Autophagy Mechanism | Mitophagy

Autophagy Mechanism | Mitophagy Hussain Biology 207K subscribers Join Subscribe 1.3K Share Download Thanks Clip 78,976 views Premiered Mar 11, 2020 CSIR Part C Topics Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or dysfunctional components.[3] It allows the orderly degradation and recycling of cellular components. Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. Mitophagy promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. It is mediated by Atg32 and NIX and its regulator BNIP3 in mammals. Mitophagy is regulated by PINK1 and parkin proteins. The occurrence of mitophagy is not limited to the damaged mitochondria but also involves undamaged ones. Autophagy has roles in various cellular functions. One particular example is in yeasts, where the nutrient starvation induces a high level of autophagy. This allows unneeded proteins to be degraded and the amino acids recycled for the synthesis of proteins that are essential for survival. Featured playlist 128 videos CSIR Part C Topics Hussain Biology Transcript Follow along using the transcript. Show transcript Hussain Biology 207K subscribers Videos About 48 Comments rongmaw lin Add a comment... @kirstincook6234 @kirstincook6234 2 years ago (edited) I'm currently studying for pathology boards and your videos have been incredibly helpful. Thanks! 10 Hussain Biology Reply Hussain Biology · 1 reply @aparna9709 @aparna9709 7 months ago Best video I have watched on this topic, and the only video and explanation that has actually made me understand this topic. I profusely thank you ! Reply @ifra2468 @ifra2468 1 year ago (edited) Please make video lectures on types of autophagy... Like macro, micro, chaperone mediated Autophagy... 🙃 4 Reply Hussain Biology · 1 reply @bhushansong @bhushansong 1 month ago Thanks for the detailed explanation on this topic. Very rare. Great work sir 1 Reply Hussain Biology · 1 reply @havzaimtiaz3049 @havzaimtiaz3049 3 years ago (edited) Your videos based on current research ....and it saves a lot of time to go through the reference books 5 Hussain Biology Reply Hussain Biology · 1 reply @boyabdullah2226 @boyabdullah2226 2 years ago Assalamualaikum brother. Thank you for this. Could you please make a video about AGEs (Advance glycation end products)? I love your channel and all its content! Much love, from Brunei Reply @CarefreeRambler @CarefreeRambler 2 years ago (edited) I have no idea why I'm watching this, but sounds interesting. Keep up the good work! 2 Hussain Biology Reply @bobcocampo @bobcocampo 11 months ago (edited) Please discuss autophagy and retinopathy 1 Reply @AliBaba-hn8tv @AliBaba-hn8tv 3 years ago (edited) Your way of teaching is genius, thank you sir. 2 Reply Hussain Biology · 1 reply @robertsmyk4102 @robertsmyk4102 2 years ago (edited) Please explain how autophagy occurs in human cells when nutrition is supplied from the liver even while the person is fasting or starving. Reply @manjukkrishnan567 @manjukkrishnan567 3 years ago Sir can u make a video on gene for gene concept 1 Reply @darshikasrivastava5598 @darshikasrivastava5598 3 years ago Kind of a quick revision... is this the complete pathway including all biomolecules needed for autophagy??? 1 Reply Hussain Biology · 1 reply @angelelsa5133 @angelelsa5133 1 year ago Thank you 👍👍👍 1 Hussain Biology Reply @jerrytom3514 @jerrytom3514 2 years ago (edited) Not sure if I learned anything —- But nice job 2 Reply @ranjanghosh1732 @ranjanghosh1732 3 years ago (edited) I went through some videos made by you.. attractive videos sir.. nice 2 Reply Hussain Biology · 1 reply @RabiaHumayunKhan @RabiaHumayunKhan 10 months ago (edited) thnx a lot .cancer kay baray main bata dain in detail (cancer pathology and pathways), leukemia cancer and husky subtypes with pathways and lungcancer +subtypes and pathways. and yeh wala pathway where did you study from? Hussain Biology Reply Hussain Biology · 1 reply @shankysays @shankysays 2 years ago (edited) I was reading about water fasting and how it activates autophagy. Reply @anavictoriagonzalezcarreon252 @anavictoriagonzalezcarreon252 3 years ago (edited) I love your vids!! 2 Reply Hussain Biology · 1 reply @daulatsinghtawar5306 @daulatsinghtawar5306 3 years ago (edited) Your technic to explain in amazing 2 Reply Hussain Biology · 1 reply @swagatikasenapati9021 @swagatikasenapati9021 3 years ago (edited) always the best... 2 Reply Hussain Biology · 1 reply @mariaclaraprates7847 @mariaclaraprates7847 2 years ago (edited) thanks!!!!!! this video helped me impressed how creative God is Jesus loves you 2 Reply Hussain Biology · 1 reply @berdeski1965 @berdeski1965 2 years ago (edited) .75x playback speed slows the audio making the audio more clear... 