reply 2 replies @bobcocampo @bobcocampo 1 year ago Everyday I exercise in fasted state for 45min cardio 15minutes HIIT, Then Steam Sauna for 30minutes then break my fast after 18hrs of fasting. 10 Reply 2 replies @mangeshdevalapurkar5283 @mangeshdevalapurkar5283 2 years ago Now I am fasting and it is 40th hour. 1 Reply @immortal2326 @immortal2326 3 years ago I guess, most University students experienced Autophagy. When my Case Study due dates and other school report papers piled up, most Friday nights, Saturdays and Sundays , I skipped breakfast, luncheon and dinner. My only lifeline were water and instant coffee. • No Time To Think Of Food; • No time to Eat😁😁😁. All I can think and hope was to finish everything before Sunday midnight 🤪😂😂 23 Reply 5 replies @johnnychomsky2873 @johnnychomsky2873 11 months ago As I do a physical job I just couldn't imagine doing a three day fast Reply @robertbolding4182 @robertbolding4182 1 year ago (edited) I have been running mostly on ketones for the last eight days dropped 6 pounds and my heart rate is way down to the upper 60s at times when I had to fight sometimes to get it below 100 with medication. just checked it's 69. Im taking 1/2 the Metoprolol needed. Doctors dont even know this. I eat one time a day, a little on the light side and mostly protein as to not trigger insulin. I have at least a minimum of 30 more pounds to go so I'm nowhere near overdoing this. I eat dry lettuce as a snack food when bored as it has next to no calories and water sometimes lemon juice in it. for bad breath. I feel good but I feel tired still as I always felt tired but this is better tired. i take a b complex and magnesium and extra salt and Vit C. Edit I have now completed 50 days of eating one meal a day, I have lost 27 pounds max. I feel tired my sleep is poor but my atrial fibrillation is still gone heart rate is so great and I no longer feel like I'm dying 20 more pounds to go. I'm looking more youthful in the face, I'm 65 years old. i had sagging jowls. they are rapidly going away I'm spending more of each day sitting and walking rather than lying down. I always ate what i thought was healthy until i realized carbohydrate is sugar and starch and they are the same thing according to science both are sugar. so eating 900 pounds of starch a year will kill you just as fast. it was my wife's birthday and I took her out and ate normal carbs and got a big nauseating stomach ache. i dont do well eating any corn product and it's in everything. The big bottle of Metformin has gone untouched, on this desk i think I keep it as a reminder. 27 Reply @drkmattrchscake4237 @drkmattrchscake4237 1 year ago What a great voice he has 1 Reply 1 reply @nexusseis7329 @nexusseis7329 1 year ago Try a 3 day water fast and at the 71 hour run a 10K. It was like a normal run. And I think the benefits have improved since that, cause now I can hit the 48HR FASTING without hunger o difficulties. Give it a try. i HAS DONE GOOD THINGS TO MY HEALTH 4 Reply @positivelife3034 @positivelife3034 3 weeks ago Thanks Dr Okter. Reply @LoboBlack187 @LoboBlack187 4 months ago Dr looking gorgeous on this interview, just glowing. Reply @hanslick3375 @hanslick3375 3 months ago His accent is better than that of any Bond villain Reply @TheShazExperience @TheShazExperience 1 year ago (edited) I fast for 21 hrs daily with a eating window of 3 hours and usually between the hours of around 9pm - 12am. Not sure if that’s a good thing, but it seems to help maintain longer deeper sleeps! Maybe I’m a rodent! 😂 The only thing I consume during the fasting window is Lemon Water and Plant Based Teas, some carrot juice.. And.. During the 3 hours refeeding window, I consume Coconut Water, 3 Exotic Fruits, Nuts and Oily Fish, Prebiotic Fermented Foods such as Kimchi, Sauerkraut and Organic Biotic Yoghurt and occasionally a little Rice or Potatoes! Prolonged fasting I’ve achieved 3 days easily and have done it a few times now, however I am now looking to extend from 3 to 5 days in a row soon! This has been my way of life for a while now, and really changed my life forever, by reducing inflammation, weight loss from 75kg to 60kg and my vascularity returned which I hadn’t seen in ages! 6 Reply @delta5288 @delta5288 1 year ago Great info! I'm going to get my pet mice on this program right away. 1 Reply @TheSpecialJ11 @TheSpecialJ11 7 months ago I think intermittent fasting does to your body what high amounts of exercise does, and works so well because we're so sedentary. When I intermittently fast as an office worker who works out once a day, I start to feel like I did as a cross country runner in high school (two workouts a day, plus PE, and a ton of food small meals that fly in the face of intermittent fasting, OMAD programs). I think we all need more exercise and accompanying good sleep and nutritious food, and when we can't get it, less calories and less time processing calories. 6 Reply 1 reply @hectorelmexican4014 @hectorelmexican4014 1 year ago 17 hours 1 Reply @user-qo3mk1ck7h @user-qo3mk1ck7h 5 months ago Just did a 36-hour fast. Even while going through it, had less arthritis pain. Tried to eat breakfast and found that it took less food to feel full. Interesting. Reply @godalmightyismysavior197 @godalmightyismysavior197 3 weeks ago Finish 3 day fast ate pretty bad and thinking about fasting again on Sunday Reply @DudeSilad @DudeSilad 1 year ago Has there been any recent studies since this clip with more evidence of autophagy? I try to do approx 16 hrs fasting. I can lift more weights in the gym so I suspect my testosterone level is higher. I'm in my mid 50's and I see no drop off at all in my strength. I would say my libido is also higher. Which I could do without if I'm perfectly honest :-) 5 Reply @suziewilliams4736 @suziewilliams4736 12 days ago I am 71 years old female. I just came off 91 hours fast today. This is my 6th Fast this year. Usually I break it off at 85 and 87 hours but this time I broke it off at 91 hours. My plans were to stop at 72 hours,. but since I were feeling good I did not want to stop. Fasting is my health benefit program. I did have problems with joint pains lower extremities 2 years ago. But not anymore since I been Fasting the last 2 years . I also uses it to lose wt, but I only lost 5-6 pounds this time . The last 2 days I had the same wt. So I decided to break the fast . I'm a carb sugar eater but my fast has been really helping me. Whenever I notice I have start eating that stuff heavy again I would jump on the Fast to reset. Thank Goodness for this Fasting Thing! PS the 2nd day i'm hungry a lot. I try to drink lots of water. I never experience the headaches, but I do be tired so I can rest. I only did H-salt once , it made me nauseous, I did gatoraide zero once, I didnt like the taste. So I just trys to get through it the best I can to get my benefits. Fasting is my Friend. lmbo Reply @Kuttanwarrior @Kuttanwarrior 1 year ago Thrilling revelation! Congrats,Rhonda! Reply 1 reply @frinoffrobis @frinoffrobis 2 years ago came for the answers,,, stayed for the "i dont know" 🤘 Reply @violet32makingit64 @violet32makingit64 3 years ago (edited) Fasting does gets easier . In the past, I’d binge after a attempted fast , on evening #1 lol. I’m better now :) .Go up bit by bit , like 14 hrs., 24 hrs. , 36 hrs, 48 hr, 72 hrs..... I’m currently doing rolling 48’s , filled by 1 day of keto IF, then another 48 hr water fast ... I’ll be throwing in 3-7 day fasts here and there. I have the body weight to handle this though. There are still great options for smaller people. 19 Reply 1 reply @inkironmojo775 @inkironmojo775 7 months ago love it real science vs hype science! Reply @0vermars520 @0vermars520 3 years ago Fasted for a year now! Gotta have all that autophagy gainzzz 3 Reply @dodumichalcevski @dodumichalcevski 5 months ago I just did my First long fast with 30 hours Just did a good workout and i feel AMAZING 1 Reply @richsalvador5441 @richsalvador5441 6 months ago I love this reaction vid, thank you! I watched this concert when it was released but i keep coming back to her performances especially this one. All these songs are just so special to her you could feel all the emotions in ber voice. Just WOW! Reply 1 reply @westcoastkidd17 @westcoastkidd17 9 months ago it's weird cause the problem I have with extended fasts are that I can't sleep at all. Reply @jcuyoutuby @jcuyoutuby 1 year ago (edited) Besides the hours fasted, would the amount of food and calories intake a make difference in getting toward autophagy? I would think a person with 1200 calories instead of 2000 calories intake before fasting for 20 hours would have better results? And the amount of energy expended during the day. 2 Reply @mbaxter22 @mbaxter22 1 year ago I fell asleep before he got to the info. Great unintentional ASMR, btw. Reply @raykeller @raykeller 4 years ago i watched it like 7 times and not quite sure what the answer to the question was?? oh well i'll stick to my 13 hrs of daily fasting until i understand otherwise. thx 33 Reply FoundMyFitness Clips · 8 replies @saltymonke3682 @saltymonke3682 11 months ago (edited) I'm fasting everyday almost all year long and it's great. Reply @Merc399 @Merc399 4 months ago i think the newest information on fasting in humans indicates that 18 hours into a fast induces autophagy and autophagy begins to slow down at 24 hours fasting 2 Reply 1 reply @mercedezlucke-benedict1122 @mercedezlucke-benedict1122 11 months ago Thank you Reply @shaibh.charles577 @shaibh.charles577 10 months ago What has worked wonders for me is one month in the year I fast 18hrs a day whilst doing medium aerodic exercise( 4/5 hrs)....for the rest of the year OMD in a three hour window for ( 333 - 44 days )... five day straight..Strangely when I cheat I experience discomfort .. Can't say the say for my kittens Peanut, Kiwi and Berry!!! 1 Reply @wmp3346 @wmp3346 2 years ago I think it depends on the person and activity levels 1 Reply @edwardcoyle5425 @edwardcoyle5425 4 years ago (edited) My assumption is, as the body becomes adapted to fasting, fat burning and autophagy it will take longer to reach optimal autophagy.. I make this assumption because it keeps getting easier for me to fast over time. 60 Reply 4 replies @lincolnweller9123 @lincolnweller9123 10 months ago At start of covid I drank a cup of maple sap a day for 3 days , had a can of sardines at day 4 at night and got on my bike left Ottawa to Saskatchewan. Day 5 had another can and made it by the nite of the 7th day . March 8 was a cold ride . As of late one meal days are here for a bit . Reply @yasminkausar5186 @yasminkausar5186 3 months ago (edited) I'm doing 4:20, eating within 4 hours window n fasting for 20 hours ...I've noticed over the last week some small changes already happening...I've been losing a pound of weight every two days and my skin full of blemishes is clearing up, my big toe nails were starting to raise out of shape and they have gone back to a healthy normal...I can't wait to see how much difference it starts to make to my Fibromyalgia and Arthritis symptoms 🤗 2 Reply @daneleva @daneleva 1 year ago Thank you. Reply @go818win @go818win 2 years ago A very smart person ... and doctor as well. 3 Reply @sousafamilygarden @sousafamilygarden 8 months ago Great video's thank you 😊 Reply @thomasrebotier1741 @thomasrebotier1741 1 year ago My (repeated) experience of water fasting is, past the initial stronger loss due to water loss, a loss of 2lbs/day. That's 1.25% of my body mass per day, making the 4-day loss about 5%. I don't know where the number of 2% comes from, it should be revised. 17 Reply 2 replies @daveallan3743 @daveallan3743 6 months ago I'm on a 3 day fast now just completed my 1st day I've done 48 hour fast very easily and omad majority of the time every month do 2mad. Plus walk over 20.000 steps per day whilst carrying heavy items daily 1 Reply @JohnnyLudlow @JohnnyLudlow 11 months ago My rat loved this information! Thanks for asking DR Rhonda. Reply @mikebreler9724 @mikebreler9724 3 months ago My mouse thanks you for this information. Reply @darkglass3011 @darkglass3011 8 months ago I just finished my second 3-day prolonged fast ever last week. It was much easier than my first time. It was probably because I spent 6 weeks getting my body used to fasting from OMAD fasting to alternate day OMAD fasting. I plan to try to push for a 4-day fast by the end of next month to have first hand experience on what autophagy is like. 11 Reply 2 replies @grahamcrawford4203 @grahamcrawford4203 2 years ago 😍😍 Reply @marynguyen9365 @marynguyen9365 2 years ago He's honest. Every body is unique 4 Reply @amsedelm @amsedelm 2 months ago I did 16/8 IF for a few months and my cholesterol went from 204 to 178. It's been 200 for twenty years and IF is the only thing that brought it down. Will keep going and can't wait for what other benefits I get. 8))) 2 Reply @gregorygraham9371 @gregorygraham9371 2 years ago a ten hour eating window with only fourteen hour fast is easypeasy; anyone can do it without difficulty. 