What Causes Aging? - David Perlmutter MD with Dr. David Sinclair | The Empowering Neurologist EP. 109 David Perlmutter MD

What Causes Aging? - with Dr. David Sinclair | The Empowering Neurologist EP. 109 DavidPerlmutterMD 99.6K subscribers Subscribed 1.1K Share 34,178 views Jan 24, 2021 Fair to say that we all assume that aging is inevitable. In reality however, there is no biological law that says we must age. Over the years we've seen a variety of theories proposed to explain why we age including the accumulation of damage to our DNA, the damaging effects of chemicals called "free radicals,” changes in the function of our mitochondria, and so many others. Our guest today, Dr. David Sinclair, believes that aging is related to a breakdown of information. Specifically, he describes how, with time, our epigenome accumulates changes that have powerful downstream effects on the way our DNA functions. Reducing these changes to the epigenome is achievable and in fact, even taking it further, his research now reveals that the epigenome can be reprogrammed back to a youthful state. David A. Sinclair, PhD, AO is Professor of Genetics at Harvard Medical School, and is the author of Lifespan - Why We Age and Why We Don’t Have To. He is the Founding Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. One of the leading innovators of his generation, he is listed by TIME magazine as one of the “100 most influential people in the world” (2014) and top 50 most important people in healthcare (2018). He is a board member of the American Federation for Aging Research, a Founding Editor of the journal Aging, and has received more than 35 awards for his research on resveratrol, NAD, and reprogramming to reverse aging, which have been widely hailed as major scientific breakthroughs and are topics we discuss in our time together. In 2018, Dr. Sinclair became an Officer of the Order of Australia, the equivalent of a knighthood, for his work on national security matters and human longevity. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others. In closing, I really need to say that Lifespan (https://amzn.to/3sSoCNS) ranks as one of the most influential books I have ever read. Please enjoy today’s interview. To stay current on Dr. Sinclair, follow him on Twitter (https://twitter.com/davidasinclair) and Instagram (https://www.instagram.com/davidsincla...) ---- For more from Dr. Perlmutter, visit his website: http://drperlmutter.com Follow Dr. Perlmutter for more updates on: Facebook - http://facebook.com/davidperlmuttermd Twitter - https://twitter.com/DavidPerlmutter Instagram - https://www.instagram.com/davidperlmu... Key moments View all Explore the podcast 152 episodes The Empowering Neurologist with David Perlmutter, MD DavidPerlmutterMD Podcasts 116 Comments rongmaw lin Add a comment... Modern Healthspan Modern Healthspan 2 years ago (edited) My wife and I really appreciate Dr. Sinclair, he inspired us for our biological age is possibly can be reversed. Next year, I'll be 60. We started our NMN & Resveratrol journey a year ago and got more than we expected result. We are feeling much younger, more energetic, have motivation to learn all sorts of things. we reversed our biological age sucessfully last year. We are very grateful to reconfirm that "It's Never too late" indeed is true. Thank you! 43 Reply 4 replies Martin Smith Martin Smith 1 year ago I’m a huge fan of both your work. We are very lucky to have direct exposure and so fortunate your both willing to give your time to educate, and personally hugely appreciative. 2 DavidPerlmutterMD Reply Lynn Nestor Lynn Nestor 2 years ago High quality content from both doctors 💙 and as fellow Aussie so proud of dr Sinclair’s passion for making a difference today and tomorrow👌😇 5 DavidPerlmutterMD Reply DavidPerlmutterMD · 1 reply Aaliyah Lee Aaliyah Lee 10 months ago “The end of biological aging would not mean the end of death in any way. It’s more like a Summer evening when you were a kid, and your mom called you inside. You just wanted to keep playing, have a little more fun during sunset before you went to sleep. It’s not about playing forever, just a little longer, until we feel tired.” That is the most beautiful way of describing the want to prolong life I’ve ever heard. So it's just like that. We only live once, and life is something we can never restore once it's already gone. This urged me to slow down my age process, and so much grateful of Dr. Sinclair's podcasts about NMN supplement's benefits in our body as we age. I have been taking NMN by Vitruvin Nutrition for over a year now, and just like what they say in their reviews online, it resulted to me an impressive benefits. My energy levels are through the roof, no more fatigue, no more medical issues. 