Peter Attia MD & Nir Barzilai on longevity and metformin, Rhonda Patrick on metformin using

204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D. Peter Attia MD 260K subscribers Subscribe 2.2K Share 106K views 10 months ago View episode show notes here: https://bit.ly/36CzHME Become a member to receive exclusive content: https://bit.ly/3k03Sk6 Sign up to receive Peter's email newsletter: https://bit.ly/390bX5U … 238 Comments rongmaw lin Add a comment... Peter Attia MD Pinned by Peter Attia MD Peter Attia MD 10 months ago In this episode, we discuss: 0:00:00 - Intro 0:00:08 - Insights from genetic studies of centenarians and twins 0:11:13 - Genes with protective variants that aid longevity 0:22:23 - The relationship between growth hormone and IGF-1 0:35:37 - Use of growth hormone as a longevity tool 0:44:29 - Longevity genotypes: the role of APOE e2, Lp(a), Klotho, and CETP 0:50:04 - The correlation between high TSH and longevity 0:56:30 - Important pathways for longevity 1:04:38 - Insights from centenarian studies, nature vs. nurture, and more 1:14:56 - The contraction of morbidity that comes with improved healthspan 1:20:56 - Defining healthspan 1:26:14 - Unique perspectives and positive attitudes of centenarians 1:33:32 - Lessons to take away from centenarians 1:38:48 - Metformin overview: history, studies, and potential for gero-protection 1:50:07 - The TAME trial (Targeting Aging with Metformin) 1:59:29 - The challenge of studying metformin in animals models 2:07:27 - How data from the TAME trial could provide insights into biomarkers of aging and facilitate a future study on proteomics 2:14:54 - The search for biomarkers to identify who can benefit from treatment 2:26:29 - The impact of metformin on exercise, and finding the right indication for the use of metformin 2:39:36 - Are NAD precursors geroprotective? 28 Reply 6 replies coronadentalarts coronadentalarts 10 months ago Peter , Thank you so much for kicking "educational podcasts" in the balls and showing them the path forward to what the laymen like myself are craving . Long format educational podcasts done right are cocaine for the new kind of learning addicts like myself . Im 54 years old and just beginning to appreciate the information i choose to gather equals a better me . I love the variety of great guests and most importantly how you steer the conversations with your questions , which i believe is what makes these kind of high end podcasts so informative . Granted , I am just a regular guy and constantly have to rewind these talks to try and keep up and absorb these kinds of talks and most of the time I find myself lost in trying to track the scent trail of understanding . I wish that my brain could have a more sponging attitude with your podcasts but i am grateful what i can retain and that you are taking my health understanding to a higher level . Cheers to you for your free to all educational services you have provided and carry on with . 38 Reply 2 replies Bill C Thompson - Live Healthy, Finish Strong Bill C Thompson - Live Healthy, Finish Strong 9 months ago I personally have no interest in living to 100, BUT strongly desire to be as healthy as possible until I die at 80-85. Reducing carbohydrates to a minimum and some intermittent fasting has transformed my health. I started this at age 62. I turn 66 next month. I lost a lot of weight, came off ALL medications (2 for hypertension), reduced my HbA1c from 9.9 to 4.9 (without medication). I was also able to give up my CPAP for sleep apnea. 41 Reply 6 replies Dolores Geyer Dolores Geyer 10 months ago Great interview. You are both comfortable having a very interesting conversation. I would love to be in these aging studies. I am 80 years old, in good health, look younger than my years. My Dad lived to 93, died from a fall. Mother died from lung cancer at 68, was a heavy smoker. Why aren’t these studies looking at someone like me? 22 Reply 1 reply tim mulder tim mulder 10 months ago Like I've said before and I would like to say it again. In order to challenge yourself in the pursuit of physical fitness you need to do something that you enjoy. Improving the quality of your life not necessarily prolonging your life needs to be the primary motivation. One of the greatest benefits of regular vigorous exercise is you gain the strength to do the things that you want to do. I mean just a normal everyday activities are one thing but to do things like going for a hike bowling on a bowling league or even playing ice hockey again after the age of 60. One of the great lies that we've heard over and over all of our lives is your too old to do this and you're too old to do that. But we all need to start somewhere. In my own experience after retiring early at 62 is I decided to start rollerblading and ice skating. Then I began to start in calisthenics and then from there I went into high intensity interval training. Now I play hockey 3 to 4 times a week I play roller hockey ice hockey and street hockey just day before yesterday I had three on three hockey at the local inline roller rink against teenage boys and Young 20-year-olds. I play twice a week at the local ice rink scrimmage hockey against men half my age. But I said all that just to say this that in order to enjoy what you are doing you need to get better at it and so that became a motivation not so much to be better than the other guy but to be the very best that I can be!! 22 Reply 2 replies Pramuji Singgih Riyanto Pramuji Singgih Riyanto 1 month ago I love how the interviewer asks the questions.... Critical, polite n straight-forward n has ample background knowledge. 2 Reply BioHacking FinTech BioHacking FinTech 6 days ago This channel is a treasure trove of valuable health information. Really enjoyed the segment on Metformin as I’m currently taking Berberine and moving to dihydroberberine this week to evaluate its efficacy. Researching Metformin now. Planning to binge watch several podcasts/videos over the next month or so. Reply Jamiselle Palacios Jamiselle Palacios 10 months ago I am new to your podcast, very interesting subjects and totally new concepts for me. Grandma lived to 95 but my mom died at 64. I am in my 40’s with rapidly hormone changes and not to mentioned had gray hair since my 20’s. Would like to know more about visible aging components and their impact to longevity. 8 Reply Tim McLaughlin Tim McLaughlin 3 months ago Well I did not make it through the whole pod cast but tried to hang with you guys. My Mom who I care for is 101.Her Father lived to be 100. I am 67. I take no prescribed meds. I am an active Triathelete and compete regularly in Age group USAT racing. I believe my diet is my medicine. We are plant based 98% although I will eat Eggs at times. So, I find the topic very interesting. I am 138 lbs and can out run out cycle and swim many people 1/2 my age. Staying active is key and eating well. Live well and hey if it goes long then fine. 4 Reply 2 replies Red Bull Red Bull 10 months ago Thanks Dr. Attia! I’m 54 year old male. Last 2 years; 500 mg metformin X2 daily. 200 mg Test Cyp per week. I train almost every day. I’ve put on muscle, lost fat. Now on peptides for more GH release and I’m visibly turning the clock back no matter which clock you use. My experience with metformin has been great! 26 Reply 6 replies Javad Hashtroudian Javad Hashtroudian 9 months ago My academic background is organic chemistry, biochemistry, and neurochemistry. In my 20s I abused my brain and body through alcohol tobacco and cannabis. I have been a software engineer for 40 years. I still would read biology papers and started intermittent fasting around 2000. In 2012 my GP informed me that tests showed that I was pre-diabetic and pre-hypertensive. Since I don't like drugs that don't get you high I refused pills. I said if I can't control my blood pressure and sugar in 6 months through diet and exercise I'll talk about pharmaceutical intervention. Both my A1C and blood pressure are good now. Now at 75 I don't take any pharmaceuticals while every one of my siblings and cousins take at least one pill a day, some as much as six different pills each day. I do take supplements, intermittent fasting 5 days a week, exercise every day averaging burning 2500 kcals a day, meditate, and have peace and fun. I look much younger than my 75 years and smile a huge amount. I laugh a lot at myself. I believe my attitude keeps me young. My only health concerns are aching knees and peeing many times a night. I discovered that THC-O acetate helps me with urination but gets me high and very tired next day. If I was still a biochemist and had the funding I would do research on THC and TBD derivatives for too much urination. Last point I wish metamorfin was available without prescription. In the meanwhile I have started Berberine and NMN. 6 Reply Kevin Gilbert Kevin Gilbert 10 months ago Great interview Peter! Good timing just read Nir's book "Age Later". Good read. Looking forward to further research data from TAME. On a side note, I hope I fall somewhere between a patient and "just" a social media follower! LOL! 5 Reply 1 reply Nils from Alaska Nils from Alaska 10 months ago 1) Interesting podcast; thanks for posting. 