Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more

9+ Avatar image 2:12:44 / 3:01:28 • Joan Mannick’s studies of RTB101 & other ATP-competitive inhibitors of mTOR 272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more Peter Attia MD 549K subscribers Subscribe 1.1K Share Download Clip Save 75,298 views Sep 25, 2023 The Peter Attia Drive Podcast Watch the full episode & view show notes here: https://bit.ly/3PrxgPt Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Peter welcomes guests David Sabatini & Matt Kaeberlein, two world-leading experts on rapamycin & mTOR. David & Matt begin by telling the fascinating story of the discovery of rapamycin & its brief history as a pharmacological agent in humans. They then unravel the function of mTOR, a central regulator of numerous biological processes, & they discuss the pathways through which rapamycin exerts its potential benefits on lifespan. They touch upon initial studies that suggested rapamycin may have geroprotective effects & the ongoing research that continues to shed light on this unique molecule. Furthermore, they discuss the elusive details surrounding the frequency & dosing of rapamycin use in humans, & Peter emphasizes his reservations about indiscriminately prescribing rapamycin as a longevity drug for patients. We discuss: 0:00:00-Intro 0:01:00-David & Matt’s expertise in mTOR & rapamycin 0:12:00-The discovery of rapamycin & first use in humans as an immunosuppressant 0:19:05-Emergence of rapamycin as a molecule with the potential to prolong lifespan 0:25:53-Groundbreaking rapamycin study on mouse lifespan extension & the open questions about the timing & frequency of dosing 0:36:26-Explaining mTOR & the biology behind rapamycin’s effects 0:47:13-Differences in how rapamycin inhibits mTOR complex 1 (MTORC1) versus mTOR complex 2 (MTORC2) 0:51:20-Reconciling the biochemical mechanism of rapamycin with its longevity benefit 0:56:42-Important discoveries about the interplay of amino acids (leucine in particular) & mTOR 1:04:43-Reconciling rapamycin-mediated mTOR inhibition with mTOR's significance in building & maintaining muscle 1:12:00-Unanswered questions around the tissue specificity of rapamycin 1:18:09-Rapamycin’s ability to cross the blood-brain barrier & its potential impacts on brain health & neurodegeneration 1:26:40-Rapamycin may act as an immune modulator in addition to immunosuppressive effects 1:40:41-Might rapamycin induce changes in T cell methylation patterns, potentially reversing biological aging? 1:49:00-Rapamycin side effects & impacts on mental health: fascinating results of Matt’s survey on off-label rapamycin use 1:59:32-Impact of taking rapamycin in people who contracted COVID-19: more insights from Matt’s survey 2:05:20-What David would like to study with mTOR inhibitors 2:09:50-Joan Mannick’s studies of RTB101 & other ATP-competitive inhibitors of mTOR 2:20:10-Impact of mTOR inhibition on autophagy & inflammation & a discussion of biomarkers 2:28:24-The Dog Aging Project: what we’ve learned from testing rapamycin in dogs 2:36:20-Preliminary results of primate studies with rapamycin 2:39:31-Dosing of rapamycin 2:49:33-Effect of rapamycin on fertility 2:55:30-Outlook for future research of rapamycin & the development of rapalogs -------- About: The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, & all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, & more. Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan & simultaneously improving their healthspan. Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only & does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information & the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, & they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures & the companies I invest in or advise, please visit my website where I keep an up-to-date & active list of such companies. For a full list of our registered & unregistered trademarks, trade names, & service marks, please review our Terms of Use: https://peterattiamd.com/terms-of-use/ Chapters View all Explore the podcast 258 episodes The Peter Attia Drive Podcast Peter Attia MD Podcasts Transcript Follow along using the transcript. Show transcript Peter Attia MD 549K subscribers Videos About 145 Comments rongmaw lin Add a comment... @PeterAttiaMD Pinned by Peter Attia MD @PeterAttiaMD 3 months ago In this video, we