2 Reply @waffle_chair9269 @waffle_chair9269 1 year ago Is there any updates on this? Reply @LauraPazzaglia @LauraPazzaglia 1 year ago Three years later, is there any data or new research to extrapolate minimum fasting length for autophagy in other organs, other than le liver mentioned in this video? Thanks! Ciao from Italy, L 1 Reply 1 reply @4nim2 @4nim2 2 years ago I can be volunteer for this experience Reply @theyshouldhavenevergivenme5439 @theyshouldhavenevergivenme5439 2 years ago The question is not answered at all in this weirdly short clip. The title is misleading. 3 Reply @mihaelamihai110 @mihaelamihai110 8 months ago (edited) 😊 Reply @earlgrey691 @earlgrey691 1 year ago Deffo feeling benefits at the 48 hour mark where l believe autophagy really ramps up as well as AGH production which presumably helps the immunity to re-set.My issue is with finding a balance between Ketosis and Autophagy and if or where one cancels the other.I'm good with my weight 10.5 stone at 5ft 9ins and am trying to address a trapezoid inflammatory problem with a meatless (omad) regime long adapted to.I didn't set out to go the Ketosis route but find myself in that state judging by the infamous 'keto-flu' i find myself in,so guess i'm in 'dirt-keto' territory lol. I find it bemusing hearing dr Bergs regular recommended 'grass-fed' meat and eggs protocols but not having the coin for this l just quit the antibiotics ridden corporate farmed stuff and stick with fish which i imagine doesn't by definition get the same 'infusion' treatment as red-meat ?,but generally i'm finding a fry pan of chopped red onion,ton of mushrooms,cherry tomatoes,spinach,garlic and 2 fried eggs ,served on a sesame bagel,sees me good for over 24 hours regularly. I wish there was a definitive,nuanced guide to measure the intersections of a diet like mine more geared to Autophagy and AGH rather than strictly Ketosis but hard to judge if i'm on a self cancelling regime by snacking on a cheese and pickle bagel for example between the OMAD.Don't want to kill myself to live,maybe 2 x 72's a year for an immune reset ? very hard to gauge...conflicting information being what it is ? Reply @phsal5182 @phsal5182 1 year ago thank you Reply @grubbetuchus @grubbetuchus 1 year ago So much for fasting and weight loss. However, fasting has other big benefits, such as the repair and replacing of our mitochondria. 2 Reply @cristie4117 @cristie4117 10 months ago Has anybody ever cleared up endometriosis through fasting? My sister has it very badly Reply @jasonwelsh417 @jasonwelsh417 1 year ago I fast primarily for autophagy. If I am not getting that benefit then I see no reason to do intermittent fasting anymore 4 Reply 1 reply @mrmoe110 @mrmoe110 1 year ago I do at least 16:8 every day but really don’t see autophagy until I get to 20+ hrs fasted. A glucose/ketone monitor is essential! 21 Reply 11 replies @overcomer9392 @overcomer9392 1 year ago What are the needed mg dosages per day for sodium, potassium, magnesium, chloride, calcium, and phosphorus? Long term fast for 3-5 days? Reply @origenjerome8031 @origenjerome8031 3 months ago How about the starving malnourished people in Ethiopia, are they on autophagy all the time? 2 Reply @terrifictomm @terrifictomm 1 year ago Rodent testing is only the first step in testing nutritional hypotheses. They only give us a possible direction to go in. And still, so much awaits us! Reply @bobcocampo @bobcocampo 1 year ago Can fasting, exercise and sauna have autophagy? 1 Reply @marlow769 @marlow769 2 years ago Only 1-2% of body weight lose in 4-5 days? On my 4 day fast I lost 15 lbs which represented almost 9% of my body weight. I’ve done this twice with nearly identical results so what gives with his numbers/percentages? 10 Reply 1 reply @SirFency @SirFency 11 months ago once in autophagy how long should you remain in it before you get diminishing returns on your health? 1 Reply @StraightEdgeJunkie @StraightEdgeJunkie 2 years ago I've been fasting for 200 years now. Starting to see the benefits. 203 Reply 17 replies @junn679 @junn679 8 months ago Days 8 of dry fasting from 5am to 6 pm 22 days to go 1 Reply @TheBowTieCat @TheBowTieCat 1 year ago Fasting has both given me the most gorgeous clear skin I never thought was possible. No expensive creams or any bs 1 Reply 1 reply @wilkensbrito2879 @wilkensbrito2879 1 year ago 🥰Congrtz!!! Reply @RAJOHN-ke7mc @RAJOHN-ke7mc 1 year ago My 84 year old great aunt only eats when she is hungry. She doesnt take any medication. Outside of memory issues (which could be fixed if she stop.drinking juice but she wont) ahe is fairly healthy 5 Reply @JamieHaleyy @JamieHaleyy 3 months ago How does exercise play into this? Like are 14 active hours worth more than 16 sedentary hours? Reply @raciocinionoinercial @raciocinionoinercial 2 years ago When I reduced the period of food intake in the day I started not needing omeprazole or any similar type of medication for my stomach. I also reduced my dependence on ibuprofen. 12 Reply 3 replies @johnnyboy6429 @johnnyboy6429 8 months ago Is our favorite Dr Patrick pregnanz?! 😁 Reply @livthedream5885 @livthedream5885 2 years ago Oh I’m so late to this video! Dr. Rhonda had a baby??!! CONGRATULATIONS. You look adorable pregnant. Blessings! 5 Reply @SonyCamry @SonyCamry 1 year ago Finished 55 day fast feel good but not good Reply @VJ96K @VJ96K 8 months ago I am Hindu but the most fascinating fasting I have seen in Jainism where its called Athai Vrath and they drink only water for 8 days and that too its allowed only twice a day to drink 4 Reply @gingercameronfordcrouch7057 @gingercameronfordcrouch7057 2 months ago What is the maximum amount of time for autophyagee where is doesn't over do it ? Reply @BigSlimyBlob @BigSlimyBlob 3 months ago I don't practice fasting, but I eat all my day's food over a period of about an hour, so I typically go 20-26 hours without eating each day. I've been wondering if this is enough for any autophagy. Reply @douglasquaid7550 @douglasquaid7550 1 year ago I don't have time to watch the video , how long is it ? Reply @krayzeepenis @krayzeepenis 1 year ago What I'm not sure about is how can we do so many fasts if we are a "healthy" weight? Eat in a surplus few days before we fast? I want the health benefits without getting skinny Reply @theseergoddess7774 @theseergoddess7774 8 months ago What about for CAD/atherosclerosis???? Reply @aronchas @aronchas 1 year ago 16:8 with cardio and calistenics in the morning for 45 mins. No need to go more than that because of the workout. For me works wonders 10 Reply 3 replies @BustaDeluxe @BustaDeluxe 8 months ago How long do autophagy last when it reaches the peak before it goes back to the normal level? Reply @stephanM5 @stephanM5 5 months ago Autophagy is dependent on how much food you consumed along with what the macros were whether heavy on protein, carbohydrates and fats during the previous meal plus your level of activity and your individual metabolism. Eat OMAD (one meal a day) and you can pretty much assure you're going trigger autophagy sometime after your meal. Reply @chanhasan3546 @chanhasan3546 3 years ago 30 days 1 Reply @HeartFeltGesture @HeartFeltGesture 10 months ago Benefits for fasting start at 12 hrs, any hours after this is exponentially beneficial. 1 Reply @denniskettinger9900 @denniskettinger9900 5 days ago Fasting in Somalia and the Sudan and parts of Africa seems popular. Reply @spookymonk9046 @spookymonk9046 1 year ago I'm 23 years old. I noticed when I start eating ''Natural foods and lower the carb'' and do 18 hour fast , I get a more stable mood aswell as my craving and sexual impulses become weaker which helps me with my Nofap journey . I still have wet dreams. also my focus is improved alot after 2-3 days of 18 hour fast and eating healthy i notice that. 14 Reply 4 replies @grissom2023 @grissom2023 1 month ago Started doing 24 hr fasts a few times/week.Did my first 48hr water fast 2 weeks ago.Will be attempting my first 72 hr water fast next week. 👍🇮🇪🇯🇴🇷🇺🇷🇺 Reply @bluefish4999 @bluefish4999 8 months ago I've been intermediate fasting couple times a week, 16-18 hours, though I cheat a bit as I drink black coffee in the mornings, not sure if this throws everything off but I've felt amazing. I realized I wasn't eating for 12 hour periods anyway and always though this was unhealthy, so I figured what was a couple more hours, now that I've done it for a couple months I think I can go 24-48 hours. 3 Reply 3 replies @lastraven7205 @lastraven7205 2 years ago so 20 days? Reply @Wolfstalker21 @Wolfstalker21 3 months ago I fasted for 7 days. Each day was always worse than the previous. Never hit a point where I got energy. Reply @nw8000 @nw8000 1 year ago How do you stop the hunger?? Reply @Richard61200 @Richard61200 3 years ago After a short fast 16 hours I had to have a urine test and there was ketones in my urine . I believe 16 hours fast 8 hour eating is better than constantly being in an insulin state . I occasionally do the OMAD . 38 Reply 3 replies @tensaantares @tensaantares 2 years ago Maybe the human brain and nervous system plays a part in the small percentage in weight loss, other than the rodents higher metabolism. 3 Reply 1 reply @makokx7063 @makokx7063 8 months ago So a 2 day fast for a mouse would be roughly the equivalent of a 40-50 day fast for a human being. 1 Reply @normcochran9414 @normcochran9414 1 year ago I'm on the omad diet and that suits me just fine. Reply @seahog32 @seahog32 1 year ago Autophagy is about energy deficit. Run a marathon on an empty stomach and you can expect at least some autophagy for sure. Spent 3 days in bed fasting and there may be none at all. The problem of course is that we have no means of quantifying it in either case. 10 Reply 2 replies @Handle_Not_Available. @Handle_Not_Available. 5 months ago Folks looking to fast for a prolonged duration (2+ days) for the 1st time, just know that the 1st 24 hours are the worst. You are fighting your body's subconscious habbit of stuffing ur mouth every chance it gets. You will not realise how STRONG that urge is until you experience it yourself. But keep drinking water. Water weighs ur stomach and temporarily releaves your urge to eat. You wont die, trust me, your body is just a spoilt lil' brat. Keep going past the 24hr mark, it gets easier from there. Next time would be easier bcz know you know you can do it. Might even encourage some to try a bit longer 36-48hr Only advice, have water ALWAYS around you. Start small. You got this.😊 4 Reply @Jon_8 @Jon_8 10 months ago Does taking a mineral supplement mess up benefits of intermittent fasting? Reply @Doglover-dc1gk @Doglover-dc1gk 1 year ago She asks good questions, the whole video was so accurate, answers were straight forward. This is the kind of videos that's needs to encouraged sometimes. Thank you so much. 12 Reply 3 replies @bryansmith7758 @bryansmith7758 1 year ago can i ask a question? i've heard that long term fasts are hard on your heart, and the body breaks down heart tissue which can lead to heart palpitations. Is this true? what do i need to do to have a safe long term fast? Reply @grandma0077 @grandma0077 1 year ago Do you have any refetences saying that autofagy is not beneficial once a person has metastatic breast cancer? Reply @Gypsyalchemy333 @Gypsyalchemy333 6 months ago Since when is 48 hours 4 to 5 days? 1 Reply @carmieintegrativenutrition9591 @carmieintegrativenutrition9591 2 years ago Eating in a period of 10 hours and fasting for 14 is just a normal day. I often have a 4 hour window to eat and it's comfortable for me. 10 Reply 3 replies @omarsultanov362 @omarsultanov362 6 months ago The lady talked 95% of the vid time. While the answer was "we don't know". Amazing stuff 😂 Reply @kefaskayin1684 @kefaskayin1684 1 year ago This has been a challenging time, and I appreciate you so much Dr Igudia, you have created a life that I thought was lost, thank you so much for curing my Genital Herpes Virus. 