2) Genes clearly play a role in longevity. But our lifestyles... what we eat, how much we exercise... can influence the expression of our genes. 15 Reply 4 replies Pramuji Singgih Riyanto Pramuji Singgih Riyanto 1 month ago This is the best podcast on Metformin n biomarkers. I love it. 1 Reply Chris Purdue Chris Purdue 10 months ago Very interesting. My wife was put on Metformin and felt absolutely miserable the entire year that she took it. She was tired all the time which negatively affected her mental health. As soon as she stopped, it went away. 16 Reply 3 replies Esmeralda Cole Esmeralda Cole 9 months ago Thanks for the information , very useful! 2 Reply Claudette Sechler Claudette Sechler 10 months ago So great! Wonderful guest! Gives me such a perspective on metformin 3 Reply simon mojarad simon mojarad 10 months ago I love it and it’s refreshing, Peter for the first time started challenging his guest when they refer to flawed studies. 9 Reply Dachshund mama Dachshund mama 6 months ago Lots of centenarians never got married...😉 I believe lifestyle is the key for health/life spend. Exercises, food, good relationships, freedom/autonomy, good income, unconditional love (not only human), active brain, variety in general (no boredom), sunlight, nature, sleeping, good stuff and a little bit of stress (just a little). 3 Reply jayalanlife jayalanlife 10 months ago Nir is looking younger with every podcast, maybe he should include skin health. 11 Reply 1 reply John Egan John Egan 10 months ago Has any research been done concerning people with accelerated aging and comparing their genomes and gene expression with the centenarians?I once had a Dental patient with precocious puberty and her condition seemed to suggest accelerated aging and reduced life expectancy. 3 Reply Ad Am Ad Am 10 months ago ’As useful as a warm bucket of hamster vomit’ Peter Attia MD Interesting and entertaining as always! Grateful to you, your team, and all the interesting guests! 8 Reply look up look up 3 months ago (edited) This conversation type is an official sport of the nerd-olympics🤣. A total matrix-brainiac-download for health nerds like myself... completely fanning out.😍🧠🤓 Reply Gregory Ludkovsky Gregory Ludkovsky 10 months ago Long time no see ! Nice to have you back , Peter 1 Reply Bjarne Tungland Bjarne Tungland 9 months ago Solid podcasting there. Good question about the evidence of metformin, nmn. Ect. 2 Reply Michael Domansky Michael Domansky 10 months ago Between taking my Metformin, NAC, Benfotiamine, and Ivermectin I am completely inflammation free! No arthritic limp, no back pain, no bursitis. I take no NSAIDs or Tylenol ! 6 Reply 4 replies ChillerHR ChillerHR 10 months ago (edited) it would bi nice to know, if one wants to experiment a little, what to check prior to taking Metformin for a spin, and how often and what to check during taking it (in terms of possible negative effects I mean), how much to take and how often, and what type of symptoms or effects to be mindful about while on a drug…that would be nice 8 Reply 4 replies Jean Peuplue Jean Peuplue 2 months ago hello Peter, I was interested in this interview, because I am affected by acromegaly, and as you probably know, it is a benign tumor of the pituitary gland that causes an endless production of Gh, at the beginning my Gh levels were at 1500ng / ml, for an IGF-1 level at about 750 ng / ml, after two surgeries 10 years apart, the tumor has been reduced by more than 90%, Gh levels have decreased, but IGF-1 still remains around between 285 and 550. After informing about Ladron's disease, person having a problem dimerizing Gh in the liver, receptor problem, I come to think that it is possible that some receptor acromegalic people is too sensitive, or works too much to the production of IGF-1. Finally, it is true that with my high growth hormone level, I heal very quickly from my injuries, whether orthopedic or other, and I am rarely, if ever, sick but i develop some type of tumeur, begnin for the moment. 1 Reply Zandra Rose Zandra Rose 9 months ago Metformin had me seriously planning my suicide. I am so glad I realized it was the drug and not me. 7 Reply 1 reply The Calming Gourmet The Calming Gourmet 10 months ago According to 23&Me, I'm Ashkenazi. Also, if you look at what the state of my health should be according to 23&Me, I should be a total, overweight mess. It may be "in the genes," but it's mostly up to you. I'm in great shape in spite of what the gene report looks like because of food control. All my immediate family have passed, so I'm doing what i can to see if i can make it to 150 y/o! 4 Reply Heli Doggett Heli Doggett 1 month ago What is the effect of emotional and mental resilience on longevity? Reply M bnto M bnto 10 months ago Question. I’m at minute 12 and 3 hypotheses are suggested: environment, good genes, bad genes. What about the role of stochastic processes in disease, which I understand to be formidable? Maybe centenarians are lucky? 3 Reply Tim Burke Tim Burke 10 months ago I've come to the conclusion that this stuff is super complicated and I'm too stupid to understand it all. I'm still gana exercise though. 99 Reply 25 replies Rose Perozzi Rose Perozzi 2 months ago Great topics. Merry Christmas 🎄🎁 Reply boldandcourageous 41 boldandcourageous 41 3 months ago (edited) Metifomin info starts at 1:39 yes over an hour in! 1 Reply Thomas Wipf Thomas Wipf 1 month ago 5mg/day of mk677 is one of my favorites for recovery Reply Nahulanham Nahulanham 10 months ago What's even more important then what HGH does as it is secreted from the pituitary, is what psychological habits lead to its stimulation or dystrophy. 5 Reply the future lasts a long time the future lasts a long time 10 months ago Can you link the metformin studies, so I can send them to my GP? 2 Reply Irish Talks Irish Talks 10 months ago What about fertility issues in men taking metformin. Also I feel some of these things talked about could be possibly helped out by doing a carnivore diet. 2 Reply Tim Scannell Tim Scannell 10 months ago Great work 2 Reply Daniel Daniel 10 months ago (edited) Maybe we should look into studying taking low-dose methimazole or propylthiouracil in healthy, non-hyperthyorid individuals to see if there is a longevity benefit. 2 Reply Zack 120 Zack 120 9 months ago (edited) 2:33:34 - no, 4 months is a rather short time window of one's life. It is a major short coming of many if not most/all intervention studies in humans or animals. In other words it's just a snap shot of a life span, hence it's extrapolability to overall benefits of health especially longevity is small. Sometimes it can even be mistaken when the short effect is transient and the longer effects are just the opposite! Reply J K J K 10 months ago Excellent Info!!! 2 Reply White Ninja White Ninja 10 months ago Peter is profoundly intelligent. I hope he always puts his time to good use. 6 Reply Audrey Hurley Audrey Hurley 10 months ago How do I sign up Nir ? I’m interested in getting into your test study, I live Austin, TX area? Is there a study here? 2 Reply ChessMasterNate ChessMasterNate 9 months ago The reason Centenarians are upbeat is because their Amygdala has atrophied. That is the part of our brain that is constantly preparing us to react to negative or dangerous things. 2 Reply 1 reply Bill99 Bill99 10 months ago One question and one comment: Q. I've looked here for the two metformin articles Dr Barzilai referenced to show to our primary care Dr's but can't find them. Any help? Comment: I don't think the Dr's prescribing metformin after reading the articles is still true. I suspect that off label prescriptions for anything are mostly a thing of the past because of the hysteria generated over covid off-labels and the restrictions placed on individual physicians by their practice groups and their malpractice insurers. Fear of malpractice lawsuits has chilled the practice of medicine into paralysis. 2 Reply Tim Burke Tim Burke 10 months ago Seems like we are better off talking about berberine instead of metformin 22 Reply 1 reply J. M. J. M. 10 months ago Metformin has many great properties, but you don’t want to be on in while you’re building muscle! It promotes AMPK, muscle growth is all about MTor.. 1 Reply outofchips outofchips 10 months ago Longevity = experience repeated 1 Reply _ _ 8 months ago Thanks for introducing video to the podcast. 1 Reply Tim Burke Tim Burke 10 months ago Do their genes preserve their cardio respiratory health? Are they in the top 3% without exercising? 