Sirtuins Anti Aging. Revisited. What they are. Why you should care. How you can benefit. Making Tomorrow Better, plus HA(hyaluronic a)cid

Sirtuins Anti Aging. Revisited. What they are. Why you should care. How you can benefit. Making Tomorrow Better 725 subscribers Subscribe 55 Share 658 views Jul 24, 2021 Sirtuins Anti Aging. Revisited Following up on my last sirtuins video I have added more information and an extensive list of what each sirtuin does, and what you can do to optimise yourself, and who you should be bothering. My videos for more detail. Exercise • How Exercise Can ... Sleep • How Sleep Is Impo... Sauna • Crazy Health Bene... Cold • Cold Showers. Ice... Diet • Fundamentals Of F... Fasting • Fasting Is All Th... Resveratrol • Resveratrol Anti ... Original Sirtuins • Sirtuin Activation Links to all articles I used to make the video Restoration of energy homeostasis by SIRT6 extends healthy lifespan https://www.nature.com/articles/s4146... SIR2 blocks extreme life span extension https://www.cell.com/fulltext/S0092-8... Resveratrol not direct activator of SIRT1 https://pubmed.ncbi.nlm.nih.gov/20061... Dietary Activators of Sirt1 https://www.ncbi.nlm.nih.gov/pmc/arti... Sirt 1 Mitochondrial biogenesis https://www.ncbi.nlm.nih.gov/pmc/arti... Activation of thyroid T3 hormone https://pubmed.ncbi.nlm.nih.gov/23922... Neurodegenerative diseases https://pubmed.ncbi.nlm.nih.gov/21902... Insulin resistance/diabetes https://www.ncbi.nlm.nih.gov/pmc/arti... Age-associated weight-gain https://www.frontiersin.org/articles/... Liver function & body homeostasis https://pubmed.ncbi.nlm.nih.gov/21638... Human embryonic stem cell differentiation https://pubmed.ncbi.nlm.nih.gov/21144... Sirt 2 Lower mitochondrial activity & fatty acid metabolism https://pubmed.ncbi.nlm.nih.gov/22302... Sirt 3 Oxidative stress https://pubmed.ncbi.nlm.nih.gov/21658... Low levels of SIRT3 insulin resistance & fatty liver disease https://portlandpress.com/biochemj/ar... Sirt 4 - Tumor-suppressive benefit. Mitochondrial glutamine metabolism and DNA damage https://pubmed.ncbi.nlm.nih.gov/23562... Reduce insulin secretion https://pubmed.ncbi.nlm.nih.gov/20729... Sirt 5 Mitochondrial metabolism &ammonia detoxification/removal https://www.cell.com/cell/fulltext/S0... Sirt 6 Genome stability & DNA repair. Low levels metabolic problems & age-related health issues https://pubmed.ncbi.nlm.nih.gov/20729... Sirt 7 rDNA transcription & DNA repair mechanisms https://www.cell.com/cell/fulltext/S0... SIRT7 Old/dormant hair follicles https://www.ncbi.nlm.nih.gov/pmc/arti... Sirt1 overexpression calorie restriction https://www.ncbi.nlm.nih.gov/pmc/arti... Sirt1 moderate overexpression inflammation, liver cancer, diabetes &hepatic steatosis https://www.ncbi.nlm.nih.gov/pmc/arti... Sirt6-overexpressing mice hypoxia & high-fat diet https://www.ncbi.nlm.nih.gov/pmc/arti... SIRT6 highly fatal form of pancreatic cancer https://www.ncbi.nlm.nih.gov/pmc/arti... Examples of NAD-boosting molecules include NMN, nicotinamide riboside https://www.ncbi.nlm.nih.gov/pmc/arti... Inhibitors of CD38 such as apigenin142, quercetin142 & GSK https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... Omega 3 Lower inflammation & oxidative stress https://www.ncbi.nlm.nih.gov/pmc/arti... Niacin energy metabolism https://www.sciencedaily.com/releases... Elevate NAD levels in muscle, blood and other tissues https://pubmed.ncbi.nlm.nih.gov/32386... Olive oil & sirtuins sirt 1 https://www.cell.com/molecular-cell/f... Polyphenols & sirt 6 https://www.nature.com/articles/s4159... Polyphenols & sirt 1 https://pubmed.ncbi.nlm.nih.gov/16603... Lifespan enhancing properties of sirt 2 - 1999 https://pubmed.ncbi.nlm.nih.gov/10521... Anti cancer properties https://pubmed.ncbi.nlm.nih.gov/20450... DNA repair sirt 1 helping to repair the double helix https://pubmed.ncbi.nlm.nih.gov/18835... Sirt 1 role in cellular autophagy https://www.pnas.org/content/105/9/3374 SIRT1 also supports mitochondrial autophagy, the detoxification of old cells & cellular renewal Sirt & exercise https://pubmed.ncbi.nlm.nih.gov/19549... High-intensity exercise or cold-exposure activates SIRT1 https://www.sciencedirect.com/science... Sirt & circadian rhythms https://science.sciencemag.org/conten... Saunas increase NAD+ & SIRT1 levels https://scholarcommons.usf.edu/etd/4567/ Cold exposure activate sirtuins https://www.sciencedirect.com/science... Key moments View all 10 Comments rongmaw lin Add a comment... Making Tomorrow Better Pinned by Making Tomorrow Better Making Tomorrow Better 1 year ago So what are you lifestyle and diet choices that you make then? Let us know if the comments.. 7 Making Tomorrow Better Reply Making Tomorrow Better · 1 reply Did Leo Did Leo 1 year ago It’s a very informative and interesting and well made video. Looking at the number of references you went through to produce this rigorous evidence based video, it’s impressive! Thanks for the effort and sharing the info that helps living healthier and for longer and making tomorrow better! 7 Making Tomorrow Better Reply Making Tomorrow Better · 1 reply Nige Stenner Nige Stenner 1 year ago Interesting video! I read The Sirt Food Diet book (Goggins and Matten) a few years ago and now incorporate a lot of the foods in my everyday diet. Is there a way to measure the levels of all the Sirtuins in our bodies (and also levels of NAD)? So that you can take a measurement, make some lifestyle/diet changes, then in a few months measure again to see if levels have improved? Otherwise, how can we tell that things are improving apart from how you feel, which is always open to interpretation and could be due to other factors? 6 Making Tomorrow Better Reply Making Tomorrow Better · SIRT6, FUCOIDAN & LONGEVITY: Will Activating SIRT6 Extend Your Life? [2021] Lance Hitchings 50K subscribers Subscribe 940 Share 16,975 views Jun 25, 2021 SIRT6 & FUCOIDAN: In today's video, we examine the new paper that just came out on activating SIRT6 and the supplement extracted from seaweed that activates it. We'll do a quick review of what sirtuins are and how they function before jumping into the new paper that was published last month on SIRT6. Prof. Haim Cohen and his team extended the lifespan of both male and female mice by as much as 27% (or over 30%, depending on who you believe). Then, after discussing the activation of sirtuin 6, we'll talk about Prof. Vera Gorbunova and a new supplement that she has discovered which she claims will do just that...activate SIRT6! Prof. Cohen's study has galvanized the longevity community, so join us as we take a deep dive into this innovative new intervention. Chapters & Timestamps: 00:00 Intro 02:21 Sirtuin In The News 04:08 Sirtuins: What Are They & How Do They Function? 10:00 SIRT6 Extends Lifespans In Mice 14:38 Activators Of SIRT6 17:01 Fucoidan & DoNotAge ************************************************************** LInks to studies in this video: https://www.nature.com/articles/s4146... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/28355... https://pubmed.ncbi.nlm.nih.gov/33308... https://pubmed.ncbi.nlm.nih.gov/33934... https://pubmed.ncbi.nlm.nih.gov/33684... ************************************************************** SOCIAL MEDIA LINKS: Facebook: https://www.facebook.com/lancehitchings/ Instagram: https://www.instagram.com/lancehitchi... Twitter: https://twitter.com/LanceHitchings ************************************************************** AFFILIATE LINKS: Discount code for DoNotAge: LANCE Product Links for DoNotAge: SIRT6Activator: https://donotage.org/products/sirtuin... Annual Subscription: https://donotage.org/subscribe/ Products : https://donotage.org/products/ Discount code for Alive By Science: LANCE10 Product Links: https://alivebyscience.com/all-produc... Discount Code for Perfect Amino: HITCH10 PerfectAmino Drink Powder link: http://affiliates.bodyhealth.com/idev... PerfectAmino Tablets link: http://affiliates.bodyhealth.com/idev... Chapters View all 165 Comments rongmaw lin Add a comment... Lance Hitchings Pinned by Lance Hitchings Lance Hitchings 1 year ago OK, I looked into this further. Fucoidan is not the name of a specific chemical substance, but rather the name for a class of substances. There are several different types of fucoidan, each with different molecular structure and different properties. Fucoidan refers to a type of polysaccharide that contains substantial percentages of L-fucose and sulfate ester group, but can also contain other monsaccharides, including mannose, galactose, glucose, xylose, etc. plus other compounds like uronic acids, acetyl groups and proteins. What type of fuciodan a compound is can depend on the type of seaweed that is was extracted from and the method of extraction, to name a few. Check out this page for a small selection of the different types of fucoidan: https://www.zenmony.com/types-of-fucoidan-f-u-l-g-ga-a27/ So, there are many different types of fucoidan, each with it's own distinct properties. In light of this, it's not too difficult to see why it can be so hard to find fucoidan that can activate SIRT6. Hope this helps. 30 Reply 2 replies Frank Lanham Frank Lanham 1 year ago CONGRATULATIONS Lance! I think your decision to create a longevity course and charge for it in order to support your work on YouTube is brilliant. Your current videos bring all the detail of the complex chemistry and biology of longevity down to a level of understanding better than anyone else on YouTube. I know it takes a lot of time and work to do that, and I’m glad to support you in your ongoing efforts. This will, no doubt, be a win-win for everyone. You get support and your audience gets a pre-digested source of understanding and information for the ongoing longevity research and the resulting practical capabilities being produced in this complex field. Here are two aspects of the course that I personally would like to see. First, I would really like to have the course content available in some “printed” form in addition to or instead of video. The amount of information involved and its complexity are very large, and just having a video to watch in order for me to mentally capture everything is not adequate. If only video content were presented, I’d have to spend a large amount of time taking notes and creating complex diagrams that I could use for study and review to ensure that I can confidently reason about what I should be doing to extend my own longevity. Ideally, the course would be presented both in video and in a printed format, such as PDF. If that were done, we students could view the video first to get the big ideas involved, and then study the text and diagrams to cement the details in our heads. Second, a hybrid of one-time purchase and a subscription model of pricing might work well. A person could buy the course to get the first version. The course would have to be updated occasionally, maybe on a quarterly basis, in order to keep up with the rapidly evolving field. So a person could either re-buy the course at full price whenever they think it’s worth doing, or they could subscribe to updates after they have purchased the full course so they could have lower cost access to the updates on a continuous basis. And if you really want to confuse everyone, you could also create two tiers of the course – one lower cost tier of video-only, and a higher cost tier of video and printed material. I’m not trying to tell you how to run your course, Lance; I’m just casting my vote for course features I’d like to see. However you do it, I’m sure it will be a major contribution to the many people who don’t have PhDs in this field but still want to understand it in order to extend their lifespan and healthspan. Thanks so much for doing this! 11 Reply Lance Hitchings · 1 reply StarryFolks StarryFolks 1 year ago (edited) Great job sir. Truly inspirational. Probably the coolest thing to do at that age. I just turned 20. Any advice would be wondrous, although this YouTube channel is more than enough...hope it grows virally. 2 Reply Lance Hitchings · 1 reply Sebastian Niemann Sebastian Niemann 7 months ago (edited) Thanks for the great video Lance🙏 Do you know anything about Life-Extension's Fucoidan? "Optimised Fucoidan with Maritech" Their website says you use the type of algae used in most scientific fucoidan studies. Maybe this is a slightly less expensive alternative?🖖 3 Reply Sisel International Sisel International 1 year ago Awesome information, thanks for the hard work and research you put into all your videos, Lance! We have a video in which we talked about fucoidan's activation of sirtuins and some other health aspects of fucoidan, as well. Would love to hear your feedback. Thanks! 3 Reply Lance Hitchings · 2 replies Stephen Connors Stephen Connors 1 year ago (edited) Great. As a newbie, there's a lot more I don't know than what I do know. Paying you for your knowledge saves me time and eliminates the wasted efforts. I look forward to it. 3 Reply Lance Hitchings · 2 replies Manuel Ojeda Manuel Ojeda 1 year ago You're doing a great job. 4 Reply David Vesco David Vesco 6 months ago Great lecture excellent information I will follow your podcasts Thank you 1 Reply Lance Hitchings · 1 reply Think Supersystemic Think Supersystemic 1 year ago Great video and I appreciate your pinned comment. Anyhow, there is one little piece of info missing: which type of fucoidan is the type that works? Any ideas, or is this unknown by everybody except those in Prof Gorbunova's lab? Reply Lance Hitchings · 1 reply David A David A 5 months ago Any human studies yet defined, and/or done for how well SIRT6 works on humans? Reply Zul O Curran Zul O Curran 4 months ago Genius as always.What about the other Sirtuins. What compounds can switch these genes. Reply stevem544 stevem544 1 year ago (edited) Excellent explanation of sirtuins, in particular, SIRT6. Thanks 5 Reply Lance Hitchings · 1 reply Zeropain Zeropain 1 year ago Great video lance. I've watched some of the other peoples videos and I was confused as well. And it seems like there is still some confusion remaining. I'm suspecting the researchers are now influenced by $$$ and might be making some less conservative claims. Thanks for sorting through all of this and boiling it down to 20mins. It must have taken you a long time! I'm going to wait a few more months for more coherent results. One question. If NMN activates all Sirtuins, why bother with Fucoidan? Or is it that NMN only activates the de-acetilysation part of SIRT6? 4 Reply Lance Hitchings · 2 replies Pluvo2for1 Pluvo2for1 1 year ago I wish I could afford it too Lance! Anyway the sirt info was nicely detailed thank you. I can see what Brad has given up on reservatrol as it seems to only activate sirt1. 3 Reply Lance Hitchings · 3 replies Paul Kiesow Paul Kiesow 9 months ago Hello Lance, I seem to be the only person using cyanidin as a SIRT6 activator—via ribosylation, as well. Have been taking 200mg daily for two months. Fucoidan can occasionally work at 'cross-purposes' methinks, yet cyanidin is potent and rarely an inhibitor. Thoughts please. 1 Reply Lance Hitchings · 7 replies Dan O'Hanlon Dan O'Hanlon 1 year ago Great job getting her information! Much appreciated… 2 Reply Lance Hitchings · 1 reply Tom Wallace Tom Wallace 1 year ago Once again, if a function is good for you, you can probably activate it fasting. Thanks for this video! 6 Reply 2 replies simon mojarad simon mojarad 1 year ago Hi Lance. Thanks for the work. Please provide a Patreon or other contribution link. Thanks! 2 Reply Lucky Lucky 1 year ago I think the Do Not Age Sirt6 activator may be a total scam. Somebody needs to do a third party test to see if it activates Sirt6. When the people making it and selling it are the same ones testing it there's a potential for fraud. There needs to be third party testing for this product and so far as I know there isn't any. 15 Reply 11 replies chris chris 7 months ago Great video for learning. I am like you, searching in sites for studens of pharmacy, biology and so on. I am reading books for students, and ... Ill have a look on your offer. By the way, Im in contact with do not age too, because I havnt an answer on my questions jet. They offered me a phone call which is really nice! Maybe I will try their product. Reply David A David A 5 months ago Hi Lance, I like your presentations. Please add to your information presented which (natural food) sources provide TMG. For example there is no reason for people like me who eat a steady amount of Wheat Germ, Beets, Spinach, Quinoa, to fork over $100 for TMG supplements, which I would venture to hypothesize are not nearly as bio available and surely not as broadly nutritious as the natural sources as follows: Here’s the amount of TMG found in a 3.5-ounce (100-gram) serving of several foods (24Trusted Source, 25Trusted Source, 26Trusted Source): Wheat bran: 1,339 mg Wheat germ: 1,241 mg Spinach: 600–645 mg Quinoa: 390 mg Beets: 114–297 mg Shrimp: 219 mg Wheat bread: 201 mg Keep in mind that several factors impact the amount of TMG found in foods. For example, certain cooking methods, particularly boiling, significantly decrease the TMG content . 1 Reply Michael Hason Michael Hason 5 months ago One problem I can point out, alpha ketoglutarate was suppose to increase lifespan by mildly suppressing ATP generation! Reply Glenn Thorn Glenn Thorn 1 year ago I have been taking this supplement from ,DO NOT AGE, I have noticed a big increase apatite over the past 3 weeks and lots of energy 7 Reply 4 replies Stephen Brown medialink Stephen Brown medialink 1 year ago The work you are doing is wonderful. Your course will be a great value. Sign me up. 2 Reply Lance Hitchings · 1 reply M G M G 4 months ago I took two capsules of Do Not Age Sirt 6 Activator and afterwards was taken to rhe hospital emergency. Got terrible stomach cramps that needed to treated with an infusion. They asked me what I had taken, I told them about the product. They never heard of it - of course. I am sure the cramps came.from the capsules. I never had pain like that before in my whole life. I won't take any of these capsules ever again. Even though, they were damn expensive. 