1 Reply @ColtraneTaylor @ColtraneTaylor 1 year ago If I fast for x number of days I can come out as an autophag? Reply @gregbell2117 @gregbell2117 4 years ago So we’d be wise to conclude that the mouse fasting regimen that produced autophagy and renewal was nothing like a human 3-4 day fast, due to the vastly different weight losses? 5 Reply FoundMyFitness Clips · 4 replies @Ririgs @Ririgs 2 years ago 1:05 Reply @anowosad @anowosad 2 years ago ... we know! 20 hours intermittent fasting and 4 hours of eating time frame, no high carbs! 3 Reply 1 reply @johnmaloney1681 @johnmaloney1681 1 month ago 3-5 day fasts for most autophagy benefits before diminishing returns is the latest I've heard. Wish there was more definitive knowledge. Reply @paulclark8497 @paulclark8497 10 months ago I've heard that a 48 hour fast once a month or every 2 months is best. Reply @jans8304 @jans8304 3 months ago So how long is the minimum fast???????? Reply @byebyebadman2313 @byebyebadman2313 1 year ago Would it be true that, because you're effectively starving yourself, the body becomes far more alert and agile? Like in preparation to go out and catch your next meal? Giving you the energy and alertness to find/kill your prey? Just a thought i had whilst hungry. 10 Reply 4 replies @daniyalmahdi6156 @daniyalmahdi6156 1 year ago If i do water fast do i eat at night Reply @ludovicosforza9576 @ludovicosforza9576 3 years ago Dr. Patrick, i suggest you name your child Sulfurophane. Greetings from Kamtschatka :) 3 Reply @rickbole6747 @rickbole6747 1 year ago I've been trying to do 5 days each month. As suggested by Dr. Longo as a possibility for people with a chronic illness such as autoimmune. In my case, RA. Hoping to help control/treat my condition, as well as all the desired general autophagy benefits. Who can say for certain at this point? I say based on research so far- worth the effort. Time will tell. 10 Reply 6 replies @kissoffire1 @kissoffire1 8 months ago Normally could do a 4 day fast no problem, but picked up scary symptoms recently after 2 days - short of breath, pale, sweating excessively, dizzy, waves of nausea and tingling down to my hands, with any form of exertion, including a short walk, had to lie down to prevent passing out. Will try again to see if it was just a once off. 1 Reply 2 replies @androidaccount7743 @androidaccount7743 8 months ago So what's the minimum hours according to this video? Reply @stevenr5149 @stevenr5149 1 year ago great video and also great comments. Rhonda Patrick is the rare person who wants to live in a fact-based world in the best way that we currently know. Others would rather get clicks and don't care about the truth. I just finished a 52 hour water fast. feels great. A small amount of salt water helped me avoid headaches during the fast. I recommend to plan your fast so you break it with a few days off work. Just in case there is a bit of inconsistent bowel activity for the first day after breaking it. Reply @JOVI08 @JOVI08 5 months ago I’m dry fasting because of bladder infection. Miraculously it’s gone just 8 hours of dry fasting but will continue to 24-48 hours i guess for complete healing. 1 Reply 1 reply @plifplouf @plifplouf 4 years ago Thanks for the clip Rhonda! I have a question regarding autophagy : it has been said that black coffee helps but you also said that it could stop its process completely? 7 Reply FoundMyFitness Clips · 12 replies @logaandm @logaandm 11 months ago My health and insulin resistance isn't great. I have a very hard time fasting more than 5 days. 3-4 days is pretty easy. This is exactly the information I need. 2 Reply 3 replies @DaddyOKaboom @DaddyOKaboom 1 year ago i already finished like hundred 36 hours fasting sessions, first sessions were hard, i couldn't last more then 24 hours without food, now it's just easy. Now i feel like it's actually sick to not be able to not eat food for like 36-48 hours and function properly. Human organism shouldn't function that way. 2 Reply @melonia4232 @melonia4232 1 year ago 👍👍👍👍😍😍😍🇸🇬 Reply @GizmoFromPizmo @GizmoFromPizmo 1 year ago I'm doing OMAD pretty much every day. Some days are harder than others. Late at night in bed is the worst time for me. I put off eating until around 7:00 or 8:00PM and eat for an hour or two (feeding time). I haven't lost much weight because I've only been at it for 2-years or so but I'm keeping the faith. I do OMAD for weight loss, yes but I do it mostly to reverse insulin resistance. I've been showing better results lately as I have taken off about 5 pounds since November (it's January now). 7 Reply 10 replies @ckbrown9577 @ckbrown9577 9 months ago Having trouble sleeping? Listen to this guy 😂😂😂 Reply @teemothykorneliusmosac8648 @teemothykorneliusmosac8648 2 years ago Would a Vitamin supplement or NAD+, or drugs such as metphormin or testosterone can break the fast and cancel autophagy? 1 Reply 1 reply @vidyamadamanchi7091 @vidyamadamanchi7091 5 months ago What should you eat in the other days when you are not fasting? That is also a question 1 Reply @stevesyncox9893 @stevesyncox9893 1 year ago 23 & 1. Reply @ezequielmgt @ezequielmgt 9 months ago Awesome stuff, I just realized that Mario updated his favorite way to tackle ED and it's crazy! Although what he previously talked about was pretty decent, it was difficult to follow, I just go'ogled the latest in Volpstein’s Thunderous Erections, it's so much simpler and potent now! Reply @Wombat-pv5eb @Wombat-pv5eb 1 year ago I would like to fast 5 days/month and do IF 18:6 the rest of the days for a year. I am a female 53 and I would need daily support (Facebook, Skype etc...) how can I get help ? thanks. 1 Reply @lonnieke @lonnieke 1 year ago thanks for confusing me even more 3 Reply @milanvee3473 @milanvee3473 2 years ago I just finished a 5 day water fast, and I lost 15 pounds, which is around 10% of my body weight. So how do explain this, as opposed to your 1-2%? Granted, I am a long-time fasting practitioner, so maybe this is a factor. 15 Reply 8 replies @ahmetmukavim3 @ahmetmukavim3 8 months ago 16 hours Reply @quigonreturns @quigonreturns 4 years ago Just FYI.. I did the modified fmd as per Dr Valtor longo. For four months consecutively and never felt better. Longo says three to six times a year is beneficial for age reversal. 2 Reply 3 replies @fightfannerd2078 @fightfannerd2078 2 years ago 12 to 15 fast helps the brain I'm remembering things i shouldn't Reply @thomas1942 @thomas1942 8 months ago Ok, so the standard 72 hours of water fasting to reach autophagy. Sounds good, i'll stick to my 4x yearly 7 day water fast. I'm trying to improve my insulin resistance and sensitivity, the weight loss is a bonus but not why i do it. Once i reach my goal weight and my insulin resistance and sensitivity improve to the point i'm happy with it, i'll most likely switch to doing a 7 day fast twice a year. Reply @akshaykumarvyas @akshaykumarvyas 3 months ago What's the minimum calorie count that breaks fasting Reply @robkober9139 @robkober9139 3 years ago My man needs subtitles. 6 Reply @ShaneZettelmier @ShaneZettelmier 2 years ago (edited) I’ve read three studies that were done on humans but they’re not conclusive one said 14 hours once at 18 hours and the other one said 12 to 18 hours. But those tests were not very controlled or clinical, they were more asking questions of the test subjects and I don’t know how they determined if autopagy was starting or not. I find myself when I do the eight hour with 16 hours fasting tend to lose weight a little faster but again that’s not really scientific but from everything I’ve studied I would guess 14 to 18 hours is probably when it starts but I also think it’s probably buried it may start as early as eight hours and 20 hours is probably going to kick it in a lot more than 15 hours, but I don’t see anything very scientific done on human subjects and like this doctor said mice and rats are not humans, they’re designed to eat different food and they’re also incredibly small compared to humans and metabolism and small animals are usually much higher or faster and it’s kind of like comparing apples and oranges. When people ask me I tell them to do what they can do, if they’re comfortable with 18 or 20 hours a day then go for it. A lot of people are fine eating one meal a day or two meals a day. I personally find it if I’m eating the right vegetables with the right fats I don’t get that hungry and doing 16 or 18 hours isn’t that big of a deal, before I was eating the fat with the right foods I was always hungry, I could eat a pizza and still be hungry even though I was stuffed. I think eating right is the Chi more so than worrying about the numbers. I think people should just try to do what they can do, daily I would say 18 hours would be awesome if they’re going to do daily intermittent fasting if they’re going to do it once a week they should probably try to go longer like 2448 hrs., but people really need to stay hydrated and make sure they’re still getting enough potassium and magnesium and sodium so they’re not dehydrating themselves. I drink lemon water and lots of it and I make sure I had plenty of salt before I started to fast, I think taking a magnesium and potassium supplement while fasting is a very good idea, you can also have coffee and adding butterWhile you’re fasting kind of curbs the hunger but doesn’t mess with the autophagy, Some people say you can even have bone broth though to me that seems like your body would see that his food but again I really don’t know we’re having any scientific data on that so I don’t know if bone broth would be OK or not. Reply @eniyemission474 @eniyemission474 2 years ago Im currently having issues with my tendons being inflamed. It hurts and prevents me from carrying my baby or playing with him as i would love to. The doctor diagnosed me to have De quervain tenosynovitis. Will fasting help heal my inflamed tendons? 2 Reply 3 replies @Jacobs_Travail @Jacobs_Travail 3 months ago Anyone know why somebody with insulin resistance like myself who is ridding of it slowly fast 20 hours a day and a couple of 24-hour fast per week has a heart rate that used to be resting in the upper 90s and now low 70s. Anybody know? 1 Reply @garryhelee2151 @garryhelee2151 3 weeks ago This has been a challenging time, and I appreciate you so much #doctorapala, you have created a life that I thought was lost, thank you so much for curing my sister's genital warts I am grateful 🌱🌱🌱........................................................ Reply @muzammilaamir4895 @muzammilaamir4895 1 year ago Im 20 , 6'4 and was 121kg i have been on omad since 14 march dropped 11kgs its the best way to lose weight Reply @karim3163 @karim3163 7 months ago There was a time that i was laughed at when i used to fast for ramadan. Even doctors told my parents that it was dangerous😂. Alhamdoulilah. Ramadan is my favorite month 40 Reply 5 replies @adespade119 @adespade119 3 years ago I would guess at no, or very little, otherwise, we'd all be a lot healthier, because who hasn't fairly regularly, at least once a month, been in a situation where we haven't eaten for a while. I would guess, like anything good, or beneficial there is some hard work and discipline involved. that would tend to indicate more than one day at least. Not a very scientific reason, but... 2 Reply @santallum @santallum 1 year ago I suspect you need to deplete your glycogen and fat reserves up fully before autophagy really gets going in any substantial way 1 Reply 1 reply @ryanpedersen5722 @ryanpedersen5722 1 year ago I wonder if that means humans need alot longer than 2 days then or less? Reply @Tekka579 @Tekka579 2 years ago Did 12 days no food just distilled water and it was good and and ugly. I was fine for the 1st 4 days then weak, then the hunger pangs kicked in and drove me crazy. The stuff coming out of my skin was horrible. Heal a lot of issues eyes got better. I was already lean but I didn't crave sugar as much as I used to. Went from 6 meals a day to only eating twice most days. 9 Reply 3 replies @mariacamilamora-un3bk @mariacamilamora-un3bk 4 months ago In My case about 10 years ago i went to they doctor and put in fasting for two days and a half for a test, after that diet of only water i saw a imprived in My health, i felt verter and Star winning este again Reply @carmieintegrativenutrition9591 @carmieintegrativenutrition9591 2 years ago Most of us prefer to know about humans.. 