1 Reply Pam Lovell Pam Lovell 10 months ago My great aunt who was the eldest child and obese the majority of her adult life lived to 100. Her youngest sibling -- my grandmother the baby of the family-- was thin her entire life died from Alzheimers at age 74. Go figure. 8 Reply 3 replies Joseph1NJ Joseph1NJ 10 months ago So Peter asks If GH was so deadly, where are the bodies? He answered his own question, we just don't have the data. 1 Reply 1 reply Elizabeth K Elizabeth K 10 months ago Couldn't take METFORMIN, so switched to BERBERINE. Works similarly. 3 Reply 1 reply Fred Branson Fred Branson 10 months ago (edited) Peter please cover SGLT2 for longevity. Metformin is old news. Agree with you in regard to performance athletes or those that focus on exercise. SGLT2, however, extremely interesting for geroprotection (body composition, inflammation, cardio & renal protective). 4 Reply Borje Lindh Borje Lindh 9 months ago Metformin seems to lower inflammation but also testosterone, growth hormone, mTOR response etc. These things are really good if you for example have cancer. But the same effects also blunt the effects from exercise. So my current understanding is that though metformin is good if you want to get old, but be aware of the side effects. Comments? 2 Reply 2 replies sandor1969r sandor1969r 9 months ago (edited) The people that lives longer happen to live in places where food is most natural no chemicals like the Hunza tribe for example. Costa Rica has ten times more centenarians than here in USA as Costa Rica food it is reach in nutrients and minerals as they use water that came down from rives near vulcans to irrigates their crops and probably never eat fried food or drink fluoride in water , just two very bad things for the gens. 1 Reply C. Spartacus C. Spartacus 10 months ago Need a TLDR on this one. 2 Reply 2 replies Gloria Spau Gloria Spau 9 months ago I am 81 on metformin for one year, lost 15 lb, 5ft 7in , 134, 1000 mil a day, at one time my liver numbers were high, after taking metformin normal, fasting sugar 5.6, not so good rising from sitting position....muscle strength not so good. 2 Reply 2 replies Alex Brothers Alex Brothers 10 months ago (edited) Have you ever sat with an "average 95-102" year old? I have and most of them can hardly move and have had enough. Keep your body moving, exercise, ideal body weight and love what you do. 19 Reply 2 replies Tam Pa Tam Pa 1 month ago Yes, Peter, really great job, your knowledge and effort to convey new knowledge to people, but first of all, more types of genetic homogeneity should be included in any research regarding longevity. not only Ashkenazis..! Reply Nobodyatall Nobodyatall 10 months ago Hi Peter, what inhibitors do Nir and you talk about in 14:46 ? ctap inhibitors ? Thanks Reply 1 reply unXnown unXnown 10 months ago wow, that was sooo intense Reply Marge Simpson Marge Simpson 1 month ago Sure with ApoE$ folks looked in demented patients for index cases which how the RR was overestimated, today the E4/E4 has regressed to the mean maybe ~4 Reply SomeAssemblyRequired SomeAssemblyRequired 8 months ago I have a hard time understanding Dr. Barzilai's response to, as he put it, hundred-year-olds who come to him and "want something"; he refuses because he doesn't want to cause harm. But he also reports centenarians as having a 30% annual mortality rate! Every year! Facing such odds, an oncologist would probably be requesting compassionate use exemptions to throw in the kitchen sink to help a patient. Informed consent is everything for me under such circumstances: HGH, anabolics, literally anything else I thought might help. Risky case studies can also be an amazing source of new research approaches. For the very aged with a strong will to self-experiment, I see almost no moral limits on trying combinations of existing compounds. The asymmetrical risk of inevitable death makes the calculus clear. Reply blaney6591 blaney6591 10 months ago Episode was confusing and difficult to follow. Can someone post a layman's summary of conclusions drawn? (The link to show notes above only review topics covered, not conclusions). Thanks in advance. 5 Reply 1 reply Helen Forrest Helen Forrest 10 months ago What about metformin causing severe lactic acid build up and causing many deaths? 3 Reply 1 reply Roolenstein Roolenstein 1 month ago What happens to very healthy people who take Metformin? What happens when a healthy person stops taking Metformin after prolonged use? 2 Reply 1 reply Audrey Hurley Audrey Hurley 10 months ago Drs I’ve asked my doctor about prescribing Metformin and rapamycin. Did blood work he stated no diabetes so no need for either. I explained and he knows I’m a care giver with no real caregiver support for myself. Still got no. So would either of you would you prescribe to me? Reply 1 reply WorldsBestGuys WorldsBestGuys 10 months ago You will know when the longevity research has actually become successful when all of this stuff is censored- the general population will not be allowed to live so long when there’s all these current population related issues, unless there is a need found for them such as slavery. 4 Reply Maud Muller Maud Muller 10 months ago My mom lived to 104 1/2. Too bad you couldn’t have studied her! 3 Reply Marge Simpson Marge Simpson 1 month ago TAME illustrates the fragility of composite endpoints, CEs are poison. Reply Alexis Espinosa Alexis Espinosa 10 months ago Will you ever interview Prof. Valter Longo? 5 Reply 1 reply zazzleman zazzleman 8 months ago I get an uneasy feeling Peter is conducting a passive-aggressive campaign against David Sinclair. A lot of what I have seen over the past 12 months is pointed and silly nonsense. Reply Bjorsa M Bjorsa M 10 months ago You guys are "too harsh on Kersh", if you know what I mean. Pushing garden variety religious schticks randomly into totally non-relevant discussions adds spice to online life! And we want more life, that's why we're here? See? It all makes sense now and I'm sure I don't need to remind you Jesus gave us that answer too. Reply guy chase guy chase 9 months ago Metformin is toxic to the liver - how can it help with longevity ? 1 Reply 2 replies NeedGod dot com NeedGod dot com 10 months ago The gospel I would say is the main message of the Bible, it is the work of Jesus Christ, the Son of God and what He did on the cross for all of humanity. Despite the efforts of any person, we cannot earn our way to heaven, Romans 3:23 says: "For all have sinned and come short of the glory of God". Anyone can examine themselves and know that even though yes sometimes we can do good, we also do evil at times, we commit moral crimes, we rebel against God, or as known otherwise we sin. We lie, we steal, we blaspheme God, we can lust and have hate for our brother in our heart, these are just some of the sins more than likely every person on earth has committed. God is loving, holy and God is merciful among other attributes but He is also just, perfectly just. Like any crime sin has to be punished, if God did not punish sin then He would be unjust, He would be corrupt, someone has to take the punishment. Romans 6:23 says: "For the wages of sin is death but the gift of God is eternal life through Jesus Christ our Lord". This is talking about spiritual death, not physical death, if you die in your sins then you go to hell. There is good evidence that humans have souls, near death experiences are one of those evidences. There is a part of you that lives on past your physical body. God sent His only Son to earth about 2000 years ago, His Son is Jesus Christ. Jesus Christ is the promised Savior of the world, He fulfilled hundreds of prophecies by coming to our world. Jesus was born of a virgin, lived a sinless life and was crucified on the cross as a payment for our sins. God poured out His wrath on Jesus in our place, meaning the justice of God is satisfied and sin is punished. While we were still at enmity with God, God still wants to save us, Romans 5:8 says: "But God demonstrates His own love toward us in that while we were yet sinners Christ died for us". 3 days after Jesus was crucified He rose again proving that His payment was enough and that He was who He said He was, the Son of God. There is real world evidence for the life, death and resurrection of Jesus Christ, this is not just a nice story. Scripture tells us to repent and put our trust in Jesus, to follow Him as Lord. Repentance means a change of mind which means to turn from a life following sin to a life following Christ. Salvation is a free gift and it cannot be earned, no one can be perfectly moral on their own, it is impossible, this is the only way to be in the presence of God in heaven. It is important to reiterate that we cannot save ourselves, it is the gift of God for one to be saved. Cry out to God to have mercy on you, plead with God to save you. Ephesians 2:8-9 says: "For by grace you have been saved through faith and that not of yourselves, it is the gift of God, not as a result of works so that no one may boast". Salvation is a gift. There is no other way, Jesus Himself said that He is the way, the truth and the life and no one comes to the Father but through Him. Jesus is not just a way, a truth or a life. Romans 10:9 says: "That if you confess with your mouth Jesus as Lord and believe in your heart that God raised Him from the dead you will be saved." 