1 Reply Unholy Quail Unholy Quail 1 year ago I love this interview. I have seen Sinclair in other interviews struggeling to have a proper conversation on his level. He seems uneasy in explaining and conveying it to individuals that are not on his level of knowlegde and expertise. But here he seems sharp as a knive and you kept him this sharp throughout the interview. Very well done. 2 Reply CrumbleLives CrumbleLives 2 years ago One of the best YouTube videos I’ve ever seen on this topic and I’ve watched dozens and read the book. Excellent interview and interviewing. 5 Reply DavidPerlmutterMD · 1 reply Henry Stidston Henry Stidston 1 year ago Thank you very much Mr. David PerlmutterMD for asking the right questions of Sinclair which I haven't heard asked of him elsewhere. Thoroughly interesting, please keep the updates coming, I've subscribed to your channel. 1 Reply DavidPerlmutterMD · 1 reply Francis Santora Francis Santora 2 years ago Great podcast, thanks so much for doing this! I'm excited for more content of this type. I've newly subscribed! 4 Reply DavidPerlmutterMD · 1 reply Drew Drew 2 years ago Sinclair always dropping knowledge 🧠 18 DavidPerlmutterMD Reply Joakim Fridlund Joakim Fridlund 2 years ago Really liked the part where you praised him for giving credit and space in his book to his coleagues in the lab 27 Reply DavidPerlmutterMD · 2 replies Billy Hanafy Billy Hanafy 1 year ago I think this is the most comprehensive interview with Dr. David Sinclair so far. Thank you Dr. David Perlmutter. Cheers (Red Wine of course:) 1 Reply DavidPerlmutterMD · 1 reply Your Total Body Your Total Body 2 years ago The idea of combining these protocols with those of Dr. Dale Bredesen for brain neurogenesis is so exciting!!! I am a Brain Health Coach and am going to immediately start incorporating some of these with my clients. Thank you so much for all you do!!! 2 Reply William Earl William Earl 2 years ago Fasciniating discussion. I am 69yo and obviously find such chats so relevant to my life. But I am probably not alone in wondering how successful research that extends life 10-20 years, will effect population numbers. 1 Reply NGJ NGJ 2 years ago (edited) Thank's to Dr Sinclair! We are big funs of your work! ✌❤ 4 Reply O Sebastian O Sebastian 2 years ago Thank you for this fantastic interview. 2 Reply DavidPerlmutterMD · 1 reply flowgo flowgo 2 years ago love dr Perlmutter.... what a beautiful guy, speaker, writer (and dr Sinclair of course! ) 7 Reply Doug H Doug H 2 years ago No one has done as much for young mice with their optic nerves crushed by David Sinclair than David Sinclair has. 1 Reply 1 reply Peter Peter 2 years ago Would like to see Dr. Sinclair weigh in on the NAD+ salvage pathway and the influence of food components. I looked at the studies discussed by Nichola Conlon, PhD, and they indicate that substances like EGCG, quercetin, and apigenin have significant positive effects on the salvage pathway, which might preclude use of NR and NMN, especially when combined with exercise and some form of fasting. Also, one study indicates that within the tested range there is an inverse relationship between protein consumption and NAD+ Reply C C C C 1 year ago Gotta love Dr. Sinclair. 2 Reply DavidPerlmutterMD · 1 reply abc abc abc abc 2 years ago I see Dr. Sinclair, I click. 28 DavidPerlmutterMD Reply DavidPerlmutterMD · 4 replies Lea Pustetto Lea Pustetto 12 days ago Jerry tennant in his book, (healing is voltage )explains why the newt grows it limbs back. It's all to do with voltage. I thought you may have heard about him. Cheers great interview by the way Reply Nayma de Linhares Garbin Nayma de Linhares Garbin 2 years ago 👏👏👏🇧🇷🙏LOVE YOU 2!!!!! Have both books 📚!!!!!! 4 Reply 1 reply Joe Blow Joe Blow 1 year ago Yaaay! And really enjoyed the higher level of discussion for us laymen. Reply Ligia Sommers Ligia Sommers 2 years ago Wonderful, thank you 🙏🏻💖🌷 2 Reply A B A B 1 year ago Phenomenal Dr Perlmutter 1 Reply Whitney Kelly Whitney Kelly 1 year ago I hope he also honored all the mice who are giving their very lives for this research!! 