mTOR Science- Muscle Growth vs. Longevity {What Is mTOR Pathway | Balancing the mTOR and AMPK Pathways to Slow Aging [2019]} METHYLENE BLUE: Impacts Longevity By Boosting Mitochondrial Efficiency [2024]

mTOR Science- Muscle Growth vs. Longevity Thomas DeLauer 3.56M subscribers Subscribe 2.5K Share Download Thanks Clip 51,911 views Apr 23, 2020 Click Here to Subscribe: http://Bit.ly/ThomasVid My Favorite Matcha is Ujido: https://ujido.com/pages/thomas-delauer Check out Celsius HERE: http://Celsius.com This video does contain a paid partnership with brands that help to support this channel. It is because of brands like these that we are able to provide the content that we do for free. The best way that you can directly support my channel, is by supporting the brands that help make this all possible. Any product that you see on my channel is a product that I also use personally, regardless of any paid promotion. Get my Free Newsletter and Downloadable Cheatsheets (eating out, travel, etc): https://www.thomasdelauer.com/life-op... Follow More of My Daily Life on Instagram: / thomasdelauer It's important that I am honest and to say that this video does have a sponsorship from Celsius & Ujido, supporting them is a good way to support my channel! Special Thanks to my team and Nicholas Norwitz - Oxford PhD Researcher and Harvard Med Student - for working diligently on research as well! Mammalian target of rapamycin (mTOR) was named because a drug called rapamycin inhibited a protein that was then named, target of rapamycin (TOR). The “m” is because it’s in mammals (zebra fish TOR is, similarly, zTOR). mTOR is central to the opposing biological processes of growth and longevity. mTOR is thought to promote growth and decrease longevity. Basically, any process you can think of relating to muscular growth and longevity probably has some relationship to mTOR. Here are some examples: Exercise activates mTOR signaling in skeletal muscles (growth) mTOR inhibits autophagy (longevity) Insulin activates mTOR (growth) Sirtuin proteins inhibit mTOR (longevity) BCAAs activate mTOR (growth) Fasting inhibits mTOR (anti-growth and longevity) And, as precited by its pathetic name, rapamycin increases (longevity), at least in mice How exactly does mTOR impact all these processes? Well, it’s kind complicated [show image below] and there are actually two different mTOR complexes (mTOR1 and mTOR2) that have slightly different functions. So, for the sake of simplicity let’s just say this: mTOR is a kinase. This means that mTOR acts to regulate the activities of other proteins by adding a phosphate group from ATP to them. Depending on what protein it adds the phosphate to, and where on that protein it does so, is can either activate of inhibit its target and pathways downstream. The message, in its simplest form, is that mTOR activity makes you live hot (and strong) but die young. But since when is science ever simple? What annoys me is that people tend to be scared of anything that activates mTOR because they are afraid it’s going to kill them. This is problematic thinking for two reasons: (1) Biology is all about balanced cycles. You need periods of growth (anabolism) and breakdown (catabolism). If you’re all anabolism (like a body builder) you will die young. However, if you’re all catabolism, you’ll die even younger. In fact, one of the leading risk factors for death in the elderly is low muscle mass. You need a functional level of muscular power to live and thrive. No mTOR and you’d wither away. In short, you do want to activate mTOR on occasion. Just don’t overdo it. “Extremes are easy, the challenge is balance.” “ (2) The inside of your body is NOT a homogenous blob! Why do people always forget that fact? Just because you activate mTOR in once place doesn’t mean you activate it everywhere. For example, when you work out you activate mTOR in your skeletal muscle but might actually decrease mTOR activity in your brain. Thus, it’s possible, and I would argue probable (such studies can’t be done in humans without cutting into their brains), that exercise activates muscular mTOR but inhibits brain mTOR, giving you the exact organ-specific balance of activity that you want! Fasting Guides How to do Intermittent Fasting: Complete Guide: • How to do Intermittent Fasting: Compl... Complete Women's Guide to Intermittent Fasting: • Complete Women's Guide to Intermitten... Beginners Guide to Prolonged Fasting | 24-72 Hour Fasting Instructions: • Beginners Guide to Prolonged Fasting ... Fasting Guidelines: What You CAN and CANNOT Drink: • Fasting Guidelines: What You CAN and ... Intermittent Fasting over Age 40 : The Complete Guide: • Intermittent Fasting over Age 40 : Th... Keto Guides How to do a Keto Diet: The Complete Guide: • Video Keto Over Age 50 - Instructional Guide: • Keto Over Age 50 - Instructional Guide Full Beginner Keto Meal Plan: Exactly What to Eat: • Full Beginner Keto Meal Plan: Exactly... Nicholas Norwitz - Oxford PhD Researcher and Harvard Med Student: https://www.dpag.ox.ac.uk/team/nichol... Chapters View all Transcript Follow along using the transcript. Show transcript Thomas DeLauer 3.56M subscribers Videos About 18:37 How to Build Muscle with Fasting | The Ultimate Guide by Thomas DeLauer 8:55 Muscle Building | 4 Common Workout Mistakes- Thomas DeLauer by Thomas DeLauer 195 Comments rongmaw lin Add a comment... @closetcleanupcoach Pinned by Thomas DeLauer @closetcleanupcoach 3 years ago (edited) Been doing Keto and I.F. now about three years. I'm 65 and feeling better than I did twenty years ago! Love your in depth biology lessons! 63 Thomas DeLauer Reply Thomas DeLauer · 2 replies @DanielsLions13 @DanielsLions13 2 years ago (edited) Well rounded presentation. I have been looking into the relationship between mTOR and longevity (or the lack thereof). New research suggests over activation of mTOR pathways may be a key area in shorter life span. If you make another video on this subject, I will watch! 9 Reply @sandraat @sandraat 3 years ago (edited) Yes please more on the scientific part of mTOR. I think you are doing a great job explaining the science on your subjects. Please keep it coming!🤩🙏🏾 11 Reply @1yoan3 @1yoan3 3 years ago (edited) I love your videos, and the more nerdy and detailed they are, the more I'm fascinated by them. I hate just random facts thrown around like a lot of youtubers do, Thomas goes into great detail and I love that, he explains everything. 6 Reply @rmohamed786 @rmohamed786 3 years ago (edited) Wonderful explanation on how to benefit between ‘Mtor on’ and ‘Autophagy on’ cycles. I started the Ramadan fasting of 30 days where one goes for about 14 hours of dry fasting everyday. I am going to alternate between foods that promote autophagy when beginning the fast before sunrise and foods that promote Mtor activity when breaking the fast at sunset with some exercise just before that. I think this will be a great strategy to balance these two states on a daily basis. 4 Reply @olgap.2902 @olgap.2902 1 month ago Firstly, love your channel and thank you for bringing all that knowledge to us, and in a clear to understand language. Would love a more detailed video since mTOR is something I'm actively conscious of and think about (I do resistance training and alternate fasting). Anyhow, I thought mTOR gets turned on when consuming at least 2g of leucine (and with exercise you just stimulate protein synthesis and that's all, so a new thing learned here). I even count my leucine intake when, for instance, I don't want mTOR activated (but consume at least 30g of protein with each meal). So after seeing this video, I admit I am a bit lost with this mTOR thing ... Thank you in advance, and once again hugely appreciate your channel! Reply @opedromagico @opedromagico 1 year ago (edited) I love how simple you explain stuff! Thanks, Thomas! Keto carnivore here for 1 year, it saved my life. Lab tests are great, eating 1 or 2 times a day, never done fasts and did up to 135h only water, salt, mag and potassium, amazing. 2 Reply @mamabakstis6882 @mamabakstis6882 3 years ago (edited) Would love more on mtor. You keep me inspired. I’ll be 60 this year. You keep me on track. I am 135. My highest weight 210. At 5’4” My goal is 128. I only see that during CT summers. I love the outdoors Thanks for what you do. 😷 4 Reply 1 reply @bw4500 @bw4500 3 years ago (edited) I would be very interested in a more detailed breakdown of mTOR. I'm a layman (no training in health sciences) but I'm really interested in this. I'm especially interested in practical recommendations of how to build a routine that achieves the balance you're referring to. SiimLand has some videos offering sample workout/diet routines designed to achieve this but I'm looking for more sources. This video was helpful and a good primer on the topic, thanks Thomas. Reply @wszystkozajetejuz2 @wszystkozajetejuz2 3 years ago (edited) very interested in mtor and balancing muscle growth with longevity. the question i'm asking is should i maintain high protein intake all the time or should i cycle it. I'm especially interested in cycling of autophagy days/weeks (e.g. fasting, metformin) and body building days/weeks (+ high protein, bcaa intake). 13 Reply 1 reply @La_sagne @La_sagne 9 months ago finally an explanation. ive heard so much about mtor is good for muscles and strength is great for longevity because falling badly when youre over 65 has quite a high lethality rate and then i heard rapamycin inhibits mtor thats why its great for longevity and i was very confused. it sounds a lot like cortison the way you explain it. cortison is important in stressful situations like a workout and afterwards for recovery but you dont want chronically high cortison levels because that has a bunch of side effects that kill a lot of people in their 50s or 60s already 1 Reply @elliottclark8776 @elliottclark8776 1 year ago (edited) Wouldn't mind extra info on how MTOR is activated and works within the body. Love your videos, already subscribed. 2 Reply @viasha @viasha 3 years ago (edited) thank you for great info as usual and yes please do more on mTOR. Been doing keto/carnivore for just 1 year, and in better health than since 7 years old [64 now]😎 2 Reply @arthurdolle5257 @arthurdolle5257 1 year ago (edited) thanks for the info. I'm 81 and cut my fasting down to 12or 13 hours a day and worried more about avoiding sarcopenia. 2 Reply @Jagged_Ice @Jagged_Ice 3 years ago (edited) Great video. Balance fasting and growth. I've been using this approach for two years with the best results of everything I've ever tried. 4 Reply @Charnest @Charnest 3 years ago (edited) I appreciate your in-depth explanation and would love to understand this better. I've listened to Dr. Gabrielle Lyon talk about this in relationship to the importance of getting enough protein - and at regular intervals. It sort of makes sense but I'd like to understand it better because it seems like it would be a real game-changer. Thank you Thomas - as always! Reply @xubifit7660 @xubifit7660 3 years ago (edited) In a recent video, you provided a supplement blend containing Creatine, Carnitine, and L-Leucine. After watching this video I was now wondering when exactly I should take this blend (before or after a workout), and should I consume BCAA's during my workout if I am taking this blend? Thanks! 3 Reply @ryanskidmore1456 @ryanskidmore1456 3 months ago well articulated as always sir! thank you for making this info so relatable. Reply @denisegaliano6724 @denisegaliano6724 3 years ago (edited) That was one of the best explanations of mtor that I haven't heard. It is a very confusing subject to me. I would love a more in-depth explanation. Thank you so much. 3 Reply @skullbellztv5642 @skullbellztv5642 1 year ago (edited) Hey Thomas that was super helpful! Thanks for that! At the end you said “let me know if you want a more in depth breakdown.” I vote for that! Appreciate everything 1 Reply @celesteinman56 @celesteinman56 3 years ago (edited) Ooo, Thomas, great breakdown, and explanation. I get it, it clicked in my brain. Thank you for taking the time, energy and effort to calmly explain what happens in our bodies..:) Reply @ashleywilkinson3700 @ashleywilkinson3700 3 years ago (edited) I am learning so much from you and what you are saying feels confident and authoritative. I am seeing results. Thank you for sharing your evolving knowledge. Reply @vincentperry6791 @vincentperry6791 3 years ago (edited) Hell yea, this is exactly the stuff i wanna do more research on... been self expirimenting through keto IF for the past several years and i can say from a medatative perspective you can definatly feel the difference in consciousness between the two states and which one your bodys leaning more tword... what I'm super intrested in finding out is the ratio between the two to acheive ones optimal balence over the function of time... like you said its not a switch and, both processes are usually happening simultaneously one more so than the other but hypothetically if from a balanced state i spent 24hours in 100% mtor building mode, then would 24hours of 100% autophagy recycle mode restore the balance? I suppose this is an impossible question as everything is individualized and situational but don't you think it'd be cool to have some sort of device, kinda like hoe a glucometer works as to tell you which state youre in and how much so? Reply @kevinmcclure7614 @kevinmcclure7614 3 years ago (edited) More mTOR, please. Your endocrine system videos are excellent. Reply @mariomaciel4745 @mariomaciel4745 3 years ago (edited) Another GREAT video, THANK YOU for all that you do especially sharing your knowledge and expertise. I do have a question if you don't mind in regards to Intermittent Fasting......Technically speaking when can your time start after you have finished eating your last bite of the day? In others words can your fasting window start immediately after your last meal or should it start like 30 minutes later an hour later? Stupid question I know, but I'm sort of OCD and anal when it come to exact time windows for starting and ending fasting periods. Thank you for your help. Reply @ikrammaududi6205 @ikrammaududi6205 3 years ago (edited) This is even better than biology class, and for free, even with cool animation 17 Reply @xxwebgodxx @xxwebgodxx 3 years ago (edited) Great video Thomas. Can you make a video for us individuals who focus on lifting weights who are on keto but want to go on and off keto like you do while maintaining/adding muscle etc. Weight loss videos are great but big fan base of yours like myself love lifting and adding muscle ( no broscientist here ) Thanks and keep up the great videos Reply @MarydToKeto @MarydToKeto 3 years ago (edited) Awesome info! Thanks so much for sharing and all the prep work that must go into these videos Reply @fabiocpt2470 @fabiocpt2470 3 years ago (edited) These scientific reviews, explained simply and in a effective way, are very appreciated. Thanks a lot. :) Reply @benjanik6297 @benjanik6297 3 years ago (edited) Thanks. I fast a few times a month. I also started BFR training. I'm 68 and want to retain some muscle but still reap the benefits of autophagy. Reply @nelsoncosta5783 @nelsoncosta5783 1 year ago (edited) Hi Thomas! You do an amazing work, thanks for sharing. I started to take HMB after lern about mtor benefits and want to know if it substitutes the leucine intake. I take Leucine + Carnitine + Creatine after workout (💡 trick I also learned from you). Wainting for Thrive Market to start operating in Brazil 🙄 Reply @hemangpatel6239 @hemangpatel6239 2 years ago (edited) Thank you for making a video on mtor. So considering mtor is activated during weight lifting, should I always consider breaking a fast right after my workout instead of breaking a fast 6 hours later so that I can reduce the number of times mtor is being activated throughout the day? I prefer morning fasted workout and not eat anything after that and then break fast at lunch and have a dinner and so on. As I expressed my concern above, I want to reduce the number of times mtor is being activated throughout the day but at the same time want to gain more benefits by combining a better routine. Also if you can clarify if I really have to have a protein shake or meal after a workout opposed to going faster for 5-6 hours after working out. I'm a big fan of your research and clarity of the content you provide. Thank you for everything. Reply @christophertravina2684 @christophertravina2684 3 years ago (edited) Amazing content as always and you are a great speaker all the way! 2 Reply @arthurviruz1234 @arthurviruz1234 1 year ago (edited) Definitely needs to understand how to reach that balance ... would be good to have more content about mTor !! 