discuss: 0:01:00-David & Matt’s expertise in mTOR & rapamycin 0:12:00-The discovery of rapamycin & first use in humans as an immunosuppressant 0:19:05-Emergence of rapamycin as a molecule with the potential to prolong lifespan 0:25:53-Groundbreaking rapamycin study on mouse lifespan extension & the open questions about the timing & frequency of dosing 0:36:26-Explaining mTOR & the biology behind rapamycin’s effects 0:47:13-Differences in how rapamycin inhibits mTOR complex 1 (MTORC1) versus mTOR complex 2 (MTORC2) 0:51:20-Reconciling the biochemical mechanism of rapamycin with its longevity benefit 0:56:42-Important discoveries about the interplay of amino acids (leucine in particular) & mTOR 1:04:43-Reconciling rapamycin-mediated mTOR inhibition with mTOR's significance in building & maintaining muscle 1:12:00-Unanswered questions around the tissue specificity of rapamycin 1:18:09-Rapamycin’s ability to cross the blood-brain barrier & its potential impacts on brain health & neurodegeneration 1:26:40-Rapamycin may act as an immune modulator in addition to immunosuppressive effects 1:40:41-Might rapamycin induce changes in T cell methylation patterns, potentially reversing biological aging? 1:49:00-Rapamycin side effects & impacts on mental health: fascinating results of Matt’s survey on off-label rapamycin use 1:59:32-Impact of taking rapamycin in people who contracted COVID-19: more insights from Matt’s survey 2:05:20-What David would like to study with mTOR inhibitors 2:09:50-Joan Mannick’s studies of RTB101 & other ATP-competitive inhibitors of mTOR 2:20:10-Impact of mTOR inhibition on autophagy & inflammation & a discussion of biomarkers 2:28:24-The Dog Aging Project: what we’ve learned from testing rapamycin in dogs 2:36:20-Preliminary results of primate studies with rapamycin 2:39:31-Dosing of rapamycin 2:49:33-Effect of rapamycin on fertility 2:55:30-Outlook for future research of rapamycin & the development of rapalogs 15 Reply 4 replies @raiderkeno @raiderkeno 3 months ago Peter really reinforced something that I always believed in. I have been exercising religiously since I was a teenager, all strength training and cardio. I am 50 now. I have made a lot of bad choices along the way but the one thing that I never did, was stop training. It made me really excited about all the other pieces of the puzzle. I’m working hard on zone 2 training and loving the progress. 💪🏼 11 Reply 1 reply @YasminA-jm9zs @YasminA-jm9zs 3 months ago Besides the great information, the video format and audio quality are amazing! It’s hard to achieve when everyone is in separate parts of the world but you all did it. Thank you!! 16 Reply @cannamail7570 @cannamail7570 3 months ago This was awesome! You asked the questions that were on my mind lately. The timing of this is amazing. Keep up the long detailed format... the deeper the better. 9 Reply 1 reply @settleinwithsylvie @settleinwithsylvie 3 months ago My son has been on it (Sirolimus) for 6 years for a genetic immune deficiency thanks to the NIH and it has changed his life! He is now in law school and doing so well - where before his condition was steadily declining and he had lung disease on top of everything else. It has completely reversed his lung disease and put his disease into a remission of sorts. Miracle drug! 23 Reply 2 replies @bob-ss4wx @bob-ss4wx 3 months ago Great having Matt Kaeberlein. Matt is the real deal in anti-aging. Can't wait to see what he comes up with with his new company. 6 Reply @davidmoran7827 @davidmoran7827 3 months ago What a fascinating podcast as I've been very interested in learning more about Rapamycin. I really need some slides though to make it easier for me to understand the science. 😁 6 Reply @bob-ss4wx @bob-ss4wx 3 months ago Really great to see David Sabatini where he belongs; helping humanity! 6 Reply @JohnSlack89 @JohnSlack89 3 months ago I didn't hear an explicit discussion around the effect of the adaptive immune system vs. the innate immune system. I loved the suggestion to frame the question more broadly: "how is rapamycin improving the immune system?" rather than specifically around methylation. Could it have something to do with how the adaptive immune system works from the top down? (like the thymus being affected?) that'd also be supported by a reduction in inflammation. As the adaptive immune system declines, the innate immune system would have to ramp up, and it just blasts things more indiscriminately with inflammation, right? Could it be that rapamycin modulate adaptive vs innate immune function? 