1 Reply Olya V Olya V 1 year ago Thanks for your video. I would be interested to learn more about your course. 1 Reply Lance Hitchings · 1 reply Eisa A Eisa A 1 year ago Hi Lance, is there a requirement to take a NAD+ supplement along with this Sirt6Activator ? Thanks Reply Lance Hitchings · 1 reply Christopher Ellis Christopher Ellis 10 months ago (edited) SIR2in, 1-6 Mine must be working well. Began going to the gym for the first time in 40 years. Seems easier than before. Fucoitin? Reply Richard Breeze Richard Breeze 1 year ago (edited) Dark red pigments activate Sirt 6. For example berries ( elderberries in particular ) , red wine and Hibiscus tea. Imagine if Do Not Age managed to get a million people to buy Sirt 6 activator. So £ 1000 × 1 million. Yea , its " profitable " we could say that much with confidence. Who says you can't just eat seaweed. Oh hang on a minute ... 2 Reply 1 reply Deep Dusto Deep Dusto 9 months ago A great vid, though I have a beef with folks that stop talking about a one line of thought while saying, this is important but I will come back on this, but then they never do. You talked about: "Sirt-6 over-expression in low-IGF mice, where Sirt-6 did not affect lifespan in the female sex ... and I'll come back on this :)". I kept waiting but you never did. Uggggh. Reply ArticBlueFox96 ArticBlueFox96 1 year ago I don't know why none of these organizations have genetically engineered foods to produce significant amounts of the ideal form of anti-aging compounds, like fucoidan. 4 Reply 1 reply Antonio Marti Antonio Marti 2 months ago (edited) Evidentemente la extensión del 27 % en varones es sobre la vida media esperada que, en este sexo, es menor a la de mujeres. En cuanto a éstas, el 15 % de extensión o ganancia se daba sobre una esperanza de vida media superior a la de los varones. Cuando después habla de una extensión del 11 % para varones y un 15 % para mujeres ya no habla de vida media esperada sino de longevidad máxima o vida máxima conseguida sobre cada sexo. 1 Reply Lubna Habeeb Lubna Habeeb 3 weeks ago I bought the starter package including SIRT6 from the this company 8 or 9 months ago and I didn’t notice any positive difference. I get headaches and itching every time I take it and it has a fish smell. Did I receive a bad patch? Did anyone experience something similar? Reply Lance Hitchings · 2 replies Rodger Knight Rodger Knight 1 year ago Hi Lance: Thank-you for your work on this video - would you mind sharing the discount code for the DONOTAGE product - 1 Reply Lance Hitchings · 1 reply Hobby Farmer Hobby Farmer 1 year ago I am taking Okinawa Fucoidan made by Japanese company Kanehide Bio. 1 Reply ravern1000 ravern1000 1 year ago Personly I do not believe they are the only ones that sell the specific fucoidan that works,sounds like a money tree, considering it is a very cheap substance . 3 Reply Lance Hitchings · 1 reply William Perkowski William Perkowski 1 year ago median lifespan is how long most of the mice live. Max lifespan is how long the oldest mouse lives. If most mice live 48 months, then 30% increase is (48 x .3). If Max is 58 months then max is 58 x it's percentage increase. Thus max lifespan could still be higher than median lifespan notwithstanding the fact that median increased by a greater percentage value. 2 Reply Lance Hitchings · 4 replies Cedrick Kevin Nanini Cedrick Kevin Nanini 1 year ago im pretty interested in a course that will give me the understanding about longevity and apply them to be commercially be produced cheaply. best regards from the philipines Reply Lance Hitchings · 1 reply Ann Graves Ann Graves 1 year ago Great video Lance. Reply Lance Hitchings · 1 reply Scott K Scott K 1 year ago "I'm not sponsored by Do Not Age because I want to keep this channel unbiased..." "...but I am an affiliate." 1 Reply 1 reply François-Xavier Dubois François-Xavier Dubois 1 year ago Don't be stupid, everybody! The seaweed extracts in question cost almost nothing and are not patentable: in just a few months, the competing companies will have had the time to formulate exactly the same fucoidan extract for much less: which is why they want you are subscribing now for a year, at shockingly expensive prices, because they are the only ones on the market, but they know it can't last long... Nonetheless I really consider their brand is a very good one, especially for thieur apigenin at a very competitive price... Anyway, Thanks and thumb up, Lance, for the excellent review ! 3 Reply Lance Hitchings · 4 replies katty pan katty pan 6 months ago i guess the seaweed that japanese and korean people eat is not better than the special fucoidan 1 Reply Steven Lucks Steven Lucks 1 year ago 1st what is your code and 2nd what other products are available to use for SIRT6 Reply Lance Hitchings · 1 reply Gold Hunter Gold Hunter 1 year ago In capitalism the cure to high prices is......................high prices. I remember when quercetin cost a fortune - like spermedin does now. 2 Reply Erwin Rogers Erwin Rogers 1 year ago Wow 🔥 Reply Paul Wolf Paul Wolf 1 year ago Some fuciodan activates SIRT6, and other fuciodan supresses it, even though it's the same exact chemical. OK. 2 Reply Lance Hitchings · 2 replies Edison Claro Edison Claro 1 year ago please send more informations about your course. I will do . you are a very honest man. 2 Reply Lance Hitchings · 2 replies Manuel Ojeda Manuel Ojeda 1 year ago My life time is INVESTED in my PIANO. I LIKE YOUR INFO TO ESTEND MY LIFESPAN. Reply 1 reply it is me OK it is me OK 7 months ago to live longer do you have to take this stuff for the rest of your life Reply frank brown frank brown 1 year ago are we to take Ms. Gorbunova at her word or is there some evidence out there that Fucoidan supports Sit 6? 3 Reply 3 replies tran khang tran khang 10 months ago I ' m come form vn. Thanks Lance..!! Reply Joe Moya Joe Moya 1 year ago Hmmm... LANCE Discount code didn't change the price.... when I tried to order. {shrugs shoulders} Reply Lance Hitchings · 1 reply Popeye Seamaster Popeye Seamaster 1 year ago The discount code? 5 Reply Lance Hitchings · 2 replies z1fire z1fire 1 year ago Too rich for me as well Reply Lance Hitchings · 1 reply dlb dlb dlb dlb 9 months ago Lance your face age is not showing results Reply Lightbeing Pontifex Lightbeing Pontifex 1 year ago most fucoidan blocks sirtuin 6 what the,,,,, 1 Reply Lance Hitchings · 1 reply Don Coady Don Coady 1 year ago Elderberry 2 Reply 1 reply Sirtuin and How it Effects the Aging Process Dr. Ryan Shelton 65.7K subscribers Subscribe 224 Share 9,310 views Jun 24, 2019 CHECK OUT DR. SHELTON'S INNOVATIVE SUPPLEMENT LINE AND BOOST YOUR HEALTH!: http://www.ZenithLabs.com In this video Dr. Ryan Shelton discusses the aging process and how to slow it down. Find out about sirtuin and how it effects aging. ------------------------------------------------ SHARE THIS VIDEO: Sirtuin and How it Effects the Aging Process • Sirtuin and How i... TRY THE ANTI-AGING FORMULA LONGEVITY FORMULA https://zenithlabs.com/product/longev... FOLLOW DR. SHELTON: FACEBOOK: https://www.facebook.com/zenithlabs/ INSTAGRAM: https://www.instagram.com/dr_sheltons... SIRTUIN PATHOLOGY MASTER 7.72K subscribers Subscribe 35 Share 1,369 views Apr 3, 2020 CELL INJURY(IN GENERAL PATHOLOGY) This Video is about Sirtuin#Definition#Types#Effect On Health # Mechanism of Action Featured playlist 25 videos CELL INJURY(IN GENERAL PATHOLOGY) PATHOLOGY MASTER 8 Comments rongmaw lin Add a comment... John Sharnetsky John Sharnetsky 2 years ago (edited) A perfect explanation of a complicated topic. Great video. Thank you. 1 PATHOLOGY MASTER Reply PATHOLOGY MASTER · 1 reply Medicomate Medicomate 2 years ago Thank you sir for such kind of easy explanation.🙂 2 Reply PATHOLOGY MASTER · 1 reply RolandLab RolandLab 3 months ago Thanks for the video! Reply PATHOLOGY MASTER · 1 reply Aishwarya Purohit Aishwarya Purohit 2 years ago very nice explanation sir...thankyou 1 Reply PATHOLOGY MASTER · 1 reply 27% Longevity Extension? New Sirtuin-6 Research Fundraiser Dr Brad Stanfield 156K subscribers Join Subscribe 2.9K Share 49,897 views Jun 13, 2021 #Longevity #Healthspan #Sirtuins New research published in May 2021 shows a 27% extension in lifespan when an enzyme called sirtuin 6 is overactivated in mice. So what is sirtuin-6, what are the details of this study, and what am I personally going to do with supplements such as Fucoidan in light of this research? Thanks for watching, I hope you enjoyed the content and found it genuinely useful. Please consider supporting the channel by signing up to Patreon: https://www.patreon.com/bradstanfieldmd My supplement stack: https://drstanfield.com/my-supplements/ ✨15% Discount Code: BRAD ✨ • ProHealth: https://www.prohealth.com/collections... ✨10% Discount Code: BRAD ✨ • DoNotAge.org: https://donotage.org/products/ • Renue By Science: https://renuebyscience.com/?rfsn=5206... The other supplements I take are found here: http://amzn.to/3o2ULOV Join me over on Twitter: https://twitter.com/BradStanfieldMD Here are the links to the research papers referenced in the video: https://www.nature.com/articles/s4146... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/22367... https://pubmed.ncbi.nlm.nih.gov/27519... https://www.ncbi.nlm.nih.gov/pmc/arti... If you like this video please smash the thumbs up button, it really helps with the Youtube algorithm :-) #Longevity #Healthspan #Sirtuins The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel. Chapters View all 408 Comments rongmaw lin Add a comment... Peter Coderch Peter Coderch 1 year ago (edited) A couple years ago, I had my whole DNA sequenced for reasons unrelated to this. One of the things I discovered, which was brought to my attention both by the geneticists and my doctor, is that I inherited a very rare version of SIRT-6, where the protein kinase is catalytically overexpressed by several fold. The guy from the lab send me a "Congratulation!" card, because, according to him, that SNP was found in two supercentenarians, which is not a small number since supercentenarians, especially male ones,, are exceptionally rare. Then, I thought about my family and I realized that it might be true. My paternal great-grandfather smoked 2 packs of cigarette a day for 50 years, and he died at the age of 109, just 4 months shy of 110. His brother died at 98...from a fall. My grand-uncle is still alive at 103, still walks without a cane and his only complain is mild arthritis to his joints. My sister also inherited the SNP, but unfortunately for her it is not properly expressed in females. Then, I thought about myself and I realized that there are patterns. I am 41, and people consistently tell me that I look like I am in my early twenties. I have zero grey hair either on my head, face or body. And just a couple tiny wrinkles around my eyes when I smile. My blood sugar never goes above the low 90's, even if I eat ice cream. On the other hand, when I fast, my blood sugar is higher than that of a fasting normal person, but still below that of well-fed normal person. I've never measuired my IGF-1, but I have measured my GH level, and it is always at the bottom 20% of people. I even considered supplementing with GH because of this, but then realized that whatever benefit from GH I would just increase my cancer risk. It was always kinda weird to me that my blood sugar never dropped much when I fasted, and I would get thirsty as hell. But the primary effect of SIRT-6 is not metabolic, related to IGF-1 regulation. The primary effect is increased DNA repair, especially of double-strand breaks, the kind that causes cancer. That is probably why my great-grandpa smoked 2 packs a day for 50 years but never got cancer(maybe). He also loved hard distilled liquor, and never got liver or throat cancer either. SIRT-6 also upregulates telomerase to lengthen short telomeres, which probably helps with things like osteoporosis and sarcopenia, since it helps to maintain stem cells. But not everything are roses for me. The same genetic testing revealed that I did not inherit the protective SNP of FOXO3A, which is something I expected since I am over 6'3 tall. I also have the MET-MET version of the COMT gene, which probably explains why I am so anxious and agitated. In fact, my anxiety is so bad that I will probably not live very long. Stress is one of the things that most shortens life. So even though I inherited a "super" longevity gene that allows you to live over 110 years, I might actually die at 80 or 85 from being such a worry wart. Point is, we are all kinda mixed bags. Some blessed in some ways, some in other ways. My MET-MET COMT allele. for instance, allows me to concentrate, but makes me a nervous wreck. As a big guy, I also don't have the protective FOXO3A allele, and those alleles are the most consistent findings among centenarians. Maybe my ST version of the FOXO gene will carry more weight in determining how long I will live than my protective SIRT-6 allele. Who knows? The point is to be happy with what you have, and not be let down by things that are out of your control. 50 Reply 28 replies Vegans Rising Vegans Rising 1 year ago The particular Canadian kelp that I use as a condiment for my foods is about 13% fucoidian by dry matter. I think this is the best way to get it along with all of the other nutrients that are naturally occurring. 7 Reply 1 reply David Thompson David Thompson 1 year ago Great content Dr. Brad. Time last NIH study seemed contradictory or difficult to draw conclusions from. Too little quercetin and SIRT6 is down regulated, and then positive outcomes from some herbs used as inhibitors of SIRT6. Can your do a video explaining what doses of quercetin and the more potent activators and weekday a protocol might look like? Every other day, rotations, etc? Thanks! 6 Reply Terrance Moore Terrance Moore 1 year ago Thanks Brad for staying up to date as a Physician (most don't) and taking the time to keep us informed. I appreciate it. 1 Reply Davi Fernandes Alves Davi Fernandes Alves 1 year ago I've read about a experimental sinthetic compound used in human trial in Israel. The compound was engineered to target Sirt6. After 3 months most of the participants reduced more than 20% of liver fat and ameliorate several other markers of metabolism. 2 Reply Sebastian Andersson Sebastian Andersson 1 year ago Cyanidine is found in most red berries such as blueberries, blackberries, cherries, cranberries, elderberries, hawthorn, loganberries and raspberries, but also in other fruits including apples, pears, peaches and plums. The highest concentrations of cyanidine are found in the peel of the fruit. Seems like a safe way to activate sirt6 4 Reply Don Taylor Don Taylor 1 year ago I really appreciate that as a physician you have access to and are willing to research your topics as compared to other YouTubers in the anti-aging world who rely on bro-science or one guy in particular who obviously watches your videos and then shortly after puts one out using your well researched info. I am grateful for all you do and present in such a professional manner, Dr. Stanfield. 6 Dr Brad Stanfield Reply Dr Brad Stanfield · 8 replies Don Coady Don Coady 1 year ago (edited) Have any of the proposed SIRT6 supplements already been tested on mice? If so, I would expect the data would have shown a longevity boost? Thanks for another interesting video, please keep them coming! 4 Reply Greg Meissner Greg Meissner 1 year ago Thank you for another very timely and very level-headed look at recent research. Like you I'm following developments and not putting the cart before the horse; I'll continue with healthy lifestyle practices like exercise and plant-based nutrition while I watch to see where the research takes us. Part of that will be following your videos! Reply Johnny Johnny 1 year ago when it comes to leading edge/evolving topics I like to play it safe by incorporating naturally occurring substances, so Brad's mention of brown seaweed/algea got my attention. Looking into it here for a few minutes I am not sure what is the most cost-effective way to incorporate it. We have full spectrum brown seaweed, extract standardized to fucoidan, and extract standardized to fucoxanthin, maybe other options. No idea which way to go on this, would appreciate any thoughts. 5 Dr Brad Stanfield Reply Dr Brad Stanfield · 4 replies Martin Von WunderGass Martin Von WunderGass 1 year ago I'm going to take Spirulina and Olive oil. But what I really want to do is what I did in 2012, which was to take a combo of about ten different longevity tonics/ super herbs in conjunction with a high fruit diet. About 10 months in and the detox symptoms were gone, and I started feeling amazing. Two years in, I hit 40, but felt like 25 again. It was a wonderful feeling. I fell away from it for various reasons, but now I want that invincible feeling back again. Reply null null 1 year ago Thanks again Dr. Stanfield. I always enjoy your videos. I feel like you are on a research journey and inviting us to come with you. One of the only channels I hit the bell for. 2 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply John McEwan John McEwan 1 year ago It’s interesting that the blue zones’ diet is based on foods that we are now realizing have enhancing properties. Olive oil- oleic acid, seaweed - sirt6 activator, tofu - spermadine. 