👊🏽 Reply @KThalman @KThalman 1 year ago (edited) This is the best MTOR strategy that I've heard. While I'm vegan, I supplement with BCAA and additional Leucine before and after a workout. Reply @chiba0ginger @chiba0ginger 3 years ago (edited) more mtor-authophagy info pleaseeee!!! you explain amazing! Reply @sdotjackson8 @sdotjackson8 3 years ago (edited) I would greatly appreciate a more in depth video regarding MTOR. 1 Reply @Hat75013 @Hat75013 3 years ago (edited) Dear Thomas, I will be honored to learn more about M-Tor...your knoewledge contribute to help people around me. Sincerely, a french viewer :) Reply @megyeridavid6380 @megyeridavid6380 3 years ago (edited) How much time would it take to activet mTOR? On some videos you mention that after a breakfast a 24h fasting finished with training and bcaa+creatine+carnitine and lean protein would trigger mTOR. Would this be a 15minutes or even hours? Reply @ch3ng22 @ch3ng22 3 years ago (edited) I HOPE YOU ARE READING THIS THOMAS!!! THANK YOU FOR CHANGING MY LIFE! GOD BLESS YOU AND YOUR FAMILY 35 Thomas DeLauer Reply @cetogenicaportugal8514 @cetogenicaportugal8514 3 years ago (edited) Really would like to get further acknowledge about Mtor! Thank you for all your amazing content!!! Reply @jaybrooks6235 @jaybrooks6235 1 year ago (edited) I would love a more in depth discussion on mTOR! Reply @banko1996 @banko1996 3 years ago (edited) More mTOR videos,we want to learn more :) 3 Reply @lucys1309 @lucys1309 3 years ago (edited) I would love to hear more about mTOR. Thank you! Reply @Jj.1897 @Jj.1897 3 years ago (edited) Hey Thomas, I am confused about Tocopherol’s. Can you provide some understanding? Thanks! 1 Reply @Kristif815 @Kristif815 2 years ago (edited) Cold brew coffee with a tiny bit of heavy whipping cream and pyure sweetener is my fasting vice. I always wondered if the teaspoon of cream here and there messed up my mTOR/autophagy. There really isn't much information out there, so I appreciate these videos. Thanks Thomas! Keep them coming. Reply @conorgrace2378 @conorgrace2378 3 years ago (edited) Technical question here Thomas! After I workout and I want to spike mtor, should I remove autophagic compounds from my protein shake? I currently add raw cacao which activates sirtuins 4 Reply 2 replies @GetBuffBullys @GetBuffBullys 3 years ago (edited) Nothing but Gains here 💪🏼💪🏼💪🏼 Love the content sir def dropping bombs of knowledge 4 Reply @kimdavis7812 @kimdavis7812 3 years ago (edited) Ok 👍 so how do we ascertain our sweet spot? I do lift heavy every day... I do IF 16/8 or 18/6 & I do eat a fair amount of protein .... how do I know if all of this is too much?! 2 Reply @magnusdanielsson2749 @magnusdanielsson2749 1 year ago (edited) So should one then try and match the amount of protein to the amount of muscle mass and muscle growth one has? What would this look like in the age of "1 gram of protein per lbs for optimal growth"? Reply @sherlynpatterson4304 @sherlynpatterson4304 3 years ago (edited) Yes, please do a special video about the balance specific to prevention of cancer recurring. Reply @jackwhitehouse2569 @jackwhitehouse2569 3 years ago (edited) Thomas always love your content thank you. Give me more in mtor content please :) :) Reply @thekevorlando @thekevorlando 3 years ago (edited) Hey Thomas I have a question how much can I count on autophagy for my skin the bounce back I was seriously injured in 2018 and put on a lot of weight I mean a lot how much will my skimmer cover I'm 50 years old and currently I'm doing extended fasting and carnivore when I seed and I'd like to know where you stand on straps for working out pluses and minus thanks I do enjoy the videos Reply @McSLaughterxxx @McSLaughterxxx 3 years ago (edited) I'd love to see the more in depth video on mtor. Reply @patrickvanmeter2922 @patrickvanmeter2922 2 years ago (edited) So, you don't have to eat unless you have lifted weights? Just kidding. I wonder what percent of both would be ideal. I'm 80 and still lift but longevity at my age obviously becomes more important. You know your shit and thank you for sharing such important information. Reply @sundo-pf5zv @sundo-pf5zv 3 years ago (edited) Can Gallstones become autophaged during a starvation diet, such as when a patient has cholecystitis or pancreatitis and is slowly losing weight? Thank You in advance Reply @fatlosswithnova6098 @fatlosswithnova6098 3 years ago (edited) Thomas you’re an inspiration man ! 4 Reply @Danesniper97 @Danesniper97 1 year ago (edited) King this video was very informative, I had cancer and needed some clearness on this Reply @eddieyutub @eddieyutub 3 years ago (edited) Just what i needed! Thank you. Morphing time. Reply @burakdemir3546 @burakdemir3546 3 years ago (edited) Please give us the scientific break down Thomas ! Greetings from Germany Reply @samcampbell2048 @samcampbell2048 3 years ago (edited) Is it good to break a fast with sardines in brine? I know it's got a bit of fat in it but also high in omega 3 which makes me think it might be better than a protien shake for example Reply @justlookattheflowers4239 @justlookattheflowers4239 2 years ago (edited) I don't think one can flip from Mtor to AMPK with a green tea quite that easily. If your still metabolising protein from a meal then your not going to flick the switch like that, maybe the green tea during a fast to increase the Autophagy then. Reply @jnl0910 @jnl0910 3 years ago (edited) so if i do a back workout how do i activate mtor in my back? Or how do you get it to go past the bloodbrain barrier as you say? Reply @betteryourlifewithjoe7441 @betteryourlifewithjoe7441 1 year ago (edited) Would you cycle the bodies mTOR production? Or at least confuse the body once a month or every three? Or just stick too a balanced diet? Thank you Reply @LoreMIpsum-ng5my @LoreMIpsum-ng5my 3 years ago (edited) Thanks for this reminder - life is not black and white, it’s yin and yang; mtor and autophagy Reply @GucciLoafers_ @GucciLoafers_ 3 years ago (edited) Is it okay to use white tea instead of green tea? To balance the MToR Reply @tonyalex377 @tonyalex377 3 years ago (edited) THANK YOU THOMAS .U r the best ! & I hope to get more in depth in mTOR thingy. 1 Reply @mohameddjemli6826 @mohameddjemli6826 3 years ago (edited) Hey Thomas could you do a vidéo about working out during ramadan fasting .is'it good or bad ? Reply @haroldbafitis8483 @haroldbafitis8483 1 year ago (edited) Like your discussion// great way to share with my patients… and I will // Have most of my post op patients on intermittent fasting and a gluten free dairy free low sugar program.. NICE JOB H .BAFITIS DO MPH FACS PLASTIC SURGERY Reply @jeffg.3250 @jeffg.3250 1 year ago (edited) Great video. I've stopped taking collagen peptides because all the amino acids increase mTOR. Reply @alexander2685 @alexander2685 3 years ago (edited) God bless you man stay safe and healthy as always and god bless you and yours always. Reply @ganganaperera9405 @ganganaperera9405 3 years ago (edited) Very helpful! Thanks doc Reply @Anthony-vy5gw @Anthony-vy5gw 2 years ago (edited) Please do another video on MTOR and it's benefits and the downside of too much AMPK. The general vibe everywhere is demonizing mtor and glorifying ampk. No one talks about the extremes of each. Reply @vas4739 @vas4739 3 years ago (edited) Pleeeez Mtor might be my problem. Would you do a vid on benevolent pseudodiabetes which seems to be in a stuck position of Mtor and insulin resistance. I’m on keto over two years , fully fat adapted but sugars remain consistently between 135 > 159 even when I fast 50 hours! I fast 24 hrs 2x a month and no help! Reply @jeremygabato8974 @jeremygabato8974 3 years ago (edited) I wish somewhere in my life, using your mTOR analogy, a huge rock just falls and leads me down a path to those MASSIVE GAINS GOD DAMN BRO 6 Reply @eliuq4157 @eliuq4157 2 years ago (edited) MTor is amazing for muscle building and sustenance 🤩🤩🤩 Reply @karlunderhill2004 @karlunderhill2004 3 years ago (edited) Thomas, You have mentioned several times about herbs that will help autophagy… Which herbs: When to take Take with oils or with just water Please explain!!! Reply @curtissantos3137 @curtissantos3137 3 years ago (edited) all i know is i went from 289 pds to 190 in 9months thanks to thomas im believe me im soooooo chizeled!!!!! 👍👍👍👍👍👍😘😘😘😘😘 Reply @tonys8243 @tonys8243 3 years ago (edited) Mate love your stuff .... I reckon I get a new word /thing every time I watch one of your interesting posts. Reply @lesternicaragua4414 @lesternicaragua4414 3 years ago (edited) Have you ever done anything for diabetes keto or diabetes intermittent fasting? I would love to see my mom is a type2 diabetes Reply @paulgreen9675 @paulgreen9675 3 years ago (edited) Thank you for great content! Reply @dreliasgapp3352 @dreliasgapp3352 3 years ago (edited) Very explanatory....thank you so much...🙏🏻🙏🏻🙏🏻 Reply @jennyg5426 @jennyg5426 11 months ago (edited) More mTOR please. 1 Reply @lucasdeschamps9784 @lucasdeschamps9784 3 years ago (edited) Yes pls more on mTOR. Thanks for this vodeo too. Was great! Reply @salavea41 @salavea41 3 years ago (edited) Please do an in depth video on mTOR....Thank you Reply @gracesinger9903 @gracesinger9903 1 year ago (edited) And that is why metformin prevents muscle growth :/ this literally makes so much sense to me now Reply @karimatef551 @karimatef551 3 years ago (edited) every time that impressive look on my face when listening to you ! wow thomas keep that nerdy spirit up bro you're amazing !! 3 Reply @antonioperez7528 @antonioperez7528 3 years ago (edited) Nice Thomas. 1:30pm here & not the midnight. Lol Time to learn & get my groove on. 👍🏾😊🤙🏾💚 Reply @360xQUICKSCOPES @360xQUICKSCOPES 3 years ago (edited) Does a supplement labeled as an “mtor activator” have any correlation to risks associated with cancer? Seems like a lot of google searches pair these two, but it almost sounds like it’s talking about cancer therapy, not so much a healthy adult in the gym.. Is there concern? Reply @joshuaficek2491 @joshuaficek2491 3 years ago (edited) Yea more on it. But maybe an example schedule to follow. Like workout fasted then eat? Or what times best Reply @niceboy1020 @niceboy1020 3 years ago (edited) Hey mate, seen your keto coffee recipes and having trouble finding coconut cream... Is there anything that I can substitute in for that?? Reply 1 reply @jeroensmit5540 @jeroensmit5540 3 years ago (edited) Thomas please help me out. You said in a other video to eat some lean protein and carbs after a workout to grow muscle but Eric Berg said the body can regulate by itself with the growth hormoon and stick to de keto dieet with no carb loading at all. Reply @abby0824 @abby0824 3 years ago (edited) Yes more Mtor info 🙏 Reply @CaseyKCRichards @CaseyKCRichards 8 months ago As a pro bodybuilder it amazing me like the narrator who as a body that is achievable in one yr-( yes one year as i took a guy who never trained before he gained 32 pounds). Seems to have all the answers. But what i do know he has did his research. People listen to him because his body is achievable in a short period of time whereas with me being 5-7 260 pounds it has taken me over 40 plus yrs of learning and research ing everything to gain muscle mass. And yeah. I am not hitting your subscribe button. Autophagy is basically fasting to create new muscle cells. How easy was that. ? Reply @tracyjackson5052 @tracyjackson5052 1 year ago (edited) What are the chemicals in Green Tea and Matcha that inhibit mTOR? Reply @LemonWatermelon @LemonWatermelon 1 year ago (edited) Would it be good to fast for 22hrs workout on an empty stomach and have 1 large high protein meal after working out.. in a 2 hr feeding window.. 1 Reply @RegineBrady @RegineBrady 3 years ago (edited) The only way I made it through understanding your explanations is if I completely ignore your analogy😂😂 Reply @shredboise @shredboise 2 years ago (edited) Excercise also triggers autophagy Reply @alpharajput1938 @alpharajput1938 3 years ago (edited) Ckd is the best to increase mtor once a week and than fast with keto ❤️💪 Reply @mohammedyounus23 @mohammedyounus23 3 years ago (edited) Can you do a video on nuclei overload and a video on the effects of fasting on muscle nuclei and speak about satelite cells 1 Reply @rustybolts8953 @rustybolts8953 2 years ago (edited) Find something in nature that is not dependent on balance and you have a natural version of Stalan's boots. Even gravity has dark energy so I don't think anything exists that is not balanced or countered by something... Reply @johnny5139 @johnny5139 3 years ago (edited) You need some sound baffles in that studio, unless you want that echo in the room. 💛 2 Reply @Qugeer @Qugeer 3 years ago (edited) Do a video on Fasting in Ramadan Pleeeease :) Reply @Bunjamin27 @Bunjamin27 3 years ago (edited) I think Thomas should run his scripts through Grammerly or something to similar to help cut down the wordiness... geez. He's wordy to the point where he can be hard to follow because it's just a bunch of word salad Reply @fraool944 @fraool944 3 years ago (edited) Yeah Dude hit the Science hard on Mtor Reply @hanknelson3231 @hanknelson3231 3 years ago (edited) Opposing biological processes.....Interesting. Cosmic everything. To understand these processes is perhaps the first gate. Food opposes longevity, but coupled with fasting you get the best of both worlds. Reply @garroshhellscream2770 @garroshhellscream2770 3 years ago (edited) Autophagy really benefits from mtor because of muscle. ESPECIALY when fasting because autophagy will start tapping into the pure protine muscle for energy(atraphede) which is literaly the healthiest form of energy. Reply @MyFunnyShizz @MyFunnyShizz 3 years ago (edited) Please do more about mtor Reply @RegineBrady @RegineBrady 3 years ago (edited) As much as I know you love giving analogies, as I’ve repeated this in so many comments, they make it harder for me to understand! I appreciate your attempt so much, Thomas, but unfortunately it’d be great if you can stick to the science. We can understand it if you can break the science down. Thanks! Reply 1 reply @ernestmunjonejr3013 @ernestmunjonejr3013 11 months ago (edited) at 70 i would like to add some muscle safely I am currently trying fasting to trigger autophagy Reply @tracyjackson5052 @tracyjackson5052 1 year ago (edited) Does Vitamin B-12 activate mTOR? Reply @shainaterry4219 @shainaterry4219 3 years ago (edited) Please do a more in depth of mtor so i can't learn more about it Reply @online890 @online890 3 years ago (edited) Tomorrow is our fasting so we are doing dry fasting, can you tell us about dry fasting Reply @briangerds7643 @briangerds7643 3 years ago (edited) More mtor please Reply @branbeelotus @branbeelotus 3 years ago (edited) Wow this so went over my head Reply @ISTsports @ISTsports 3 months ago good presentation! Reply @brunorigo @brunorigo 1 year ago (edited) Do I have to choose between having muscles and live till 80 or skinny/lean for 250years? Reply 1 reply @lindabarnes5299 @lindabarnes5299 3 years ago (edited) Yes! more detail about MTOR, please 22 Reply @living4adrenaline @living4adrenaline 2 years ago (edited) Autophagy isn't happening unless you're in a fasted state.. Reply @colinconaty763 @colinconaty763 3 years ago (edited) Excellent Stuff.. 😁 Reply @milanpintar @milanpintar 1 year ago (edited) we're adapted to get super strong and sharp if we're looking for food. Reply @miguelmejia4656 @miguelmejia4656 3 years ago (edited) didn't you say autophagy doesn't happen in the brain in your last video? Reply @davidsitare9525 @davidsitare9525 2 years ago (edited) sir but bcaa and l carnitine doesn't works so why mTOR response in body Reply @eguapo @eguapo 2 years ago (edited) Great video! Reply @RegineBrady @RegineBrady 3 years ago (edited) Oh my goodness, I was thinking this wouldn’t be an advertisement video. Should have know. Thomas!!!!,😂😂😂😂 Reply @dylloncook6623 @dylloncook6623 3 years ago (edited) i would like to know more about mtor 36 Reply 2 replies @juniorandrew4159 @juniorandrew4159 3 years ago Thomas ur videos are always so quiet idk if it's the recording equipment but it's not normal video volume Reply @porchturds8149 @porchturds8149 3 years ago (edited) Thomas, how come you dont do live streams? Reply @courregeaaron947 @courregeaaron947 3 years ago (edited) Everytime he says growth I imagine him saying gross 🤣 3 Reply @mohammedyounus23 @mohammedyounus23 3 years ago (edited) Do another video with more details Reply @RybackTV @RybackTV 3 years ago (edited) Love autophagy. 