8 Reply 2 replies Doris Castillo Doris Castillo 10 months ago All the way from Republic of Ireland filipino 1 Reply N Kersh N Kersh 10 months ago The Bible is the written word of God. Every word is absolutely true. The answer to living forever is through Jesus Christ. He is the answer. 6 Reply 12 replies Paul James Paul James 10 months ago What about Resveratrol ? 2 Reply 1 reply Jessie Davenport Jessie Davenport 1 month ago So many law suits against metformin stroke , heart attacks , dementia etc 1 Reply 1 reply Richard Dickson Richard Dickson 10 months ago I often wondered what happened to Paul Simon after he dropped out of the music scene. 2 Reply 1 reply Erast Van Doren Erast Van Doren 10 months ago The aging biomarker argument is stupid, IMHO. Yes, you can manipulate it. But maybe it is what it takes to delay aging - to do exactly those manipulations daily. Lower your glucose & LDL, keep albumin high and CRP low, and so on. Do it daily, and you stay young longer. Reply jaswant khalsa jaswant khalsa 1 month ago Are you saying that if we have a chronic disease at 72, forget the things to prolong life to old. Reply Jerilyn Holt Jerilyn Holt 11 days ago Say simply your conclusions! Reply Thomas Wipf Thomas Wipf 1 month ago I wish I saw this video before spending $1100 on berberine, tmg and nmn. Reply 1 reply Mark William North Mark William North 2 months ago energy resonant epigenetics Reply anonymissed anonymissed 1 month ago 5:12 One twin more prone to obesity? Have we seen thus? Reply Lorelei Fajardo Lorelei Fajardo 10 months ago Metformin will inhibits the effects of exercise. 2 Reply 5 replies Velly D. Velly D. 10 months ago My grandma is 99 y old and nobody died in my family under 90 (or was killed by the communists), men and women. I am from Bulgaria, my grandgrandma died by incident with 95+ and ate 15 eggs for breakfast, healthy until she died 3 Reply 2 replies Tumble Sensei Tumble Sensei 10 months ago Metformin.. how to stimulate a TON of lactate production quickly. Wow, what a great drug. 1 Reply 1 reply BinaThere BinaThere 3 weeks ago But why did they have a heart attack? Reply Jay Joseph Jay Joseph 9 months ago Metformin bad for kidneys!! Reply 1 reply Jasboy H Jasboy H 9 months ago Metformin lowers testerone 1 Reply 1 reply pannellclara pannellclara 10 months ago (edited) Dr. Nir Barzilai is all over the place & doesn’t know how to communicate in a way that non medical edu people can follow this conversation - i want to know is: can 2000 mg/ day Metformin somehow benefit my health - yes or no?!! 1 Reply 1 reply Edward Hill Edward Hill 10 months ago THE INTERVIEWER IS OVERBEARING KNOW IT ALL. 4 Reply Jerilyn Holt Jerilyn Holt 11 days ago Who are you talking to? Not to us. Reply J. Diorio J. Diorio 9 months ago Did this guy just make a January 6th reference? He said he didn’t wanna live forever because of all the crap he sees and he just referenced January 6? You mean the one guy that walked in drinking a beer wondering around a capital lobby? I can think of 1 million things worse than that day. See you get these smart people and then they let you know how smart they really are not! 2 Reply 1 reply Y. G. Y. G. 10 months ago useless blabber, as usual w Attia lately. Thanks for updating us about your incompetence. 1 Reply 1 reply Mr Mr 9 months ago You are cutting our life short by dragging on unnecessarily. Reply Sparkling Cyanide Sparkling Cyanide 9 months ago Talked for almost 3 hours and said a whole lot of nothing. Too fractured. 1 Reply Victor Da Silva Victor Da Silva 10 months ago So hard to watch 3 Reply 1 reply guy chase guy chase 9 months ago You don’t understand nutrition- advanced artherosclerosis is due to calcium build up in the soft tissue not HDL or LDL cholesterol What complete tosh you are discussing ☠️🧐😱😱😱🤣😂🤣 Should healthy people take metformin? (benefits vs. negative exercise effects) | Rhonda Patrick FoundMyFitness Clips 68.5K subscribers Subscribe 2.8K Share 144,362 views Premiered Feb 4, 2020 #Fasting #KevinRose #Supplementation Longitudinal studies showed that people with type 2 diabetes taking metformin lived 15 percent longer than healthy controls not taking the drug. This raises the question as to whether the longevity benefits of metformin may extend to healthy people. However, metformin may inhibit exercise-induced benefits, such as cardiorespiratory fitness and gains in lean body mass. In this clip, Dr. Rhonda Patrick gives her thoughts on whether healthy, active adults should take metformin. Listen to the full episode on the Kevin Rose Show: https://podcasts.apple.com/us/podcast... Study: https://www.ncbi.nlm.nih.gov/pubmed/2... About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California. She has done extensive research on aging, cancer, and nutrition. It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach. Learn more about Dr. Rhonda Patrick and her mission for FoundMyFitness at www.foundmyfitness.com #Fasting #KevinRose #Supplementation 448 Comments rongmaw lin Add a comment... FoundMyFitness Clips Pinned by FoundMyFitness Clips FoundMyFitness Clips 3 years ago Listen to the full episode on the Kevin Rose Show: https://podcasts.apple.com/us/podcast/dr-rhonda-patrick-new-omega3-sulforaphane-research/id1088864895?i=1000461297039 More clips from Dr. Rhonda Patrick: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gJAebLkHTAf09y4i7g8Hag8 9 Reply 2 replies Fantastically Fit Fantastically Fit 4 months ago I’m 55 and am a natural fitness competitor. I’ve been a consistent exerciser since is was 18. I’ve never been fat. I’ve always been lean. No inflammatory marker. Yet A1C is 6.0. So I have been using metformin for 3 days. No negative sides so far. I feel no difference in exercise performance so far. 18 Reply 5 replies Brian Booth Brian Booth 2 months ago Thanks Rhonda for an interesting video. I actually bought some Metformin 19 months ago, and after I had bought it I never even took one tablet because of some of the data you have referred to. I have for years participated in around 400 minutes of moderate active exercise for the last 30 years so guess metformin would not have many positive benefits for me but maybe the opposite Reply Nellyfizzle Nellyfizzle 2 years ago I’ve been taking merformin for 7 months and it’s greatly improved my health and training. I’m sure the training improved as a result of my health improving although I’m not sure. I’m training harder, feeling stronger and have more endurance, needing less caffeine, dropping weight and haven’t seen any negative effects to muscularity. I have not done anything different besides add the merformin and don’t take any other chemicals. 63 Reply 25 replies John Lockett John Lockett 1 year ago Thank you for this video. I am 81 and I do take Metformin. My diabetes 2 started about 10 years ago. My Dr. and I starting working to change that outcome. I started taking Metformin 1000 mg, exercising and dieting. My weight was about 88 kgrms.. I am 5'.7". I started exercising on a treadmill. (Set at 3 which at a higher point I will start to run), 30 minutes 6 times a week. The Metformin reduced my appetite so much that after 18 months the doses went down to 500mg. After about 30 month I starting loosing weight and I stopped at 75 Kgrms. My diabetes 2 disappeared, but I still taking Metformin. This medication still affect my appetite, so I stop taking it for about a month and restart again. Dr. for me it was the exercise and loosing the weight. 75 kgrms is my weight when I was 21 years old. Metformin help me by reducing my appetite and now I eat smaller portions. I think it is all about the weight. 25 Reply 4 replies Sigma Female Sigma Female 2 years ago I am not pre-diabetic and taking extended release metformin changed my life. Due to the fact that it decreases appetite, I was able to make changes and eat healthier. I have minimum side effects on the XR. Skin is pulling tighter, same benefits as when doing IF. Love this med. 44 Reply 8 replies Jerry Dougherty Jerry Dougherty 3 years ago Always excellent analysis of a rather complex topic. Thank you for all your amazing work 🙏 5 Reply Aubrey J. Tennant Aubrey J. Tennant 3 years ago I appreciate Dr. R’s default organic proclivities. Especially if your under 60 considering the upside potential to downside risk dynamic. I’m 67 and an exerciser. I almost started Metformin a month ago and because I am not type 2 diabetic - I’m kinda glad I couldn’t get it here in Canada with a prescription. Dr. R’s honest perspective is cautionary but well presented I think. 