45 Reply 10 replies Andrew Taylor Andrew Taylor 1 year ago (edited) Interesting. I've stopped taking resveratrol for now, but still take 300 mg NR daily. PS: Tried hyaluronic acid again; had same problem as before - vertigo apparently caused by swelling of inner ear. HA appears to do a good job of increasing internal fluid levels, but I don't seem to have the space for it in my inner ear cavity. And my liver scores (ALT, AST) have gone from good to excellent with taking TMG and reducing the amount of beer... 3 Reply Mick Miah Mick Miah 1 year ago (edited) Hi Brad, very interesting vid bud. Do you have any idea how much Quercetin they are suggesting? I look forward to seeing further research cause 27% is a very good start! I will have enough extra lifetime to finish Joyce's "Dubliners". My strategy when taking supplements is only to take those things with proven effects, which is why your channel is so good, and to keep my supplement list down partly because of cost but also to to ensure I am not taking multiple sups for the same issue. I am excited to see the outcome of this research and at that point I will review my pills. 1 Reply 213chud 213chud 1 year ago Such a great channel, I always learn something. Thank you for everything you do Dr Stanfield. 8 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply soilworker soilworker 1 year ago Thank you for the video. Could you make an update of your daily supplements routine, what you are currently taking and when? That would be really helpful. Reply Karl F Karl F 1 year ago Thank you Dr Stanfield, I appreciate your videos and the effort and detail you take to share with us. I am somewhat new to my own efforts and research for longevity, I am currently 60 years old, started taking resveratrol about 3 years ago, then recently started taking NMN about 3 months ago, but recently stopped after you shared your research and I changed to take NR supplement instead of NMN, and I still take a pure form of resveratrol each day. I am very curios about DoNOtAge SIRT6 activator and I considering trying it, I am wondering though should I stop taking resveratrol given that studies have shown that increase in SIRT 1 along with increase in SIRT6 in mice did not have any longevity affect, only the SIRT 6 boost increased life span. So it seems that it would be a waste of effort and money to try to boost both SIRT 1 and SIRT 6 at the same time. Any feed back about that is appreciated. Anybody have any experiance with DoNotAge SIRT6 activator? I buy many other supplements from DoNotAge and I believe it is good quality, I am just wanting to supplement with the best products for my age. Thanks in advance. 1 Reply 1 reply Gary Z Gary Z 1 year ago Your balanced, thoughtful review and conclusions are ALWASY very helpful, thank you!! Dr Brad Stanfield Reply Brent Nally Brent Nally 1 year ago Awesome video as always! I started taking fucoidan recently but I’m taking too many other things to notice any changes. 27 Dr Brad Stanfield Reply Dr Brad Stanfield · 2 replies Phillip Hartman Phillip Hartman 1 year ago Oleic acid (olive oil), Fisetin (strawberries), and Quercetin (capers) are already part of my daily diet. I'm holding the line on aging pretty well. I barely have a wrinkle and I'm near 40. I've never felt stronger or energetic so I'm wondering when this "aging" thing is supposed to happen. 4 Reply Yo WaT Dafuq Yo WaT Dafuq 1 year ago Your channel is getting better and better !!! keep up the good work 👍 Looking for more update on sirt 6 research :) Reply Robert Newton Robert Newton 1 year ago Also, Dr. You may be Very interested in some of the literature regarding methionine restriction mimetic activity of the amino acid glycine. There have been a few studies showing some impressive lifespan increase in mice depending on the ratios of their diets of methionine to glycine 1 Reply - 神武 の Nightcore - - 神武 の Nightcore - 1 year ago (edited) I think the next question is why do sirtuins decrease with age and what are the side effects of altering those pathways? 2 Reply Creighton Freeman Creighton Freeman 1 year ago If oleic acid activates Sirt6 in vitro I definitely am going to continue eating my olive oil. It had earlier been reported to also activate Sirt1 more strongly than resveratrol does, and it is cheaper and does not cause the activation by oxidative stress as resveratrol does, so I see no down side. Also it tastes great with some balsamic vinegar on a salad..... 3 Reply Pluvo2for1 Pluvo2for1 1 year ago Thanks Brad. I was not aware of the importance of activating sirt6 as opposed to sirtuin 1. Reply Steven Langs Steven Langs 1 year ago There seems to be pretty strong evidence that oleic acid, e.g. olive oil, is very beneficial, and other molecules you mention are abundant in foods which are also part of the Mediterranean diet. I'll continue to consume those foods, and hopefully their benefits for SIRT6 will be shown in the future. 3 Dr Brad Stanfield Reply Dr Brad Stanfield · 5 replies Tomáš Knespl🇨🇿 Tomáš Knespl🇨🇿 1 year ago (edited) Do you consider making a video on whether we should supplement with vitamin B complex? In Czech Republic it's very popular to supplement with this but I'm not sure if I should waste my money on that. 2 Reply T Pike T Pike 6 months ago I already take Fisetin occasionally due to having Stage 4 colon cancer that had metastisized. But now I will take it when I have my chemo treatments which are currently a 3-day process every other week. I also plan to add Fucoidan to my supplement regimen, as well as increasing foods that help activate other longevity pathways. Reply 1 reply Eyes of Ibad Eyes of Ibad 1 year ago Keep up the good work! End aging once and for all :( we deserve a choice of how long we want to be alive 2 Reply General B General B 1 year ago (edited) I’m waiting for more research and instead loading up on Olive Oil that’s packed with Oleic acid. Also sticking with NMN and my 24-72hr water only fasts. Also been stepping up my weight training and HIT routines and getting plenty of sleep. I still have a lot of quercitin and fisetin left but after they run out i won’t be reordering anytime soon. But it’s great to see the sirtuin research is going full steam ahead and im anticipating some really good findings in 2022. 1 Reply Dr Brad Stanfield · 3 replies James Fortune James Fortune 1 year ago I'm going to take one Resveritrol pill per week until they're gone, hoping I get some cell stress benefit. I'm doing parsley with breakfast, including extra virgin olive oil on salads, taking K2 with D3, aswagandha, co-Q10, and keratin. I didn't find any TMG locally, so I'll have to order online. I'm also exercising more. My gray hair seems to have reversed a little. I have little to lose, and there seems to be little risk, so I'll try this a while longer. 1 Reply Brian Meadows Brian Meadows 1 year ago Dr. Brad, I would like to see you review/study NAC (glutathione) as an antioxidant and life extending supplement. Thank you. Reply gary gjl gary gjl 1 year ago Looking into epigenetic blood tests. I asked my resdient last friday to do an IGF1. mtf. Oleic acid is on board everyday. Hmm fucoidan. I'll keep searching for further education. Great info again. very grateful sir. Reply Wm N Wm N 1 year ago I have been taking 500mg nicotinamide mononucleotide with 200mg resveratrol daily. I'm 55 now so it's going to be a while before I know if it's had any effect. Lis Parrish used gene therapy to start the gene responsible for telomerase production that is showing promise. It's nice to see aging thought of as treatable, time will be the ultimate test. Maybe CRIPR will prove effective enough to enable aging to be edited out of the cell? Reply Moldovan Sebastian Moldovan Sebastian 1 year ago Hello Dr Brad, as I was watching videos about this topic I've heard D. Sinclair saying the yeast has 5 sirtuins, not 1, and we have 7. Video here: Anti Aging Doctor's Key to Looking Younger | Joe Rogan minute 3:12. I give this as a reference, not an advertisement for another channel, but it's a clip relevant to yours. Btw, I've seen you and subscribed and look forward to more videos. Thank you 4 Reply Ron Hooft Ron Hooft 1 year ago (edited) What about sirtuin 2 3 4 5and 7? ;) Anyway, you mentioned oleic acid. I already eat 2 or more tablespoons of olive oil per day, and one small avocado. So hopefully that helps 3 Reply chuck becker chuck becker 1 year ago (edited) Purely by coincidence, I already take these supplements and EVOO, & mixed green seaweeds but for their other alleged benefits. I even was taking a much higher dose of Quercetin before being admonished about it having a risk for thyroid function. All is good so far. 5 Reply 3 replies Fabien Dass Fabien Dass 1 year ago Way to go, Dr. Brad! I think I will contact "Do Not Age" for the Sirt6 activator. Can you tell me if it is correct that it comes from seaweed and is potentially a strong part of the Japanese diet and the Japanese do tend to live a long life? 2 Reply 3 replies - 神武 の Nightcore - - 神武 の Nightcore - 1 year ago Can you make a video about inducing Yamanaka factors - I wish people would do more research into them Reply blaine bowling blaine bowling 1 year ago Recently I've seen sirtuin -6 mentioned in articles and comments and was wondering what the hype was about. Interesting and exciting... Yes. In vitro is miles away from human efficacy though. I'll be waiting with baited breath for the proof! I so hope it's true. But for now I'm going to stick with the best available evidence... Thanks for the free education Doc'! You're the BEST!! Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Cole Mctarmach Cole Mctarmach 1 year ago Great video and awesome channel. I might start taking these molecules sometime in the future. Hopefully sooner than later. 1 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Ronny André Wilhelmsen Ronny André Wilhelmsen 1 year ago I wonder if you can add or include as a rule the metabolic pathways that are implicated in either the supplements or the food containing the active substances leading to longevity. There is some logistics here at play in the biochemistry that isn't communicated or elucidated. I am referring to the timing, availability, processing, storing, delivering, repeating, clearing, cleaning up and reusing, either the substance with its quality and quantity - or body. So the key logistical elements involved in longevity. Reply Michael Gebhart Michael Gebhart 1 year ago (edited) Already take quercetin for NAD+ boost via CD38 inhibition & switched to higher quality olive oil for cooking & salad dressing so this is great news. Reply Dan O'Hanlon Dan O'Hanlon 1 year ago Extraordinary video! Thank you — much appreciated… 1 Reply 1 reply Norah Linehan Norah Linehan 1 year ago Hi brad, i have a question i think You might be able to answer. Can you take a lot of suppliments together. Im hoping to take carnosine, carnitine berberine and a multivitamin together. Could they possibly interact negatively with one another. Hoping to take after dinner daily.Would appreciate your imput. Reply Jim Gordon Jim Gordon 1 year ago You remain a truly honorable and humble person…so rare. I say this due to many reasons but most notably your references to getting ahead of yourself on Resveratrol. 34 Dr Brad Stanfield Reply Dr Brad Stanfield · 3 replies D Dutton D Dutton 1 year ago Totally confused because in the abstract of the following recent paper they say that fucoidan is a SIRT6 inhibitor. "A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer's Disease, Aging, Cancer, Inflammation, and Diabetes". But in the body of the paper they say that fucoidan is an activator. We will have to see what those wealthy rodents think. 3 Reply Darkhorseman82 Darkhorseman82 1 year ago Certain Cyandins activate Sirt6 while decreasing CD38. Though genetic repair in humans is a synergy between Sirt 1 and 6. I tried linking a study, but youtube just deletes comments with links to studies. 3 Reply Levon Darratt Levon Darratt 11 months ago Is there any new data on this in spring of 2022? Seems like do not age as corn at the market with the third six products but there has to be some other evidence of all this? Great video, we are awaiting your further analysis. :) Reply 1 reply Pedro Flores-Villanueva Pedro Flores-Villanueva 2 weeks ago Very interesting! Cyanidin is the most potent SIRT6 activator. SIRT6 is a deacetylase enzyme on histones, modulating gene expression. SIRT6 is also a mono-ADP-ribosyltransfarase and may restore adequate homologous recombination lost with aging. However, prostate and breast cancer cells express SIRT6, and it seems to confer increased proliferation to those cancer cells. Thus, mire studies are needed to clarify this issue. Reply Ken Otwell Ken Otwell 6 months ago I'm already taking taking fisetin and quercetin, so I'll wait on new evidence before spending the high price for the donotage sirt 6 product. Thanks for the great reporting! Reply 1 reply art Steale art Steale 1 year ago I will do the same as you. Keep learning from you and others about all the research Reply Chris Acosta Chris Acosta 1 year ago Great job Doc. Reply ifoundthistoday ifoundthistoday 1 year ago you can wait for more trails to be conducted because you have your whole life ahead of you ... I'm your dad's age even though I'm health as can be for my age I would like for all this research to advance in months not decades 1 Reply fly on your screen fly on your screen 1 year ago (edited) i'll be taking quercetin(+bromelain) as a hyaluronidase inhibitor, cd 38 inhibitor and sirt6 modulator. Not sure what the upper limit is to dosage so will be taking the maximum recommended dosage for now. 1 Reply 4 replies Wazka Wazka 1 year ago I'm confused by the comment on your supplement stack that you want to take NMN rather than NR. I thought you were saying that if you were to choose one, it'd be NR. Is there a video on this? 1 Reply The Ancients Ancients The Ancients Ancients 1 year ago DR Stanfield my favourite AI Android doctor 😍 13 Dr Brad Stanfield Reply JOHN BARRY YALLAGHER JOHN BARRY YALLAGHER 1 year ago I think that if the fucoidan extract has additional advertised benefits such as iodine supply then take it as it should do no harm. I am thinking of water extracted Fucus vesiculosis extract which is second place to the fucoidan extract that appears not to be readily available. Reply John Ely John Ely 1 year ago Thanks dear Brad. Keep us posted. Reply איתמר קגן איתמר קגן 1 year ago It seems that calorie restriction is the best way to enhance health and lifespan 1 Reply Jeff Schultz Jeff Schultz 1 year ago I have all of them for health benefits, usually take bioflavonoids b4 gym. What is a high does of quercetin? I was thinking of just shotgunning them in lower quantities. Thanks for sharing! 1 Reply MOONOOM MOONOOM 1 year ago Awesome Video Dr. S!🙏🏼 Reply ChuckleberrySoup ChuckleberrySoup 1 year ago Any chance we can get a Dr Brad review of the research on C-60 (Bucky Balls) affect on health & longevity!? Reply MisterFeathers MisterFeathers 1 year ago Could you do a Video about Carnosine and it's Anti Aging Effects? Especially through raising Carnosine by Ingestion of Beta Alanine 13 Reply 1 reply David G. Johnson David G. Johnson 3 months ago (edited) The jury is still out on the brown algae substance called Fucoidan to activate Sirtuin 6 as different batches of brown algae has different levels of Fucoidan, or none. Also the only company that processes the algae and sells the Fucoidan only allows their own labs to do the testing. Reply 1 reply James Lester James Lester 1 year ago Looks promising, of course I will wait for further research. 1 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Davi Fernandes Alves Davi Fernandes Alves 1 year ago I also read something about the effect is Fluvastatin on Sirt6 overexpression Reply dani moh dani moh 1 year ago Hi Brad. Which of the mentioned supplements would you recommend? How do they compare? Reply Dr Brad Stanfield · 1 reply M Jordan M Jordan 1 year ago look at the cerule stem cell ultra and the research they have on there website. the product releases your own adult stem cells into the blood where they can turn into almost any cell in the body with full length telomeres. Reply gregg bambu gregg bambu 1 year ago I take cuercitin. But not sure if the 500mg daily is better than a hit and run aproach of 1gram or more a day for 2 days out of the month. 1 Reply Robert Newton Robert Newton 1 year ago Dr. Stanfield, I noticed you now supplement niacin instead of NMN. Given that, which form of niacin have you chosen? Some forms of it are said to inhibit Sirt 1. There is niacinimide AKA nicotinimide. Inositol. and Nicotinic acid. Reply 1 reply Thomas Balle Thomas Balle 1 year ago pre-ordered it together with a bio-age kit. so i will know in a half year to a year if it does enything. Im allready on a great diet a lot of hiit. Had a lot of doubt but gonna take a shot on this one. 3 Reply LithaMoonSong LithaMoonSong 1 year ago I already use olive oil daily, we make organic popcorn and dress it with olive oil, low sodium soya sauce and nutritional yeast, a yummy treat and a good way to up our oleic acid. I think the benefits of olive oil have been proven by the longevity of populations in regions where olive oil is a diet staple. 1 Reply 4 replies Michael Snedeker Michael Snedeker 1 year ago This is fantastic Reply David Haggerty David Haggerty 1 year ago I already take quercetin and Fucoidan but maybe I should be taking Fisetin 1 Reply Patricia Swenson Patricia Swenson 1 year ago I will keep taking trans resveratrol, but will be looking to your further info on the new possible supplement. Reply Harold Beckala Harold Beckala 1 year ago I have been taking quercetin for 20 yrs due to allergies... maybe I was lucky to have these allergies 1 Reply 1 reply Bruce Sharman Bruce Sharman 1 year ago Fortunately I have a few macadamia, olive and avocado trees that give me a year (every day) supply; as well as egg laying hens. If I am in my 60’s so if I am still alive in 40 or 50 years I will let you know! 