9 Reply 1 reply @RamilMagyerramov @RamilMagyerramov 3 years ago MTor video, please! Reply @LC-yv9ey @LC-yv9ey 3 years ago (edited) does glycenate break a fast Reply @i1pro @i1pro 2 years ago (edited) This guy needs a whiteboard. English is my second language so I'm very visual.... Reply @onadorries3731 @onadorries3731 3 years ago (edited) I drink green tea and ginseng tea but I don't want visible muscles Reply @milanpintar @milanpintar 1 year ago (edited) but fasting increases growth hormones and increases lean muscle mass. Reply @britreed8038 @britreed8038 3 years ago (edited) So basically, this is a commercial for green tea? Reply @skwisgaarskwigelf331 @skwisgaarskwigelf331 3 years ago (edited) The Thomas Clock Strikes Again Reply @ahmedalasali9720 @ahmedalasali9720 3 years ago (edited) More about mTOR Reply @ankitasharma4809 @ankitasharma4809 3 years ago (edited) Much lv from india ♥️ 2 Reply @damiandamiano3651 @damiandamiano3651 3 years ago (edited) Yup, Berg and the Ball head dont under stand that, we need mtor, they do recycle because they are old Reply @lancelaw5966 @lancelaw5966 1 month ago Big conspiracy in med.community against muscle...men with muscles are treat pol.treat pol.treat Reply @ShaunSilk-ew7cy @ShaunSilk-ew7cy 2 days ago The dude in the video clearly has a shit ton of Mtor in his biceps, omg they are enormous!! And at a guess he's done the hard yards and isn't on steroids as he looks rock hard not like a marshmallow man!! Reply @AdriBeautyTutorials @AdriBeautyTutorials 3 years ago (edited) Nice ! Reply @berryvwjnr6481 @berryvwjnr6481 3 years ago (edited) MCT coffee in morning won't activate MTOR? found out that they both have protein, surely this will break the fast minutely, so to truly fast, just water? Reply @joegt123 @joegt123 3 years ago (edited) Yknow whats funny? I was about to ask what the hell's up with the name "mtor". Then I read the description. Reply @1crazednut @1crazednut 3 years ago (edited) Take-away ... we're not homogenous blobs ... at least some of us aren't. Reply @anjandeepsingh444 @anjandeepsingh444 3 years ago (edited) Thomas bro. Plzz make one video upon Masturbation - all about masturbation effects on fasting and muscle building or hormones Reply @jamesunderdal8976 @jamesunderdal8976 10 months ago (edited) Everything decreases longevity man supposedly so damned if you do damned if you don't could get hit by a bus tomorrow for that matter enjoy the life you have today because tomorrow is no guarantee. I will take the good health and 💪today. Reply @lightbeingpontifex @lightbeingpontifex 1 year ago (edited) This is the dilemma,,, Reply @RedMandMs @RedMandMs 3 years ago (edited) Working on it. You're saying "live hot" reminded me of this song. https://youtu.be/Cmul7jUyWRg Reply @trulyblockchain @trulyblockchain 9 months ago So we shouldn't take HMB..? Reply @michaelspencer2559 @michaelspencer2559 1 year ago (edited) first stop the sugar and carbs. wait a few weeks . see your results. then modify your results with wight training Reply @RositaCajasEchenique @RositaCajasEchenique 3 years ago (edited) Greetings from Costa Rica! I really appreciate your videos. But please don’t speak that fast with all those terms that are new and difficult for the common people. It’s difficult to keep us in track. Please slower will be the better, at least for me! Thank you! Reply @to-xh9lk @to-xh9lk 8 months ago Doesn't that tea have stuff that has insulin response like monk fruit? How you supposed to sip it all day when still fasting, I don't get it Reply @Audiofreund2 @Audiofreund2 3 years ago (edited) I am sorry but I just have to say it: man what a hot dad! 🍖🔥 Reply @atlantaswelder @atlantaswelder 3 months ago 👏👏 Reply @TheBadGuy0987 @TheBadGuy0987 3 years ago (edited) To be swole and old is the goal. 5 Reply @alienautopsy9326 @alienautopsy9326 1 year ago (edited) Thor has the most mTOR Reply @exoticspeedefy7916 @exoticspeedefy7916 3 years ago (edited) Watch Ted naiman, and you won't fear protien Reply @bullseyebearBTC @bullseyebearBTC 2 years ago (edited) Oolong and green tea Bubba. Reply @kweirmeir @kweirmeir 2 months ago mTOR didn't age well. Reply @rebella5769 @rebella5769 3 years ago (edited) Sorry, but I think matcha is disgusting. There's gotta b another way 1 Reply @micheall1127 @micheall1127 3 years ago (edited) Your muscles are big 1 Reply @keshaholloman3675 @keshaholloman3675 3 years ago (edited) Hello Thomas 1 Reply @JRR31984 @JRR31984 3 years ago (edited) SPEAK. Man. Reply @xubifit7660 @xubifit7660 3 years ago (edited) My apologies for being logged in as my business and leaving this comment. Reply @shainaterry4219 @shainaterry4219 3 years ago (edited) Hi Reply @MrBeckenhimself @MrBeckenhimself 3 months ago (edited) Why is this guy still making videos? He's made a fool of himself so many times already on this subject. You know what else increase mTOR? Eating protein! Yeah. And not only does it increase it it increases it by a lot. But don't take my word for it, look it up for yourself. But this guy doesn't know that. Edit. You know what else lowers mTOR? Aerobic traning. In other words cardio. Which is why is is superior to weight training. Reply @amel-jg5ui @amel-jg5ui 3 years ago (edited) Not First Reply 1 reply @nusense808 @nusense808 1 year ago (edited) Fear monger Reply @mreese8764 @mreese8764 1 year ago (edited) Growth is not the opposite of longevity. Shrinking is. This false equality makes everything you say wrong an confusing. Reply @MrAbrahamkadabra @MrAbrahamkadabra 3 years ago (edited) ↓ that's how many times he said mTOR 1 Reply @zeki972 @zeki972 3 years ago (edited) I'm sorry, but I'm disappointed mTOR protein MYSTERY unraveled | How to Live Longer and Look Younger Wellness Messiah with Rimon 78.8K subscribers Join Subscribed 126 Share Download Clip Save 2.5K views 1 year ago mtor protein MYSTERY unraveled: How to Live Longer and Look Younger What is the mTOR protein connection? … 27 Comments rongmaw lin Add a comment... @claudettesechler149 1 year ago (edited) Just what I needed to hear about, the role of Arginine! Too much of it sparks a shingle outbreak and it took a long time to figure it out. On the other hand, I do three hard workouts a week, I am 70 years old and I want to keep muscle mass so I keep my protein intake up..this was just so interesting! Thank you! 2 Wellness Messiah with Rimon Reply @robertshuster2126 @robertshuster2126 1 year ago (edited) Rimon, you have become my exclusive go-to guy.....you have my confidence.............and that comes from a super skeptical 82 year old science undergrad who has watched literally thousands of videos on health from CREDIBLE content providers since I became health conscious (about 5 years ago - I just want to live forever). Have you read Herman Pontzer's book 'BURN'? (You and he may be thinking on the same lines because some of your language relates to his and his thesis). Also what say you about osteoarthritis? cheers👍👍👍👍 3 Wellness Messiah with Rimon Reply @tallybrillembourg6211 @tallybrillembourg6211 1 year ago (edited) Thanking you again! Is there anyway I could get a consult from you to help me get my 40 to 50 grams of protein with a selection of foods you would recommend ? I need a proper list , perhaps to shadow what foods you consume. I’m grateful for whatever info you can offer me! 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @bernhardwalther @bernhardwalther 1 year ago (edited) Thanks for this video which covers a large subject. Would you consider doing a video about NMN ? 1 Reply Wellness Messiah with Rimon · 1 reply @skykid6485 @skykid6485 4 days ago keep going .. really helpful insight! 💯 Reply @elaxel1469 @elaxel1469 3 days ago You take for granted that reducing Mtor is ideal. But it's needed for building muscle after practising sport. And muscle is related to longevity, and ostheopenia to aging. Reply @evilsnowflake7414 @evilsnowflake7414 1 year ago (edited) Can you PLEASE explain how to use the image you show around 8:00 to calculate the minimum amount of amino acids I need/day. I don't understand how to use it based on my own weight, what parameters should I change etc.. 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @christianborwick2170 @christianborwick2170 4 months ago Great content Reply @A.K.76.A.K. @A.K.76.A.K. 1 year ago (edited) But what you mean 50 grams of protein? Because bio ability plant protein is low so you must eat much more then 50 grams. In case of for example eggs you can eat exactly 50 grams of protein (bio ability 100%) Reply @balanv7327 @balanv7327 1 year ago (edited) %whey protein per one meal? %Hemp protein per meal? If two meals a day, grams of protein each per meal? For health span and life span 1 Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply @roqclimber @roqclimber 9 months ago Proteins are Chains, Amino acids are the Links. Combining different Links results in different Chains. Reply @BiZii1024 @BiZii1024 1 year ago (edited) So we should restrict proteins (essential aminoacids) and carbs? So high fat diet are optimal? Reply Wellness Messiah with Rimon · 4 replies @felicisimomalinao1981 @felicisimomalinao1981 1 year ago (edited) Mammal meat/protein seem to increase MTOR, since humans are mammals. I prefer fish, eggs and occasional fowl. Reply @BR-hi6yt @BR-hi6yt 1 year ago (edited) So don't eat protein or carbs or take sports supplements if you want to live a long time? Wellness Messiah with Rimon Reply Wellness Messiah with Rimon · 1 reply What Is mTOR Pathway | Balancing the mTOR and AMPK Pathways to Slow Aging [2019] Lance Hitchings 69.5K subscribers Subscribe 986 Share Download Clip Save 24,558 views Jul 15, 2019 WHAT IS MTOR PATHWAY? If you want to slow the aging process, then you should be taking a look at balancing the activation of the mTOR pathway with the AMPK pathway. Both are needed as an aging adult, yet are mutually exclusive. The mTOR pathway is great for growing new muscle and staving off sarcopenia, but the AMPK pathway is required to clear out the toxic by-products that mTOR create. In this video, we’ll be talking about what the mTOR pathway is, and how too much of a good thing is not good for you. We’ll also go into how balancing the mTOR pathway by activating AMPK is a good thing. And finally, we discuss how to do both, and achieve optimal balance between the two. Chapters View all Transcript Follow along using the transcript. Show transcript Lance Hitchings 69.5K subscribers Videos About 207 Comments rongmaw lin Add a comment... @theophilusmann7869 @theophilusmann7869 4 years ago (edited) Finally, a balanced and clear explanation on mTOR and AMPK pathways. 18 Reply Lance Hitchings · 1 reply @davidlizarazo526 @davidlizarazo526 4 years ago (edited) You're incredible, explaining those complex physiological processes, allowing people to understand them thus make them capable to improve their health, this is what i call quality content 8 Reply Lance Hitchings · 1 reply @forajc @forajc 4 years ago (edited) Outstanding work, you are filling a niche by breaking these complex topics down and building up the understanding step by step. 12 Reply Lance Hitchings · 1 reply @annanicassio8228 @annanicassio8228 3 years ago (edited) Love all the science and information! I’ve been curious about mTOR for a while and you explained it better than anyone I’ve heard speak on this topic! Thank you! 4 Reply Lance Hitchings · 1 reply @krazyk500 @krazyk500 2 years ago (edited) Just found this video. You found a great balance between science and practicality. Thanks for sharing your knowledge and experience 1 Reply Lance Hitchings · 1 reply @tomprovan6817 @tomprovan6817 4 years ago (edited) The more science the better I like detailed pathway diagrams. Great stuff keep up the good work. Another piece of information that's useful is the fact that one needs protein to build neurotransmitters to make your brain function properly. 2 Reply Lance Hitchings · 1 reply @Reellex1 @Reellex1 4 years ago (edited) Very informative video. For more improvements I recommend you to add some cited studies in the description of the video. I think this would be even more informative for those who want to deeply understand some of the technical mechanisms and processes. 1 Reply Lance Hitchings · 1 reply @barbarahenderickson4077 @barbarahenderickson4077 10 months ago I love his clear explanation of mTor. I was searching and listening to many channels. This one was interesting, simply put and the knowledge easier to implement. Thank you Lance!!! Reply Lance Hitchings · 2 replies @pete10034 @pete10034 3 years ago (edited) Great video! Optimizing responses to endurance vs strength training is the cutting edge of research today Reply Lance Hitchings · 1 reply @kirstym3351 @kirstym3351 3 years ago (edited) I really like the level of detail in these videos - thanks for making this much clearer. 1 Reply Lance Hitchings · 2 replies @thisthat1142 @thisthat1142 3 years ago (edited) Love the science, love the pace. Excellent channel. Thanks! Reply Lance Hitchings · 1 reply @DocJaeBass @DocJaeBass 4 years ago (edited) On the late freight here, but will give my views anyway. Yes on the new studio. I like it. Also an absolute yes on the science. Like many other commentators I am impressed with your ability to make it understandable. Because the longevity and age reversal issues are so complex I fewl it is very helpful to build up an understanding of the science that supports the superstructure of the activities such as IF, HIIT, and resistance training plus diet and supplements. Oh yeah, the science is important so please continue. Now for this video's content. I'm watching this in December, so a few months after posting. Are you still doing the on and off high low protein coupled with resistance training? In the video you mentioned the protein you take. I'll have to go back to get the name. Would you consider doing a video on why you chose this protein supplement. Reply Lance Hitchings · 2 replies @jamesdonnelly8888 @jamesdonnelly8888 4 years ago (edited) Excellent vid as always. Thumbs up on the new set, you have a great eye. The obvious tools to mention are metformin and berberine. Not a fit for your program of cycling, but I believe many people feel they don't pose obstacles to your fitness goals. There is even evidence they work better together. 2 Reply Lance Hitchings · 2 replies @ameetkallarackal6977 @ameetkallarackal6977 2 years ago (edited) Hi Lance, really informative video. Personally really like your balance of science and recs. Question for you - given that rapamycin "tricks" the body into thinking that there's less caloric availability and inhibit mtor, what would happen to calories if you took rapamycin while having caloric abundance? It sounds like autophagy recycles existing amino acids so I'm curious what would happen to new calories in this case. Thanks! Reply Lance Hitchings · 2 replies @brianalbiter1852 @brianalbiter1852 4 years ago (edited) I appreciate all the sciency details, followed by a quick summation to tie the complex stuff together. 