5 Reply @anthroscope8657 @anthroscope8657 3 months ago (edited) Tremendous work. Crucial question: what is the implication of what David is saying about R's side effects (ulceration-sores/epithelium) when it comes to autoimmune disease of the GI tract (IBD). It seems that Rapamycin may be effecting 2 opposite directions re: GI autoimmunity. 1.(beneficial) modulating the immune system. 2 causing epithelial breakdown and some ulceration? Any sense of the effect of this on IBD and what prevails? 3 Reply @rapamycinnews @rapamycinnews 3 months ago Fantastic discussion! Should be required listening for anyone interested in longevity using rapamycin, or who is already taking rapamycin for longevity. 2 Reply @allehelgen @allehelgen 3 months ago Hands down the best panel of experts. 4 Reply @zenrand688 @zenrand688 2 months ago Great video and thanks so much for taking the time to go into so much depth on this subject matter. You mentioned reversing ovary atrophying but I’ve not seen any mention of whether Rapamycin helps reverse Thymic involution. I would think this would be of significant interest? Reply @bob-ss4wx @bob-ss4wx 3 months ago one of your best podcast ever! Thank you. 4 Reply @karlpk3907 @karlpk3907 3 months ago Kudos to Peter for having the "cancelled" David Sabatini on his podcast, who in my view is one of the great scientists on the planet, and who should eventually win a Nobel prize, but probably won't. for all the obvious and tiresome reasons. 40 Reply 6 replies @user-sx4kv3hx9d @user-sx4kv3hx9d 3 months ago Thank you for the podcast Dr Attia. You are clearly the most ethical Dr on the internet, nowadays when most Doctors online are trying to sell you something. Your position on that matter was very clear, you don't feel comfortable to promote or sell anything as a doctor even if you believe in that product, for the simple reason that it will interfere with your ethical values as a Dr. You took a noble step giving up a lot $$ where the majority of doctors including your colleagues fail. This indicates your ethics as a doctor but first and foremost as person. Respect for that! 4 Reply 2 replies @belindaratcliffe6673 @belindaratcliffe6673 3 months ago P.S. Thank you for doing this show and thank you for the information! You are the best! 1 Reply @JuliMoodyStunts @JuliMoodyStunts 3 months ago OUTSTANDING VIDEO ❤ SO MUCH WE DON'T KNOW AND NOT A BIG CONCERN TO LEARN UNLESS THERE IS GREEDINESS BEHIND IT . I WOULD LOVE TO VOLUNTEER FOR THE TRIALS AS AN ATHLETE . Thank you for bringing great videos and information 1 Reply @juhamartikainen3050 @juhamartikainen3050 3 months ago Hope that as many people as possible would hear this quality discussion. 1 Reply @Equinox601 @Equinox601 3 months ago I think this would have benefited from a bit more background on metabolism. Glycolysis vs FAO. Maybe next time you can talk about these topics as well as AMPK and the paradigm of mTOR regulation of T cell metabolic state as canonical example? 2 Reply @ritafares3419 @ritafares3419 3 months ago mind boggling podcast, always with Attia, I love it, i feel so smart listening to you as I can understand eveything of what is being talked about and I'm very far from the medical field 1 Reply @JoseChung21 @JoseChung21 3 months ago Use your platform to get these studies done please! 2 Reply @SilverFan21k @SilverFan21k 2 months ago Ty Peter for covering Longevity ❤ 1 Reply @SirGalaEd @SirGalaEd 3 months ago Veterinary professional here. You have my attention on 2 levels 3 Reply @belindaratcliffe6673 @belindaratcliffe6673 3 months ago I have been thinking about taking this to help calm down my immune system, I might have RA and am doing well to control whatever the hell is going on by diet, and NMN & resveratrol have helped a lot. I hope that it will just reset or calm down my immune system enough that it causes it to go into remission. The pain in my joints as soon as I eat beef or sugary or refined. I love beef! I am South African and man I miss biltong a lot! If this stuff could help me get to a point where I can eat a tiny bit of bilton, I would be VERY happy! The reason I want to try rapamycin is because I have been given prednisone once before and I had a