😂 4 Reply @whattheflyingfuck...6787 @whattheflyingfuck...6787 1 year ago she looked a little pissed that her "prolonged dinner-skipping" is not fasting xD Reply @JBPALU @JBPALU 8 months ago so what is the answer? will 16:8 induce autophagy or not? Reply @jorgearg8701 @jorgearg8701 8 months ago No new info? Reply @60-second-HACKS @60-second-HACKS 2 years ago Can anyone tell me whether a total fast is required to get the benefit, or is severely restricting calories also effective? For example, if I eat a couple of pickled cucumbers during the fasting period (total 16 calories), does that negate the benefit of my fast? 2 Reply 6 replies @aaronthompson1824 @aaronthompson1824 3 months ago 17hours 1 Reply @rivermorrison8383 @rivermorrison8383 3 years ago Wow, so this suggests that intermittant fasting doesn't really induce autophagy. He says you need 3-4 days to reach it? 22 Reply 10 replies @TimmacTR @TimmacTR 1 year ago So what's the answer? What's the minimum length required for autophagy? 2 Reply @Morbutt @Morbutt 3 months ago There have been studies which have shown men's testosterone plummets by over 90 percent when they go on extended fasting (3 to 4 days) so yeah I'll stick with IF or maybe a 24 hour fast once in awhile. Reply @torpedohost @torpedohost 3 months ago i fast minumum of 4-6 hours daily Reply @janetbransdon3742 @janetbransdon3742 2 years ago This answer was given over 2 years ago. So much more research has been done since that time. Dr Berg channel has many updated videos re autophagy, ie proven benefits of fasting. 33 Reply 8 replies @ashfast @ashfast 4 months ago (edited) I had stage 4 cancer, at deaths door. I fasted 2 days straight, all gone!! Miracles can happen. 1 Reply 1 reply @velocitygirl8551 @velocitygirl8551 2 years ago I’m amazed that people do prolonged fasting for weight loss! I do for up to a week every two months but I have MS lol. So interesting. 13 Reply 29 replies @sameday7144 @sameday7144 1 year ago Here’s a question just asking and I’m being serious here, I only feed my dog once a day nothing else and she is over weight, I have been doing that for years she gets the exact amount of food that is recommended for her on what ever I’m feeding her, why does she not loose weight? This is what I don’t understand , I’ve just started IF , I hope I will loose weight and not put it on like my dog does. Thankyou. Reply @JesusChrist5000 @JesusChrist5000 1 year ago I have a habit of sucking mucus out the back of my sinuses (due to post nastal drip?) which i think might be stopping autophagy during a fast. That mucus is protein which has calories, and if you are a mucus back slurper like me, and swallow the mucus, this could be sabotaging your fast. What do you think? 1 Reply 2 replies @oddoneout1835 @oddoneout1835 7 months ago I heard 16 hours. That's what I've been going off of for years based on information from Dr.Berg on YouTube(which wqs followed up by lots of other sources). Reply @buddhaoli @buddhaoli 6 months ago Keto strips usually light up at the 72 hours mark when my system is not all effed up because of glucose fructose. I bet you could maybe get in real ketosis at the 24h mark if you have a clean healthy and constant diet (which is not my case). My 1st recommendation for anybody would be to completely eliminate sugar and maybe carbs from your diet. You'll soon realize how your brain is all twisted up and addicted to sugar (notice that food cravings almost always are about fatty food, junk or sweet things...that's your brain being addicted). Eliminating sugar makes water fasting easier in my experience. +, you are less likely to cheat after your fast. Reply @quequea @quequea 9 months ago Why none of the hospitals implement this? 2 Reply 1 reply @AlephTaV549 @AlephTaV549 2 years ago Can fasting and autophagy reverse baldness? thank you 4 Reply 3 replies @garryhelee2151 @garryhelee2151 2 weeks ago This has been a challenging time, and I appreciate you so much #doctorapala, you have created a life that I thought was lost, thank you so much for curing my sister's genital warts I am grateful 🌱🌱🌱............................................................................ Reply @c.galindo9639 @c.galindo9639 1 year ago Interesting topic. I wonder how autophagy affects those who aren’t heavy in weight 5 Reply 6 replies @davidkim3854 @davidkim3854 2 weeks ago My cholesterol and AC1 is not great according to my last labs from my doctor. Would IF or water fasting help these numbers? Reply @animula6908 @animula6908 1 year ago I think it needs to be reminded that in any individual case, the statistical probabilities may not apply. Unless some scientist has actually used you as his research subject, he’s not going to have evidence of what is going on in your particular body at any given time. This is true of all studies, and even if they studied you it still doesn’t mean they know everything Reply @viktornitriansky9653 @viktornitriansky9653 6 months ago Very time restricted = 10 hour eating window 😂 Reply @scottlamond8569 @scottlamond8569 2 years ago I progressed from 16:8 to 18:6 to 40:8 now I eat once a week, and I feel amazing. 10 Reply 5 replies @scott-richardson @scott-richardson 6 months ago I have started a new regime of simply eating nothing on Saturdays. Meaning dinner Friday, breakfast again Sunday. So about 34-36 hours once a week. Will report back the benefits :) just woke up today on Sunday after no food yesterday. My second week in a row. 1 Reply 4 replies @csmats5374 @csmats5374 2 years ago If a 48 hour fast in mice results in a 20% weight loss that puts mice near death, how is that in any way relevant to humans, let alone equating it to a four day human fast that results in a 2% weight loss? Those data scream that no conclusion whatsoever can be drawn as to how long it takes to get robust autophagy in humans even though both humans and mice are mammals. It's like saying ice cream starts melting at 33 degrees so powdered milk will start melting at [x multiple of 33 degrees] because both ice cream and powdered milk are dairy products. The one data point tells you nothing about where the other data point lies. 2 Reply @MbisonBalrog @MbisonBalrog 8 months ago 4 days for autophagy? That a long time. I may have disappear into deep woods to keep from eating. Or go to Antarctica. 1 Reply @futavadumnezo @futavadumnezo 5 months ago Human body is insanely efficient Reply @patmccarthy1703 @patmccarthy1703 1 year ago I'm on day 3, and all I can think of is fish & chips tomorrow at noon. Reply @brianpowell2798 @brianpowell2798 1 year ago (edited) I just finished a 5 day fast, my mental clarity increased, on day 2. This is my 4th fast in a year, the other 3 were 72 hour fasts. They get easier each time I do them. Must be my body getting used to fasting, also prep before the fast helps. I have a question for anyone. On my 5th day I started getting a general pain in my back, like in the mid section, not any specific location. does anyone know what this could be? Thanks in advance. 19 Reply 20 replies @imalcolm-qc5dh @imalcolm-qc5dh 9 months ago Funny, until recently I hadn't realized that Mario updated his favorite way to tackle ED and it's a relief! Although what he previously suggested was pretty good, it was a real pain to follow... I just go'ogled the latest in Volpstein’s Thunderous Erections, it's so much easier and potent now! Reply @PonchoNOS @PonchoNOS 1 year ago Is there an update on this? Im hearing autophagy begins in 18 hours but maxes our aroun 48-72 @Foundmyfitness 1 Reply 1 reply @charlesh6096 @charlesh6096 1 year ago So, I did 68hrs....did i miss out on the autophagy and renewed immune system? Am rather disappointed in myself Reply @danieleduchene-alessandrin6959 @danieleduchene-alessandrin6959 11 months ago Is only 2% weight loss after 5 days of fasting really worth the pain ? I'd rather stick to 18-6 intermittent fasting. Reply @emelindaortiz8041 @emelindaortiz8041 1 day ago Ito.po ba ay ititigil ang paginom ng.maintainance ko araw araw o.isasabay. -nakabili.na ako sa 2:59 😊.inyo Reply @smileclick @smileclick 1 year ago After fasting a few days, I started seeing lots of children in my dreams, and suspect it’s a way of knowing you are in autophagy - the children are baby cells. I was also having dreams where people were looking through trash to find things - they might be symbols of my body’s microbes reusing old bits and pieces to make new cells (a feature of autophagy). 44 Reply 9 replies @jasonwilcox6637 @jasonwilcox6637 3 months ago 16 hours works well for me, especially when I've been impulse eating like a mad man Reply @johnc.8298 @johnc.8298 10 months ago Dr. Mindy Pelz teaches otherwise. She states that autophagy starts at the seventeen hour mark and increases hourly until max at 72 hours. Reply @hermes8258 @hermes8258 2 years ago Please reduce the twists and turns in your questions 1 Reply @btudrus @btudrus 2 years ago LOL, autophagy is not binary "on" or "off". There is something like a concept of a "autophagial flux" which can be measured. So this is clearly a continuum - on a one hand old diabetic patient with an insane level of insulin (which inhibits autophgay), and on the other hand a human after weeks of fasting. So even a short fast, like 12-14 hours a day may actually matter (especially as authopagy gets constantly less intese with age)... 6 Reply 1 reply @karenblackerby8704 @karenblackerby8704 1 year ago You have my maximum respect Dr Igudia, I am now negative from Genital Herpes virus after I did the test, I wonder what might have become of me it I didn't get the herbal cure From your YouTube channel. God bless you sir. Reply @billcarp3523 @billcarp3523 2 years ago It seems like a good idea to eat 20/4, or OMAD; I do 16/8 or 18/6. I think doing more may be more destructive than it helps. IMO. Humans should eat at least once a day. If for nothing else, so our body clocks stay even. 9 Reply 5 replies @skram1000 @skram1000 10 months ago I am on the last day of a three day fast, my teeth are whiter, I have lots of energy, feel mentally clear and not forgetful, focused. 24hr for sure works wonders for the brain. 1 Reply 1 reply @miketracy9256 @miketracy9256 1 year ago Sounds like 48s are good, 72s are better, and 96-hour fasts may be the Holy Grail. I have done a few 72s but nothing longer, so I will need to work up to that duration. 2 Reply 1 reply @NikoHL @NikoHL 4 months ago (edited) I very much doubt I could fast for 5 days. I live with my family so that would be difficult. Reply @mathewnottingham1006 @mathewnottingham1006 2 months ago Took 3 days before I noticed weight loss with 20-4 IF and rudimentary KETO. By 10 days I’ve lost 13lbs. I’m 3 months away from 68 and this is much easier and more effective than Atkins that I tried20 years ago, plus you really don’t have to buy a bunch of stuff and actually save money on groceries. Reply @halfmanhalfamazing7392 @halfmanhalfamazing7392 1 year ago Autophagy begins after 18 hours, thank you. And I'm a nobody. I didn't finish the 4th grade. 1 Reply @user-yd7we6ou3n @user-yd7we6ou3n 3 years ago Shout out cole snake diet rocks 5 Reply 1 reply @RaymondR-nn8hg @RaymondR-nn8hg 5 months ago Amazing thanks, I just realized that Mario updated his favorite way to tackle ED and it's crazy! Although what he previously talked about was pretty decent, it was difficult to follow, I just go'ogled the latest in Mario Volpstein’s Thunderous Erections, it's so much faster and lasting now! Reply @akbarshoed @akbarshoed 1 year ago No one ever asks: Why Autophagy? How "backed up" could our cells possibly be? Reply @johnnikoloudakis1428 @johnnikoloudakis1428 1 year ago 44/4 Reply @rbgsista9236 @rbgsista9236 8 months ago To me 18 hours is the safe space where autophagy begins Reply @pepsodentvanila @pepsodentvanila 8 months ago I've tried fasting. But my stomach ache. The acid in my stomach makes me not comfortable Any ideas how to solve this ? Reply @begula3013 @begula3013 3 months ago (edited) Started fasting two days a week (Mondays and Fridays) and eating enough calories on the other days to make up for it. My injuries are healing to the point I can start exercising again. I'm off kinesiotape and I look years younger, lighter than I've been in years! Praise God for this discovery and for the gift of fasting and prayer, and prayer walking! 