2 Reply Lance Hitchings · 1 reply @thomasrebotier1741 @thomasrebotier1741 1 year ago (edited) So you want to keep weight lifting and HIIT quite separate. What is the kinetics of those activations/inhibitions? Can you efficiently switch from MTOR to AMPK over a 48h cycle? Reply @gonzsori @gonzsori 3 years ago (edited) This video is great!! I understood very much about the subject. It never has been so clear to me. Thank you very much. 1 Reply Lance Hitchings · 1 reply @quittobaccotoday @quittobaccotoday 1 year ago (edited) Good info. Helped me get some things straight in my mind. My plan is different than yours, but similar. I'm using IF and actiponin to activate autophogy, and just sticking with protein and accentuating the eccentric and loaded stretching weightlifting moves to activate mTor. Also finish my workouts with the big leg muscles to boost hgh 1 Reply @stonebridge7710 @stonebridge7710 4 years ago (edited) I'm most intrigued with the Mtor balance puzzle you present, but first, production comments: Nice basement studio, Lance. Nice new format, the CC is better positioned on my screen. Excellent use of infographics. Fun puzzle of what's the best mix of HIIT, weight training, amino acid supplementation and, in my case, my weekly dosing of Rapamycin? I'll be researching weight training recovery times, maybe doing the most resistance training 3 days after (and 4 days before) my dose of Rapamycin. Since I've been on Rapamycin (5 months) and increased my HIIT training, my resting heart rate is lower than it has ever been in my life - including my extremely athletic state at age 30. My athletic performance now is pretty good and I am tracking it. Please continue the science detail in at least some of your videos, perhaps researchable links, as well. 1 Reply Lance Hitchings · 2 replies @stanleystark1842 @stanleystark1842 9 months ago Love your explanations. I love the biochemistry of mechanism of action. Reply Lance Hitchings · 1 reply @EssentialTruth @EssentialTruth 1 year ago (edited) I like details and its great the way you explain things... keep it coming as it is! Reply @enricopuno8276 @enricopuno8276 3 years ago (edited) I always hear mTor, AMPK, Sirtuin etc. But nothing better explanation than what you did. Good job 1 Reply Lance Hitchings · 2 replies @garyr1934 @garyr1934 1 year ago (edited) You’ve just answered my most pressing questions as to how to take my extensive suite of DoNotAge supplements And even better you take perfect aminos !! and I just received my new shipment of 12 bottles of powder Abd three bottles of tablets So I’ll follow your dosages I love your logic I’ll face to see through a call tomorrow with a DoNotAge representative how to maximize the balance of MTOR Abd AMPK Lance I’m 61 next month and very lean and muscular and very toned I plan to stay that way You really do great work here I like the basement studio BTW Cheers From New York City Reply @alfredoalarconyanez4896 @alfredoalarconyanez4896 8 months ago Thank you, I loved your scientific explanations! Reply Lance Hitchings · 1 reply @creightonfreeman8059 @creightonfreeman8059 4 years ago (edited) Very good physiological information! In one of Dr. David Sinclair's talks he mentions Metformin and Green Coffee Extract both activate the AMPK pathway. Presumably alternating between resistance training/essential amino acid days (anabolic days) and Metformin or Green Coffee Extract and less amino acid days (catabolic/autophagy) with rest would be one method of pulsed therapy. Dr. Sinclair emphasizes that no one knows yet what the optimal regimen is for this kind of anti-aging therapy. It would be great if people pursuing it would keep records and do either the DNA methylation blood testing or telemerase length testing and contribute their data to some centralized database so that we could determine what the optimal protocol is. I believe William Faloon's (of The Life Extension Foundation) non profit organization is compiling such a database but I forget the name of his non-profit at the moment. Reply Lance Hitchings · 1 reply @karlfillmore57 @karlfillmore57 2 years ago (edited) Hi, Lance. This is Max from Debbie's class at OCHS. I think you pretty well nailed the subject here. I don't really lift but I hit the Bowflex a couple times a week and I like to follow that with a big mug of hot chicken sipping bone broth into which I have added 20 gm of collagen peptides from cow hide. It has all the AA's except for tryptophan and best of all only 106 mg of Methionine. At 90 kg body weight my RDA for Methionine would be about 900 mg and this leaves me room for the egg, goat cheese, and fish in my diet. This seems to work pretty well for me. Liked the video. Now can you please explain how to cure cancer and balance the federal budget? Thanks. Reply Lance Hitchings · 4 replies @kilometreafterkilometre @kilometreafterkilometre 11 months ago (edited) bro i want u to add more scientific data as u do or asked if we liked it? yes i do, don't stop adding science/how it actually works things. 💗 love from india Reply @themarketingblacksheep8399 @themarketingblacksheep8399 3 years ago (edited) Based on the science of mTOR and AMPK, what would you think of an alternating stack for fasting- NAD+ during the fast and Berberine or even better, Dihydroberberine during the feeding window? Reply Lance Hitchings · 2 replies @johndwyer54 @johndwyer54 4 years ago (edited) Nice new set. Keep up the great work, Lance! 1 Reply Lance Hitchings · 1 reply @ronstanley9873 @ronstanley9873 4 years ago (edited) I enjoyed your video,and I think you might be on to something,with balancing the Mtor pathway in the manner you are suggesting,I dont do heavy weight training,I do however fast on average 16 to 18 hours a day,and do a mild form of HIIT training in the morning fasted.I have noticed at 62 years of age,some sarcopenia,but I am not too concerned with it,I am more concerned about extending lifespan,,I am following some of Dr David Sinclair's protocol,by taking Pterostilbene,MNM's Resveritrol MK7 and a few other things, I also am coupling this strategy with a form of relaxation and de stressing techniques to keep cortisol levels in check...thank you Ron Stanley. 1 Reply Lance Hitchings · 1 reply @donaldbarry5074 @donaldbarry5074 2 years ago (edited) Methionine is pronounced me THY on ene. Kinase is KY naze What you propose is consistent with what David Sinclair of Harvard, a major anti-ageing researcher (I’m sure you’ve heard of him) and others seem to be saying. I think this is a very complex subject and while I am following a similar regime I think the current picture will develop with time. Current thinking may then appear slightly naive. But that’s inevitable of course - humans can’t be researched like lab rats/mice. Until then I would like see the importance of the micro-organisms in our diet/biome and diurnal rhythms of optimal fasting integrated into the scheme by experts. Reply @joshuacorona8155 @joshuacorona8155 2 years ago (edited) VERY CLEAR! VERY TECHNICAL BUT EASY TO UNDERSTAND. I LIKE THE STYLE HOW YOU MAKE TECHNICAL EASILY UNDERSTABLE. IT IS VERY CLEAR AND COMPLETE INFO EVEN IS SHORT VIDEO. I FOUND EVERYTHING I NEED TO KNOW, AND VERY SATISFYING INFORMATION. Reply Lance Hitchings · 1 reply @Roger-Bowman @Roger-Bowman 1 year ago (edited) Nice video and appreciate the good explanation! Reply Lance Hitchings · 1 reply @menemenetekel9997 @menemenetekel9997 4 years ago (edited) The best explanation yet! Thank you & God Bless! 2 Reply Lance Hitchings · 2 replies @billmcdonald3544 @billmcdonald3544 3 years ago (edited) Smart guy. All reference data he uses is consistent with what I've learned from multiple other credible sources. His conclusions about interpretation of the data and actions to take make sense. Reply Lance Hitchings · 1 reply @malikmatatv.1476 @malikmatatv.1476 1 year ago (edited) The key is periodic fasting for 5 days for authopagy and then eat all protein in 25 days.. according to leo and longevity if you fast for 5 days your IGF-1 will slow down for 15 days... 1 Reply 1 reply @kenwitness5844 @kenwitness5844 2 years ago (edited) I know this is a 2 year old video but I got a lot out of it. The main reason I hunted videos like this down is for the science. Thank you. Reply @mdmommy @mdmommy 1 year ago (edited) I found you because I was looking for the science I appreciate it actually I'm a medical doctor who graduated in 1995, so this information on the m TOR pathway was not available when I learned physiology, and since I don't work in primary care amd directly woth nutrition I really haven't learned about it . I have a personal interest in nutrition all my life as an athletic person and also wanting to stay healthy, but I'm trying to learn more about health , nutrition and review what I've learned on the past as I am now an Ayurvedic health coach.. so this is very helpful. thank you. your background is fine but between your little scenes when the screen jumping up-and-down ,,,that's annoying... you can change the transition and that will be more smooth. A blackboard or diagram even a simplified one will help, too? Otherwise, clear and concise. Reply @duttanandmalari2329 @duttanandmalari2329 3 years ago (edited) Please definitely keep talking the science... You can always give us a time stamp if someone wants to skip the science part. 1 Reply Lance Hitchings · 1 reply @ravindersingh-uk5xf @ravindersingh-uk5xf 2 years ago (edited) Thanks for making this easier to understand. Reply Lance Hitchings · 1 reply @gangulashivani597 @gangulashivani597 1 year ago (edited) hi lance your information is absolutely mind blowing but what i request you is it requires previous science background. if u can make things easy for normal people it helps and reaches more mases please do consider Reply @Aestheticadilifts @Aestheticadilifts 3 years ago (edited) Great knowledge love the science stuff👍 Reply Lance Hitchings · 1 reply @judoubledb @judoubledb 2 years ago (edited) Great video breaking down a complex topic in terms everyone can understand. Wanted to help you out with the pronunciation of Methionine: meth-eye-oh-neen. At least that’s the only way I’ve heard it pronounced in the USA. Reply Lance Hitchings · 1 reply @maydelex @maydelex 1 month ago This is the best vide that clearly explained the working of the Mtor pathway and ampk. God bless you fr this wonderful explanation Reply @rahulhumanist @rahulhumanist 1 year ago (edited) Well explained. Reply @johndwyer54 @johndwyer54 4 years ago (edited) Yes, keep the technical detail coming! 1 Reply Lance Hitchings · 1 reply @erwinrogers9470 @erwinrogers9470 1 year ago (edited) Love the attention to detail Reply @altonparris3252 @altonparris3252 3 months ago Great breakdown of Mtor!! Reply @beautycorner2085 @beautycorner2085 4 years ago (edited) a real Genius. Awesome explanation Reply Lance Hitchings · 1 reply @sgtcrash4775 @sgtcrash4775 3 years ago (edited) I started at 330lbs i am at 265ish now in 5 months.. now I'm starting to build alot of muscle ... I got 11B mTOR Active to help my gains.. now after watching this im not sure lol .. I am still at a calorie decrease of 1200 or less daily.. I go to gym everyday for 1 to 2 hours... should I not take these ? Reply Lance Hitchings · 1 reply @1Lightdancer @1Lightdancer 2 years ago (edited) Awesome series - Have you seen any work from Alan "Mushroom" Kapular of Peace Seeds in Corvallis? (Basically retired now, his daughter and her husband have Peace Seedlings) He has done a lot of research on for plants and plant communities, including the abundance of "other" tubers from Peru (beyond potatos) ....Alan comments that the pods of both green peas and beans have well absorbed amino acids - Reply Lance Hitchings · 1 reply @lunadelmar6500 @lunadelmar6500 4 years ago (edited) I think there is some special research in the medical field about DNA regeneration to slow down the cell in charge of aging 2 Reply 2 replies @ronrg9518 @ronrg9518 6 months ago Great info, thanks Reply @jameschesterton @jameschesterton 8 months ago Good video, I suppose the biggest question is whether or not we really should be living longer and longer, we are already overpopulated and struggling to sustain life on the planet as it is. Reply Lance Hitchings · 1 reply @rossorosso @rossorosso 1 year ago (edited) great video man! Reply @themarketingblacksheep8399 @themarketingblacksheep8399 3 years ago (edited) actually, adding Yohimbine during the fast could help too Reply @gorp2647 @gorp2647 1 year ago (edited) Why not discuss how fasting fits in? Presumably, autophagy cranks up because there then is a lack nutrients. Thusly, mTOR would not be activated. Then, when I'm not fasting and doing HIIT, mTOR would be inhibited boosting AMPK allowing autophagy too. Could you comment here s'il vous plait? Reply @606pretty @606pretty 2 years ago (edited) IM LEARNING SO MUCH ON MY CALORIE RESTRICTION DIET!! Reply @KThalman @KThalman 10 months ago I eat plant based protein for lower BCAAs overall but supplement with BCAAs when I work out. Reply @dianteshamrok841 @dianteshamrok841 4 years ago (edited) #lancehitchings shall remains among scientist legend 4 Reply Lance Hitchings · 1 reply @isabelladurazo4196 @isabelladurazo4196 4 years ago (edited) More scientific terms are great! 1 Reply Lance Hitchings · 1 reply @markberger66 @markberger66 4 years ago (edited) Enjoyed the video. Just a small correction. Methionine is pronounced ed meth-i-oh-neen. 1 Reply Lance Hitchings · 1 reply @eguapo @eguapo 2 years ago (edited) Good video. Thanks Reply @anthonyanthony284 @anthonyanthony284 2 years ago (edited) Great discussion but I don't think this will work man. Your muscle growth and repair doesn't just take place on the days you weight train, certainly not only 2 hours after when you take your amino drink. You do your most growth and repair on the days you rest. Also, while HIIT training on your non weight training days activates AMPK instead of MTor, you are still damaging muscle tissue and you need protein for repair as well. Reply Lance Hitchings · 1 reply @monicalatvenas1348 @monicalatvenas1348 4 years ago (edited) I’ve been taking 20-40 gm of collagen peptides every day... which means I have been activating emtor ..😱 5 Reply Lance Hitchings · 3 replies @kylekrantz3025 @kylekrantz3025 2 years ago (edited) Trehalose can produce autophagy independently of mTOR, so autophagy can be produced without mTOR inhibition. But I’m in psych and I was curious about something. Increasing MTOR signaling stimulates neuritogenesis, this is how psychedelics grow ur brain, how do we activate mTOR neuritogenesis while increasing longevity. Can we inhibit mTOR for most of the day but then stimulate it when we are in that really hard class? What are the durations of mTOR activation? Reply Lance Hitchings · 1 reply @catchmeifyoucan2019 @catchmeifyoucan2019 4 years ago (edited) There should be more taxes implemented in this type of field 2 Reply Lance Hitchings · 2 replies @kariahlukemacchan2230 @kariahlukemacchan2230 4 years ago (edited) Thanks for information, how long have you used this strategy? To give us an idea, how old are you and what age do you feel? Reply Lance Hitchings · 3 replies @adamcohen6719 @adamcohen6719 3 years ago (edited) Nice talk but you completely missed the boat on autophagy and ampk activation, which really only occurs during severe calorie restriction or, ideally, fasting >24 hrs. If you continue to consume aminos then you will inhibit autophagy. 1 Reply Lance Hitchings · 1 reply @brendanlinane5376 @brendanlinane5376 2 years ago (edited) Great explanation 1 Reply Lance Hitchings · 1 reply @raydavis3535 @raydavis3535 3 years ago (edited) That's his personal strategy. In other words intermittent fasting is not for him. Intermittent fasting is the best way to balance the two. 1 Reply Lance Hitchings · 1 reply @kjjacobs9487 @kjjacobs9487 4 years ago (edited) Also also Also. Mtor Vs AMPK aka cell growth vs cell apoptosis or atophogy. But how do u feel about BUILDING muscle while also getting the benefits of AMPK? Both can’t be done at the same time. I try to activate MTOR in the morning by Aminos and workouts but in the afternoon I restrict calories or Fast for the AMPK but im having a hard time trying to find the sweet spot when it comes to timing for both. 2 Reply Lance Hitchings · 1 reply @prashantkumarsingh3643 @prashantkumarsingh3643 2 years ago (edited) Doing great job sir Reply Lance Hitchings · 1 reply @JolicoeurAbear @JolicoeurAbear 2 years ago (edited) berberine only inhibits the mtor partially, not completely. correct? will I still get good benefit from Hiit while taking berberine? Reply Lance Hitchings · 2 replies @pablocohen @pablocohen 3 years ago (edited) Thank you! 1 Reply Lance Hitchings · 1 reply @awestphal9602 @awestphal9602 3 years ago (edited) You could become an effective spokesperson on peptides given your present knowledge of human performance. I encourage you to make a study of peptide therapy and present your recommendations on peptide use. Check out the present YouTube podcasts on this topic . Reply Lance Hitchings · 1 reply @rdance3 @rdance3 2 years ago (edited) How can Perfect Amino claim zero calories? Amino Acids have Carbon. Methionine, for example, leaves the Methionine Cycle, via the Transsulfuration Pathway, and contributes to the TCA Cycle. 1 Reply Lance Hitchings · 3 replies @alexanderm6862 @alexanderm6862 3 years ago (edited) Great video Reply Lance Hitchings · 1 reply @sweetbon76 @sweetbon76 1 year ago (edited) Could methionine be part of the explanation why vegetarians live longer? Reply @ginasomara267 @ginasomara267 1 year ago (edited) All about this!! Reply @bethpulliam803 @bethpulliam803 2 years ago (edited) Does a cycle of Anavar have anything to do with this? 1 Reply Lance Hitchings · 1 reply @mkoschara @mkoschara 2 years ago (edited) Here's a comment: I want to slow down aging but am unsure about extending my lifespan. Reply Lance Hitchings · 2 replies @vilashambarde664 @vilashambarde664 4 years ago (edited) Sir plz tell me about ' Phosphatidic Acid ' supplement..does it works..? Reply Lance Hitchings · 2 replies @garyssimo @garyssimo 10 months ago (edited) good info! thx. we dont need music in background. Reply 2 replies @gnadehundgermanshephards6780 @gnadehundgermanshephards6780 2 years ago (edited) Keep the scientific information Reply Lance Hitchings · 1 reply @ryanward7608 @ryanward7608 6 months ago Came here after hearing about simufalim regulating mtor Reply @MsYoutuebchen @MsYoutuebchen 8 months ago Lance, I really appreciate all your contributions. Thank you. However, I found it extremely difficult to listen to this particular clip. The music is so distracting and doesn‘t add anything of value. Of course, I‘m only speaking for myself here. Reply Lance Hitchings · 1 reply @damiandamiano6377 @damiandamiano6377 3 years ago (edited) i have 24 h a day i fast 16 h and eat for 8 hours , i know all mtor inhibitors and use them daily but how can i balance my lifestyle so the body will rebuild and repair tissue with what i eat and drink and when to shut down this process in order to build muscule and live properly , i am making mistakes with IF i know that because i keep losing muscle mass get ROS attacks lose mitochondria Reply Lance Hitchings · 1 reply @travissmith2383 @travissmith2383 5 months ago What is the Perfect Amino Shake? Reply Lance Hitchings · 1 reply @wehaveitall2.0 @wehaveitall2.0 3 years ago (edited) Wouldn't fasting work? 1 Reply Lance Hitchings · 1 reply @joetart9905 @joetart9905 1 year ago (edited) There is no such thing as protein with no calories, unless it is non-digestible. Reply @timkunde8572 @timkunde8572 1 year ago (edited) So when do you fast if i may ask Reply @dohoodratstuffwithfriends8548 @dohoodratstuffwithfriends8548 3 years ago (edited) Could This help with Corona recovery 1 Reply Lance Hitchings · 1 reply @wehaveitall2.0 @wehaveitall2.0 3 years ago (edited) How much protein is 6 scoops? 