😬 2 Reply Lloyd Dupont Lloyd Dupont 1 year ago I am going to try Fucoidan, it's quite cheap.. and usually me eyes tell me if something good is happening, as in whether they ache or not and whether sight is slightly better or not... 2 Reply Rui-9-CS Rui-9-CS 1 year ago Fucoidan most likely would work...I remember new studies are coming out in 6 months. Reply 1 reply Marco Marco 1 year ago The pure unfiltered olive oil shots I've had all these years, (we make our own olive oil) haha must be why I have f!@# all grays at 50, (a few on my beard that you can count). Most think I'm somewhere between my late 20's to mid 30's. Not too brag. Of course all healthy foods combined that I've been eating which have certain acids that science is now discovering are perhaps responsible for activating sirtuins. Yes baby! 1 Reply 1 reply Vasudha Naidu Vasudha Naidu 1 year ago (edited) Sometimes I do not understand whether you will suggest anything is good at all for longevity at the end of the day.☺ 1 Reply Christopher Ellis Christopher Ellis 1 year ago I am waiting to hear about the affects of the microbiome, in that if one were to feed certain elements of it, benefits would result. The supplement approach keeps being revised, so I would look at the actual in vivo system first. 2 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply bob lolo bob lolo 1 year ago Did they use synthetic resveratrol? 1 Reply Fuuuk the Establishment Fuuuk the Establishment 1 year ago Have you heard of fenbenzadole curing cancer? Does it work for additional longevity? Would love to hear your thoughts and research! 1 Reply Henry Bee Henry Bee 1 year ago Nitro-oleic acid activated sirt6 by 40 fold at 20um (compared to just 2-fold by oleic acid alone.) Reply 1 reply MrBurkj MrBurkj 1 year ago cyanidin is thought to be a Sirt 6 activator... highest concentration in black elderberry.. readily available Reply V I V I 1 year ago AKG seems to have a lot of promise according to your interview with Dr. Kennedy. Can you do a video on that? 3 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Yvonne Sanders Yvonne Sanders 1 year ago Any information on fulvic acid? 1 Reply Jack Lingenfelter Jack Lingenfelter 1 year ago more research is needed on different rodents , as per Dr. Bret Weinstein’s findings, the breeding protocol for laboratory mice has led to their telomeres being lengthened, allowing them to heal extremely quick, but all dying of cancer eventually. It’s hard to translate research from mice to human , none the less, its all very interesting . Reply Peter Fodor Peter Fodor 1 year ago Hi Brad, i understand that when in autophagy, some of your senescent cells are recycled into new cells. Does this mean that you will also have new telomeres in the recycled cells? 2 Reply 1 reply Miguel mejia Miguel mejia 1 year ago how do we get sirtiuin 6 through diet or naturally? Reply P J Freeman P J Freeman 1 year ago I think I’ll wait to take Surtuin 6 until you show that the research supports it for humans. Thank you. Reply Take The Red Pill Take The Red Pill 1 year ago already consuming EVOO in every meal so more reason to keep doing that. Also, remembering to eat the spicy seaweed strips from the local Asian Market is not a problem Reply IvanAndreevich IvanAndreevich 1 year ago Looks like the theoretical underpinnings of olive oil are becoming better established. Make sure you buy the real olive oil though, not a fake. Costco Extra Virgin is decent value and has been independent lab tested to be legit. Reply bob person bob person 1 year ago So, then Resveratrol doesn't work, because it only activates Sirtuin one? Reply François-Xavier Dubois François-Xavier Dubois 1 year ago Very interesting. 👍 Reply Mark O'Leary Mark O'Leary 1 year ago I just read that fluvastatin, an FDA-approved synthetic statin is a SIRT6 activator Reply 3 replies Sawmiller Smith Sawmiller Smith 1 year ago Guess I'll wait. At 72 I'm healthier than the vast majority my age who are still alive. I have a cabinet full of supplements I take sometimes. 13 Dr Brad Stanfield Reply 14 replies Unholy Quail Unholy Quail 1 year ago Funny enough all the molecules you named are very much present in people who eat a plant based diet. Quercitin in Apples, onions, green leavy veggies. Fisetin in starbarries, apples, tomatoes and nuts. Fucoidan like you mentioned in green sea vegetables. And oleic acid in avocaod's, olives and olive oils. These all point towards plant sources. And no wonder a Mediterranian diet might be so good since all these foods are also very present in that way of eating. SIRT6 another argument for a more plant based livestyle. 2 Reply 8 replies Ray Price Ray Price 1 year ago (edited) You gain 27% lifespan, but because you're always hungry it feels like you gained 54%, so it's a double-win. 🤣 Reply Stephen Kwak Stephen Kwak 1 year ago Where can I buy Fucuidan? Reply Natnael Belay Natnael Belay 9 months ago At what age do you believe it is best to take the Fucoidan supplement? Reply 1 reply Coptercowboy Quadcopter Coptercowboy Quadcopter 1 year ago I have been drinking about 15ml of olive oil a day for several months now so was encouraged when I saw you mentioned oleic acid. is 15ml enough to activate sirtuin 6? I also take a few teaspoons of dried parsley and do some intermittent fasting. 4 Reply 3 replies Gary Danilkiewicz Gary Danilkiewicz 1 year ago (edited) How about remdesivir is that good for us it only had a 46% death rate when combined with a ventilator ? Also i heard nac a promising intravenous amino acid combo has good results but its much cheaper and nitric oxide is good a precursor might be arginine or maybe niacin not sure ?also i heard niacin is an anti viral although not widely known ? Reply 1 reply Reg Handford Reg Handford 1 year ago I don't trust mouse and yeast models. I think they can show almost anything the researcher wants to see or say. To avoid nasty side effects, wait for more proof of efficacy. 3 Reply 2 replies Native Elite Music Native Elite Music 1 year ago Definitely going to wait Dr Brad Stanfield Reply rfbead321 rfbead321 1 year ago ketovore diet + IF + HIIT + resistance training + good sleep + low stress = my recipe for long health span 5 Dr Brad Stanfield Reply Dr Brad Stanfield · 7 replies Barre86 Barre86 1 year ago wow your channel grows fast! proud to be one of the first x) 3 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Keith Haken Keith Haken 1 year ago ✌️another good one Doc Dr Brad Stanfield Reply Joe Silkwood Joe Silkwood 1 year ago WhooooHoo!!!! If it's a natural food source I'll take it NOW ideally as food :)!! BUT Never touching any synthetic mimics with a million foot pole 1 Reply Khalid Elgoudi Khalid Elgoudi 1 year ago What are the best supplements for alzheimer's? 2 Reply 1 reply AIM AIM 1 year ago So is there no benefit to oleic acid then? It's a SIRT1 activator isn't it? 3 Reply 2 replies Robert Newton Robert Newton 1 year ago does fasting activate sirtuin 6 at all? 1 Reply Natnael Belay Natnael Belay 9 months ago So the oleic acid is a transcriptional activator for the sirtuin 6 gene? Reply 1 reply Jerry Kroth Jerry Kroth 1 year ago Would it be logical or permissible to put Reservatol, oleic acid, fucoidan, and quercetin together into a big fat pill. jk Reply Being Frank Being Frank 1 year ago I AM TAKING SOME,AND ADDED FINESTIN< THANKS TO YOUR VIDEO! Reply cindy c cindy c 1 year ago what type of food should we eat to increase SIRT6 Reply 1 reply mike b mike b 1 year ago Where can I buy nr in Australia Reply mark veen mark veen 1 year ago (edited) Elderberries should be a good SIRT6 activator because of cyanidin, only problem is they also have cyanide when fresh. You can cook them ofcourse. But it might be that the hormetic effects get lost... 2 Reply 1 reply Cool Dude is cool Cool Dude is cool 1 year ago Wouldn't higher igf1 increase metabolism? 1 Reply Dr Brad Stanfield · 1 reply Jtrade Jtrade 10 months ago Since this video have you heard of any more scientific results for sirt6 Reply 1 reply The Ultimate Reductionist The Ultimate Reductionist 1 year ago While I praise all the hard work of scientists and think this research is important, simultaneously we cannot ignore the evil of forcing mice to suffer & die for it. 3 Reply Stephen Kwak Stephen Kwak 1 year ago Any low price fucuidan I can buy? Reply Paul Cohen Paul Cohen 1 year ago IGF-1 seems to be the key, not surtuin-6. A plant-based diet reduces IGF-1 to healthy levels while the standard meat-munching diet increases it to cancer-promoting and rapid aging levels Reply Royal R Royal R 1 year ago I am taking olive oil daily. Will wait for more human trial. Reply Indy Bryan Indy Bryan 1 year ago Olive oil and plenty of it 💪 3 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Lucía G.C Lucía G.C 5 months ago Do you know anything new about It? I really want to know if there is new publish results. Regards from Spain :) Reply 1 reply Dan O'Hanlon Dan O'Hanlon 1 year ago Fantastic! Thanks… Reply 1 reply Graham Fleming Graham Fleming 1 year ago I am on nmn oleic acid(extra virgin oil) metformin and occasionally parsley oregano or basil before I was partially crippled by two strokes I walk with a little limp are things good, yes I work six days a week! Does it work? I would say so. Reply 1 reply Gary Dinmore Gary Dinmore 1 year ago For me best to source these molecules thru whole plant base foods until further research. Low risk and no side affects. 7 Dr Brad Stanfield Reply Dr Brad Stanfield · 2 replies Simon Che de Boer Simon Che de Boer 1 year ago Can anyone recommend a good Sirt 6 activator? Preferably not donotage Reply 1 reply Careful, You’re projecting Careful, You’re projecting 1 year ago I’m going to become a mouse given the results Reply Karen Edwards Karen Edwards 1 year ago Mynmnexperiment dr Sinclair comments upset me totally supporting your comments and bravery Dr Brad Stanfield Reply R. Guerreiro R. Guerreiro 1 year ago By now I'll keep on my 30 ml of olive oil I already take with the fat soluble vitamins 2 Reply 4 replies Toshi Bytes Toshi Bytes 1 year ago (edited) take a shot every time he says sirtuin Dr Brad Stanfield Reply Mark Ferris Mark Ferris 10 months ago Research papers on Gynostemma also known as the herb of immortality Reply 1 reply Richard Malone Richard Malone 1 year ago I take extra virgin olive oil every day. Reply Joe Smeets Joe Smeets 1 year ago (edited) 👍👍👍👍🖖 Dr Brad Stanfield Reply Scotland The Insane Scotland The Insane 1 year ago Interesting, but it's another study that points to the benefits of simple caloric restriction... 2 Dr Brad Stanfield Reply Dr Brad Stanfield · 6 replies joe hurst joe hurst 1 year ago We've all seen " The Green Mile " now we know what really happened. Reply 1 reply Sharon Rachman Sharon Rachman 1 year ago (edited) I come from Sirtuin 6 planet🤖 1 Reply ceugantful ceugantful 1 year ago now how we can become mice ? 🤔😁 Reply Vasudha Naidu Vasudha Naidu 1 year ago Hello doctor. You seem to destroy every every longevity substance discovery be it Rasvetarol, NMN, or NAD. What is that will help to live a healthy long life? Reply 1 reply Gpcola 04 Gpcola 04 1 year ago Already use olive oil...in my mayo i use on my tuna. Quercitin and Ficiten...will have to review but think you advocate like apgenin we get these from fruits and vegetables...the stack is lengthy...guess research is needed. 1 Dr Brad Stanfield Reply Dr Brad Stanfield · 2 replies Dr. Delaney on Dreams Dr. Delaney on Dreams 1 year ago DEEP DIVE REQUEST, Dr. BRAD: Reply Lightbeing Pontifex Lightbeing Pontifex 1 year ago (edited) but fucoidan blocks sirt6,, unless its a certain kind,,, ie; sirt6 activator,,, Reply 1 reply Viracocha Viracocha 1 year ago I need to add seaweed into my diet!! Will any seaweed work? Reply Michael Snedeker Michael Snedeker 1 year ago Thanks Reply TT Fan TT Fan 1 year ago Epigenetics tells wich genes to switch on or off Reply Scott Keefe Scott Keefe 1 year ago So circling back. Do like Popeye; Eat olive oil. 13 Dr Brad Stanfield Reply 3 replies fred lacroix fred lacroix 1 year ago why keep quoting resveratrol if you already said that taking posed more danger than benefits? 4 Reply 6 replies Álvaro Baqué Álvaro Baqué 1 year ago Iron makes people aging Reply Android Son Android Son 1 year ago I do pesto italia souse with add of laminaria. Reply Jeff Morabito Jeff Morabito 1 year ago I thought it was 30% Reply Bill Arthurs Bill Arthurs 1 year ago Two and six Don't buy much these days Reply Brian Wilson Brian Wilson 1 year ago I'd like you to have David on Reply tuffduty tuffduty 1 year ago I’m listening! Reply Sawmiller Smith Sawmiller Smith 1 year ago I'll wait tell you interview doctor Sinclair about it. 6 Reply Dr Brad Stanfield · 4 replies David Doron David Doron 1 year ago Thanks, just wait. Dr Brad Stanfield Reply Splassshhh1234 Splassshhh1234 1 year ago 67 cant wait Reply Pana Liv Pana Liv 1 year ago Meh, rhodiola and ashwagandha outperform it🤷‍♂️ Reply alphamale3141 alphamale3141 1 year ago I do like this fellow but this video did not provide me with any actionable information. Reply SP95 SP95 1 year ago I don't want to eat seaweed salads 😢🍽 1 Reply Pete Pete 1 year ago (edited) Interesting but insufficient data to leap onto the bandwagon. A well know company has started supplying fucoidan on an expensive subscription basis. How do we KNOW that this substance has no deleterious effects? Do we KNOW that the longevity effect on mice translates to humans ? I will wait and see... Reply Dr Brad Stanfield · 2 replies Jack William Atkins Jack William Atkins 9 months ago I’m a million miles ahead of you. Reply 1 reply dlb dlb dlb dlb 9 months ago I already started Reply 1 reply jerrydesu jerrydesu 1 year ago Torture yourself. That's my recipe. Hot 🔥 Cold❄️stress, exercise, fast, unprocessed food. You may not live longer, but it will sure feel like it :) Reply Nico Effem Nico Effem 10 months ago 27% extended lifespan - well.. good - but quality of life is important and so is the ability to live independently with a full pack of sandwiches.... being demented and having another 15 odd years due to science does not seem so attractive, eh? Reply 1 reply Peterson Carlos Peterson Carlos 1 year ago Wait, of course Reply 1 reply Eoghan Hynes Eoghan Hynes 1 year ago Meadian != mean Reply Emma Emma 1 year ago Is Japan release radioactive water from Fukushima to the ocean ? seaweed may be not safe to eat . 2 Reply 1 reply Mo Nika Mo Nika 1 year ago HEI 1 Reply HARNESS84 _ HARNESS84 _ 1 year ago I snort nmn every day 2 Reply Hamid Hamid 1 year ago First. 1 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply C L C L 1 year ago I think sincerely you drop the ball on Resveratrol and on other sensational title like NMN produce cancer. Seems you make your Channel the channel of the anti David Sinclear I sincerely don't watched as I did before 1 Reply 1 reply SIRT6 Activator & NMN Users' Feedback | Alan Graves Ep 3 Modern Healthspan 37.5K subscribers Subscribe 274 Share 5,087 views Aug 20, 2022 #DoNotAge #NMN In this video Alan talks about some of the feedback they have had from their community of the SIRT6 activator and NMN as well as some background on where the SIRT6 activator came from and the testing process. Alan Graves is the CEO of DoNotAge.org a health supplement and research company which has the stated mission of extending healthy lifespan for as many people as possible. With that let me start the interview. DoNotAge.org home page: https://donotage.org/ 10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/ Renue By Science 10% of all products: https://tinyurl.com/4yrf4tv3 20% Discount at InsideTracker: https://insidetracker.sjv.io/DVmqkn Code HEALTHSPAN20 If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5 *********************************************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to legal@wevideo.com. ************************************************************************* Other Supplements that we take First thing in the morning Vitamin C 1g – California Gold Nutrition https://iherb.co/tjmJCSKv D3/K2 – Thorne - https://iherb.co/GYkP4T5b Life Extension, BioActive, Folate & Vitamin B12, 90 Vegetarian Capsule https://iherb.co/viDytpH Renue By Science, Liposomal CaAKG 90 300mg capsules - https://tinyurl.com/29j5pfcd Renue By Science, Lipsomal Glutathione 90 130mg capsules - https://tinyurl.com/yc6dxk34 Equal Exchange, Organic Coffee, French Roast, Whole Bean, 10 oz (283.5 g) https://iherb.co/hqfF23y Midday Renue By Science, Liposomal NMN 90 250 mg Capsules https://tinyurl.com/3wr8pr3t Pure NMN Powder 100g https://tinyurl.com/ys4hxwyf PURE Resveratrol Crystalline Powder (100 Grams) https://tinyurl.com/54dbnpmy NOW Foods, TMG, 1,000 mg, 100 Tablets https://iherb.co/hjsroit Celery Seed, 505 mg, 100 VegCaps https://iherb.co/BvKGp8p2 BioGaia, Osfortis with Vitamin D, 60 Capsules https://iherb.co/wJ14LbC Life Extension, TMG Powder (Trimethylglycine), 1.76 oz (50 g) https://iherb.co/WG88uUZ Celery Seed, 505 mg, 100 VegCaps https://iherb.co/BvKGp8p2 NOW Foods, Quercetin with Bromelain, 120 Veg Capsules https://iherb.co/8hbZ6DB NOW Foods, Turmeric Curcumin, 60 Veg Capsules https://iherb.co/uwHg6SU California Gold Nutrition, Immune 4, 60 Veggie Capsules (FIRST TIME BUY $1 – LIMITED OFFER) https://iherb.co/xAL12AX California Gold Nutrition, Lutein with Zeaxanthin, 20 mg, 60 Veggie Softgels https://iherb.co/hHRwBE5 California Gold Nutrition, Astaxanthin, Astaliff® Pure Icelandic, 12 mg, 30 Veggie Softgels https://iherb.co/YqWcvJ3 NOW Foods, Ashwagandha, Standardized Extract, 450 mg, 90 Veg Capsules https://iherb.co/Hv2h2Jz During the Day Krill Oil – EPA/DHA – Bullet Proof Krill Oil - https://tinyurl.com/m64fwcsn - Please use code HEALTHSPAN15 at checkout Bulletproof Innerfuel - https://shop.bulletproof.com/products... - Please use code HEALTHSPAN15 at checkout NOW Foods, Organic Acacia Pure Powder, 12 oz (340 g) https://iherb.co/wyfAnQi NOW Foods, Psyllium Husk Powder, 12 oz (340 g) https://iherb.co/9kYZ7bg Dr. Axe / Ancient Nutrition, Bone Broth Protein, Vanilla, 17.4 oz (492 g) https://iherb.co/4Pktm4C Dr. Axe / Ancient Nutrition, Bone Broth Protein, Pure, 15.7 oz(446 g) https://iherb.co/2p16DWU Dr. Axe / Ancient Nutrition, Multi Collagen Protein, Gut Restore, Lemon Ginger, 8.4 oz (238 g) https://iherb.co/bBf4osj Evening Liposomal Apigenin - https://tinyurl.com/3esd726x Liposomal HLA - https://tinyurl.com/4bhjfwc3 Magnesium Breakthrough - https://bit.ly/3O5tPfu Life Extension, Melatonin, 3 mg, 60 Vegetarian Capsules https://iherb.co/Mbz2JxV #DoNotAge #NMN #AlanGraves Key moments View all 58 Comments rongmaw lin Add a comment... Modern Healthspan Pinned by Modern Healthspan Modern Healthspan 7 months ago If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan DoNotAge 10% off all products Code MODERNHEALTHSPAN https://donotage.org/products/ Alan's interview playlist: https://tinyurl.com/2279thh9 4 Reply Yuval Kapellner Yuval Kapellner 7 months ago (edited) I have been giving nmn to my pets. Quercetin as well. I have developed my own protocol for several years. Nmn Quercetin and pqq helped me extend the life of my now late pet. My cat had severe chronic kidney failure. She passed at 20 years of age. I was able to help her live a much better life as well as extending her life. 2 other pets i have are on quercetin and nmn as well. They are healthy. 