4 Reply @meskalin64 @meskalin64 1 year ago Ive heard doses around 400mg trans resveratrol triggers autophagy. Whats your take on this? Reply 10 replies @aopLib19 @aopLib19 6 months ago So, are you suggesting that there is no benefit as far as autophagy for time restricted😢 feeding with perhaps..... a 7 hour feeding window? I see that this discussion is 4 years old, and I believe I've seen newer research that indicates you can get autophagy within 24 hours..... perhaps less. Your thoughts? Reply @verfassungspatriot @verfassungspatriot 2 years ago (edited) What about only eating foods which are high in spermidine for a certain time period? I will try that! Reply 1 reply @whoknows8223 @whoknows8223 1 year ago When I was 21 I had some issues with my teeth and could only eat icecream and yoghurt for 4 days. I lost 5 kg (73 to 68 kg) in these 4 days. Thats almost 7% of my weight back then. I don't know where your 2% number comes from Reply 2 replies @williamjohncharlesdavies5049 @williamjohncharlesdavies5049 1 year ago Did she say 48 hours is 4 days? Reply @kevinadamson5768 @kevinadamson5768 2 years ago I've done a 48 hour fast a few times and didn't feel hungry at all, might try a 72 hour one next. 5 Reply 1 reply @pandurangrotithor @pandurangrotithor 1 year ago Pranayam is the best way to increase circulation of scavenger cells The pelvic veins don’t have valves This facilitates rapid circulation by pranayam Various methods of pranayam employ different muscles of respiration to churn the blood Dr Rotithor Reply @a_m4608 @a_m4608 3 months ago I have two meals in window of 3-9pm,I've skipped breakfast entirely,I'm feeling good since few months. Ideally I'd prefer to having an eating window of 12-6pm...but I'll get there eventually. Excess food becomes poison to your body. Fasting does wonders no one can convince me otherwise Reply @ukraine7249 @ukraine7249 5 months ago I’m a rodent locked in a research lab and currently being starved! Please help!!!!😢😢😢 Reply @ramblinman4675 @ramblinman4675 1 year ago I did a 72-hour water (snake juice) fast last week and I must've done it wrong because not only not have any energy at all I got more tired each day. Also I started hurting in joints that normally don't hurt. Barely had energy to get out of bed. I did it to get rid of stomach pain I think I got from listeria (ate 12-15 bags of salad kits 3 weeks prior that were recalled that I didn't know about) but I still have that abdominal pain. Had normal energy before and after. I lost 5 pounds and saw it for sure. I made up a container of pink Himalayan salt, no-salt, and Epsom salt (snake juice recipe) a year ago and still had some so I used it. Can that stuff expire or go bad? Just wondering why I had no energy. 1 Reply 8 replies @catwhite8614 @catwhite8614 9 months ago 48hrs means 4 or 5 days???????? Reply @Chris-vc1dh @Chris-vc1dh 1 year ago is fasting a good way to fight bacterial infections? 3 Reply @ralphacosta4726 @ralphacosta4726 3 months ago Amazing that humans can just continue life while fasting, apparently unlike rats. I've done fasts of various types (3 day, 5 day, seven day water fasts, alternate day, a fasting-mimicking diet following Dr. Long's guidelines, and these days eating between 9 and 11 am most days) for decades and i'd just continue my running and exercise schedule with no apparent problem. I even fasted on a marathon day and noticed no apparent difference. But i was only in my 60's when i did the marathon fast. Now i'm 81and don't do the water or fasting mimicking fast because my wife worries about my weight, so i keep a few extra pounds on to make her happy. I also do a Ferris Bueller Day Off once a week. On normal days i eat lots of meat, dairy, some veggies and fruit, a potful of supplements, and minimum of 50 gm fiber. My doctor says i'm an exceptionally healthy guy, but my older brothers seem to be too, so i'm sure a good part of it is having great genes. 1 Reply @yourmom9608 @yourmom9608 1 year ago AFTER READING BOOKS ON JAINISM ALMOST ALL THE DOCTORS WORLD OVER WANTS TO SUGGEST THE SAME THINGS IN DIFFERENT MANNER Reply @lightbeingpontifex @lightbeingpontifex 1 year ago i think it starts at 16 hours ,,, 1 Reply @ZenMasterNahc @ZenMasterNahc 3 months ago After I got out of the hospital from heart complications, I was asked if I needed anything from the store. I said yes, and asked for cucumbers. Next time I asked for broccoli. I wasn't asked what I wanted anymore. My grandma just started buying Donuts, pastries, cookies, ice cream, and deli sandwiches with the thickest whitebread bun I've ever seen. I honestly didn't think she was this ignorant. I still don't believe it actually. I'm more inclined to think she just doesn't want me to be healthy. What is love? Lol Reply @Kathy-kr1sv @Kathy-kr1sv 10 months ago Autophogy according to Dr fung starts at 17 hrs. Up to 72 hours Reply @larrytate1657 @larrytate1657 4 years ago We don’t know shit basically. 6 Reply 1 reply @MrJohnTomlinson @MrJohnTomlinson 1 year ago After 10 days on a water only fast I started to get pain in my hips, lower back and sciatic. During the day it was no problem but this pain would seem to intensify at night when I laid down and I was unable to sleep at all the last two nights. I have stopped the fast until I can understand this more. Does anyone else with extensive experience know what causes this and possible remedies? I was doing great other than this. After a post fast broth and fresh vegetable juice regimen I fully recovered in 3 days. Reply 6 replies @ralphmorgan6130 @ralphmorgan6130 2 years ago Short answer - more than 8-12 hours. Not snacking after dinner is not a 12-hour 'fast' ;) 3 Reply @preethoo5 @preethoo5 1 month ago I'm on medication for diabetes & high blood pressure: is it advisible for me to do intermittent fasting? If yes, shall I take my medication as normal? I would appreciate an answer. Reply @efivos5362 @efivos5362 1 year ago The answer is very simple. It depends on the organism. For one who fasts regularly and follows a healthy diet it's probably less than someone who never fasted and their body is not even capable of producing ketones relatively fast. BTW, women, be careful of your intermittent fasting and water/dry fasting patterns because you do not want to burn too much fat every day. You are made to carry more fat than men and this is how you stay healthy! What Rhonda does (10-14) is the best, but don't do it forever. 8-16 for women it is proven (in practice) to be extreme. And mind to take all your calories cause on a 8-16 or 10-14 diet with calories deficit is kind of dangerous when done for long periods. 5 Reply @therecogniser2122 @therecogniser2122 3 months ago Why minimum and not maximum? Reply @thor4164 @thor4164 3 years ago 48 hours for a mouse is like 48 days for a human lol 5 Reply @mikekisonu6825 @mikekisonu6825 3 months ago Somehow, science said in a GERMAN accent seems that much more BELIEVABLE. 🧐😆👍🏼 Reply @buybuydandavis @buybuydandavis 1 year ago I can never find the answers to the obvious questions about intermittent fasting: What actually breaks the fast? How many calories? Of what type? Do we have measurable indicators of being in a fasting state, and getting out of it? 1 Reply 2 replies @grantlikes2sing @grantlikes2sing 4 months ago In the last four years since this video was made is there an answer to this question yet? Reply @jeojoy1897 @jeojoy1897 1 month ago Thanks #Doctorapala, I've been diagnosed with herpes and it really is scary and heart breaking but understanding it and the stigma is the worst part honestly…………………………………………………. Reply @AR-YouTube. @AR-YouTube. 1 year ago Does Autophagy heal diabetic retinopathy? Reply @adambarns2496 @adambarns2496 3 years ago 14 hour fast!! Wow careful sweetheart... 5 Reply 4 replies @mabaltimore5401 @mabaltimore5401 3 months ago He said fasting during the day has more effect tha fasting during the night. That is exactly the Muslim fasting. There are are one month every year for mandatory for those who are physically able. And is recommended twice a week (Mon, Thur). Reply @davidhines68 @davidhines68 1 year ago It should be pointed out that abnormal fasting isn't necessary to have autophagy. Reply 1 reply @endofspecies7575 @endofspecies7575 3 months ago I used to fast but now my syphilis kills of any new diseases. Reply @magdanieniewska2687 @magdanieniewska2687 1 year ago I was actually very happy when I heard Dr. Longo speak about the benefits of a 12/12 hours fast as opposed to longer fasting periods that also have specific health benefits, but also have increasingly more negative side effects (the longer you fast). He also mentions studies that show, that people who skip breakfast (which is very common for those who fast for extended time periods) have a shorter life expectancy than those who don't skip breakfast 🤷‍♀️ Do whatever feels right for you... but I'm done with longer periods of fasting. I gained absolutely no positive effects off of them. 5 Reply 8 replies @kelvsOse @kelvsOse 6 months ago Is it right to drink water when fasting? Reply @MoeJoe974 @MoeJoe974 1 year ago Sorry, I had to turn this video off when the interviewer took almost half the video to ask the same question over and over without letting the person who knows the answer actually speak. 4 Reply 1 reply @cwcfunclock2709 @cwcfunclock2709 9 months ago Whenever I fast, my mom starts cooking delicious foods. According to her point of view, Panda is healthier than a skinny cat. Reply @samhermans8236 @samhermans8236 9 months ago I think it’s so weird people calling not eating for 12/14hours at night fasting. That’s not fasting to me. That’s healthy eating, how I’ve been taught and what I’ve been doing for the majority of my life. Reply @garycortesi8406 @garycortesi8406 6 months ago Does using heavy cream in my coffee break my fast? Reply @ekoi1995 @ekoi1995 1 year ago Studies have shown that autophagy may take two to four days of fasting in humans. It is believed that autophagy does not begin until the glucose and insulin levels drop considerably. Some experts suggest starting with 32 to 48 hours; 72-hour fast autophagy pushes the limits for most humans but can be possible. Depending on the individual's metabolism, significant autophagy may take two to four days of fasting in humans. How do I know I'm in autophagy? Increased ketone levels. Ketone bodies are molecules produced from fatty acids when your body doesn't have enough carbs to use for energy ( 7Trusted Source Trusted Source ). ... Reduced appetite. A key sign of autophagy is reduced appetite. ... Fatigue. ... Bad breath. ... Weight loss. ... Improved brain function. Reply 1 reply @franktemplar6290 @franktemplar6290 1 year ago 48 hours is 4 days???? Reply @faridsaid9180 @faridsaid9180 2 years ago 60 days is a complete cycle of autophagy 3 Reply 1 reply @4406bbldb @4406bbldb 1 year ago About 35 hrs. But I assume you are fat adapted. I’m currently at 48 hrs and this is the easiest fast ever. I’ll likely 🛑 tomorrow but I’m really in Cruze mode, I listen to my body so I’ll know when to quit. It’s the refeeding i have trouble with. 1 Reply 1 reply @joincapt.matthew5528 @joincapt.matthew5528 1 year ago Give me a break. It's easy to find out. Simply get keto strips from Walmart or Target for under $8. Generally, after 18 hours fasting you will see some results, either trace or small ketosis. After two or three days you are in full ketosis. You don't need some clinician or doctor or some scientist to tell you what you can measure yourself with keto strips when urinate! Geez Louise, it's that simple.! Test it yourself. become curious. Be your own citizen scientist! It really is that simple. 5 Reply 3 replies @meditationandhealingwithse1827 @meditationandhealingwithse1827 1 year ago 🙃 Reply @asociatiaademed7417 @asociatiaademed7417 1 year ago Eating 5-10 times a day is detrimental to health anyway. "Fasting" is just an word for not eating. There is a lot of noise around autophagy, which could exist or not. Nevertheless, most scientists and practitioners consider that eating 2-3 times a day and reducing the intake of carbs are healthy choices, no matter what diet or lifestyle. It does not have to be extreme, is good enough to be moderate. Except medical cases, of course. Reply @MrRaysuli @MrRaysuli 1 year ago Is this still correct?? Please Reply @sup3rbird @sup3rbird 4 years ago The question was about autophagy, not weight loss. WTF? It's my understanding that autophagy (self-eating) means that damaged cells are cleared out and are processed to help regenerate new cells. What has this got to do with weight loss? 6 Reply 1 reply @theredpriest @theredpriest 8 months ago in other words, you're not going to see significant results from autophagy. It can "help: but it's extremely minimal and the results don't warrant the practice. Because most people aren't going to go without food for 3+ days just to see a 1~2% reduction in body weight/cell waste. Reply @tuhinkkumar2596 @tuhinkkumar2596 8 months ago I wonder how Hinduism became such a scientific religion hundreds of centuries ago. In Hinduism fasting is the fundamental thing related to every puja we do, there are even some fasting rules where they don't even consume a drop of water 🙏🏻 Reply @oibal60 @oibal60 1 year ago I'm a rookie. I'm doing 14 hour blocks. Reply @alkeegan9915 @alkeegan9915 4 years ago Sadly I am starting to think a person pretty much has to starve themselves to near death in order to see any benefits. What he says about the percentile reductions in humans being about 1% after a prolonged fasting period just doesn't inspire confidence. I do 16:8 regularly and a 24hour fast once a month. I'm starting to think that it's not as beneficial as I'd hoped. 