1 Reply Lance Hitchings · 1 reply @Mrstevebro56 @Mrstevebro56 2 years ago (edited) Science is good Reply @damiandamiano3651 @damiandamiano3651 1 year ago (edited) i will give you sub old man because you dont sell anything Reply @skeeterskater5884 @skeeterskater5884 2 years ago (edited) Meth-eye-onine Reply @angelaknell3510 @angelaknell3510 2 years ago (edited) This video is very hard to listen to. Your voice is not very clear maybe you should get your voice box checked out for vocal polyps and why the background music it’s not needed and makes it worse. The background set is pretty depressing as well. 1 Reply Lance Hitchings · 1 reply @JulianEcho @JulianEcho 2 years ago (edited) Forgive me for being sceptical but you don't look like you're managing aging very well. Reply Lance Hitchings · 2 replies @valdsmt @valdsmt 2 years ago (edited) raspy voice was distracting Reply Lance Hitchings · 1 reply @MrYoubet @MrYoubet 3 months ago good job Reply METHYLENE BLUE: Impacts Longevity By Boosting Mitochondrial Efficiency [2024] Lance Hitchings 69.5K subscribers Subscribe 736 Share Download Clip Save 11,159 views Jan 9, 2024 My long-awaited video on Methylene Blue covers just about everything I know about this compound. Methylene Blue’s primary claim-to-fame lies in it’s ability to boost ATP production and increase mitochondrial efficiency. In today’s video, we’ll talk about what Methylene Blue is and it’s history. Then we’ll dive into how it works, with an introduction to cellular respiration. Finally, we’ll go into it’s impact on the aging process, how to take Methylene Blue and some considerations when supplementing with this molecule. ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• Chapters & Timestamps: Intro: 00:00 What Is METHYLENE BLUE? : 01:12 Laying The Groundwork: 02:36 Free Radicals: 07:09 METHYLENE BLUE: 09:24 METHYLENE BLUE's Also Neuroprotective: 12:21 METHYLENE BLUE Inhibits Skin Aging: 14:26 How To Take METHYLENE BLUE: 14:54 ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• Studies Refered To In This Video: The Potentials of methylene blue as an anti-aging drug: https://www.ncbi.nlm.nih.gov/pmc/arti... Multimodal randomized functional MR imaging of the effects of MB in the human brain https://pubmed.ncbi.nlm.nih.gov/27351... Ultraviolet radiation protection potentials of metheylene blue for human skin and coral reef heath: https://pubmed.ncbi.nlm.nih.gov/34050... Anti-aging potential of methylene blue for human skin longevity: https://www.ncbi.nlm.nih.gov/pmc/arti... Hemoglobin, methylene blue and oxygen ingteraction in human red cells: https://jpet.aspetjournals.org/conten... ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• Social Media: Facebook: / lancehitchings Instagram: / lancehitchings Twitter: / lancehitchings ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• AFFILIATE LINKS: Get a free month of Whoop using this link: https://join.whoop.com/35071A Discount code for Renue By Science: LANCE10 Product Links: https://alivebyscience.com/all-produc... Discount code for DoNotAge: LANCE Annual Subscription: https://donotage.org/subscribe/ Products: https://donotage.org/products/ Discount Code for Perfect Amino: HITCH10 PerfectAmino Drink Powder link: http://affiliates.bodyhealth.com/idev... Chapters View all Transcript Follow along using the transcript. Show transcript Lance Hitchings 69.5K subscribers Videos About 20:06 Glycine & NAC: Can They Transform The Way We Age? [2023] by Lance Hitchings 66K views · 5 months ago 132 Comments rongmaw lin Add a comment... @cocis911 @cocis911 2 days ago Thank you so much for all the effort it must have taken to produce this video. It's excellent. I think it'd only be improved by making references to the research papers that support MB's properties so we know how much evidence there is and what quality that evidence is. 1 Reply @lomotil3370 @lomotil3370 3 days ago 🎯 Key Takeaways for quick navigation: 00:29 📜 Methylene blue is a compound that shows significant potential in impacting aging and longevity. 01:19 🔄 Methylene blue, historically used as a dye and medication, has a long safety record and is on the World Health Organization's List of Essential Medicines. 02:19 ⚡ Methylene blue acts as an "electron cycler," similar to NAD, shuffling electrons to enhance cellular respiration and ATP production in mitochondria. 03:39 🔗 Cellular respiration involves Glycolysis, the KREBS Cycle, and Oxidative Phosphorylation, with the Electron Transport Chain (ETC) playing a crucial role. 05:59 🌐 Methylene blue's presence in mitochondria increases ATP production efficiency by enhancing the function of complex 4 in the ETC. 07:23 ⚠️ Free radicals, formed during cellular respiration, contribute to intrinsic aging; antioxidants like methylene blue counteract this damage. 09:16 🧠 Methylene blue's neuroprotective and nootropic capabilities include enhancing brain cell respiration, improving memory, and increasing attention. 11:54 🩸 Methylene blue improves oxygen-carrying capacity in red blood cells, explaining its use in treating carbon monoxide poisoning. 12:50 💡 Methylene blue's hydrophilic and lipophilic nature allows it to penetrate biomembranes, including the blood-brain barrier, enhancing its neuroprotective effects. 13:38 😌 Beyond cognition, methylene blue has anti-depressant effects, inhibits skin aging, and can promote wound healing. 15:55 💊 Methylene blue is recommended in a 1% solution form, with dosages varying based on body weight, and precautions against serotonin syndrome should be considered. 18:50 ✅ Methylene blue offers a range of benefits, including boosting energy levels, enhancing cellular function, and potentially addressing mitochondrial dysfunction, making it a compound worth considering for anti-aging supplementation. Made with HARPA AI 16 Reply @MarcMallary @MarcMallary 2 days ago (edited) You learned it good and explained the process better than some doctors. I've been mixing it with vitamin C, that turns it more clear. I heard it explained that it makes it work better. I use the powdered with a tiny spoon. 2 Reply @0l_pops531 @0l_pops531 3 days ago Best schematic explanation I've seen yet on the electron transport chain (ETC)... great work Lance. I'm saving this video for future reference. 12 Reply Lance Hitchings · 1 reply @franklanham6936 @franklanham6936 3 days ago Great video Lance. I went through a period last year when I was interested in methylene blue, but it was so complex I decided to shelve it for the time being. Your video is very good at elucidating what’s going on with MB. I may add it to my stack this year. By the way, how long does your mouth stay blue after taking a dose? Is there anyway to avoid this effect? Thanks again Lance for the fantastic content! 1 Reply Lance Hitchings · 3 replies @alf2009100 @alf2009100 3 days ago Great video 👍. I’ve been doing the blue for a couple of years and about a year ago I came across a video with a doctor Thomas Levy telling how adding about a gram of ascorbic acid to the blue dose in warm water makes some kind of chemical harmonious music. 🎶 The blue faded to clear after about a minute in the glass but I am still pissing a lovely blue or green depending on my vitamin B intake. Easier to drink and I believe it’s a very beneficial way to take the blue 🔵 2 Reply @richdamico7524 @richdamico7524 2 days ago Best schematic explanation I've seen yet on the electron transport chain 3 Reply Lance Hitchings · 1 reply @melissastewart8955 @melissastewart8955 2 days ago Thanks for the thorough discussion. Much appreciated. 1 Reply @christopherdavis9883 @christopherdavis9883 3 days ago I had a UTI for about a month, wouldn't go on its own. I refuse to take anti bi's unless absolutely necessary. Discovered MB, 20 drops in 4 oz of water. UTI gone in about 4 days, never returned. I take MB regularly now just for regular health benefits Inc as a nootropic 👍 14 Reply Lance Hitchings · 1 reply @carebear8146 @carebear8146 3 days ago A different perspective on MB dose and cost effective. Dr Mercolla just had a podcast where he talked dose recommendation and was was much lower. He and Georgi Dinkov both recommended only 1mg a day for longevity (not other disease process etc) DR M recently pointed out that a gastroenterologist Sabina Ali pointed out MB destroys bifodobacteria in the gut. Also George said in MG doses can cause serotonin syndrome if taken with SSRI drugs. 4 Reply Lance Hitchings · 4 replies @TomHimanen @TomHimanen 1 day ago (edited) MB is something I have been keeping on eye on for long. But this was the first practical video I have bumped knto and thanks for that! Could you go even more practical and create a tutorial video about production of DIY solution? Reply Lance Hitchings · 2 replies @armaugh @armaugh 3 days ago Some researchers have suggested that mitachondrial dysfunction is responsible for diabetes mellitus and is primarily caused by seed oils end-products "gumming" up a cell. Do you think Methylene Blue would/could improve mitachrondrial function? 1 Reply Lance Hitchings · 2 replies @nickb1868 @nickb1868 3 days ago This stuff was and is a game changer for my CFS. 5 Reply Lance Hitchings · 11 replies @teddybearroosevelt1847 @teddybearroosevelt1847 3 days ago So one big question is: where do you buy high quality methylene blue at a reasonable price? Then after that, another important question is: how do you use it without dying your teeth blue or creating blue stains in your kitchen/house? 4 Reply 3 replies @jdtransformation @jdtransformation 3 days ago Question: if someone is going to be taking 50~100mg a day, can you bypass the hassle of diluting to 1% solution (and then so many drops... which turn your mouth blue)... couldn't you just take the powder, weigh, and put in a tiny capsule? Seems way more convenient. 1 Reply Lance Hitchings · 2 replies @ryanastoner @ryanastoner 2 days ago Dude, great freaking work on this video. Reply Lance Hitchings · 1 reply @patrickday4206 @patrickday4206 15 hours ago Anything methylated is something to be careful liver wise but for some strange reason MB seems to be an exception 1 Reply 1 reply @JonathanOvnat @JonathanOvnat 1 day ago Great video! Thank you! Reply @billelbaid @billelbaid 1 day ago Hello, Thank you for you very well documented video! My question is about how to take it… you take these drops of MB in a glass of water or juice, but how not to get your mouth or tongue BLUE? Reply @jamesslack8933 @jamesslack8933 3 days ago At what doses does it not destroy the gut microbiome? Reply @pjaworek6793 @pjaworek6793 1 day ago Oh oh, part 2! Unless I spaced out, I didn't hear any mention of topical uses. 1 Reply Lance Hitchings · 1 reply @VTVT1306 @VTVT1306 3 days ago More and more curious to see the supplement stack Reply Lance Hitchings · 2 replies @nrsrchd @nrsrchd 1 day ago I just started on Urothilin A, is there interaction between the two as I have some MB but taking a break. Reply @nampmaljr9294 @nampmaljr9294 1 day ago Hey Lance, I'm 60 and my youngest child is 7. My goal is to make it to 100. I have no idea what I am doing, no idea where to start, and I have no idea how much to save up to do what I must do. My wife and I have considered moving to MX or Costa Rica (we all speak English and Spanish). How do I get in touch? Reply Lance Hitchings · 3 replies @DeeneMuada @DeeneMuada 3 days ago the effects are noticable and i wish it could go on forever but when it stops i get inflammed hairfollicles Reply @danwagner6235 @danwagner6235 3 days ago Hi, how do you all take your Methylene blue? My teeth looks very bad after a few months of taking MB. 1 Reply 4 replies @TomHimanen @TomHimanen 1 day ago Is alcohol suitable base for MB solution or should it be water based such as sterile water or even bac water? Or DMSO? Reply Lance Hitchings · 2 replies @lynnfarley7859 @lynnfarley7859 1 day ago Im is so cal. Got an iv of mb for lyme. It was $250. Bought 7 grams for $70. I did notice the mental clarity. The lyme issue little harder to tell. Reply @robertmcghee3646 @robertmcghee3646 15 hours ago Whats the best way to take this without turning into a smurf? Reply @petercottam7906 @petercottam7906 6 hours ago Anyone have any thoughts on.. when i have full of animal products futs n the like, my pee is blue to a green. When i do weeks of raw eating i have no blue or green pee. FYI MB has changed my life for the better. 😊 Reply @robertlennie7466 @robertlennie7466 3 days ago (edited) Extraordinary claims require extraordinary evidence as Carl Sagan said. Where is the evidence? Where are the human studies especially on efficacy and long term safety? Reply Lance Hitchings · 1 reply @bill9989 @bill9989 3 days ago I'm going to be cruel. I am very interested in anti aging primarily because I am old. So I'm looking for evidence that these things work. Lance does not look like he's holding back the clock. He has YouTubes going back as far as four years ago (I can't find any older ones). From then till now, Lance appears to be aging just as much as one would expect. For the record, so am I. Also, that billionaire that is doing that full immersion anti aging program doesn't look like it's successful. Look beyond his dyed hair and cosmetic surgery and it's pretty disappointing. But, for me, it's all moot. My hourglass is pretty much depleted. 1 Reply Lance Hitchings · 10 replies @mrkevinj @mrkevinj 1 day ago Where do you buy your MB from? Reply @davidg.johnson7574 @davidg.johnson7574 3 days ago So many possible side effects and so much room for making mistakes when taking methylene blue making it detrimental to the body. There are a lot more nutrients that aide the motochondria without taking this substance. I am sure that newer discoveries to fix the mitochondria without serious side effects are on the way. Eating right, maintain a good weight and exercise has always helped the mitochondria. 2 Reply 2 replies @dannyphillips7573 @dannyphillips7573 2 days ago Wow, did I catch hell for posting this on a Facebook longevity group Some medical official claimed it was just a dye, and it was a carcinogenic, and it would kill you But that said, where can I buy this? Reply @a.macdonald4877 @a.macdonald4877 2 days ago I waited for this one. Reply @WarmWeatherGuy @WarmWeatherGuy 2 days ago Lance, you're missing the link to your video about glynac you mentioned at 9:06. Reply Lance Hitchings · 1 reply @sameenaazeez8716 @sameenaazeez8716 22 hours ago How to use it on skin?? Reply @pjaworek6793 @pjaworek6793 1 day ago Most exciting thing that for some reason I don't have yet, stores!!! Time to get it the way I got fisetin Reply @jennifermccullough775 @jennifermccullough775 3 days ago Well is it ok to take it if your own antidepressants Reply Lance Hitchings · 1 reply @Vegasflatout @Vegasflatout 3 days ago What about hydrogen and meletonin. 1 Reply 2 replies @nickb1868 @nickb1868 3 days ago P.s. you are being ripped off in the states. In Europe 1% USP MB is around £10/$12 for 100ml Reply Lance Hitchings · 6 replies @johnvogt621 @johnvogt621 3 days ago It tastes bad. Anyone come up with a pleasant way to take the recommended dosage? 