1 Reply Hussain Biology · 1 reply @hosnearabegum6457 @hosnearabegum6457 2 years ago Muslims all over the world do fasting for a mounth in every year. They do fasting from before sun rise to sun set. From 1400 years ago Islam started the fasting. 7 Hussain Biology Reply 2 replies @mainulhaque2710 @mainulhaque2710 2 years ago (edited) Islam say "you must have do fasting" Reply Hussain Biology · 1 reply @loyal4theway159 @loyal4theway159 3 years ago Man i need to eat less and fast 2 Reply Hussain Biology · 1 reply @artofmeditationwellness4486 @artofmeditationwellness4486 3 years ago (edited) We are live right now 1 Hussain Biology Reply @TheMachtigen @TheMachtigen 10 months ago The accent kills me. Next Reply @iamrichlol @iamrichlol 2 years ago (edited) can't understand what hes saying AUTOPHAGY: Definition, Mechanism, Benefits & Role ilovepathology 153K subscribers Subscribe 1.2K Share Download Thanks Clip 46,670 views Premiered May 27, 2021 CELL INJURY and ADAPTATIONS Autophagy: Definition, mechanism, benefits & Role . In this tutorial , you will learn about the Autophagy pathway, how the pathway is initiated, why the pathway is important in human health. We will understand the applied aspects of knowing autophagy, the diseases associated with dysregulated autophagy. Thanks for watching! Please like and subscribe if you found this lesson helpful :) Subscribe for more free medical lessons for undergraduate students Sucscribe ilovepathology youtube channel at / @ilovepathologyvijaypatho Check my other videos in playlists here / ilovepathologyvijaypatho Very interesting video on apoptosis here • APOPTOSIS PART 1: Definition, Causes ... Video on necrosis here • MORPHOLOGY OF CELL INJURY: REVERSIBLE... Chapter inflammation and repair • INFLAMMATION Part 10: Systemic effect... Visit pathology made simple @ ilovepathology http://ilovepathology.com/ Follow my FB page ilovepathology / ilovepathology Follow me on twitter / vijaypatho Chapters View all Featured playlist 14 videos CELL INJURY and ADAPTATIONS ilovepathology Transcript Follow along using the transcript. Show transcript ilovepathology 153K subscribers Videos About 41 Comments rongmaw lin Add a comment... @shivalikabisht1097 @shivalikabisht1097 2 years ago (edited) Sir, your channel is amazing. Thank you for making me understand so many concepts! 4 ilovepathology Reply @MS-zs8sg @MS-zs8sg 2 years ago Finally I got to know what is autophagy. Thank you Sir for making such good video. 2 ilovepathology Reply @nptelefilms7703 @nptelefilms7703 1 year ago (edited) sir good presentation but i have a query , why autophagy plays dual role in cancer ? and how? 1 Reply @rajenyqueen4779 @rajenyqueen4779 1 year ago (edited) Amazing ,thank you very much dr. 3 ilovepathology Reply @subwaymirdif @subwaymirdif 1 year ago (edited) A good presentation but you didn't mention how to be benefitted from Autophagy or how to create cellular distress without harming the body. Whether the popular concept of fasting is beneficial or there are other methods for starting this process for cleansing of the cellular junk. 3 ilovepathology Reply @fatimatuzzahra7415 @fatimatuzzahra7415 1 year ago (edited) sir can we do Mphil and phd in pathology after BS hons in BIochemistry? ilovepathology Reply @VioletSky-vf3eq @VioletSky-vf3eq 6 months ago This video is very nice to understand about autophagy. Thank you very much!!!! 1 ilovepathology Reply @nileshgoudar2000 @nileshgoudar2000 2 years ago (edited) Thank you very much sir 👍 2 ilovepathology Reply @NukeTheEyes @NukeTheEyes 2 months ago Thank you Sir🖤 ilovepathology Reply @aishwaryyamitra9182 @aishwaryyamitra9182 1 year ago (edited) Thank you sir 🙏🏻 1 ilovepathology Reply @Simi.g @Simi.g 1 year ago (edited) thank you for explaining it so well.. 1 ilovepathology Reply ilovepathology · 2 replies @anamrasool6838 @anamrasool6838 1 year ago (edited) thankyou for making me understand it so well. 1 ilovepathology Reply @waelfadlallah8939 @waelfadlallah8939 2 years ago (edited) Looking forward to watch this video thank you very much 5 ilovepathology Reply @neerajamaradana8535 @neerajamaradana8535 2 years ago (edited) Sir make videos on cell injury, free radicals, chemokines, apoptosis 2 ilovepathology Reply ilovepathology · 2 replies @katiecarternd4498 @katiecarternd4498 1 year ago (edited) very good!!!, can i have your powerpoint? 