very bad reaction to it and I had 2 years of heartburn non-stop. It made me feel like I was going to die and so I do not want to take it ever again. If all goes well or even if it fails, I will come back and let you know what my experience is. 2 Reply 2 replies @learningforthelonghaul @learningforthelonghaul 3 months ago Amazing discussion. Thank you for sharing Reply @tonynesta3577 @tonynesta3577 3 months ago (edited) 65 yr old man here, no major medical problems. I've been taking Rapamycin for almost a year, 1mg a week. I tried 2 mg a wk but I felt it was "too much" for my body. I'm getting it online but I think I need to get it from my doctor, but he won't "just prescribe it." Feeling pretty good with more energy, for about 3 days, no major side effects except minor mouth sores again for about 3 days. I do hydrogen peroxide with my tooth brushing and that helps. Im also interested in some kind of clinical study. Yes, expensive $12.USD a pill online. Great discussion.😮 8 Reply 1 reply @sentient_strong_spiritual @sentient_strong_spiritual 2 months ago Thank you, dr. Attia. You are great. Reply @Candleflower42 @Candleflower42 3 months ago (edited) I heard a former MD recovered from “chronic fatigue” using rapamycin. I suppose this audience is mostly healthy but if any of you know anything about this or of any others who have recovered from ongoing fatigue using this, would you please comment? Thanks. 2 Reply @westfield90 @westfield90 2 months ago Sadly I don’t think the required clinical trials will ever take place in our nation since there just isn’t enough of an incentive for anyone to fund them. Hopefully some group in China, India or Japan can conduct the trial and we can finally see if it helps humans Reply @vladimirlarosa9584 @vladimirlarosa9584 3 months ago (edited) Muy buena discusión! Muchas Gracias !!! Reply @kweirmeir @kweirmeir 2 months ago Interesting that Sabbatini doesn't take it. I'm ordering whatever I can find from India based on what you guys are saying, and willing to accept that it might be 20% flour. Reply @Irondukesteve @Irondukesteve 3 months ago Great video to all 3 of you. 👍👍 3 Reply @madison1446 @madison1446 3 months ago Mouth Sores: you had mentioned Arginine earlier; a higher Arginine:Lysine ratio might encourage some mouth virus sores😊 1 Reply 2 replies @MichaelMerritt @MichaelMerritt 3 months ago Bryan Johnson of the popularized blueprint protocol is a good n of 1 study that you can definitely build muscle while on a biweekly 13mg rapamycin protocol and moderate caloric deficit (1:07:35) 1 Reply @billytheweasel @billytheweasel 3 months ago Always smart, useful, and mind blowing too. Reply @janicemims9799 @janicemims9799 3 months ago (edited) Wasn’t one of rapamycin’s early noted actions a very effective treatment for toenail fungus? I know that in the grand scheme, control of toenail fungus is pretty small. However, for sufferers who have not had success with other treatments (Rx or OTC) this is a pretty big deal. Thoughts? 8 Reply 1 reply @MichaelMerritt @MichaelMerritt 3 months ago Incredible interview, thank you! Reply @evanclemens8968 @evanclemens8968 1 month ago Organ transplant pharmacist here - sirolimus is still routinely used in several subpopulations for example liver transplant patients with h/o hepatocellular carcinoma and heart transplant patients with cardiac allograft vasculopathy Reply @bob-ss4wx @bob-ss4wx 3 months ago You mentioned L-Arginine. what role does that play? similar to leucine? 3 Reply @hamidaabdenour9092 @hamidaabdenour9092 3 months ago I was waiting for this episode ❤ Reply @andrewboss2018 @andrewboss2018 4 weeks ago The discussion on dosing is sobering concerning the current human dosages in longevity circles. 2:39:31-Dosing of rapamycin Reply @donnavondenbosch8413 @donnavondenbosch8413 3 months ago I had a brain aneurysm bleed, off the circle of Willis , due to a bleed, I was put on a breathing. They but a pin in my head. I am 66. I feel better than I ever did. I had to take anti-rejection drugs, 1 Reply @gstlynx @gstlynx 3 months ago Fascinating. Thanks Docs. Reply @sandragee2864 @sandragee2864 3 months ago (edited) As I’m listening to this podcast, I surfed over to Wikipedia to read about rapamycin. I saw references to sex differences in the anti-aging effects of rapamycin use in latter aged female versus male mice and that there seemed to be anti-aging benefits in males, but not in females. Granted, I haven’t surfed over to the 2 references Wikipedia listed for this statement. Still, I think it worthwhile to mention because I want to hear from y’all what your response is. 2 Reply 5 replies @madison1446 @madison1446 3 months ago What about sarcopenia and muscle health in older dogs on rapamycin? 