10 Reply 1 reply HealthAndFun HealthAndFun 1 year ago (edited) If you are not diabetic and just taking metformin for longetivity, don't take on exercise days as it reduces performace as well as inhibites protein synthesis. Take on rest days 24 hours before your next training session, and take the fast acting metaformin. Also you can take Berberin instead. 14 Reply Kitteh Kitteh 2 months ago I've been on Metformin (2000MG) daily for one year, and I have still been able to build muscle and gain strength. The only caveat is that the muscle building has been slower than before I was taking Metformin. Although, my muscles did grow. 2 Reply tiffsaver tiffsaver 13 days ago Dear Rhonda, I just took my first 500mg dose of this stuff and the side effects were a terrible metallic taste in my mouth and stomach distress that lasted throughout the night. What if I just reduced the dose to 250mg, and added a little exercise to my life (I'm very sedentary). Does that sound like a good combination?? Reply La Luna La Luna 11 months ago I don’t think I have ever felt worse than taking Glucophage 500 mg for a week. Severe asthenia, myalgias, GIT issues, dizziness… 5 Reply Anthony Wahl Anthony Wahl 3 months ago What are your thoughts on Metformin effectiveness on cancer inhibition for prevention? There's studies out there on how Optineurin down regulation is possible through taking Metformin supplements thus preventing or reducing some types of cancer. 2 Reply Dennis Fink Dennis Fink 3 years ago We need some professionals like Rhonda to review the research on the 20 to 40 fold difference in lifespan of the Queen Honeybee compared to the worker honeybee that is attributed to being feed royal jelly for slightly longer. Dr. Nessa Carey discusses this as an epigenetic effect in a four year old You Tube lecture on epigenetics! 6 Reply JT Schnow JT Schnow 3 years ago I have/had type 2D and have been on 2000mg of metformin for 2 years. I lift weights and it has turned me into a beast. I believe metformin + weights has a synergistic effect. Current AC1 6.1 down from 10.4. 15 Reply 2 replies JMC JMC 1 year ago We need to take into account the effects of low IGF-1 levels in longevity through lowering MTOR. If Metformin can indirectly reduce IGF-`1 to less than 145mg /dl through suppression of MTOR, then the reduction of all-cause mortality from lower IGF-1 via suppression of MTOR in older persons may play in longevity - Perhaps a more important one. But has anyone looked into sarcopenia induced by Metformin as we age? 8 Reply 1 reply Bradbo3 Bradbo3 3 years ago Im 50 yrs old and Im type 2 for 9-10 years now...and on metformin. But 2 years ago I got serious and really hit the gym and watch my diet extremely close. Lost all the weight and KEPT it off and my A1C is 5.7.....daily glucose readings are normal and my Dr said Im no longer type 2 but wants me to keep taking it. I think Im better off without it....cant imagine how much better I could be physically without the metformin holding me back. 6 Reply Alexandre Magalhães Alexandre Magalhães 9 months ago (edited) I exercise every other day and was planning to take metformin after David Sinclair said he took it in the days he didn't exercise. I'm still searching about it. Thank you for talking about these randomized trials, Dr. Rhonda Patrick. 2 Reply Higher Resolution Higher Resolution 4 months ago (edited) Many thanks for posting this video. In the past 2 weeks, I have been considering taking metformin. I dismissed it's use a long time ago because of the negative side effects. However, a friend of mine, at age 64, has now been using Metformin for 3 months and getting good results. From this talk with Rhonda Patrick, and the fact that I exercise as much as I do, including heavy weight training, there's no way I'm going to take metformin. I worked in a mitochondrial lab at an UC campus, and the idea of inhibiting the efficacy of Complex 1 in the Electron Transport Chain is unacceptable. The only possible benefit of this effect might be that there is less ROS leak from Complex 1, which is the enzyme complex that produces the most free radicals in the matrix of the mitochondria. 1 Reply Nuthan Maharaj Nuthan Maharaj 2 years ago Thank, you have shared critical information and have clarified many issues regarding weight loss. 1 Reply 1 reply Faisal Rafique Faisal Rafique 1 year ago I have recently started Berberine. I am non diabetic so there is no change in my glucose levels even after eating 500 mg x 3 per day. My digestion has got improved since Berberine helps with leaky gut problems. I felt more energy when I started taking it and now that it has become a norm so I don't fee the difference anymore. Reply 1 reply fayiz shaffaq fayiz shaffaq 2 years ago She’s got answers to almost every question I have 4 Reply moestietabarnak moestietabarnak 1 year ago (edited) Since I've been diagnosed with T2D recently, I binge watch many video on all related matters.. from What I can gather (not a medical person in any way, but listening to Dr. Lustig and Dr. Fung and other) Metformin suppression glucose simply simulate the effect of fasting and low carb diet. It make more sense ... And since fasting is in our millions years adaptive evolution, We get the benefit without the risks associated with these drugs. and cheaper than free !( less food to buy heh !) I'll tend toward that more natural process. thank you + other benefit, our metabolism regain regulation without drugs. Why keep paying big pharma ? 7 Reply Encompass Health Encompass Health 5 months ago The age related side effects is what interests me the most. David Sinclair seems to think that by increasing insulin sensitivity that the ATP production from mitochondria in cells becomes more efficient on Metformin. Mitochondria production efficiency is also linked to age-related diseases. 3 Reply 1 reply Tom Jones Tom Jones 1 month ago Dr. Patrick really digs into the data to uncover important information. Reply miao yu miao yu 2 weeks ago I have used 500Mg metformin two or three time a day since 3 months ago. I am a healthy person but I am lazy and never exercise, I am addicted to carbs. Metformin is my life saver. I could eat normal amount of food without craving too much and I lost 15 lbs. Reply Gaz Gaz 1 year ago At 5:48 Rhonda refers to an old study done in 2014 where rats with T2D were given the following doses 30mg per body weight, 100mg per body weight, and 300mg per body weight. I weigh 60kg. So if I were to take any of those doses I would be taking either 1800mg, 6000mg or 18,000mg. These are huge doses - I'm currently taking 425mg and am not diabetic. I feel fine and have not noticed any decrease in my physical performance. I have no plans on increasing the dose. But the question remains: If Metformin reduces one's chances of getting cancer by 31% (see FoundMyFitness Topic - Cancer) isn't this reason enough to take it??? 12 Reply 2 replies Adrian McNeil Adrian McNeil 11 months ago I’m not diabetic but I take it. It makes me a little lazy so I take it right at bed and Im good by morning. I should add that Dr.David Sinclair recommends taking it just 2 or 3 times a week. 8 Reply IvorMektin IvorMektin 3 years ago N=1 here. I took metformin for a couple of years, my neighbor gave it to me. It really does lower blood sugar. I started weights last year and could barely make any progress until I dropped metformin. Months later I added creatine and that made a huge difference. 17 Reply 8 replies David Edwards David Edwards 3 years ago Has anyone seen anything that relates Berberin to reduced exercise benefits, since it's main mechanism is reducing and stabilising glucose level in the same way as Metformin. I have now stopped Metformin after listening to one or two of Rhonda's podcasts about exercise and Metformin not being synergistic. 