mTOR ,mTOR Signaling Pathway: Regulation by the Lysosome

mTOR University of Rochester Biochemistry (Biol252) 6.64K subscribers Subscribe 258 Share Download Clip Save 23,642 views May 1, 2015 Submitted by Mishael Khan Key moments View all Transcript Follow along using the transcript. Show transcript University of Rochester Biochemistry (Biol252) 6.64K subscribers Videos About 4 Comments rongmaw lin Add a comment... @estebanvenegas89 @estebanvenegas89 6 years ago I'm from Chile! nice video, thanks for the information :) 3 Reply 1 reply @AlguienenElinternet @AlguienenElinternet 5 years ago Me too! Reply @spiralviper8158 @spiralviper8158 4 years ago (edited) The background music is strangely intriguing.. what's going on here? mTOR Pathway and its Regulation Hussain Biology 207K subscribers Join Subscribe 522 Share Download Thanks Clip Save 31,066 views Premiered Oct 29, 2020 CSIR Part C Topics Previous Video AKT/PKB Signalling Pathway : • PI3k/AKT/mTOR Pathway In this video we will be discussing about the mTOR Pathway. mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription.As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors.[12] mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton. mTOR Complex 1 (mTORC1) is composed of mTOR, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (mLST8) and the non-core components PRAS40 and DEPTOR.This complex functions as a nutrient/energy/redox sensor and controls protein synthesis.The activity, insulin, growth factors, phosphatidic acid, certain amino acids and their derivatives (e.g., l-leucine and β-hydroxy β-methylbutyric acid), mechanical stimuli, and oxidative stress.... Featured playlist 128 videos CSIR Part C Topics Hussain Biology Hussain Biology 207K subscribers Videos About 52 Comments rongmaw lin Add a comment... @CharitysClarity @CharitysClarity 2 months ago I can not believe how simple you made this considering it’s so complex to understand let along explain!! Bravo 👏thank you !! I wish you much success in your career 4 Hussain Biology Reply Hussain Biology · 1 reply @gem1632 @gem1632 3 years ago (edited) It takes massive amount of research to firstly understand this concept.. Then simplify it,is another challenge Then making such brilliant drawings is yet another big challenge And finally completing the video... Wow wow wow...this is huge amount of work u put in ..i guess to make this single video,atleast 7 to 10 days have to be spent... U R GREAT. .... 27 Hussain Biology Reply Hussain Biology · 1 reply @suckerpunchofficial1758 @suckerpunchofficial1758 3 years ago (edited) Hey thank you so much man! I am a Business major who is procrastinating and I don't take any biology classes but this really helped me understand it! 2 Hussain Biology Reply Hussain Biology · 1 reply @michaeleisenberg7867 @michaeleisenberg7867 3 years ago (edited) Hi Shabir! Another amazing and fascinating animation!!! I love it 😊💖💗. More lock and keys 🔓 🔑. Of course it just adds to my confusion 🤔 of how on earth 🌎🌏 did this happen? From elements to thousands of complicated and uniquely functioning polypeptides. But today I'd like to focus on my appreciation 💗 to you for reporting on these byzantine cellular processes and to the research scientists 🔬 in all the labs across the world who brilliantly decode and decipher these complex processes. It is beyond amazing that people like you and your peers can go in a lab, invent an experiment, and trace these polypeptide pathways down to which amino acid is phosphorylated and which part of the protein is then bent or twisted to achieve its purpose--allowing all of us to live--including my 2 English golden retrievers 🐕🐶 (Chuck & Bert). Bravo 👍👏👏🙌🙌!! 