14 Modern Healthspan Reply Modern Healthspan · 10 replies Sparkling Sake Sparkling Sake 7 months ago Very interesting! thank you Richard! I'm impressed the questions you asked. 5 Modern Healthspan Reply Modern Healthspan · 1 reply Sharapova M. Sharapova M. 6 months ago Great to know so many positive feedback. Seems NMN has more obivous effect? Reply Scott Summerill Scott Summerill 6 months ago I just placed a large order with DNA. The delivery was surprisingly fast! That said, I have no clue how much of the supplements I'm taking. The units are non standard at least in this country. Is there a conversion calculation available? No idea why they chose what they did. My only complaint! Modern Healthspan Reply Modern Healthspan · 3 replies Battery9876 Battery9876 7 months ago One thing I'd like to know is if in Okinawa they were drinking green tea. Catechin with the gallate moiety is a sirt6 inhibitor, so I wonder if EGCG wouldn't counteract fucoidan and be a bad thing for longevity. I believe that green tea is good more for health span than life span. Epicatechin I believe from a study I read is less of a problem than catechins with the gallate. Perhaps that's one of the reasons why Jeanne Calment lived so long, because chocolate contains epicatechin. 2 Modern Healthspan Reply Modern Healthspan · 1 reply Peter Milian Peter Milian 7 months ago Why the focus on fucoidan over other promising compounds like black elderberry extract / cyanidin? Also, is there any advantage to taking a SIRT6 activating supplement if you're already consuming a whole food diet rich in oleic acid (pecans, almonds, flaxseed etc) which is known to activate SIRT 6? 2 Modern Healthspan Reply Modern Healthspan · 4 replies Rhonda M Rhonda M 7 months ago Reviewing your supplement schedule I do not see Fisetin listed. I believe you were taking it previously. What is your reasoning for discontinuing it? Modern Healthspan Reply Modern Healthspan · 2 replies Rich Ireland Rich Ireland 7 months ago Hello Rich long time no see even longer View, I'm wondering if you can give me any advice on good quality NMN. I see lots of different prices on Amazon but what I don't see is a label I should be looking for because I simply don't know of one. I have a physical assessment coming up for work which includes cognitive testing under physical strain. So I'd really like to know which brand you use or you could recommend please. I'm very aware of the efficacy of the supplement largely through your videos, but as mentioned I haven't watched for some time and I can't remember which brands are known quality NMN. Fascinating info that NMN improves your vision that really is interesting about retinal senescent cells! Hope Hong Kong is treating you well great to see you again, very interesting guest! 1 Modern Healthspan Reply Modern Healthspan · 7 replies BTC TO $1,OOO,OOO,OOO,OOO,OOO BTC TO $1,OOO,OOO,OOO,OOO,OOO 7 months ago Does he take his 2 grams at one time or does he spread it out throughout the day 1 Modern Healthspan Reply Modern Healthspan · 1 reply Martin Von WunderGass Martin Von WunderGass 6 months ago How much NMN is in Broccoli sprouts? Reply 1 reply A T A T 7 months ago 1:36 Notice how he completely dodges the question about the science behind it and very reasonable inquire about why would the same plant species yield such a different results depending on the “batch”... It all makes no sense whatsoever but sure, lets worry about lowering consumer price first…make those lab tests cheaper…this is such a disappointing interview on so many levels. 5 Reply 9 replies Ron M Ron M 7 months ago Thank you. Modern Healthspan Reply Modern Healthspan · 1 reply David Boyle David Boyle 7 months ago How much reveterol should you take per day SIRT6 ACTIVATOR® REVIEW | Sirtuin 6 Life Extension Supplement | DoNotAge & Vera Gorbunova The Anti-Aging Channel 6.01K subscribers Subscribe 101 Share 1,275 views Jan 5, 2023 SIRT6 ACTIVATOR® from DoNotAge is the only proven Sirtuin 6 activator supplement available. A successful collaboration between DoNotAge and world renowned longevity professor Vera Gorbunova. Longevity researcher Ryker Black reveals all you need to know about this amazing new life extension supplement. 10% Discount Code: RYKER https://donotage.org/products/sirtuin... Studies Referenced: https://www.sciencedirect.com/topics/... https://www.nature.com/articles/s4146... https://pubmed.ncbi.nlm.nih.gov/27836... https://www.frontiersin.org/articles/... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/31995... https://pubmed.ncbi.nlm.nih.gov/12651... https://www.nature.com/articles/s4146... https://pubmed.ncbi.nlm.nih.gov/33920... https://pubmed.ncbi.nlm.nih.gov/29260... https://pubmed.ncbi.nlm.nih.gov/28109... https://longevity.technology/news/lon... 16 Comments rongmaw lin Add a comment... carole Farrand carole Farrand 2 months ago This is my favourite anti aging channel, just keeps getting better with every new video. Im definately going to buy this supplement for my husband and I. 2 The Anti-Aging Channel Reply The Anti-Aging Channel · 1 reply Steven Green Steven Green 1 month ago Ryker I am loving your videos. You fill in details that other creators leave out. Thanks! 1 The Anti-Aging Channel Reply The Anti-Aging Channel · 2 replies Leonard Zemlinsky Leonard Zemlinsky 2 months ago (edited) Can we clarify if fitting of SIRT6 activating batches is actually tested and verified by Vera Gorbunova lab? This is a very strong argument to the validity of the supplement and it would be good to have it formally confirmed. And thank you for very informative videos! Reply The Anti-Aging Channel · 3 replies Eric Graves Eric Graves 2 months ago Another very well informed video - thanks 2 Reply Moi Suir Moi Suir 1 month ago Isn't the elderberry puree by biona cheaper? Tbsp a day Reply Phil Rouse Phil Rouse 2 months ago Thanks for posting 1 Reply The Anti-Aging Channel · 1 reply Darren Rose Darren Rose 2 months ago Your hair is looking really bright and vivid and BLONDE. Is this natural or through the use of a supplement? Hope you don’t mind me asking. 1 Reply The Anti-Aging Channel · 2 replies Why SIRT6 Contributes To A LONGER LIFESPAN? | Dr Vera Gorbunova Clips Reverse Aging Revolution 39.5K subscribers Subscribe 349 Share 6,006 views Aug 2, 2022 #PQQ #Quercetin #DavidSinclair Dr Vera Gorbunova presents the findings on researches about long lived species and centenarian. What contributes to a longer lifespan behind them in this clip. According to Dr Gorbunova, other than SIRT6, Dr David Sinclair, Dr. Manuel Serrano are working on yamanaka factors, which is another type of epigenetic rejuvenation. Sirtuin 6: linking longevity with genome and epigenome stability https://pubmed.ncbi.nlm.nih.gov/34281... SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species https://pubmed.ncbi.nlm.nih.gov/31002... LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation https://pubmed.ncbi.nlm.nih.gov/30853... Vera Gorbunova is an endowed Professor of Biology at the University of Rochester and a co-director of the Rochester Aging Research Center. Her research is focused on understanding the mechanisms of longevity and genome stability and on the studies of exceptionally long-lived mammals. Dr. Gorbunova earned her B.Sc. degrees at Saint Petersburg State University, Russia, and her Ph.D. at the Weizmann Institute of Science, Israel. Dr. Gorbunova pioneered comparative biology approach to study aging and identified rules that control the evolution of tumor suppressor mechanisms depending on the species lifespan and body mass. Dr. Gorbunova also investigates the role of Sirtuin proteins in maintaining genome stability. More recently the focus of her research has been on the longest-lived rodent species the naked mole rats and the blind mole rat. ___________________________________________ DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes. #SIRT6 #longevity #epigenetic #Rejuvenation #HealthyAging #DavidSinclair #Sirtuins #Epigenetic #Mitochondria #ALA #Metformin #PQQ #CoQ10 #Carnitine #Antioxidant #LookYounger #NMN #Resveratrol #Quercetin #Fisetin #senolytics #OliveOil #Sirtuin #HIIT #Resveratrol #aging #Lifespan #NMN #NR #Spermidine #Metformin #Berberine #ReverseAging #Epigenetic #OleicAcid #NMN #NAD #Fasting #Longevity #RestoreYouth #Reprogramming #DavidSinclair #DrSinclairLab #Healthspan #Younger #antiaging #DrSinclair #NAD #longevity #Bioscience #Epigenome #davidsinclair Key moments View all 22 Comments rongmaw lin Add a comment... Reverse Aging Revolution Pinned by Reverse Aging Revolution Reverse Aging Revolution 7 months ago THE MOST POTENT NATURAL SIRT6 Activator https://youtu.be/FbzFBld080A TOP 10 FISETIN Containing FOODS https://youtu.be/TKqwP95MKVA 22 NMN SUPPLEMENT BRANDS, ONLY 3 Meet What The LABEL CLAIMS https://youtu.be/rLROlP1kgOQ LIVE TO 100 – DOS & DON'TS https://youtu.be/GXbgyQejEqc NMN vs NR For Boosting Our NAD Levels https://youtu.be/hj5WmkY02h8 WHY Intermittent Fasting May Help Us To LIVE LONGER https://youtu.be/qhoqDsgzoJo 5 Supplements To Enhance Our Mitochondrial Health https://youtu.be/gR4IDhGmfPc WHAT NATURAL FOODS Contain QUERCETIN? https://youtu.be/mdgsIEOFgqE WHY Would OLIVE OIL Turn On Our LONGEVITY GENES? https://youtu.be/XP8SQu2_O7M 1 Reply Susan C. Susan C. 7 months ago I remember Dr. Sinclair said in one of his interview, SIRT6 has more potential than SIRT1 for extend lifespan. Mechanisms of Longevity: Lessons from Long-Lived Mammals with Vera Gorbunova, Ph.D. UR Medicine 6.99K subscribers Subscribe 71 Share 1,941 views Dec 7, 2021 Vera Gorbunova, Ph.D. is a Doris Johns Cherry Professor of Biology and Medicine and is co-director of the University of Rochester Aging Research Center. Her research is focused on understanding the mechanisms of longevity and genome stability and on the studies of exceptionally long-lived mammals. Her work has received awards from the Ellison Medical Foundation, the Glenn Foundation, the American Federation for Aging Research, and the National Institutes of Health. Gorbunova gave the inaugural lecture of the newly established Dean’s Lecture Series on Dec. 6, 2021. The series is intended to showcase high caliber research and high impact topics in clinical medicine and related biomedical fields. The presentations will be targeted to a broad audience of investigators and trainees from multiple areas of clinical medicine, public health, and life science research, as well as for interested members of the university community and the public at large. The George D. and Freida B. Abraham Foundation are sponsoring this series. Get information on future lectures here: https://www.urmc.rochester.edu/smd/ab.... Chapters View all 3 Comments 6 Reply 1 reply Gabriella Besso Gabriella Besso 7 months ago I would LOVE to give it a try, but it's too expensive for me 🥺 I wish you could sell the smallest size with like 60 capsules in it...... 1 Reply Abdelilah BENAHMED Abdelilah BENAHMED 7 months ago Olive oil (genuine not fake) activates SIRT-6. 10 Reply 3 replies WM P WM P 6 months ago Important and interesting Reply Raul Macias Raul Macias 7 months ago LOl Love the sock analogy. 3 Reply 1 reply Jason P Jason P 7 months ago @10:08 what molecule/compound in seaweed is she talking about? 2 Reply 5 replies Debasish Borthakur Debasish Borthakur 6 months ago Can CRISPR-CAS9 technology help building muscles in old people?? Reply Ticketforlife Ticketforlife 7 months ago a correction, whales are not the longest living animals, that goes to the Icelandic shark that lives up to 500 years, and probably more. Also I think that we need to figure out WHEN to activate sirt6 WHEN to deactivate mTor. In my opinion, the WHEN question that creates a net with all the longevity factors, is important. 1 Reply 2 replies Hyaluronic Acid & SIRT 6 - From Animals To Humans | Prof Vera Gorbunova Interview Series Ep4 Modern Healthspan 37.5K subscribers Subscribe 597 Share 13,211 views May 25, 2021 #Longevity #hyaluronan #SIRT6 In this video we discuss with Professor Gorbunova what how we can translate what we have learned from long lived animals into treatments for people. We discuss hyaluronan and SIRT6. Vera Gorbunova is a Professor of Biology at the University of Rochester and a co-director of the Rochester Aging Research Center. Her research is focused on understanding the mechanisms of longevity and genome stability and on the studies of exceptionally long-lived mammals. Dr. Gorbunova pioneered the comparative biology approach to study aging and identified rules that control the evolution of tumor suppressor mechanisms depending on the species lifespan and body mass. Her work received awards from the Ellison Medical Foundation, the Glenn Foundation, American Federation for Aging Research, and from the National Institutes of Health. *********************************************************************************** If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan AUDIO COPYRIGHT STATEMENT: Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to legal@wevideo.com. #Longevity #hyaluronan #SIRT6 Chapters View all 40 Comments rongmaw lin Add a comment... Modern Healthspan Pinned by Modern Healthspan Modern Healthspan 1 year ago If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan Professor Vera Gorbunova Interview Series Playlist https://www.youtube.com/watch?v=HmTOszMOWUI&list=PLkfzM7KJv6vb4qLHRh7Vax9Sb61JjZRqA Professor George Church Interview Series Playlist https://www.youtube.com/watch?v=mztOFAQf8uY&list=PLkfzM7KJv6vbRs8trUv-BmslHN5VvRRuX Modern Healthspan Newsletters Playlist https://www.youtube.com/watch?v=wNeuqs15JcQ&list=PLkfzM7KJv6vbSidsFjo7EAiryL7xtr7dg 2 Reply Richard Alty Richard Alty 11 months ago Vera is listed as an advisor for DONOTAGE, and specifically mentioned in their HYALURONIC ACID supplement description. In this video she appears less than convinced that taking such an oral supplement is going to be beneficial. The best she can say is it won’t harm you …I personally would need a better recommendation from a leader in the field before purchasing a hyaluronic supplement. Weird that DONOTAGE make mention of her in connection with their hyaluronic acid supplement. 10 Reply 5 replies Dizzy Cactus Dizzy Cactus 1 year ago I've found hyaluronic acid to relieve my GERD and subsequently most of my heart palpitations (which would flare up anytime my stomach is irritated). Been a surprisingly useful supplement, just started it for joint protection. 15 Modern Healthspan Reply Modern Healthspan · 4 replies DIYDSP DIYDSP 1 year ago Im impressed w how you interview real researchers! 8 Modern Healthspan Reply Simsam Malinao Simsam Malinao 1 year ago The contents are excellent. Please write summaries to clarify speech problems. 4 Modern Healthspan Reply Marcus J Marcus J 1 year ago Good video 👍🏻 Thanks for sharing 🙏🏻 2 Modern Healthspan Reply leo bezhanishvili leo bezhanishvili 1 year ago Thank you 🤍 So this awesome woman thinks same as Dr. Katcher, that our system is perfectly balanced but the epigenetic information messes up when we age. 14 Modern Healthspan Reply John Ramos John Ramos 6 months ago A little confusing, does Hyaluronic Acid act like Fucoidan or not for Sirt 6? Reply Rui-9-CS Rui-9-CS 1 year ago SIRT 6 is way hotter than SIRT 1, but we currently don't know which compound activates it safely... 4 Reply Benjamin Steele Benjamin Steele 1 year ago What about liposomal hyaluronic acid? This form is sold on the market now. But one can easily make it at home. Liposomal form delivers directly into cells. That is different than non-liposomal hyaluronic acid when taken orally that gets broken down. 2 Reply 1 reply Peter Peter 1 year ago So, it would make sense to identify the enzyme(s) that degrade hyaluronan and look for natural interventions which are, to some degree, inhibitory. Conversely, are there lifestyle habits which increase production fo enzyme(s)? Off to search PubMed and Vera's papers.... 1 Reply Stephany Gates Stephany Gates 9 months ago Made me wonder if HA might help the gut biome, thereby benefiting the entire organism. Reply 0dq0 0dq0 1 year ago Please release a video with your opinion about connection of hyaluronic acid and cancer 5 Reply 4 replies John Vogt John Vogt 1 year ago The Professor mentions bacterial derived Hyaluronic acic and another derived from (I could not understand what she says the other is). Can you clarify? 