3 Reply 5 replies @jimwood1062 @jimwood1062 2 days ago Great explanation, but I feel the dosage discussion is way to excessive Reply Lance Hitchings · 2 replies @bobb.6393 @bobb.6393 3 days ago Love is blue 2 Reply @logical_lb3059 @logical_lb3059 2 days ago You’re taking way too much. It’s a hormetic agent Reply @reidbounsall9098 @reidbounsall9098 2 days ago Too bad you removed my comment about dosages. Your recommendations are WAY too high and will cause people to be spending ridiculous amounts of money unnecessarily. Shame on you, buddy! People need the truth! Reply Lance Hitchings · 3 replies @halamakhour2501 @halamakhour2501 1 day ago Businesss Reply @jacquelinewenceslao4539 @jacquelinewenceslao4539 2 days ago thanksdoc Reply Methylene Blue: A Revolutionary Anti-Aging Molecule? [Study 202] Physionic 144K subscribers Subscribe 3.1K Share Download Thanks Clip 61K views 3 months ago #methyleneblue #antiagingremedy #antiaging JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT] Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro … 605 Comments rongmaw lin Add a comment... @Physionic Pinned by Physionic @Physionic 3 months ago Methylene Blue is exciting for the reasons mentioned, but the data is lacking. If you have had personal experiences using it, I'd like to hear your experience. 69 Reply 54 replies @hendy24 @hendy24 3 months ago I've never been a fan of blue, so I just take the Meth part. Really boosts my energy 205 Physionic Reply Physionic · 9 replies @FoeverDirt @FoeverDirt 3 months ago I learned of MB through this video and went down the rabbit hole. I got really sick a few years ago and have dealt with symptoms (pain, brain fog, etc) since. I've tried many different supplememts to varrying effect but nothing ever took my symptoms away. I figured, what the hell do i got to lose and ordered some of this a few days ago. Oh my god... I have never felt more profound relief in my life. Literally EVERYTHING went away within just a couple hours. This is just my anecdote, but wow has this been a god send. Thank you for putting me on to this stuff. 56 Reply 12 replies @lloovvaallee @lloovvaallee 3 months ago When I was a kid I kept tropical fish as a hobby. Methylene Blue was ofren used as a sort of cure all for fish diseases. This was 50 years ago, so apparently at least some people knew about it before now. 69 Reply 7 replies @AlphaMale_1 @AlphaMale_1 3 months ago I'm 63, and as kids, we played with methylene blue in our chemistry sets. It was also used as a dye for making cell walls to improve microscope 🔬 viewing. 60 Physionic Reply 4 replies @HansLemurson @HansLemurson 3 months ago Important note: do not confuse ROS (reactive oxygen species) with ROUS (rodents of unusual size). Methylene Blue only has protective effects against one of them. 25 Reply 4 replies @airatru @airatru 3 months ago Been using MB for a few months with my wife, it helps a lot in dealing with stress and ptsr. I'm using 10 drops per day deluted in water, with taurine. It starts working within 5-10 minutes. At some point I thought to substitute bulletproof coffee with MB, but ended up doing both =) Some people suggest doing MB interveinly, but I'm not apt for it yet. I've noticed that I can run like in my childhood, without any thought of getting tired at least for some time (I'm around 40yo). But you'd better be careful, sudden bursts in stamina could be tricky - I've hurt my legs, and it took me 2 weeks to recover. 38 Reply 2 replies @DrFunFong @DrFunFong 3 months ago Methylene Blue has had a relatively menial role in medicine up until this time. It has been used as a practical liquid dye to detect fluid movement in some situations (primarily to detect fistulae, etc.). It also is used to demonstrate communication between different anatomic spaces for surgical applications. Methylene Blue is also used to treat clinically significant methemoglobinemia. Prussian Blue is different, but comes to mind because at one time, I was the principal investigator for Prussian Blue (Radiogardase), an orphan drug, which is used for both Thallium and Radiocesium poisoning. It is a non-sequitur, but I reflexively think of Prussian Blue when I hear the term Methylene Blue.... :) 18 Reply @ARC_VR @ARC_VR 2 months ago My experience was the first time I took it was before bed. 10 drops in 250ml of water. I slept well but when I woke up I felt very in control of getting up at any time I wished. I normally set my alarm on snooze but didnt feel like I needed to as I was tired but somehow alert. I noticed a couple other things. I dont normally think about it but I woke up with a sense of smell. I could smell and hear things I don't normally notice on my waking up and walk commute. Was very interesting. 9 Reply @bobmciver6437 @bobmciver6437 3 months ago At 71,definitely think it is worth taking...anything that improves redox in the electron transport chain gets my vote.I take 15 mg every other day (having experimented with several dosing strategies).Helps with sustainable energy all day long and a feeling of resilience (yes,resilience is such a nebulous term - but best fit). 36 Reply 9 replies @viperdna63 @viperdna63 3 months ago (edited) Thanks, Nick! Isn't there some solid data on using MB for malaria and for cyanide poisoning? I hope you can expand on it. I've been taking it orally for about 3 months. At 60 years old, it is giving me sustained energy. Also do red-light therapy and heard that's a good combo... 11 Reply @jameslaver6970 @jameslaver6970 3 months ago Been taking it since the beginning of Covid. Not sure if it was the reason I didn't catch Covid but but the rest of my family (4 others) all caught it. Other than that I noticed it gives me a slight energy kick. It also improved my long distance eye sight such that I don't need to wear glasses when driving. Hasn't done much for my close up vision but has helped with eye strain to some extent. It seems to have also helped my teeth as well. I don't seem to be getting plaque like I used to, 16 Reply 5 replies @patriciaferraro4189 @patriciaferraro4189 3 months ago (edited) I was given MB last year by a pharmacist while vacationing in South America. I had a UTI and it was a Sunday morning so I couldn’t find a doctor in the small town I was visiting before I had to catch a flight back next morning. It definitely resolved the symptoms - probably faster than some antibiotics. It didn’t clear the infection but it gave me a chance to make it back home comfortably and then arrange to see my doctor a few days later for antibiotics. That being said, I didn’t notice a remarkable improvement in energy but, between the uti and jet lag, I wasn’t feeling nearly as crappy as one would expect… 🧐 35 Reply 6 replies @iulianaa2079 @iulianaa2079 3 months ago In our neck of the woods, when I was a small child - 40 years ago, Eastern Europe - the doctors used it against throat infections. 14 Reply @genesmith3582 @genesmith3582 3 months ago nice topic. I experimented with it (USP grade) for a few years because of a history of chronic insomnia and a concussion. Didn't notice any surface-level benefits but it consistently brought my mildly elevated creatinine and BUN back into normal range. This was transient for a couple months maybe before they would go back up. Dose didn't seem to matter, either. I was testing 100 micrograms to 15-20mg. 11 Reply @stuartmalin661 @stuartmalin661 2 months ago I have been taking 10 drops in a glass of water, daily, for about 6 weeks. I find it to be fantastic. I have more focus and energy, yet no feeling of buzz or rush. I do believe that this works at the level of the MItochondria, and not by direct stimulation of hormonal pathways. Strong mitochondria are crucial. MB can play several different roles in the Electron Transport Chain. 5 Reply 1 reply @LightningBoltJpS @LightningBoltJpS 3 months ago A video about Methylene Blue’s history as an Emergency Room treatment/remedy would be interesting. I’m very curious as to how people figured out they could drink it safely, and I’m not sure what the true ER history is, whether there is truly an old saying: “When you don’t know what else to do, Methylene Blue” but I’ve seen in several places that MB has been mainstay of U.S. ERs for more than 100 years, which if true is pretty interesting considering it’s medical properties haven’t been closely studied. Do a video on all of that! 6 Reply 1 reply @tex7458 @tex7458 3 months ago hey Nicolas, first of all, I'm so happy to see your channel blow up! You definitely deserve it, great content. Secondly, I have sort of a request. If you're planning to make more videos about methylene blue, could you please also explain how and why does it somehow interfere with SSRI's? I really wanted to try it out, however I'm on Escitalopram and taking MB could have fatal consequences, at least that's what I read. I'd be very interested in your explanation about how these two drugs interact in a deadly way. Thanks! 15 Reply 1 reply @dbozzi52 @dbozzi52 3 months ago My father a physician would have us put a little methylene blue on mouth ulcers. They healed quickly. 12 Reply @Paxlee63 @Paxlee63 3 months ago I'm 60 and I started taking 2 drops in a glass of OJ in the morning a month ago and it felt like my brain fog was lifting, my memory recall for words definitely improved somewhat. I switched to taking it before I go to bed and my broken sleep has completely stopped. For the last week, I have slept right through until morning, something that hasn't happened in years. (I can usually get the odd night in without waking up once, but a whole week in a row was unheard of.) I ordered the MB skin products and have been using them for a week - yesterday I had 2 people comment on how good my skin is looking but that could be because I'm also getting proper sleep now. (I've read that when you mix it with OJ it stops staining your teeth blue. So far, so good. Note: I have been taking Vit C every day for the past 3 years, so it's not the Vit C in the OJ.) 15 Reply Physionic · 4 replies @user-zd6ow2gt7i @user-zd6ow2gt7i 3 months ago In the 80's in Romania, when we were little and got sore throats mom painted us with MB in the throat on the mangles. The bottle of MB was bought at the pharmacy as medicine as the first step against sore throat in case of colds. 32 Reply 5 replies @nickflynn666 @nickflynn666 3 months ago (edited) I remember in the Reservetrol controversy hearing that some of the beneficial effects falsely attributed to Reservetrol were instead caused by the dye used in the experiments. out of curiosity, was the dye Methylene Blue? 41 Reply 18 replies @jcornell7993 @jcornell7993 3 months ago I'm taking a microbiology class right now, and we use Methylene Blue to stain bacteria. I saw the the title of this video, and was like "Why are you drinking bacterial dye"? Most of the dyes we use are labeled as poisons in our lab, so this was intriguing that people are using MB for anti-aging. 15 Reply 6 replies @Ellis-Tor @Ellis-Tor 3 months ago for one of the oldest compounds ever, dont you find it kind of curious that "we dont have enough research on it"? i bet if we dont have it at this point, then we never will, theres just no incentive to research a drug that is un-patentable, so it will be forever ignored by research from here on in favor of new patented drugs 22 Reply 3 replies @cryptomando @cryptomando 3 months ago My mom was in the ICU, her organs were shutting down, they put her in a MB IV 1x per day, it was truly amazing how she responded to it, the physicians were very impressed. She was suffering from hypotension. MB does in fact have clinical uses despite what YTer says. DYOR but in certain doses and circumstances it can be life saving wonder drug 4 Reply 2 replies @johnschmidt8440 @johnschmidt8440 3 months ago Within three days of starting meth blue, I had significant improvement in my very, very long covid. 49 Physionic Reply 29 replies @stephenwillis9571 @stephenwillis9571 3 months ago Thanks for covering this - if you're looking for anecdotes, there are plenty of threads on longecity going back 15 years or more. Also, you might be interested on the effect on progeria cells (not in vivo). "“We tried very hard to examine the effect of methylene blue on all known progeria symptoms within the cell. It seems that methylene blue rescues every affected structure within the cell. When we looked at the treated cells, it was hard to tell that they were progeria cells at all. It’s like magic.” ~ Dr Zheng-Mei Xiong If you fancy a simple experiment - put some 1% on you skin for an hour (it will come off!) - it was for me remarkably hydrating. 6 Reply 2 replies @Dodgerzden @Dodgerzden 3 months ago (edited) I took it for a couple of months because it's supposed to have neurological benefits. I'm in my 60s and I'm having a really difficult time with my short-term memory which is an unnerving experience. I think it was starting to help but I don't think I took it long enough. I also think I might have been taking too much and that is why I was having stomach pain. There is supposed to be a point where taking more rather than less is counterproductive. When I did stop, I was surprised that it took me 3 or 4 days to stop streaming green urine. 5 Reply 6 replies @markfischer3626 @markfischer3626 3 months ago Yes we should not jump to conclusions. We already have other molecules that perform the same functions that we know are safe. We have a slew of antioxidants glutathione being only one of many. We have the salvage pathway to vastly increase the recovery and reuse of NAD+ efficiently generated from NMN. We have AKG possibly the most efficient fuel for ATP. We have molecules like spermadine to protect DNA. Cyanidin and fucouidan to activate SIRT 6. Quercetin which perfoms many functions. Fisetin which when used correctly is a powerful senolytic. Many more. 6 Reply @1980mikeh @1980mikeh 3 months ago Unlike some of the antioxidants you mentioned MB is a single electron donor/acceptor. It has relatively stable semiquinone radicals. Flavins also act similarly. Benefits of MB vs flavins would depend on their redox potential, which I cannot recall offhand 6 Reply @micdargis @micdargis 3 months ago Please continue your work in understanding MB, it is the only molecule I have found that can free me from Adderall. with MB I can concentrate without the side effects of Adderall on my personality 10 Reply 3 replies @KAMMEDIALLC @KAMMEDIALLC 3 months ago We used it in surgery to see if the kidneys would perfuse and locate ureters. Also, it was considered an irritant for nervous tissue and we wouldn’t use it as a marking agent during neurosurgery. 3 Reply @davidwoods1622 @davidwoods1622 4 weeks ago @physionic I got pulled into using OneSkin the key ingredient being the OS-01 peptide. It was hawked by Dr. Sinclair on this podcast. Anyways, I was hoping to get your intuitive feeling on what would have better synergy. OS-01 with methylene blue, or 0S-01 with retinol A? Reply @officespaceredstapler2287 @officespaceredstapler2287 3 months ago I am sure it will come as no surprise to you Nick that the Stapler is a heavy meth user. Being a 1960's model stapler I have a lot of electron slippage I need to control. Seems to have subjectively helped with mental clarity to a degree. Blue is also used even today in hospital ER's to treat various forms of poisoning. My wife once had a bad reaction to an over the counter, rash and some difficulty breathing. A shot of meth and 30 seconds later she was fine and back to nagging me as usual. It also makes a phenomenal carpet, tongue and teeth stainer - The Stapler 10 Reply @nieuweabnormaal5869 @nieuweabnormaal5869 3 months ago I use it in combination with red light/ near infrared light therapy. Be prepared to get blue contaminations hared to remove. Like in the kitchen after spillen the water solution. Or in the toiliet, the blue haze. Cleaning can be started using ascorbid acid. That is the powder also sold as vitamin C. I have a bottle of that, and rubbing that on the blue surface typically removes the blue dye. 5 Reply @NanoNutrino @NanoNutrino 3 months ago (edited) Can you look into molecular hydrogen and the studies which talk about the health benefits, it apparently works at reducing ROS as well. 5 Reply @jasonseymour1970 @jasonseymour1970 3 months ago I learned recently that Methylene Blue can disrupt Nitric Oxide which is a very important molecule for heart health. Do you have any thoughts on that? 16 Reply 1 reply @jaytm2574 @jaytm2574 3 months ago I've only been using it for a short while, but the change is remarkable. I'm using a commerical medicinal dilution used to treat UTI's sold by Bjain pharmaceuticals in New Delhi. It does also increase my BP, which is the one bad side effect. It gives a tremendous boost in energy and cognitive ability from just a few drops in my morning coffee. Definitely the real deal. 8 Reply Physionic · 16 replies @kenhnsy @kenhnsy 3 months ago Thank you once again for a really comprehendible explanation for the person with one or two biology classes. I hope to thank you in person one day. I shall be the person with a bluish complexion. 4 Reply @smit816 @smit816 3 months ago Using this daily now, it does feel like an anti depressend. Overall mood and memory is better and really cant say if my overal health improved. Probadly, but the main effect is my memory and focus. 