2 Reply @charlesamrhein1292 @charlesamrhein1292 3 months ago Hi Folks, about rapamycin, John Krystal (one of the original Ketamine New Haven group and a co-author on the rapa/ket study) said that because Ketamine activates mTOR, they expected a block of the antidepressant effect. However the result was the opposite of what theoretical knowledge would predict, a potentiated antidepressant effect, and a more enduring one (up to two weeks). So your questions about mechanism are spot on, but this is a great example of why theoretical knowledge of mechanisms does not mean you can predict outcomes, this remains an empirical question. Oh, also, the rapa was administered two hours before the ketamine infusion (two hours to peak blood levels was the thought), and has a much longer half-life, so timing is also an open question requiring empirical answers. So maybe rapa could be administered a day or two before the ketamine administration, or get different outcomes with how this is timed, or maybe even block the rapamycin effects. Very interesting. There is a youtube podcast where Tim Ferriss interviews Krystal about this study. 1 Reply @andreacrouch36 @andreacrouch36 3 months ago Heck yes. So excited. Thanks so much! Reply @pwcoon @pwcoon 3 months ago These two guests need to be introduced to ARROGANTS because they have NONE!!! AND THEY SHOULD!!! The population is so fortunate to have people like this in the world!!! 2 Reply @lisakaner.n.9637 @lisakaner.n.9637 3 months ago could the mouth (GI?) sores be remediated by Ozone tx? 1 Reply @MichaelMerritt @MichaelMerritt 3 months ago Does taking Lysine help prevent the cold sores? and would that impact the effects of rapa in some way? Reply 1 reply @5kribbles @5kribbles 2 months ago Why doesn't Attia just start crowd funding, or go to his Silicone valley friends? He keeps saying how interesting and important and relatively cheap these studies are. He has a huge platform and is himself a millionaire. DO SOMETHING! 3 Reply 1 reply @joannepizel2728 @joannepizel2728 3 months ago I love The Drive but I'm going to skip this one as my FOMO is already too high when it comes to Rapamycin. My Dr says she can't even get access to it in Singapore.😭 1 Reply @westfield90 @westfield90 3 months ago I have a stupid question but where does the body get all these raw materials such the ribose sugars and dna bases from? All the materials to form proteins for the hundreds of enzymes and other functional proteins that are happening all day long? How much of a meal provides the body with all of these raw materials? Suppose I ate Doritos every day for a month would the body’s processes come to a standstill since I’m not providing protein and the other nutrients? 1 Reply 1 reply @SteveHazel @SteveHazel 3 months ago my favorite topic :) Reply @zack_120 @zack_120 3 months ago David's house analog makes lots of sense which directly points to the direction of manipulating the power plant, mitochondria. 1 Reply @Seanbrickss @Seanbrickss 3 months ago Building a memorial home for my late dad was a challenge, but with a guaranteed $37,000 weekly returns from trade I have been able to raise enough for the sick old ones in our neighborhood 6 Reply 21 replies @RMHCS-the-return @RMHCS-the-return 3 months ago Need to get it approved for Cowden Syndrome. ATM we have to buy it from India Reply @natalieaxl804 @natalieaxl804 3 months ago Thank you 🙏 Reply @jobyyboj @jobyyboj 3 months ago The marmoset trial published no effect on epigenome. "DNA methylation age analysis of rapamycin in common marmosets". Reply @madison1446 @madison1446 3 months ago Thank you! Thank you! Thank you!😊 Reply @user-on5iy1ee3u @user-on5iy1ee3u 3 months ago New member and subscriber here. Great topic but too little in the clinical benefits, known or speculated, and too much on the details of lab data on the details of mechanism. Reply 1 reply @bob-ss4wx @bob-ss4wx 3 months ago and of course Thank you Peter. Reply @bob-ss4wx @bob-ss4wx 3 months ago has anyone done a is there any studies of transplant people who are taking daily and larger doses of rapamycin? Reply @hulken1988 @hulken1988 3 months ago Can you make an episode about kids with autism? Everything from food, behaveral tools, sauna, supplements and more? Reply @thaidomain @thaidomain 3 months ago My observational ‘study’ indicates that rapamycin creates long-windedness and reiterations. Please provide some synthetic comments. 