6 Reply 1 reply Dr. Nancy McClure-Galli Dr. Nancy McClure-Galli 3 years ago Thank you for your always informative clip on Metformin. Tell me has anyone responded to the study recently published in Jena, Germany and reprinted by the Cold Spring Harbor Lab "Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism"? The conclusions based on C elegans mainly are: Late life metformin treatment limits cell survival and shortens lifespan. Metformin exacerbates aging-associated mitochondrial dysfunction causing fatal ATP exhaustion. Old cells fail to upregulate glycolysis as a compensatory response to metformin. The dietary restriction (DR) mimetic response to metformin is abrogated in old animals. PKA and not AMPK pathway instigates the early life DR response to metformin. Stabilization of cellular ATP levels alleviates late life metformin toxicity in vitro and in vivo. Could you comment, please. Always interested in your input. Nancy McClure-Galli, M.D., MPH 21 Reply 1 reply Linda McNeil Linda McNeil 4 months ago Would the effect be synergistic or is there a point of diminishing returns. It sounds like you are finding your answer. What interesting questions. Great topic here. Reply 5DollarShake 5DollarShake 3 years ago I strength train mon/tues and thurs/fri , and I've recently added metformin on sat/sun to attempt to make me very insulin sensitive for when I push carbs on training days , I just began this experiment last weekend but I will soon see if my performance takes a turn for the worse or continues on its trend upwards 5 Reply 5 replies Richard Rivera Richard Rivera 3 years ago That’s incredible to hear, the point about healthy people who exercise taking Metformin. According to Dr. David Sinclair , who uses it personally in a study he is conducting within himself has stated that there is a synergistic effect. However, he understands that the pharmaceutical industry is the main cause of wrong dissemination of information. So who should we believe? I’m with Dr. Sinclair on this one. I am willing to conduct my own personal study under proper medical supervision. What do I have to loose? The potential to live 15% longer, healthier is a good incentive. 16 Reply 4 replies chris chris 3 years ago Can anyone correct me on this? As I understand metformin only blunts the muscle hypertrophy and the cardio-respiratory fitness effects of exercise. The other exercise health benefits, like increase in telomere length or decrease in body fat percentage are not blunted by metformin. Thanks in advance! 17 Reply 1 reply kineticx kineticx 2 years ago Very important questions answered, thanks for such informative talk Reply Victor Da Silva Victor Da Silva 3 years ago Good stuff dr Rhonda. I was taking Berberine with a fasting glucose of 95. I’m going to stop. Reply Rob Lovegreen Rob Lovegreen 2 weeks ago The body is so complex and it’s self regulating when it works right. When it’s not hindered by toxins or deficiencies and gets regular exercise and sunlight. 1 Reply Andrew W. / NH Andrew W. / NH 3 years ago Interesting finding....so Metformin potentially disturbs / upsets the Electro Chain Transport itself? Also the cardio AND lean muscle mass strengths reduction as side effects are particularly worrying.... Would combining Metformin and caffeine helps offset the AMPK inhibition? What about Chromium Pico or other insulin mimickers like Vanadium? Would be interesting also what happens if Metformin is used as TKD approach... 3 Reply Joel McCoy Joel McCoy 2 years ago Dr. Rhonda Patrick has upped the quality of the nutrition conversations of English speakers. This is great. 1 Reply Antique Action Figure Antique Action Figure 1 year ago I have been sick with Myalgic Encephalitis for 17 years now. Exercise is not an option for those of us with this disabling disease. I have just recently added metformin to my treatment routine. The keto diet was very effective in helping me lose the 75 pounds I gained when I got sick. Most of that caused by the exercise intolerance which is a symptom of ME. Even on a very strict keto way of eating by blood glucose is rarely below 100. It was much higher when I weighed 75 pounds more, along with my total cholesterol and triglycerides. Only time will tell if metformin will replace the 30 miles a week I ran and the 30 one arm push ups in my routine before I got sick. 2 Reply 6 replies Norwood reaper Norwood reaper 1 year ago Metformin and syrosingopine have been shown to work synergistically to work with each other to potently have an anti cancer effect. Syrosingopine also “was” a very good drug to also lower blood pressure. Why is it that syrosingopine is not even on the market anymore, it would be an awesome part of an anti-aging stack. Is it possible to request anti-aging websites like agelessrx to somehow source that I wonder🤔. Reply Michael Worley Michael Worley 4 months ago (edited) I'm jacked and cardio is amazing , been taking metformin for its health benefits for 7 years. ZERO impact on my fitness progression ,if there was a impact its miniscule . haha her acting like all these people are pushing themselves hard enough that metformin is going to have a serious impact and hold them back . Girl they got to get off the couch first , they got to get their diet in check first lol. Real life experience is sometimes better than information overload . 2 Reply Paul Beauchemin Paul Beauchemin 3 years ago Over the past 5 years I’ve smashed my shoulder and broken my hip while exercising both required surgeries and a year to recover. Will take the metformin thanks Reply 2 replies Ethan Cowart Ethan Cowart 8 months ago (edited) AICAR seems to have all the same benefits but is able to build muscle and maintain muscle even better. And doesn’t have the blunting effects on exercise. I think for healthy people that don’t have diabetes. Should use things like metformin few times a year to prevent diabetes. But just don’t use it to much cuz ur body can start to adapt I would imagine and u could have a mild dependence and/or rebound on it. So be carful. Reply JK JK 3 years ago Madam, I don't like cardio exercises(trademill,running, ellipticals).I do lot of bodyweight squats,pushups, weight-training,Yog,basic pilates. My query is : do the exercises I am doing give me increase in glucose,insulin sensitivity ?at present,I don't have diabetes, hypersensitivity etc.i am 63years,male,live in India. 3 Reply Brent McCulloch Brent McCulloch 3 years ago Berberine is often compared to metformin as a natural substitute, and some studies have show it's equally effective. I'm curious if berberine has these same non-synergystic effects with exercise as metformin does. 13 Reply 8 replies Ramil Magerramov Ramil Magerramov 3 years ago Thank you for this clip. Was just considering taking metformin. 17 Reply 1 reply Weygandt Weygandt 2 years ago I am a healthy 59 year old male who is not diabetic but am insulin resistant. I also see an age management Doctor who has been treating my Hypogonadism with Testosterone I.M. injections. I've been on Testosterone Replacement Therapy for 12 years and also work out on a regular basis. Working out with weights, I have strong muscle mass but always tend to hold on to 30 lbs around my body, most around my stomach. I am on a high protein diet and eat fibrous vegetables, omitting starchy carbs. When my doctor put me on Metformin it was a perfect fit for me. I lost 33 lbs in 3 months ( and now kept it off using Metformin for the past 3 years)...... I am around 9% body fat and very defined. It was the Metformin that worked for me along with diet and exercise......I am a believer. 2 Reply 14 replies 蔡哲光 蔡哲光 3 years ago 500mg metformin and 500mg niacinamide in the morning, moderate exercise and pre-breakfast exercise/stretch seemed work well for me! 17 Reply 4 replies Neil Sant Neil Sant 6 months ago Dr. RHONDA'S thought conclusion after analizing all trials is that "there is no substitute for EXERCISE". Though MEtformin really can help esp those who have pre/type 2 diabetes. 1 Reply Dave Larson Dave Larson 2 years ago I have a hunch that metformin combined with SAD is what causes the negative exercise results. Perhaps too much stress put open the systems. It’s like consuming fat: Works well when avoiding sugar and eating lots of leafy greens. A person’s diet should be a factor in a controlled study in future trials. In 5 years, excluding diet as a major factor in research might be no brainer. The reason it isn’t now??? 2 Reply 1 reply Ketogenicinfo Ketogenicinfo 3 years ago But, if you're chasing autophagy wouldn't Metformin and excersise be beneficial since they both inhibit MTOR? 13 Reply itd itd 1 year ago What if I've already improved my aerobic exercise capacity to my limit, then started to take metformin? 1 Reply David de Ridder David de Ridder 1 year ago Hi Rhonda, can you please do an update on Methformin. I really want to start taking something to increase lifespan. What is the latest knowledge on this front? 15 Reply 2 replies Iron Maiden Fitness Iron Maiden Fitness 11 months ago Would love to know if berberine has a similar effect while exercising 3 Reply crowdancer5 crowdancer5 7 months ago I thank you!!! I was seriously considering asking my dr for metformin......I am borderline diabetic and just dont want to go there......but want to coninue this life in a more healthy manner.......You have helped me to decide not to ask for it!!! AND, I have watched yu videos AND...listened to what you present s I trust where ou lead......just need to understand and know what is best or this body!!! Reply Sarah Bartlett Sarah Bartlett 1 month ago If you have insulin resistance or pre diabetes and are overweight - you SHOULD take Metformin to avoid getting diabetes!! The point is to keep the blood sugar down. Sometimes when you reduce weight you can reduce metformin. 