5 Reply @Stefan-yz5lr @Stefan-yz5lr 3 months ago What scared the hell out of me was seeing a picture of a cross sectioned brain where apparently methylene blue had dyed the whole brain a blueish tint. If I hadn't seen that I was probably going to order some to try. 7 Reply 3 replies @maxiomburrows2099 @maxiomburrows2099 3 months ago I have been doing MB for a month now and yes my urine is usually greenish, I also do other supplements so I can state that it alone is why I feel so much better. 7 Reply 2 replies @darkhorseman8263 @darkhorseman8263 3 weeks ago It's an electron acceptor, so it will help balance NADh to NAD+ ratio, but there are better alternatives. 1 Reply @paulhindle3961 @paulhindle3961 3 months ago (edited) I've been taking MB for 6 years at the 1mg/kg level (5mg/kg is considered max safe). Wonderful stuff, I mainly started taking it for brain and eye health but it is beneficial for many other things. 21 Reply 9 replies @DoYouWantTaBeFree @DoYouWantTaBeFree 3 months ago Would love to see a video on astaxanthin, specifically the brand Valasta and its unique delivery mechanism. 6 Reply @surajitgoswami1871 @surajitgoswami1871 3 months ago Thank you. Will try it! Also switched to Statins from Niacin based on your reading of the research, particularly when it is not expensive and I have a good cardiologist. 1 Reply 1 reply @markseagoe4488 @markseagoe4488 3 months ago It's really cool that you covered this! Thanks. 1 Reply @peachesncream40 @peachesncream40 1 month ago (edited) C60 neutralizes ROS then resets and does it again. I'd be interested to get your analysis of C60 on health. There is a lot of research being done with C60. Reply 1 reply @openpalmclosedfist2282 @openpalmclosedfist2282 2 months ago (edited) I took too much of this over a month. I can say be careful on its effects on dopamine and serotonin. Im a very chill person, but the overdose of blue made me snap in the smallest things. Reply @SilverFan21k @SilverFan21k 2 months ago Ty bro for covering Aging and Longevity. Im glad youre getting views and recognition. 1 Reply @redrubberball @redrubberball 2 months ago I've heard about some possible interactions with antidepressants. I admit, I haven't watched your video yet, so unsure if you've addressed this, but either way, maybe a good idea to sum that up here in the comments since those medications are so widely prescribed. Reply @kenhoover1639 @kenhoover1639 3 months ago Thank you for this exciting new information. forward to learning more as more research is done. Reply @musgrove1967 @musgrove1967 3 months ago Yes! Run advertisements and keep doing what you love. It’s not selling out, it is providing the means for growth. It would not sway my opinion about your work; your research is high quality. Just sell as much sponsorship as you can and survive. This is growing pains and it is good! 1 Reply @ms.amazed @ms.amazed 2 months ago There's not enough research on it or you just haven't taken the time to. It's almost like it's too good to be true so I'm looking forward to your next video where you found all the research that you needed to just let it be amazing. Actually it's been around a lot longer Reply @ChessMasterNate @ChessMasterNate 3 months ago (edited) I use Methylene Blue for my computer water cooling system. Looks good, it's cheap, minimally toxic, and keeps stuff from growing in there. My sister drank a gulp of the normal computer water cooling stuff. That gave me a big scare, we induced vomiting, and she was fine, so I came up with this alternative. I have used it 7/24 for 4 years without any trouble. I just add a little water every 6 months. I originally bought it in mid 2017 to see if it was any good for bullet chess. And like 100 other things, it did not help. Only about 1 out of 10 things I tried helped. Nootropics are mostly just things that make you feel smarter, rather than perform better. I want my brain to work for a long time, so I never tried anything like amphetamines. And I know of chessplayers that did use amphetamines. Generally they burn out within 3 years. Then they are just lousy at chess and have to get a new hobby, like watching fish in a fish tank. 2 Reply @rgilbar @rgilbar 3 months ago I believe it is also used in emergency rooms for CO (carbon monoxide) poisoning. 2 Reply @nuancematters @nuancematters 3 months ago I only learned of the existence of Methylene Blue a couple of weeks ago, through some channel called Nootropics or something like that. Anyway, in the comment section, the guy who posted the video answered someone's question...the person had asked if there are any other supplements that should not be taken whilst taking meth blue...he said CoQ10 should be avoided (and another couple, which I do not remember). Do you know why this may be? 9 Reply Physionic · 7 replies @aclearlight @aclearlight 2 months ago Fun fact; if you take a clinically-relevant dose of this stuff, your pee will still have a blue tinge to it three days later. That weirded me out enough to judge this molecule too exogenous to mess with. Reply @JeremyHerbert @JeremyHerbert 2 months ago This sounds familiar, pretty sure I used it for my tropical fish when they were sick...30 years later I'm sure those fish are still alive today somewhere. 1 Reply @robertterkola5794 @robertterkola5794 3 months ago MB has also been used against brain fog due to neurological adverse effects of chemo. 3 Reply @tomanderson6140 @tomanderson6140 3 months ago Fun fact: A "kicker," also called a side card, is a card in a poker hand that does not itself take part in determining the rank of the hand, but that may be used to break ties between hands of the same rank. It's an old gambling term. Now you know. 2 Reply @theatheistpaladin @theatheistpaladin 3 months ago I used MB for blood surgar control. Worked really good for a bit, but at some point it stopped working. It made me happy on level that delirious for me. Once it started to change my gut flora did the effect wore off. So I no longer use it. 2 Reply 1 reply @Holy.HannaH @Holy.HannaH 3 months ago My sister was taking this, not sure if she still is. I was using a lot of other antioxidants but now Im thinking I might give this a shot. 3 Reply 2 replies @alex-craft @alex-craft 3 months ago As anti oxidant, its nonorganic molecule also should be way smaller than organic vitamin c or e molecules, so you may need it in much less mass to get same effect. Reply 2 replies @mariedenoyer2173 @mariedenoyer2173 3 months ago How can you tease us so with methylene blue and not give us some cookies and crumbs and hope that this could help us! Please keep us posted with any further info. 😊 1 Reply 1 reply @izidorkogovsek7417 @izidorkogovsek7417 3 months ago I am talking mb for two months now. My athletic performance has significantly improved. Much more than with creatine or any other supplement. 5 Reply @gaurangpatkar1695 @gaurangpatkar1695 3 months ago (edited) Overall is great medicine unless you are looking to have kids. Please if you could also include how it effects male fertility in next video it would be very helpful. 1 Reply @detritic @detritic 3 months ago As someone who is familiar with this from dyeing fungi for microscopy, this is really, really weird 2 Physionic Reply 1 reply @neferiusnexus @neferiusnexus 3 months ago (edited) "it feels like this topic came to me from the depths of the internet" ...what can I say except you're welcome. But yea, the reason Methylene Blue acts like an antidepressant completely unlike other antioxidants which are for the most part sedative is because at initial high concentrations it's actually pro-oxidative. Quite powerfully so. It'll dry out the skin around your mouth after you apply a ml to the back of your throat (common sore throat treatment). So initially it prompts the body to produce more of its own antioxidants... then becomes a net antioxidant when it eventually dilutes. It's so powerful that it used to be used as a treatment for cyanide poisoning. 2 Reply @Whatisthisstupidfinghandle @Whatisthisstupidfinghandle 3 months ago (edited) 7:30 When ROS interacts with fatty deposits in your skin it rusts them. Same process as what happens to a banana when it turns brown. That’s what those brown aging spots are. You are rusting. And if the rust is showing up on the outside, wait until you see the inside ! 2 Reply @Zuckerpuppekopf @Zuckerpuppekopf 3 months ago I only know it as a dye used in cancer detection, and it is used routinely for that. Esp oral cancer detection. Had no clue it was used for direct systemic effects by anyone. 1 Reply @melznutz3313 @melznutz3313 3 months ago Thanks, i just started low dose MB. It literally makes me happy 🌞 7 Physionic Reply @jamesslack8933 @jamesslack8933 3 months ago What I have seen no one address is whether it affects the gut biome adversely. Isn't this kind of an obvious question ❓ 8 Reply @m4inline @m4inline 2 months ago Just to afd that i have been using this a while now and i feel it worth saying that thr dose has to be kept low as from time to time depending on what food lr drink i consume i can get some pretty freaky side effects. Weird taste. Gym performance is insane...no pain no tiredness but less growth. Sometime blood pressure spikes. Anxiety. Etc Reply 1 reply @m4inline @m4inline 3 months ago Jesse Pinkman and Walter White invented Methylene Blue. From what I can tell the energy boost you get is like next level. 9 Physionic Reply Physionic · 1 reply @debbiejac @debbiejac 3 months ago We used methylene blue in radiological imaging as a substance that shows up under infrared. Injecting it into a milk duct in the breast allows that duct to show up under IR in surgery and be removed. Is this the same methylene blue?? 2 Reply @johnsposato5632 @johnsposato5632 2 months ago We used to use methylene blue as a histology stain back in h.s. and college. Is this the same molecule? Reply @g33k37 @g33k37 3 months ago Methylene blue is one of those things that interests me but toxity threshold and potential drug interactions scare the living daylights out of me 2 Reply @ttuanmu @ttuanmu 3 months ago I have been trying to take this since I struggle with low energy. Even just one drop in the water sometimes irritate my stomach. I want to be able to get used to taking it so that I can increase it to about 5 -10 drops..... >_< 2 Reply @jameslowellblakenship2192 @jameslowellblakenship2192 2 months ago I'm on the kindergarten part of this. I like the way you explain this. Reply @Johnnysday @Johnnysday 3 months ago Your approach is amazing. Like. My best loved old Professors, for some reason everything you say gets etched into my brain. 1 Reply @donwinston @donwinston 3 months ago This stuff is used in fish aquariums to prevent diseases. 6 Reply @Mojo_DK @Mojo_DK 1 month ago (edited) I have a question...Curcumin inhibits ATP-synthase to reduce the number of ATP molecules, and that is supposed to be good. Doesn't Methylene Blue do the exact opposite by supporting ATP-synthase? Why are they both good? 1 Reply 1 reply @incognitotorpedo42 @incognitotorpedo42 3 months ago The leuco form of methylene blue has been looked at as an Alzheimer's treatment. I don't know where it stands today; haven't looked in a few years. 1 Reply @jimdandy8996 @jimdandy8996 3 months ago So if you ingest Methylene Blue with some frequency, do you run the risk of your mitochondria becoming physiologically dependent on Methylene Blue? 4 Reply 3 replies @TheTrock121 @TheTrock121 3 months ago I'm guessing the need for extra electrons also explains why Grounding is helpful. Reply @lindaabernathy4876 @lindaabernathy4876 3 months ago I assume that you have checked out Dr. Francisco Gonzalez-Lima's publications. Very interesting. His lowest doses tested were 0.5 mg/KG body weight. That's a pretty high dose for daily use in my opinion. (Remove any stains with ascorbic acid). 1 Reply 3 replies @CJWass09 @CJWass09 3 months ago I've read that the free radical theory of aging is not accurate. There are conflicting results showing that under certain circumstances an abundance of cellular damage and ROS promotes longevity. 1 Reply @BakamonNO @BakamonNO 3 months ago Exciting. It's made from synthesized Smurfs blood incase you didn't watch the video 166 Physionic Reply Physionic · 24 replies @szymonbaranowski8184 @szymonbaranowski8184 3 months ago i want to know how it affects cancer cells. if it protects from apoptosis it could prevent also kills cells that you want to die. ofc it may help more, through this letting body actually be more capable to defend better Reply @insanityvault4481 @insanityvault4481 3 months ago I'll have to dig into it, but I remember MB being related to radiation, as in taking to help stop radiation poisoning 1 Reply @rm367 @rm367 3 months ago Just watched something regarding methylene blue a few months back. Interviewed was the founder of bluelene, a scientist Reply @LordVictorHalgaard @LordVictorHalgaard 3 months ago Important side effect to remember is Methyline Blue reduces Nitric Oxide; low Nitric Oxide is a major marker of aging, and causes Erectile Dysfunction - One of the few current official uses of Methylene Blue is in fact to stop prolonged unwanted erections. 2 Reply 5 replies @billshuey7422 @billshuey7422 3 months ago We stocked it in the hospital for cyanide poisoning, however, it was never used😅 1 Reply @ddextera @ddextera 3 months ago IL-11 looks pretty interesting. Would like to hear your take on the research recently presented by Dr Cook. 1 Reply @JTS616 @JTS616 3 months ago (edited) When you say there isn’t much clinical data, do you mean specifically to anti aging? It’s been used as a pharmaceutical for over a century & is on the WHO’s list of essential medicines. I think the Rx name is like provalBlue or something like that 1 Reply Physionic · 1 reply @isse6790 @isse6790 3 months ago Worth mentioning that it dyes your brain and turns it blue. 9 Reply 2 replies @victorbaez3688 @victorbaez3688 3 months ago 45 years ago we used it to cure our litle fishes, amazing we droped a litle MB in their water, it turned torally blue and they relived again. 6 Reply 1 reply @annemyashea @annemyashea 3 months ago I saw a video on YouTube about it. I googled it & decided against it because of the side effects. 1 Reply @indridcold4210 @indridcold4210 3 months ago I always thought it was supposed to be healthy because it was a scavenger of excess ammonia and nitrite in the bloodstream. Reply @_chimera_ @_chimera_ 2 months ago Considering the amount of atp production how much of that blue one would need to consume to make any difference? Seems like a lot Reply @krix0043 @krix0043 2 months ago i take MB with ascorbic acid since 2018 and still love it 1 Reply @abominabelle @abominabelle 3 months ago (edited) I just checked (extremes in) the prices. The same substance for technical use: 3,99 euro. Branded as potential "magical": medicine 46,26 euro for 1% solution. 1 Reply 1 reply @alex-craft @alex-craft 3 months ago It also may help with urinary tract infections. 1 Reply @LaidBackPedalPusher @LaidBackPedalPusher 3 months ago We used methylene blue to cure fungus on fish in our aquariums. 3 Reply @whatthefunction9140 @whatthefunction9140 2 months ago Been taking 5 drops twice a day. Not sure i would want to live without it. Cured my life long cronic fatigue 2 Reply 1 reply @jamesaron1967 @jamesaron1967 3 months ago People are taking MB as a nootropic. Any info on using this for that purpose? Reply @akaimon3 @akaimon3 3 months ago (edited) In surgery MB would be used to mark cancer cells often in breast cancer surgery, lymph node tail marker as well in radical breast mastectomy 1 Reply @Xanderpr96 @Xanderpr96 3 months ago Can you make a video on the new aspertame paper in mice linking it to slower mental activity? Reply @jmc8076 @jmc8076 3 months ago I try to stay away from dyes in gen based on studies to date but stay open minded. Interesting. Thx. Reply @JasonCummer @JasonCummer 3 months ago The LD50 is 1180mgkg rat, vs vit c 11900mg rat. Can you speak to that at all. Its an order of magnitude more deadly... but I would love to learn more about what this is in context Reply @discokillers8674 @discokillers8674 1 month ago Helps in stroke recovery as well. Reply @kkut4867 @kkut4867 2 months ago You don't look a day over 78... good work my man! 1 Physionic Reply Physionic · 1 reply @MarufoVega @MarufoVega 3 months ago (edited) when I was a kid I often used methylene blue to treat a tank of tropical fish that had some fungus ick 4 Reply @JacquesTreehorn @JacquesTreehorn 3 months ago (edited) I tried it for a while. 5 or 6 drops in my smoothy once a day in the morning. It dyed my brain blue and ketchup started tasting strange. I discontinued it because of the ketchup thing. 