6 Reply Hussain Biology · 1 reply @deepakthakur7129 @deepakthakur7129 1 year ago (edited) You are awesome sir. Like always. And yu know what if people start watching yur video for 5-10 mints ..they can save their hours.and crack their PhD interviews whether it's iits in India or other colleges in abroad 1 Reply Hussain Biology · 1 reply @RehanKhanNISER @RehanKhanNISER 3 years ago (edited) Please keep making such video, never ever stop. 1 Hussain Biology Reply Hussain Biology · 1 reply @medicalbiochemistry_ @medicalbiochemistry_ 3 years ago (edited) Keep up the great work 2 Reply Hussain Biology · 1 reply @masharab2695 @masharab2695 3 years ago (edited) Would you plz make a video on (counter current exchange mechanism), one of the sub topic of regulatory function of kidney. I HOPE you will make a video for us. We will very thankful to you by heart and soul. 1 Reply Hussain Biology · 1 reply @measententia2154 @measententia2154 3 years ago (edited) Sir are you a single person behind your videos?? Is there anywone to help? Appreciate your hardwork..❤️ 3 Reply Hussain Biology · 2 replies @nathan-498 @nathan-498 2 years ago (edited) How does IGF-1 effect myostatin? Reply @a45sankhadiptoghosh64 @a45sankhadiptoghosh64 3 years ago (edited) Very hard concept , amazing 2 Reply Hussain Biology · 1 reply @krishnendukundu6446 @krishnendukundu6446 3 years ago (edited) Complex concepts..mess my brain...but kudos your efforts 🙏 2 Reply Hussain Biology · 1 reply @ImtiazAli-vm3gk @ImtiazAli-vm3gk 3 years ago (edited) Great sir 1 Reply @kaushikk4425 @kaushikk4425 3 years ago (edited) Thanks sir. Superb Reply Hussain Biology · 1 reply @akashpathak7182 @akashpathak7182 3 years ago (edited) Very good work 1 Reply Hussain Biology · 1 reply @priyakamboj5850 @priyakamboj5850 2 years ago (edited) Sir atni achii drawing kha sa sikhi h its really amazing style to show whole process thanks so. Much. 2 Reply Hussain Biology · 5 replies @sbb230 @sbb230 3 years ago (edited) Sir this video remain available latter??? 1 Reply Hussain Biology · 2 replies @useranonymous9274 @useranonymous9274 3 years ago (edited) Hussain are you a scientist? I feel like you make groundbreaking research in a lab somewhere. 2 Hussain Biology Reply Hussain Biology · 4 replies @nishatfatima2091 @nishatfatima2091 3 years ago (edited) Sukriya sukriya..... 1 Reply Hussain Biology · 1 reply @karakraft9190 @karakraft9190 2 years ago (edited) wHAT'S YOUR CHESS RATING? Reply @beautyblossoms1879 @beautyblossoms1879 1 year ago (edited) Are you from Kashmir? 1 Reply Hussain Biology · 2 replies mTOR Signaling Pathway: Regulation by the Lysosome JJ Medicine 934K subscribers Subscribe 984 Share Download Thanks Clip 43,814 views Jan 16, 2017 Biochemistry & Molecular Biology mTOR Signalling and Regulation by the Lysosome In this video, mTOR signaling is explained in a step-by-step powerpoint lesson. Regulation of mTOR signaling by the lysosome is also explained. Hey guys! In this video, I teach you about lysosomes and mTOR signalling and how lysosomes regulate mTOR signaling. Please let me know what you guys think. Any and all feedback is greatly appreciated! Subscribe for more free medical lessons / @jjmedicine ------------------------------------------------------------------------------------------------------------- For books and more information on these topics https://www.amazon.com/shop/jjmedicine Support future lessons (and get other cool stuff) ➜ / jjmedicine Follow me on Twitter! ➜ / jj_medicine Come join me on Facebook! ➜ / jj-medicine-100642648161192 Start your own website with BlueHost ➜ https://www.bluehost.com/track/jjmedi... Check out the best tool to help grow your YouTube channel (it’s helped me!) https://www.tubebuddy.com/jjmedicine ------------------------------------------------------------------------------------------------------------- Check out some of my other lessons. Medical Terminology - The Basics - Lesson 1: • Medical Terminology - The Basics - Le... Medical Terminology - Anatomical Terms: • Medical Terminology | Lesson 6 | Anat... Fatty Acid Synthesis Pathway: • Fatty Acid Synthesis Pathway: Overvie... Wnt/B Catenin Signaling Pathway: • Wnt/β-Catenin Signaling Pathway | Ove... Upper