13 Reply 7 replies @waterca178 @waterca178 1 year ago Let the man speak Reply @stugryffin3619 @stugryffin3619 1 year ago Answer at 1:05 3 Reply @Altegore @Altegore 2 years ago What I wanna know is - how does one water fast...and do powerlifting at the same time? Is it detrimental to health like that? Reply @DC-wp6oj @DC-wp6oj 1 year ago So a person weighing 150lbs would have to lose 30lbs during fasting to show the equivalence to rodents. At an average loss of 2lbs per week it would take around 8 weeks to see the autophagy humans expect. Thats far more in line with respect to metabolism in rats/humans. Hence even 3 or 4 days is no where near the tome needed to have the effect we would want. Until we have real human studies. Its all guesswork. Reply @bobcat8654 @bobcat8654 9 months ago Can he get to the point what is the amount of time Reply @elonmusk6654 @elonmusk6654 1 year ago She formulated her question wrong. She asked if humans had a faster metabolic rate than mice. But Humans lose 2% of body weight in 4 to 5 days, where mice loses 20% at just 48 hours, therefore, actually, mices have a humongous faster metabolic rate than humans. Reply @alicomando1195 @alicomando1195 2 weeks ago (edited) Do large and tall people need more calories than short people? Reply @toddvolpe6396 @toddvolpe6396 3 years ago Oh my God what happened to her? Oh, nevermind. My wife told me, then she slapped me on the top of the head. 5 Reply 2 replies @datsuntoyy @datsuntoyy 2 years ago Just an FYI, cats can die in 1-2 days if they fast. They go into a condition called hepatic lipidosis. So now you know how longs rats and cats can fast. Reply 3 replies @damiandamiano3651 @damiandamiano3651 1 year ago Dont delude yourself, 14, 16 hours is nothing, 24 while you work out is something Reply @reubenkolo852 @reubenkolo852 1 year ago I gat you for life doc. Gboya on YouTube You are a life saver I really appreciate your good work in my life 👍🙏. Reply @matthewharrigan3568 @matthewharrigan3568 6 months ago Zero. Autophagy is always occurring while you are alive. The rate does vary though Reply @sofiya7786 @sofiya7786 1 year ago It takes 3-4 days 1 Reply @zze4344 @zze4344 2 years ago I am fasting 1 month in Ramadhan every years..Almost 30 years from age of 10 year old..For us the benefit for fasting is very good.Our condition body is very good after 1 month of fasting..in one days we are fasting without eat and drink almost 13 hour perday..is not included when we are sleeping for bedtime in our ruttine..everyday for 1 month .I am muslim. 3 Reply 3 replies @ceeemm1901 @ceeemm1901 5 months ago Rhonda obviously isn't a fan of fasting. 1 Reply @davidrosenthal5795 @davidrosenthal5795 9 months ago I feel bad for people who go down these rabbit holes. Such western silliness. Eat appropriate amounts (most people eat way too much) and workout daily with couple harder workouts a week. Then you can watch videos like this and think…. “Whew that is insane” while eating ice cream. Reply @napndash @napndash 1 year ago 10 hour eating window LOLLLLL Reply @lizw2853 @lizw2853 7 months ago Be careful fasting for long periods can kill you. The Irish hunger protesters died in jail after about 48 days! The Scottish man was morbidly obese and his fast was medically supervised. The dead won’t be here to comment about it. I’m fasting too but not to extended lengths. Please be careful 1 Reply @Laurendoesflips @Laurendoesflips 1 year ago aww yes MINIMUM time please Reply @billcarp3523 @billcarp3523 2 years ago WOW! I just completed a two week fast!...The emergency room told me I should eat more often. 4 Reply @oki484 @oki484 7 months ago As Vivekananda said, the more world advances in science, the more they know how advanced was Hinduism in every aspect. Reply @ScribblyDoodle @ScribblyDoodle 9 months ago (edited) I'm on day 4 of a 5 day fast, and I keep being told that after day 2 it gets easier and I should have more energy, but so far this has been the hardest day for me. The hunger pangs are stronger than ever, no energy whatsoever. Can barely keep my eyes open. Been taking electrolytes and apple cider vinegar mixed with water. I don't understand everyone saying how much energy they have. This whole experience has just gotten worse each day and I feel like a zombie. No fasting energy. No mental clarity. Only discomfort, extreme hunger and misery so far lol. And my hemorrhoids are as present as ever, which is why I started this fast in the first place. Am I the odd one out, or is everyone else just crazy? What is supposed to feel good about this? Honestly it's just making me depressed. 1 Reply 2 replies @geraldfrank1630 @geraldfrank1630 2 years ago GAPS 🙏 1 Reply @dikarabarcah @dikarabarcah 6 months ago As a moslem, it is my obligation to fasting full a month during Ramadhan, No food, no drink, no sex, starting dawn until the evening.. we enjoy it that month so much 😀 2 Reply 6 replies @sainigagan5 @sainigagan5 1 year ago What did they really discuss?? Reply @yesminister6736 @yesminister6736 2 years ago Honestly 16:8 is like for rookies ... I don't evn feel it. Omad is great (most folks won't need anyothr workout besides walking 8k+ steps a day) . If u are vegan/vegetarian Omad will be more challenging. Remember, only meat eaters (high protein high fat) can fast dat long on routine basis. Vegetarians shud prefer 16:8 or 18:6 and work out when fasted (also keep, second meal at night relatively low carb). Anybody can try long fasting every now n then. Modi (ind pm) eats less, sleeps 4 hrs tops and fasts during certain religious ocassions (for 7 days 9days etc, only lemon water). 3 Reply 1 reply @NiCoLe77A @NiCoLe77A 1 month ago I’m trying for the first time to do 7days water fasting; I stopped eating yesterday at 5:30pm… let’s see how I progress. I’m doing it for 2 reasons: 1. Weight loss (never bad 😅) 2. I have lots of fibroids and I want to see if it’s beneficial. I also do 18/6 or 20/4 or 24 intermittent fasting. Let’s see 🤗 Reply @bruceames9224 @bruceames9224 1 year ago So you have kept your podcast and taking no risks in the face of the pandemic. Good for you, you have an income. I wonder if that nagging question in the back of your mind, that ability of yours to delve deeply into scientific data, has prompted you to look at the information that has continued to come out in the last two years about Covid. Does it keep you up at night that you’re actions might actually reflect cowardice in the choice of safety and following the narrative over actually educating people about what their health and fitness is? 1 Reply @josephfarrugia2350 @josephfarrugia2350 8 months ago TL;DR? So what's the minimum time one should fast for autophagy? Reply @wtf859 @wtf859 6 months ago Also keep in mind that it depends on the Individual their body’s and their lifestyle. If you just Sitting all day in the office and don’t workout it’s a different story and maybe much easier. But if you workout a lot you should at least eat after that because your body need those minerals, mikro and macro for regeneration. 1 Reply @boiragirules @boiragirules 3 months ago 4 days 96 hours. Reply @gloriaiarango @gloriaiarango 4 years ago (edited) AAhhh those scientist!!! Instead of using mice why they don't use humans? I have fasted for 20-48-72 hours -five days and 12 days. Nothing happens in the body before 72 hours, after that your toxins, autophagy start to clear and you lose weight and you can see your skin, gums, hair, eyes,etc start to change. I lost 13 ponds, (I'm 60 yo)and everything was wonderful!!! Highly recommended! So for this doctor to say they can't know about results in humans let me tell you I'm not the only one doing this, here in youtube he and everybody else can find human fellows doing this, they are just lazy and then they don't recognize anything that is not "supported" by their well founded labs (usually by universities and pharmaceuticals behind them) 13 Reply 13 replies @john2914 @john2914 1 year ago A dry fast is reccomended over a water fast. Reply 1 reply @z00011001 @z00011001 2 years ago You just have to avoid protein for autophagy. It has nothing to do with fasting. It has to do with protein fasting. Of course ketones are required. So you cannot gorge on carbs. Just follow Omad at min and avoid proteins on weekends or more. Reply @ginachristidis @ginachristidis 3 months ago 48-72 Reply @TheLuminousOne @TheLuminousOne 8 months ago (edited) I just completed a 144 hour water fast. Piece of cake. I was 154 lbs i now weigh 54 lbs! Reply 2 replies @logical_lb3059 @logical_lb3059 1 year ago I didn't understand a word he said :( Reply @neven3000 @neven3000 4 years ago Gee thanks for NOTHING!!! 6 Reply 3 replies @freshlime7538 @freshlime7538 1 year ago Islamic fasting strictly should be through out the day and you only can eat after sunset, which supports this study. Reply 1 reply @thetheraine @thetheraine 8 months ago why is a few days considered a long fast now... when decades ago, people went for weeks without eating... to heal illnesses, diseases etc and big weight loss... 1 Reply @TheStig6662 @TheStig6662 8 months ago OMAD gang 🎉 2 Reply @HealthTalkBOSS @HealthTalkBOSS 5 months ago 72 hours Reply @sonofa1000fathers @sonofa1000fathers 1 year ago If you wan to know more precise info on when autophagy and other fasting benefits happen, I would suggest Dr. Sten Ekbergs vieos on the subject. Also, 1-2% of weight loss in 4-5 days is plain wrong. I have fasted often and noticed 4-5% in 3 days. 1 Reply @estuchedepeluche2212 @estuchedepeluche2212 1 year ago I have been fasting for the last 72 minutes, I think I am done. 2 Reply 1 reply @felipearbustopotd @felipearbustopotd 9 months ago Any time that the stomach is devoid of food (usually 5 hours after eating) has to be beneficial, yet too many shovel food in like a conveyor belt. No wonder we have problem... a big HEALTH / FAT problem. Reply @MorganBlem @MorganBlem 5 months ago He sounds like "My name is Giovanni Giorgio, but, everybody calls me Giorgio" 1 Reply @johnhopkins3406 @johnhopkins3406 1 year ago So he cites one study. Yeah he is the authority. Reply 1 reply @destroya3303 @destroya3303 1 year ago Well now I know how to induce autophagy in rats. 1 Reply @toroyoko @toroyoko 4 days ago Day 2 of my fast, I had a dream that I was eating a nice juicy steak lol Reply @parapoliticos52 @parapoliticos52 3 months ago Guido is Zen Reply @ziaulislamchowdhury1113 @ziaulislamchowdhury1113 9 months ago 8pm to 8am is okay?. 12 hrs fast.... Other meals in between as usual Reply @ziaulislamchowdhury1113 @ziaulislamchowdhury1113 9 months ago 8pm to 8am is okay?. 12 hrs fast.... Other meals in between as usual Reply @marshellebackes @marshellebackes 3 months ago Poor audio, lack of graphics to support audio. Reply @momsberettas9576 @momsberettas9576 1 year ago So... what was the answer? Reply @jennaranna9536 @jennaranna9536 1 year ago I got healed from hsv1/2 introduction and the response of #Doctorapala when I saw recommendations ,Proud to be an African American.. Reply @bokkenrijder172 @bokkenrijder172 8 months ago 3 minutes, yet no answer given. 😆 Reply @LuminousMindGames @LuminousMindGames 2 months ago I fasted for 3 days and lost 15 pounds from about 205 to 190 Reply @jennaranna9536 @jennaranna9536 1 year ago I got healed from hsv1/2 introduction and the response of #Doctorapala when I saw recommendations ,Proud to be an African American.. Reply @lawrencemaweu @lawrencemaweu 10 months ago Autophagy starts from 18 hours of fasting. 