4 Reply 7 replies @833tr00t @833tr00t 3 months ago There have to be downsides to this stuff, it's just too good to be true... 3 Reply 4 replies @unreasonable4rce @unreasonable4rce 2 months ago (edited) I find that I get lower gut pain when taking MB. Only took 5 drops in the morning and five drops in the evening. Pharmaceutical grade. 0.1%. When I stop taking it the pain fades away after a few days. I’m wondering if it kills gut microbiome. When I pluck up courage I might try again, maybe just 2 drops in the morning. Reply @mikesymth7243 @mikesymth7243 3 months ago If you apply MB to the skin it will turn your skin blue. but will fade in a couple of days. 2 Reply @lewynld @lewynld 3 months ago There is significant anecdotal evidence passed down about benefits and hazards, as chronicled in tangled up in blue, blue eyes crying in the rain, blue suede shoes, etc etc Reply @justingirard7476 @justingirard7476 3 months ago So the dark blue dye that absorbs light also absorbs light when ingested. And, (probably) when it reaches saturation, donates tha energy to other locations. I wonder what other materials do this lol. Can I just eat my gym shirt? Reply @scottg429 @scottg429 2 months ago I am getting bad herxheimer reactions from MB. Should I keep going and tough it out? Reply @masterspin7796 @masterspin7796 3 months ago 1-2 drops a day is all that I need to feel as good as I did at 25-30...@64 3 Reply @capgains @capgains 1 month ago I was hoping for more mental clarity but I’m fn brain dead. What a tragedy not being able to use the mind on command Reply @Rene-uz3eb @Rene-uz3eb 3 months ago (edited) Keeping my fish tank MB, and experiment some more. What about its antifungal properties? Reply @drironmom6815 @drironmom6815 2 months ago You said you’ll wait for the research to be done before deciding. Well, since most research is now funded by the pharmaceutical industry, and MB can’t be patented, I don’t think we’ll be seeing any research soon. I’m 67 and I don’t have time to wait. Im convinced enough and have been taking pharmaceutical grade MB 1% at 2 drops twice a day with red and near infrared light therapy. Reply @Angela-hd8ds @Angela-hd8ds 3 months ago Thank you for this video. I just have vitalia pharma solution use extern 1% liquid can i use this for my health?? Reply @kristijan8518 @kristijan8518 3 months ago Does methylene blue have any toxic effects though? Do we know how it interacts with other systems in the body? Reply 2 replies @jeremywright8612 @jeremywright8612 2 months ago I really like this dude, I like he's channel. Reply @Zach0451 @Zach0451 3 months ago If it's good enough to bathe my goldfish in, then its good enough for me to drink a gallon 16 Reply Physionic · 3 replies @amandathomas4115 @amandathomas4115 3 months ago Isn't methylene blue derived from the leaves of the indigofera tinctoria plant..? Reply @robertmcpherson7939 @robertmcpherson7939 3 months ago Good report. thank you. Reply @JackMyersPhotography @JackMyersPhotography 3 months ago Much like the first person to ever actually consider eating a durian fruit, who was the first person that decided dye was something worth ingesting for better health? Reply Physionic · 2 replies @khamen723 @khamen723 2 months ago I’ve been drinking Selsun Blue since the early 80’s 😂 Reply @mileaux2314 @mileaux2314 2 months ago if i was to apply this to my skin would i need to worry about dosage or do you only need to be concerned for oral/intravenous administration Reply 2 replies @JeffHoneyager @JeffHoneyager 3 months ago I purchase MB and have ingested it. I now have telekinesis and can teleport around the globe - just kidding. The only real thing I have experienced is to pee blue for about a day. 3 Reply Physionic · 1 reply @elaine3310 @elaine3310 3 months ago Great information, though the noise that sounded like possibly a dog scratching was very distractive.... Reply @yasin10yasin @yasin10yasin 2 months ago I like your way to explain Physionic Reply Physionic · 1 reply @gordonwho @gordonwho 3 months ago I just used it in my fish tank! 1 Reply @skyrask1948 @skyrask1948 3 months ago If it is so good at blocking UV does it impede vitamin D production? 3 Reply Physionic · 3 replies @HulkSmash315 @HulkSmash315 3 months ago I think I'll wait for more research on it. 1 Reply 1 reply @Elaba_ @Elaba_ 3 months ago I have used it for decades and everybody calls me Levi's nowadays. I don't understand why. 1 Reply @thomaslevine405 @thomaslevine405 3 months ago I used it in my fishtanks years ago. 4 Reply @Foxynaut888 @Foxynaut888 2 months ago I take 10 drops daily. The difference is night and day. Reply @happyjourney8675 @happyjourney8675 3 months ago I've heard methylene blue inhibits nitric oxide production. 4 Reply Physionic · 5 replies @liamtaylor4955 @liamtaylor4955 3 months ago Make it widely available, to all 8 billion of us! :) Reply @michaelfreytag8134 @michaelfreytag8134 3 months ago Love your videos sir but don’t need to get cutesy with the editing. Keep producing your videos ! Reply @dort5436 @dort5436 3 months ago You're young! I don't have ten to twenty years to find out what study results are. I take MB on and off. 1 Reply 1 reply @AndDiracisHisProphet @AndDiracisHisProphet 3 months ago I just finished a rewatch of Breaking Bad. What a coincidence... Reply @SquatFull @SquatFull 3 months ago (edited) Thanks for the basic review of the mitochondria. Mitochondria are not proteins in the cell. They are an organelle in the cell. What you call the electron slippage is named the Electron Transport Chain in textbooks on metabolism. Is there a Meta-analysis of Methylene Blue? If not, you are just reviewing a study. Reply @Motorhead1 @Motorhead1 3 months ago (edited) Dr Sinclair at Harvard School of Medicine had genetic reseach halting the aging " switch" in animals . Maybe do a follow up. Does Methylene blue survive stomach acid ? 4 Reply Physionic · 2 replies @robertmckay2274 @robertmckay2274 3 months ago Jeez man. The Jack in the box effects with sound effects are really hard to endure predicting and then, enduring. Really difficult probably even for neurotypical I'd bet. Try another fade. (Not the swirling one DeLauer uses now and then either! Am I too sensitive yes I am. Reply @Burnrate @Burnrate 3 months ago So we just need to get better at our quantum interactions and aging will stop. 1 Reply 1 reply @dianetheone4059 @dianetheone4059 3 months ago (edited) Would eating old blue paint be similar? Or probably a topical application. What is this magic dye that contains Methylene Blue? Reply @user-yl7kl7sl1g @user-yl7kl7sl1g 3 months ago You look great for eighty eight years old. I'm shocked. 1 Reply Physionic · 1 reply @seranonable @seranonable 3 months ago My cat is named Cheeseburger and when you said "Cheeseburgers!" she looked up from her paw grooming 6 Reply @Inventeeering @Inventeeering 3 months ago This speaker is to extreme. Humans evolved as omnivores, not carnivores. One more point, humans are evolutionarily adapted, not designed. Reply 1 reply @nickjames3049 @nickjames3049 2 months ago What about the nitric oxide inhibiting action!? Not a desirable side affect. 🤔 2 Reply @stephencarlsbad @stephencarlsbad 2 months ago If its lypophilic then shouldnt pass through the skin well if it passes through the fat barriers? Reply @NotMolly-jf2rh @NotMolly-jf2rh 3 months ago I just took my first dose. Skeptical! Reply @gtpoore @gtpoore 2 weeks ago (edited) wondering why all these video's on MB never mention that it is a NO2 inhibitor. Pretty important detail to leave out don't you think? Also important is that you don't want to take this if you are on anti-depressants. That Includes Lithium Orotate! Don't just watch video's on this. Dig deeper. 1 Reply 1 reply @prdeacon974 @prdeacon974 2 months ago I take almost daily. But have no clue if AM or PM or if empty stomach or with food. So I just randomize it. Reply @redberries8039 @redberries8039 3 months ago I may be jaded, but since MB is cheap to make and can't be patented at this point - i expect obsfucation from pharma 9 Reply 2 replies @ms.amazed @ms.amazed 2 months ago What vitamin c vitamin A are you talking about would that be the synthetic kind or the kind that our body makes I mean cuz there's a real big difference here I think we should probably let the people know that Reply @joeputz3 @joeputz3 1 day ago I have tried this and absolutely get no energy at all from it. I think there are benefits for detoxification but energy. Not me. Reply @rejiequimiguing3739 @rejiequimiguing3739 3 months ago But does it makes intestinal worms blue skin? Reply @teddybearroosevelt1847 @teddybearroosevelt1847 2 weeks ago I’ve heard your teeth turn blue from it though and that it can cause horrible stains 1 Reply @leunam3434 @leunam3434 3 months ago Used to neutralize cyanide gas poisoning. Reply @kathleennorton7913 @kathleennorton7913 1 month ago (edited) How do you get it? Can pets take it? Reply @michael-qp9xd @michael-qp9xd 3 months ago U mention is a antioxidant just like vitamin c and so not good as want oxidants like from exercise and these cause body to make protective compounds intrinsically so body gets stronger. Think too u reported on this in other videos. So this methylene blue could be big issue as u mention. Weird why some would jump ahead of more testing and start taking. Think better to take chance with drug like rapamycin for slowing aging. Reply @thisbee66 @thisbee66 2 months ago Why is methylene blue and red dye bad? Reply @spamonme4328 @spamonme4328 3 months ago It has a weird side effect it turns your skin blue just Smurfy😂 Reply @susymay7831 @susymay7831 3 months ago What do you think about Brian Johnson's ideas and protocol? 2 Reply @williammartin9450 @williammartin9450 3 months ago I heard that David Sinclair just sold his stake in a Methylene Blue manufacturer to GSK for $1 billion! Reply 2 replies @oussamafilali6158 @oussamafilali6158 2 months ago I noticed an improvement in skin and an increase in hair growth. Who noticed this? Reply 1 reply @joeymcdonald8526 @joeymcdonald8526 2 months ago Do c60 next please Reply @paulpellico3797 @paulpellico3797 3 months ago welp...here it is.... i come here mostly for the science, and the science of studies break down. i see a few studies mentioned here, but i am afraid to go further without your usual deep dive of these studies. simply mentioning them and their findings without your dissecting them is simply not good enough. hopefully this IS a breakthrough supplement or drug. but as of right now, it feels sorta faddish. 1 Reply @descai10 @descai10 3 months ago That name sounds like it came straight out of a sci-fi film/novel Reply @toddboothbee1361 @toddboothbee1361 3 months ago How about a little Prussian blue instead? Reply @jpintero6330 @jpintero6330 3 months ago Renue Blue™ Face Cream with Methylene Blue, NAD⁺, NMN, NR (Liposomal) Reply @Goodelaw @Goodelaw 3 months ago I wish you had left the inappropriate joke in! Very interesting post. 2 Physionic Reply @garymason7463 @garymason7463 2 months ago MB eye drops. I’m thinking it might look cool funny and perhaps do some good. Any research? Reply @mdzialo @mdzialo 3 months ago It's been used for 140 years only, so check back with me in another 100 years when we have some data and I'll let you know, and by then maybe I'll have finished my degree, too. 1 Reply @danmarquez3971 @danmarquez3971 3 months ago If methylene blue works, then we know what to give future astronauts who travel the universe. They will become the future blue space aliens. LOL! Just kidding, or course... Reply @joerockhead7246 @joerockhead7246 3 months ago thank you. 3 Physionic Reply @jvlbme @jvlbme 3 months ago So where in the world can I buy this thing, and get something I can trust? Oh, and speaking of "where in the world", I'm in Sweden, if that matters. Anyone has any good tips? Reply 2 replies @design4leathercom739 @design4leathercom739 2 months ago lost me at the geek jokes🥴 Reply @Mau365PP @Mau365PP 3 months ago I tried it but it did nothing 😔 Reply @ramonoliveira1036 @ramonoliveira1036 2 months ago I can't find as a supplement anywhere. Reply @damien2198 @damien2198 3 months ago I was thinking of using it, but couldn't find it as pill, I am not willing to look like a blue tongue lizard ;-) Reply 2 replies @angelalee5838 @angelalee5838 3 months ago Andrew huberman just said he used to clean his fish tank with it Reply @Mattjki @Mattjki 2 months ago He doesn't look a day over 87. Reply Physionic · 1 reply @darinrmcclure @darinrmcclure 2 months ago Is Carbon 60 on your radar? 🖖😎 Reply @albertlwilcox @albertlwilcox 3 months ago Put it in grain party grape drink, then put a small sign in the bathroom letting them know that it that they are actually peeing 😂blue. Ha ha Reply @markmartin2292 @markmartin2292 3 months ago It can’t be patented so no money for research. 3 Reply 1 reply @isa-manuelaalbrecht2951 @isa-manuelaalbrecht2951 3 months ago NADH is equal to mb..😊 Reply 1 reply @ranchery @ranchery 3 months ago Jack Kruze suggest methylene blue IV in brain surgery Reply @SessleIsosceles @SessleIsosceles 3 months ago I LOVE supplementing MB, feels amazing 1 Reply @sikosis999 @sikosis999 3 months ago a buddy has been on it for a while, backed by doctor support and regular labs . . .i'm starting a regiment now. he has marked improvements in several areas we're hoping it does similar things for me . . . first two weeks of low dose then blood and we'll see . . . already pee'n green :) oh don't get it on anything. . it is a dye :) Reply @allurbase @allurbase 3 months ago What? I learned about methylene blue in high school for experiments, as a contrast. Reply @Zuckerpuppekopf @Zuckerpuppekopf 3 months ago It is still a dye. Systemic use would likely turn a person into one of the Na'vi of Avatar. Reply @booboobumbum6602 @booboobumbum6602 3 months ago It will never have enough clinical data - because its so cheap and nobody IE bg pharma - it's been used against malaria for years Reply @ericknea @ericknea 3 months ago is an old and still used chemical to desinfect water for aquarium Reply @irenemays6053 @irenemays6053 1 month ago You lost me at “not much data” ;) Reply @ElNietoPR @ElNietoPR 3 months ago Are you Blue Steeling in the thumbnail? Reply @user-vw8tl2wp9o @user-vw8tl2wp9o 3 months ago MB is an NO2 Antagonist, so soem feel it is not good long term Reply @brucehehehe @brucehehehe 3 months ago We all gonna be blue man group Reply @darcyfernandes8922 @darcyfernandes8922 3 months ago Good. 1 Physionic Reply @xiaonguyen6693 @xiaonguyen6693 3 months ago I really hate rusting Reply @travv88 @travv88 3 months ago 0:19 did you just say you're 88 years old? 1 Reply Physionic · 3 replies @unreasonable4rce @unreasonable4rce 2 months ago An ad at 1 minute? Really? 1 Reply @pierrejeanes @pierrejeanes 3 months ago 😮 Reply @Hoyt_twd @Hoyt_twd 3 months ago It's street name is "YOU." 1 Reply @handlez411 @handlez411 3 months ago Please tell us the joke :) Reply @rayvac7743 @rayvac7743 2 months ago What about the heavy metals not good. Reply @currentaf8455 @currentaf8455 3 months ago Walter white at it again. Reply @ZidaneTribal93 @ZidaneTribal93 3 months ago Wow 1 Reply @dk4366 @dk4366 3 weeks ago I just started taking this and now im blue da baa de dabba di da baa de dabba di 1 Reply 2 replies @IvanJankovicDC @IvanJankovicDC 3 months ago Lol, this kids, hasn't heard about Methylene Blue Reply Physionic · 1 reply @Johnnysday @Johnnysday 3 months ago You must reconsider a career in education. The University of Washington has a home for you… Reply @FrostDrive @FrostDrive 3 months ago cheeseburgers!! 😂😂 Reply @nobodynever7884 @nobodynever7884 1 month ago All I want to know is the innapropriate joke. Reply @iDerp69 @iDerp69 3 months ago You look suspiciously young for someone 88 years old 🤣 1 Reply Physionic · 1 reply @markmasterson4811 @markmasterson4811 6 days ago Interesting but your presentation style and jigging up and down ruins concentration on the details in this. Either put the visual up and build on it or leave it out entirely. That's the kicker. Reply @stephanygates6491 @stephanygates6491 3 months ago You say you're 88? Reply @Aegispsyche @Aegispsyche 2 months ago The beginning explanation is so far off. It's stated as fact but us not fact. There is a huge paradigm shift in science and what he reports about ATP amd etc is completely false as stated. Scary that his specialty is mitochondria research. Reply 1 reply @whiteninja9481 @whiteninja9481 3 months ago Dramatize. Reply @RoxannHuffman @RoxannHuffman 2 months ago Are you really 88? Reply @medicinefuture @medicinefuture 3 months ago Electrons do not cause oxidation, but in the contrarily electrons neutralize free radicals, 1 Reply @edword7195 @edword7195 3 months ago It was explained before that is anoying like ros from friends Reply @futurebabe8001 @futurebabe8001 3 months ago ... you're cute... 😊 Reply