2 Modern Healthspan Reply Modern Healthspan · 3 replies Ron M Ron M 1 year ago Thanks. Modern Healthspan Reply Modern Healthspan · 1 reply Daniel Evans Daniel Evans 1 year ago I can't understand her. Is HA good or not? 4 Reply Classic Strategist Classic Strategist 1 year ago Higher levels of Hyaluronic acid are connected to an increased cancer risk. I would disadvise anybody to take it.. Please anybody elaborate? 4 Reply 3 replies 1337jusTi 1337jusTi 1 year ago Jesus Christ, does the intro and outro really have to be +500% in volume? There are other people in my building. 5 Modern Healthspan Reply Modern Healthspan · 1 reply Hyaluronic Acid Fights Skin Aging Fundraiser Dr Brad Stanfield 156K subscribers Join Subscribe 2.6K Share 45,888 views Sep 26, 2021 #SkinCare #Aging #HyaluronicAcid After reviewing the Hyaluronic Acid research from human clinical trials, I've used hyaluronic acid 200mg daily. This video explains the latest trial data, and how hyaluronic acid works. Hyaluronic Acid from DoNotAge: https://bit.ly/2XaNd1y 10% Discount Code: CheckWithYourDrFirst 💊 My full supplement stack: https://drstanfield.com/my-supplements 💊 Supplements I source from Amazon: http://amzn.to/3o2ULOV Thanks for watching, I hope you enjoyed the content and found it genuinely useful. Please consider supporting the channel: ✔️ PayPal: brad@drstanfield.com ✔️ Patreon: https://www.patreon.com/bradstanfieldmd 👕 Merch: https://brad-stanfield-md.creator-spr... ✨15% Discount Code: BRAD ✨ • ProHealth: https://www.prohealth.com/collections... ✨10% Discount Code: BRAD ✨ • DoNotAge.org: https://donotage.org/products/ • Renue By Science: https://renuebyscience.com/?rfsn=5206... Join me over on Twitter: https://twitter.com/BradStanfieldMD Here are the links to the research papers referenced in the video: https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/23783... If you like this video please smash the thumbs up button, it really helps with the Youtube algorithm :-) #SkinCare #Aging #HyaluronicAcid The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel. Key moments View all 369 Comments rongmaw lin Add a comment... Alan Everett Alan Everett 1 year ago One of the big questions I've had about hyaluronic acid (and a number of other supplements) is the proper dosage. Your charts clearly show older people have much less hyaluronic acid than younger people. This reduction is true for a number of other molecules in our bodies as we age. You state that older people only have a quarter of the hyaluronic acid when you're above age 60 as you had when you were much younger. The charts also indicate as you go above 60 the levels go even lower. Since I'm 72 it would seem that I would need a significantly higher dosage of hyaluronic acid than a person who is in their 30s. Ideally we would have some sort of test so that we could use to establish how much more to take but I still am going to guesstimate and take more than you are taking. We are in new territory here but in other areas studies have established normal ranges for various molecules in our body I am making this judgment to increase my dosage based on the idea that there does not appear to be a lethal dosage (LD) that anyone has found using exceedingly high doses of hyaluronic acid or collagen. This lack of a LD is not true for some of the other supplements so caution is advised when trying to go up to higher dosage for other supplements for older people. We (my wife and I) are beginning to try and objectively measure what is happening to our skin. We just began taking pictures every Sunday and storing them so that we can look and see if improvements have happened over time. I am excited to see what other molecules you are going to talk about that will be helping the skin. You previously have discussed collagen well over a year ago but back to our story. About 5 months ago, my wife (age 74) and I (age 72), begin taking both supplemental hyaluronic acid and collagen (Doctor's Best Hylauronic acid supplemented by various types of additional collagen supplements we got off the sale rack at our Pharmacy or big-box store). It took months before we noticed an improvement as we are using the dosages that you have mentioned, that we now believe are to low for older people. We believe that these lower dosages are set for younger people. ie we believe we were underdosing ourselves. There is no question at all in my wife's instance that her skin has drastically improved. We intend to double our dosage next time we order refills for our hyaluronic acid supplements to see if we will get even greater Improvement based on the rationale I've set up set out above. Prior to beginning this hyaluronic acid and collagen supplementation my wife's hands and feet were so dry and cracked that sometimes the cracks went deep enough into her skin that they began bleeding. She has had numerous consultations with dermatologists and there was some improvement but the condition has persisted for over 20 years. The slight Improvement from the dermatologist was nothing like what has happened over the last month-and-a-half. All the dry cracked skin is gone and her hands feel like they did back when she was in her twenties. This all occurred while she was working at her nursing job and having to wash her hands multiple times a day. She had given up any hope that her skin would improve. She is now excited about our supplement stack. We also believe we're noticing improvements in the back of our hands which have thinned out skin on them. What lead us to begin photographing our skin is that we believe some of the age spots are getting fainter and going away and hydration is returning to these thinned areas of our skin. The jury is still out on the age spots and thickening of the skin but hopefully the photographs and chart notations and increased dosages will tell the tale in the next few months. We are also taking other supplements like nicotinamide riboside (NR) so we can't say 100% sure that it's just the hyaluronic acid and collagen supplementation doing this for our skin. Whatever it is, our skin appears to be getting younger or possibly we can just say it is improving greatly. (Also both of our hair is returning to its normal color which we believe is related to the NR supplementation. While hair grows out of the skin we believe the hair color change due to our NR supplementation because other people are reporting hair color changes. These hair color changes have been reported by people who are solely taking NR or NMN.) Hylauronic acid and collegen are also involved in cartilage formation in joints like our knees. After about five and a half months of taking hyaluronic acid and collagen we believe we've noticed an improvement in our knees but we haven't figured out an easy way for Lay people to measure it or to chart it to determine this for sure. In mouse experiments involving other supplemental drugs, they have proved improvements in knee joints by taking X-rays and actually measuring the thickness of the cartilage. We have approached my orthopedic surgeon to try something like this but he thinks we're nuts. He is been replacing people's knees for well over 30 years and didn't want to hear anything we had to say though he was very kind and polite and took some of the studies that we brought with us. We are very convinced that we should take higher dosages than younger people. As stated previously we have planned to up the dosage. Your previous presentations over a year ago are what convinced us to give this a try. Thank you so much and keep up the good work. I hope others will join us in trying to photograph and chart observations about our skin and joints so we can objectively prove these changes. I would love to hear what you think about our dosage hypothesis though I realize you can't be too specific as it would be considered a recommendation. Maybe some laboratory person somewhere will read this and begin the tedious process of measuring hyaluronic acid levels in younger people so we could establish a target range for our supplementation. Again keep up the good work.... Alan Everett, BS, JD citizen scientist, Seymour, TN 94 Reply 15 replies Levi Hancock Levi Hancock 1 year ago I can't believe this guy is 103-years-old. Looking good bruh. 46 Reply 2 replies Merrie Yates Merrie Yates 1 year ago Great 1st episode of your skin aging series. I'm looking forward to more. I have always had good skin with minimal wrinkles (even at age 60) but skin elasticity is increasing becoming an issue. After viewing this video, I plan to give oral hyaluronic acid a try. 8 Reply Mick Miah Mick Miah 1 year ago Hi Brad, A few years ago, aged 53yrs, I decided to cut down my weight as I had fallen into something of a sedentary life-style. I was left with that old problem of excessive and old looking belly skin which no matter how much I exercised never seemed to reduce. Having some awareness of skin structure I began taking Hyaluronic Acid 200mg daily. A year or so later my gut skin looks tighter, less wrinkled and a whole lot more youthful not perfect but very much improved. I understand that this is merely a tale and provides no proof but I think that the improvement in my gut skin is attributable to HA. I really look forward to hearing the conclusions of this series. Keep up the good work- Nice logo:) 33 Dr Brad Stanfield Reply Dr Brad Stanfield · 9 replies Lúcia Ametista Lúcia Ametista 1 year ago Hi Brad, thank you for this video. I would also like you to expand on HA's role with collagen production, and whether taking collagen supplements will enhance HA further, or vice versa. I also don't think there's an overlap with companies producing serums, as it would still be beneficial to take both oral supplements and continue using skin serums. Thanks again. 12 Reply Anthony Parkinson Anthony Parkinson 1 year ago (edited) I am so glad you are doing this series. Currently, I apply SPF every day and use tretinoin a few times a week. These are topicals that are proven to keep skin healthy and looking younger for longer, however I am intrigued to know what supplements I can take for my skin. 8 Dr Brad Stanfield Reply 3 replies Maärten Maärten 1 year ago I'm very happy that you are doing this series. I have attended to my skin since I was a child and it has paid off for me at 61 years with almost no wrinkles or sagging. I take HA but I am using Jarrow and I'm not sure that it's high molecular weight HA. I also take marine collagen and eat a healthy diet with lots of vegetables. Topically, I also use HA and exfoliate with lactic acid. I used copper peptides some years ago but was never sure if it did anything. It's something worth exploring and perhaps you can do an episode on copper peptides. Daily sunscreen is essential. 17 Reply 7 replies carbonpictures carbonpictures 2 months ago I'm 59 and finally decided to help repair my sun damaged skin. I am micro-needling and using hyaluronic acid. I'm going to do a before/ after video when I get the final results. Reply Marco G Marco G 1 year ago Thanks for another great video Brad. It would be great to learn how you monitor your self, especially considering all the supplements you take, blood tests, urine, etc. how often and what you look at to make sure the supplements or the mix of them are not causing issues in your body. 1 Reply Keith H Keith H 1 year ago Glad you are doing this series. I ordered Hyaluronic Acid today. I look forward to more information on skin care as we age. I also reviewed your supplement stack. How would this be different if you were in your 60's. Would you start taking NMN? I would be interested in seeing a video on this topic. I'm sure many older people follow you. 2 Reply Charlie Parker Charlie Parker 1 year ago I had no idea that oral hyaluronic acid had anti-wrinkle effects. It will for sure be interesting to see more data on that. I would think the skincare industry would already be onto that, since topical HA is a darling and in so many products. My daily skincare stack: Oral vitamin A Topical: Azelaic acid Vitamin C SPF 50 Niacinamide Tretinoin 19 Dr Brad Stanfield Reply Dr Brad Stanfield · 11 replies one time one time 1 year ago This was interesting. I have supplemented with hyaluronic acid for 18 months now. It is hard to quantify any benefits since my diet is good, I take other supplements, use red light and exercise etc. In my opinion keeping skin looking young and vibrant is not vanity alone....almost every disease, illness is reflected in the skin. A person who looks "well" with good skin - is probably healthy. So i will continue taking hyaluronic acid and hope for the best. Thank you for all your work and your generosity in sharing it. 7 Reply Louis Tulloch Louis Tulloch 1 year ago DR. Brad - you are amazing! I love the easy way you deep dive and take us with you. I have a love for alternative modes of healing/medicine so I'm always finicky about the medical side of things. You seem to be a "tough customer", so to speak and it's a joy for me to see you pull apart the various and relevant subjects in your videos. I want to thank you for that. Dr Brad Stanfield Reply Sean Ryan Sean Ryan 1 year ago Hello Brad. Do you recommend taking 200mg of hyaluronic acid in one dose or spreading the dose over the day? Thanks in advance and thanks for your videos :) Reply Dave King Dave King 1 year ago Hi Brad, I see that HA can help skin. I however see a number of research papers on HA with regards to Atherosclerosis and it's elevated levels where Arterial lesions are found. Have you read these studies and do you see a risk to arterial health? 5 Reply MBA CHIROPRACTIC LIFESTYLE CHANNEL MBA CHIROPRACTIC LIFESTYLE CHANNEL 1 year ago Thank you for sharing Brad. I haven't tried oral HA supplements, but have tried HA lotions which are not that pricey (Hada Labo etc). I tried a lotion which contains HA molecules of different sizes (low molecular weight appear to be able to penetrate to the deeper skin layers). It did improve skin moisture, but is not magic. 4 Reply Stuart Malin Stuart Malin 1 year ago Thank you for your well-researched and professionally presented assessments. I have been taking Hyaluronic Acid for a long while. I hugely resonate with your statement early on to the effect of - Keep Sugar Intake Low!! - that is the most important first step. 3 Reply Brett Anhorn Brett Anhorn 1 year ago Great videos! I've been following you for a while now and have been using NR and Vitmain D for quite some time. I've also taken Universal Animal Flex for years, to help with sports injuries. As I've been looking more into longevity, a number of the ingredients seem to jive as well as longevity supps, including Hyaluronic Acid. Is there anything in it (besides cost! LOL), that you would recommend against taking daily? I take it a few times a week currently, not daily. It does contain a number of interesting ingredients, namely Quercetin, ginger, tumeric, zinc and lots of vitmain C as well. 1 Reply Yair Chertkow Yair Chertkow 8 months ago (edited) Hi Brad, you mentioned the importance of taking a high molecular weight hyaluronic acid supplement. Can you explain (or make a video) about the differences and benefits of low vs high molecular weight hyaluronic acid when taking it oraly? Why is it important to take high molecular weight hyaluronic acid? Moreover, how can I tell if the supplement has low or high molecular weight? Almost all supplements don't mention this. Some supplements just say sodium hyalurenat. Thanks Reply 1 reply Talia Talia 1 year ago (edited) Thanks for another great succinct video with various interesting details. I use a supplement with both collagen 1, 2, 3 and hyluronic acid + Vit C for absorption - all-in-one, to help with all facets: skin/joints/hair/nails/ligaments etc though it probably isn't necessary till one gets a bit older 2 Reply empalio empalio 1 year ago Incidentally, yesterday I decided to order both collagen and Hyaluronic Acid to see if it helps joint recovery after exercise. I'll keep an eye on the skin care aspect. Reply Lewis Bong Lewis Bong 1 year ago Dr Brad , what’s your results after taking the product! I’m 61 healthy individual and please give me your personal comments and how long did you start noticing the benefits? Thank you 🙏 Reply Andrew Taylor Andrew Taylor 1 year ago (edited) I took 100 mg Hyaluronic Acid daily. After a few weeks, I got vertigo. I think because my body absorbed water and my inner ear structures became swollen. A year later, I tried 100 mg every two days, so effectively half of the dose. The same thing happened. My conclusion is that Hyaluronic Acid definitely will increase your body's moisture levels; unfortunately in my case it has side effects. 28 Reply 6 replies Mark Trail Mark Trail 1 year ago Would love a video on how exercise promotes skin health. Thx for all your hard work, Brad. 5 Dr Brad Stanfield Reply Dr Brad Stanfield · 2 replies Brazillionnaire Bob Brazillionnaire Bob 1 year ago Great video… keep them coming doc! Can you also do a video covering the top 5 supplement/vitamin stack covering age groups 30, 40, 50 and 60 men/women? Reply Kelly Farley Kelly Farley 9 months ago Dr. Brad Stanfield, you should consider adding to your Skin Care series how polyphonies interact with the skin and if there are supplements to suggest. Reply Angela Morris Angela Morris 7 months ago (edited) I took hyaluronic acid about 7 years ago, and I started breaking out with acne on my back. I stopped taking it, then the acne went away. I had an experience where I broke-out with crater-type bumps - all over my back, at 10 years old. It was extremely devastating. The dermatologist prescribed me Tetracycline, but it hardly phased them. Well, I loved being outside - So, I decided to start sun-bathing. To my surprise, the acne started to clear-up. I just started back on hyaluronic acid yesterday. I want to see if I will get the acne, again. If I do, I'll just take vitamin k2/D3 supplements, and get out in the sun between 3:00 - 4:00 pm, as this is the best time to not be as exposed to UV rays that are damaging. Also, I'm doing partial Keto and Fasting (due to my Thyroid issues). Do you know what causes the acne breakouts? Thank you. Reply pelawren pelawren 1 year ago Thank You Dr. Brad for pointing out the importance of choosing one with high molecular weight. QUESTION: Will taking 2 capsules of 100 mg each qualify as high molecular weight? 