vs. Lower Motor Neuron Lesions: • Upper and Lower Motor Neuron Lesions ... Lesson on the Purine Synthesis and Salvage Pathway: • Purine Synthesis and Salvage Pathway Gastrulation | Formation of Germ Layers: • Gastrulation | Formation of Germ Laye... Introductory lesson on Autophagy (Macroautophagy): • Autophagy | Macroautophagy & Importan... Infectious Disease Playlist • Infectious Diseases Dermatology Playlist • Dermatology Pharmacology Playlist • Pharmacology Hematology Playlist • Hematology Rheumatology Playlist • Rheumatology Endocrinology Playlist • Endocrinology Nephrology Playlist • Nephrology ---------------------------------------------------------------------------------------------------- **MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition. ---------------------------------------------------------------------------------------------------- Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know. I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :) Thanks for watching! If you found this video helpful, please like and subscribe! JJ Key moments View all Featured playlist 73 videos Biochemistry & Molecular Biology JJ Medicine Transcript Follow along using the transcript. Show transcript JJ Medicine 934K subscribers Videos About 6:58 AMPK Signaling Pathway: Regulation and Downstream Effects by JJ Medicine 8:50 AKT Signaling Pathway | Regulation and Downstream Effects by JJ Medicine 18:38 mTOR Signaling Pathway: mTOR Complexes, Regulation and Downstream effects by JJ Medicine 15 Comments rongmaw lin Add a comment... @luisotaviomoreira5682 @luisotaviomoreira5682 6 years ago Thank you for making this awesome video! It was really helpful for me. I have one simple question: Can you tell us the bibliography of this video? It would be very appreciated. Thank you a lot! 3 Reply @ST-xd9ct @ST-xd9ct 3 years ago (edited) Thank you for making this video! Although I'm Japanese and not very good at listening to English, I could listen to you and understand review about mTOR that took me hours due to your clear explanation. わかりやすい説明でした。また、はっきりと話してくれたため日本人の僕でも聞き取ることができました。mTORに関してはreviewを読むだけでも大変だったので、この動画を見れて良かったです。ありがとうございました。 2 Reply @pedromaciel3058 @pedromaciel3058 3 years ago (edited) Your class is amazing! From where did you take this biochemistry information? 1 Reply @shutinghan6946 @shutinghan6946 6 years ago hello jj! Thanks a lot for this very helpful video ,may i ask what software did you used to make these demonstration pictures? 2 Reply @science_mbg @science_mbg 6 years ago I did not find your autophagy video but if you havent done it yet, please would you mind doing autophagy or mitophagy as well as akt/erk/pi3k pathway. Thanks a lot 2 Reply @robinhood4640 @robinhood4640 4 years ago (edited) I did laugh at 10.33 'it's kind of complicated" So up until then it was easy? It's all very complicated to me but extremely fascinating and informative. 6 Reply @taeyoonjung9857 @taeyoonjung9857 4 years ago (edited) Think you really explain it easily Thanks Reply @mahasaber424 @mahasaber424 4 years ago (edited) Great.Thank you. Reply @jimfife6255 @jimfife6255 1 year ago (edited) So, I think you're saying the amino acids liberated in the lysosome become nutrients, which keep the autophagy from running amok. Reply @ashburnconnecttv7860 @ashburnconnecttv7860 4 years ago (edited) Can mTOR inhibit growth factor–β (TGF-β) a major immunosuppressive cytokine? Reply @mrmeach1967 @mrmeach1967 3 years ago (edited) I guess I’ll be watching a lot of other videos since he says many times, “I’ll get to that in another video.” 👍🤔 3 Reply @krazyk500 @krazyk500 2 years ago (edited) Me a simple weightlifter trying to understand any of this Reply @ayso2127 @ayso2127 4 years ago (edited) Thank ya Reply @levansegnaro4637 @levansegnaro4637 4 years ago (edited) so the lysosome is more of a recycling bin then a garbage can. 1 Reply @keshavsingh2484 @keshavsingh2484 3 years ago (edited) thanks Reply