1 Reply @googleunivers @googleunivers 7 months ago If no autophagy was detected on mice that got rested during the day doea that mean that, normal sleeping hours for human do not help achieve autophagy ? Reply @jennaranna9536 @jennaranna9536 1 year ago I got healed from hsv1/2 introduction and the response of #Doctorapala when I saw recommendations ,Proud to be an African American.. Reply @ericlawrencehenry @ericlawrencehenry 1 year ago If you look at UK broadcaster and intermittent faster Dr Michael Mosley (65) - you can see the benefits. Reply @YSLRD @YSLRD 1 year ago Danny Kaye is still alive! Reply @joychaudhuri8782 @joychaudhuri8782 3 months ago What language is this man speaking in? Reply @Macheda4Life @Macheda4Life 2 months ago The goof feeling the day after 3 day ccocaine benders start to have an explanation now. I wanst a drug addict i wws just fasting 😂 Reply @therealtulip @therealtulip 10 months ago This short clip didn’t really answer the question in the title. Reply @adamstewart8712 @adamstewart8712 6 months ago … Reply @florrie8767 @florrie8767 3 years ago Google professor Roy Salford he did this year's ago. For years Highly nutritious frugal diet plus fasting. He said humans cd live to 120 based on mice studies.. he died age 80 of motor neurone disease Reply 1 reply @michaeljames63 @michaeljames63 8 months ago Vely Interlestink! Reply @tonyr.4778 @tonyr.4778 4 months ago This interviewer said "48 hours is like what, 4 days?" Wtf! Hour many hours in a day? She is so dense as to not know how many days is 48 hours. Reply @AS-pug @AS-pug 6 months ago So… what’s the answer? Reply @EngineeringMadeEasy @EngineeringMadeEasy 1 year ago Can anyone tell me- Will fasting help in anxiety issues? Reply 2 replies @amirsyarifuddin9544 @amirsyarifuddin9544 8 months ago Dry fasting, right? Reply @RunnerThin @RunnerThin 2 years ago Why post this? Did not answer the question. What is minimal fast for cell cleaning. His answer was we don't know. Reply @srinivasankannan8428 @srinivasankannan8428 11 months ago w=why is house md doing research Reply @FeralFaeRae @FeralFaeRae 1 year ago Wow to all you people who can fast longer than 16hours!!! I'm upto 17 lol 1 Reply @benv.5170 @benv.5170 1 year ago It's 30 hours Reply @tomgold5006 @tomgold5006 1 year ago I’ve seen ghost with more skin color 2 Reply 2 replies @avelocidadmaxima @avelocidadmaxima 1 year ago I hit the LIKE button .. But i don't understand anything what he says Reply @Sphynx93rkn @Sphynx93rkn 10 months ago How often do you guys poop if you fast? Reply 1 reply @fotoyartefotoyarte1044 @fotoyartefotoyarte1044 6 months ago guys I think I am a softy, I fasted for 26 hours and I feel A LOT OF HUNGER; I also feel weak. I will go to sleep to achieve 36 hours, but what the fuck, this is hard. How in hell do people fast for more than 40 hours? Seems I would faint and die Reply @Huy_Nguyen_USA @Huy_Nguyen_USA 1 year ago Let your guest speak! Reply @randomanonymoushuman @randomanonymoushuman 1 year ago Doesn't actually give an answer? suggests 3 days possibly. Reply @andreaskling2201 @andreaskling2201 3 months ago In short,they dont know. By the way,how can you compare mice and man? Reply @michaeltubbs4606 @michaeltubbs4606 1 year ago She spent a minute and 5 seconds asking a question that was answered with "We don't know". Couldn't they get together on this question/answer thing before starting the video? Reply 1 reply @beliebigerusername @beliebigerusername 1 year ago Kurt Kroemer ist der Beste! Reply 1 reply @silverstake88 @silverstake88 1 year ago Huh!?! 48 hours is 2(two) days..... 1 Reply 1 reply @rodneysammons5544 @rodneysammons5544 1 year ago Need to add Prana to all the what about this what about that. Fasters have increase in energy levels without consumption. Reply @healthfitnessbysuman6602 @healthfitnessbysuman6602 1 year ago What is the answer? Reply 1 reply @peek-ka-boom6017 @peek-ka-boom6017 7 months ago DOES AUTOPHAGY ACTIVATES IF YOU'RE FAT? Does Autophagy happen even if you have thousand and thousand of stored calories? 1 kg of fat is 7700 calories. An average male has 12.6 kg of fat reserves. That equals to approx 117,000 stored calories for the cells. I mean cells won't eat fellow cells if there's abundant reserves in the body. That's a 70 day supply of fuel for the cells. Does autophagy only turns on after you have depleted your fuel stores (in this case 70 days)? 1 Reply @olfoogy @olfoogy 1 year ago so.....was there an answer to the headline question? Was it...no? Reply 1 reply @jajupa78 @jajupa78 3 months ago Can we do a study where we fatten up the mice to an obese level first. Then make them fast... bet they won't die in 3 days... Reply @peek-ka-boom6017 @peek-ka-boom6017 7 months ago So 48 hours of mouse fasting = 20% reduction in body weight This equals to 480 hours (20 days) of human fasting = 20% reduction in bodyweight 2 Reply @paulamaldonado4729 @paulamaldonado4729 3 years ago Does chicken or beef broth break a fast? Reply 7 replies @zarmindrow5831 @zarmindrow5831 6 months ago Coffee enemas get it going a lot faster! Reply @ladyinred9656 @ladyinred9656 10 months ago Autophagy starts at 18 hours 1 Reply @gt-gu7rb @gt-gu7rb 1 year ago (edited) So you don't know? I didn't watch this to hear I don't know 😕 Reply @creativesource3514 @creativesource3514 8 months ago The people commenting on this thread don't seem to have listened to this professor on the evidence. The bottom line is we don't know when autophagy kicks in. Reply @jcojrDTG @jcojrDTG 1 year ago speaking of pregnancy babies share stem cells with mothers Reply @yehmiyah @yehmiyah 3 years ago HalLeLuYAH 1 Reply @clarke6808 @clarke6808 1 year ago she fasts for 14 hours guys and sleeps for 8 of those. WOW Reply @emptypromise @emptypromise 1 year ago She’s fasting so much and still picked up all this weight…. Probably it doesn’t work😁 1 Reply 1 reply @tam3519 @tam3519 1 year ago If she would shut up and let him talk! Geesh 2 Reply @garydownes1594 @garydownes1594 1 year ago Turtles don't eat for days. Is that autophagy inducing? Reply 1 reply @dd-dd2co @dd-dd2co 1 year ago (edited) so he's saying there's no evidence our 16 hour fast works?! damn! Reply 2 replies @tiborszatmari4200 @tiborszatmari4200 4 months ago ANGUS BARBIERI 382 NAPIG NEM EVETT SEMMIT 1 Reply @davidvavra9113 @davidvavra9113 1 year ago Intermittent fasting is my default, I have no interest in food until afternoon, breakfast bogs me down. But that's me. Reply 1 reply @massivecumshot @massivecumshot 1 year ago Autophagy or death. Seems like a difficult choice. Let's flip a coin Reply @damdon6946 @damdon6946 1 year ago so the comment section is full of people who while having different diets, fasting habits etc, all had ALL their health problems solved. how interesting. Reply @bugsfelt @bugsfelt 1 year ago The Jain community in India fasts for 14 days during the time of "Padhushan". I wonder if someone has data on that? Reply @Em0killer13 @Em0killer13 2 years ago What about dry fasting? Ramadan style? Perhaps that is the key to autophagy Reply 2 replies @warthog733 @warthog733 3 months ago Video did not answer the question.... Reply @Toooldtobefooledagain @Toooldtobefooledagain 1 year ago Watch "the science of fasting documentary" much more information given by Russian scientists. Reply @komalu2000 @komalu2000 5 months ago I understood nothing Reply @simon35795 @simon35795 1 year ago fasting is not for everyone if your liver does not work as it should it can be fatal ........ I got very sick from fasting Reply 1 reply @Michael-4 @Michael-4 2 years ago (edited) Spoiler: 'We don't know.' 2 Reply @Rackad @Rackad 3 years ago A 65s long question 1 Reply @seanautilis15 @seanautilis15 8 months ago that woman talked for 30% of the time asking a question that could have taken 15 seconds Reply @Itsonlymakebelieve @Itsonlymakebelieve 6 months ago Why does a short video conversation on Autophagy, turn into a discussion on unfortunate mice being put through high levels of fasting. Human autophagy can be analysed by humans on humans. There is no need to compare with ‘night feeding’ mice. Reply @StratsRUs @StratsRUs 10 months ago Poor meeces Reply @maxpyn8120 @maxpyn8120 1 year ago Muslim fasting is dry fasting for 12 to 16hours and that excludes sleeping time. 1 Reply @Stedemn @Stedemn 5 months ago I dont see any fat people on here saying they fasted but their glandular problem prevented them losing weight. Reply @gregorybishoo4627 @gregorybishoo4627 1 year ago could she drag out her question any longer? Reply @waynerobinson7143 @waynerobinson7143 2 years ago Autophagy starts at 36 hours fasted on water only no coffee or tea . 2 Reply @curtisrobinson9283 @curtisrobinson9283 1 year ago The key to fasting is...no food NO WATER Reply @atmanand5802 @atmanand5802 9 months ago 🥗Dhanyavaad Ji🌏Tat Tvam Asi📿Aham Brahmasmi💖🌈🌟🌕👁🌅🕉 Reply @generalshepherd457 @generalshepherd457 2 years ago She needs to fast more. Maybe cut down on the beer. May reduce the beer gut. Reply 3 replies @PaulRamen @PaulRamen 1 year ago what's with everybody in the comments of health related videos always feeling the need to share their anecdotal life story Reply 1 reply @robertbolding4182 @robertbolding4182 1 year ago they dont know, you only eat your body in starvation and that means you have bodyweight loss 40 pounds sound about right 20 percent. if you begin to see skin tags and moles shrinking I think that is proof your body is going after cells everywhere it no longer needs. i actually think the research will show the longest-lived humans those that live over 100 years will recall many 20 percent swings in weight where the good life was interrupted with times of famine. that means adding years to your life via autophagy was most likely accidental and not something you can do with will power Reply 1 reply @diaz5292 @diaz5292 1 year ago It took her way too long to ask the question. Reply @eugenb9017 @eugenb9017 3 months ago I've watched a lot of videos where the answer was: it depends. I've watched a lot of videos that were clickbait... Now this one I don't know what it is, but feels worse than clickbait. The answer was (sort of) "we don't know"... but the fact that it took 3 minutes... worse than clickbait, way worse. Reply @norahcarter9438 @norahcarter9438 8 months ago HE doesn't know. 😂 Reply @paulk5311 @paulk5311 1 year ago doing without food for half a day is not fasting imo. 1 Reply @rosealgreenwood6893 @rosealgreenwood6893 10 months ago Why would u waste time asking him about mice Reply @matthewlucas @matthewlucas 1 year ago In conclusion, he doesn't know. Reply @rodee1671 @rodee1671 10 months ago Old school folks call the 14 hour window, night time. Young assholes have to term it fasting pffft! Reply @BlahNish @BlahNish 3 months ago LET THEM SPEAK Reply @mr.miamibeach4363 @mr.miamibeach4363 1 year ago Fu*** QUACKS Reply 1 reply @edwardspeece8144 @edwardspeece8144 1 year ago Get a little D3 in there too… Reply @A_Chicago_Man @A_Chicago_Man 3 months ago So.............................. ????????????????????? Reply @spankymagee @spankymagee 5 months ago Well that was almost worthless Reply @owensigurdson7474 @owensigurdson7474 3 months ago (edited) This seems like a very redundant, basic question. Rhonda Patrick has always given me bad juju and for whatever reason q guy just can't take her seriously. For a doctor she says "I don't know" or asks questions with very fundamental answers. Kind of like an 9th grade girl asking questions in science class Reply @LoveFairyLights @LoveFairyLights 1 year ago Good thing I’m not a fasting mouse 🐭 Reply 1 reply @66gtb @66gtb 8 months ago She’s obviously eating a lot of carbs. Reply @svenrustempasic8332 @svenrustempasic8332 8 months ago This is not right. Human loss of weight in first several days of fasting can be as high as 1 kilogram per day, but no less than 0,5 kg per day. I tested it in my fasting sessions for years. Reply @Madmun357 @Madmun357 6 months ago Lady, eating within a 10 hour time-frame then "fasting" 14 hours isn't fasting at all. Reply @thepurplepanda1194 @thepurplepanda1194 8 months ago Moslems have been practicing fasting since year 500… from sunries till sunset its Ok not to eat much.. eat nutritious food only Reply @singingoldsongs @singingoldsongs 1 year ago I am sorry I watched this. I will not watch anymore, but I have found much success in fasting. Fasting while you're sleeping is not fasting. Weight loss mode is one thing and maintaining is another. OMAD is mainly to maintain not lose. But, get off the carbs(not 100 percent) above all else you are what you eat! I have constant success with 48hr fasting only water with lime juice not lemon anymore because their is something with lime that lemon dont have. Reply @humanoid144 @humanoid144 2 weeks ago I don't think she should fast while pregnant. Reply @harrisfrankou2368 @harrisfrankou2368 3 years ago Start research with the homeless. 