3 Reply Peter Peter 1 year ago (edited) Dr. Brad I've started looking at inhibitors of HA and found hyaluronidase which is an enzyme which breaksdown hyaluronic acid. Appears some berry extracts may inhibit hyaluronidase to some degree, and thereby preserve HA, but need to look much further in PubMed. So made me wonder if loss of HA is only due to buildup on hyaluronidase (assuming it increases with age) or if there is loss of HA production, or both 12 Reply 3 replies l gee l gee 1 month ago Just received the hyaluronic acid and collagen peptides from DNA using your code. Can’t wait to try it. Taking the HA with saw palmetto, pumpkin seed oil, and amino complex to see if it helps my thinning hair. Reply 1 reply Sophia Sophia 1 year ago Thanks for the video. What are your thoughts on astaxanthin as antioxidant and longevity supplement? 7 Reply Mauricio Oliveira Mauricio Oliveira 1 year ago Hi Brad what would you consider a low sugar diet? How many grams of carbs per kg? I've been following your advice on reducing animal protein but the carbs go up substantially if I'm getting most of the protein from lentils and similar low methionine protein sources. Reply 1 reply Simon Simon 1 year ago I've applied liquid topical Hyaluronic Acid to my face once per day for years and it works really great. 1 Reply R. Guerreiro R. Guerreiro 1 year ago Hello Brad Will you talk about glucosepane? I'm kind of scared about this evil molecule I'm even trying to separate fructose sources from proteic foods in different meals in an attempt to reduce the chance of it's formation Reply Malin Skytt Malin Skytt 1 year ago Awesome video! For me, as a 44 year old woman information like this is pure gold. However another “big” problem is that the bones in the face gets smaller when you age so my skin sags anyway. I’ll guess it’s nothing you can do about that? 🤷🏼‍♀️ 2 Reply 12 replies Mayank Jairaj Mayank Jairaj 9 months ago Is there any correlation between hyaluronic acid and hair thinning? Reply chuck becker chuck becker 1 year ago Very thorough and independent review. Brad's brilliance instills confidence in me. 3 Dr Brad Stanfield Reply 2 replies Anthony Castro Anthony Castro 1 year ago Really interested in supplementing with hyaluronic acid, But I'm really worried of the increase likelihood of developing kidney stones while on it. Anyone know how to counteract it? Reply BlackMartini BlackMartini 1 year ago Can you make videos on what to avoid? Example: poly unsaturated fats oxidate into aldehydes that damage mitochondria. 2 Reply Falcon77 Falcon77 1 year ago I’ve also read that skin aging is reduced using HA along with BCAA and Saw Palmetto 4 Reply Jack Mackay Jack Mackay 1 year ago Hello Brad, thank you for the video. Could you answer a question for me please? All of the studies you referenced were sponsored by Kewpie as you detailed and they all used low molecular weight HA however at the end of your presentation when you recommended DONOTAGE you say you take high molecular HA and DONOTAGE agree with you and actually warn against low molecular weight HA saying it can cause inflammation. Yet the only studies for the efficacy of HA are the Kewpie studies which all used low molecular HA! Could you elaborate on this seeming discrepancy? 26 Reply 6 replies King Ramze King Ramze 1 year ago HA creams are excellent for dry skin as it's a humectant, and HA makes up a large portion of our extracellular matrix, so if studies show it can be absorbed and used, I don't see any reason not to supplement with it as well. I'm taking it - largely as a preventative against joint issues in the future. Reply Mélo World Mélo World 1 year ago Hello, What do you think of low molecular weight hyaluronic acid supplements that could be inflammatory? Thank you. 1 Reply Ian Goddard Ian Goddard 1 year ago Preservation of skin integrity needs to be a huge part of any health-extension plan, but it is widely overlooked, seen more as a matter of cosmetic vanity than the core health issue it actually is. Having cared for several elderly family and friends, I observed that skin thinning increases the risks of skin cracking, bleeding and even tearing off. A friend in her 90s feel in a parking lot and her rice-paper thin skin (not an exaggeration) peeled off across her upper arm and muscles feel out. It was a painful disaster requiring surgery to put back. I helped to treat her wound thereafter. As I near 60, I've been watching my skin start to thin too. I need to use gloves when working in the yard and with heavy tools more because my skin is thinner and more prone to cracking and abrasions than when I was younger. However, I'm literally watching what had been increasingly shiny and crinkly skin on the back of my hands, which I see all day, reverse and now becoming noticably smoother and softer after several months of oral hyaluronic acid. It look several months to see a difference, for a while I thought nothing was happening. I'm right at the stage where elderly skin thinning has been emerging, so I'm seeing this and able to detect a difference. Hopefully I can meaningfully push back with HA! And indeed I'm seeing signs of hope! 2 Reply 2 replies Kevin Martin Kevin Martin 1 year ago (edited) There is some concerns that glycosaminoglycans such as glucosamine can cause an increase in intra ocular pressure. As hyaluronic acid belongs to the glycosaminoglycans, is there some concerns about it too regarding eye health? 1 Reply Paola Cherchi Paola Cherchi 1 year ago Hi Brad, I would like to start taking hyaluronic acid, in your opinion is it better to take it sublingually or to swallow the capsule? Thanks Reply Niall STALLARD Niall STALLARD 1 year ago Hair, nails and skin aren’t just vanity, they are also outward markers of our inner health. Looking good ideally should be coming from my underlying health being good. For me trying to be 100 percent perfect on anything is discouraging, stressful and unrealistic. For me, my goal posts are set between good enough/excellence. I call that my 70/80/90 bars and of course if I’m regularly hitting 90, the bars are raised. Of course when all of us here are 150, we don’t want to look a day over 30. Reply Mélo World Mélo World 1 year ago That's a bit of additional knowledge. Supplement in kappa elastin (from vivaline French laboratory) and a product that I have NEVER heard of despite ALL MY RESEARCH on beneficial supplements it is ROSMARINIC ACID that has a glycating effect (eliminates glication) patent of a French laboratory and also ceramides as a food supplement. I guess my country 😁 Reply jesperramadan jesperramadan 4 months ago What are the effects of Hyaluronic Acid on arteries? Reply The Water Dragon The Water Dragon 1 year ago But is it really skin aging or just appearance? I imagine if you slow or reverse aging generally then the skin would follow. Still a great series and having had a few BBC's and on SQC I'm thinking cancer prevention might be something worth floowing up but since its just cosmetic maybe they don't bother. Reply abc abc abc abc 1 year ago (edited) I prepare my serum with N-Acetyl Glucosamine upto concentrations of 5%, because, this would naturally help building Hyaluronic Acid in the skin. I generally opt for pro foods, or co-factors which help in building the specifics that I'm interested in! Exactly, what I do with Collagen, instead of using it topically, I use amino acids Glycine, Hydroxyproline, Analine, Proline and Arginine both in my serums and obviously, in my diet. Because, in my body it would develop all over. Not forgetting having plenty of bioflavonoids and natural Vitamin C with artificial Ascorbic Acid. I add a lot of Ayurvedic herbs in my face maks like Indian Kino, Andrographis Paniculata, Amla and obviously, a few others which have scientific literature to back it up. Same goes for Glutathione, I go in for NAC, Selenium, Sulphur, Manganese which add for certain compounds that make for it because , obviously, Oral supplementation of Glutathione doesn't work. Same goes for Mitochondrial support by adding Alpha Lipoic Acid, Riboflavin, CoQ-10, Nicotinic Acid Thiamin, Vit. C and K, Creatine, Carnitine. Also, Remember no matter what You do to the skin, It will shed. So, on top of the topical solutions, add nutrients to your diet which will help even more on the cellular level. Obviously, stay away from many claims of this and that, they have Additives that are not actually needed. I'm 31, I look probably 24-25 is what I often get told. That is because, I took my health very seriously, probiotics, prebiotics, A, B, C, ...X, Y, Z. We get only one live to live. Life it beautifully (also, remember, what Suits me, doesnt have to be that has to suit everyone, always be ready for permutations) 2 Reply olasaltasm olasaltasm 1 year ago Vitamin C+ Hyaluronic Acid, What do you think about supplements that combine these two? Reply The Ancients Ancients The Ancients Ancients 1 year ago (edited) Hyaluronic acid plus Liposomal Vitamin C plus Liposomal glutathione plus astaxanthin, fish oil, niacin, marine collagen do great things for the skin 7 Reply 1 reply Classic Strategist Classic Strategist 1 year ago Hi Brad, what do you think of the potential increase cancer risk while supplementing with Hyaluronic acid? 28 Reply 5 replies Jeremy Jeremy 1 year ago Do the trials you mentioned use high molecular weight HA? 8 Reply Ndaily Ndaily 1 year ago For the part that is not absorbed , how is it broken down and exit the body? Does it put extra pressure on kidneys? Does it take anything to be disposed? (For example extra nmn needs methyl to be metabolized thus depriving body of that, is there any sort of similar thing going on here? Thanks so much for for great work Brad! 1 Reply 2 replies Orders Shentu Orders Shentu 5 months ago The human clinical trials refered in this episode were actually using LMW-HA. It is not clear to me that taking the HMW-HA from donotage will have the same benefits on skin and joints as LMW-HA. Reply Faizal Rahim Faizal Rahim 1 year ago What about the risk of accelerating proliferation of existing cancer cell ? I don’t have cancer, yet, but I do have a history of cancer in my family. Im just afraid if I already have existing cancer cell and hyaluronic acid will just accelrate the progress. 14 Reply 2 replies Javon Bangs Javon Bangs 1 year ago (edited) Will you be touching on other skin modalities and not just "skin supplements"? For example: tretinoin, sunscreen, vitamin C (topical), exfoliation, etc. 3 Dr Brad Stanfield Reply Dr Brad Stanfield · 3 replies Kim Davis Kim Davis 1 year ago Yes Brad I do take HA orally & I’m pleased with the results 2 Reply Bevan Bevan 1 year ago What's a good budget hyaluronic acid supplement alternative? 2 Reply hotyute hotyute 1 year ago Amazing work. Have these clinical trials only recently concluded? Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Yami Yami 10 months ago Dr. Bradfield, I am curious about the hyaluronic acid content of egg whites. A lot of sites say they have it - not just the shells, which have over 20mg each. I could not find any study determining the HA content of the whites specifically. If it is even a fifth of the content in the shell or membrane, we're talking over 200mg per egg. Thank you Reply 2 replies Brian Withers Brian Withers 1 year ago I'm not so interested in the skin benefits. What is the proposed mechanism to extend longevity? Reply Dr. Angela 新希望健康 Dr. Angela 新希望健康 1 year ago What do you think about oral HA and some cancer link? 9 Reply Roy Zlatan Estevez Roy Zlatan Estevez 1 year ago It's so bothersome how many things break down with age and how many things need to be tinkered with and fine-tuned. I'm starting to think it's rather not worth the effort, just park the body and let it rot for a few decades and wait for a actual rejuvenation somewhere down the line in the next 40-60 years (which I think I still have). But it's a risky gamble, I'm not quite willing to take it yet. And not everyone has enough time left to wait for actual treatments of course. 1 Reply Gem Gem 1 year ago (edited) What about the cancer issue??? When will you address it?? Also why high molecular weight?!? Isn't low molecular HA absorbed better???? 4 Reply Jack Mackay Jack Mackay 1 year ago (edited) All of the studies you referenced were sponsored by Kewpie as you mentioned and they all used low molecular weight HA however at the end when you recommended DONOTAGE you say you take high molecular HA and DONOTAGE agree with you and actually warn against low molecular weight HA, saying it can cause inflammation, yet the only studies for the efficacy of HA are the Kewpie studies which all used low molecular HA! Could you elaborate on this seeming discrepancy? 65 Reply 7 replies Nancy Salvaggio Nancy Salvaggio 1 year ago I use bulk supplements powder. Mixed with my vitamin C powder in lemon water in the morning. 3 Reply John Eli John Eli 1 year ago Useful video as usual. This is one of the few channels that I allow notifications from Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Katerina Longoria Katerina Longoria 9 months ago I feel like HA is gonna pull moisture from deeper layers of the skin, pull it to the surface of the skin and make it easier for your moisture to evaporate into the environment. Reply Balasubramaniam Kajanan Balasubramaniam Kajanan 1 year ago Hi doctor, Please put a full research video about sulferophane supplements Reply David MM David MM 1 year ago That was a good video. Congratulations for the work done! 4 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Too Future Too Future 1 year ago Do you have any thoughts on OneSkin and their peptide solution? Reply Rustam Bartov Rustam Bartov 10 months ago can it help with loose skin? Reply Things To Know By Timothy P Things To Know By Timothy P 1 year ago I would like it to help regenerate the connective in my joints. So, I will start supplementing extra hyaluronic acid in addition to the the chicken 🐔 bone 🦴 broth. Reply Pakistanicecream Pakistanicecream 1 year ago This is a beautiful video, I could barely hold my tears back. Keep up the great work, Brad - $PRCY 1 Reply 1 reply Paul Johansson Paul Johansson 1 year ago Thanks for a good walkthrough. 1 Reply j simon j simon 1 year ago I would take with organic vitamin c,killing,vitamin d ,antaxthin, and beet roots caps. Reply Lotze N Lotze N 1 year ago Thank you for the Info. How high is the kDa from the donotage Produkt? Thank you 1 Reply Gene Smolko Gene Smolko 1 year ago I've been taking 100 mg twice a day, I wonder if that's better than 200 mg once a day. 1 Reply Sirt1 Sirt1 1 year ago When and how to take it for best absorption? I usually fast in the mornings, and open my fast with collagen protein and lime water 1 Reply shoes121255 shoes121255 1 year ago Are there any other quality brands of high molecular weight HA out there? $45 a bottle from do not age seems steep. 1 Reply Anne Booyse Anne Booyse 1 year ago Thank you Dr. Stanfield. Reply Bitchute is better than Youtube Bitchute is better than Youtube 1 year ago Just guessing but if you have bacteria in your gut that eats , and you feed that bacteria, you will get more of them over time, meaning it will become less efficient over time 1 Reply Wajeeh ElWajeeh Wajeeh ElWajeeh 1 year ago Waiting for the next episode😍 4 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Pramuan Chutham Pramuan Chutham 1 year ago Isn't Branched Chain Amino Acid which ties the long peptide chains together equally important, especially comprising 35% of the muscles. Reply Dimitrios Pavlis Dimitrios Pavlis 1 year ago Thanks, when to take the supplement before food or after in daytime or in the morning? 1 Reply TiMalice2009 TiMalice2009 1 year ago (edited) I heard years ago on a podcast that HA is great to wrinkle proof skin. Don’t know if I have to buy this $$$$ one though. Reply vonwolly2 vonwolly2 1 year ago Well would really like some advice hyaluronic acid there's a lot of articles that claim that it causes cancer. My father has really bad knees he's 83 years old and hyaluronic acid really helps bad knees. But I'm scared to give it to him because I don't want to cause cancer. Are these legitimate studies is there any truth to this 16 Reply 1 reply Gerry R Gerry R 1 year ago Metformin affects AMPK which quells free radicals which is good for the skin. A friend used metformin long term and his skin was exceptional. Metformin can be used topically. 13 Reply 9 replies Juan Carlos Juan Carlos 1 year ago Will you do a tretinoin and sunscreen video? 1 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Kevin Walsh Kevin Walsh 1 year ago What is considered high molecular weight in this context, in daltons? 5 Reply 1 reply chen cohen chen cohen 1 year ago How could i find good quality hyaluronic acid brands that doesn't cost that much? Anyone knows which brands are best quality? Or where should i check? 1 Reply Joshua Alvarado Joshua Alvarado 1 year ago Oof doctor, you got me excited for the data but wow that price point is out of my budget. Any other suggestions for a med student😩 3 Reply 1 reply Kelly Brown Kelly Brown 1 year ago Brad, you look amazingly lifelike 1 Reply Chris Connor Chris Connor 1 year ago Do you know how much Hyaluronic Acid is in collagen? Reply Joseph J Roy Joseph J Roy 1 year ago What is DoNotAge's source of their hyaluronic acid product? 