1 Reply @tomlyman948 @tomlyman948 3 months ago Sirolimus cost less than 2.00 mg at Mark Cuban Cost Plus 3 Reply 2 replies @generaltso9402 @generaltso9402 3 months ago So I'll be able to buy some Rapamycin when? Reply 1 reply @laurentiurudeanu4102 @laurentiurudeanu4102 1 month ago Not a word on prolonged fasting with regards to mTor? Reply @spiffffffffff @spiffffffffff 2 months ago Ought to culture people for candida and see if that explains the mouth sores. 1 Reply @chickensandw1tch @chickensandw1tch 1 month ago (edited) 53:00 hey aslong as it works Indont need to get it😂 like alien tech😎 1:28:00 rapalogs, cheaper derivatives? Reply @hermes537 @hermes537 3 months ago trying really hard to keep up with this lengthy video. I wish youtube invented a miniTube so that we could watch shorter versions of videos 2 Reply 2 replies @chickensandw1tch @chickensandw1tch 1 month ago 1:56:30 ketamine😱 Reply @evelynramos445 @evelynramos445 2 months ago Running out mice, save and put outside Reply @jackskellingtron @jackskellingtron 3 weeks ago @peterattiamd, not to call you out, but why do you keep saying you wish some benevolent billionaire would fund these studies which could be as cheap as $100-200k? Don't you have the money and/or influence to make the cheaper studies happen? I've got to imagine it would not be very hard for you to raise money for a non-profit. Reply @evelynramos445 @evelynramos445 2 months ago Makes stones Reply @bacsigabe29 @bacsigabe29 2 months ago Ooh 3 way I like it Reply @user-md2et1yr3v @user-md2et1yr3v 3 months ago Whair I get in Nepal nmn sublimen Reply @CletusFeatherbottom-px6nl @CletusFeatherbottom-px6nl 3 months ago the sideeffects onthis drug are mental tho Reply 1 reply @susymay7831 @susymay7831 3 months ago (edited) Does Peter Atila take rapamycin? 1 Reply @evelynramos445 @evelynramos445 2 months ago No tuna for cats Dr. Joan Mannick — mTOR’s Role in Aging InsideTracker 8.32K subscribers Subscribe 291 Share Download Clip Save 10,631 views Feb 22, 2023 Longevity by Design During this episode of Longevity by Design, Dr. Joan Mannick explains how mTOR influences the aging process. She explains that this evolutionarily conserved protein is involved in several cellular functions in the body and acts on longevity-promoting pathways like autophagy. Dr. Mannick also discusses the connection between mTOR and the immune system, sharing her research on how low-dose mTOR inhibitors can upregulate antiviral immunity, creating an opportunity for more targeted vaccines for older adults. After extensive research on mTOR across many species, Dr. Mannick shares impressive insight into how mTOR inhibitors like rapamycin can promote longevity. Tune in to learn more about the latest research in the field. Intro: (00:00-1:20) Dr. Mannick’s background (1:20-6:52) What is mTOR → (6:53–10:15) How Rapamycin acts on mTOR → (10:16–15:17) When to treat with Rapamycin → (15:17–21:36) Dr. Mannick’s trials with rapalogs → (21:37–28:42) The future of Rapamycin → (28:42–31:02) Cautions of anti-aging therapies → (31:02–41:10) Top tip for healthspan → (41:10–41:45) Closing remarks (41:45–end) To learn more: https://hubs.li/Q01CQ86r0 — Let’s Connect! Instagram - / insidetracker Twitter - / insidetracker Facebook - / insidetracker LinkedIn- / TikTok- / insidetracker_ Pinterest- / Website - https://www.insidetracker.com/ In the Press - https://www.insidetracker.com/press-p... Chapters View all Explore the podcast 55 episodes Longevity by Design InsideTracker Podcasts Music 1 songs 1.00 Version corp-17429-RFR NeoCortex Music Transcript Follow along using the transcript. Show transcript InsideTracker 8.32K subscribers 10K views 10 months ago Longevity by Design During this episode of Longevity by Design, Dr. Joan Mannick explains how mTOR influences the aging process. She explains that this evolutionarily conserved protein is involved in several cellular functions in the body and acts on longevity-promoting pathways like autophagy. Dr. Mannick also discusses the connection between mTOR and the immune system, sharing her research on how low-dose mTOR inhibitors can upregulate antiviral immunity, creating an opportunity for more targeted vaccines for older adults. After extensive research on mTOR across many species, D … 26 Comments rongmaw lin Add a comment... @stanleysokolow @stanleysokolow 2 months ago This was a great interview. Thanks. Reply @goodphone156 @goodphone156 4 months ago It is very clear Dr Joan!! 1 Reply @betzib8021 @betzib8021 4 months ago Well my question is how do i...an old person...get the stuff? What you guys are doing is improving the lives of old ..very rich...persons....