2 Reply @USARMY3450 @USARMY3450 1 year ago This Doc needs some education Reply @samy6302 @samy6302 2 years ago Video made no sense at all 1 Reply @user-xd1xf9rp5p @user-xd1xf9rp5p 1 year ago I've seen some rats that definitely could live longer than 2-3 days without eating. Redo the study with obese rats. Reply @WildeMooney @WildeMooney 1 year ago misleading title Reply @ReidVV @ReidVV 10 months ago So the answer is unknown. Ok. Reply @wanderingknight10 @wanderingknight10 1 year ago All BS to the side..While in college I study anthropology an there was a nation of people who ate right before they went to bed but they fasted during their waking hours..they also had timed sleeping intervals Reply @Alex-ry6cd @Alex-ry6cd 1 year ago The body uses autophagy when on a calorie deficit. You get all the benefits of autophagy this way without the need to fast. It depends on your goals. Some cancers also spread quicker with autophagy. So, speak with an expert and don't get your nutrition advice from people with an agenda. Like this channel. 1 Reply @bobx1034 @bobx1034 1 year ago she likes to ask and then attempt to answer her own questions-- she needs to learn, ask a concise question and then be quiet and let guest answer-- looks like she isn't really "listening", but just waiting her turn to talk again. Reply @MrGusno @MrGusno 6 months ago (edited) My Prophet Muhammad (pbuh) says "shumuu tashihhu", get fasting and become healthy, said it 1400 years ago. And muslim doing fasting for 1 month during Ramadhan Reply @panduram69 @panduram69 1 year ago Quick Answer: They don't know 2 Reply @Tyrel777 @Tyrel777 1 year ago The real question, is Joe the dad? Reply 1 reply @tabletdoodlewithtomtdt6679 @tabletdoodlewithtomtdt6679 1 year ago She says 48 hours is 4 days. Why do we allow women to exercise médecine ????? Reply @dakotahstr @dakotahstr 4 months ago Dr. Mindy Peltz has knowledge on this. This guy is off, to me Reply @clairmoreau8254 @clairmoreau8254 1 year ago So no answer at all to the question then! Waste of 3 mins! Reply @SabbathSOG @SabbathSOG 3 months ago Why do you ask a question then keep talking? Reply @IamMonikaDLC @IamMonikaDLC 3 years ago Hmmm, the female is clearly pregnant. Is our beliefs in pregnancy and over-consumption correct? Should pregnant women be fasting at all? Reply 1 reply @MyChannel-ex9wq @MyChannel-ex9wq 2 years ago CLICK BAIT THERE IS NO ANSWER. Reply @carlospretel4630 @carlospretel4630 11 months ago This video is too old and that Dr. is really out of date. New research and new data has shown the benefits of intermittent fasting. Autophagy begins after 16 hours of fasting but no fast should pass the 72 hours. After that time the negatives effects of fasting surpass the positives ones. Reply 1 reply @backyardbreeze112 @backyardbreeze112 1 year ago Why do this on mice? I'm sure you can get actual people to volunteer for this. No need to torture mice.... 2 Reply @keithj6251 @keithj6251 4 years ago What is autophagy 'in the liver'? Reply 2 replies @davidcoomber4050 @davidcoomber4050 11 months ago 60% of the world are starving , look how healthy they are , fasting is good for those never hangry Reply @ashraf2661 @ashraf2661 2 months ago This is NOT fasting, but more like starvation !! Reply @raghknarrscott1790 @raghknarrscott1790 9 months ago OMAD/EOD Beef Bacon Butter & Eggs Water Tea BP Coffee Walk Bicycle Swim Sleep Repeat LIVE LONG & PROSPER 🖖 Reply @VegFacts @VegFacts 3 months ago you shouldn´t fast when you are pregnand. Reply @sigalsmadar4547 @sigalsmadar4547 1 year ago Deciding human autophagy by rodents. 🤦🏼‍♀️🤦🏼‍♀️🤦🏼‍♀️🤦🏼‍♀️🤦🏼‍♀️🤦🏼‍♀️ Oy vey Reply @munichbier1167 @munichbier1167 1 year ago Ask the question and then stop talking! Reply @Trevor-Official @Trevor-Official 3 months ago this information is incorrect. autophagy begins in humans around the 72 hour or 3 day mark. intermittent fasting helps with sleep, but that's about it. Reply @Chrisbell804 @Chrisbell804 10 months ago Pointless info Reply @jddr555 @jddr555 1 year ago Poor mice, starving them. The tiny metabolisms cannot go so long without food. Animal abusers!! And one more thing ... WE ARE NOT MICE! 1 Reply @hafeezrehman3489 @hafeezrehman3489 1 year ago (edited) Muslims fast for a month every year ,,RAMZAN, A gift by God,. Also there is advise to 3 days every month on 13,14 and 15th of Moon days,, Please research advantages of these Reply @johnyg78 @johnyg78 3 months ago Well that was a waste of time 1 Reply @faridsaid9180 @faridsaid9180 2 years ago Ramadan is the 100% accuracy of Autophagy Reply 3 replies @karenrader2160 @karenrader2160 1 year ago This video tells us basically nothing. Reply @lchris5709 @lchris5709 3 months ago You obviously haven't reached it. Reply 1 reply @inqrotv @inqrotv 11 months ago What a long question Obviously I quit the video Reply @donwinston @donwinston 6 months ago Silly. Do some regular exercise. Way way better than fasting. Reply @ginafromcologne9281 @ginafromcologne9281 2 years ago That German guy speaks English with a horrible accent, can you give him subtitles, please? Reply 3 replies @6800Alex @6800Alex 6 months ago Good grief, shut up and let him answer. Reply @Myrslokstok @Myrslokstok 1 year ago Starving and walking are the only things humans are any good at. 1 Reply 1 reply @eppystein2953 @eppystein2953 3 years ago 6 to 20 days. None of this bs 48 hour nonsense. 2 Reply 2 replies @neversayjello @neversayjello 3 years ago forgot to mention autophagy results in diarrhea 2 Reply 3 replies @saidhafez7517 @saidhafez7517 10 months ago Muslims people are fasting for 16 hours for 30 days in Ramadan every year so cancer not too much in Islamic countries 😊😊 Reply @rachelkarengreen99 @rachelkarengreen99 1 year ago GUYS FASTING WORKS!! I fasted for 100 days straight, no food or water, and I gained 35 pounds of lean muscle and went from 30% to 7% body fat. I also gained insane pheromones' and now have 2 girlfriends and 3 boyfriends. 2 Reply 1 reply @alejandrop.s.3942 @alejandrop.s.3942 9 months ago Homeless people are the most healthy then. 1 Reply @5050kas @5050kas 1 year ago not helpful Reply @bathulasrikanth2256 @bathulasrikanth2256 8 months ago How silly ...🤣 People invested billions of dollars for many years to find that fasting is the best and only way to clean your whole body from cellular levels,and they found that humans food is not Meat, vegetarian food only suitable for human body that nature gives. They saying that "we found a new thing"😂😂. Fact is they didn't found them, They actually exists in nature We actually went far from nature by eating wrong food like meat and others. But in India Lakhs of years ago in Vedas writtend like "Lankhanam Parama Aushadham". Lankhnam=fasting Parama=Supreme Aushadham=Medicine. and still people follow this in the name of god or with spiritual practices. So Even Tons of Tones of Noble Prizes also not compete to Vedas knowledge. Jai Hind Jai Bharat 🙏🙏 "World is one Family" says in Vedas. Reply @strictnonconformist7369 @strictnonconformist7369 1 year ago Why do we care about rats/mice and autophagy? We care about humans ;) 1 Reply @user-il1nx9bl9z @user-il1nx9bl9z 3 months ago He’s creepy Reply @Skywalker-zs9tf @Skywalker-zs9tf 6 months ago (edited) I bet he's not a doctor! He can't pronounce "circadian" for god's sake! He clumsily calls it "circumdian", and there is no such word! Reply @jackwilliamatkins5602 @jackwilliamatkins5602 9 months ago You’re 12 months behind Jesus Christ. Reply @richforever6231 @richforever6231 9 months ago I don’t like the way this guy talks 1 Reply @KHAOUI-SAMA @KHAOUI-SAMA 1 year ago Fasting is found in Islam and its duration is 30 days out of every year. Look for its benefits and may God guide you to the religion of truth Reply @feralkat9370 @feralkat9370 11 months ago THIS WOMAN TALKS TOO MUCH AND INTERRUPTS HER GUESTS! Typical American 'host'! Lol Reply @coked-upcat924 @coked-upcat924 1 year ago Autophagy is always happening, I hate when people say "activate autophagy" or "cause autophagy". Reply @RichardPeterShon @RichardPeterShon 1 year ago Read the Bible. It tells you how to live a healthy life. 1 Reply 1 reply @mohsinabrar1015 @mohsinabrar1015 1 year ago We muslims fast for 30days in a year 14 16 hours a day Reply @eddiediesel9035 @eddiediesel9035 7 months ago I get angry when the talk about testing on animals, mice rats whatever. STOP ABUSING ANIMALS !!! Reply 1 reply @uncleluncai4208 @uncleluncai4208 2 years ago Science & Sign are two different thing in Quran. U have a very good brain, knowlegde & mind, but U don't know about existing of the Most Creator. ALLAH All The Mighty. But you deny it, and say it found by science. Science can't count when date human die. All muslim fasting along time ago. Islam is built on five things: the testimony that no god deserves to be worshiped except Allah and Muhammad is the messenger of Allah, establishing prayer, paying zakat, going hajj, and fasting in the month of Ramadan Reply 1 reply @rogerhallau5284 @rogerhallau5284 4 months ago That woman is irritating she goes on and on and drags out her questions Does coffee induce autophagy? | Guido Kroemer FoundMyFitness Clips 87.1K subscribers 13K views 4 years ago #autophagy #aging #cancer Coffee consumption is associated with protection from several chronic diseases, including cancer, cardiovascular disease, and neurodegenerative disease. Some of the beneficial effects of coffee may stem from its ability to induce autophagy. In a study in which fasting mice were provided either caffeinated or decaffeinated coffee in drinking water, autophagy was observed in the liver, muscle, and heart just four hours after consumption. In this clip, Dr. Guido Kroemer discusses the autophagy- inducing qualities of coffee. … 15 Comments rongmaw lin Add a comment... 4 years ago Watch the full episode: https://www.youtube.com/watch?v=Gm626MgpveI FoundMyFitness episode page: https://www.foundmyfitness.com/episodes/guido-kroemer More clips from this guest: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gJJa4R_-vlojMyq0GJK6xkn 4 Reply FoundMyFitness Clips · 3 replies @JunoBeach1944 @JunoBeach1944 4 years ago Finally, a vice of mine that has a longevity benefit. 13 Reply 1 reply @_jamesbradley__ @_jamesbradley__ 4 years ago Another great vid, thanks Dr. Patrick😎👍 3 Reply @d2row96 @d2row96 4 years ago Love coffee! 1 Reply @user-wf5zt2lf6v @user-wf5zt2lf6v 10 days ago Coffee with sugar or without Reply @gusti2wire @gusti2wire 4 years ago so even decaffeinated coffee induced the autophagy? Increasing general autophagy as a treatment for neurodegenerative diseases like Parkinson's Disease FoundMyFitness Clips 87.1K subscribers Subscribe 131 Share Download Clip Save 6,606 views Apr 14, 2019 #autophagy #aging #cancer Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are characterized by protein aggregation and mitochondrial dysfunction, due in part to mitophagy failure. An emerging strategy in the prevention and (possibly) treatment of neurodegenerative diseases is starving cells as a means to induce general autophagy to help rid the cell of protein aggregates. In this clip, Dr. Guido Kroemer describes how mitophagy contributes to the pathophysiology of neurodegenerative disease and how autophagy might mitigate these processes. This clip was taken from the FoundMyFitness interview with Dr. Guido Kroemer found at • Dr. Guido Kroemer on Autophagy, Calor... Also see related clip on mitophagy: • Mitophagy: a signal for mitochondrial... Original episode published on July 31, 2017 ⏳ #aging #autophagy #cancer 🧫 Transcript Follow along using the transcript. Show transcript FoundMyFitness Clips 87.1K subscribers Videos About FoundMyFitness Clips 87.1K subscribers 1:05:44 Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation by FoundMyFitness 349K views · 6 years ago 12 Comments rongmaw lin Add a comment... @FoundMyFitnessClips Pinned by FoundMyFitness Clips @FoundMyFitnessClips 4 years ago Watch the full episode: https://www.youtube.com/watch?v=Gm626MgpveI&t=6s FoundMyFitness episode page: https://www.foundmyfitness.com/episodes/guido-kroemer More clips from this guest: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gJJa4R_-vlojMyq0GJK6xkn 3 Reply @_jamesbradley__ @_jamesbradley__ 4 years ago I love the small short clips. Solid info. Thank so much! 😎👍 7 FoundMyFitness Clips Reply FoundMyFitness Clips · 2 replies @elizabethduhon3038 @elizabethduhon3038 7 months ago Thank you so much Reply @okomojelepo @okomojelepo 4 years ago Is verapamil ok?! Reply @lennyaaron9899 @lennyaaron9899 2 years ago At this point i'm still very shocked with the negative result I got after suffering from genital herpes for so long. Thanks once again Dr.ademise for your medication 1 Reply @JamesBrown-hs6vg @JamesBrown-hs6vg 2 years ago Fasting increases BDNF production. Can BDNF regenerate dopaminergic neurons? 1 Reply 1 reply