2 ilovepathology Reply @lolo-cz3yk @lolo-cz3yk 2 years ago (edited) Finally a good video 3 ilovepathology Reply @MsAhaOho @MsAhaOho 1 year ago (edited) Can anyone let me know within how many hours autophagy gets over so that I can resume eating. Example I'm fasting 3 days straight for autophagy to kick in and after that how many more hours or days i need to continue to fast for autophagy to be over ??? Or when can I resume eating from the 5th day or 4th day or anything 3lse. Please help Reply 1 reply @sushreetaacharya9783 @sushreetaacharya9783 1 year ago (edited) Nice !! 2 ilovepathology Reply @poornimakadam1330 @poornimakadam1330 9 months ago Beautiful Vedio ❤️ 1 ilovepathology Reply @medicalknowledge7950 @medicalknowledge7950 2 years ago (edited) 👍🏽👍🏽 2 ilovepathology Reply @dananjanirathnayake5059 @dananjanirathnayake5059 2 years ago (edited) thank you very much 1 Reply @thummarongklinrod6007 @thummarongklinrod6007 2 years ago (edited) Can autophagy reduce malanin ? i see some brand of cosmetic claim 3 ilovepathology Reply 1 reply @futuredoctor3120 @futuredoctor3120 1 year ago (edited) Super 1 ilovepathology Reply @ifra2468 @ifra2468 1 year ago (edited) Wowwwwwww✨✨ ilovepathology Reply @chaos.king. @chaos.king. 1 year ago (edited) ❤️❤️ Reply @medicosonly @medicosonly 4 weeks ago Which book referred Reply @dr.vasanthakumarbhaskara2644 @dr.vasanthakumarbhaskara2644 1 year ago How is it related to fasting. Do you support it benefits through autophagy any proven protocols to evidence this fact 2 Reply @shivamgaur7752 @shivamgaur7752 8 months ago हमारे like करने पर 1k मे बादल गया 1 ilovepathology Reply ilovepathology · 1 reply @user-wf8ll3bh7r @user-wf8ll3bh7r 5 months ago lysosome ChatGPT A lysosome is a membrane-bound organelle found in the cytoplasm of eukaryotic cells. It is known as the "suicide bag" or the "digestive bag" of the cell due to its crucial role in intracellular digestion and the breakdown of various substances. Lysosomes contain a variety of hydrolytic enzymes that can break down large molecules, such as proteins, nucleic acids, lipids, and carbohydrates, into smaller components that the cell can use for energy or remove as waste products. Key features and functions of lysosomes include: Digestion: Lysosomes play a vital role in intracellular digestion by fusing with endosomes, which are vesicles that contain materials ingested by the cell through endocytosis. Through this process, lysosomes degrade and recycle cellular waste, damaged organelles, and materials taken up from the external environment. Autophagy: Lysosomes are involved in autophagy, a process that allows cells to break down and recycle their own damaged or non-functional organelles. This self-eating process helps maintain cellular health and homeostasis. Apoptosis: Lysosomes are also involved in programmed cell death (apoptosis). During apoptosis, lysosomes release their digestive enzymes into the cell, leading to the breakdown of cellular components and the eventual dismantling of the cell. pH regulation: Lysosomes maintain an acidic internal environment (pH around 4.5) due to the action of proton pumps in their membrane. This acidic pH is essential for the optimal activity of the hydrolytic enzymes within the lysosome. Lysosomal disorders or malfunction can lead to various diseases known as lysosomal storage diseases. These conditions result from the accumulation of undigested materials within the lysosomes due to enzyme deficiencies, causing cellular dysfunction and damage. Overall, lysosomes play a critical role in maintaining cellular health and function by regulating intracellular digestion, recycling cellular components, and participating in programmed cell death when necessary.