(whose lives are already pretty dmn good).... because they will be the only ones who can get it. 13 Reply 1 reply @robertloye9381 @robertloye9381 2 months ago I am on David Sinclair's protocol. How can I find out the best dosage for rapamycin used for longevity? 2 Reply @dbpook @dbpook 3 months ago (edited) She'll take her scientific caution to the grave. We are all suffering from a terminal illness which ends in certain death - no time to wait decades for endless studies, I'm going to take it. 5 Reply @cidkagenoh9181 @cidkagenoh9181 4 months ago My biggest question is how does this treatments (and future treatments) affect quality of life, what i mean is does this treatments make a 75 y.o person be active again, or does it only make someone "live longer" but still be frail and weak? 1 Reply @bobcocampo @bobcocampo 10 months ago Will taking Rapamycin speed up autophagy when Fasting? 2 Reply @bobcocampo @bobcocampo 10 months ago What is the effect of Rapamycin with diabetes and weight loss? Reply 1 reply @MoreLifePlease @MoreLifePlease 10 months ago (edited) Has anybody told Ray Kurzweil et al. to skip the supplements for the moment because of the dearth of convincing evidence for their efficacy or against their harmfulness? 😁 2 Reply @MoreLifePlease @MoreLifePlease 10 months ago I assume that rapamycin has as powerful a down-regulating effect on beneficial viruses in our systems as on destructive ones? That it acts on them in a similar way as broad spectrum antibiotics act on bacteria in our bodies? If so, that could be really bad, couldn't it? Reply InsideTracker · 2 replies @stanleysokolow @stanleysokolow 2 months ago I hate the term "healthy diet". There are so many different dietary patterns with proponents who claim that their diet is the best for everyone. People should be more specific when they speak of a healthy diet. 1 Reply @michaelmelamed9103 @michaelmelamed9103 3 months ago If you’re an inbred laboratory mouse 🐭 this information is relevant to you 😂😂😂 3 Reply @pakelly99 @pakelly99 3 months ago Oh, I got this, ::cough::, “Money”, “More money”, “Lots and Lots of money”. Reply @Acm1pt4567 @Acm1pt4567 3 months ago They did not say much. Empty podcast Reply @bobcocampo @bobcocampo 10 months ago Please experiment to prisoners in third world country like the Philippines. 1 Reply 2 replies Regulation of growth by the mTOR pathway NIH VideoCast 38.9K subscribers Subscribe 501 Share Download Clip Save 66,425 views May 21, 2013 NIH Director's Wednesday Afternoon Lectures Regulation of growth by the mTOR pathway Air date: Wednesday, March 20, 2013, 3:00:00 PM Wednesday Afternoon Lecture Series The mammalian target of rapamycin (mTOR), the target of the immunosuppressive drug rapamycin, is the central component of a nutrient- and hormone-sensitive signaling pathway that regulates cell growth and proliferation. This pathway becomes deregulated in many human cancers and plays an important role in the control of metabolism and aging. Sabatini's lab has identified two distinct mTOR-containing proteins complexes, one of which regulates growth through S6K and another that regulates cell survival through Akt. These complexes, mTORC1 and mTORC2, define both rapamycin-sensitive and insensitive branches of the mTOR pathway. New results on the regulation and functions of the mTORC1 and mTORC2 pathways will be discussed. Author: David M. Sabatini, M.D., Ph.D., MIT Runtime: 00:59:04 Permanent link: http://videocast.nih.gov/launch.asp?1... Chapters View all Featured playlist 385 videos NIH Director's Wednesday Afternoon Lectures NIH VideoCast Transcript Follow along using the transcript. Show transcript NIH VideoCast 38.9K subscribers Videos About Comments are turned off. Learn more