1 Reply Cindy Radison Cindy Radison 10 months ago Honestly, I just don't want to be a wrinkly grey-haired useless woman who can’t remember stuff in my ripe age. If I can get older and be able to sustain my body slowing down aging or even biologically reverse aging to my prime, that is ideal. Obviously, nobody can live forever, but I feel like we can live a lot longer, so why not slow our age rather than age slowing us down? This is why I am constantly taking Dr. Sinclair’s NMN, a NAD booster and indeed a health provider. With NMN Vitruvin Nutrition (500mg) a day every morning with protein drink and Greek yogurt, it has radically changed everything. All sorts of problems have disappeared. Now, age is just a number. 1 Reply Han Hai Han Hai 2 years ago Did Dr. Sinclair talk about his daily routine in this video? I'm trying to find a new list if there is any, I remember he talks about it in one other video Reply 1 reply Lam CM Lam CM 1 year ago Indeed we are fearfully and wonderfully made! Praise God! (Psalm 139:14) 1 Reply Shel Chicago Shel Chicago 1 year ago Am I the only person to notice that Dr Sinclair looks younger in this video than those from 7 years ago. He hasn’t aged a bit at the very least. Look up his old videos and compare for yourselves. 1 Reply DavidPerlmutterMD · 2 replies Gabrielle Heard Gabrielle Heard 2 years ago (edited) Always have my dose of resveratrol in my half glass of red wine diluted with water 50/50 and dark chocolate every evening ☺ Reply 11 replies D Hayabusa D Hayabusa 2 years ago Can anyone recommend any brands I can look into when purchasing NMN supplements? 1 Reply 4 replies Gladyslips Gladyslips 1 year ago The worst thing for ageing is thinking about it, celebrating birthdays annually, telling yourself your another year older.. So everyday tell yourself your a day younger, and don't use phrases like how Old are you ask the age not how old are you, Stop using the negatives... I'm a year younger next year.. I'm a day younger tomorrow. Reply Not Anna Jones Not Anna Jones 2 years ago Dangers of Metformin: numerous, including vit B 12 and vit K interference. Vit MK7 is the wonder vitamin IMO. Taking Metformin for “health” is crazy. Reply Martin Smith Martin Smith 1 year ago Wow. Thank you🙏. 1 Reply brenda peplow brenda peplow 2 years ago Interesting, If we go back in time to the original First pair of humans,according to the bible we were never Originally created to die, We could have lived forever if We humans didn’t decide that we knew better than God and we went our own way of doing things . But the good thing is that Everlasting live on a paradise earth is still open to us, because God is going to make all things new, and those words are faithful and truth. The more we learn the more we realise the bible is true.this following Verse in the Bible came to my mind it’s in Romans chapter 5 verse 12 That is why Through one man (Adam)sin entered the world, and death through sin, and so death spread to all men 2 Reply 5 replies E J E J 1 year ago 52 years old, looks 30. Yea, I trust him. Reply Kay Allen Kay Allen 2 years ago I would like to start taking resveratrol and NMN but am fearful about possibly activating cancer. Breast cancer DCIS 20 years ago. Is this a valid concern? Reply 1 reply Misbah Jassem Misbah Jassem 2 years ago NMN need more time to get better results on human Reply Luna n Luna n 1 year ago One question would be the paper on mnm intake helped cancer cell growth ... Reply 2 replies Vivian Oosthuizen Vivian Oosthuizen 1 year ago Every living thing ages Reply Ken Abelson Ken Abelson 9 days ago (edited) Aging is not inevitable? Are you Zeus? Insane. Reply Yasmin A Yasmin A 1 year ago Two Capricorn Davids interested in biohacking Reply Prince Of Babylon Prince Of Babylon 1 year ago Anyone know where can buy NMN and RESV best company name ? Reply Inmo Arq Inmo Arq 2 years ago En idioma español..gracias Reply 1 reply Pure Strength Pure Strength 2 years ago When did this interview take place? Reply DavidPerlmutterMD · 1 reply Darek Birton Darek Birton 1 year ago David you dyed your hair too dark. It is obvious fom watching previous videos. You need to be consistent with the dye and make sure it is the right color... 1 Reply Maddy Bee Maddy Bee 2 years ago Talking about the sun and it’s properties for causing cancer, so which is it, get some sun for vitamin D, or stay out of the sun? 1 Reply 2 replies Vivian Oosthuizen Vivian Oosthuizen 1 year ago And you only want to know so you can mess with it Reply ET Himself ET Himself 2 years ago So why not just take NAD sold at health food stores? Any help for this? Reply 8 replies Cosa Ovidiu Cosa Ovidiu 2 years ago <3 <3 <3 1 Reply Jenesia Girl Jenesia Girl 1 year ago ⁰and p0p Reply Lynne Behrens-Hanna Lynne Behrens-Hanna 1 year ago L Reply