3 Reply 2 replies Shannon Reis Shannon Reis 1 year ago This is cool, but why not rub it on the skin? And, if we did, could we use more cost-effective versions? Reply 1825vine 1825vine 4 months ago can I put the powder directly in the mouth or I have to mix them with water? Reply LQ LQ 1 year ago You MUST review dmae! 2 Reply Gregory Carrier Gregory Carrier 1 year ago (edited) There was a study showing reduced systemic inflammation after skin cream with hyaluronic acid, cholesterol, and ?. 1 Reply IblisTheMage IblisTheMage 1 year ago Considering upping my daily dose to 400 or 600. Have been taking HA for a year, around 200. Considering doing some incremental dosing experimentation, trying out 400 for a month, then 600, or beyond… I am not particularily concerned about wrinkles, it is mostly to experiment… Any thoughts? 3 Reply 2 replies Gaius Gracchus Gaius Gracchus 3 months ago It is a puzzle as to why hyaluronic acid does not get trashed in the stomach acid and GI tract. Reply Kevin Cramer Kevin Cramer 1 year ago Isn't HA implicated in cancer spread? 3 Reply BakamonNO BakamonNO 1 year ago exiting news. Thank you for sharing Reply janet lesley janet lesley 1 year ago Awesome. Thank you. Reply Teo K Teo K 1 month ago Why high molecular and not a mix of low, medium and high MW Hyaluronic acid? Also why not a liposomal formulation? Reply WanderingDoc WanderingDoc 1 year ago Is it advisable to put a hyaluronic acid serum on your face or just take it orally? 1 Dr Brad Stanfield Reply Dr Brad Stanfield · 3 replies MrFlyingSheep MrFlyingSheep 1 year ago So what supplements to use to thje end of life? D3, Magnesium, Resveratrol, NMN?+++ 1 Reply Cool Dude is cool Cool Dude is cool 1 year ago Bodybuilders use this as an injectable for muscle site enhancement. Would that also have a health benefit? 1 Reply 2 replies d w d w 1 year ago What about liposomal hyaluronic acid Reply Chad Howarth Chad Howarth 1 year ago The benefits to skin quality of supplemental hyaluronic acid are unmistakable. At 200mg per day, it took 2 weeks before I could notice a difference. Trouble is, it causes the skin to retain more water than is necessary. I ended up getting rashes and had to stop. Some of the rash became infected with staph, and left scars on my legs. I'd do it again, but at 100mg on a 5 day on, 2 day off cycle. I think it's important to proceed carefully until you know more about how you'll respond to it. 3 Reply 14 replies Matthew Matthew 1 year ago (edited) "We speculate that naked mole rats have evolved a higher concentration of HA in the skin to provide skin elasticity needed for life in underground tunnels. This trait may have then been co-opted to provide cancer resistance and longevity to this species." Doesn't really sound like a benefit that would be conserved across species, unfortunately. Reply Sandy Demian Sandy Demian 2 months ago Is it true they can contribute to gallstones Reply RJM 527 RJM 527 1 year ago I asked Now Foods about their Hyaluronic Acid. "Our HA is 1 million Daltons which is considered high MW. This avoids issues with impurities and varying molecular sizes that can be associated with animal sourcing of this compound. Our source material is microbial fermentation so is vegan. This molecular size is safe and ideal as it balances well absorption/degradation. A molecular size that is too large may not absorb well and too small may function differently than it should" NOW Product Information Dept Reply 1 reply Ed Ed 1 year ago When you take it whit 10gr Collagen powder type 1,3 you have a perfect stack Reply Michael Bradley Michael Bradley 1 year ago Really! for fantastic perfect skin all you need to do is eat healthy (vegan) and supplement 1000mg of vitamin C a day. All vegans who maintain a good diet always look remarkably younger for their age, proven less wrinkles. Gee I wonder why that is? 1 Reply 16 replies Thank YOU Thank YOU 1 year ago It won't apply the 10% discount code...??? Reply Assaf Saadon Assaf Saadon 1 year ago HELLO DOCTOR. GREAT CHANNEL. PLZ WE ALL BE APPRECIATED IF YOU CAN SAY SOMETHING ON SOME RESEARCH SAYS HA CAN PROMOTE CANCER CELLS. LOTS OF COMMENTS HERE ON THIS ISSUE AND WE ALL WANT TO KNOW WHAT YOUR THOUGHT ABOUT IT. THANK YOU VERY MUCH. 2 Reply 0dq0 0dq0 1 year ago And again the connection between HA and cancer was not examined. This video is repeating the old one which brings me to conclusion that the author tries to push referrals. 3 Reply Hatem Zayed Hatem Zayed 10 months ago (edited) Does hyaluronic acid supplements have a correlation with cancer ??? Reply pi3ni0 pi3ni0 2 weeks ago Why high-molecular? Reply Matthew Matthew 1 year ago Yikes! "Pancreatic cancer cells shown to feed on hyaluronic acid". Youtube won't let me link it, but you can google it. I'm thinking more & more.. the best way to live longer is 1. exercise. 2 eat well. 3 sleep well. 4. low stress. 5 friends & family. And hope that science figures out actual anti aging science. 2 Reply Manfred Druschowitz Manfred Druschowitz 1 year ago I'm 72 and don't have any wrinkles. 2 Reply 1 reply toom2141 toom2141 1 year ago great video thanks Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply Barbara Lachance Barbara Lachance 1 year ago I have heard 2 real dermatologists say that using hyaluronique acid in skin care is a marketing scheme. 🤦🤦 1 Reply 2 replies Ginnie Beany Ginnie Beany 1 year ago (edited) Well , you do have beautiful skin . Reply I-heart-Google I-heart-Google 1 year ago 5:54 "I also make sure, to take high molecular weight HA." ...now what do you mean by the 'high molecular weight'? Is it 500-700? Or is it 1000 - 2000? Or even more? 1 Reply Phillip Evans Phillip Evans 1 year ago Patients with T2D should not take this Reply James Brown James Brown 1 year ago What is radio labeled ? Reply BlackMartini BlackMartini 1 year ago Do not age mentions anticancer properties for HA. How so? 1 Reply Riordan Pett Riordan Pett 1 year ago Sounded like you were confusing collagen with hyaluronic acid with those 'won't be as strong' and 'structure' descriptions and terms... 1 Reply SP95 SP95 1 year ago The naked mole rat is our future 😅 1 Reply Mehmet Çirkin Mehmet Çirkin 1 year ago (edited) How can we know a supplement company is safe ? A lot of company is selling rice flour in capsules instead of real ingredients 1 Reply 2 replies spectoral spectoral 11 months ago You don't have any wrinkles to suppress?! Reply Keith Haken Keith Haken 1 year ago ✌️🙏🤛👌 Reply Viamem Viamem 1 year ago Biotin, Pls. 1 Reply Jeff C Jeff C 1 year ago Why can't a disinterested non-biased medical research study be done? 1 Dr Brad Stanfield Reply Dr Brad Stanfield · 2 replies Levi Hancock Levi Hancock 1 year ago How do I grow my thing? You know what I mean. 1 Reply darkpatches darkpatches 1 year ago I feel like you haven't addressed why you use "high molecular weight" hyaluronic acid. I watched your other vid on it a few weeks ago for that reason. Have I missed it somewhere? If not, why do you make a point of using it? 7 Reply 10 replies Niko Vanegas Niko Vanegas 1 year ago First comment yay. Love your content 3 Dr Brad Stanfield Reply Dr Brad Stanfield · 1 reply GalacticWoman GalacticWoman 1 year ago There is little point for you to supplement it at this young age. 4 Dr Brad Stanfield Reply Dr Brad Stanfield · 2 replies Christopher Ellis Christopher Ellis 1 year ago (edited) Gerovital! & 100mg orally per diem 2 Reply listen2meokidoki listen2meokidoki 1 year ago He's flogging it. 1 Reply Catalytic Centaur Catalytic Centaur 1 year ago Hm. Quite something similar, you reported one year ago. Reply John Bielenda John Bielenda 1 year ago Think HA plus good genetics .......... Reply Barre86 Barre86 1 year ago sponsored by a company? no thanks o/ 6 Reply 1 reply George G George G 1 year ago Seems like it is sxtracted from chicken combs in China and marketed as beauty cream snd supplements. . I prefer not to ingest this. Need a non animal source. 1 Reply 1 reply Craig Hocker Craig Hocker 1 year ago This is nothing more than a long advertisement. No real skepticism or meaningful critique here. Rather disappointing. I laughed out loud when said you would be taking HA. At 29 yo, that’s just flat out ridiculous. Someone over 60 maybe, perhaps, though I’m betting what is sufficient dosage is likely not well known. No justification for spending thousands in your 30’s and 40’s on this. The exercise, sleep, and good diet you mentioned at the beginning makes a heck of a lot more sense than adding one more supplement. 2 Reply Free Gardens Free Gardens 1 year ago Did you delete my educated and referenced comment about dangers of taking HA? This is VERY irresponsible! Reply 1 reply Magdalena Magdalena Magdalena Magdalena 1 year ago (edited) I'm sorry to see this, but you just copying here all the informations given already by Dr Dray in her video (published 4 months ago)... you just advertised some product...expected something more.... disappointed 1 Reply shreeya 111 shreeya 111 1 year ago How old are you 1 Reply 5 replies scruffyhenry scruffyhenry 7 months ago overpriced stuff -what a ripoff Reply Jeff Wilken Jeff Wilken 1 year ago Take a shot every time he says “hyaluronic acid.” … Anyone still alive? Reply Omnisniff Omnisniff 1 year ago The latest dose from our favourite ageless psychopath Reply 2 replies thetackroomtx thetackroomtx 1 year ago Just starting the HA after watching this video. Im 61.5 I have just started taking the collagen in the am@ 8g with my lemon water. I wanted to add in the HA but get nervous about overdoing so this weekend I started with 50mg on empty stomach with the collagen. then waited 30-40 min before my next round of supplements. was ok . Monday took 50mg of the HA ( double woods brand) and then 20 min took my L Tyrosine and R ALA which also have to taken on empty stomach - wow had a reaction. Heart racing feeling really weird. Thoughts please, I want to continue the HA but nervous about another reaction with other supplements 1 Reply Levi Hancock Levi Hancock 1 year ago I can't believe this guy is 103-years-old. Looking good bruh. 11 Reply 1 reply Slowing Aging with Sirtuins, NAD and Hyaluronic Acid - Dr Vera Gorbunova Siim Land 132K subscribers Subscribe 448 Share 8.5K views 1 year ago 💯💯Subscribe for videos on becoming superhuman: https://goo.gl/TSDCuv Timestamps: … License Creative Commons Attribution license (reuse allowed) Shop the Siim Land store Stronger by Stress Collection Sticker $6.99 Spring Stay Empowered Dark Sticker $6.99 Spring Stay Empowered Dark Mug $16.99 Spring Stay Empowered Dark iPhone Case $19.99 Spring Stay Empowered Dark Samsung Case $19.99 Spring Stronger by Stress Vitruvian Man Yoga Mat $49.00 Spring 60 Comments rongmaw lin Add a comment... Siim Land Pinned by Siim Land Siim Land 1 year ago Timestamps: 01:10 How Vera Became a Longevity Scientist 05:00 What Causes Aging 08:45 What Speeds Up Aging 10:39 Telomeres and DNA Repair 13:00 Sirtuins and Longevity 16:35 How Sirtuins Work 19:05 Human Research in Sirtuins 26:56 NAD+ and Sirtuins 32:17 How the Body Produces NAD 38:08 Hyaluronic Acid Benefits 44:45 New Compounds for Aging 47:20 Rapamycin and Metformin DoNotAge SIRT6 Activator - Use Code SIIM: https://donotage.org/products/sirt-6-activator-sub/%20 DoNotAge - Use Code SIIM: https://donotage.org/products Video About Things That Slow Aging: https://youtu.be/Vm8ACu4iHvo Video About Things That Speed Up Aging: https://youtu.be/o1ye3G5KHkc Metabolic Autophagy Book: https://amzn.to/2W4YfDF Stronger by Stress Book: https://amzn.to/2VhuXTn The Mineral Fix Book: https://amzn.to/3yhey3y The Immunity Fix Book: https://amzn.to/3mssSQI Metabolic Autophagy Master Class: https://www.siimland.co/metabolic-autophagy-master-class Total Sleep Optimization Video Course: https://www.siimland.co/total-sleep-optimization-video-course Metabolic Autophagy 4 Week Meal Plan: https://www.siimland.co/offers/EwhNysUs Intermittent Fasting Video Course: https://www.siimland.co/offers/JL2Nx9Rw 10 Reply Brook Storm Brook Storm 1 year ago Fantastic interview. What a wonderful scientist and a delightful person Vera is. Her smile is healing. I appreciate how you remain silent to allow the maximum delivery of precious info and speak only to advance the conversation. Fabulous. Thank you 9 Reply Jeff V Jeff V 1 year ago Another great interview, Siim. Thanks much. So many new discoveries in recent years in terms of health and longevity enhancers. I've basically gone "all-in" and take NMN, Resveratrol, metformin and another 6 or 7 supplements, plus exercise nearly everyday, do intermittent fasting, meditation, etc., etc. My guess is I live to 251. 😂 Actually, I realize we're all Guinee pigs at this juncture with precious few conclusive long term studies performed on humans using some of these newer molecules/supplements. But for those over 50, I'm thinking, "Why wait?" The potential downside to these newer supplements appears to be minimal, so I'm not concerned about being a lab rat. 9 Reply 5 replies Charles Runthesum Charles Runthesum 1 year ago Wow, what a wonderful Researcher....smiling often and full of honest information....thank you Dr. Vera.. I'm a new fan of you and your work.... 3 Reply Tee Bone Tee Bone 1 year ago Thanks Siim, I always appreciate your thoughtful approach to this deluge of information, you don't just go off the deep end like a lot of influencers. 1 Reply Manuel Alberto Arevalo Manuel Alberto Arevalo 1 year ago Absolutely Awesome! One of the best interviews in your Chanel. 👍 3 Reply Катя Щербакова • Биохакинг Катя Щербакова • Биохакинг 1 year ago Thank you for inviting Dr Gorbunova! Great interview 1 Reply Luke Claydon Luke Claydon 1 year ago Great vid really interesting 🤔 Layne Norton said that MTor is regulated differently in skeletal muscle compared to organs. Any ideas about this? Reply 1 reply busysuperhuman - Dr Sara Pugh busysuperhuman - Dr Sara Pugh 1 year ago Why would anybody dislike this video ? Very good content thx 2 Reply 1 reply InSync3912 InSync3912 1 year ago You are fantastic host! Dr. Gorbunova also looks younger compared to her previous videos:) By brown algae - does she mean laminaria? Reply Nicholas Steel Nicholas Steel 1 year ago Great conversation 👍✌️ Reply Travis atlas ♪ Travis atlas ♪ 1 year ago 🌟 Brilliant ! Thanks Siim : ) 😊👋🍀 7 Reply juulcy juulcy 1 year ago Very interesting interview and good information Reply Dan O'Hanlon Dan O'Hanlon 1 year ago Thanks— FANTASTIC! Much appreciated… 1 Reply Donny Singh Donny Singh 5 months ago Great Guest, Host & Interview ! Reply 4tun8nanette 4tun8nanette 1 year ago Thank you, Siim. Do you know a reliable source for Fucoidan? Reply 1 reply Peter Peter 1 year ago To maintain NAD+ levels without resorting to NR or NMN you might benefit from a few short talks by Michael Lustgarten PhD and Nichola Conlon PhD. Maintaining gut barrier function as we age helps keep endotoxin out of blood and therefor is less likely to promote CD38 loss of NAD+. Also, some natural food components modulate the enzymes in the NAD+ salvage pathway - quercetin, EGCG, rutin, apigenin. 4 Reply 4 replies Apple Life Apple Life 1 year ago Lots and lots of interesting information thank you Reply B B B B 2 months ago Why do we die eventually when we are fully healthy? After a long life, it seems like Vera is saying we can live to an older age if we are taking the whole list of DoNotAge products ?! or is it that we are more likely get a super bug or fall under a bus. Most people are living apparently without anything that suppresses the damages apparently natural to us, our lives will become senile. So after extending life and health what is happening, why is the battle eventually lost. I myself at 75 struggle with various inflammations arthritis but when we are visibly old we are written off by younger people who treat us differently when we look old, we are thought not to be able to contribute, we may not be able to be lively or properly useful even though as I can see many people are handicapping themselves with obesity and by seeing their life as being over after they have had children maybe they are bored long before they should and stop wishing to grow! Even now the products people like me are taking and our wish to be strong healthy and creative for as long as possible we know we can extend health how we look and our creative enthusiasm and feel valid. The hospitals are still full and doctors look askance at any suggestion that we can be more more healthy by taking NMN which has so obviously made it possible for me to renovate my letting flat being up ladders and doing most of the things my age group can’t, and even when programs come on the BBC lately they only mentioned metformin and even that with some hesitation. The Hollywood stars are the only ones believing in it “ out of desperation” for further work. Any way this is my basic feeling that belief in substances such as we take most are cynical about. I have so far not been able to convince anyone at all despite the fact that I look ten years younger than I am and that no one I know of my age will get up a high ladder and repair a ceiling and paint it, I’m female by the way. Reply Daily Dose of Medicine Daily Dose of Medicine 1 year ago 👍👍 2 Reply Rui-9-CS Rui-9-CS 1 year ago ❤️ Reply OrbitalHUB OrbitalHUB 1 year ago "Sirtuin Six''...sounds like a sci fi Special Forces Squad from Space Force 2181 ;) 4 Reply 1 reply Capricorn Sun, Sag Rising, Libra Moon Capricorn Sun, Sag Rising, Libra Moon 1 year ago Her name is NOT Dr. Vera. Her name is Dr. Gorbunova! Show respect for your guests. Reply Sanna Mati Sanna Mati 1 year ago Iam eating pile of icream and looking how can i not age soo early 1 Reply Louis Doufexis Louis Doufexis 1 year ago The food standards of Australia have issued a warning re brown algae and its high levels of iodine , which can damage thyroid etc So I won’t touch it . not fir me. ☺️ best of health everybody 1 Reply 2 replies Vel Plays! Vel Plays! 1 year ago Cute. :-) Reply The V word The V word 1 year ago 🍪 Reply Scott K Scott K 1 year ago Ugly wallpaper olympics right here Reply 3 replies