1 Reply Andrés Grases Andrés Grases 3 years ago The interesting question (or answer for that matter) isn't "Should healthy people take metformin?". What I would like to know is "Are healthy people getting any NET benefit from taking metformin, compared to those who do not take it?" 7 Reply 2 replies Robert Carlson MD Robert Carlson MD 1 year ago Has anyone looked at using just a small dose of metformin combined with exercise? A healthy person without DM2 may not need very much to get mainly the good effects and minimize the bad... ??? Reply Engineere Pixlele Engineere Pixlele 9 months ago I fail to see how Metformin + Exercise is worse than Exercise if you are doing Exercise not caring about how much muscle you get but just for general health 2 Reply karel1331 karel1331 3 years ago Could you comment on Berberine? If the same negative effects are seen about the preventive gain in lean mass? 9 Reply 1 reply Bill99 Bill99 1 month ago But that large meta-analysis that she references here is incredibly persuasive. Metformin "reduces all cause mortality." So something very beneficial is happening. It seems that drawing contrary conclusions from very specific studies may be "missing the forrest for the trees." In other words, to achieve the "all cause mortality" result, Metformin probably has many benefits, the specifics of which are not yet known. So we've found some negative things. But they may be several things in a big stew that overall may be very beneficial. Reply Tessa Cyclone Tessa Cyclone 3 months ago (edited) hi Dr Rhonda Patrick. just my thoughts., Injured people cant exercise but still want to live longer. maybe , just maybe a lowish dose is benefitcial for these people, what do you think? Also at 8:45 . my comment - metformin blocks a certain perteage of Mtor being activated right? so yes it would reduce less muscle tissue being formed than in the group who werent taking it. Whats really interesting to me though is that the group on metformin who built less muscle didnt have statistical significantly less muscle strength. Its good that the mucsles arent weaker. Reply Mosax Mosax 2 years ago I train once a week (the right way to do it, Mentzer and Dorian Yates way) HIT fashion on very advanced resistance machines I have, and do fast walking the rest of the days of the week. I 'm planning to take Metformin 3 days a week (which are the ones I have a high carb diet) in between my HIT workouts, let's see how it goes. 5 Reply 2 replies olasaltasm olasaltasm 1 year ago Great video! Reply David Seva David Seva 11 months ago (edited) Thanks I have decided to stop taking metformin. Instead I will increase my exercise and take chromium picolinate, L carnitine and up my fibre intake. Reply Danovic Danovic 3 years ago I currently take resveratrol and berberine on days I don´t train. Resveratrol with some yoghurt. Waiting to take NMN once human trials show promising results. Reply Spoudaois Spoudaois 3 years ago I a nondiabetic take 2 gms per day but it took time to get there. 1 Reply Bobby Ocampo Bobby Ocampo 1 year ago How about SGLT2 inhibitors in relation with exercise? Reply Andreea Zamfir Andreea Zamfir 9 months ago what about the studies regarding gut bacteria and metformin? people with dysbiosis should take it? Reply all the chords and scales all the chords and scales 6 hours ago yes, but you forgot to mention that metformin increases your longevity by 15% Reply RainOnATinRoof RainOnATinRoof 2 years ago My igf-1 is too high. I've read that Metformin lowers igf-1. Would exercise lower igf-1 as well? 2 Reply 1 reply Edison Claro Edison Claro 3 years ago I took metformin for a couple of months ago and my exames do not show any alterations.I still at the same 2 Reply Martin Bruun Martin Bruun 2 years ago She sounds incredibly trustworthy! Reply 1 reply L. J. L. J. 8 months ago Her suggestion is to just excercise. That is true... but much harder for most than she is assuming. 1 Reply James Howlett James Howlett 3 years ago what about the study that actually REVERSED aging with metformin, GH, and another diabetic drug? 17 Reply 12 replies Altero Altero 3 years ago (edited) I was always against metformin as I'd like to keep my mitochondria healthy and working 100%. I believe that the way it helps people with diabetes is inhibiting energy production in mitochondria and making body to relly more on glycolysis, so it helps to better utilize glucose and make blood glucose levels lower. And it's not solution to a problem but a temporary fix. However in the long run in can help to live longer as overall inflammation levels would go down. But In healthy individuals with a proper nutritious diet I don't see any benefits of metformin. And as cardio exercises activate AMPK I don't think to activate AMPK even more with metformin is a good idea. The dose makes the poison. 9 Reply 2 replies Tim Tim 2 years ago Tanks for such particular topic. Find out answer for my direct concern about taking metformin during exercise circle. Reply Martin Nichols Martin Nichols 2 years ago Always seeking for a magic pill..... Eat low glycemic , do no overeat , exercise ( resistance and cardio) , manage your stress level and enjoy life ! IF , YOUR BLOODWORK INDICATES THAT YOU MIGHT NEED IT , THEN LISTEN TO YOUR DOCTOR ... 2 Reply birage birage 3 years ago Why not talk about methylene blue instead of metformin for mitochondrial energy? 2 Reply Bogdan-Gheorghe Cicioc Bogdan-Gheorghe Cicioc 3 years ago Cool, if I remember correctly Mr. Sinclair takes Merformin and exercises but only takes Mteformin in the off-days when not exercising. Any feedback ? Thank you 16 Reply 9 replies D 2row D 2row 3 years ago You're awesome! Reply Markus Antonious Markus Antonious 3 years ago No discussion of berberine, i.e. a natural supplement that largely mimics the good (blood sugar and anti-aging) effects of metformin...but without the side effects!? 12 Reply 4 replies Afraim Gershenzon Afraim Gershenzon 1 year ago Smart lady - but completely of the track. Starts with citing huge study of more than 70000 people increasing their life span by those taking netformin. Than she looses the point and starts to discuss the reduction in cardio capacity of those taking metformin. Clearly the training capacity of glucose reduction takers will be reduced. What's the big surprise...The issue was increasing the life span for type 2 diabetics-that is a very well established fact. By confusing the different aspects of metformin consumption the lecturer does a disservice to the audience. I am a MD with no diabetes at all and small iverweight. By taking 850mg daily lost 5 kg with no extra training and usual calory intake in 3 months. Feel great and more energetic. 6 Reply Rate MY Rate MY 2 weeks ago I take 2000 mg per day metfroming and trainng like a beast i lose 11 KG for 2 months I am beast in Fitness 2 hours cardio no problem Reply LaBambaC LaBambaC 3 years ago RP, from what you said, one might infer taking a smaller dose of metformin + exercise, or alternating exercise / metformin every few days.. ? also what about metformin in dm2 who exercise? 4 Reply 1 reply Hfc Tab Hfc Tab 3 years ago Oh wow Rhonda! How smart and clever right? No, not really - you take metformin strategically for healthy individuals - not on the days you exercise or fast. Both fasting and Metformin influence SIRT 1 gene expression - one of 7 sirt's which promote longevity. So if you fast - don't take metformin on this day, same applies to exercise - vigorous exercise, not just a 20 min walk in a park Reply Okironin Okironin 3 years ago Can u post the link to the study? 1 Reply andré Moraes andré Moraes 2 years ago An endless question! Reply Sawmiller Smith Sawmiller Smith 3 years ago I'm 71 and take no drugs and I would say I'm healthier than those who do I might die sooner though. Only time will tell. But in the mean time atlest I'm able to get around better than those on drugs. They need a study on people like me versus those on drugs. 11 Reply 11 replies David jones David jones 3 years ago I found 2 X 500MG MF a day killed my HIIT workouts and recovery. A real combo killer is a Statin and MF. What energy pathway is not being suppressed. 5 Reply 1 reply Ali Khan Ali Khan 1 year ago (edited) The reality is 99% of people do not exercise 150min per week and diabetes is number 1 killer since it affects every single organs of the body, heart, kidney, brain, eye, all blood vessels so we should be propagating to start metformin to average people instead of waiting until they develop diabetes. Regardless of all these fancy pathways and researches, at the end of the day, we need to figure out how can we slow down insulin resistance in general population. So main question is taking metformin prevent or delay developing diabetes or not ?? No diabetes = longevity. 2 Reply 1 reply Alexis Espinosa Alexis Espinosa 2 years ago Ok, Metformin is not synergistic with exercise! Then, What about Rapamycin? And what about fasting? I bet all three are not synergistic with exercise. But exercise cannot promote all the good effects these other three induce. What is known about this.?? Thanks a lot! Reply Bobby Ocampo Bobby Ocampo 1 year ago (edited) How about comparing exercise then Sauna with Metformin. Any Randomized Controlled Trial? Reply 1 reply Despair not of the Mercy of God Despair not of the Mercy of God 3 years ago Hi there, what do you mean exercise? What sort of exercise? How long?thank you. 2 Reply hogi99 hogi99 1 year ago (edited) She doesn't give specific degrees of the negative effects. Is it 1%, 10% or 90%? Just saying it negatively affects doesn't really tell you anything. Rats are a poor correlation to humans, it's better than nothing, but how much weight should rat studies be given? Reply 1 reply Yoso Yoso 3 years ago Living longer is not necessarily a good thing. Imagine being quite fat and unable to wipe your own ass for those last years, confined to a wheel chair always connected to your oxygen supply. Perhaps you don’t even know who anyone is anymore, including yourself! And all the while, watching those near your age walking at a healthy clip on by taking in the sun and the good lords air. Pharmaceuticals often do no make a healthy, vibrant person. 3 Reply 1 reply Sid Michael Sid Michael 2 years ago What are the natural alternatives for metformin benefits? 1 Reply 3 replies Val Brenneman Val Brenneman 2 years ago As a Type 2 diabetic who has been on Metformin since 2006 I have to ask..."Are you CRAZY??" 1 Reply 2 replies red berries red berries 3 years ago Interested in berberine. More easily available in the UK. 18 Reply 3 replies Yukon Jack Yukon Jack 1 year ago What if you're only 55 and used to be in shape but after 3 failed back surgeries with constant pain you can't get deserved pain meds cause idiots died so you put on 100lbs drink more than you should n go on Metformin we'll see how it works out.✌ Reply Elliott Rubenstein Elliott Rubenstein 1 year ago Thank you very much. Exercise bests metformin. Reply BizzyIzzy87 BizzyIzzy87 1 year ago What about if you are on TRT and taken metformin 1 Reply juan fermin juan fermin 3 years ago She let the Doctor say three words and that's it.. 1 Reply Splassshhh1234 Splassshhh1234 2 years ago Thank you! Reply danny iskandar danny iskandar 2 years ago so basically if you exercise is better NOT to take metformin ... You are taking the risk the eliminate the benefit of exercise by taking Metformin. So why David Sinclair is taking it? 1 Reply Native Roots Native Roots 8 months ago If your healthy than I wouldn’t … if you have type 2 like me then yes you need it if it works for you Reply Samuel Diaz Samuel Diaz 2 years ago Why athletes don’t live longer if exercise is ati-aging? 13 Reply 7 replies Fernando Almaguer Fernando Almaguer 2 years ago What if you take metformin on rest days. As well as IF 16:8 Reply 2 replies Stealth Machines Stealth Machines 2 years ago Thanks again! exercise good!metformin no so much! 4 Reply 2 replies bichillocv bichillocv 1 year ago Any one knows is DPP4 inhibitors do also inhibits mTORC? Reply Mr.GreenGold Mr.GreenGold 2 years ago How about supplementing with Beriberine? 3 Reply 1 reply Donnie Maclennan Donnie Maclennan 1 year ago I give up.There is so many contradicting videos out there on anti aging suppliments . Its just all too confusing 56 Reply 12 replies Youtube Iscruel Youtube Iscruel 1 year ago Can u state the p values or something so it doesnt sound like bs? Or is it? Reply Tibi Tibi 3 years ago Because Metformin lover the natural production of Testosterone(this is why u have no libido and make no gains) ! Berberine is healthier-no major side effects 1 Reply 4 replies Arth Denton Arth Denton 3 years ago Dr. Sinclair suggests that you take Metformin on the days you DO NOT EXERCISE and you do NOT take it on the days you do exercise. 39 Reply 16 replies Queenb_Eff Queenb_Eff 2 years ago So if I'm prediabetic , I should not be taking this? 3 Reply 1 reply Bret Jones Bret Jones 10 months ago I"m not sure you can state we don't really know what the side effects are. It's been around for decades. Reply FoundMyFitness Clips · 1 reply blaster91 blaster91 1 year ago so much Biology on aging happening. Make youre life last dont wait. build yourself a sauna and get it going Reply bichillocv bichillocv 1 year ago Which is a good anount of exercise he says lol, 2 and a half hours per week bro not per day Reply Hector Rey Hector Rey 3 years ago Can I take Berberine instead of Metformin? 3 Reply 3 replies Splassshhh1234 Splassshhh1234 3 years ago love you, Rhonda Reply Arunava Sarkar Arunava Sarkar 2 years ago Comments in this video proves one thing. Human stupidity and infinity has no limit - Albert Einstein. Reply rob coghan rob coghan 1 year ago (edited) How about barberine ? Reply Sci-fi Fantasy Girl Sci-fi Fantasy Girl 6 months ago It makes me so very sick and weak. Reply Rui-9-CS Rui-9-CS 1 year ago 💕❤️ Reply Native Roots Native Roots 11 months ago It keeps you young Reply Alexander Sverdlov Alexander Sverdlov 2 years ago How can you repeat the same question over and over and over again??? 3 minutes in, and still repeating the freaking question? Wow. Reply Simple Man Simple Man 10 months ago Metformin reduces testosterone though 1 Reply salar hz salar hz 3 years ago You have posed many open questions. And later you imposed your ideas on using or not using metformin. Here I should say what the heck! At leat say your references that we could check! Not random studies , in random years! 3 Reply FoundMyFitness Clips · 1 reply John J T John J T 2 years ago Me too Reply Gregory Joseph Gregory Joseph 3 years ago (edited) Wonder why David Sinclair takes it!? Wrote this without seeing the comment below. I agree that I would love to see some feedback actually from Dr. Sinclair himself. 1 Reply 2 replies Geo Fillingame Geo Fillingame 2 years ago type 2 diabetic here metforman just gives me the shits i will just croak before you health nuts lol Reply martin sinclair martin sinclair 3 years ago Interesting Reply HEAVYlit HEAVYlit 2 years ago if rowing...and i need to as a mindful tool.. i suppose no more metformin. there. now im sure. Reply Queenb_Eff Queenb_Eff 2 years ago What is the placebo she's talking about Reply TheJs12347777 TheJs12347777 2 years ago Untill yesterday I had not realised that Metformin in sewage system runoff is damaging the aquatic environment causing gender bending type problems. 3 Reply 1 reply Jasboy H Jasboy H 8 months ago Lowers testosterone 1 Reply G.D. Fraser G.D. Fraser 3 years ago Why not take Berberine, get the benefits of Metformin without the downsides? 2 Reply 2 replies Queen Bee Queen Bee 1 year ago (edited) Umm HELLO how can a healthy person even get a prescription for Metformin??? Please address this issue first ! Its all well and good to talk about it but just a reminder most of us arent doctors and cannot help ourselves to this medication 1 Reply e doc e doc 7 months ago at 0:58 Is she saying 15 or 50 Reply Grim Reaper Grim Reaper 2 years ago (edited) By this logic, high-level athletes should have a significantly longer lifespan than the rest of the population, but that ain't the case, now is it?? And 100-300 mg/ kg of body weight, are you fucking kidding me??!! Who the fuck takes that much?? Those who take Metformin for longevity purpose, barely exceed a daily dose of 500 mg, maybe 1 gm for some individuals but that's about it. Reply Brent Lancaster Brent Lancaster 1 year ago Can you please speak to berberine and exercise? - thanks. Reply Sid Michael Sid Michael 2 years ago How to activate ampk the best way? 1 Reply 2 replies Thomas O'Keefe Thomas O'Keefe 1 year ago Say no to metformin and take berberine instead. Much healthier. Reply ivan ivan 3 years ago No! Reply Ddd Nnn Ddd Nnn 1 year ago My God, your a pretty Lady.. 3 Reply Jim McIntyre Jim McIntyre 3 years ago Crap! Reply Nenad Cubric Nenad Cubric 1 year ago No Reply Spiros Koulouberis Spiros Koulouberis 3 years ago Bla, bla, bla... After 5 minutes, you still haven't told us if I should take Metformin, as I don't have diabetes type 2. 2 Reply 3 replies Nrml Nrml 1 year ago What a totally lame guest. She had no studies in front of her, was very vague, overstated and exaggerated. The way she presented, she could have facts mixed up and/or be making it all up. I suggest she pull herself together if she is going to make claims in such a vague way. Not credible at all. 1 Reply Reply